{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:41:08Z","timestamp":1788050468394,"version":"build-2784847793"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00280-023-04620-w","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:02:17Z","timestamp":1707278537000},"page":"541-554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study"],"prefix":"10.1007","volume":"93","author":[{"given":"Ahmed O.","family":"ELKasar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Z.","family":"Hussien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala E.","family":"Abdel-Hamied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim G.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-9462","authenticated-orcid":false,"given":"Elsayed M.","family":"Mahgoup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr A.","family":"El-Arabey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel R.","family":"Abd-Allah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"4620_CR1","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1200\/JCO.2000.18.20.3558","volume":"18","author":"H Ozer","year":"2000","unstructured":"Ozer H et al (2000) 2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. American Society of Clinical Oncology Growth Factors Expert Panel. J Clin Oncol 18:3558\u201385","journal-title":"J Clin Oncol"},{"key":"4620_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/cncr.11882","volume":"100","author":"J Crawford","year":"2004","unstructured":"Crawford J, Dale DC, Lyman GH (2004) Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer 100:228\u201337","journal-title":"Cancer"},{"key":"4620_CR3","doi-asserted-by":"publisher","first-page":"691","DOI":"10.6004\/jnccn.2022.0030","volume":"20","author":"WJ Gradishar","year":"2022","unstructured":"Gradishar WJ et al (2022) 2022, Breast Cancer, version 3. NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 20:691\u2013722","journal-title":"J Natl Compr Canc Netw"},{"key":"4620_CR4","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1200\/JCO.2006.06.4451","volume":"24","author":"TJ Smith","year":"2006","unstructured":"Smith TJ et al (2006) 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 24:3187\u2013205","journal-title":"J Clin Oncol"},{"key":"4620_CR5","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/1471-2407-8-332","volume":"8","author":"A del Giglio","year":"2008","unstructured":"del Giglio A et al (2008) XM02 is superior to placebo and equivalent to Neupogen in reducing the duration of severe neutropenia and the incidence of febrile neutropenia in cycle 1 in breast cancer patients receiving docetaxel\/doxorubicin chemotherapy. BMC Cancer 8:332","journal-title":"BMC Cancer"},{"key":"4620_CR6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1056\/NEJM199107183250305","volume":"325","author":"J Crawford","year":"1991","unstructured":"Crawford J et al (1991) Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 325:164\u201370","journal-title":"N Engl J Med"},{"key":"4620_CR7","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0959-8049(93)90376-Q","volume":"29","author":"V Trillet-Lenoir","year":"1993","unstructured":"Trillet-Lenoir V et al (1993) Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy. Eur J Cancer 29:319\u201324","journal-title":"Eur J Cancer"},{"key":"4620_CR8","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1016\/j.ejca.2006.05.002","volume":"42","author":"MS Aapro","year":"2006","unstructured":"Aapro MS et al (2006) EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur J Cancer 42:2433\u201353","journal-title":"Eur J Cancer"},{"key":"4620_CR9","unstructured":"J Carr, Avon, Somerset and Wiltshire Cancer Services (2012) Guideline for the use of granulocyte-colony stimulating factor (G-CSF) in adult patients. Avon, Somerset and Wiltshire Cancer Services, vol 9, p 1"},{"key":"4620_CR10","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.6004\/jnccn.2015.0014","volume":"13","author":"MA Dinan","year":"2015","unstructured":"Dinan MA, Hirsch BR, Lyman GH (2015) Management of chemotherapy-induced neutropenia: measuring quality, cost, and value. J Natl Compr Canc Netw 13:e1-7","journal-title":"J Natl Compr Canc Netw"},{"key":"4620_CR11","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1177\/1060028017706373","volume":"51","author":"DC Moore","year":"2017","unstructured":"Moore DC, Pellegrino AE (2017) Pegfilgrastim-induced bone pain: a review on incidence, risk factors, and evidence-based management. Ann Pharmacother 51:797\u2013803","journal-title":"Ann Pharmacother"},{"key":"4620_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1385\/BTER:83:2:139","volume":"83","author":"ED Hager","year":"2001","unstructured":"Hager ED et al (2001) Effects of lithium on thrombopoiesis in patients with low platelet cell counts following chemotherapy or radiotherapy. Biol Trace Elem Res 83:139\u201348","journal-title":"Biol Trace Elem Res"},{"key":"4620_CR13","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1177\/030089168006600607","volume":"66","author":"A Scanni","year":"1980","unstructured":"Scanni A et al (1980) Lithium carbonate in the treatment of drug-induced leukopenia in patients with solid tumors. Tumori 66:729\u201337","journal-title":"Tumori"},{"key":"4620_CR14","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S0022-3476(80)80583-X","volume":"96","author":"PG Steinherz","year":"1980","unstructured":"Steinherz PG et al (1980) The effect of lithium carbonate on leukopenia after chemotherapy. J Pediatr 96:923\u20137","journal-title":"J Pediatr"},{"key":"4620_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/ajh.2830160402","volume":"16","author":"CM Richman","year":"1984","unstructured":"Richman CM et al (1984) The effect of lithium carbonate on chemotherapy-induced neutropenia and thrombocytopenia. Am J Hematol 16:313\u201323","journal-title":"Am J Hematol"},{"key":"4620_CR16","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/0002-9343(81)90831-7","volume":"70","author":"GH Lyman","year":"1981","unstructured":"Lyman GH et al (1981) Lithium carbonate in patients with small cell lung cancer receiving combination chemotherapy. Am J Med 70:1222\u20139","journal-title":"Am J Med"},{"key":"4620_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1189\/jlb.0608388","volume":"85","author":"D Focosi","year":"2009","unstructured":"Focosi D et al (2009) Lithium and hematology: established and proposed uses. J Leukoc Biol 85:20\u20138","journal-title":"J Leukoc Biol"},{"key":"4620_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4172\/2157-7013.1000270","volume":"8","author":"A Duvall","year":"2017","unstructured":"Duvall A, Gallicchio VS (2017) Lithium treatment in clinical medicine: history, current status and future use. J Cell Sci Ther 8:2","journal-title":"J Cell Sci Ther"},{"key":"4620_CR19","first-page":"199","volume":"108","author":"VS Gallicchio","year":"1986","unstructured":"Gallicchio VS et al (1986) In vivo and in vitro modulation of megakaryocytopoiesis and stromal colony formation by lithium. J Lab Clin Med 108:199\u2013205","journal-title":"J Lab Clin Med"},{"key":"4620_CR20","doi-asserted-by":"publisher","first-page":"7882","DOI":"10.1038\/sj.onc.1208068","volume":"23","author":"M Mazor","year":"2004","unstructured":"Mazor M et al (2004) Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. Oncogene 23:7882\u201392","journal-title":"Oncogene"},{"key":"4620_CR21","doi-asserted-by":"publisher","first-page":"241864","DOI":"10.1155\/2014\/241864","volume":"2014","author":"H Li","year":"2014","unstructured":"Li H et al (2014) Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS\/GSK-3\u03b2\/NF-\u03baB signaling pathway. Oxid Med Cell Longev 2014:241864","journal-title":"Oxid Med Cell Longev"},{"key":"4620_CR22","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1083\/jcb.200504035","volume":"170","author":"S Sarkar","year":"2005","unstructured":"Sarkar S et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 170:1101\u201311","journal-title":"J Cell Biol"},{"key":"4620_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF02993858","volume":"13","author":"AI Einzig","year":"1996","unstructured":"Einzig AI et al (1996) Phase II trial of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy: the Eastern Cooperative Oncology Group (ECOG) results of protocol E1293. Med Oncol 13:87\u201393","journal-title":"Med Oncol"},{"key":"4620_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.intimp.2006.08.011","volume":"7","author":"G Demir","year":"2007","unstructured":"Demir G et al (2007) Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol 7:113\u20136","journal-title":"Int Immunopharmacol"},{"key":"4620_CR25","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.7314\/APJCP.2014.15.14.5733","volume":"15","author":"A Ostadrahimi","year":"2014","unstructured":"Ostadrahimi A et al (2014) Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial. Asian Pac J Cancer Prev 15:5733\u20139","journal-title":"Asian Pac J Cancer Prev"},{"key":"4620_CR26","first-page":"58","volume":"10","author":"B Daneshfard","year":"2020","unstructured":"Daneshfard B et al (2020) Effect of chamomile on chemotherapy-induced neutropenia in pediatric leukemia patients: a randomized triple-blind placebo-controlled clinical trial. Avicenna J Phytomed 10:58\u201369","journal-title":"Avicenna J Phytomed"},{"key":"4620_CR27","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/pst.1709","volume":"15","author":"L Flight","year":"2016","unstructured":"Flight L, Julious SA (2016) Practical guide to sample size calculations: an introduction. Pharm Stat 15:68\u201374","journal-title":"Pharm Stat"},{"key":"4620_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2165\/00002018-199920030-00004","volume":"20","author":"M Gitlin","year":"1999","unstructured":"Gitlin M (1999) Lithium and the kidney: an updated review. Drug Saf 20:231\u201343","journal-title":"Drug Saf"},{"key":"4620_CR29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1600-0447.1982.tb00920.x","volume":"66","author":"P Plenge","year":"1982","unstructured":"Plenge P et al (1982) Lithium treatment: does the kidney prefer one daily dose instead of two? Acta Psychiatr Scand 66:121\u2013128","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"4620_CR30","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/jac5.1118","volume":"2","author":"J Hicks","year":"2019","unstructured":"Hicks J et al (2019) Precision pharmacotherapy: integrating pharmacogenomics into clinical pharmacy practice. J Am Coll Clin Pharm 2(3):303\u2013313","journal-title":"J Am Coll Clin Pharm"},{"key":"4620_CR31","unstructured":"US Department of Health and Human Services (2017) Common terminology criteria for adverse events (CTCAE). Version 4.0. National Institutes of Health, National Cancer Institute, 2010. https:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03\/Archive\/CTCAE_4.0_2009-05-29_QuickReference_8.5x11.pdf"},{"key":"4620_CR32","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1200\/JCO.2008.18.4028","volume":"27","author":"S Jones","year":"2009","unstructured":"Jones S et al (2009) Docetaxel with cyclophosphamide is associated with an overall survival benefit compared with doxorubicin and cyclophosphamide: 7-year follow-up of US oncology research trial 9735. J Clin Oncol 27:1177\u20131183","journal-title":"J Clin Oncol"},{"key":"4620_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12974\/2309-6160.2017.04.1","volume":"4","author":"R Fernandes","year":"2017","unstructured":"Fernandes R et al (2017) Primary febrile neutropenia prophylaxis for patients who receive FEC-D chemotherapy for breast cancer: a systematic review. J Glob Oncol 4:1\u20138","journal-title":"J Glob Oncol"},{"key":"4620_CR34","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1200\/JCO.2015.62.3488","volume":"33","author":"TJ Smith","year":"2015","unstructured":"Smith TJ et al (2015) Recommendations for the use of WBC growth factors: American Society of Clinical Oncology Clinical Practice Guideline update. J Clin Oncol 33:3199\u2013212","journal-title":"J Clin Oncol"},{"key":"4620_CR35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00520-015-2805-7","volume":"24","author":"C Skedgel","year":"2016","unstructured":"Skedgel C, Rayson D, Younis T (2016) Is febrile neutropenia prophylaxis with granulocyte-colony stimulating factors economically justified for adjuvant TC chemotherapy in breast cancer? Support Care Cancer 24:387\u2013394","journal-title":"Support Care Cancer"},{"key":"4620_CR36","unstructured":"Amgen Inc. (2000) Neupogen (filgrastim) prescribing information. Amgen Inc., Thousand Oaks"},{"key":"4620_CR37","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1179\/1607845412Y.0000000049","volume":"18","author":"R Ria","year":"2013","unstructured":"Ria R et al (2013) Neutropenia and G-CSF in lymphoproliferative diseases. Hematology 18:131\u20137","journal-title":"Hematology"},{"key":"4620_CR38","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394\u2013424","journal-title":"CA Cancer J Clin"},{"key":"4620_CR39","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1056\/NEJM198003273021303","volume":"302","author":"LJ Levitt","year":"1980","unstructured":"Levitt LJ, Quesenberry PJ (1980) The effect of lithium on murine hematopoiesis in a liquid culture system. N Engl J Med 302:713\u20139","journal-title":"N Engl J Med"},{"key":"4620_CR40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1365-2141.1984.tb03958.x","volume":"56","author":"RA Joyce","year":"1984","unstructured":"Joyce RA (1984) Sequential effects of lithium on haematopoiesis. Br J Haematol 56:307\u201321","journal-title":"Br J Haematol"},{"key":"4620_CR41","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.2146\/ajhp060319","volume":"64","author":"EC Kutscher","year":"2007","unstructured":"Kutscher EC et al (2007) Clozapine-induced leukopenia successfully treated with lithium. Am J Health Syst Pharm 64:2027\u201331","journal-title":"Am J Health Syst Pharm"},{"key":"4620_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/2045125315624063","volume":"6","author":"M Aydin","year":"2016","unstructured":"Aydin M et al (2016) Continuing clozapine treatment with lithium in schizophrenic patients with neutropenia or leukopenia: brief review of literature with case reports. Ther Adv Psychopharmacol 6:33\u20138","journal-title":"Ther Adv Psychopharmacol"},{"key":"4620_CR43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1365-2141.1998.00537.x","volume":"100","author":"A Ballin","year":"1998","unstructured":"Ballin A et al (1998) Increased number of peripheral blood CD34+ cells in lithium-treated patients. Br J Haematol 100:219\u201321","journal-title":"Br J Haematol"},{"key":"4620_CR44","first-page":"234","volume":"52","author":"A Turner","year":"1978","unstructured":"Turner A, Allalunis M (1978) Mononuclear cell production of colony stimulating activity in humans taking oral lithium carbonate. Blood 52:234","journal-title":"Blood"},{"key":"4620_CR45","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/cancers15041095","volume":"15","author":"C Yang","year":"2023","unstructured":"Yang C et al (2023) Lithium in cancer therapy: friend or foe? Cancers (Basel) 15:1095","journal-title":"Cancers (Basel)"},{"key":"4620_CR46","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1192\/bjp.135.3.255","volume":"135","author":"EP Worrall","year":"1979","unstructured":"Worrall EP et al (1979) Controlled studies of the acute antidepressant effects of lithium. Br J Psychiatry 135:255\u201362","journal-title":"Br J Psychiatry"},{"key":"4620_CR47","first-page":"537","volume":"13","author":"EY Villegas-V\u00e1zquez","year":"2023","unstructured":"Villegas-V\u00e1zquez EY et al (2023) Lithium: a promising anticancer agent. Life (Basel) 13:537","journal-title":"Life (Basel)"},{"key":"4620_CR48","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1600-0447.1976.tb00067.x","volume":"53","author":"PB Vendsborg","year":"1976","unstructured":"Vendsborg PB, Bech P, Rafaelsen OJ (1976) Lithium treatment and weight gain. Acta Psychiatr Scand 53:139\u201347","journal-title":"Acta Psychiatr Scand"},{"key":"4620_CR49","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.yexcr.2004.08.001","volume":"300","author":"E Beurel","year":"2004","unstructured":"Beurel E et al (2004) GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas\/APO-1) expression. Exp Cell Res 300:354\u201364","journal-title":"Exp Cell Res"},{"key":"4620_CR50","doi-asserted-by":"publisher","first-page":"6039","DOI":"10.1074\/jbc.274.10.6039","volume":"274","author":"RW Chen","year":"1999","unstructured":"Chen RW, Chuang DM (1999) Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem 274:6039\u201342","journal-title":"J Biol Chem"},{"key":"4620_CR51","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/378785a0","volume":"378","author":"DA Cross","year":"1995","unstructured":"Cross DA et al (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785\u20139","journal-title":"Nature"},{"key":"4620_CR52","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0006-8993(01)03005-0","volume":"919","author":"TD King","year":"2001","unstructured":"King TD, Bijur GN, Jope RS (2001) Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res 919:106\u201314","journal-title":"Brain Res"},{"key":"4620_CR53","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.it.2011.06.008","volume":"32","author":"CD Sadik","year":"2011","unstructured":"Sadik CD, Kim ND, Luster AD (2011) Neutrophils cascading their way to inflammation. Trends Immunol 32:452\u201360","journal-title":"Trends Immunol"},{"key":"4620_CR54","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3389\/fimmu.2020.01259","volume":"11","author":"A Capucetti","year":"2020","unstructured":"Capucetti A, Albano F, Bonecchi R (2020) Multiple roles for chemokines in neutrophil biology. Front Immunol 11:1259","journal-title":"Front Immunol"},{"key":"4620_CR55","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/sj.bmt.1705872","volume":"41","author":"RE Kast","year":"2008","unstructured":"Kast RE (2008) How lithium treatment generates neutrophilia by enhancing phosphorylation of GSK-3, increasing HIF-1 levels and how this path is important during engraftment. Bone Marrow Transplant 41:23\u20136","journal-title":"Bone Marrow Transplant"},{"key":"4620_CR56","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1182\/blood-2004-01-0272","volume":"106","author":"CL Semerad","year":"2005","unstructured":"Semerad CL et al (2005) G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 106:3020\u20137","journal-title":"Blood"},{"key":"4620_CR57","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000350282","volume":"5","author":"N Strydom","year":"2013","unstructured":"Strydom N, Rankin SM (2013) Regulation of circulating neutrophil numbers under homeostasis and in disease. J Innate Immun 5:304\u201314","journal-title":"J Innate Immun"},{"key":"4620_CR58","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1161\/CIRCRESAHA.116.304918","volume":"116","author":"A Anzai","year":"2015","unstructured":"Anzai A et al (2015) Adventitial CXCL1\/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture. Circ Res 116:612\u201323","journal-title":"Circ Res"},{"key":"4620_CR59","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1007\/s11095-014-1429-9","volume":"31","author":"AL Quartino","year":"2014","unstructured":"Quartino AL et al (2014) Characterization of endogenous G-CSF and the inverse correlation to chemotherapy-induced neutropenia in patients with breast cancer using population modeling. Pharm Res 31:3390\u2013403","journal-title":"Pharm Res"},{"key":"4620_CR60","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/hon.2900070108","volume":"7","author":"JH Scarffe","year":"1989","unstructured":"Scarffe JH, Chang J (1989) Failure of lithium to reduce period of neutropenia during induction therapy of acute myeloid leukemia. Hematol Oncol 7:69\u201375","journal-title":"Hematol Oncol"},{"key":"4620_CR61","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/978-1-4757-0259-0_21","volume":"127","author":"WA Robinson","year":"1980","unstructured":"Robinson WA et al (1980) In vivo and in vitro effects of lithium on granulopoiesis in human neutropenic disorders. Adv Exp Med Biol 127:281\u201391","journal-title":"Adv Exp Med Biol"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-023-04620-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00280-023-04620-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-023-04620-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T13:02:05Z","timestamp":1716814925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00280-023-04620-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["4620"],"URL":"https:\/\/doi.org\/10.1007\/s00280-023-04620-w","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"20 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study complied with the ethical standards as laid down in the 1964 Declaration of Helsinki and was approved by the Research Ethical Committee of Al-Azhar University prior to patient enrollment. All patients provided written informed consent prior to enrollment in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}