{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:08:31Z","timestamp":1791666511129,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["American Lebanese Syrian Associated Charities"],"award-info":[{"award-number":["American Lebanese Syrian Associated Charities"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00280-024-04653-9","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T09:02:23Z","timestamp":1709110943000},"page":"617-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ommaya reservoir use in pediatric ALL and NHL: a review at St. Jude Children\u2019s Research Hospital"],"prefix":"10.1007","volume":"93","author":[{"given":"Alyssa","family":"Gaietto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Panetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Pauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V","family":"Relling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Ehrhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hon","family":"Pui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2490-9655","authenticated-orcid":false,"given":"Hope D","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"issue":"4","key":"4653_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1056\/NEJM197507242930402","volume":"293","author":"WR Shapiro","year":"1975","unstructured":"Shapiro WR, Young DF, Mehta BM (1975) Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. N Engl J Med 293(4):161\u2013166","journal-title":"N Engl J Med"},{"issue":"1\u20132","key":"4653_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/02841866909134434","volume":"8","author":"SA Kieffer","year":"1969","unstructured":"Kieffer SA, Stadlan EM, D\u2019Angio GJ (1969) Anatomic studies of the distribution and effects of intrathecal radioactive gold. Acta Radiol Ther Phys Biol 8(1\u20132):27\u201337","journal-title":"Acta Radiol Ther Phys Biol"},{"issue":"4","key":"4653_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1056\/NEJM197301252880412","volume":"288","author":"JB Posner","year":"1973","unstructured":"Posner JB (1973) Reservoirs for intraventricular chemotherapy. N Engl J Med 288(4):212","journal-title":"N Engl J Med"},{"key":"4653_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1017\/S0317167100030432","volume":"17","author":"RG Perrin","year":"1990","unstructured":"Perrin RG, Lishner M, Guha A et al (1990) Experience with Ommaya reservoir in 120 consecutive patients with meningeal malignancy. Can J Neurol Sci 17:190\u2013192","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"4653_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11060-014-1531-1","volume":"120","author":"A Peyrl","year":"2014","unstructured":"Peyrl A, Chocholous M, Azizi AA et al (2014) Safety of Ommaya reservoirs in children with brain tumors: a 20-year experience with 5472 intraventricular drug administrations in 98 patients. J Neurooncol 120(1):139\u2013145","journal-title":"J Neurooncol"},{"issue":"3","key":"4653_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jinf.2013.12.002","volume":"68","author":"AD Szvalb","year":"2014","unstructured":"Szvalb AD, Raad II, Weinberg JS et al (2014) Ommaya reservoir-related infections: clinical manifestations and treatment outcomes. J Infect 68(3):216\u2013224","journal-title":"J Infect"},{"issue":"3","key":"4653_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jinf.2013.11.014","volume":"68","author":"PA Mead","year":"2014","unstructured":"Mead PA, Safdieh JE, Nizza P et al (2014) Ommaya reservoir infections: a 16-year retrospective analysis. J Infect 68(3):225\u2013230","journal-title":"J Infect"},{"issue":"1","key":"4653_CR8","first-page":"49","volume":"47","author":"DI Sandberg","year":"2000","unstructured":"Sandberg DI, Bilsky MH, Souweidane MM et al (2000) Ommaya reservoirs for the treatment of leptomeningeal metastases. Neurosurgery 47(1):49\u201355","journal-title":"Neurosurgery"},{"issue":"19","key":"4653_CR9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1056\/NEJM196811072791904","volume":"279","author":"RA Ratcheson","year":"1968","unstructured":"Ratcheson RA, Ommaya AK (1968) Experience with the subcutaneous cerebrospinal-fluid reservoir. Preliminary report of 60 cases. N Engl J Med 279(19):1025\u20131031","journal-title":"N Engl J Med"},{"issue":"5","key":"4653_CR10","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1182\/blood.V51.5.835.835","volume":"51","author":"WA Bleyer","year":"1978","unstructured":"Bleyer WA, Poplack DG, Simon RM (1978) Concentration x time methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms. Blood 51(5):835\u2013842","journal-title":"Blood"},{"issue":"3","key":"4653_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/mpo.2950060304","volume":"6","author":"WA Bleyer","year":"1979","unstructured":"Bleyer WA, Poplack DG (1979) Intraventricular versus intra lumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. Med Pediatr Oncol 6(3):207\u2013213","journal-title":"Med Pediatr Oncol"},{"issue":"5","key":"4653_CR12","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3171\/jns.1997.87.5.0694","volume":"87","author":"MC Chamberlain","year":"1997","unstructured":"Chamberlain MC, Kormanik PA, Barba D (1997) Complications associated with intraventricular chemotherapy in patients with leptomeningeal metastases. J Neurosurg 87(5):694\u2013699","journal-title":"J Neurosurg"},{"issue":"2","key":"4653_CR13","first-page":"147","volume":"4","author":"DM Green","year":"1982","unstructured":"Green DM, West CR, Brecher ML et al (1982) The use of subcutaneous cerebrospinal fluid reservoirs for the prevention and treatment of meningeal relapse of acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol 4(2):147\u2013154","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"2","key":"4653_CR14","first-page":"111","volume":"1","author":"M Haghbin","year":"1979","unstructured":"Haghbin M, Galicich JH (1979) Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia. Am J Pediatr Hematol Oncol 1(2):111\u2013117","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"2","key":"4653_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<511::AID-CNCR33>3.0.CO;2-H","volume":"85","author":"AM Moser","year":"1999","unstructured":"Moser AM, Adamson PC, Gillespie AJ et al (1999) Intraventricular concentration times time (C x T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma. Cancer 85(2):511\u2013516","journal-title":"Cancer"},{"issue":"4","key":"4653_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1600-0609.1978.tb02460.x","volume":"20","author":"AS Spiers","year":"1978","unstructured":"Spiers AS, Booth AE, Firth JL (1978) Subcutaneous cerebrospinal fluid reservoirs in patients with acute leukaemia. Scan J Haematol 20(4):289\u2013296","journal-title":"Scan J Haematol"},{"issue":"9","key":"4653_CR17","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1200\/JCO.1985.3.9.1217","volume":"3","author":"P Steinherz","year":"1985","unstructured":"Steinherz P, Jereb B, Galicich J (1985) Therapy of CNS leukemia with intraventricular chemotherapy and low-dose neuraxis radiotherapy. J Clin Oncol 3(9):1217\u20131226","journal-title":"J Clin Oncol"},{"issue":"11","key":"4653_CR18","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1200\/JCO.1989.7.11.1741","volume":"7","author":"DR Strother","year":"1989","unstructured":"Strother DR, Glynn-Barnhart A, Kovnar E et al (1989) Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing. J Clin Oncol 7(11):1741\u20131747","journal-title":"J Clin Oncol"},{"issue":"4","key":"4653_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s40272-018-0298-9","volume":"20","author":"R Wilson","year":"2018","unstructured":"Wilson R, Osborne C, Halsey C (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Paediatr Drugs 20(4):293\u2013301","journal-title":"Paediatr Drugs"},{"issue":"8","key":"4653_CR20","first-page":"1419","volume":"61","author":"AW Bleyer","year":"1977","unstructured":"Bleyer AW (1977) Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics. Cancer Treat Rep 61(8):1419\u20131425","journal-title":"Cancer Treat Rep"},{"issue":"90","key":"4653_CR21","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1002\/1097-0142(19821101)50:9<1676::AID-CNCR2820500903>3.0.CO;2-S","volume":"50","author":"LJ Ettinger","year":"1982","unstructured":"Ettinger LJ, Chervinsky DS, Freeman AI et al (1982) Pharmacokinetics of methotrexate following intravenous and intraventricular administration in acute lymphocytic leukemia and Non-hodgkin\u2019s lymphoma. Cancer 50(90):1676\u20131682","journal-title":"Cancer"},{"issue":"2","key":"4653_CR22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00280-013-2206-x","volume":"72","author":"JL Pauley","year":"2013","unstructured":"Pauley JL, Panetta JC, Crews KR et al (2013) Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments. Cancer Chemother Pharmacol 72(2):369\u2013378","journal-title":"Cancer Chemother Pharmacol"},{"issue":"15","key":"4653_CR23","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1056\/NEJM197310112891503","volume":"289","author":"WA Bleyer","year":"1973","unstructured":"Bleyer WA, Drake JC, Chabner BA (1973) Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. N Engl J Med 289(15):770\u2013773","journal-title":"N Engl J Med"},{"issue":"11","key":"4653_CR24","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1172\/JCI106181","volume":"48","author":"WM Hryniuk","year":"1969","unstructured":"Hryniuk WM, Bertino JR (1969) Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates. J Clin Invest 48(11):2140\u20132155","journal-title":"J Clin Invest"},{"issue":"5","key":"4653_CR25","first-page":"1641","volume":"42","author":"DA Keefe","year":"1982","unstructured":"Keefe DA, Capizzi RL, Rudnick SA (1982) Methotrexate cytotoxicity for L5178Y\/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability. Cancer Res 42(5):1641\u20131645","journal-title":"Cancer Res"},{"issue":"8","key":"4653_CR26","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1056\/NEJM197508212930807","volume":"293","author":"AM Mauer","year":"1975","unstructured":"Mauer AM (1975) Cell kinetics and practical consequences for therapy of acute leukemia. N Engl J Med 293(8):389\u2013393","journal-title":"N Engl J Med"},{"issue":"9","key":"4653_CR27","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1200\/JCO.2013.53.0808","volume":"32","author":"D Bhojwani","year":"2014","unstructured":"Bhojwani D, Sabin ND, Pei D et al (2014) Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Oncol 32(9):949\u2013959","journal-title":"J Clin Oncol"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-024-04653-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00280-024-04653-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-024-04653-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T17:02:43Z","timestamp":1716829363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00280-024-04653-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["4653"],"URL":"https:\/\/doi.org\/10.1007\/s00280-024-04653-9","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"26 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}