{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:51:22Z","timestamp":1792122682764,"version":"4.4.0"},"reference-count":165,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"DOI":"10.1007\/s00280-025-04859-5","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:12:44Z","timestamp":1770099164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The potential and promise of natural antioxidants as epigenetic modulators in oral squamous cell carcinoma"],"prefix":"10.1007","volume":"96","author":[{"given":"Meenakshi","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Gangwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal Raj","family":"Rajaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhimanyu Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudheer D. V. N.","family":"Pamidimarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"4859_CR1","first-page":"67","volume":"8","author":"S Givony","year":"2020","unstructured":"Givony S (2020) Oral squamous cell carcinoma (OSCC) an overview. J Med Sci 8:67\u201374","journal-title":"J Med Sci"},{"issue":"1","key":"4859_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","volume":"15","author":"Y Tan","year":"2023","unstructured":"Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C (2023) Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci 15(1):44","journal-title":"Int J Oral Sci"},{"issue":"3","key":"4859_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s13193-023-01750-8","volume":"14","author":"J Riju","year":"2023","unstructured":"Riju J, Tirkey AJ, Vidya K, Agarwal M, Babu M, Kurian R, Paulose A (2023) A site-based analysis of relationship between clinicopathological factors and their influence on locoregional recurrence in oral squamous cell carcinoma. Indian J Surg Oncol 14(3):733\u2013741","journal-title":"Indian J Surg Oncol"},{"issue":"3","key":"4859_CR4","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"4859_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2023.1292720","volume":"4","author":"O Davaatsend","year":"2023","unstructured":"Davaatsend O, Altannamar M, Batbayar B, Jagdagsuren U (2023) Factors influencing the 5-year survival rate of oral cancer patients in the Mongolian population: a retrospective cohort study. Front Oral Health 4:1292720","journal-title":"Front Oral Health"},{"issue":"1","key":"4859_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40902-024-00410-3","volume":"46","author":"MJ Kim","year":"2024","unstructured":"Kim MJ, Ahn KM (2024) Prognostic factors of oral squamous cell carcinoma: the importance of recurrence and pTNM stage. Maxillofac Plast Reconstr Surg 46(1):8","journal-title":"Maxillofac Plast Reconstr Surg"},{"issue":"11","key":"4859_CR7","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.3390\/app10113896","volume":"10","author":"G Tenore","year":"2020","unstructured":"Tenore G, Nuvoli A, Mohsen A, Cassoni A, Battisti A, Terenzi V, Della Monaca M, Raponi I, Brauner E, De Felice F, Musio D (2020) Tobacco, alcohol and family history of cancer as risk factors of oral squamous cell carcinoma: case-control retrospective study. Appl Sci 10(11):3896","journal-title":"Appl Sci"},{"issue":"12","key":"4859_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2020.101036","volume":"66","author":"DB Nandini","year":"2020","unstructured":"Nandini DB, Rao RS, Hosmani J, Khan S, Patil S, Awan KH (2020) Novel therapies in the management of oral cancer: an update. Dis Mon 66(12):101036","journal-title":"Dis Mon"},{"issue":"1","key":"4859_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11033-024-10144-0","volume":"52","author":"N Agarwal","year":"2025","unstructured":"Agarwal N, Jha AK (2025) DNA hypermethylation of tumor suppressor genes among oral squamous cell carcinoma patients: a prominent diagnostic biomarker. Mol Biol Rep 52(1):44","journal-title":"Mol Biol Rep"},{"issue":"6","key":"4859_CR10","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3390\/biomedicines12061150","volume":"12","author":"C Ionescu","year":"2024","unstructured":"Ionescu C, Kamal FZ, Ciobica A, Halitchi G, Burlui V, Petroaie AD (2024) Oxidative stress in the pathogenesis of oral cancer. Biomedicines 12(6):1150","journal-title":"Biomedicines"},{"issue":"1\u20132","key":"4859_CR11","first-page":"167","volume":"711","author":"D Ziech","year":"2011","unstructured":"Ziech D, Franco R, Pappa A, Panayiotidis MI (2011) Reactive oxygen species (ROS)\u2013\u2013induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res\/Fundam Mol Mech Mutagen 711(1\u20132):167\u2013173","journal-title":"Mutat Res\/Fundam Mol Mech Mutagen"},{"issue":"1","key":"4859_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2174\/1389450116666150113121054","volume":"16","author":"Q Wu","year":"2015","unstructured":"Wu Q, Ni X (2015) ROS-mediated DNA methylation pattern alterations in carcinogenesis. Curr Drug Targets 16(1):13\u201319","journal-title":"Curr Drug Targets"},{"issue":"9","key":"4859_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091358","volume":"10","author":"S Prakash","year":"2021","unstructured":"Prakash S, Radha KM, Kumari N, Thakur M, Rathour S, Pundir A, Sharma AK, Bangar SP, Dhumal S, Singh S (2021) Plant-based antioxidant extracts and compounds in the management of oral cancer. Antioxidants 10(9):1358","journal-title":"Antioxidants"},{"issue":"2","key":"4859_CR14","doi-asserted-by":"publisher","first-page":"438","DOI":"10.4103\/0973-1482.151935","volume":"12","author":"P Katakwar","year":"2016","unstructured":"Katakwar P, Metgud R, Naik S, Mittal R (2016) Oxidative stress marker in oral cancer: a review. J Cancer Res Ther 12(2):438\u2013446","journal-title":"J Cancer Res Ther"},{"issue":"10","key":"4859_CR15","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3390\/antiox10101553","volume":"10","author":"A Bouyahya","year":"2021","unstructured":"Bouyahya A, El Menyiy N, Oumeslakht L, El Allam A, Balahbib A, Rauf A, Muhammad N, Kuznetsova E, Derkho M, Thiruvengadam M, Shariati MA (2021) Preclinical and clinical antioxidant effects of natural compounds against oxidative stress-induced epigenetic instability in tumor cells. Antioxidants 10(10):1553","journal-title":"Antioxidants"},{"issue":"1","key":"4859_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s43682-025-00034-2","volume":"5","author":"R Raina","year":"2025","unstructured":"Raina R, Bhatt R, Hussain A, Afroze N, Hussain A (2025) Polyphenols reverse ROS induced epigenetic alterations in the process of carcinogenesis. Epigenet Commun 5(1):5","journal-title":"Epigenet Commun"},{"issue":"3","key":"4859_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/CCO.0000000000000444","volume":"30","author":"Y Ghantous","year":"2018","unstructured":"Ghantous Y, Schussel JL, Brait M (2018) Tobacco and alcohol-induced epigenetic changes in oral carcinoma. Curr Opin Oncol 30(3):152\u2013158","journal-title":"Curr Opin Oncol"},{"key":"4859_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.958146","volume":"13","author":"P Liu","year":"2022","unstructured":"Liu P, Yang F, Zhang L, Hu Y, Chen B, Wang J, Su L, Wu M, Chen W (2022) Emerging role of different DNA methyltransferases in the pathogenesis of cancer. Front Pharmacol 13:958146","journal-title":"Front Pharmacol"},{"issue":"2","key":"4859_CR19","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4103\/jomfp.JOMFP_150_17","volume":"21","author":"KN Hema","year":"2017","unstructured":"Hema KN, Smitha T, Sheethal HS, Mirnalini SA (2017) Epigenetics in oral squamous cell carcinoma. J Oral Maxillofac Pathol 21(2):252\u2013259","journal-title":"J Oral Maxillofac Pathol"},{"issue":"1","key":"4859_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40364-017-0081-z","volume":"5","author":"W Zhang","year":"2017","unstructured":"Zhang W, Xu J (2017) DNA methyltransferases and their roles in tumorigenesis. Biomark Res 5(1):1","journal-title":"Biomark Res"},{"issue":"11","key":"4859_CR21","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1073\/pnas.1522491113","volume":"113","author":"Q Du","year":"2016","unstructured":"Du Q, Wang Z, Schramm VL (2016) Human DNMT1 transition state structure. Proc Natl Acad Sci USA 113(11):2916\u20132921","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"4859_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrg.2017.80","volume":"19","author":"F Lyko","year":"2018","unstructured":"Lyko F (2018) The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat Rev Genet 19(2):81\u201392","journal-title":"Nat Rev Genet"},{"issue":"1","key":"4859_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0095-0","volume":"4","author":"Y Cheng","year":"2019","unstructured":"Cheng Y, He C, Wang M, Ma X, Mo F, Yang S, Han J, Wei X (2019) Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther 4(1):62","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"4859_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00292-x","volume":"9","author":"CT Viet","year":"2021","unstructured":"Viet CT, Yu G, Asam K, Thomas CM, Yoon AJ, Wongworawat YC, Haghighiabyaneh M, Kilkuts CA, McGue CM, Couey MA, Callahan NF (2021) The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma. Biomark Res 9(1):42","journal-title":"Biomark Res"},{"issue":"2","key":"4859_CR25","doi-asserted-by":"publisher","first-page":"340","DOI":"10.37933\/nipes\/7.2.2025.26","volume":"7","author":"P Tomar","year":"2025","unstructured":"Tomar P, Singh D, Anand A, Verma S, Agarwal N, Mathur R, Pamei S, Gupta VK, Jha AK (2025) Role of histone modifications in oral squamous cell carcinoma. NIPES-J Sci Technol Res 7(2):340\u2013353","journal-title":"NIPES-J Sci Technol Res"},{"key":"4859_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1208\/s12248-013-9548-5","volume":"16","author":"VS Thakur","year":"2014","unstructured":"Thakur VS, Deb G, Babcook MA, Gupta S (2014) Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention. AAPS J 16:151\u2013163","journal-title":"AAPS J"},{"issue":"4","key":"4859_CR27","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/odi.13115","volume":"26","author":"H Yang","year":"2020","unstructured":"Yang H, Jin X, Dan H, Chen Q (2020) Histone modifications in oral squamous cell carcinoma and oral potentially malignant disorders. Oral Dis 26(4):719\u2013732","journal-title":"Oral Dis"},{"issue":"2","key":"4859_CR28","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10528-019-09941-1","volume":"58","author":"J Ga\u017adzicka","year":"2020","unstructured":"Ga\u017adzicka J, Go\u0142\u0105bek K, Strzelczyk JK, Ostrowska Z (2020) Epigenetic modifications in head and neck cancer. Biochem Genet 58(2):213\u2013244","journal-title":"Biochem Genet"},{"issue":"13","key":"4859_CR29","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23356","volume":"9","author":"MK Shanmugam","year":"2017","unstructured":"Shanmugam MK, Arfuso F, Arumugam S, Chinnathambi A, Jinsong B, Warrier S, Wang LZ, Kumar AP, Ahn KS, Sethi G, Lakshmanan M (2017) Role of novel histone modifications in cancer. Oncotarget 9(13):11414","journal-title":"Oncotarget"},{"issue":"12","key":"4859_CR30","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.3390\/cancers12123657","volume":"12","author":"S Kumar","year":"2020","unstructured":"Kumar S, Gonzalez EA, Rameshwar P, Etchegaray JP (2020) Non-coding RNAs as mediators of epigenetic changes in malignancies. Cancers 12(12):3657","journal-title":"Cancers"},{"issue":"4","key":"4859_CR31","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20200032","volume":"65","author":"H Yan","year":"2021","unstructured":"Yan H, Bu P (2021) Non-coding RNA in cancer. Essays Biochem 65(4):625\u2013639","journal-title":"Essays Biochem"},{"issue":"7","key":"4859_CR32","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.3390\/ijms18071506","volume":"18","author":"RM Castilho","year":"2017","unstructured":"Castilho RM, Squarize CH, Almeida LO (2017) Epigenetic modifications and head and neck cancer: implications for tumor progression and resistance to therapy. Int J Mol Sci 18(7):1506","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4859_CR33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.gpb.2015.09.006","volume":"14","author":"Y Fang","year":"2016","unstructured":"Fang Y, Fullwood MJ (2016) Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinform 14(1):42\u201354","journal-title":"Genomics Proteomics Bioinform"},{"key":"4859_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.561833","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wang S, Ren Y, Zhou X (2020) The role of lncRNA crosstalk in leading cancer metastasis of head and neck squamous cell carcinoma. Front Oncol 10:561833","journal-title":"Front Oncol"},{"key":"4859_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154507","volume":"246","author":"R Asemi","year":"2023","unstructured":"Asemi R, Nikoo NR, Asemi Z, Shafabakhsh R, Hajijafari M, Sharifi M, Homayoonfal M, Davoodvandi A, Hakamifard A (2023) Modulation of long non-coding RNAs by resveratrol as a potential therapeutic approach in cancer: a comprehensive review. Pathol Res Pract 246:154507","journal-title":"Pathol Res Pract"},{"key":"4859_CR36","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S241093","author":"X Lu","year":"2020","unstructured":"Lu X, Chen D, Yang F, Xing N (2020) Quercetin inhibits epithelial-to-mesenchymal transition (EMT) process and promotes apoptosis in prostate cancer via downregulating lncRNA MALAT1. Cancer Manag Res. https:\/\/doi.org\/10.2147\/CMAR.S241093","journal-title":"Cancer Manag Res"},{"issue":"1","key":"4859_CR37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12943-023-01749-3","volume":"22","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Zhu Y, Cao X, Tan W, Yu J, Lu Y, Kang R, Wang X, Li E (2023) The epigenetic regulatory mechanism of PIWI\/piRNAs in human cancers. Mol Cancer 22(1):45","journal-title":"Mol Cancer"},{"issue":"2","key":"4859_CR38","first-page":"14","volume":"9","author":"S Dontha","year":"2016","unstructured":"Dontha S (2016) A review on antioxidant methods. Asian J Pharm Clin Res 9(2):14\u201332","journal-title":"Asian J Pharm Clin Res"},{"issue":"3","key":"4859_CR39","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","volume":"94","author":"\u0130 Gulcin","year":"2020","unstructured":"Gulcin \u0130 (2020) Antioxidants and antioxidant methods: an updated overview. Arch Toxicol 94(3):651\u2013715","journal-title":"Arch Toxicol"},{"issue":"1","key":"4859_CR40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s43682-025-00034-2","volume":"5","author":"R Raina","year":"2025","unstructured":"Raina R, Bhatt R, Hussain A, Afroze N, Hussain A (2025) Polyphenols reverse ROS induced epigenetic alterations in the process of carcinogenesis. Epigenetics Commun 5(1):5","journal-title":"Epigenetics Commun"},{"issue":"5","key":"4859_CR41","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1002\/fft2.439","volume":"5","author":"E Sharma","year":"2024","unstructured":"Sharma E, Tewari M, Sati P, Sharma I, Attri DC, Rana S, Aldahish AA, Calina D, Dhyani P, Sharifi-Rad J, Cho WC (2024) Serving up health: how phytochemicals transform food into medicine in the battle against cancer. Food Front 5(5):1866\u20131908","journal-title":"Food Front"},{"key":"4859_CR42","doi-asserted-by":"publisher","first-page":"992","DOI":"10.3389\/fphar.2020.00992","volume":"11","author":"SH Akone","year":"2020","unstructured":"Akone SH, Ntie-Kang F, Stuhldreier F, Ewonkem MB, Noah AM, Mouelle SEM, M\u00fcller R (2020) Natural products impacting DNA methyltransferases and histone deacetylases. Front Pharmacol 11:992","journal-title":"Front Pharmacol"},{"issue":"1","key":"4859_CR43","volume":"2022","author":"S Hou","year":"2022","unstructured":"Hou S (2022) Genistein: therapeutic and preventive effects, mechanisms, and clinical application in digestive tract tumor. Evid\u2010Based Complement Alternative Med 2022(1):5957378","journal-title":"Evid\u2010Based Complement Alternative Med"},{"issue":"1","key":"4859_CR44","doi-asserted-by":"publisher","first-page":"3268136","DOI":"10.1155\/2021\/3268136","volume":"2021","author":"J Sharifi-Rad","year":"2021","unstructured":"Sharifi-Rad J, Quispe C, Imran M, Rauf A, Nadeem M, Gondal TA, Ahmad B, Atif M, Mubarak MS, Sytar O, Zhilina OM (2021) Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits. Oxid Med Cell Longev 2021(1):3268136","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"4859_CR45","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3390\/molecules29061373","volume":"29","author":"WH Talib","year":"2024","unstructured":"Talib WH, Awajan D, Alqudah A, Alsawwaf R, Althunibat R, Abu AlRoos M, Al Safadi A, Abu Asab S, Hadi RW, Al Kury LT (2024) Targeting cancer hallmarks with epigallocatechin gallate (EGCG): mechanistic basis and therapeutic targets. Molecules 29(6):1373","journal-title":"Molecules"},{"issue":"14","key":"4859_CR46","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.3390\/molecules25143146","volume":"25","author":"SA Almatroodi","year":"2020","unstructured":"Almatroodi SA, Almatroudi A, Khan AA, Alhumaydhi FA, Alsahli MA, Rahmani AH (2020) Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer. Molecules 25(14):3146","journal-title":"Molecules"},{"key":"4859_CR47","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.lfs.2018.06.028","volume":"207","author":"M Elshaer","year":"2018","unstructured":"Elshaer M, Chen Y, Wang XJ, Tang X (2018) Resveratrol: an overview of its anti-cancer mechanisms. Life Sci 207:340\u2013349","journal-title":"Life Sci"},{"issue":"12","key":"4859_CR48","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.3390\/ijms18122589","volume":"18","author":"JH Ko","year":"2017","unstructured":"Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Bishayee A, Ahn KS (2017) The role of resveratrol in cancer therapy. Int J Mol Sci 18(12):2589","journal-title":"Int J Mol Sci"},{"issue":"23","key":"4859_CR49","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.3390\/nu14235152","volume":"14","author":"A Kapa\u0142a","year":"2022","unstructured":"Kapa\u0142a A, Szlendak M, Motacka E (2022) The anti-cancer activity of lycopene: a systematic review of human and animal studies. Nutrients 14(23):5152","journal-title":"Nutrients"},{"issue":"13","key":"4859_CR50","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.3390\/molecules26133888","volume":"26","author":"BP Puah","year":"2021","unstructured":"Puah BP, Jalil J, Attiq A, Kamisah Y (2021) New insights into molecular mechanism behind anti-cancer activities of lycopene. Molecules 26(13):3888","journal-title":"Molecules"},{"issue":"11","key":"4859_CR51","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1002\/ptr.6155","volume":"32","author":"A Rauf","year":"2018","unstructured":"Rauf A, Imran M, Khan IA, ur\u2010Rehman M, Gilani SA, Mehmood Z, Mubarak MS (2018) Anticancer potential of quercetin: a comprehensive review. Phytother Res 32(11):2109\u20132130","journal-title":"Phytother Res"},{"issue":"1","key":"4859_CR52","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12935-022-02677-w","volume":"22","author":"P Asgharian","year":"2022","unstructured":"Asgharian P, Tazekand AP, Hosseini K, Forouhandeh H, Ghasemnejad T, Ranjbar M, Hasan M, Kumar M, Beirami SM, Tarhriz V, Soofiyani SR (2022) Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets. Cancer Cell Int 22(1):257","journal-title":"Cancer Cell Int"},{"key":"4859_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.820969","volume":"13","author":"YX Goh","year":"2022","unstructured":"Goh YX, Jalil J, Lam KW, Husain K, Premakumar CM (2022) Genistein: a review on its anti-inflammatory properties. Front Pharmacol 13:820969","journal-title":"Front Pharmacol"},{"key":"4859_CR54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.biopha.2015.10.026","volume":"76","author":"AA Ganai","year":"2015","unstructured":"Ganai AA, Farooqi H (2015) Bioactivity of genistein: a review of in vitro and in vivo studies. Biomed Pharmacother 76:30\u201338","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4859_CR55","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1080\/10942912.2023.2281257","volume":"26","author":"H Naeem","year":"2023","unstructured":"Naeem H, Momal U, Imran M, Shahbaz M, Hussain M, Alsagaby SA, Al Abdulmonem W, Umar M, Mujtaba A, El-Ghorab AH, Ghoneim MM (2023) Anticancer perspectives of genistein: a comprehensive review. Int J Food Prop 26(2):3305\u20133341","journal-title":"Int J Food Prop"},{"issue":"4","key":"4859_CR56","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1124\/pr.115.010843","volume":"68","author":"BM Dietz","year":"2016","unstructured":"Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL (2016) Botanicals and their bioactive phytochemicals for women\u2019s health. Pharmacol Rev 68(4):1026\u20131073","journal-title":"Pharmacol Rev"},{"issue":"5","key":"4859_CR57","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/gcc.22154","volume":"53","author":"Q Xie","year":"2014","unstructured":"Xie Q, Bai Q, Zou LY, Zhang QY, Zhou Y, Chang H, Yi L, Zhu JD, Mi MT (2014) Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. Genes Chromosomes Cancer 53(5):422\u2013431","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"4859_CR58","doi-asserted-by":"publisher","first-page":"350","DOI":"10.2174\/138955712799829258","volume":"12","author":"HQ Li","year":"2012","unstructured":"Li HQ, Luo Y, Qiao CH (2012) The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone. Mini Rev Med Chem 12(4):350\u2013362","journal-title":"Mini Rev Med Chem"},{"issue":"1","key":"4859_CR59","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/em.20363","volume":"49","author":"A King-Batoon","year":"2008","unstructured":"King-Batoon A, Leszczynska JM, Klein CB (2008) Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ Mol Mutagen 49(1):36\u201345","journal-title":"Environ Mol Mutagen"},{"issue":"5","key":"4859_CR60","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/omi.2011.0105","volume":"16","author":"R Bosviel","year":"2012","unstructured":"Bosviel R, Dumollard E, D\u00e9chelotte P, Bignon YJ, Bernard-Gallon D (2012) Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? OMICS 16(5):235\u2013244","journal-title":"OMICS"},{"issue":"6","key":"4859_CR61","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1258\/ebm.2011.010347","volume":"236","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Chen H (2011) Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line. Exp Biol Med (Maywood) 236(6):714\u2013722","journal-title":"Exp Biol Med (Maywood)"},{"issue":"4","key":"4859_CR62","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/carcin\/bgp042","volume":"30","author":"S Majid","year":"2009","unstructured":"Majid S, Dar AA, Ahmad AE, Hirata H, Kawakami K, Shahryari V, Saini S, Tanaka Y, Dahiya AV, Khatri G, Dahiya R (2009) BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30(4):662\u2013670","journal-title":"Carcinogenesis"},{"issue":"1","key":"4859_CR63","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s43046-022-00140-5","volume":"34","author":"AM Hussein","year":"2022","unstructured":"Hussein AM, Attaai AH, Zahran AM (2022) Genistein anticancer efficacy during induced oral squamous cell carcinoma: an experimental study. J Egypt Natl Cancer Inst 34(1):37","journal-title":"J Egypt Natl Cancer Inst"},{"key":"4859_CR64","doi-asserted-by":"crossref","unstructured":"Ravindranath MH, Muthugounder S, Presser N, Viswanathan S (2004) Anticancer therapeutic potential of soy isoflavone, genistein.\u00a0Complementary and alternative approaches to biomedicine, pp.121\u2013165","DOI":"10.1007\/978-1-4757-4820-8_11"},{"issue":"3","key":"4859_CR65","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/ecam\/nen011","volume":"7","author":"TL Johnson","year":"2010","unstructured":"Johnson TL, Lai MB, Lai JC, Bhushan A (2010) Inhibition of cell proliferation and MAP kinase and Akt pathways in oral squamous cell carcinoma by genistein and biochanin A. Evid Based Complement Alternat Med 7(3):351\u2013358","journal-title":"Evid Based Complement Alternat Med"},{"key":"4859_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01336","volume":"10","author":"HS Tuli","year":"2019","unstructured":"Tuli HS, Tuorkey MJ, Thakral F, Sak K, Kumar M, Sharma AK, Sharma U, Jain A, Aggarwal V, Bishayee A (2019) Molecular mechanisms of action of genistein in cancer: recent advances. Front Pharmacol 10:1336. https:\/\/doi.org\/10.3389\/fphar.2019.01336","journal-title":"Front Pharmacol"},{"issue":"8","key":"4859_CR67","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/13543776.2016.1203419","volume":"26","author":"L Chakrawarti","year":"2016","unstructured":"Chakrawarti L, Agrawal R, Dang S, Gupta S, Gabrani R (2016) Therapeutic effects of EGCG: a patent review. Expert Opin Ther Pat 26(8):907\u2013916","journal-title":"Expert Opin Ther Pat"},{"issue":"12","key":"4859_CR68","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","volume":"82","author":"BN Singh","year":"2011","unstructured":"Singh BN, Shankar S, Srivastava RK (2011) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82(12):1807\u20131821","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"4859_CR69","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1080\/10408398.2016.1231168","volume":"58","author":"RY Gan","year":"2018","unstructured":"Gan RY, Li HB, Sui ZQ, Corke H (2018) Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): an updated review. Crit Rev Food Sci Nutr 58(6):924\u2013941","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"3","key":"4859_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030654","volume":"30","author":"L Capasso","year":"2025","unstructured":"Capasso L, De Masi L, Sirignano C, Maresca V, Basile A, Nebbioso A, Rigano D, Bontempo P (2025) Epigallocatechin gallate (EGCG): pharmacological properties, biological activities and therapeutic potential. Molecules 30(3):654","journal-title":"Molecules"},{"key":"4859_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.arres.2023.100085","volume":"9","author":"A Sehgal","year":"2023","unstructured":"Sehgal A, Bhat MA, Dogra D, Rawat S, Dhatwalia SK (2023) EGCG: the antioxidant powerhouse in lung cancer management and chemotherapy enhancement. Adv Redox Res 9:100085","journal-title":"Adv Redox Res"},{"issue":"4","key":"4859_CR72","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.3892\/or.2015.3802","volume":"33","author":"MA Khan","year":"2015","unstructured":"Khan MA, Hussain A, Sundaram MK, Alalami U, Gunasekera D, Ramesh L, Hamza A, Quraishi U (2015) (\u2212)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol Rep 33(4):1976\u20131984","journal-title":"Oncol Rep"},{"issue":"4","key":"4859_CR73","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/carcin\/bgq285","volume":"32","author":"V Nandakumar","year":"2011","unstructured":"Nandakumar V, Vaid M, Katiyar SK (2011) (\u2212)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1\/p21 and p 16 INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32(4):537\u2013544","journal-title":"Carcinogenesis"},{"issue":"7","key":"4859_CR74","doi-asserted-by":"publisher","first-page":"714","DOI":"10.2174\/1568026615666150825125857","volume":"16","author":"E Kim","year":"2016","unstructured":"Kim E, H Bisson W, V Lohr C, E Williams D, Ho E, H Dashwood R, Rajendran P (2016) Histone and non-histone targets of dietary deacetylase inhibitors. Curr Top Med Chem 16(7):714\u2013731","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"4859_CR75","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12935-023-03081-8","volume":"23","author":"C Wang","year":"2023","unstructured":"Wang C, Bai M, Sun Z, Yao N, Zhang A, Guo S, Asemi Z (2023) Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs. Cancer Cell Int 23(1):241","journal-title":"Cancer Cell Int"},{"issue":"5","key":"4859_CR76","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.3390\/molecules28052151","volume":"28","author":"JW Oh","year":"2023","unstructured":"Oh JW, Muthu M, Pushparaj SSC, Gopal J (2023) Anticancer therapeutic effects of green tea catechins (GTCs) when integrated with antioxidant natural components. Molecules 28(5):2151","journal-title":"Molecules"},{"issue":"11","key":"4859_CR77","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.3390\/ijms23116075","volume":"23","author":"E Ferrari","year":"2022","unstructured":"Ferrari E, Bettuzzi S, Naponelli V (2022) The potential of epigallocatechin gallate (EGCG) in targeting autophagy for cancer treatment: a narrative review. Int J Mol Sci 23(11):6075","journal-title":"Int J Mol Sci"},{"issue":"8","key":"4859_CR78","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/pathogens13080634","volume":"13","author":"Y Li","year":"2024","unstructured":"Li Y, Cheng L, Li M (2024) Effects of green tea extract epigallocatechin-3-gallate on oral diseases: a narrative review. Pathogens 13(8):634","journal-title":"Pathogens"},{"issue":"2","key":"4859_CR79","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.canlet.2015.02.034","volume":"360","author":"JC Lee","year":"2015","unstructured":"Lee JC, Chung LC, Chen YJ, Feng TH, Chen WT, Juang HH (2015) Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett 360(2):310\u2013318","journal-title":"Cancer Lett"},{"issue":"1","key":"4859_CR80","first-page":"352371","volume":"2014","author":"Y Yang","year":"2014","unstructured":"Yang Y, Kim SC, Yu T, Yi YS, Rhee MH, Sung GH, Yoo BC, Cho JY (2014) Functional roles of p38 mitogen\u2010activated protein kinase in macrophage\u2010mediated inflammatory responses. Mediators Inflamm 2014(1):352371","journal-title":"Mediators Inflamm"},{"issue":"22","key":"4859_CR81","doi-asserted-by":"publisher","first-page":"3172","DOI":"10.1038\/sj.onc.1210410","volume":"26","author":"AJ Whitmarsh","year":"2007","unstructured":"Whitmarsh AJ, Davis RJ (2007) Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 26(22):3172\u20133184","journal-title":"Oncogene"},{"issue":"9\u201310","key":"4859_CR82","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1177\/1947601913507951","volume":"4","author":"HK Koul","year":"2013","unstructured":"Koul HK, Pal M, Koul S (2013) Role of p38 MAP kinase signal transduction in solid tumors. Genes Cancer 4(9\u201310):342\u2013359","journal-title":"Genes Cancer"},{"issue":"3","key":"4859_CR83","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/ijms23031108","volume":"23","author":"LJW Pua","year":"2022","unstructured":"Pua LJW, Mai CW, Chung FFL, Khoo ASB, Leong CO, Lim WM, Hii LW (2022) Role of JNK and p38 MAPK signaling in nasopharyngeal carcinoma. Int J Mol Sci 23(3):1108","journal-title":"Int J Mol Sci"},{"key":"4859_CR84","doi-asserted-by":"crossref","unstructured":"Irimie AI, Braicu C, Zanoaga O, Pileczki V, Gherman C, Berindan-Neagoe I, Campian RS (2015) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells.\u00a0OncoTargets and therapy, pp.461\u2013470","DOI":"10.2147\/OTT.S78358"},{"issue":"6","key":"4859_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062084","volume":"21","author":"A Shaito","year":"2020","unstructured":"Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah GK, Pintus G (2020) Potential adverse effects of resveratrol: a literature review. Int J Mol Sci 21(6):2084","journal-title":"Int J Mol Sci"},{"issue":"3","key":"4859_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030536","volume":"30","author":"A Jaa","year":"2025","unstructured":"Jaa A, de Moura PHB, Ruiz-Larrea MB, Ruiz Sanz JI, Richard T (2025) Potential transformation of food resveratrol: mechanisms and biological impact. Molecules 30(3):536","journal-title":"Molecules"},{"issue":"12","key":"4859_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122589","volume":"18","author":"JH Ko","year":"2017","unstructured":"Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Bishayee A, Ahn KS (2017) The role of resveratrol in cancer therapy. Int J Mol Sci 18(12):2589","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4859_CR88","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-017-0038-6","volume":"1","author":"AY Berman","year":"2017","unstructured":"Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol 1(1):35","journal-title":"NPJ Precis Oncol"},{"issue":"1","key":"4859_CR89","doi-asserted-by":"publisher","DOI":"10.3390\/medicines6010024","volume":"6","author":"M Farhan","year":"2019","unstructured":"Farhan M, Ullah MF, Faisal M, Farooqi AA, Sabitaliyevich UY, Biersack B, Ahmad A (2019) Differential methylation and acetylation as the epigenetic basis of resveratrol\u2019s anticancer activity. Medicines 6(1):24","journal-title":"Medicines"},{"issue":"5","key":"4859_CR90","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/biof.1544","volume":"45","author":"B Chatterjee","year":"2019","unstructured":"Chatterjee B, Ghosh K, Kanade SR (2019) Resveratrol modulates epigenetic regulators of promoter histone methylation and acetylation that restores BRCA1, p53, p21CIP1 in human breast cancer cell lines. BioFactors 45(5):818\u2013829","journal-title":"BioFactors"},{"issue":"1","key":"4859_CR91","volume":"17","author":"A Keshavarzmotamed","year":"2024","unstructured":"Keshavarzmotamed A, Mousavi V, Masihipour N, Rahmati A, Dehmordi RM, Ghezelbash B, Alimohammadi M, Mafi A (2024) Regulating miRNAs expression by resveratrol: novel insights based on molecular mechanism and strategies for cancer therapy. Curr Mol Pharmacol 17(1):E18761429249717","journal-title":"Curr Mol Pharmacol"},{"issue":"1","key":"4859_CR92","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/pharmaceutics15010275","volume":"15","author":"G Angellotti","year":"2023","unstructured":"Angellotti G, Di Prima G, Belfiore E, Campisi G, De Caro V (2023) Chemopreventive and anticancer role of resveratrol against oral squamous cell carcinoma. Pharmaceutics 15(1):275","journal-title":"Pharmaceutics"},{"key":"4859_CR93","doi-asserted-by":"publisher","first-page":"1246873","DOI":"10.3389\/froh.2023.1246873","volume":"4","author":"M Kumar","year":"2023","unstructured":"Kumar M, Jha AK (2023) Exploring the potential of dietary factors and plant extracts as chemopreventive agents in oral squamous cell carcinoma treatment. Front Oral Health 4:1246873","journal-title":"Front Oral Health"},{"issue":"3","key":"4859_CR94","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3892\/ijo.2017.3866","volume":"50","author":"CH Chang","year":"2017","unstructured":"Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM, Tsao JW, Juan YN, Chiu HY, Yang JS, Wang CC (2017) Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: a key role of AMPK and Akt\/mTOR signaling. Int J Oncol 50(3):873\u2013882","journal-title":"Int J Oncol"},{"issue":"11","key":"4859_CR95","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1080\/10408398.2013.801827","volume":"56","author":"L M\u00fcller","year":"2016","unstructured":"M\u00fcller L, Caris-Veyrat C, Lowe G, B\u00f6hm V (2016) Lycopene and its antioxidant role in the prevention of cardiovascular diseases\u2014a critical review. Crit Rev Food Sci Nutr 56(11):1868\u20131879","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"8","key":"4859_CR96","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/antiox9080706","volume":"9","author":"M Imran","year":"2020","unstructured":"Imran M, Ghorat F, Ul-Haq I, Ur-Rehman H, Aslam F, Heydari M, Shariati MA, Okuskhanova E, Yessimbekov Z, Thiruvengadam M, Hashempur MH (2020) Lycopene as a natural antioxidant used to prevent human health disorders. Antioxidants 9(8):706","journal-title":"Antioxidants"},{"issue":"3","key":"4859_CR97","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4274\/tjps.43043","volume":"14","author":"M Bacanli","year":"2017","unstructured":"Bacanli M, Ba\u015faran N, Ba\u015faran AA (2017) Lycopene: is it beneficial to human health as an antioxidant? Turk J Pharm Sci 14(3):311","journal-title":"Turk J Pharm Sci"},{"key":"4859_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109323","volume":"127","author":"M Caseiro","year":"2020","unstructured":"Caseiro M, Ascenso A, Costa A, Creagh-Flynn J, Johnson M, Sim\u00f5es S (2020) Lycopene in human health. LWT 127:109323","journal-title":"LWT"},{"issue":"8","key":"4859_CR99","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3109\/10715762.2011.564168","volume":"45","author":"M Kelkel","year":"2011","unstructured":"Kelkel M, Schumacher M, Dicato M, Diederich M (2011) Antioxidant and anti-proliferative properties of lycopene. Free Radic Res 45(8):925\u2013940","journal-title":"Free Radic Res"},{"issue":"1","key":"4859_CR100","volume":"2013","author":"C Trejo-Sol\u00eds","year":"2013","unstructured":"Trejo-Sol\u00eds C, Pedraza-Chaverr\u00ed J, Torres-Ramos M, Jim\u00e9nez-Farf\u00e1n D, Cruz Salgado A, Serrano-Garc\u00eda N, Osorio-Rico L, Sotelo J (2013) Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid Based Complement Alternat Med 2013(1):705121","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"4859_CR101","volume":"2014","author":"LJ Fu","year":"2014","unstructured":"Fu LJ, Ding YB, Wu LX, Wen CJ, Qu Q, Zhang X, Zhou HH (2014) The effects of lycopene on the methylation of the GSTP1 promoter and global methylation in prostatic cancer cell lines PC3 and LNCaP. Int J Endocrinol 2014(1):620165","journal-title":"Int J Endocrinol"},{"issue":"3","key":"4859_CR102","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.3892\/mmr.2016.4841","volume":"13","author":"D Li","year":"2016","unstructured":"Li D, Chen L, Zhao W, Hao J, An R (2016) MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer. Mol Med Rep 13(3):2708\u20132714","journal-title":"Mol Med Rep"},{"key":"4859_CR103","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S283927","author":"A Tao","year":"2021","unstructured":"Tao A, Wang X, Li C (2021) Effect of lycopene on oral squamous cell carcinoma cell growth by inhibiting IGF1 pathway. Cancer Manag Res. https:\/\/doi.org\/10.2147\/CMAR.S283927","journal-title":"Cancer Manag Res"},{"key":"4859_CR104","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S251614","author":"R Wang","year":"2020","unstructured":"Wang R, Lu X, Yu R (2020) Lycopene inhibits epithelial\u2013mesenchymal transition and promotes apoptosis in oral cancer via PI3K\/AKT\/m-TOR signal pathway. Drug Des Devel Ther. https:\/\/doi.org\/10.2147\/DDDT.S251614","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"4859_CR105","volume":"2020","author":"D Yang","year":"2020","unstructured":"Yang D, Wang T, Long M, Li P (2020) Quercetin: its main pharmacological activity and potential application in clinical medicine. Oxid Med Cell Longev 2020(1):8825387","journal-title":"Oxid Med Cell Longev"},{"key":"4859_CR106","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.plaphy.2021.05.023","volume":"166","author":"P Singh","year":"2021","unstructured":"Singh P, Arif Y, Bajguz A, Hayat S (2021) The role of quercetin in plants. Plant Physiol Biochem 166:10\u201319","journal-title":"Plant Physiol Biochem"},{"key":"4859_CR107","unstructured":"Bentz AB (2017) A Review of quercetin: chemistry, antioxident properties, and bioavailability.\u00a0J Young Investigators"},{"issue":"5","key":"4859_CR108","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051315","volume":"26","author":"SA Almatroodi","year":"2021","unstructured":"Almatroodi SA, Alsahli MA, Almatroudi A, Verma AK, Aloliqi A, Allemailem KS, Khan AA, Rahmani AH (2021) Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules 26(5):1315","journal-title":"Molecules"},{"issue":"19","key":"4859_CR109","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.3390\/molecules27196545","volume":"27","author":"W Qi","year":"2022","unstructured":"Qi W, Qi W, Xiong D, Long M (2022) Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy. Molecules 27(19):6545","journal-title":"Molecules"},{"issue":"19","key":"4859_CR110","doi-asserted-by":"publisher","first-page":"11746","DOI":"10.3390\/ijms231911746","volume":"23","author":"P Biswas","year":"2022","unstructured":"Biswas P, Dey D, Biswas PK, Rahaman TI, Saha S, Parvez A, Khan DA, Lily NJ, Saha K, Sohel M, Hasan MM (2022) A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells. Int J Mol Sci 23(19):11746","journal-title":"Int J Mol Sci"},{"key":"4859_CR111","doi-asserted-by":"crossref","unstructured":"Russo GL, Ungaro P (2019) Epigenetic mechanisms of quercetin and other flavonoids in cancer therapy and prevention. In\u00a0Epigenetics of cancer prevention\u00a0(pp. 187\u2013202). Academic Press","DOI":"10.1016\/B978-0-12-812494-9.00009-3"},{"issue":"1","key":"4859_CR112","doi-asserted-by":"publisher","first-page":"283","DOI":"10.31557\/APJCP.2023.24.1.283","volume":"24","author":"HK Son","year":"2023","unstructured":"Son HK, Kim D (2023) Quercetin induces cell cycle arrest and apoptosis in YD10B and YD38 oral squamous cell carcinoma cells. Asian Pacific J Cancer Prev: APJCP 24(1):283","journal-title":"Asian Pacific J Cancer Prev: APJCP"},{"issue":"2","key":"4859_CR113","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1515\/tjb-2023-0003","volume":"49","author":"N Li","year":"2024","unstructured":"Li N, Wang J (2024) Quercetin induces cytotoxicity and apoptosis, reduces metastasis and drug resistance in oral cancer cells. Turk J Biochem 49(2):148\u2013156","journal-title":"Turk J Biochem"},{"issue":"1","key":"4859_CR114","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12935-025-03694-1","volume":"25","author":"MJ Saadh","year":"2025","unstructured":"Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, Mishra A, Taher WM, Alwan M, Jawad MJ, Al-Nuaimi AMA, Alsaikhan F (2025) Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int 25(1):66","journal-title":"Cancer Cell Int"},{"issue":"2","key":"4859_CR115","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jphs.2019.03.005","volume":"140","author":"C Zhang","year":"2019","unstructured":"Zhang C, Hao Y, Sun Y, Liu P (2019) Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22\/WNT1\/\u03b2-catenin axis. J Pharmacol Sci 140(2):128\u2013136","journal-title":"J Pharmacol Sci"},{"issue":"5","key":"4859_CR116","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.phymed.2016.02.011","volume":"23","author":"SH Baek","year":"2016","unstructured":"Baek SH, Ko JH, Lee H, Jung J, Kong M, Lee JW, Lee J, Chinnathambi A, Zayed ME, Alharbi SA, Lee SG, Shim BS, Sethi G, Kim SH, Yang WM, Um JY, Ahn KS (2016) Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine 23(5):566\u2013577. https:\/\/doi.org\/10.1016\/j.phymed.2016.02.011. (Epub 2016 Feb 27 PMID: 27064016)","journal-title":"Phytomedicine"},{"issue":"1","key":"4859_CR117","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/01635581.2018.1397708","volume":"70","author":"SE Kim","year":"2017","unstructured":"Kim SE, Shin SH, Lee JY, Kim CH, Chung IK, Kang HM, Kim IR (2017) Resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells. Nutr Cancer 70(1):125\u2013135. https:\/\/doi.org\/10.1080\/01635581.2018.1397708","journal-title":"Nutr Cancer"},{"key":"4859_CR118","doi-asserted-by":"publisher","first-page":"112164","DOI":"10.1016\/j.biopha.2021.112164","volume":"143","author":"L-X Zhang","year":"2021","unstructured":"Zhang L-X, Li C-X, Kakar MU, Khan MS, Pei-Feng Wu, Amir RM, Dai D-F, Naveed M, Li Q-Y, Saeed M, Shen J-Q, Rajput SA, Li J-H (2021) Resveratrol (RV): a pharmacological review and call for further research. Biomed Pharmacother 143:112164","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4859_CR119","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12903-024-04045-8","volume":"24","author":"MK Alam","year":"2024","unstructured":"Alam MK, Alqhtani NR, Alnufaiy B, Alqahtani AS, Elsahn NA, Russo D, Di Blasio M, Cicci\u00f9 M, Minervini G (2024) A systematic review and meta-analysis of the impact of resveratrol on oral cancer: potential therapeutic implications. BMC Oral Health 24(1):412. https:\/\/doi.org\/10.1186\/s12903-024-04045-8. (PMID:38575921;PMCID:PMC10993553)","journal-title":"BMC Oral Health"},{"key":"4859_CR120","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.06.012","author":"Y Zhang","year":"2025","unstructured":"Zhang Y et al (2025) Molecular targets of resveratrol in oral cancer. Cancer Lett. https:\/\/doi.org\/10.1016\/j.canlet.2024.06.012","journal-title":"Cancer Lett"},{"issue":"7","key":"4859_CR122","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1158\/1535-7163.MCT-19-0873","volume":"19","author":"R Chen","year":"2020","unstructured":"Chen R et al (2020) EGCG synergizes with chemotherapy to overcome resistance in OSCC. Mol Cancer Ther 19(7):1472\u20131484. https:\/\/doi.org\/10.1158\/1535-7163.MCT-19-0873","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"4859_CR123","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.3892\/mmr.2019.10331","volume":"20","author":"H Yoshimura","year":"2019","unstructured":"Yoshimura H, Yoshida H, Matsuda S, Ryoke T, Ohta K, Ohmori M, Yamamoto S, Kiyoshima T, Kobayashi M, Sano K (2019) The therapeutic potential of epigallocatechin-3-gallate against human oral squamous cell carcinoma through inhibition of cell proliferation and induction of apoptosis: In\u00a0vitro and in\u00a0vivo murine xenograft study. Mol Med Rep. 20(2):1139\u20131148. https:\/\/doi.org\/10.3892\/mmr.2019.10331. (PMID: 31173211; PMCID: PMC6625387)","journal-title":"Mol Med Rep."},{"issue":"1","key":"4859_CR124","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nano.2016.08.005","volume":"13","author":"F Ardito","year":"2017","unstructured":"Ardito F et al (2017) Nanoformulated genistein in oral cancer therapy. Nanomedicine 13(1):13\u201328. https:\/\/doi.org\/10.1016\/j.nano.2016.08.005","journal-title":"Nanomedicine"},{"issue":"1","key":"4859_CR125","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s43556-024-00240-9","volume":"5","author":"M Alam","year":"2024","unstructured":"Alam M, Gulzar M, Akhtar MS, Rashid S, Zulfareen T, Shamsi A, Hassan MI (2024) Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies. Mol Biomed 5(1):73. https:\/\/doi.org\/10.1186\/s43556-024-00240-9. (PMID: 39725830; PMCID: PMC11671467)","journal-title":"Mol Biomed"},{"key":"4859_CR126","doi-asserted-by":"publisher","first-page":"5405","DOI":"10.2147\/OTT.S133632","volume":"10","author":"F Ardito","year":"2017","unstructured":"Ardito F, Pellegrino MR, Perrone D, Troiano G, Cocco A, Lo Muzio L (2017) In vitro study on anti-cancer properties of genistein in tongue cancer. Onco Targets Ther 10:5405\u20135415. https:\/\/doi.org\/10.2147\/OTT.S133632","journal-title":"Onco Targets Ther"},{"key":"4859_CR127","doi-asserted-by":"publisher","first-page":"153386","DOI":"10.1016\/j.phymed.2020.153386","volume":"80","author":"A Dev","year":"2021","unstructured":"Dev A, Sarwala MN, Kushwaha AC, Karmakar S, Choudhury SR (2021) Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway. Phytomedicine 80:153386. https:\/\/doi.org\/10.1016\/j.phymed.2020.153386. (ISSN 0944-7113)","journal-title":"Phytomedicine"},{"issue":"23","key":"4859_CR128","doi-asserted-by":"publisher","first-page":"5600","DOI":"10.3390\/cancers15235600","volume":"15","author":"H Mesgari","year":"2023","unstructured":"Mesgari H, Esmaelian S, Nasiri K, Ghasemzadeh S, Doroudgar P, Payandeh Z (2023) Epigenetic regulation in oral squamous cell carcinoma microenvironment: a comprehensive review. Cancers (Basel) 15(23):5600. https:\/\/doi.org\/10.3390\/cancers15235600. (PMID:38067304;PMCID:PMC10705512)","journal-title":"Cancers (Basel)"},{"issue":"2","key":"4859_CR129","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s11095-021-03126-w","volume":"39","author":"M Hussein","year":"2022","unstructured":"Hussein M et al (2022) Challenges in genistein delivery for OSCC therapy. Pharm Res 39(2):486\u2013499. https:\/\/doi.org\/10.1007\/s11095-021-03126-w","journal-title":"Pharm Res"},{"key":"4859_CR130","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s43046-022-00140-5","volume":"34","author":"AM Hussein","year":"2022","unstructured":"Hussein AM, Attaai AH, Zahran AM (2022) Genistein anticancer efficacy during induced oral squamous cell carcinoma: an experimental study. J Egypt Natl Canc Inst 34:37. https:\/\/doi.org\/10.1186\/s43046-022-00140-5","journal-title":"J Egypt Natl Canc Inst"},{"issue":"14","key":"4859_CR131","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.2147\/DDDT.S251614","volume":"24","author":"R Wang","year":"2020","unstructured":"Wang R, Lu X, Yu R (2020) Lycopene inhibits epithelial-mesenchymal transition and promotes apoptosis in Oral Cancer via PI3K\/AKT\/m-TOR signal pathway. Drug Des Devel Ther 24(14):2461\u20132471. https:\/\/doi.org\/10.2147\/DDDT.S251614. (PMID:32606612;PMCID:PMC7321693)","journal-title":"Drug Des Devel Ther"},{"issue":"13","key":"4859_CR132","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2147\/CMAR.S283927","volume":"26","author":"A Tao","year":"2021","unstructured":"Tao A, Wang X, Li C (2021) Effect of lycopene on oral squamous cell carcinoma cell growth by inhibiting IGF1 pathway. Cancer Manag Res 26(13):723\u2013732. https:\/\/doi.org\/10.2147\/CMAR.S283927. (PMID:33531840;PMCID:PMC7847369)","journal-title":"Cancer Manag Res"},{"issue":"3","key":"4859_CR133","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/molecules25030757.PMID:32050534;PMCID:PMC7037689","volume":"25","author":"SR Kim","year":"2020","unstructured":"Kim SR, Lee EY, Kim DJ, Kim HJ, Park HR (2020) Quercetin inhibits cell survival and metastatic ability via the EMT-mediated pathway in oral squamous cell carcinoma. Molecules 25(3):757. https:\/\/doi.org\/10.3390\/molecules25030757.PMID:32050534;PMCID:PMC7037689","journal-title":"Molecules"},{"issue":"2","key":"4859_CR134","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1515\/tjb-2023-0003","volume":"49","author":"N Li","year":"2024","unstructured":"Li N, Wang J (2024) Quercetin induces cytotoxicity and apoptosis, reduces metastasis and drug resistance in oral cancer cells. Turk J Biochem 49(2):148\u2013156. https:\/\/doi.org\/10.1515\/tjb-2023-0003","journal-title":"Turk J Biochem"},{"issue":"2","key":"4859_CR135","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jphs.2019.03.005","volume":"140","author":"C Zhang","year":"2019","unstructured":"Zhang C, Hao Y, Sun Y, Liu P (2019) Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22\/WNT1\/\u03b2-catenin axis. J Pharmacol Sci 140(2):128\u2013136. https:\/\/doi.org\/10.1016\/j.jphs.2019.03.005. (Epub 2019 May 4 PMID: 31257059)","journal-title":"J Pharmacol Sci"},{"issue":"1","key":"4859_CR136","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12935-025-03694-1","volume":"25","author":"MJ Saadh","year":"2025","unstructured":"Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, Mishra A, Taher WM, Alwan M, Jawad MJ, Al-Nuaimi AMA, Alsaikhan F, Farhood B, Akhavan-Sigari R (2025) Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int 25(1):66. https:\/\/doi.org\/10.1186\/s12935-025-03694-1. (PMID:39994659;PMCID:PMC11854426)","journal-title":"Cancer Cell Int"},{"issue":"1","key":"4859_CR137","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1055\/s-0044-1789016","volume":"19","author":"D Afriza","year":"2025","unstructured":"Afriza D, Arma U, Faslah R, Suriyah WH (2025) Anticancer potential of quercetin on oral squamous cell carcinoma: a scoping review and molecular docking. Eur J Dent. 19(1):15\u201323. https:\/\/doi.org\/10.1055\/s-0044-1789016. (Epub 2024 Sep 30. PMID: 39348855; PMCID: PMC11750326)","journal-title":"Eur J Dent."},{"issue":"4","key":"4859_CR138","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.3892\/ol.2015.3598","volume":"10","author":"D Droguett","year":"2015","unstructured":"Droguett D, Castillo C, Leiva E, Theoduloz C, Schmeda-Hirschmann G, Kemmerling U (2015) Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma. Oncol Lett 10(4):2432\u20132438. https:\/\/doi.org\/10.3892\/ol.2015.3598. (Epub 2015 Aug 12. PMID: 26622865; PMCID: PMC4580003)","journal-title":"Oncol Lett"},{"issue":"5","key":"4859_CR139","doi-asserted-by":"publisher","first-page":"521","DOI":"10.5005\/jp-journals-10024-2823","volume":"21","author":"MC Neetha","year":"2020","unstructured":"Neetha MC, Panchaksharappa MG, Pattabhiramasastry S, Shivaprasad NV, Venkatesh UG (2020) Chemopreventive synergism between green tea extract and curcumin in patients with potentially Malignant Oral Disorders: a double-blind, randomized preliminary study. J Contemp Dent Pract 21(5):521\u2013531 (PMID: 32690834)","journal-title":"J Contemp Dent Pract"},{"issue":"11","key":"4859_CR140","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1158\/1940-6207.CAPR-09-0121","volume":"2","author":"AS Tsao","year":"2009","unstructured":"Tsao AS, Liu D, Martin J, Tang XM, Lee JJ, El-Naggar AK, Wistuba I, Culotta KS, Mao L, Gillenwater A, Sagesaka YM, Hong WK, Papadimitrakopoulou V (2009) Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res (Phila) 2(11):931\u2013941. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-09-0121. (PMID:19892663;PMCID:PMC4243312)","journal-title":"Cancer Prev Res (Phila)"},{"key":"4859_CR141","doi-asserted-by":"publisher","unstructured":"Berman AY, Motechin RA, Wiesenfeld MY et al. (2017) The therapeutic potential of resveratrol: a review of clinical trials. npj Precision Onc. https:\/\/doi.org\/10.1038\/s41698-017-0038-6","DOI":"10.1038\/s41698-017-0038-6"},{"key":"4859_CR142","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12935-019-0906-y","volume":"19","author":"M Honari","year":"2019","unstructured":"Honari M, Shafabakhsh R, Reiter RJ et al (2019) Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms. Cancer Cell Int 19:180. https:\/\/doi.org\/10.1186\/s12935-019-0906-y","journal-title":"Cancer Cell Int"},{"issue":"3","key":"4859_CR143","doi-asserted-by":"publisher","first-page":"e1353","DOI":"10.1002\/cnr2.1353","volume":"4","author":"M Annaji","year":"2021","unstructured":"Annaji M, Poudel I, Boddu SHS, Arnold RD, Tiwari AK, Babu RJ (2021) Resveratrol-loaded nanomedicines for cancer applications. Cancer Rep (Hoboken) 4(3):e1353. https:\/\/doi.org\/10.1002\/cnr2.1353. (Epub 2021 Mar 2. PMID: 33655717; PMCID: PMC8222557)","journal-title":"Cancer Rep (Hoboken)"},{"key":"4859_CR144","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2174206","author":"C Li","year":"2023","unstructured":"Li C, Wang Z, Lei H, Zhang D (2023) Recent progress in nanotechnology-based drug carriers for resveratrol delivery. Drug Deliv. https:\/\/doi.org\/10.1080\/10717544.2023.2174206","journal-title":"Drug Deliv"},{"issue":"5","key":"4859_CR145","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3390\/12050946","volume":"12","author":"L Chen","year":"2007","unstructured":"Chen L, Zhang H-Y (2007) Cancer preventive mechanisms of the green tea polyphenol (\u2013Epigallocatechin-3-gallate. Molecules 12(5):946\u2013957. https:\/\/doi.org\/10.3390\/12050946","journal-title":"Molecules"},{"issue":"12","key":"4859_CR146","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","volume":"82","author":"BN Singh","year":"2011","unstructured":"Singh BN, Shankar S, Srivastava RK (2011) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82(12):1807\u201321. https:\/\/doi.org\/10.1016\/j.bcp.2011.07.093. (Epub 2011 Jul 30. PMID: 21827739; PMCID: PMC4082721)","journal-title":"Biochem Pharmacol"},{"issue":"14","key":"4859_CR147","doi-asserted-by":"publisher","first-page":"1201085","DOI":"10.3389\/fphar.2023.1201085","volume":"24","author":"D Li","year":"2023","unstructured":"Li D, Cao D, Cui Y, Sun Y, Jiang J, Cao X (2023) The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma. Front Pharmacol 24(14):1201085. https:\/\/doi.org\/10.3389\/fphar.2023.1201085. (PMID:37292151;PMCID:PMC10244546)","journal-title":"Front Pharmacol"},{"issue":"13","key":"4859_CR148","doi-asserted-by":"publisher","first-page":"5246","DOI":"10.3390\/molecules28135246","volume":"28","author":"M Kciuk","year":"2023","unstructured":"Kciuk M, Alam M, Ali N, Rashid S, G\u0142owacka P, Sundaraj R, Celik I, Yahya EB, Dubey A, Zerroug E, Kontek R (2023) Epigallocatechin-3-gallate therapeutic potential in cancer: mechanism of action and clinical implications. Molecules 28(13):5246. https:\/\/doi.org\/10.3390\/molecules28135246","journal-title":"Molecules"},{"issue":"1","key":"4859_CR149","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/13880209.2024.2406779","volume":"62","author":"W Sun","year":"2024","unstructured":"Sun W, Yang Y, Wang C, Liu M, Wang J, Qiao S, Jiang S (2024) Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment. Pharm Biol 62(1):676\u2013690. https:\/\/doi.org\/10.1080\/13880209.2024.2406779","journal-title":"Pharm Biol"},{"issue":"6","key":"4859_CR150","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29061373","volume":"29","author":"WH Talib","year":"2024","unstructured":"Talib WH, Awajan D, Alqudah A, Alsawwaf R, Althunibat R, Abu AlRoos M, Al Safadi A, Abu Asab S, Hadi RW, Al Kury LT (2024) Targeting cancer hallmarks with epigallocatechin gallate (EGCG): mechanistic basis and therapeutic targets. Molecules 29(6):1373. https:\/\/doi.org\/10.3390\/molecules29061373","journal-title":"Molecules"},{"issue":"2","key":"4859_CR151","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S2225-4110(16)30082-7","volume":"2","author":"JY Lee","year":"2012","unstructured":"Lee JY, Kim H, Song YS (2012) Genistein as a potential anticancer agent against ovarian cancer. J Tradit Complement Med 2(2):96\u2013104. https:\/\/doi.org\/10.1016\/S2225-4110(16)30082-7","journal-title":"J Tradit Complement Med"},{"issue":"3","key":"4859_CR152","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031114","volume":"26","author":"V Naponelli","year":"2025","unstructured":"Naponelli V, Piscazzi A, Mangieri D (2025) Cellular and molecular mechanisms modulated by genistein in cancer. Int J Mol Sci 26(3):1114. https:\/\/doi.org\/10.3390\/ijms26031114","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4859_CR153","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/13880209.2025.2469607","volume":"63","author":"Z Xiang","year":"2025","unstructured":"Xiang Z, Ma B, Pei X, Wang W, Gong W (2025) Mechanism of action of genistein on breast cancer and differential effects of different age stages. Pharm Biol 63(1):141\u2013155. https:\/\/doi.org\/10.1080\/13880209.2025.2469607","journal-title":"Pharm Biol"},{"issue":"2 Pt 1","key":"4859_CR154","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1753-4887.1998.tb01691.x","volume":"56","author":"SK Clinton","year":"1998","unstructured":"Clinton SK (1998) Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56(2 Pt 1):35\u201351. https:\/\/doi.org\/10.1111\/j.1753-4887.1998.tb01691.x. (PMID: 9529899)","journal-title":"Nutr Rev"},{"issue":"10","key":"4859_CR155","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1177\/153537020222701003","volume":"227","author":"E Giovannucci","year":"2002","unstructured":"Giovannucci E (2002) A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med (Maywood) 227(10):852\u2013859. https:\/\/doi.org\/10.1177\/153537020222701003","journal-title":"Exp Biol Med (Maywood)"},{"key":"4859_CR156","doi-asserted-by":"publisher","first-page":"114428","DOI":"10.1016\/j.biopha.2023.114428","volume":"161","author":"G Ozkan","year":"2023","unstructured":"Ozkan G, G\u00fcnal-K\u00f6ro\u011flu D, Karadag A, Capanoglu E, Cardoso SM, Al-Omari B, Calina D, Sharifi-Rad J, Cho WC (2023) mechanistic updated overview on lycopene as potential anticancer agent. Biomed Pharmacother 161:114428. https:\/\/doi.org\/10.1016\/j.biopha.2023.114428. (ISSN 0753-3322)","journal-title":"Biomed Pharmacother"},{"issue":"2024","key":"4859_CR157","doi-asserted-by":"publisher","first-page":"6252426","DOI":"10.1155\/2024\/6252426","volume":"8","author":"MO Shafe","year":"2024","unstructured":"Shafe MO, Gumede NM, Nyakudya TT, Chivandi E (2024) Lycopene: a potent antioxidant with multiple health benefits. J Nutr Metab 8(2024):6252426. https:\/\/doi.org\/10.1155\/2024\/6252426. (PMID:38883868;PMCID:PMC11179732)","journal-title":"J Nutr Metab"},{"issue":"2","key":"4859_CR158","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3892\/or.2017.5766","volume":"38","author":"M Hashemzaei","year":"2017","unstructured":"Hashemzaei M, Delarami Far A, Yari A, Heravi RE, Tabrizian K, Taghdisi SM, Sadegh SE, Tsarouhas K, Kouretas D, Tzanakakis G, Nikitovic D, Anisimov NY, Spandidos DA, Tsatsakis AM, Rezaee R (2017) Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo. Oncol Rep 38(2):819\u2013828. https:\/\/doi.org\/10.3892\/or.2017.5766. (Epub 2017 Jun 28. PMID: 28677813; PMCID: PMC5561933)","journal-title":"Oncol Rep"},{"key":"4859_CR159","doi-asserted-by":"publisher","first-page":"109604","DOI":"10.1016\/j.biopha.2019.109604","volume":"121","author":"S-M Tang","year":"2020","unstructured":"Tang S-M, Deng X-T, Zhou J, Li Q-P, Ge X-X, Miao L (2020) Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother 121:109604. https:\/\/doi.org\/10.1016\/j.biopha.2019.109604","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4859_CR160","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s41120-022-00058-1","volume":"8","author":"C Kemper","year":"2022","unstructured":"Kemper C, Behnam D, Brothers S, Wahlestedt C, Volmar CH, Bennett D, Hayward M (2022) Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM). AAPS Open 8(1):11","journal-title":"AAPS Open"},{"issue":"11","key":"4859_CR161","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111631","volume":"16","author":"MA Mirza","year":"2023","unstructured":"Mirza MA, Mahmood S, Hilles AR, Ali A, Khan MZ, Zaidi SAA, Iqbal Z, Ge Y (2023) Quercetin as a therapeutic product: evaluation of its pharmacological action and clinical applications\u2014a review. Pharmaceuticals 16(11):1631","journal-title":"Pharmaceuticals"},{"issue":"9","key":"4859_CR162","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.3390\/molecules23092346","volume":"23","author":"ZY Cai","year":"2018","unstructured":"Cai ZY, Li XM, Liang JP, Xiang LP, Wang KR, Shi YL, Yang R, Shi M, Ye JH, Lu JL, Zheng XQ (2018) Bioavailability of tea catechins and its improvement. Molecules 23(9):2346","journal-title":"Molecules"},{"key":"4859_CR163","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.trac.2019.05.037","volume":"118","author":"F Chemat","year":"2019","unstructured":"Chemat F, Abert-Vian M, Fabiano-Tixier AS, Strube J, Uhlenbrock L, Gunjevic V, Cravotto G (2019) Green extraction of natural products. Origins, current status, and future challenges. TrAC Trends Anal Chem 118:248\u2013263","journal-title":"TrAC Trends Anal Chem"},{"issue":"6","key":"4859_CR164","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1002\/med.21969","volume":"43","author":"JT Burcher","year":"2023","unstructured":"Burcher JT, DeLiberto LK, Allen AM, Kilpatrick KL, Bishayee A (2023) Bioactive phytocompounds for oral cancer prevention and treatment: a comprehensive and critical evaluation. Med Res Rev 43(6):2025\u20132085","journal-title":"Med Res Rev"},{"key":"4859_CR165","doi-asserted-by":"publisher","first-page":"1156538","DOI":"10.3389\/fphar.2023.1156538","volume":"14","author":"Y Li","year":"2023","unstructured":"Li Y, Zhang X, Wang Z, Li B, Zhu H (2023) Modulation of redox homeostasis: a strategy to overcome cancer drug resistance. Front Pharmacol 14:1156538","journal-title":"Front Pharmacol"},{"key":"4859_CR166","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103095","volume":"71","author":"C Favari","year":"2024","unstructured":"Favari C, de Alvarenga JFR, S\u00e1nchez-Mart\u00ednez L, Tosi N, Mignogna C, Cremonini E, Manach C, Bresciani L, Del Rio D, Mena P (2024) Factors driving the inter-individual variability in the metabolism and bioavailability of (poly) phenolic metabolites: a systematic review of human studies. Redox Biol 71:103095","journal-title":"Redox Biol"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-025-04859-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00280-025-04859-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-025-04859-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:03:47Z","timestamp":1770105827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00280-025-04859-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":165,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4859"],"URL":"https:\/\/doi.org\/10.1007\/s00280-025-04859-5","relation":{},"ISSN":["1432-0843"],"issn-type":[{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"assertion":[{"value":"5 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"17"}}