{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:55:22Z","timestamp":1790711722914,"version":"4.1.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1007\/s00281-009-0189-9","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T19:47:17Z","timestamp":1265140037000},"page":"43-53","source":"Crossref","is-referenced-by-count":140,"title":["Th17 cytokines and arthritis"],"prefix":"10.1007","volume":"32","author":[{"given":"Erik","family":"Lubberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,4]]},"reference":[{"key":"189_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-3083.1999.00581.x","volume":"50","author":"T Aarvak","year":"1999","unstructured":"Aarvak T, Chabaud M, Kallberg E, Miossec P, Natvig JB (1999) Change in the Th1\/Th2 phenotype of memory T-cell clones from rheumatoid arthritis synovium. Scand J Immunol 50:1\u20139","journal-title":"Scand J Immunol"},{"key":"189_CR2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1172\/JCI32639","volume":"118","author":"S Abdollahi-Roodsaz","year":"2008","unstructured":"Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ, Ribeiro-Dias F, van den Berg WB (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118:205\u2013216","journal-title":"J Clin Invest"},{"key":"189_CR3","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/art.23557","volume":"58","author":"WH Abdulahad","year":"2008","unstructured":"Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG (2008) Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. Arthritis Rheum 58:2196\u20132205","journal-title":"Arthritis Rheum"},{"key":"189_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/art.1780380202","volume":"38","author":"WP Arend","year":"1995","unstructured":"Arend WP, Dayer JM (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum 38:151\u2013160","journal-title":"Arthritis Rheum"},{"key":"189_CR5","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1073\/pnas.0902745106","volume":"106","author":"SZ Ben-Sasson","year":"2009","unstructured":"Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE (2009) IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci USA 106:7119\u20137124","journal-title":"Proc Natl Acad Sci USA"},{"key":"189_CR6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jlb.54.5.399","volume":"54","author":"MP Bombara","year":"1993","unstructured":"Bombara MP, Webb DL, Conrad P, Marlor CW, Sarr T, Ranges GE, Aune TM, Greve JM, Blue ML (1993) Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J Leukoc Biol 54:399\u2013406","journal-title":"J Leukoc Biol"},{"key":"189_CR7","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","volume":"118","author":"FM Brennan","year":"2008","unstructured":"Brennan FM, McInnes IB (2008) Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118:3537\u20133545","journal-title":"J Clin Invest"},{"key":"189_CR8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/art.10173","volume":"46","author":"KA Bush","year":"2002","unstructured":"Bush KA, Farmer KM, Walker JS, Kirkham BW (2002) Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 46:802\u2013805","journal-title":"Arthritis Rheum"},{"key":"189_CR9","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2249.2001.01469.x","volume":"123","author":"KA Bush","year":"2001","unstructured":"Bush KA, Walker JS, Lee CS, Kirkham BW (2001) Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease. Clin Exp Immunol 123:487\u2013495","journal-title":"Clin Exp Immunol"},{"key":"189_CR10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E","volume":"42","author":"M Chabaud","year":"1999","unstructured":"Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, Miossec P (1999) Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42:963\u2013970","journal-title":"Arthritis Rheum"},{"key":"189_CR11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","volume":"30","author":"Y Chung","year":"2009","unstructured":"Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C (2009) Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30:576\u2013587","journal-title":"Immunity"},{"key":"189_CR12","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/art.24389","volume":"60","author":"F Ciccia","year":"2009","unstructured":"Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, Peralta S, Franco V, Giardina E, Craxi A, Pitzalis C, Triolo G (2009) Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 60:955\u2013965","journal-title":"Arthritis Rheum"},{"key":"189_CR13","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1002\/art.23972","volume":"58","author":"G Codolo","year":"2008","unstructured":"Codolo G, Amedei A, Steere AC, Papinutto E, Cappon A, Polenghi A, Benagiano M, Paccani SR, Sambri V, Del Prete G, Baldari CT, Zanotti G, Montecucco C, D'Elios MM, de Bernard M (2008) Borrelia burgdorferi NapA-driven Th17 cell inflammation in Lyme arthritis. Arthritis Rheum 58:3609\u20133617","journal-title":"Arthritis Rheum"},{"key":"189_CR14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/art.25043","volume":"62","author":"EM Colin","year":"2010","unstructured":"Colin EM, Asmawidjaja PS, Van Hamburg JP, Mus AMC, van Driel M, Hazes JMW, van Leeuwen JPTM, Lubberts E (2010) 1, 25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 62:132\u2013142","journal-title":"Arthritis Rheum"},{"key":"189_CR15","doi-asserted-by":"crossref","unstructured":"Cornelissen F, Mus AMC, Asmawidjaja PS, van Hamburg JP, Tocker J, Luberts E (2009) Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and ROR\u03b3t in \u03b3\u03b4 T cells. Arthritis Res Ther 11(6):R194","DOI":"10.1186\/ar2893"},{"key":"189_CR16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/art.24503","volume":"60","author":"NA Daha","year":"2009","unstructured":"Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE (2009) Confirmation of STAT4, IL2\/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. Arthritis Rheum 60:1255\u20131260","journal-title":"Arthritis Rheum"},{"key":"189_CR17","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.4049\/jimmunol.172.10.6435","volume":"172","author":"IM Kleer de","year":"2004","unstructured":"de Kleer IM, Wedderburn LR, Taams LS, Patel A, Varsani H, Klein M, de Jager W, Pugayung G, Giannoni F, Rijkers G, Albani S, Kuis W, Prakken B (2004) CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 172:6435\u20136443","journal-title":"J Immunol"},{"key":"189_CR18","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/art.1780391204","volume":"39","author":"RJ Dolhain","year":"1996","unstructured":"Dolhain RJ, van der Heiden AN, ter Haar NT, Breedveld FC, Miltenburg AM (1996) Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 39:1961\u20131969","journal-title":"Arthritis Rheum"},{"key":"189_CR19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4049\/jimmunol.181.1.329","volume":"181","author":"PD Doodes","year":"2008","unstructured":"Doodes PD, Cao Y, Hamel KM, Wang Y, Farkas B, Iwakura Y, Finnegan A (2008) Development of proteoglycan-induced arthritis is independent of IL-17. J Immunol 181:329\u2013337","journal-title":"J Immunol"},{"key":"189_CR20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1767","volume":"10","author":"T Duhen","year":"2009","unstructured":"Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F (2009) Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 10:857\u2013863","journal-title":"Nat Immunol"},{"key":"189_CR21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356\u2013361","journal-title":"Nature"},{"key":"189_CR22","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1002\/art.24126","volume":"58","author":"M Fujimoto","year":"2008","unstructured":"Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T (2008) Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum 58:3710\u20133719","journal-title":"Arthritis Rheum"},{"key":"189_CR23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.24220","volume":"60","author":"L Geboes","year":"2009","unstructured":"Geboes L, Dumoutier L, Kelchtermans H, Schurgers E, Mitera T, Renauld JC, Matthys P (2009) Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL\/6 mice. Arthritis Rheum 60:390\u2013395","journal-title":"Arthritis Rheum"},{"key":"189_CR24","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.4049\/jimmunol.178.6.3822","volume":"178","author":"D Herber","year":"2007","unstructured":"Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K (2007) IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 178:3822\u20133830","journal-title":"J Immunol"},{"key":"189_CR25","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","volume":"204","author":"K Hirota","year":"2007","unstructured":"Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204:2803\u20132812","journal-title":"J Exp Med"},{"key":"189_CR26","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI20742","volume":"114","author":"R Horai","year":"2004","unstructured":"Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, Nambu A, Saijo S, Kotaki H, Sudo K, Okahara A, Tanioka H, Ikuse T, Ishii N, Schwartzberg PL, Abe R, Iwakura Y (2004) TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114:1603\u20131611","journal-title":"J Clin Invest"},{"key":"189_CR27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","volume":"9","author":"HC Hsu","year":"2008","unstructured":"Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, Le TV, Lorenz RG, Xu H, Kolls JK, Carter RH, Chaplin DD, Williams RW, Mountz JD (2008) Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 9:166\u2013175","journal-title":"Nat Immunol"},{"key":"189_CR28","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1093\/emboj\/20.19.5332","volume":"20","author":"SG Hymowitz","year":"2001","unstructured":"Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA (2001) IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 20:5332\u20135341","journal-title":"EMBO J"},{"key":"189_CR29","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.20965","volume":"52","author":"H Ikeuchi","year":"2005","unstructured":"Ikeuchi H, Kuroiwa T, Hiramatsu N, Kaneko Y, Hiromura K, Ueki K, Nojima Y (2005) Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 52:1037\u20131046","journal-title":"Arthritis Rheum"},{"key":"189_CR30","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.165.11.6107","volume":"165","author":"C Infarte-Durante","year":"2000","unstructured":"Infarte-Durante C, Horton HF, Byrne MC, Kamradt T (2000) Microbial lipopeptides induce the production of IL-17 in T cells. J Immunol 165:6107\u20136115","journal-title":"J Immunol"},{"key":"189_CR31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","volume":"30","author":"H Ishigame","year":"2009","unstructured":"Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y (2009) Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30:108\u2013119","journal-title":"Immunity"},{"key":"189_CR32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","author":"II Ivanov","year":"2006","unstructured":"Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121\u20131133","journal-title":"Cell"},{"key":"189_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","volume":"226","author":"Y Iwakura","year":"2008","unstructured":"Iwakura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 226:57\u201379","journal-title":"Immunol Rev"},{"key":"189_CR34","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.23655","volume":"58","author":"C Jandus","year":"2008","unstructured":"Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P (2008) Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 58:2307\u20132317","journal-title":"Arthritis Rheum"},{"key":"189_CR35","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.4049\/jimmunol.0804350","volume":"182","author":"E Jang","year":"2009","unstructured":"Jang E, Cho SH, Park H, Paik DJ, Kim JM, Youn J (2009) A positive feedback loop of IL-21 signaling provoked by homeostatic CD4\u2009+\u2009CD25- T cell expansion is essential for the development of arthritis in autoimmune K\/BxN mice. J Immunol 182:4649\u20134656","journal-title":"J Immunol"},{"key":"189_CR36","doi-asserted-by":"crossref","first-page":"7849","DOI":"10.4049\/jimmunol.178.12.7849","volume":"178","author":"HK Kang","year":"2007","unstructured":"Kang HK, Liu M, Datta SK (2007) Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 178:7849\u20137858","journal-title":"J Immunol"},{"key":"189_CR37","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.21749","volume":"54","author":"BW Kirkham","year":"2006","unstructured":"Kirkham BW, Lassere MN, Edmonds JP, Juhasz KM, Bird PA, Lee CS, Shnier R, Portek IJ (2006) Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). Arthritis Rheum 54:1122\u20131131","journal-title":"Arthritis Rheum"},{"key":"189_CR38","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2008-01-133967","volume":"112","author":"HJ Koenen","year":"2008","unstructured":"Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I (2008) Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 112:2340\u20132352","journal-title":"Blood"},{"key":"189_CR39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","volume":"448","author":"T Korn","year":"2007","unstructured":"Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484\u2013487","journal-title":"Nature"},{"key":"189_CR40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","volume":"27","author":"T Korn","year":"2009","unstructured":"Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27:485\u2013517","journal-title":"Annu Rev Immunol"},{"key":"189_CR41","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","volume":"103","author":"S Kotake","year":"1999","unstructured":"Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345\u20131352","journal-title":"J Clin Invest"},{"key":"189_CR42","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1128\/CVI.00129-08","volume":"15","author":"NJ Kotloski","year":"2008","unstructured":"Kotloski NJ, Nardelli DT, Peterson SH, Torrealba JR, Warner TF, Callister SM, Schell RF (2008) Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species. Clin Vaccine Immunol 15:1199\u20131207","journal-title":"Clin Vaccine Immunol"},{"key":"189_CR43","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.4049\/jimmunol.179.12.8098","volume":"179","author":"K Kreymborg","year":"2007","unstructured":"Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, Heppner FL, Renauld JC, Becher B (2007) IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol 179:8098\u20138104","journal-title":"J Immunol"},{"key":"189_CR44","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1084\/jem.20080159","volume":"205","author":"MA Kroenke","year":"2008","unstructured":"Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM (2008) IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 205:1535\u20131541","journal-title":"J Exp Med"},{"key":"189_CR45","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/1529-0131(200011)43:11<2455::AID-ANR12>3.0.CO;2-K","volume":"43","author":"K Kurasawa","year":"2000","unstructured":"Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y, Takabayashi K, Iwamoto I (2000) Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 43:2455\u20132463","journal-title":"Arthritis Rheum"},{"key":"189_CR46","doi-asserted-by":"crossref","first-page":"14993","DOI":"10.1073\/pnas.0806044105","volume":"105","author":"Q Lai Kwan Lam","year":"2008","unstructured":"Lai Kwan Lam Q, King Hung Ko O, Zheng BJ, Lu L (2008) Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc Natl Acad Sci USA 105:14993\u201314998","journal-title":"Proc Natl Acad Sci USA"},{"key":"189_CR47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/art.10083","volume":"46","author":"RB Landewe","year":"2002","unstructured":"Landewe RB, Boers M, Verhoeven AC, Westhovens R, van de Laar MA, Markusse HM, van Denderen JC, Westedt ML, Peeters AJ, Dijkmans BA, Jacobs P, Boonen A, van der Heijde DM, van der Linden S (2002) COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum 46:347\u2013356","journal-title":"Arthritis Rheum"},{"key":"189_CR48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0002-9343(01)00872-5","volume":"111","author":"LR Lard","year":"2001","unstructured":"Lard LR, Visser H, Speyer I, vander Horst-Bruinsma IE, Zwinderman AH, Breedveld FC, Hazes JM (2001) Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. Am J Med 111:446\u2013451","journal-title":"Am J Med"},{"key":"189_CR49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","volume":"30","author":"YK Lee","year":"2008","unstructured":"Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT (2008) Late developmental plasticity in the T helper 17 lineage. Immunity 30:92\u2013107","journal-title":"Immunity"},{"key":"189_CR50","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/eji.200838541","volume":"38","author":"MH Lexberg","year":"2008","unstructured":"Lexberg MH, Taubner A, Forster A, Albrecht I, Richter A, Kamradt T, Radbruch A, Chang HD (2008) Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol 38:2654\u20132664","journal-title":"Eur J Immunol"},{"key":"189_CR51","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","volume":"203","author":"SC Liang","year":"2006","unstructured":"Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271\u20132279","journal-title":"J Exp Med"},{"key":"189_CR52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cyto.2007.09.014","volume":"41","author":"E Lubberts","year":"2008","unstructured":"Lubberts E (2008) IL-17\/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 41:84\u201391","journal-title":"Cytokine"},{"key":"189_CR53","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.4049\/jimmunol.167.2.1004","volume":"167","author":"E Lubberts","year":"2001","unstructured":"Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB (2001) IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol 167:1004\u20131013","journal-title":"J Immunol"},{"key":"189_CR54","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/art.20001","volume":"50","author":"E Lubberts","year":"2004","unstructured":"Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB (2004) Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50:650\u2013659","journal-title":"Arthritis Rheum"},{"key":"189_CR55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/ar1478","volume":"7","author":"E Lubberts","year":"2005","unstructured":"Lubberts E, Koenders MI, van den Berg WB (2005) The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 7:29\u201337","journal-title":"Arthritis Res Ther"},{"key":"189_CR56","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.175.5.3360","volume":"175","author":"E Lubberts","year":"2005","unstructured":"Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, Kolls JK (2005) Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis. J Immunol 175:3360\u20133368","journal-title":"J Immunol"},{"key":"189_CR57","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.20071258","volume":"205","author":"D Luger","year":"2008","unstructured":"Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205:799\u2013810","journal-title":"J Exp Med"},{"key":"189_CR58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/eji.200838475","volume":"39","author":"N Martin-Orozco","year":"2009","unstructured":"Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C (2009) Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 39:216\u2013224","journal-title":"Eur J Immunol"},{"key":"189_CR59","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","volume":"8","author":"MJ McGeachy","year":"2007","unstructured":"McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ (2007) TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8:1390\u20131397","journal-title":"Nat Immunol"},{"key":"189_CR60","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/ar115","volume":"2","author":"IB McInnes","year":"2000","unstructured":"McInnes IB, Leung BP, Liew FY (2000) Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells. Arthritis Res 2:374\u2013378","journal-title":"Arthritis Res"},{"key":"189_CR61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cyto.2006.09.001","volume":"35","author":"JA Meyers","year":"2006","unstructured":"Meyers JA, Mangini AJ, Nagai T, Roff CF, Sehy D, van Seventer GA, van Seventer JM (2006) Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC. Cytokine 35:235\u2013246","journal-title":"Cytokine"},{"key":"189_CR62","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/art.10816","volume":"48","author":"P Miossec","year":"2003","unstructured":"Miossec P (2003) Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum 48:594\u2013601","journal-title":"Arthritis Rheum"},{"key":"189_CR63","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1084\/jem.20070994","volume":"204","author":"J Moisan","year":"2007","unstructured":"Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC (2007) Ets-1 is a negative regulator of Th17 differentiation. J Exp Med 204:2825\u20132835","journal-title":"J Exp Med"},{"key":"189_CR64","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/1529-0131(199809)41:9<1669::AID-ART19>3.0.CO;2-G","volume":"41","author":"Y Morita","year":"1998","unstructured":"Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, Shibuya K, Maruyama K, Makino H (1998) Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheum 41:1669\u20131676","journal-title":"Arthritis Rheum"},{"key":"189_CR65","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1084\/jem.20030896","volume":"198","author":"CA Murphy","year":"2003","unstructured":"Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198:1951\u20131957","journal-title":"J Exp Med"},{"key":"189_CR66","unstructured":"Mus AMC et al (2010) Arthritis Rheum (in press)"},{"key":"189_CR67","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1073\/pnas.1035999100","volume":"100","author":"S Nakae","year":"2003","unstructured":"Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y (2003) IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 100:5986\u20135990","journal-title":"Proc Natl Acad Sci USA"},{"key":"189_CR68","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/art.23214","volume":"58","author":"CQ Nguyen","year":"2008","unstructured":"Nguyen CQ, Hu MH, Li Y, Stewart C, Peck AB (2008) Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice. Arthritis Rheum 58:734\u2013743","journal-title":"Arthritis Rheum"},{"key":"189_CR69","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/art.23291","volume":"58","author":"K Nistala","year":"2008","unstructured":"Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR (2008) Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 58:875\u2013887","journal-title":"Arthritis Rheum"},{"key":"189_CR70","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1084\/jem.20072707","volume":"205","author":"CA Notley","year":"2008","unstructured":"Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, Williams RO (2008) Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205:2491\u20132497","journal-title":"J Exp Med"},{"key":"189_CR71","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","volume":"448","author":"R Nurieva","year":"2007","unstructured":"Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480\u2013483","journal-title":"Nature"},{"key":"189_CR72","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.immuni.2008.07.018","volume":"29","author":"H Ogura","year":"2008","unstructured":"Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, Nishihara M, Iwakura Y, Hirano T (2008) Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29:628\u2013636","journal-title":"Immunity"},{"key":"189_CR73","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/ar2406","volume":"10","author":"G Parsonage","year":"2008","unstructured":"Parsonage G, Filer A, Bik M, Hardie D, Lax S, Howlett K, Church LD, Raza K, Wong SH, Trebilcock E, Scheel-Toellner D, Salmon M, Lord JM, Buckley CD (2008) Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. Arthritis Res Ther 10:R47","journal-title":"Arthritis Res Ther"},{"key":"189_CR74","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.4049\/jimmunol.181.5.3137","volume":"181","author":"S Radhakrishnan","year":"2008","unstructured":"Radhakrishnan S, Cabrera R, Schenk EL, Nava-Parada P, Bell MP, Van Keulen VP, Marler RJ, Felts SJ, Pease LR (2008) Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 181:3137\u20133147","journal-title":"J Immunol"},{"key":"189_CR75","doi-asserted-by":"crossref","first-page":"e5903","DOI":"10.1371\/journal.pone.0005903","volume":"4","author":"TR Radstake","year":"2009","unstructured":"Radstake TR, van Bon L, Broen J, Hussiani A, Hesselstrand R, Wuttge DM, Deng Y, Simms R, Lubberts E, Lafyatis R (2009) The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PloS one 4:e5903","journal-title":"PloS one"},{"key":"189_CR76","doi-asserted-by":"crossref","first-page":"R784","DOI":"10.1186\/ar1733","volume":"7","author":"K Raza","year":"2005","unstructured":"Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, Akbar AN, Lord JM, Gordon C, Buckley CD, Salmon M (2005) Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 7:R784\u2013R795","journal-title":"Arthritis Res Ther"},{"key":"189_CR77","first-page":"667","volume":"3","author":"JC Renauld","year":"2003","unstructured":"Renauld JC (2003) Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev 3:667\u2013676","journal-title":"Nat Rev"},{"key":"189_CR78","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1084\/jem.20050085","volume":"201","author":"CR Ruprecht","year":"2005","unstructured":"Ruprecht CR, Gattorno M, Ferlito F, Gregorio A, Martini A, Lanzavecchia A, Sallusto F (2005) Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med 201:1793\u20131803","journal-title":"J Exp Med"},{"key":"189_CR79","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.4049\/jimmunol.181.4.2898","volume":"181","author":"A Sakai","year":"2008","unstructured":"Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S (2008) Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol 181:2898\u20132906","journal-title":"J Immunol"},{"key":"189_CR80","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/ard.2007.075424","volume":"67","author":"AH Sawalha","year":"2008","unstructured":"Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DR, James JA, Merrill JT, Lipsky P, Harley JB (2008) Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 67:458\u2013461","journal-title":"Ann Rheum Dis"},{"key":"189_CR81","first-page":"2285","volume":"34","author":"R Singh","year":"2007","unstructured":"Singh R, Aggarwal A, Misra R (2007) Th1\/Th17 cytokine profiles in patients with reactive arthritis\/undifferentiated spondyloarthropathy. J Rheumatol 34:2285\u20132290","journal-title":"J Rheumatol"},{"key":"189_CR82","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/1098-1004(200007)16:1<49::AID-HUMU9>3.0.CO;2-Z","volume":"16","author":"KE Sullivan","year":"2000","unstructured":"Sullivan KE, Piliero LM, Dharia T, Goldman D, Petri MA (2000) 3\u2032 polymorphisms of ETS1 are associated with different clinical phenotypes in SLE. Hum Mutat 16:49\u201353","journal-title":"Hum Mutat"},{"key":"189_CR83","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.20060285","volume":"203","author":"C Sutton","year":"2006","unstructured":"Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC (2006) A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203:1685\u20131691","journal-title":"J Exp Med"},{"key":"189_CR84","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.20080588","volume":"205","author":"N Takahashi","year":"2008","unstructured":"Takahashi N, Vanlaere I, de Rycke R, Cauwels A, Joosten LA, Lubberts E, van den Berg WB, Libert C (2008) IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med 205:1755\u20131761","journal-title":"J Exp Med"},{"key":"189_CR85","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2353\/ajpath.2007.070004","volume":"171","author":"CN Tran","year":"2007","unstructured":"Tran CN, Lundy SK, White PT, Endres JL, Motyl CD, Gupta R, Wilke CM, Shelden EA, Chung KC, Urquhart AG, Fox DA (2007) Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am J Pathol 171:1588\u20131598","journal-title":"Am J Pathol"},{"key":"189_CR86","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","volume":"10","author":"S Trifari","year":"2009","unstructured":"Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H (2009) Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nature Immunol 10:864\u2013871","journal-title":"Nature Immunol"},{"key":"189_CR87","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/eji.200737840","volume":"38","author":"JP Hamburg van","year":"2008","unstructured":"van Hamburg JP, de Bruijn MJ, de Almeida CR, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol 38:2573\u20132586","journal-title":"Eur J Immunol"},{"key":"189_CR88","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/art.24329","volume":"60","author":"JP Hamburg van","year":"2009","unstructured":"van Hamburg JP, Mus AM, de Bruijn MJ, de Vogel L, Boon L, Cornelissen F, Asmawidjaja P, Hendriks RW, Lubberts E (2009) GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum 60:750\u2013759","journal-title":"Arthritis Rheum"},{"key":"189_CR89","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.10117","volume":"46","author":"H Visser","year":"2002","unstructured":"Visser H, le Cessie S, Vos K, Breedveld FC, Hazes JM (2002) How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum 46:357\u2013365","journal-title":"Arthritis Rheum"},{"key":"189_CR90","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/intimm\/dxh295","volume":"17","author":"D Wang","year":"2005","unstructured":"Wang D, John SA, Clements JL, Percy DH, Barton KP, Garrett-Sinha LA (2005) Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. Int Immunol 17:1179\u20131191","journal-title":"Int Immunol"},{"key":"189_CR91","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1002\/art.24658","volume":"60","author":"R Webb","year":"2009","unstructured":"Webb R, Merrill JT, Kelly JA, Sestak A, Kaufman KM, Langefeld CD, Ziegler J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcon-Riquelme ME, James JA, Gilkeson GS, Jacob CO, Moser KL, Gaffney PM, Vyse TJ, Nath SK, Lipsky P, Harley JB, Sawalha AH (2009) A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum 60:2402\u20132407","journal-title":"Arthritis Rheum"},{"key":"189_CR92","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","volume":"30","author":"G Wei","year":"2009","unstructured":"Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K (2009) Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30:155\u2013167","journal-title":"Immunity"},{"key":"189_CR93","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","volume":"36","author":"K Wolk","year":"2006","unstructured":"Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309\u20131323","journal-title":"Eur J Immunol"},{"key":"189_CR94","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1191\/096120300678828703","volume":"9","author":"CK Wong","year":"2000","unstructured":"Wong CK, Ho CY, Li EK, Lam CW (2000) Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9:589\u2013593","journal-title":"Lupus"},{"key":"189_CR95","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","volume":"178","author":"L Xu","year":"2007","unstructured":"Xu L, Kitani A, Fuss I, Strober W (2007) Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 178:6725\u20136729","journal-title":"J Immunol"},{"key":"189_CR96","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1136\/ard.2007.080341","volume":"67","author":"H Yamada","year":"2008","unstructured":"Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi JI, Kaibara N, Hori A, Iwamoto Y, Yoshikai Y (2008) Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis 67:1299\u20131304","journal-title":"Ann Rheum Dis"},{"key":"189_CR97","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20071978","volume":"205","author":"XO Yang","year":"2008","unstructured":"Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C (2008) Regulation of inflammatory responses by IL-17F. J Exp Med 205:1063\u20131075","journal-title":"J Exp Med"},{"key":"189_CR98","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","volume":"28","author":"XO Yang","year":"2008","unstructured":"Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28:29\u201339","journal-title":"Immunity"},{"key":"189_CR99","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","volume":"8","author":"L Zhou","year":"2007","unstructured":"Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nature Immunol 8:967\u2013974","journal-title":"Nature Immunol"},{"key":"189_CR100","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.164.5.2832","volume":"164","author":"M Ziolkowska","year":"2000","unstructured":"Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, Chwalinska-Sadowska H, Maslinski W (2000) High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 164:2832\u20132838","journal-title":"J Immunol"},{"key":"189_CR101","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.4049\/jimmunol.0801967","volume":"182","author":"S Zrioual","year":"2009","unstructured":"Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P (2009) Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J Immunol 182:3112\u20133120","journal-title":"J Immunol"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00281-009-0189-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:09:36Z","timestamp":1551139776000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00281-009-0189-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,4]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["189"],"URL":"https:\/\/doi.org\/10.1007\/s00281-009-0189-9","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,4]]}}}