{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:51:20Z","timestamp":1775890280159,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"crossref","award":["2023-JC-QN-0992"],"award-info":[{"award-number":["2023-JC-QN-0992"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Project of General Medical Research","award":["TYYLKYJJ-2023-014"],"award-info":[{"award-number":["TYYLKYJJ-2023-014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00280-025-04807-3","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T08:59:16Z","timestamp":1759222756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High MCM10 expression mediates TMZ resistance and promotes the progression of glioma"],"prefix":"10.1007","volume":"95","author":[{"given":"Qiusi","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"4807_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1446428","volume":"11","author":"S Chen","year":"2024","unstructured":"Chen S, Jiang Y, Wang C, Tong S, He Y, Lu W et al (2024) Epigenetic clocks and gliomas: unveiling the molecular interactions between aging and tumor development. Front Mol Biosci 11:1446428","journal-title":"Front Mol Biosci"},{"key":"4807_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102585","volume":"36","author":"L Rodr\u00edguez Aguilar","year":"2021","unstructured":"Rodr\u00edguez Aguilar L, Vilchez ML, Milla Sanabria LN (2021) Targeting glioblastoma stem cells: the first step of photodynamic therapy. Photodiagnosis Photodyn Ther 36:102585","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"4807_CR3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69544","author":"RP Fuchs","year":"2021","unstructured":"Fuchs RP, Isogawa A, Paulo JA, Onizuka K, Takahashi T, Amunugama R et al (2021) Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide. Elife. https:\/\/doi.org\/10.7554\/eLife.69544","journal-title":"Elife"},{"key":"4807_CR4","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1080\/15384047.2019.1599662","volume":"20","author":"A Arora","year":"2019","unstructured":"Arora A, Somasundaram K (2019) Glioblastoma vs temozolomide: can the red queen race be won? Cancer Biol Ther 20:1083\u20131090","journal-title":"Cancer Biol Ther"},{"key":"4807_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143567","author":"O Honc","year":"2023","unstructured":"Honc O, Novotny J (2023) Methadone potentiates the cytotoxicity of temozolomide by impairing calcium homeostasis and dysregulation of PARP in glioblastoma cells. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers15143567","journal-title":"Cancers (Basel)"},{"key":"4807_CR6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jpba.2018.09.019","volume":"162","author":"MA El Mubarak","year":"2019","unstructured":"El Mubarak MA, Stylos EK, Chatziathanasiadou MV, Danika C, Alexiou GA, Tsekeris P et al (2019) Development and validation of simple step protein precipitation UHPLC-MS\/MS methods for quantitation of temozolomide in cancer patient plasma samples. J Pharm Biomed Anal 162:164\u2013170","journal-title":"J Pharm Biomed Anal"},{"key":"4807_CR7","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s12031-020-01486-y","volume":"70","author":"P Kang","year":"2020","unstructured":"Kang P, Han Z, Liao Z, Zhang H, Jia W, Tian Y (2020) Knockdown of MCM10 gene impairs glioblastoma cell proliferation, migration and invasion and the implications for the regulation of tumorigenesis. J Mol Neurosci 70:759\u2013768","journal-title":"J Mol Neurosci"},{"key":"4807_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.625899","volume":"11","author":"M Chakravarty","year":"2021","unstructured":"Chakravarty M, Ganguli P, Murahari M, Sarkar RR, Peters GJ, Mayur YC (2021) Study of combinatorial drug synergy of novel acridone derivatives with temozolomide using in-silico and in-vitro methods in the treatment of drug-resistant glioma. Front Oncol 11:625899","journal-title":"Front Oncol"},{"key":"4807_CR9","first-page":"1349","volume":"55","author":"M Wang","year":"2019","unstructured":"Wang M, Xie S, Yuan W, Xie T, Jamal M, Huang J et al (2019) Minichromosome maintenance protein 10 as a marker for proliferation and prognosis in lung cancer. Int J Oncol 55:1349\u20131360","journal-title":"Int J Oncol"},{"key":"4807_CR10","first-page":"6451","volume":"15","author":"MA Abdel-Maksoud","year":"2023","unstructured":"Abdel-Maksoud MA, Iqbal K, Gull S, Kumar SK, Mastoor M, Almutairi SM et al (2023) Immune modulation and prognostic significance of MCM10 in pan-cancer: a comprehensive analysis. Am J Transl Res 15:6451\u20136463","journal-title":"Am J Transl Res"},{"key":"4807_CR11","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/cas.14776","volume":"112","author":"T Murayama","year":"2021","unstructured":"Murayama T, Takeuchi Y, Yamawaki K, Natsume T, Li M, Marcela RN et al (2021) MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells. Cancer Sci 112:1209\u20131224","journal-title":"Cancer Sci"},{"key":"4807_CR12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1124\/mol.119.116137","volume":"96","author":"KY Chong","year":"2019","unstructured":"Chong KY, Kang M, Garofalo F, Ueno D, Liang H, Cady S et al (2019) Inhibition of heat shock protein 90 suppresses TWIST1 transcription. Mol Pharmacol 96:168\u2013179","journal-title":"Mol Pharmacol"},{"key":"4807_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107969","volume":"230","author":"L Zhang","year":"2022","unstructured":"Zhang L, Kuca K, You L, Zhao Y, Musilek K, Nepovimova E et al (2022) Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacol Ther 230:107969","journal-title":"Pharmacol Ther"},{"key":"4807_CR14","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/s41467-021-21407-w","volume":"12","author":"N Ochocka","year":"2021","unstructured":"Ochocka N, Segit P, Walentynowicz KA, Wojnicki K, Cyranowski S, Swatler J et al (2021) Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages. Nat Commun 12:1151","journal-title":"Nat Commun"},{"key":"4807_CR15","doi-asserted-by":"publisher","first-page":"32569","DOI":"10.1074\/jbc.M314017200","volume":"279","author":"M Izumi","year":"2004","unstructured":"Izumi M, Yatagai F, Hanaoka F (2004) Localization of human Mcm10 is spatially and temporally regulated during the S phase. J Biol Chem 279:32569\u201332577","journal-title":"J Biol Chem"},{"key":"4807_CR16","doi-asserted-by":"publisher","first-page":"5879","DOI":"10.1074\/jbc.M115.707802","volume":"291","author":"ME Douglas","year":"2016","unstructured":"Douglas ME, Diffley JFX (2016) Recruitment of Mcm10 to sites of replication initiation requires direct binding to the minichromosome maintenance (MCM) complex. J Biol Chem 291:5879\u20135888","journal-title":"J Biol Chem"},{"key":"4807_CR17","doi-asserted-by":"publisher","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","volume":"46","author":"SV Vasaikar","year":"2018","unstructured":"Vasaikar SV, Straub P, Wang J, Zhang B (2018) Linkedomics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res 46:D956\u2013D963","journal-title":"Nucleic Acids Res"},{"key":"4807_CR18","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/epi-2017-0118","volume":"10","author":"V Modhukur","year":"2018","unstructured":"Modhukur V, Iljasenko T, Metsalu T, Lokk K, Laisk-Podar T, Vilo J (2018) Methsurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics 10:277\u2013288","journal-title":"Epigenomics"},{"key":"4807_CR19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.31083\/j.fbl2903104","volume":"29","author":"QS Tian","year":"2024","unstructured":"Tian QS, Cheng J, Bao ZJ (2024) NOP14 as a potential predictor of adult-type diffuse glioma prognosis and immunotherapy, is related to cell migration, proliferation, and CD8(+)T cell infiltration. Front Biosci (Landmark Ed) 29:104","journal-title":"Front Biosci (Landmark Ed)"},{"key":"4807_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/med.21408","volume":"37","author":"IC Iser","year":"2017","unstructured":"Iser IC, Pereira MB, Lenz G, Wink MR (2017) The epithelial-to-mesenchymal transition-like process in glioblastoma: an updated systematic review and in silico investigation. Med Res Rev 37:271\u2013313","journal-title":"Med Res Rev"},{"key":"4807_CR21","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/s41588-022-01173-1","volume":"54","author":"S Deng","year":"2022","unstructured":"Deng S, Zhang J, Su J, Zuo Z, Zeng L, Liu K et al (2022) RNA m6a regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet 54:1427\u20131437","journal-title":"Nat Genet"},{"key":"4807_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.molcel.2004.09.017","volume":"16","author":"RM Ricke","year":"2004","unstructured":"Ricke RM, Bielinsky AK (2004) Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol Cell 16:173\u2013185","journal-title":"Mol Cell"},{"key":"4807_CR23","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3233\/THC-220576","volume":"31","author":"QS Tian","year":"2023","unstructured":"Tian QS, Zhang Q, Huang W (2023) MCM10 as a novel prognostic biomarker and its relevance to immune infiltration in gliomas. Technol Health Care 31:1301\u20131317","journal-title":"Technol Health Care"},{"issue":"1","key":"4807_CR24","doi-asserted-by":"publisher","first-page":"119227","DOI":"10.1016\/j.lfs.2021.119227","volume":"272","author":"Y Lei","year":"2021","unstructured":"Lei Y, Wang S, Liu J, Yan W, Han P, Tian D (2021) Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments. Life Sci 272(1):119227","journal-title":"Life Sci"},{"issue":"26","key":"4807_CR25","volume":"24","author":"L Cheng","year":"2020","unstructured":"Cheng L, Tan Z, Huang Z, Pan Y, Zhang W, Wang J (2020) Expression profile and prognostic values of mini-chromosome maintenance families (MCMs) in breast cancer. Med Sci Monit 24(26):e923673","journal-title":"Med Sci Monit"},{"key":"4807_CR26","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1007\/s11010-021-04060-1","volume":"476","author":"D Bordoloi","year":"2021","unstructured":"Bordoloi D, Padmavathi G, Banik K, Devi KA, Harsha C, Girisa S et al (2021) Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. Mol Cell Biochem 476:3303\u20133318","journal-title":"Mol Cell Biochem"},{"key":"4807_CR27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s11658-021-00282-9","volume":"26","author":"G Khalili-Tanha","year":"2021","unstructured":"Khalili-Tanha G, Moghbeli M (2021) Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells. Cell Mol Biol Lett 26:39","journal-title":"Cell Mol Biol Lett"},{"key":"4807_CR28","doi-asserted-by":"publisher","first-page":"9918379","DOI":"10.1155\/2021\/9918379","volume":"2021","author":"I Chattopadhyay","year":"2021","unstructured":"Chattopadhyay I, Ambati R, Gundamaraju R (2021) Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer. Mediators Inflamm 2021:9918379","journal-title":"Mediators Inflamm"},{"key":"4807_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117714","volume":"181","author":"J Yuan","year":"2024","unstructured":"Yuan J, Yang L, Zhang H, Beeraka NM, Zhang D, Wang Q et al (2024) Decoding tumor microenvironment: EMT modulation in breast cancer metastasis and therapeutic resistance, and implications of novel immune checkpoint blockers. Biomed Pharmacother 181:117714","journal-title":"Biomed Pharmacother"},{"key":"4807_CR30","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1080\/15384101.2021.1933303","volume":"20","author":"Y Nan","year":"2021","unstructured":"Nan Y, Guo L, Lu Y, Guo G, Hong R, Zhao L et al (2021) MiR-451 suppresses EMT and metastasis in glioma cells. Cell Cycle 20:1270\u20131278","journal-title":"Cell Cycle"},{"key":"4807_CR31","doi-asserted-by":"crossref","unstructured":"Babu D, Mudiraj A, Yadav N, Y BVKC, Panigrahi M, Prakash Babu P (2021) Rabeprazole has efficacy per se and reduces resistance to temozolomide in glioma via EMT inhibition. Cell Oncol (Dordr)44:889\u2013905","DOI":"10.1007\/s13402-021-00609-w"},{"key":"4807_CR32","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.3892\/or.2016.5098","volume":"36","author":"XH Zhang","year":"2016","unstructured":"Zhang XH, Qian Y, Li Z, Zhang NN, Xie YJ (2016) Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma. Oncol Rep 36:2967\u20132975","journal-title":"Oncol Rep"},{"key":"4807_CR33","doi-asserted-by":"publisher","first-page":"17701","DOI":"10.1038\/s41598-023-44946-2","volume":"13","author":"D Chen","year":"2023","unstructured":"Chen D, Zhong N, Guo Z, Ji Q, Dong Z, Zheng J et al (2023) MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer. Sci Rep 13:17701","journal-title":"Sci Rep"},{"key":"4807_CR34","doi-asserted-by":"publisher","first-page":"13008","DOI":"10.1074\/jbc.M117.779371","volume":"292","author":"M Izumi","year":"2017","unstructured":"Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N et al (2017) The Mcm2\u20137-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. J Biol Chem 292:13008\u201313021","journal-title":"J Biol Chem"},{"key":"4807_CR35","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.plaphy.2010.03.013","volume":"48","author":"V Baev","year":"2010","unstructured":"Baev V, Naydenov M, Apostolova E, Ivanova D, Doncheva S, Minkov I et al (2010) Identification of RNA-dependent DNA-methylation regulated promoters in Arabidopsis. Plant Physiol Biochem 48:393\u2013400","journal-title":"Plant Physiol Biochem"},{"key":"4807_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/genes8080198","author":"PCK Au","year":"2017","unstructured":"Au PCK, Dennis ES, Wang MB (2017) Analysis of argonaute 4-associated long non-coding RNA in Arabidopsis thaliana sheds novel insights into gene regulation through RNA-directed DNA methylation. Genes. https:\/\/doi.org\/10.3390\/genes8080198","journal-title":"Genes"},{"key":"4807_CR37","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1093\/nar\/gkt131","volume":"41","author":"ST Fatoba","year":"2013","unstructured":"Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J et al (2013) Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Nucleic Acids Res 41:4065\u20134079","journal-title":"Nucleic Acids Res"}],"updated-by":[{"DOI":"10.1007\/s00280-026-04873-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000}}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-025-04807-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00280-025-04807-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-025-04807-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:04:11Z","timestamp":1775887451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00280-025-04807-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["4807"],"URL":"https:\/\/doi.org\/10.1007\/s00280-025-04807-3","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised to update the Figures 2D and 8D.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00280-026-04873-1","URL":"https:\/\/doi.org\/10.1007\/s00280-026-04873-1","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All animal experiments have been reviewed and approved by the Ethics Committee of the 3201 Hospital (ACUC number: TYYLKYJJ-2022\u2013014).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"93"}}