{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:45:48Z","timestamp":1767649548899},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2006,12,20]]},"DOI":"10.1007\/s00280-006-0290-x","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T19:38:38Z","timestamp":1154461118000},"page":"383-395","source":"Crossref","is-referenced-by-count":15,"title":["Reproductive toxicity evaluation of a new camptothecin anticancer agent, CKD-602, in pregnant\/lactating female rats and their offspring"],"prefix":"10.1007","volume":"59","author":[{"given":"Moon-Koo","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong-Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Choon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"290_CR1","first-page":"461","volume":"54","author":"JA Gottlieb","year":"1970","unstructured":"Gottlieb JA, Guarino AM, Call JB, Oliverio VT, Block JB (1970) Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC 100880). Cancer Chemother Rep 54:461\u2013470","journal-title":"Cancer Chemother Rep"},{"key":"290_CR2","first-page":"515","volume":"56","author":"FM Muggia","year":"1972","unstructured":"Muggia FM, Creven PJ, Hansen HH, Cohen MH, Selawry OS (1972) Phase I clinical trial of weekly and daily treatment with camptothecin (NSC 100880). Cancer Chemother Rep 56:515\u2013521","journal-title":"Cancer Chemother Rep"},{"key":"290_CR3","first-page":"95","volume":"56","author":"CG Moertel","year":"1972","unstructured":"Moertel CG, Schutt AJ, Reitmeier RJ, Hahn RG (1972) Phase II study of camptothecin (NSC 100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother Rep 56:95\u2013101","journal-title":"Cancer Chemother Rep"},{"key":"290_CR4","first-page":"1","volume":"23","author":"H Bleiberg","year":"1996","unstructured":"Bleiberg H, Rothenberg ML (1996) CPT-11: from DNA topology to clinical activity. Semin Oncol 23:1\u201350","journal-title":"Semin Oncol"},{"key":"290_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000011923","volume":"56","author":"C Kolimannsberger","year":"1999","unstructured":"Kolimannsberger C, Mross K, Jakob A, Kanz L, Bokemyer C (1999) Topotecan\u2014a novel topoisomerase I inhibitor: pharmacology and clinical experience. Oncology 56:1\u201312","journal-title":"Oncology"},{"key":"290_CR6","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1200\/JCO.1996.14.4.1236","volume":"14","author":"W Dahut","year":"1996","unstructured":"Dahut W, Harolod N, Takimototo C, Allegra C, Chen A, Hamilton JM, Arbuck S, Sorensen M, Grollman F, Nakashima H, Lieberman R, Liang M, Corse W, Grem J (1996) Phase I and pharmacokinetic study of 9-aminocamptothecin given as a 72-hour infusion in adult cancer patients. J Clin Oncol 14:1236\u20131244","journal-title":"J Clin Oncol"},{"key":"290_CR7","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1007\/s002800051077","volume":"42","author":"L Iyer","year":"1998","unstructured":"Iyer L, Ratain MJ (1998) Clinical pharmacology of camptothecins. Cancer Chemother Pharmacol 42:S31\u2013S43","journal-title":"Cancer Chemother Pharmacol"},{"key":"290_CR8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0167-4781(98)00130-4","volume":"1400","author":"CH Takimoto","year":"1998","unstructured":"Takimoto CH, Wright J, Arbuck SG (1998) Clinical applications of the camptothecins. Biochim Biophys Acta 1400:107\u2013119","journal-title":"Biochim Biophys Acta"},{"key":"290_CR9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/jps.2600810718","volume":"81","author":"J Fassberg","year":"1992","unstructured":"Fassberg J, Stella VJ (1992) A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 81:676\u2013684","journal-title":"J Pharm Sci"},{"key":"290_CR10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/jm00123a038","volume":"32","author":"RP Hertzberg","year":"1989","unstructured":"Hertzberg RP, Caranfa MJ, Holden KG, Jakas DR, Gallagher G, Mattern MR, Mong SM, Bartus JO, Johnson RK, Kingsbury WD (1989) Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32:715\u2013720","journal-title":"J Med Chem"},{"key":"290_CR11","first-page":"369","volume":"1","author":"H Hashimoto","year":"1995","unstructured":"Hashimoto H, Chatterjee S, Berger NA (1995) Mutagenic activity of topoisomerase I inhibitors. Clin Cancer Res 1:369\u2013376","journal-title":"Clin Cancer Res"},{"key":"290_CR12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1023565227808","volume":"21","author":"E Chatelut","year":"2003","unstructured":"Chatelut E, Delord JP, Canal P (2003) Toxicity patterns of cytotoxic drugs. Invest New Drugs 21:141\u2013148","journal-title":"Invest New Drugs"},{"key":"290_CR13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF02975379","volume":"21","author":"JH Lee","year":"1998","unstructured":"Lee JH, Lee JM, Kim JK, Ahn SK, Lee SJ, Kim MY, Jew SS, Park JG, Hong CI (1998) Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor. Arch Pharm Res 21:581\u2013590","journal-title":"Arch Pharm Res"},{"key":"290_CR14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0378-5173(02)00099-6","volume":"239","author":"JH Kim","year":"2002","unstructured":"Kim JH, Lee SK, Lim JL, Shin HJ, Hong CI (2002) Preformulation studies of a novel camptothecin anticancer agent, CKD-602: physicochemical characterization and hydrolytic equilibrium kinetics. Int J Pharm 239:207\u2013211","journal-title":"Int J Pharm"},{"key":"290_CR15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.2000.tb07055.x","volume":"922","author":"JH Lee","year":"2000","unstructured":"Lee JH, Lee JM, Lim KH, Kim JK, Ahn SK, Bang YJ, Hong CI (2000) Preclinical and phase I clinical studies with CKD-602, a novel camptothecin derivative. Ann NY Acad Sci 922:324\u2013325","journal-title":"Ann NY Acad Sci"},{"key":"290_CR16","first-page":"272","volume":"53","author":"EJ Kim","year":"2003","unstructured":"Kim EJ, Lee RK, Suh JE, Han SS, Kim JK (2003) Safety pharmacology of CKD-602, a novel anticancer agent. Arzneimittel Forschung 53:272\u2013279","journal-title":"Arzneimittel Forschung"},{"key":"290_CR17","first-page":"129","volume":"18","author":"KW Ha","year":"1998","unstructured":"Ha KW, Oh HY, Heo OS, Park CH, Sohn SJ, Han ES, Kim JW, Kang IH, Kang HJ, Lee SJ, Hong CL, Kim JK (1998) Genotoxicity studies of an anticancer agent of camptothecin series, CKD-602. Environ Mutagen Carcinog 18:129\u2013134","journal-title":"Environ Mutagen Carcinog"},{"key":"290_CR18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.yrtph.2004.09.002","volume":"40","author":"JC Kim","year":"2004","unstructured":"Kim JC, Shin DH, Kim SH, Kim JK, Park SC, Son WC, Lee HS, Suh JE, Kim CY, Ha CS, Chung MK (2004) Subacute toxicity evaluation of a new camptothecin anticancer agent CKD-602 administered by intravenous injection to rats. Regul Toxicol Pharmacol 40:356\u2013369","journal-title":"Regul Toxicol Pharmacol"},{"key":"290_CR19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.reprotox.2005.01.004","volume":"20","author":"MK Chung","year":"2005","unstructured":"Chung MK, Kim JC, Han SS (2005) Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in rats. Reprod Toxicol 20:165\u2013173","journal-title":"Reprod Toxicol"},{"key":"290_CR20","first-page":"35","volume":"28","author":"MK Chung","year":"2005","unstructured":"Chung MK, Kim JC, Han SS (2005) Effects of CKD-602, a new camptothecin anticancer agent, on pregnant does and embryo\u2013fetal development in rabbits. Drug Chem Toxicol 28:35\u201349","journal-title":"Drug Chem Toxicol"},{"key":"290_CR21","first-page":"125","volume":"24","author":"M Itabashi","year":"1990","unstructured":"Itabashi M, Inoue T, Fujii T (1990) Reproduction and developmental studies of CPT-11: study on administration of the test substance during the period of organogenesis in rats. Clin Rep 24:125\u2013129","journal-title":"Clin Rep"},{"key":"290_CR22","unstructured":"NRC (National Research Council) (1996) Guide for the care and use of laboratory animals. National Research Council, National Academy, Washington"},{"key":"290_CR23","first-page":"262","volume-title":"Teratology: principles and technique","author":"JG Wilson","year":"1965","unstructured":"Wilson JG (1965) Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, Warkany J (eds) Teratology: principles and technique. University of Chicago Press, Chicago and London, pp 262\u2013277"},{"key":"290_CR24","first-page":"23","volume":"14","author":"KA Nishimura","year":"1974","unstructured":"Nishimura KA (1974) Microdissection method for detecting thoracic visceral malformations in mouse and rat fetuses. Congenit Anom 14:23\u201340","journal-title":"Congenit Anom"},{"key":"290_CR25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/10520292609115636","volume":"1","author":"AB Dawson","year":"1926","unstructured":"Dawson AB (1926) A note on the staining of the skeleton of cleared specimens with Alizarin Red S. Stain Technol 1:123\u2013124","journal-title":"Stain Technol"},{"key":"290_CR26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0015-6264(70)80337-6","volume":"8","author":"CS Weil","year":"1970","unstructured":"Weil CS (1970) Selection of the valid number of sampling units and a consideration of their combination in toxicological studies involving reproduction, teratogenesis or carcinogenesis. Food Cosmet Toxicol 8:177\u2013182","journal-title":"Food Cosmet Toxicol"},{"key":"290_CR27","first-page":"87","volume":"40","author":"H Scheffe","year":"1953","unstructured":"Scheffe H (1953) A method of judging all contrasts in the analysis of variance. Biometika 40:87\u2013104","journal-title":"Biometika"},{"key":"290_CR28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/01621459.1952.10483441","volume":"47","author":"WH Kruskal","year":"1952","unstructured":"Kruskal WH, Wallis WA (1952) Use of ranks in one criterion variance analysis. J Am Stat Assoc 47:614\u2013617","journal-title":"J Am Stat Assoc"},{"key":"290_CR29","volume-title":"Statistical methods for research workers, 14th edn","author":"RA Fisher","year":"1970","unstructured":"Fisher RA (1970) Statistical methods for research workers, 14th edn. Oliver and Boyd, Edinburgh, UK"},{"key":"290_CR30","unstructured":"SAS Institute Inc. (1997) SAS\/STAT Software: changes and enhancements through release 6.12. SAS Institute, Cary"},{"key":"290_CR31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/009841001455508","volume":"17","author":"JC Kim","year":"2001","unstructured":"Kim JC, Lee SJ, Bae JS, Park JI, Kim YB, Chung MK (2001) Historical control data for developmental toxicity study in Sprague\u2013Dawley rats. J Toxicol Public Health 17:83\u201390","journal-title":"J Toxicol Public Health"},{"key":"290_CR32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1741-4520.1987.tb00703.x","volume":"27","author":"H Morita","year":"1987","unstructured":"Morita H, Ariyuki F, Inomata N, Nishimura K, Kasegawa Y, Miyamoto M (1987) Spontaneous malformation in laboratory animals: frequency of external, internal and skeletal malformations in rats, rabbits and mice. Congenit Anom 27:147\u2013206","journal-title":"Congenit Anom"},{"key":"290_CR33","unstructured":"MARTA (Middle Atlantic Reproduction Teratology Association) (1997) Appendix B: historical control data. In: Hood RD (eds) Handbook of developmental toxicology. CRC, New York, pp 716\u2013724"},{"key":"290_CR34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0300-483X(99)00056-6","volume":"136","author":"H Andersen","year":"1999","unstructured":"Andersen H, Larsen S, Spliid H, Christensen ND (1999) Multivariate statistical analysis of organ weights in toxicity studies. Toxicology 136:67\u201377","journal-title":"Toxicology"},{"key":"290_CR35","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/01926230490465874","volume":"32","author":"SA Bailey","year":"2004","unstructured":"Bailey SA, Zidell RH, Perry RW (2004) Relationships between organ weight and body\/brain weight in the rat: what is the best analytical endpoint? Toxicol Pathol 32:448\u2013466","journal-title":"Toxicol Pathol"},{"key":"290_CR36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/sj.jp.7210863","volume":"23","author":"NJ Robinson","year":"2003","unstructured":"Robinson NJ, Hodgman JE, Barton L, Pavlova Z (2003) Causes of nursery death beyond the neonatal period. J Perinatol 23:142\u2013147","journal-title":"J Perinatol"},{"key":"290_CR37","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1375\/twin.8.6.543","volume":"8","author":"PO Pharoah","year":"2005","unstructured":"Pharoah PO (2005) Causal hypothesis for some congenital anomalies. Twin Res Hum Genet 8:543\u2013550","journal-title":"Twin Res Hum Genet"},{"key":"290_CR38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2003.11.006","volume":"196","author":"JC Kim","year":"2004","unstructured":"Kim JC, Kim SH, Shin DH, Ahn TH, Kim HC, Kim YB, Jiang CZ, Han J, Chung MK (2004) Effects of prenatal exposure to the environmental pollutant 2-bromopropane on embryo\u2013fetal development in rats. Toxicology 196:77\u201386","journal-title":"Toxicology"},{"key":"290_CR39","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0140-6736(03)13780-4","volume":"361","author":"JF Pizzolato","year":"2003","unstructured":"Pizzolato JF, Saltz LB (2003) The camptothecins. Lancet 361:2235\u20132242","journal-title":"Lancet"},{"key":"290_CR40","first-page":"145","volume":"24","author":"M Itabashi","year":"1990","unstructured":"Itabashi M, Inoue T, Fujii T (1990) Reproduction and developmental studies of CPT-11: study on administration of the test substance during the perinatal and lactation periods in rats. Clin Rep 24:145\u2013149","journal-title":"Clin Rep"},{"key":"290_CR41","first-page":"90","volume":"24","author":"M Itabashi","year":"1990","unstructured":"Itabashi M, Inoue T, Amano Y, Sato K (1990) Reproduction and developmental toxicity studies of CPT-11: study on administration of the test substance prior to and in the early stages of pregnancy in rats. Clin Rep 24:90\u2013102","journal-title":"Clin Rep"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-006-0290-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-006-0290-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-006-0290-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T20:12:22Z","timestamp":1707163942000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-006-0290-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,1]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12,20]]}},"alternative-id":["290"],"URL":"https:\/\/doi.org\/10.1007\/s00280-006-0290-x","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,1]]}}}