{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:18:07Z","timestamp":1792192687995,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2007,3,19]]},"DOI":"10.1007\/s00280-006-0388-1","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T18:30:33Z","timestamp":1164738633000},"page":"847-853","source":"Crossref","is-referenced-by-count":35,"title":["Methotrexate pharmacokinetics in infants with acute lymphoblastic leukemia"],"prefix":"10.1007","volume":"59","author":[{"given":"Patrick A.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Murry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lunagomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Blaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Camitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZoAnn E.","family":"Dreyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Bomgaars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,29]]},"reference":[{"key":"388_CR1","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1016\/S0021-9258(19)84587-8","volume":"261","author":"CJ Allegra","year":"1986","unstructured":"Allegra CJ, Fine RL, Drake JC, Chabner BA (1986) The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J Biol Chem 261:6478\u20136485","journal-title":"J Biol Chem"},{"key":"388_CR2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2165\/00003088-198308030-00002","volume":"8","author":"FM Balis","year":"1983","unstructured":"Balis FM, Holcenberg JS, Bleyer WA (1983) Clinical pharmacokinetics of commonly used anticancer drugs. Clin Pharmacokinet 8:202\u2013232","journal-title":"Clin Pharmacokinet"},{"key":"388_CR3","first-page":"237","volume-title":"Principles and practice of pediatric oncology","author":"FM Balis","year":"2002","unstructured":"Balis FM, Holcenberg JS, Blaney SM (2002) General principles of chemotherapy. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. Lippincott Williams & Wilkins, Philadelphia, pp 237\u2013308"},{"key":"388_CR4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1172\/JCI112872","volume":"79","author":"J Baram","year":"1987","unstructured":"Baram J, Allegra CJ, Fine RL, Chabner BA (1987) Effect of methotrexate on intracellular folate pools in purified myeloid precursor cells from normal human bone marrow. J Clin Invest 79:692\u2013697","journal-title":"J Clin Invest"},{"key":"388_CR5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-4347(94)00328-9","volume":"661","author":"S Belz","year":"1994","unstructured":"Belz S, Frickel C, Wolfrom C, Nau H, Henze G (1994) High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid. J Chromatogr B Biomed Appl 661:109\u2013118","journal-title":"J Chromatogr B Biomed Appl"},{"key":"388_CR6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1097-0142(197801)41:1<36::AID-CNCR2820410108>3.0.CO;2-I","volume":"41","author":"WA Bleyer","year":"1978","unstructured":"Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41:36\u201351","journal-title":"Cancer"},{"key":"388_CR7","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.1989.7.10.1539","volume":"7","author":"B Camitta","year":"1989","unstructured":"Camitta B, Leventhal B, Lauer S, Shuster JJ, Adair S, Casper J, Civin C, Graham M, Mahoney D, Munoz L (1989) Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study. J Clin Oncol 7:1539\u20131544","journal-title":"J Clin Oncol"},{"key":"388_CR8","first-page":"109","volume-title":"Cancer chemotherapy and biotherapy: principles and practice","author":"E Chu","year":"1996","unstructured":"Chu E, Allegra CJ (1996) Antifolates. In: Chabner BA, Longo DL (eds) Cancer chemotherapy and biotherapy: principles and practice. Lippincott-Raven, Philadelphia, pp 109\u2013148"},{"key":"388_CR9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/mpo.2950240303","volume":"24","author":"MG Donelli","year":"1995","unstructured":"Donelli MG, Zucchetti M, Robatto A, Perlangeli V, D\u2019Incalci M, Masera G, Rossi MR (1995) Pharmacokinetics of HD-MTX in infants, children, and adolescents with non-B acute lymphoblastic leukemia. Med Pediatr Oncol 24:154\u2013159","journal-title":"Med Pediatr Oncol"},{"key":"388_CR10","unstructured":"Dreyer ZE (2004) Personal observation by POG 9407 study chair regarding toxicity in infants treated for ALL"},{"key":"388_CR11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jchromb.2004.11.037","volume":"817","author":"K Fotoohi","year":"2005","unstructured":"Fotoohi K, Skarby T, Soderhall S, Peterson C, Albertioni F (2005) Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays. J Chromatogr B Analyt Technol Biomed Life Sci 817:139\u2013144","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"Suppl 2","key":"388_CR12","first-page":"264+","volume":"47","author":"B Friis-Hansen","year":"1971","unstructured":"Friis-Hansen B (1971) Body composition during growth. In vivo measurements and biochemical data correlated to differential anatomical growth. Pediatrics 47(Suppl 2):264+","journal-title":"In vivo measurements and biochemical data correlated to differential anatomical growth. Pediatrics"},{"key":"388_CR13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0163-7258(85)90083-X","volume":"28","author":"ID Goldman","year":"1985","unstructured":"Goldman ID, Matherly LH (1985) The cellular pharmacology of methotrexate. Pharmacol Ther 28:77\u2013102","journal-title":"Pharmacol Ther"},{"key":"388_CR14","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/cpt1973144part1572","volume":"14","author":"DH Huffman","year":"1973","unstructured":"Huffman DH, Wan SH, Azarnoff DL, Hogstraten B (1973) Pharmacokinetics of methotrexate. Clin Pharmacol Ther 14:572\u2013579","journal-title":"Clin Pharmacol Ther"},{"key":"388_CR15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/cpt1969106849","volume":"10","author":"DG Liegler","year":"1969","unstructured":"Liegler DG, Henderson ES, Hahn MA, Oliverio VT (1969) The effect of organic acids on renal clearance of methotrexate in man. Clin Pharmacol Ther 10:849\u2013857","journal-title":"Clin Pharmacol Ther"},{"key":"388_CR16","first-page":"S23","volume":"18","author":"HL McLeod","year":"1992","unstructured":"McLeod HL, Relling MV, Crom WR, Silverstein K, Groom S, Rodman JH, Rivera GK, Crist WM, Evans WE (1992) Disposition of antineoplastic agents in the very young child. Br J Cancer Suppl 18:S23\u2013S29","journal-title":"Br J Cancer Suppl"},{"issue":"Suppl 11","key":"388_CR17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1289\/ehp.94102s11107","volume":"102","author":"RL Milsap","year":"1994","unstructured":"Milsap RL, Jusko WJ (1994) Pharmacokinetics in the infant. Environ Health Perspect 102(Suppl 11):107\u2013110","journal-title":"Environ Health Perspect"},{"key":"388_CR18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/j.1875-9114.1995.tb04347.x","volume":"15","author":"DJ Murry","year":"1995","unstructured":"Murry DJ, Synold TW, Pui CH, Rodman JH (1995) Renal function and methotrexate clearance in children with newly diagnosed leukemia. Pharmacotherapy 15:144\u2013149","journal-title":"Pharmacotherapy"},{"key":"388_CR19","first-page":"287","volume":"3","author":"SE Siegel","year":"1981","unstructured":"Siegel SE, Moran RG (1981) Problems in the chemotherapy of cancer in the neonate. Am J Pediatr Hematol Oncol 3:287\u2013296","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"388_CR20","first-page":"548","volume":"6","author":"CF Stewart","year":"1987","unstructured":"Stewart CF, Hampton EM (1987) Effect of maturation on drug disposition in pediatric patients. Clin Pharm 6:548\u2013564","journal-title":"Clin Pharm"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-006-0388-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-006-0388-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-006-0388-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T15:27:34Z","timestamp":1707406054000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-006-0388-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,29]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,3,19]]}},"alternative-id":["388"],"URL":"https:\/\/doi.org\/10.1007\/s00280-006-0388-1","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,29]]}}}