{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:51:33Z","timestamp":1791021093317,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T00:00:00Z","timestamp":1183507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1007\/s00280-007-0517-5","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T10:19:32Z","timestamp":1183457972000},"page":"639-645","source":"Crossref","is-referenced-by-count":71,"title":["The role of calcium, P38 MAPK in dihydroartemisinin-induced apoptosis of lung cancer PC-14 cells"],"prefix":"10.1007","volume":"61","author":[{"given":"Deguang","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongling","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,7,4]]},"reference":[{"issue":"3","key":"517_CR1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","volume":"88","author":"MD Jacobson","year":"1997","unstructured":"Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88(3):347\u2013354","journal-title":"Cell"},{"issue":"3","key":"517_CR2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1006\/bbrc.1999.1888","volume":"266","author":"B Fadeel","year":"1999","unstructured":"Fadeel B, Orrenius S, Zhivotovsky B (1999) Apoptosis in human disease: a new skin for the old ceremony? Biochem Biophys Res Commun 266(3):699\u2013717","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"517_CR3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/carcin\/bgh283","volume":"26","author":"R Gerl","year":"2005","unstructured":"Gerl R, Vaux DL (2005) Apoptosis in the development and treatment of cancer. Carcinogenesis 26(2):263\u2013270","journal-title":"Carcinogenesis"},{"issue":"2","key":"517_CR4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.toxlet.2003.12.009","volume":"147","author":"T Gordi","year":"2004","unstructured":"Gordi T, Lepist EI (2004) Artemisinin derivatives: toxic for laboratory animals, safe for humans? Toxicol Lett 147(2):99\u2013107","journal-title":"Toxicol Lett"},{"issue":"4","key":"517_CR5","first-page":"2277","volume":"24","author":"NP Singh","year":"2004","unstructured":"Singh NP, Lai HC (2004) Artemisinin induces apoptosis in human cancer cells. Anticancer Res 24(4):2277\u20132280","journal-title":"Anticancer Res"},{"issue":"4","key":"517_CR6","first-page":"767","volume":"18","author":"T Efferth","year":"2001","unstructured":"Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR (2001) The anti-malarial artesunate is also active against cancer. Int J Oncol 18(4):767\u2013773","journal-title":"Int J Oncol"},{"issue":"6","key":"517_CR7","first-page":"1599","volume":"14","author":"TG Berger","year":"2005","unstructured":"Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO, Baur A, Schuler G (2005) Artesunate in the treatment of metastatic uveal melanoma\u2013first experiences. Oncol Rep 14(6):1599\u20131603","journal-title":"Oncol Rep"},{"issue":"1\u20132","key":"517_CR8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0005-2728(98)00110-8","volume":"1366","author":"SA Susin","year":"1998","unstructured":"Susin SA, Zamzami N, Kroemer G (1998) Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1366(1\u20132):151\u2013165","journal-title":"Biochim Biophys Acta"},{"issue":"2\u20133","key":"517_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0143-4160(98)90116-6","volume":"23","author":"P Nicotera","year":"1998","unstructured":"Nicotera P, Orrenius S (1998) The role of calcium in apoptosis. Cell Calcium 23(2\u20133):173\u2013180","journal-title":"Cell Calcium"},{"issue":"4","key":"517_CR10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.bbrc.2006.09.103","volume":"350","author":"YQ Zhou","year":"2006","unstructured":"Zhou YQ, Wang B, Mark E, Chung DH (2006) Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK. Biochem Biophys Res Commun 350(4):860\u2013865","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"517_CR11","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.lfs.2006.04.011","volume":"79","author":"SK Lee","year":"2006","unstructured":"Lee SK, Jang HJ, Lee HJ, Lee J, Jeon BH, Jun CD, Lee SK, Kim EC (2006) p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes. Life Sci 79(15):1419\u20131427","journal-title":"Life Sci"},{"issue":"1\u20132","key":"517_CR12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1\u20132):55\u201363","journal-title":"J Immunol Methods"},{"issue":"43","key":"517_CR13","doi-asserted-by":"crossref","first-page":"33585","DOI":"10.1074\/jbc.M003890200","volume":"275","author":"S Kotamraju","year":"2000","unstructured":"Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B (2000) Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem 275(43):33585\u201333592","journal-title":"J Biol Chem"},{"issue":"4","key":"517_CR14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0006-2952(02)01221-2","volume":"64","author":"T Efferth","year":"2002","unstructured":"Efferth T, Olbrich A, Bauer R (2002) mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochem Pharmacol 64(4):617\u2013623","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"517_CR15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.canlet.2004.03.014","volume":"211","author":"C Huan-huan","year":"2004","unstructured":"Huan-huan C, Li-Li Y, Shang-Bin L (2004) Artesunate reduces chicken chorioallantoic membrane neovascularisation and exhibits antiangiogenic and apoptotic activity on human microvascular dermal endothelial cell. Cancer Lett 211(2):163\u2013173","journal-title":"Cancer Lett"},{"issue":"7","key":"517_CR16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.freeradbiomed.2004.06.023","volume":"37","author":"T Efferth","year":"2004","unstructured":"Efferth T, Benakis A, Romero MR, Tomicic M, Rauh R, Steinbach D, Hafer R, Stamminger T, Oesch F, Kaina B, Marschall M (2004) Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 37(7):998\u20131009","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"517_CR17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.vph.2004.11.001","volume":"41","author":"GD Wu","year":"2004","unstructured":"Wu GD, Zhou HJ, Wu XH (2004) Apoptosis of human umbilical vein endothelial cells induced by artesunate. Vascul Pharmacol 41(6):205\u2013212","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"517_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/s-2006-959408","volume":"60","author":"GQ Zheng","year":"1994","unstructured":"Zheng GQ (1994) Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med 60(1):54\u201357","journal-title":"Planta Med"},{"issue":"4","key":"517_CR19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1021\/np9605495","volume":"60","author":"AC Beekman","year":"1997","unstructured":"Beekman AC, Barentsen AR, Woerdenbag HJ, Van Uden W, Pras N, Konings AW, el-Feraly FS, Galal AM, Wikstrom HV (1997) Stereochemistry-dependent cytotoxicity of some artemisinin derivatives. J Nat Prod 60(4):325\u2013330","journal-title":"J Nat Prod"},{"issue":"12","key":"517_CR20","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.2042-7158.1997.tb06080.x","volume":"49","author":"AC Beekman","year":"1997","unstructured":"Beekman AC, Woerdenbag HJ, Van Uden W, Pras N, Konings AW, Wikstrom HV (1997) Stability of artemisinin in aqueous environments: impact on its cytotoxic action to Ehrlich ascites tumour cells. J Pharm Pharmacol 49(12):1254\u20131258","journal-title":"J Pharm Pharmacol"},{"issue":"11","key":"517_CR21","doi-asserted-by":"crossref","first-page":"E263","DOI":"10.1038\/ncb1102-e263","volume":"4","author":"K Venkatachalam","year":"2002","unstructured":"Venkatachalam K, van Rossum DB, Patterson RL, Ma HT, Gill DL (2002) The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol 4(11):E263\u2013E272","journal-title":"Nat Cell Biol"},{"issue":"2","key":"517_CR22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/bbrc.1997.7409","volume":"239","author":"DJ McConkey","year":"1997","unstructured":"McConkey DJ, Orrenius S (1997) The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun 239(2):357\u2013366","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"517_CR23","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bbrc.2006.06.159","volume":"347","author":"S Grethe","year":"2006","unstructured":"Grethe S, Coltella N, Di Renzo MF, Porn-Ares MI (2006) p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis. Biochem Biophys Res Commun 347(3):781\u2013790","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"517_CR24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.yjmcc.2006.01.021","volume":"40","author":"DJ Jiang","year":"2006","unstructured":"Jiang DJ, Jia SJ, Dai Z, Li YJ (2006) Asymmetric dimethylarginine induces apoptosis via p38 MAPK\/caspase-3-dependent signaling pathway in endothelial cells. J Mol Cell Cardiol 40(4):529\u2013539","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"517_CR25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cyto.2005.07.014","volume":"32","author":"C Petersen","year":"2005","unstructured":"Petersen C, Svechnikov K, Froysa B, Soder O (2005) The p38 MAPK pathway mediates interleukin-1-induced Sertoli cell proliferation. Cytokine 32(1):51\u201359","journal-title":"Cytokine"},{"issue":"2","key":"517_CR26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.atherosclerosis.2004.05.019","volume":"176","author":"T Senokuchi","year":"2004","unstructured":"Senokuchi T, Matsumura T, Sakai M, Matsuo T, Yano M, Kiritoshi S, Sonoda K, Kukidome D, Nishikawa T, Araki E (2004) Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein. Atherosclerosis 176(2):233\u2013245","journal-title":"Atherosclerosis"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-007-0517-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-007-0517-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-007-0517-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:06:46Z","timestamp":1559038006000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-007-0517-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1007\/s00280-007-0517-5","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,4]]}}}