{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:18:06Z","timestamp":1790720286434,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T00:00:00Z","timestamp":1460160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00280-016-2986-x","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T08:58:22Z","timestamp":1460192302000},"page":"1079-1086","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A phase I dose escalation study of NK012, an SN-38 incorporating macromolecular polymeric micelle"],"prefix":"10.1007","volume":"77","author":[{"given":"Howard A.","family":"Burris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Anthony Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana S.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C.","family":"Bendell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nambu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne F.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,9]]},"reference":[{"key":"2986_CR1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s11095-010-0233-4","volume":"27","author":"C Oerlemans","year":"2010","unstructured":"Oerlemans C, Bult W, Bos M et al (2010) Polymeric micelles in anticancer therapy: targeting, imaging, and triggered release. Pharm Res 27:2569\u20132589","journal-title":"Pharm Res"},{"key":"2986_CR2","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1158\/0008-5472.CAN-06-1605","volume":"66","author":"F Koizumi","year":"2006","unstructured":"Koizumi F, Kitagawa M, Negishi T et al (2006) Novel SN-38-incorporating micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. Cancer Res 66:10048\u201310056","journal-title":"Cancer Res"},{"key":"2986_CR3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.addr.2010.05.008","volume":"63","author":"Y Matsumura","year":"2011","unstructured":"Matsumura Y (2011) Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect. Adv Drug Deliv Rev 63:184\u2013192","journal-title":"Adv Drug Deliv Rev"},{"key":"2986_CR4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/jjco\/hyn116","volume":"38","author":"Y Matsumura","year":"2008","unstructured":"Matsumura Y (2008) Polymeric micellar delivery systems in oncology. Jpn J Clin Oncol 38:793\u2013802","journal-title":"Jpn J Clin Oncol"},{"key":"2986_CR5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1349-7006.2008.00806.x","volume":"99","author":"Y Saito","year":"2008","unstructured":"Saito Y, Yasunaga M, Kuroda J et al (2008) Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor. Cancer Sci 99:1258\u20131264","journal-title":"Cancer Sci"},{"key":"2986_CR6","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1158\/0008-5472.CAN-07-6532","volume":"68","author":"M Sumitomo","year":"2008","unstructured":"Sumitomo M, Koizumi F, Asano T et al (2008) Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression. Cancer Res 68:1631\u20131635","journal-title":"Cancer Res"},{"key":"2986_CR7","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1002\/ijc.24171","volume":"124","author":"J Kuroda","year":"2009","unstructured":"Kuroda J, Kuratsu J, Yasunaga M et al (2009) Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma. Int J Cancer 124:2505\u20132511","journal-title":"Int J Cancer"},{"key":"2986_CR8","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1158\/0008-5472.CAN-08-2822","volume":"68","author":"TE Nakajima","year":"2008","unstructured":"Nakajima TE, Yanagihara K, Takigahira M et al (2008) Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan. Cancer Res 68:9318\u20139322","journal-title":"Cancer Res"},{"key":"2986_CR9","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1158\/1078-0432.CCR-10-1467","volume":"16","author":"A Takahashi","year":"2010","unstructured":"Takahashi A, Ohkohchi N, Yasunaga M et al (2010) Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases. Clin Cancer Res 16:4822\u20134831","journal-title":"Clin Cancer Res"},{"key":"2986_CR10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ejca.2009.11.014","volume":"46","author":"Y Saito","year":"2010","unstructured":"Saito Y, Yasunaga M, Kuroda J et al (2010) Antitumor activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour. Eur J Cancer 46:650\u2013658","journal-title":"Eur J Cancer"},{"key":"2986_CR11","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1158\/1078-0432.CCR-10-0387","volume":"16","author":"T Hamaguchi","year":"2010","unstructured":"Hamaguchi T, Doi T, Eguchi-Nakajima T et al (2010) Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors. Clin Cancer Res 16:5058\u20135066","journal-title":"Clin Cancer Res"},{"key":"2986_CR12","first-page":"115","volume":"17","author":"T Taguchi","year":"1990","unstructured":"Taguchi T, Wakui A, Hasegawa K et al (1990) Phase I clinical study of CPT-11. Research group of CPT-11. Gan To Kagaku Ryoho 17:115\u2013120","journal-title":"Gan To Kagaku Ryoho"},{"key":"2986_CR13","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1200\/JCO.2004.10.047","volume":"22","author":"EA Perez","year":"2004","unstructured":"Perez EA, Hillman DW, Mailliard JA et al (2004) Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both. J Clin Oncol 22:2849\u20132855","journal-title":"J Clin Oncol"},{"key":"2986_CR14","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/ijc.23381","volume":"122","author":"TE Nakajima","year":"2008","unstructured":"Nakajima TE, Yasunaga M, Kano Y et al (2008) Synergistic antitumor activity of the novel SN-38 incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. Int J Cancer 122:2148\u20132153","journal-title":"Int J Cancer"},{"key":"2986_CR15","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1158\/1078-0432.CCR-08-3334","volume":"15","author":"T Nagano","year":"2009","unstructured":"Nagano T, Yasunaga M, Goto K et al (2009) Antitumor activity of NK012 combined with cisplatin against small cell lung cancer and intestinal mucosal changes in tumor-bearing mouse after treatment. Clin Cancer Res 15:4348\u20134355","journal-title":"Clin Cancer Res"},{"key":"2986_CR16","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1002\/cncr.25233","volume":"116","author":"H Kenmotsu","year":"2010","unstructured":"Kenmotsu H, Yasunaga M, Goto K et al (2010) The antitumor activity of NK-012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts. Cancer 116:4597\u20134604","journal-title":"Cancer"},{"key":"2986_CR17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1158\/1078-0432.CCR-09-2393","volume":"16","author":"JI Kuroda","year":"2010","unstructured":"Kuroda JI, Kuratsu JI, Yasunaga M et al (2010) Antitumor effect of NK012, a 7-ethyl-10-hydroxycamptothecin-incorporating polymeric micelle, on U87MG orthotopic glioblastoma in mice compared with irinotecan hydrochloride in combination with bevacizumab. Clin Cancer Res 16:521\u2013529","journal-title":"Clin Cancer Res"},{"key":"2986_CR18","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1002\/ijc.25282","volume":"127","author":"T Nagano","year":"2010","unstructured":"Nagano T, Yasunaga M, Goto K et al (2010) Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer. Int J Cancer 127:2699\u20132706","journal-title":"Int J Cancer"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-016-2986-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-016-2986-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-016-2986-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:07:40Z","timestamp":1559038060000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-016-2986-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,9]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["2986"],"URL":"https:\/\/doi.org\/10.1007\/s00280-016-2986-x","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,9]]}}}