{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:39:56Z","timestamp":1789907996363,"version":"4.0.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T00:00:00Z","timestamp":1454716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00280-016-2963-4","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T08:34:00Z","timestamp":1454747640000},"page":"629-634","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["UCA1 overexpression predicts clinical outcome of patients with ovarian cancer receiving adjuvant chemotherapy"],"prefix":"10.1007","volume":"77","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xili","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,6]]},"reference":[{"key":"2963_CR1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10555-014-9540-2","volume":"34","author":"KL Knutson","year":"2015","unstructured":"Knutson KL, Karyampudi L, Lamichhane P, Preston C (2015) Targeted immune therapy of ovarian cancer. Cancer Metastasis Rev 34:53\u201374","journal-title":"Cancer Metastasis Rev"},{"key":"2963_CR2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87\u2013108","journal-title":"CA Cancer J Clin"},{"key":"2963_CR3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.tig.2008.04.005","volume":"24","author":"G Elgar","year":"2008","unstructured":"Elgar G, Vavouri T (2008) Tuning into the signals: noncoding sequence conservation in vertebrate genomes. Trends Genet 24:344\u2013352","journal-title":"Trends Genet"},{"key":"2963_CR4","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jso.23888","volume":"111","author":"X Zhang","year":"2015","unstructured":"Zhang X, Xu Y, He C, Guo X, Zhang J, He C, Zhang L, Kong M, Chen B, Zhu C (2015) Elevated expression of CCAT2 is associated with poor prognosis in esophageal squamous cell carcinoma. J Surg Oncol 111:834\u2013839","journal-title":"J Surg Oncol"},{"key":"2963_CR5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","volume":"447","author":"ENCODE Project Consortium","year":"2007","unstructured":"ENCODE Project Consortium (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799\u2013816","journal-title":"Nature"},{"key":"2963_CR6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"KC Wang","year":"2011","unstructured":"Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904\u2013914","journal-title":"Mol Cell"},{"key":"2963_CR7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13277-014-2894-9","volume":"36","author":"L Gan","year":"2015","unstructured":"Gan L, Xu M, Zhang Y, Zhang X, Guo W (2015) Focusing on long noncoding RNA dysregulation in gastric cancer. Tumour Biol 36:129\u2013141","journal-title":"Tumour Biol"},{"key":"2963_CR8","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.febslet.2014.03.038","volume":"588","author":"G Guo","year":"2014","unstructured":"Guo G, Kang Q, Chen Q, Chen Z, Wang J, Tan L, Chen JL (2014) High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Lett 588:1780\u20131786","journal-title":"FEBS Lett"},{"key":"2963_CR9","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1042\/BST20120020","volume":"40","author":"LW Harries","year":"2012","unstructured":"Harries LW (2012) Long non-coding RNAs and human disease. Biochem Soc Trans 40:902\u2013906","journal-title":"Biochem Soc Trans"},{"key":"2963_CR10","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.2174\/138945012803530026","volume":"13","author":"M Kitagawa","year":"2012","unstructured":"Kitagawa M, Kotake Y, Ohhata T (2012) Long non-coding RNAs involved in cancer development and cell fate determination. Curr Drug Targets 13:1616\u20131621","journal-title":"Curr Drug Targets"},{"key":"2963_CR11","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1073\/pnas.1507882112","volume":"112","author":"A Salameh","year":"2015","unstructured":"Salameh A, Lee AK, Cardo-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchio S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W (2015) PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proc Natl Acad Sci USA 112:8403\u20138408","journal-title":"Proc Natl Acad Sci USA"},{"key":"2963_CR12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s12094-015-1290-2","volume":"17","author":"Q Zheng","year":"2015","unstructured":"Zheng Q, Wu F, Dai WY, Zheng DC, Zheng C, Ye H, Zhou B, Chen JJ, Chen P (2015) Aberrant expression of UCA1 in gastric cancer and its clinical significance. Clin Transl Oncol 17:640\u2013646","journal-title":"Clin Transl Oncol"},{"key":"2963_CR13","first-page":"23","volume":"2","author":"M Morlando","year":"2015","unstructured":"Morlando M, Ballarino M, Fatica A (2015) Long non-coding RNAs: new players in hematopoiesis and leukemia. Front Med (Lausanne) 2:23","journal-title":"Front Med (Lausanne)"},{"key":"2963_CR14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2012.01.012","volume":"496","author":"C Yang","year":"2012","unstructured":"Yang C, Li X, Wang Y, Zhao L, Chen W (2012) Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene 496:8\u201316","journal-title":"Gene"},{"key":"2963_CR15","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.18632\/oncotarget.3219","volume":"6","author":"F Wang","year":"2015","unstructured":"Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL, Chen J, Liu X, Wang SK (2015) Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1\/ERK signaling pathway. Oncotarget 6:7899\u20137917","journal-title":"Oncotarget"},{"key":"2963_CR16","first-page":"11824","volume":"8","author":"HM Wang","year":"2015","unstructured":"Wang HM, Lu JH, Chen WY, Gu AQ (2015) Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma. Int J Clin Exp Med 8:11824\u201311830","journal-title":"Int J Clin Exp Med"},{"key":"2963_CR17","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.febslet.2008.05.012","volume":"582","author":"F Wang","year":"2008","unstructured":"Wang F, Li X, Xie X, Zhao L, Chen W (2008) UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett 582:1919\u20131927","journal-title":"FEBS Lett"},{"key":"2963_CR18","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1261\/rna.359007","volume":"13","author":"WP Tsang","year":"2007","unstructured":"Tsang WP, Wong TW, Cheung AH, Co CN, Kwok TT (2007) Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA 13:890\u2013898","journal-title":"RNA"},{"key":"2963_CR19","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1007\/s13277-014-1925-x","volume":"35","author":"M Xue","year":"2014","unstructured":"Xue M, Li X, Li Z, Chen W (2014) Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion. Tumour Biol 35:6901\u20136912","journal-title":"Tumour Biol"},{"key":"2963_CR20","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/PAT.0000000000000125","volume":"46","author":"Y Han","year":"2014","unstructured":"Han Y, Yang YN, Yuan HH, Zhang TT, Sui H, Wei XL, Liu L, Huang P, Zhang WJ, Bai YX (2014) UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology 46:396\u2013401","journal-title":"Pathology"},{"key":"2963_CR21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4149\/neo_2015_051","volume":"62","author":"F Wang","year":"2015","unstructured":"Wang F, Zhou J, Xie X, Hu J, Chen L, Hu Q, Guo H, Yu C (2015) Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells. Neoplasma 62:432\u2013438","journal-title":"Neoplasma"},{"key":"2963_CR22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","volume":"92","author":"P Therasse","year":"2000","unstructured":"Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, Gwyther SG (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205\u2013216","journal-title":"J Natl Cancer Inst"},{"key":"2963_CR23","doi-asserted-by":"crossref","first-page":"e1583","DOI":"10.1038\/cddis.2014.541","volume":"6","author":"MZ Ma","year":"2015","unstructured":"Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015) Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis 6:e1583","journal-title":"Cell Death Dis"},{"key":"2963_CR24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.oooo.2013.09.007","volume":"117","author":"Z Fang","year":"2014","unstructured":"Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H (2014) Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol 117:89\u201395","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2963_CR25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/CMR.0000000000000080","volume":"24","author":"Y Tian","year":"2014","unstructured":"Tian Y, Zhang X, Hao Y, Fang Z, He Y (2014) Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res 24:335\u2013341","journal-title":"Melanoma Res"},{"key":"2963_CR26","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1007\/s13277-014-2321-2","volume":"35","author":"T Wang","year":"2014","unstructured":"Wang T, Yuan J, Feng N, Li Y, Lin Z, Jiang Z, Gui Y (2014) Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer. Tumour Biol 35:10075\u201310084","journal-title":"Tumour Biol"},{"key":"2963_CR27","first-page":"138","volume":"10","author":"SP Liu","year":"2013","unstructured":"Liu SP, Yang JX, Cao DY, Shen K (2013) Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med 10:138\u2013141","journal-title":"Cancer Biol Med"},{"key":"2963_CR28","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3892\/or.2014.3092","volume":"31","author":"M Xue","year":"2014","unstructured":"Xue M, Li X, Wu W, Zhang S, Wu S, Li Z, Chen W (2014) Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT\/enhancer binding protein alpha contributes to bladder cancer cell growth and reduced apoptosis. Oncol Rep 31:1993\u20132000","journal-title":"Oncol Rep"},{"key":"2963_CR29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3892\/or.2014.3309","volume":"32","author":"X Wang","year":"2014","unstructured":"Wang X, Gong Y, Jin B, Wu C, Yang J, Wang L, Zhang Z, Mao Z (2014) Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells. Oncol Rep 32:1281\u20131290","journal-title":"Oncol Rep"},{"key":"2963_CR30","first-page":"934","volume":"4","author":"Y Xu","year":"2014","unstructured":"Xu Y, Pan Q, Wang C, He C, Su Z, Guo X, Zhang J, Kong M, Ke S, Zhang J, Chen B, Sheng H, Zhang X (2014) Genetic polymorphisms in oxidative stress-related genes are associated with clinical outcome in patients with advanced non-small cell lung cancer receiving tyrosine kinase inhibitors. Am J Cancer Res 4:934\u2013942","journal-title":"Am J Cancer Res"},{"key":"2963_CR31","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/jjco\/hyv132","volume":"45","author":"HJ Li","year":"2015","unstructured":"Li HJ, Li X, Pang H, Pan JJ, Xie XJ, Chen W (2015) Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. Jpn J Clin Oncol 45:1055\u20131063","journal-title":"Jpn J Clin Oncol"},{"key":"2963_CR32","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/febs.12737","volume":"281","author":"Y Fan","year":"2014","unstructured":"Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F, Liu Y (2014) Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J 281:1750\u20131758","journal-title":"FEBS J"},{"key":"2963_CR33","doi-asserted-by":"crossref","first-page":"23582","DOI":"10.18632\/oncotarget.4361","volume":"6","author":"N Cheng","year":"2015","unstructured":"Cheng N, Cai W, Ren S, Li X, Wang Q, Pan H, Zhao M, Li J, Zhang Y, Zhao C, Chen X, Fei K, Zhou C, Hirsch FR (2015) Long non-coding RNA UCA1 induces non-T790\u00a0M acquired resistance to EGFR-TKIs by activating the AKT\/mTOR pathway in EGFR-mutant non-small cell lung cancer. Oncotarget 6:23582\u201323593","journal-title":"Oncotarget"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-016-2963-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-016-2963-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-016-2963-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T09:56:22Z","timestamp":1567590982000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-016-2963-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,6]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["2963"],"URL":"https:\/\/doi.org\/10.1007\/s00280-016-2963-4","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,6]]}}}