{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:10:18Z","timestamp":1791414618517,"version":"4.3.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T00:00:00Z","timestamp":1132012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s00280-005-0139-8","type":"journal-article","created":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T10:44:32Z","timestamp":1131965072000},"page":"272-275","source":"Crossref","is-referenced-by-count":37,"title":["Toxic death-case after capecitabine\u00a0+\u00a0oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency"],"prefix":"10.1007","volume":"58","author":[{"given":"Joseph","family":"Ciccolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Dales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Milano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lacarelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,11,15]]},"reference":[{"key":"139_CR1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3816\/CCC.2004.n.018","volume":"4","author":"H Ezzeldin","year":"2004","unstructured":"Ezzeldin H, Diasio R (2004) Dihydropyrimidine dehydrogenase (DPD) deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration. Clin Colorectal Cancer 4:181\u2013189","journal-title":"Clin Colorectal Cancer"},{"issue":"7","key":"139_CR2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.ejca.2003.12.004","volume":"40","author":"AB Kuilenburg Van","year":"2004","unstructured":"Van Kuilenburg AB (2004) Dihydropyrimidine dehydrogenase (DPD) and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 40(7):939\u2013950","journal-title":"Eur J Cancer"},{"issue":"8","key":"139_CR3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00001813-200409000-00005","volume":"15","author":"MW Saif","year":"2004","unstructured":"Saif MW, Wood TE, McGee PJ, Diasio RB (2004) Peripheral neuropathy associated with capecitabine. Anticancer Drugs 15(8):767\u2013771","journal-title":"Anticancer Drugs"},{"issue":"13","key":"139_CR4","first-page":"626","volume":"148","author":"EA Hooiveld","year":"2004","unstructured":"Hooiveld EA, van Kuilenburg AB, Haanen JB, Westermann AM (2004) Severe toxicity after treatment with capecitabine and fluorouracil due to partial dihydropyrimidine dehydrogenase (DPD) deficiency. Ned Tijdschr Geneeskd 148(13):626\u2013628","journal-title":"Ned Tijdschr Geneeskd"},{"key":"139_CR5","unstructured":"Fischel JL, Formento P, Ren\u00e9e N, Etienne MC, Milano G (2004) Experimental arguments for a better understanding of hand-foot syndrome under capecitabine. Presented at the American Association of Cancer Research 95th Meeting, Orlando, FL, April 2004"},{"issue":"2","key":"139_CR6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1568011043482089","volume":"4","author":"J Ciccolini","year":"2004","unstructured":"Ciccolini J, Evrard A, Cuq P (2004) Thymidine phosphorylase and fluoropyrimidines efficacy: a Jekyll and Hyde story. Curr Med Chem Anti-Canc Agents 4(2):71\u201381","journal-title":"Curr Med Chem Anti-Canc Agents"},{"key":"139_CR7","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1177\/0091270004268911","volume":"44","author":"H Jiang","year":"2004","unstructured":"Jiang H, Lu J, Jiang J, Hu P (2004) Important role of the dihydrouracil\/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics. J Clin Pharmacol 44:1260\u20131272","journal-title":"J Clin Pharmacol"},{"key":"139_CR8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2710.2004.00569.x","volume":"29","author":"J Ciccolini","year":"2004","unstructured":"Ciccolini J, Mercier C, Blachon MF, Favre R, Durand A, Lacarelle B (2004) A simple and rapid high performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity. J Clin Pharm Ther 29:309\u2013315","journal-title":"J Clin Pharm Ther"},{"key":"139_CR9","unstructured":"Ciccolini J, Etienne-Grimaldi MC, Ren\u00e9e N, Formento JL, Lacarelle B, Milano G (2005) Comparison of different approaches for predicting dihydropyrimidine deshydrogenase (DPD) deficiency in cancer patients: enzymatic activity in lymphocytes versus uracil\/dihydrouracil (U\/UH2) ratio in plasma versus IVS14+1G>A mutation screening. Presented at the American Association of Cancer Research 96th Meeting, Anaheim, CA, 16\u201320 April 2005"},{"issue":"2","key":"139_CR10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0009-9120(01)00188-6","volume":"34","author":"M Nauck","year":"2001","unstructured":"Nauck M, Gierens H, Marz W, Wieland H (2001) Rapid detection of a common dihydropyrimidine dehydrogenase (DPD) mutation associated with 5-fluorouracil (5-FU) toxicity and congenital thymine uraciluria using fluorogenic hybridisation probes. Clin Biochem 34(2):103\u2013105","journal-title":"Clin Biochem"},{"issue":"1","key":"139_CR11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/abio.2002.5666","volume":"306","author":"H Ezzeldin","year":"2002","unstructured":"Ezzeldin H, Okamoto Y, Johnson MR, Diasio RB (2002) A high-throughput denaturing high-performance liquid chromatography method for the identification of variant alleles associated with dihydropyrimidine dehydrogenase (DPD) deficiency. Anal Biochem 306(1):63\u201373","journal-title":"Anal Biochem"},{"issue":"7","key":"139_CR12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00008571-200210000-00007","volume":"12","author":"AB Kuilenburg Van","year":"2002","unstructured":"Van Kuilenburg AB, Meinsma R, Zoetekouw L, Van Gennip AH (2002) High prevalence of the IVS14+1G>A mutation in the dihydropyrimidine dehydrogenase (DPD) gene of patients with severe 5-fluorouracil (5-FU)-associated toxicity. Pharmacogenetics 12(7):555\u2013558","journal-title":"Pharmacogenetics"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-005-0139-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-005-0139-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-005-0139-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:06:16Z","timestamp":1559037976000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-005-0139-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,15]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["139"],"URL":"https:\/\/doi.org\/10.1007\/s00280-005-0139-8","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,15]]}}}