{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:36:47Z","timestamp":1783111007657,"version":"3.54.6"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00280-018-3727-0","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T03:44:43Z","timestamp":1542253483000},"page":"277-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Knockdown of long non-coding HOTAIR enhances the sensitivity to progesterone in endometrial cancer by epigenetic regulation of progesterone receptor isoform B"],"prefix":"10.1007","volume":"83","author":[{"given":"Shuqi","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"issue":"6","key":"3727_CR1","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","volume":"49","author":"J Ferlay","year":"2013","unstructured":"Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F (2013) Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 49(6):1374\u20131403","journal-title":"Eur J Cancer"},{"issue":"4","key":"3727_CR2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.maturitas.2008.12.018","volume":"62","author":"AE Schindler","year":"2009","unstructured":"Schindler AE (2009) Progestogen deficiency and endometrial cancer risk. Maturitas 62(4):334\u2013337","journal-title":"Maturitas"},{"issue":"1","key":"3727_CR3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1210\/er.2012-1043","volume":"34","author":"JJ Kim","year":"2013","unstructured":"Kim JJ, Kurita T, Bulun SE (2013) Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev 34(1):130\u2013162","journal-title":"Endocr Rev"},{"issue":"7","key":"3727_CR4","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/IGC.0b013e3181e94f5a","volume":"20","author":"S Erkanli","year":"2010","unstructured":"Erkanli S, Ayhan A (2010) Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer 20(7):1170\u20131187","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"3727_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1055\/s-0029-1242998","volume":"28","author":"JJ Kim","year":"2010","unstructured":"Kim JJ, Chapman-Davis E (2010) Role of progesterone in endometrial cancer. Semin Reprod Med 28(1):81\u201390","journal-title":"Semin Reprod Med"},{"issue":"6","key":"3727_CR6","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/IGC.0b013e3181aae1fb","volume":"19","author":"HS Hahn","year":"2009","unstructured":"Hahn HS, Yoon SG, Hong JS, Hong SR, Park SJ, Lim JY, Kwon YS, Lee IH, Lim KT, Lee KH, Shim JU, Mok JE, Kim TJ (2009) Conservative treatment with progestin and pregnancy outcomes in endometrial cancer. Int J Gynecol Cancer 19(6):1068\u20131073","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"3727_CR7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/S0090-8258(02)00008-2","volume":"88","author":"S Wang","year":"2003","unstructured":"Wang S, Pudney J, Song J, Mor G, Schwartz PE, Zheng W (2003) Mechanisms involved in the evolution of progestin resistance in human endometrial hyperplasia\u2014precursor of endometrial cancer. Gynecol Oncol 88(2):108\u2013117","journal-title":"Gynecol Oncol"},{"issue":"5","key":"3727_CR8","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","volume":"9","author":"P Kastner","year":"1990","unstructured":"Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO j 9(5):1603\u20131614","journal-title":"EMBO j"},{"issue":"3","key":"3727_CR9","first-page":"881","volume":"62","author":"D Dai","year":"2002","unstructured":"Dai D, Wolf DM, Litman ES, White MJ, Leslie KK (2002) Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors. Cancer Res 62(3):881\u2013886","journal-title":"Cancer Res"},{"issue":"2","key":"3727_CR10","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ygyno.2004.01.042","volume":"93","author":"H Sakaguchi","year":"2004","unstructured":"Sakaguchi H, Fujimoto J, Hong BL, Nakagawa Y, Tamaya T (2004) Drastic decrease of progesterone receptor form B but not A mRNA reflects poor patient prognosis in endometrial cancers. Gynecol Oncol 93(2):394\u2013399","journal-title":"Gynecol Oncol"},{"issue":"5","key":"3727_CR11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/path.1738","volume":"205","author":"JM Pijnenborg","year":"2005","unstructured":"Pijnenborg JM, Romano A, Dam-de Veen GC, Dunselman GA, Fischer DC, Groothuis PG, Kieback DG (2005) Aberrations in the progesterone receptor gene and the risk of recurrent endometrial carcinoma. J Pathol 205(5):597\u2013605","journal-title":"J Pathol"},{"issue":"3","key":"3727_CR12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12672-011-0065-7","volume":"2","author":"NL Neubauer","year":"2011","unstructured":"Neubauer NL, Ward EC, Patel P, Lu Z, Lee I, Blok LJ, Hanifi-Moghaddam P, Schink J, Kim JJ (2011) Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis. Horm Cancer 2(3):170\u2013181","journal-title":"Horm Cancer"},{"issue":"4","key":"3727_CR13","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1210\/en.2007-0756","volume":"149","author":"EC Ward","year":"2008","unstructured":"Ward EC, Hoekstra AV, Blok LJ, Hanifi-Moghaddam P, Lurain JR, Singh DK, Buttin BM, Schink JC, Kim JJ (2008) The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinoma. Endocrinology 149(4):1942\u20131950","journal-title":"Endocrinology"},{"issue":"6","key":"3727_CR14","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1046\/j.1365-2265.2003.01766.x","volume":"58","author":"H Utsunomiya","year":"2003","unstructured":"Utsunomiya H, Suzuki T, Ito K, Moriya T, Konno R, Sato S, Yaegashi N, Okamura K, Sasano H (2003) The correlation between the response to progestogen treatment and the expression of progesterone receptor B and 17beta-hydroxysteroid dehydrogenase type 2 in human endometrial carcinoma. Clin Endocrinol (Oxf) 58(6):696\u2013703","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"3727_CR15","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3390\/ijms19020570","volume":"19","author":"M Morlando","year":"2018","unstructured":"Morlando M, Fatica A (2018) Alteration of epigenetic regulation by long noncoding RNAs in cancer. Int J Mol Sci 19(2):570","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3727_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tcb.2017.11.008","volume":"28","author":"C Lin","year":"2018","unstructured":"Lin C, Yang L (2018) Long noncoding RNA in cancer: wiring signaling circuitry. Trends Cell Biol 28(4):287\u2013301","journal-title":"Trends Cell Biol"},{"issue":"3","key":"3727_CR17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.molmed.2018.01.001","volume":"24","author":"G Arun","year":"2018","unstructured":"Arun G, Diermeier SD, Spector DL (2018) Therapeutic targeting of long non-coding RNAs in cancer. Trends Mol Med 24(3):257\u2013277","journal-title":"Trends Mol Med"},{"issue":"2","key":"3727_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00280-016-3208-2","volume":"79","author":"HY Zhang","year":"2017","unstructured":"Zhang HY, Liang F, Zhang JW, Wang F, Wang L, Kang XG (2017) Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205. Cancer Chemother Pharmacol 79(2):327\u2013337","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"3727_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3233\/CBM-181182","volume":"22","author":"L Wang","year":"2018","unstructured":"Wang L, Wang F, Na L, Yu J, Huang L, Meng ZQ, Chen Z, Chen H, Ming LL, Hua YQ (2018) LncRNA AB209630 inhibits gemcitabine resistance cell proliferation by regulating PI3K\/AKT signaling in pancreatic ductal adenocarcinoma. Cancer Biomark 22(1):169\u2013174","journal-title":"Cancer Biomark"},{"issue":"9","key":"3727_CR20","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1097\/IGC.0000000000000277","volume":"24","author":"QY You","year":"2014","unstructured":"You QY, Tao H, Ling B (2014) Long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) as a foe and novel potential therapeutic target for endometrial carcinoma. Int J Gynecol Cancer 24(9):1536","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"3727_CR21","first-page":"151","volume":"1856","author":"A Bhan","year":"2015","unstructured":"Bhan A, Mandal SS (2015) LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer. Biochim Biophys Acta 1856(1):151\u2013164","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"3727_CR22","doi-asserted-by":"publisher","first-page":"6822","DOI":"10.1002\/jcp.26432","volume":"233","author":"L Liu","year":"2018","unstructured":"Liu L, Cui S, Wan T, Li X, Tian W, Zhang R, Luo L, Shi Y (2018) Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p. J Cell Physiol 233(9):6822\u20136831","journal-title":"J Cell Physiol"},{"issue":"3","key":"3727_CR23","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1159\/000489110","volume":"46","author":"Z Xiao","year":"2018","unstructured":"Xiao Z, Qu Z, Chen Z, Fang Z, Zhou K, Huang Z, Guo X, Zhang Y (2018) LncRNA HOTAIR is a prognostic biomarker for the proliferation and chemoresistance of colorectal cancer via MiR-203a-3p-mediated Wnt\/\u00df-catenin signaling pathway. Cell Physiol Biochem 46(3):1275\u20131285","journal-title":"Cell Physiol Biochem"},{"issue":"4","key":"3727_CR24","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.bbrc.2018.02.141","volume":"497","author":"Y Yang","year":"2018","unstructured":"Yang Y, Jiang C, Yang Y, Guo L, Huang J, Liu X, Wu C, Zou J (2018) Silencing of LncRNA-HOTAIR decreases drug resistance of non-small cell lung cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1. Biochem Biophys Res Commun 497(4):1003\u20131010","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"3727_CR25","first-page":"7986","volume":"14","author":"JJ Zhou","year":"2017","unstructured":"Zhou JJ, Cheng D, He XY, Meng Z, Ye HL, Chen RF (2017) Knockdown of long non-coding RNA HOTAIR sensitizes hepatocellular carcinoma cell to cisplatin by suppressing the STAT3\/ABCB1 signaling pathway. Oncol Lett 14(6):7986\u20137992","journal-title":"Oncol Lett"},{"issue":"3","key":"3727_CR26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00280-016-2964-3","volume":"77","author":"C Shang","year":"2016","unstructured":"Shang C, Guo Y, Zhang H, Xue YX (2016) Long noncoding RNA HOTAIR is a prognostic biomarker and inhibits chemosensitivity to doxorubicin in bladder transitional cell carcinoma. Cancer Chemother Pharmacol 77(3):507\u2013513","journal-title":"Cancer Chemother Pharmacol"},{"issue":"17","key":"3727_CR27","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1007\/s00018-014-1580-9","volume":"71","author":"Y Chu","year":"2014","unstructured":"Chu Y, Wang Y, Zhang G, Chen H, Dowdy SC, Xiong Y, Liu F, Zhang R, Li J, Jiang SW (2014) Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. CMLS 71(17):3393\u20133408","journal-title":"CMLS"},{"issue":"4","key":"3727_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4149\/neo_2014_075","volume":"61","author":"B Cai","year":"2014","unstructured":"Cai B, Song XQ, Cai JP, Zhang S (2014) HOTAIR: a cancer-related long non-coding RNA. Neoplasma 61(4):379\u2013391","journal-title":"Neoplasma"},{"key":"3727_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.canlet.2017.03.038","volume":"398","author":"M Huang","year":"2017","unstructured":"Huang M, Chen C, Geng J, Han D, Wang T, Xie T, Wang L, Wang Y, Wang C, Lei Z, Chu X (2017) Targeting KDM1A attenuates Wnt\/beta-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett 398:12\u201321","journal-title":"Cancer Lett"},{"issue":"7","key":"3727_CR30","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.cell.2007.06.014","volume":"129","author":"CJ Woo","year":"2007","unstructured":"Woo CJ, Kingston RE (2007) HOTAIR lifts noncoding RNAs to new levels. Cell 129(7):1257\u20131259","journal-title":"Cell"},{"issue":"21","key":"3727_CR31","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1038\/onc.2015.340","volume":"35","author":"X Xue","year":"2016","unstructured":"Xue X, Yang YA, Zhang A, Fong KW, Kim J, Song B, Li S, Zhao JC, Yu J (2016) LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer. Oncogene 35(21):2746\u20132755","journal-title":"Oncogene"},{"issue":"1","key":"3727_CR32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.celrep.2015.08.069","volume":"13","author":"A Zhang","year":"2015","unstructured":"Zhang A, Zhao JC, Kim J, Fong KW, Yang YA, Chakravarti D, Mo YY, Yu J (2015) LncRNA HOTAIR enhances the androgen-receptor-mediated transcriptional program and drives castration-resistant prostate cancer. Cell Rep 13(1):209\u2013221","journal-title":"Cell Rep"},{"issue":"10","key":"3727_CR33","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1177\/1933719116689595","volume":"24","author":"L Nie","year":"2017","unstructured":"Nie L, Zhao YB, Pan JL, Lei Y, Liu M, Long Y, Zhang JH, Hu Y, Xu MQ, Yuan DZ, Yue LM (2017) Progesterone-induced miR-152 inhibits the proliferation of endometrial epithelial cells by downregulating WNT-1. Reprod Sci 24(10):1444\u20131453","journal-title":"Reprod Sci"},{"issue":"39","key":"3727_CR34","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1038\/onc.2016.56","volume":"35","author":"II Lee","year":"2016","unstructured":"Lee II, Maniar K, Lydon JP, Kim JJ (2016) Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells. Oncogene 35(39):5191\u20135201","journal-title":"Oncogene"},{"issue":"7","key":"3727_CR35","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41419-018-0768-6","volume":"9","author":"Y Yu","year":"2018","unstructured":"Yu Y, Zhang M, Wang N, Li Q, Yang J, Yan S, He X, Ji G, Miao L (2018) Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma. Cell Death Dis 9(7):746","journal-title":"Cell Death Dis"},{"issue":"6","key":"3727_CR36","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1159\/000489589","volume":"46","author":"Z Ma","year":"2018","unstructured":"Ma Z, Peng P, Zhou J, Hui B, Ji H, Wang J, Wang K (2018) Long non-coding RNA SH3PXD2A-AS1 promotes cell progression partly through epigenetic silencing P57 and KLF2 in colorectal cancer. Cell Physiol Biochem 46(6):2197\u20132214","journal-title":"Cell Physiol Biochem"},{"issue":"7","key":"3727_CR37","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119(7):941\u2013953","journal-title":"Cell"},{"issue":"7057","key":"3727_CR38","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature04020","volume":"437","author":"E Metzger","year":"2005","unstructured":"Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, Gunther T, Buettner R, Schule R (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437(7057):436\u2013439","journal-title":"Nature"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-018-3727-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-018-3727-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-018-3727-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:11:22Z","timestamp":1573758682000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-018-3727-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3727"],"URL":"https:\/\/doi.org\/10.1007\/s00280-018-3727-0","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"7 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants and animals were in accordance with the ethical standards of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}