{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:25:43Z","timestamp":1791851143270,"version":"4.3.4"},"reference-count":173,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00281-014-0436-6","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:58:05Z","timestamp":1406102285000},"page":"461-478","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The immunopathology of ANCA-associated vasculitis"],"prefix":"10.1007","volume":"36","author":[{"given":"Eoin F.","family":"McKinney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Willcocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Broecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G. C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,24]]},"reference":[{"key":"436_CR1","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1056\/NEJM199711203372106","volume":"337","author":"JC Jennette","year":"1997","unstructured":"Jennette JC, Falk RJ (1997) Small-vessel vasculitis. N Engl J Med 337:1512\u20131523","journal-title":"N Engl J Med"},{"key":"436_CR2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1523-1755.1998.00807.x","volume":"53","author":"EC Hagen","year":"1998","unstructured":"Hagen EC et al (1998) Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC\/BCR project for ANCA assay standardization. Kidney Int 53:743\u2013753","journal-title":"Kidney Int"},{"key":"436_CR3","first-page":"111","volume":"16","author":"GS Hoffman","year":"1998","unstructured":"Hoffman GS (1998) Classification of the systemic vasculitides: antineutrophil cytoplasmic antibodies, consensus and controversy. Clin Exp Rheumatol 16:111\u2013115","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/hci015","volume":"98","author":"SE Lane","year":"2005","unstructured":"Lane SE, Watts RA, Shepstone L, Scott DG (2005) Primary systemic vasculitis: clinical features and mortality. QJM 98:97\u2013111","journal-title":"QJM"},{"key":"436_CR5","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1017\/S0022215100118407","volume":"105","author":"P McBride","year":"1991","unstructured":"McBride P (1991) Photographs of a case of rapid destruction of the nose and face. 1897. J Laryngol Otol 105:1120","journal-title":"J Laryngol Otol"},{"key":"436_CR6","first-page":"484","volume":"1","author":"AMR Kussmaul","year":"1836","unstructured":"Kussmaul AMR (1836) Uber eine bisher nicht beschreibene eigenthumliche Arterienerkrankrung (Periarteritis Nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskellahmung einhergeht. Dtsch Arch Klin Med 1:484\u2013518","journal-title":"Dtsch Arch Klin Med"},{"key":"436_CR7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF01947911","volume":"246","author":"F Wohlwill","year":"1923","unstructured":"Wohlwill F (1923) About a form of periarteritis nodosa that can only be detected histologically. Virchows Arch Pathol Anat Physiol Klin Med 246:377\u2013411","journal-title":"Virchows Arch Pathol Anat Physiol Klin Med"},{"key":"436_CR8","first-page":"455","volume":"42","author":"H Klinger","year":"1931","unstructured":"Klinger H (1931) Borderline variants of periarteritis nodosa. Frankf Z Pathol 42:455\u2013480","journal-title":"Frankf Z Pathol"},{"key":"436_CR9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/rheumatology\/kel258","volume":"45","author":"A Woywodt","year":"2006","unstructured":"Woywodt A, Matteson EL (2006) Wegener\u2019s granulomatosis\u2014probing the untold past of the man behind the eponym. Rheumatology (Oxford) 45:1303\u20131306","journal-title":"Rheumatology (Oxford)"},{"key":"436_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4757-9182-2_1","volume":"336","author":"RA DeRemee","year":"1993","unstructured":"DeRemee RA (1993) Friedrich Wegener and the nature of fame. Adv Exp Med Biol 336:1\u20134","journal-title":"Adv Exp Med Biol"},{"key":"436_CR11","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/S0140-6736(06)68583-8","volume":"367","author":"A Woywodt","year":"2006","unstructured":"Woywodt A, Haubitz M, Haller H, Matteson EL (2006) Wegener\u2019s granulomatosis. Lancet 367:1362\u20131366","journal-title":"Lancet"},{"key":"436_CR12","first-page":"533","volume":"58","author":"GC Godman","year":"1954","unstructured":"Godman GC, Churg J (1954) Wegener\u2019s granulomatosis: pathology and review of the literature. AMA Arch Pathol 58:533\u2013553","journal-title":"AMA Arch Pathol"},{"key":"436_CR13","first-page":"30","volume":"102","author":"F Wegener","year":"1939","unstructured":"Wegener F (1939) About a peculiar rhinogenic granulomatosis with marked involvement of the arterial system and kidneys. Beitr Pathol Anat 102:30\u201368","journal-title":"Beitr Pathol Anat"},{"key":"436_CR14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00175962","volume":"247","author":"F Wegener","year":"1990","unstructured":"Wegener F (1990) Wegener\u2019s granulomatosis. Thoughts and observations of a pathologist. Eur Arch Otorhinolaryngol 247:133\u2013142","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"436_CR15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-129-5-199809010-00001","volume":"129","author":"JK Rao","year":"1998","unstructured":"Rao JK, Allen NB, Pincus T (1998) Limitations of the 1990 American College of Rheumatology classification criteria in the diagnosis of vasculitis. Ann Intern Med 129:345\u2013352","journal-title":"Ann Intern Med"},{"key":"436_CR16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/art.1780370206","volume":"37","author":"JC Jennette","year":"1994","unstructured":"Jennette JC et al (1994) Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 37:187\u2013192","journal-title":"Arthritis Rheum"},{"key":"436_CR17","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/ard.59.6.478","volume":"59","author":"SF Sorensen","year":"2000","unstructured":"Sorensen SF, Slot O, Tvede N, Petersen J (2000) A prospective study of vasculitis patients collected in a five year period: evaluation of the Chapel Hill nomenclature. Ann Rheum Dis 59:478\u2013482","journal-title":"Ann Rheum Dis"},{"key":"436_CR18","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/rheumatology\/41.10.1138","volume":"41","author":"SE Lane","year":"2002","unstructured":"Lane SE, Watts RA, Barker TH, Scott DG (2002) Evaluation of the Sorensen diagnostic criteria in the classification of systemic vasculitis. Rheumatology (Oxford) 41:1138\u20131141","journal-title":"Rheumatology (Oxford)"},{"key":"436_CR19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00005792-198403000-00001","volume":"63","author":"JG Lanham","year":"1984","unstructured":"Lanham JG, Elkon KB, Pusey CD, Hughes GR (1984) Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore) 63:65\u201381","journal-title":"Medicine (Baltimore)"},{"key":"436_CR20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/ard.2006.054593","volume":"66","author":"R Watts","year":"2007","unstructured":"Watts R et al (2007) Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis 66:222\u2013227","journal-title":"Ann Rheum Dis"},{"key":"436_CR21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/rheumatology\/ken079","volume":"47","author":"LJ Liu","year":"2008","unstructured":"Liu LJ, Chen M, Yu F, Zhao MH, Wang HY (2008) Evaluation of a new algorithm in classification of systemic vasculitis. Rheumatology (Oxford) 47:708\u2013712","journal-title":"Rheumatology (Oxford)"},{"key":"436_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC et al (2013) 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1\u201311","journal-title":"Arthritis Rheum"},{"key":"436_CR23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/1529-0131(200002)43:2<414::AID-ANR23>3.0.CO;2-0","volume":"43","author":"RA Watts","year":"2000","unstructured":"Watts RA, Lane SE, Bentham G, Scott DG (2000) Epidemiology of systemic vasculitis: a ten-year study in the United Kingdom. Arthritis Rheum 43:414\u2013419","journal-title":"Arthritis Rheum"},{"key":"436_CR24","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1136\/ard.60.12.1156a","volume":"60","author":"RA Watts","year":"2001","unstructured":"Watts RA et al (2001) Epidemiology of vasculitis in Europe. Ann Rheum Dis 60:1156\u20131157","journal-title":"Ann Rheum Dis"},{"key":"436_CR25","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1093\/ndt\/gfn354","volume":"23","author":"RA Watts","year":"2008","unstructured":"Watts RA et al (2008) Renal vasculitis in Japan and the UK\u2014are there differences in epidemiology and clinical phenotype? Nephrol Dial Transplant 23:3928\u20133931","journal-title":"Nephrol Dial Transplant"},{"key":"436_CR26","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/rheumatology\/kei259","volume":"45","author":"A Gibson","year":"2006","unstructured":"Gibson A, Stamp LK, Chapman PT, O\u2019Donnell JL (2006) The epidemiology of Wegener\u2019s granulomatosis and microscopic polyangiitis in a Southern Hemisphere region. Rheumatology 45:624\u2013628","journal-title":"Rheumatology"},{"key":"436_CR27","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1177\/153537020422901108","volume":"229","author":"MT Cantorna","year":"2004","unstructured":"Cantorna MT, Mahon BD (2004) Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 229:1136\u20131142","journal-title":"Exp Biol Med"},{"key":"436_CR28","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/rheumatology\/35.2.142","volume":"35","author":"DM Carruthers","year":"1996","unstructured":"Carruthers DM, Watts RA, Symmons DP, Scott DG (1996) Wegener\u2019s granulomatosis\u2014increased incidence or increased recognition? Br J Rheumatol 35:142\u2013145","journal-title":"Br J Rheumatol"},{"key":"436_CR29","first-page":"1524","volume":"20","author":"JP Raynauld","year":"1993","unstructured":"Raynauld JP, Bloch DA, Fries JF (1993) Seasonal variation in the onset of Wegener\u2019s granulomatosis, polyarteritis nodosa and giant cell arteritis. J Rheumatol 20:1524\u20131526","journal-title":"J Rheumatol"},{"key":"436_CR30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2796.1998.00324.x","volume":"244","author":"M Tidman","year":"1998","unstructured":"Tidman M, Olander R, Svalander C, Danielsson D (1998) Patients hospitalized because of small vessel vasculitides with renal involvement in the period 1975\u201395: organ involvement, anti-neutrophil cytoplasmic antibodies patterns, seasonal attack rates and fluctuation of annual frequencies. J Intern Med 244:133\u2013141","journal-title":"J Intern Med"},{"key":"436_CR31","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nm.1874","volume":"14","author":"R Kain","year":"2008","unstructured":"Kain R et al (2008) Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 14:1088\u20131096","journal-title":"Nat Med"},{"key":"436_CR32","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/art.10830","volume":"48","author":"SE Lane","year":"2003","unstructured":"Lane SE, Watts RA, Bentham G, Innes NJ, Scott DG (2003) Are environmental factors important in primary systemic vasculitis? A case-control study. Arthritis Rheum 48:814\u2013823","journal-title":"Arthritis Rheum"},{"key":"436_CR33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2215\/CJN.03501006","volume":"2","author":"SL Hogan","year":"2007","unstructured":"Hogan SL et al (2007) Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study. Clin J Am Soc Nephrol 2:290\u2013299","journal-title":"Clin J Am Soc Nephrol"},{"key":"436_CR34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1681\/ASN.V121134","volume":"12","author":"SL Hogan","year":"2001","unstructured":"Hogan SL et al (2001) Silica exposure in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and lupus nephritis. J Am Soc Nephrol 12:134\u2013142","journal-title":"J Am Soc Nephrol"},{"key":"436_CR35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3200\/AEOH.58.10.662-668","volume":"58","author":"D Pelclova","year":"2003","unstructured":"Pelclova D et al (2003) Asbestos exposure and antineutrophil cytoplasmic antibody (ANCA) positivity. Arch Environ Health 58:662\u2013668","journal-title":"Arch Environ Health"},{"key":"436_CR36","first-page":"669","volume":"16","author":"GF Duna","year":"1998","unstructured":"Duna GF, Cotch MF, Galperin C, Hoffman DB, Hoffman GS (1998) Wegener\u2019s granulomatosis: role of environmental exposures. Clin Exp Rheumatol 16:669\u2013674","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR37","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/art.30590","volume":"63","author":"J Graf","year":"2011","unstructured":"Graf J et al (2011) Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum 63:3998\u20134001","journal-title":"Arthritis Rheum"},{"key":"436_CR38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00002281-199601000-00003","volume":"8","author":"MF Cotch","year":"1996","unstructured":"Cotch MF, Rao JK (1996) New insights into the epidemiology of systemic vasculitis. Curr Opin Rheumatol 8:19\u201325","journal-title":"Curr Opin Rheumatol"},{"key":"436_CR39","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-116-6-488","volume":"116","author":"GS Hoffman","year":"1992","unstructured":"Hoffman GS et al (1992) Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488\u2013498","journal-title":"Ann Intern Med"},{"key":"436_CR40","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1445-5994.2006.01297.x","volume":"37","author":"JL O\u2019Donnell","year":"2007","unstructured":"O\u2019Donnell JL, Stevanovic VR, Frampton C, Stamp LK, Chapman PT (2007) Wegener\u2019s granulomatosis in New Zealand: evidence for a latitude-dependent incidence gradient. Intern Med J 37:242\u2013246","journal-title":"Intern Med J"},{"key":"436_CR41","first-page":"S82","volume":"24","author":"AD Mahr","year":"2006","unstructured":"Mahr AD, Neogi T, Merkel PA (2006) Epidemiology of Wegener\u2019s granulomatosis: lessons from descriptive studies and analyses of genetic and environmental risk determinants. Clin Exp Rheumatol 24:S82\u2013S91","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR42","doi-asserted-by":"crossref","unstructured":"Tanna A, Salama AD, Brookes P, Pusey CD (2012) Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele. BMJ Case Rep 2012","DOI":"10.1136\/bcr.01.2012.5502"},{"key":"436_CR43","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/rheumatology\/kei261","volume":"45","author":"Z Rihova","year":"2006","unstructured":"Rihova Z et al (2006) Two familial cases of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rheumatology 45:356\u2013357","journal-title":"Rheumatology"},{"key":"436_CR44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/art.23157","volume":"58","author":"A Knight","year":"2008","unstructured":"Knight A, Sandin S, Askling J (2008) Risks and relative risks of Wegener\u2019s granulomatosis among close relatives of patients with the disease. Arthritis Rheum 58:302\u2013307","journal-title":"Arthritis Rheum"},{"key":"436_CR45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1399-0039.1989.tb01672.x","volume":"33","author":"A Silman","year":"1989","unstructured":"Silman A, Hennessy E, Ditri M, Ollier W (1989) Co-segregation of HLA and rheumatoid arthritis in multicase families. Tissue Antigens 33:15\u201320","journal-title":"Tissue Antigens"},{"key":"436_CR46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/ard.55.2.89","volume":"55","author":"MA Jones","year":"1996","unstructured":"Jones MA, Silman AJ, Whiting S, Barrett EM, Symmons DP (1996) Occurrence of rheumatoid arthritis is not increased in the first degree relatives of a population based inception cohort of inflammatory polyarthritis. Ann Rheum Dis 55:89\u201393","journal-title":"Ann Rheum Dis"},{"key":"436_CR47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/BOR.0b013e32833654a8","volume":"22","author":"PA Monach","year":"2010","unstructured":"Monach PA, Merkel PA (2010) Genetics of vasculitis. Curr Opin Rheumatol 22:157\u2013163","journal-title":"Curr Opin Rheumatol"},{"key":"436_CR48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/BOR.0b013e3283331151","volume":"22","author":"S Wieczorek","year":"2010","unstructured":"Wieczorek S, Holle JU, Epplen JT (2010) Recent progress in the genetics of Wegener\u2019s granulomatosis and Churg-Strauss syndrome. Curr Opin Rheumatol 22:8\u201314","journal-title":"Curr Opin Rheumatol"},{"key":"436_CR49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/ar2928","volume":"12","author":"LC Willcocks","year":"2010","unstructured":"Willcocks LC, Lyons PA, Rees AJ, Smith KG (2010) The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis. Arthritis Res Ther 12:202","journal-title":"Arthritis Res Ther"},{"key":"436_CR50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJMoa1108735","volume":"367","author":"PA Lyons","year":"2012","unstructured":"Lyons PA et al (2012) Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med 367:214\u2013223","journal-title":"N Engl J Med"},{"key":"436_CR51","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db07-1331","volume":"57","author":"H Erlich","year":"2008","unstructured":"Erlich H et al (2008) HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 57:1084\u20131092","journal-title":"Diabetes"},{"key":"436_CR52","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/rheumatology\/ken247","volume":"47","author":"B Rhodes","year":"2008","unstructured":"Rhodes B, Vyse TJ (2008) The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology 47:1603\u20131611","journal-title":"Rheumatology"},{"key":"436_CR53","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00439-004-1092-z","volume":"114","author":"P Jagiello","year":"2004","unstructured":"Jagiello P et al (2004) New genomic region for Wegener\u2019s granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes. Hum Genet 114:468\u2013477","journal-title":"Hum Genet"},{"key":"436_CR54","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1136\/ard.2007.077693","volume":"67","author":"M Heckmann","year":"2008","unstructured":"Heckmann M et al (2008) The Wegener\u2019s granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping. Ann Rheum Dis 67:972\u2013979","journal-title":"Ann Rheum Dis"},{"key":"436_CR55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/art.23209","volume":"58","author":"S Wieczorek","year":"2008","unstructured":"Wieczorek S, Hellmich B, Gross WL, Epplen JT (2008) Associations of Churg-Strauss syndrome with the HLA-DRB1 locus, and relationship to the genetics of antineutrophil cytoplasmic antibody-associated vasculitides: comment on the article by Vaglio et al. Arthritis Rheum 58:329\u2013330","journal-title":"Arthritis Rheum"},{"key":"436_CR56","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1002\/art.22834","volume":"56","author":"A Vaglio","year":"2007","unstructured":"Vaglio A et al (2007) HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. Arthritis Rheum 56:3159\u20133166","journal-title":"Arthritis Rheum"},{"key":"436_CR57","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/art.38036","volume":"65","author":"G Xie","year":"2013","unstructured":"Xie G et al (2013) Association of granulomatosis with polyangiitis (Wegener\u2019s) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis Rheum 65:2457\u20132468","journal-title":"Arthritis Rheum"},{"key":"436_CR58","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1681\/ASN.2005080882","volume":"17","author":"MD Morgan","year":"2006","unstructured":"Morgan MD, Harper L, Williams J, Savage C (2006) Anti-neutrophil cytoplasm-associated glomerulonephritis. J Am Soc Nephrol JASN 17:1224\u20131234","journal-title":"J Am Soc Nephrol JASN"},{"key":"436_CR59","first-page":"438","volume":"11","author":"ME Griffith","year":"1996","unstructured":"Griffith ME, Lovegrove JU, Gaskin G, Whitehouse DB, Pusey CD (1996) C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Ren Assoc 11:438\u2013443","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Ren Assoc"},{"key":"436_CR60","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2249.1995.tb03652.x","volume":"100","author":"JA Savige","year":"1995","unstructured":"Savige JA et al (1995) Alpha 1-antitrypsin deficiency and anti-proteinase 3 antibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis. Clin Exp Immunol 100:194\u2013197","journal-title":"Clin Exp Immunol"},{"key":"436_CR61","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1365-2362.1996.2070553.x","volume":"26","author":"B Baslund","year":"1996","unstructured":"Baslund B et al (1996) Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener\u2019s granulomatosis. Eur J Clin Investig 26:786\u2013792","journal-title":"Eur J Clin Investig"},{"key":"436_CR62","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/clim.2000.4962","volume":"98","author":"S Borgmann","year":"2001","unstructured":"Borgmann S, Endisch G, Urban S, Sitter T, Fricke H (2001) A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener\u2019s granulomatosis. Clin Immunol 98:244\u2013248","journal-title":"Clin Immunol"},{"key":"436_CR63","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1046\/j.1365-2362.1997.1720717.x","volume":"27","author":"F Callea","year":"1997","unstructured":"Callea F et al (1997) alpha 1-Antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications. Eur J Clin Investig 27:696\u2013702","journal-title":"Eur J Clin Investig"},{"key":"436_CR64","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1042\/cs0870693","volume":"87","author":"K Lhotta","year":"1994","unstructured":"Lhotta K et al (1994) Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis. Clin Sci 87:693\u2013695","journal-title":"Clin Sci"},{"key":"436_CR65","first-page":"39","volume":"16","author":"MA Audrain","year":"2001","unstructured":"Audrain MA et al (2001) Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Ren Assoc 16:39\u201344","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Ren Assoc"},{"key":"436_CR66","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(95)01073-N","volume":"374","author":"L Halbwachs-Mecarelli","year":"1995","unstructured":"Halbwachs-Mecarelli L, Bessou G, Lesavre P, Lopez S, Witko-Sarsat V (1995) Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool. FEBS Lett 374:29\u201333","journal-title":"FEBS Lett"},{"key":"436_CR67","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/01.ASN.0000040751.83734.D1","volume":"14","author":"A Schreiber","year":"2003","unstructured":"Schreiber A, Busjahn A, Luft FC, Kettritz R (2003) Membrane expression of proteinase 3 is genetically determined. J Am Soc Nephrol 14:68\u201375","journal-title":"J Am Soc Nephrol"},{"key":"436_CR68","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1681\/ASN.V1061224","volume":"10","author":"V Witko-Sarsat","year":"1999","unstructured":"Witko-Sarsat V et al (1999) A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J Am Soc Nephrol JASN 10:1224\u20131233","journal-title":"J Am Soc Nephrol JASN"},{"key":"436_CR69","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1097\/01.ASN.0000028642.26222.00","volume":"13","author":"AA Rarok","year":"2002","unstructured":"Rarok AA, Stegeman CA, Limburg PC, Kallenberg CG (2002) Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. J Am Soc Nephrol JASN 13:2232\u20132238","journal-title":"J Am Soc Nephrol JASN"},{"key":"436_CR70","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1046\/j.1523-1755.2000.00430.x","volume":"58","author":"M Gencik","year":"2000","unstructured":"Gencik M, Meller S, Borgmann S, Fricke H (2000) Proteinase 3 gene polymorphisms and Wegener\u2019s granulomatosis. Kidney Int 58:2473\u20132477","journal-title":"Kidney Int"},{"key":"436_CR71","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ng1801","volume":"38","author":"JC Barrett","year":"2006","unstructured":"Barrett JC, Cardon LR (2006) Evaluating coverage of genome-wide association studies. Nat Genet 38:659\u2013662","journal-title":"Nat Genet"},{"key":"436_CR72","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/ard.2007.071936","volume":"67","author":"C Mukhtyar","year":"2008","unstructured":"Mukhtyar C et al (2008) Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League against rheumatism systemic vasculitis task force. Ann Rheum Dis 67:1004\u20131010","journal-title":"Ann Rheum Dis"},{"key":"436_CR73","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1681\/ASN.2010050477","volume":"21","author":"AE Berden","year":"2010","unstructured":"Berden AE et al (2010) Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol JASN 21:1628\u20131636","journal-title":"J Am Soc Nephrol JASN"},{"key":"436_CR74","doi-asserted-by":"crossref","unstructured":"Davies DJ, Moran JE, Niall JF, Ryan GB (1982) Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology? Br Med J (Clin Res Ed) 285(606)","DOI":"10.1136\/bmj.285.6342.606"},{"key":"436_CR75","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1111\/j.1523-1755.2004.00640.x","volume":"65","author":"A Schreiber","year":"2004","unstructured":"Schreiber A, Luft FC, Kettritz R (2004) Membrane proteinase 3 expression and ANCA-induced neutrophil activation. Kidney Int 65:2172\u20132183","journal-title":"Kidney Int"},{"key":"436_CR76","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1073\/pnas.87.11.4115","volume":"87","author":"RJ Falk","year":"1990","unstructured":"Falk RJ, Terrell RS, Charles LA, Jennette JC (1990) Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 87:4115\u20134119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"436_CR77","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jlb.50.6.539","volume":"50","author":"LA Charles","year":"1991","unstructured":"Charles LA, Caldas ML, Falk RJ, Terrell RS, Jennette JC (1991) Antibodies against granule proteins activate neutrophils in vitro. J Leukoc Biol 50:539\u2013546","journal-title":"J Leukoc Biol"},{"key":"436_CR78","first-page":"S35","volume":"22","author":"M Deutsch","year":"2004","unstructured":"Deutsch M et al (2004) Antineutrophil cytoplasmic autoantibodies penetrate into human polymorphonuclear leukocytes and modify their apoptosis. Clin Exp Rheumatol 22:S35\u2013S40","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR79","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1189\/jlb.69.2.177","volume":"69","author":"YM Geld van der","year":"2001","unstructured":"van der Geld YM, Limburg PC, Kallenberg CG (2001) Proteinase 3. Wegener\u2019s autoantigen: from gene to antigen. J Leukoc Biol 69:177\u2013190","journal-title":"J Leukoc Biol"},{"key":"436_CR80","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4049\/jimmunol.153.3.1271","volume":"153","author":"AJ Porges","year":"1994","unstructured":"Porges AJ et al (1994) Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa. J Immunol 153:1271\u20131280","journal-title":"J Immunol"},{"key":"436_CR81","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2249.1994.tb06137.x","volume":"98","author":"AH Mulder","year":"1994","unstructured":"Mulder AH, Heeringa P, Brouwer E, Limburg PC, Kallenberg CG (1994) Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. Clin Exp Immunol 98:270\u2013278","journal-title":"Clin Exp Immunol"},{"key":"436_CR82","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1681\/ASN.V83386","volume":"8","author":"R Kettritz","year":"1997","unstructured":"Kettritz R, Jennette JC, Falk RJ (1997) Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils. J Am Soc Nephrol 8:386\u2013394","journal-title":"J Am Soc Nephrol"},{"key":"436_CR83","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/01.ASN.0000113241.98702.77","volume":"15","author":"P Hewins","year":"2004","unstructured":"Hewins P, Williams JM, Wakelam MJ, Savage CO (2004) Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fc gamma receptors and CD18. J Am Soc Nephrol 15:796\u2013808","journal-title":"J Am Soc Nephrol"},{"key":"436_CR84","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/01.ASN.0000050223.34749.F4","volume":"14","author":"JM Williams","year":"2003","unstructured":"Williams JM et al (2003) Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab\u2032)2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. J Am Soc Nephrol 14:661\u2013669","journal-title":"J Am Soc Nephrol"},{"key":"436_CR85","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0002-9440(10)64000-X","volume":"158","author":"JJ Yang","year":"2001","unstructured":"Yang JJ et al (2001) Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. Am J Pathol 158:581\u2013592","journal-title":"Am J Pathol"},{"key":"436_CR86","first-page":"335","volume":"141","author":"CO Savage","year":"1992","unstructured":"Savage CO, Pottinger BE, Gaskin G, Pusey CD, Pearson JD (1992) Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells. Am J Pathol 141:335\u2013342","journal-title":"Am J Pathol"},{"key":"436_CR87","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/1529-0131(200006)43:6<1337::AID-ANR16>3.0.CO;2-M","volume":"43","author":"DJ Radford","year":"2000","unstructured":"Radford DJ, Savage CO, Nash GB (2000) Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin-mediated adhesion. Arthritis Rheum 43:1337\u20131345","journal-title":"Arthritis Rheum"},{"key":"436_CR88","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1681\/ASN.2005101048","volume":"17","author":"JC Jennette","year":"2006","unstructured":"Jennette JC, Xiao H, Falk RJ (2006) Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 17:1235\u20131242","journal-title":"J Am Soc Nephrol"},{"key":"436_CR89","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/ar1805","volume":"7","author":"A Wiik","year":"2005","unstructured":"Wiik A (2005) Clinical and laboratory characteristics of drug-induced vasculitic syndromes. Arthritis Res Ther 7:191\u2013192","journal-title":"Arthritis Res Ther"},{"key":"436_CR90","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/art.24637","volume":"60","author":"RB Jones","year":"2009","unstructured":"Jones RB et al (2009) A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 60:2156\u20132168","journal-title":"Arthritis Rheum"},{"key":"436_CR91","doi-asserted-by":"crossref","first-page":"846063","DOI":"10.1155\/2010\/846063","volume":"2010","author":"A Khan","year":"2010","unstructured":"Khan A, Lawson CA, Quinn MA, Isdale AH, Green MJ (2010) Successful treatment of ANCA-negative Wegener\u2019s granulomatosis with rituximab. Int J Rheumatol 2010:846063","journal-title":"Int J Rheumatol"},{"key":"436_CR92","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1081-1206(10)61400-7","volume":"93","author":"PJ Bansal","year":"2004","unstructured":"Bansal PJ, Tobin MC (2004) Neonatal microscopic polyangiitis secondary to transfer of maternal myeloperoxidase-antineutrophil cytoplasmic antibody resulting in neonatal pulmonary hemorrhage and renal involvement. Ann Allergy Asthma Immunol 93:398\u2013401","journal-title":"Ann Allergy Asthma Immunol"},{"key":"436_CR93","doi-asserted-by":"crossref","first-page":"e28626","DOI":"10.1371\/journal.pone.0028626","volume":"7","author":"MA Little","year":"2012","unstructured":"Little MA et al (2012) Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system. PLoS One 7:e28626","journal-title":"PLoS One"},{"key":"436_CR94","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI0215918","volume":"110","author":"H Xiao","year":"2002","unstructured":"Xiao H et al (2002) Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 110:955\u2013963","journal-title":"J Clin Invest"},{"key":"436_CR95","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0002-9440(10)62951-3","volume":"167","author":"H Xiao","year":"2005","unstructured":"Xiao H et al (2005) The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 167:39\u201345","journal-title":"Am J Pathol"},{"key":"436_CR96","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1182\/blood-2004-01-0267","volume":"104","author":"H Pfister","year":"2004","unstructured":"Pfister H et al (2004) Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo. Blood 104:1411\u20131418","journal-title":"Blood"},{"key":"436_CR97","doi-asserted-by":"crossref","unstructured":"Primo VC et al Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clin Exp Immunol 159:327\u2013337","DOI":"10.1111\/j.1365-2249.2009.04072.x"},{"key":"436_CR98","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2249.2004.02575.x","volume":"138","author":"K Andersen-Ranberg","year":"2004","unstructured":"Andersen-Ranberg K, H\u00d8ier-Madsen M, Wiik A, Jeune B, Hegedus L (2004) High prevalence of autoantibodies among Danish centenarians. Clin Exp Immunol 138:158\u2013163","journal-title":"Clin Exp Immunol"},{"key":"436_CR99","first-page":"826","volume":"27","author":"N Seta","year":"2009","unstructured":"Seta N, Kobayashi S, Hashimoto H, Kuwana M (2009) Characterization of autoreactive T-cell clones to myeloperoxidase in patients with microscopic polyangiitis and healthy individuals. Clin Exp Rheumatol 27:826\u2013829","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR100","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2353\/ajpath.2007.060573","volume":"170","author":"H Xiao","year":"2007","unstructured":"Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC (2007) Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol 170:52\u201364","journal-title":"Am J Pathol"},{"key":"436_CR101","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/sj.ki.5002103","volume":"71","author":"D Huugen","year":"2007","unstructured":"Huugen D et al (2007) Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int 71:646\u2013654","journal-title":"Kidney Int"},{"key":"436_CR102","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s10875-008-9268-2","volume":"29","author":"GQ Xing","year":"2009","unstructured":"Xing GQ et al (2009) Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis. J Clin Immunol 29:282\u2013291","journal-title":"J Clin Immunol"},{"key":"436_CR103","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10875-009-9344-2","volume":"30","author":"GQ Xing","year":"2010","unstructured":"Xing GQ et al (2010) Differential deposition of C4d and MBL in glomeruli of patients with ANCA-negative pauci-immune crescentic glomerulonephritis. J Clin Immunol 30:144\u2013156","journal-title":"J Clin Immunol"},{"key":"436_CR104","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ki.2012.313","volume":"83","author":"SJ Gou","year":"2013","unstructured":"Gou SJ, Yuan J, Chen M, Yu F, Zhao MH (2013) Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis. Kidney Int 83:129\u2013137","journal-title":"Kidney Int"},{"key":"436_CR105","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1182\/blood-2010-05-283564","volume":"117","author":"L Camous","year":"2011","unstructured":"Camous L et al (2011) Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood 117:1340\u20131349","journal-title":"Blood"},{"key":"436_CR106","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1681\/ASN.2008050497","volume":"20","author":"A Schreiber","year":"2009","unstructured":"Schreiber A et al (2009) C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis. J Am Soc Nephrol 20:289\u2013298","journal-title":"J Am Soc Nephrol"},{"key":"436_CR107","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/17402520600578731","volume":"13","author":"R Root-Bernstein","year":"2006","unstructured":"Root-Bernstein R, Couturier J (2006) Antigenic complementarity in the origins of autoimmunity: a general theory illustrated with a case study of idiopathic thrombocytopenia purpura. Clin Dev Immunol 13:49\u201365","journal-title":"Clin Dev Immunol"},{"key":"436_CR108","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nm968","volume":"10","author":"WF Pendergraft 3rd","year":"2004","unstructured":"Pendergraft WF 3rd et al (2004) Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat Med 10:72\u201379","journal-title":"Nat Med"},{"key":"436_CR109","doi-asserted-by":"crossref","first-page":"e17972","DOI":"10.1371\/journal.pone.0017972","volume":"6","author":"H Tadema","year":"2011","unstructured":"Tadema H, Kallenberg CG, Stegeman CA, Heeringa P (2011) Reactivity against complementary proteinase-3 is not increased in patients with PR3-ANCA-associated vasculitis. PLoS One 6:e17972","journal-title":"PLoS One"},{"key":"436_CR110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nbt808","volume":"21","author":"R Yelin","year":"2003","unstructured":"Yelin R et al (2003) Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 21:379\u2013386","journal-title":"Nat Biotechnol"},{"key":"436_CR111","first-page":"783","volume":"20","author":"J Savige","year":"2002","unstructured":"Savige J et al (2002) Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis after immunisation with bacterial proteins. Clin Exp Rheumatol 20:783\u2013789","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR112","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7326\/0003-4819-120-1-199401010-00003","volume":"120","author":"CA Stegeman","year":"1994","unstructured":"Stegeman CA et al (1994) Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis. Ann Intern Med 120:12\u201317","journal-title":"Ann Intern Med"},{"key":"436_CR113","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1056\/NEJM199607043350103","volume":"335","author":"CA Stegeman","year":"1996","unstructured":"Stegeman CA, Tervaert JW, de Jong PE, Kallenberg CG (1996) Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener\u2019s granulomatosis. Dutch Co-Trimoxazole Wegener Study Group. N Engl J Med 335:16\u201320","journal-title":"N Engl J Med"},{"key":"436_CR114","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.181.2.585","volume":"181","author":"R Kain","year":"1995","unstructured":"Kain R et al (1995) A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 181:585\u2013597","journal-title":"J Exp Med"},{"key":"436_CR115","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1083\/jcb.137.5.1161","volume":"137","author":"NR Gough","year":"1997","unstructured":"Gough NR, Fambrough DM (1997) Different steady state subcellular distributions of the three splice variants of lysosome-associated membrane protein LAMP-2 are determined largely by the COOH-terminal amino acid residue. J Cell Biol 137:1161\u20131169","journal-title":"J Cell Biol"},{"key":"436_CR116","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/BOR.0b013e32835b4f8f","volume":"25","author":"R Kain","year":"2013","unstructured":"Kain R, Rees AJ (2013) What is the evidence for antibodies to LAMP-2 in the pathogenesis of ANCA associated small vessel vasculitis? Curr Opin Rheumatol 25:26\u201334","journal-title":"Curr Opin Rheumatol"},{"key":"436_CR117","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1681\/ASN.2011090920","volume":"23","author":"R Kain","year":"2012","unstructured":"Kain R et al (2012) High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis. J Am Soc Nephrol 23:556\u2013566","journal-title":"J Am Soc Nephrol"},{"key":"436_CR118","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2011030273","volume":"23","author":"AJ Roth","year":"2012","unstructured":"Roth AJ et al (2012) Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody glomerulonephritis. J Am Soc Nephrol 23:545\u2013555","journal-title":"J Am Soc Nephrol"},{"key":"436_CR119","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V et al (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532\u20131535","journal-title":"Science"},{"key":"436_CR120","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","volume":"15","author":"K Kessenbrock","year":"2009","unstructured":"Kessenbrock K et al (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15:623\u2013625","journal-title":"Nat Med"},{"key":"436_CR121","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2012-03-416156","volume":"120","author":"S Sangaletti","year":"2012","unstructured":"Sangaletti S et al (2012) Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120:3007\u20133018","journal-title":"Blood"},{"key":"436_CR122","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","volume":"176","author":"TA Fuchs","year":"2007","unstructured":"Fuchs TA et al (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176:231\u2013241","journal-title":"J Cell Biol"},{"key":"436_CR123","first-page":"S49","volume":"25","author":"P Lamprecht","year":"2007","unstructured":"Lamprecht P (2007) Current knowledge on cellular interactions in the WG granuloma. Clin Exp Rheumatol 25:S49\u2013S51","journal-title":"Clin Exp Rheumatol"},{"key":"436_CR124","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0046-8177(88)80088-1","volume":"19","author":"EJ Mark","year":"1988","unstructured":"Mark EJ, Matsubara O, Tan-Liu NS, Fienberg R (1988) The pulmonary biopsy in the early diagnosis of Wegener\u2019s (pathergic) granulomatosis: a study based on 35 open lung biopsies. Hum Pathol 19:1065\u20131071","journal-title":"Hum Pathol"},{"key":"436_CR125","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0002-9343(83)91030-6","volume":"74","author":"GN Gephardt","year":"1983","unstructured":"Gephardt GN, Ahmad M, Tubbs RR (1983) Pulmonary vasculitis (Wegener\u2019s granulomatosis). Immunohistochemical study of T and B cell markers. Am J Med 74:700\u2013704","journal-title":"Am J Med"},{"key":"436_CR126","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/ar96","volume":"2","author":"A Wiik","year":"2000","unstructured":"Wiik A (2000) What you should know about PR3-ANCA. An introduction. Arthritis Res 2:252\u2013254","journal-title":"Arthritis Res"},{"key":"436_CR127","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1182\/blood-2005-05-1875","volume":"107","author":"E Csernok","year":"2006","unstructured":"Csernok E et al (2006) Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107:4440\u20134448","journal-title":"Blood"},{"key":"436_CR128","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clim.2007.12.004","volume":"127","author":"D Capraru","year":"2008","unstructured":"Capraru D et al (2008) Expansion of circulating NKG2D\u2009+\u2009effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener\u2019s granulomatosis. Clin Immunol 127:144\u2013150","journal-title":"Clin Immunol"},{"key":"436_CR129","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/rheumatology\/ken202","volume":"47","author":"A Mueller","year":"2008","unstructured":"Mueller A, Holl-Ulrich K, Lamprecht P, Gross WL (2008) Germinal centre-like structures in Wegener\u2019s granuloma: the morphological basis for autoimmunity? Rheumatology (Oxford) 47:1111\u20131113","journal-title":"Rheumatology (Oxford)"},{"key":"436_CR130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/ard.2005.044909","volume":"65","author":"J Voswinkel","year":"2006","unstructured":"Voswinkel J et al (2006) B lymphocyte maturation in Wegener\u2019s granulomatosis: a comparative analysis of VH genes from endonasal lesions. Ann Rheum Dis 65:859\u2013864","journal-title":"Ann Rheum Dis"},{"key":"436_CR131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2249.1991.tb05647.x","volume":"83","author":"E Brouwer","year":"1991","unstructured":"Brouwer E et al (1991) Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener\u2019s granulomatosis and clinically related disorders. Clin Exp Immunol 83:379\u2013386","journal-title":"Clin Exp Immunol"},{"key":"436_CR132","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2249.2005.02731.x","volume":"140","author":"S Marinaki","year":"2005","unstructured":"Marinaki S et al (2005) Abnormalities of CD4 T cell subpopulations in ANCA-associated vasculitis. Clin Exp Immunol 140:181\u2013191","journal-title":"Clin Exp Immunol"},{"key":"436_CR133","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/art.22692","volume":"56","author":"WH Abdulahad","year":"2007","unstructured":"Abdulahad WH et al (2007) Functional defect of circulating regulatory CD4+ T cells in patients with Wegener\u2019s granulomatosis in remission. Arthritis Rheum 56:2080\u20132091","journal-title":"Arthritis Rheum"},{"key":"436_CR134","first-page":"435","volume":"54","author":"M Christensson","year":"2000","unstructured":"Christensson M, Pettersson E, Sundqvist KG, Christensson B (2000) T cell activation in patients with ANCA-associated vasculitis: inefficient immune suppression by therapy. Clin Nephrol 54:435\u2013442","journal-title":"Clin Nephrol"},{"key":"436_CR135","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1023\/A:1023230722874","volume":"18","author":"R Giscombe","year":"1998","unstructured":"Giscombe R, Nityanand S, Lewin N, Grunewald J, Lefvert AK (1998) Expanded T cell populations in patients with Wegener\u2019s granulomatosis: characteristics and correlates with disease activity. J Clin Immunol 18:404\u2013413","journal-title":"J Clin Immunol"},{"key":"436_CR136","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2796.2006.01688.x","volume":"260","author":"R Giscombe","year":"2006","unstructured":"Giscombe R, Wang XB, Kakoulidou M, Lefvert AK (2006) Characterization of the expanded T-cell populations in patients with Wegener\u2019s granulomatosis. J Intern Med 260:224\u2013230","journal-title":"J Intern Med"},{"key":"436_CR137","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/ndt\/gfl097","volume":"21","author":"S Marinaki","year":"2006","unstructured":"Marinaki S et al (2006) Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitis. Nephrol Dial Transplant 21:1825\u20131832","journal-title":"Nephrol Dial Transplant"},{"key":"436_CR138","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2350-10-22","volume":"10","author":"EJ Carr","year":"2009","unstructured":"Carr EJ et al (2009) Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Med Genet 10:22","journal-title":"BMC Med Genet"},{"key":"436_CR139","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.autrev.2004.06.003","volume":"4","author":"P Jagiello","year":"2005","unstructured":"Jagiello P, Gross WL, Epplen JT (2005) Complex genetics of Wegener granulomatosis. Autoimmun Rev 4:42\u201347","journal-title":"Autoimmun Rev"},{"key":"436_CR140","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/sj.ki.5001670","volume":"70","author":"WH Abdulahad","year":"2006","unstructured":"Abdulahad WH, van der Geld YM, Stegeman CA, Kallenberg CG (2006) Persistent expansion of CD4+ effector memory T cells in Wegener\u2019s granulomatosis. Kidney Int 70:938\u2013947","journal-title":"Kidney Int"},{"key":"436_CR141","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","volume":"133","author":"S Sakaguchi","year":"2008","unstructured":"Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775\u2013787","journal-title":"Cell"},{"key":"436_CR142","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/art.1780350914","volume":"35","author":"WH Schmitt","year":"1992","unstructured":"Schmitt WH, Heesen C, Csernok E, Rautmann A, Gross WL (1992) Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener\u2019s granulomatosis. Association with disease activity. Arthritis Rheum 35:1088\u20131096","journal-title":"Arthritis Rheum"},{"key":"436_CR143","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.1993.tb05918.x","volume":"91","author":"CA Stegeman","year":"1993","unstructured":"Stegeman CA, Tervaert JW, Huitema MG, Kallenberg CG (1993) Serum markers of T cell activation in relapses of Wegener\u2019s granulomatosis. Clin Exp Immunol 91:415\u2013420","journal-title":"Clin Exp Immunol"},{"key":"436_CR144","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/art.23557","volume":"58","author":"WH Abdulahad","year":"2008","unstructured":"Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG (2008) Skewed distribution of Th17 lymphocytes in patients with Wegener\u2019s granulomatosis in remission. Arthritis Rheum 58:2196\u20132205","journal-title":"Arthritis Rheum"},{"key":"436_CR145","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/art.24747","volume":"60","author":"WH Abdulahad","year":"2009","unstructured":"Abdulahad WH, Kallenberg CG, Limburg PC, Stegeman CA (2009) Urinary CD4+ effector memory T cells reflect renal disease activity in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 60:2830\u20132838","journal-title":"Arthritis Rheum"},{"key":"436_CR146","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/rheumatology\/ken028","volume":"47","author":"C Iking-Konert","year":"2008","unstructured":"Iking-Konert C et al (2008) T lymphocytes in patients with primary vasculitis: expansion of CD8+ T cells with the propensity to activate polymorphonuclear neutrophils. Rheumatology (Oxford) 47:609\u2013616","journal-title":"Rheumatology (Oxford)"},{"key":"436_CR147","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-1759(97)00082-3","volume":"206","author":"L Stummann","year":"1997","unstructured":"Stummann L, Wiik A (1997) A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA. J Immunol Methods 206:35\u201342","journal-title":"J Immunol Methods"},{"key":"436_CR148","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ki.1994.149","volume":"45","author":"E Brouwer","year":"1994","unstructured":"Brouwer E et al (1994) Neutrophil activation in vitro and in vivo in Wegener\u2019s granulomatosis. Kidney Int 45:1120\u20131131","journal-title":"Kidney Int"},{"key":"436_CR149","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2249.1995.tb03651.x","volume":"100","author":"BE Ballieux","year":"1995","unstructured":"Ballieux BE et al (1995) Cell-mediated autoimmunity in patients with Wegener\u2019s granulomatosis (WG). Clin Exp Immunol 100:186\u2013193","journal-title":"Clin Exp Immunol"},{"key":"436_CR150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-2249.1998.00615.x","volume":"112","author":"WJ King","year":"1998","unstructured":"King WJ et al (1998) T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission. Clin Exp Immunol 112:539\u2013546","journal-title":"Clin Exp Immunol"},{"key":"436_CR151","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0090-1229(92)90005-9","volume":"63","author":"PW Mathieson","year":"1992","unstructured":"Mathieson PW, Lockwood CM, Oliveira DB (1992) T and B cell responses to neutrophil cytoplasmic antigens in systemic vasculitis. Clin Immunol Immunopathol 63:135\u2013141","journal-title":"Clin Immunol Immunopathol"},{"key":"436_CR152","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/art.10384","volume":"46","author":"ER Popa","year":"2002","unstructured":"Popa ER et al (2002) In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase. Arthritis Rheum 46:1894\u20131904","journal-title":"Arthritis Rheum"},{"key":"436_CR153","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1365-2249.1996.d01-629.x","volume":"103","author":"ME Griffith","year":"1996","unstructured":"Griffith ME, Coulthart A, Pusey CD (1996) T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis. Clin Exp Immunol 103:253\u2013258","journal-title":"Clin Exp Immunol"},{"key":"436_CR154","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/s10165-008-0109-1","volume":"18","author":"N Seta","year":"2008","unstructured":"Seta N et al (2008) Autoreactive T-cell responses to myeloperoxidase in patients with antineutrophil cytoplasmic antibody-associated vasculitis and in healthy individuals. Mod Rheumatol 18:593\u2013600","journal-title":"Mod Rheumatol"},{"key":"436_CR155","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1182\/blood.V92.10.3737","volume":"92","author":"J Grunewald","year":"1998","unstructured":"Grunewald J et al (1998) T-cell expansions with conserved T-cell receptor beta chain motifs in the peripheral blood of HLA-DRB1*0401 positive patients with necrotizing vasculitis. Blood 92:3737\u20133744","journal-title":"Blood"},{"key":"436_CR156","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-065X.2008.00681.x","volume":"225","author":"JD Fraser","year":"2008","unstructured":"Fraser JD, Proft T (2008) The bacterial superantigen and superantigen-like proteins. Immunol Rev 225:226\u2013243","journal-title":"Immunol Rev"},{"key":"436_CR157","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1046\/j.1365-2249.2003.02157.x","volume":"132","author":"ER Popa","year":"2003","unstructured":"Popa ER, Stegeman CA, Bos NA, Kallenberg CG, Tervaert JW (2003) Staphylococcal superantigens and T cell expansions in Wegener\u2019s granulomatosis. Clin Exp Immunol 132:496\u2013504","journal-title":"Clin Exp Immunol"},{"key":"436_CR158","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bmj.2.5091.265","volume":"2","author":"EW Walton","year":"1958","unstructured":"Walton EW (1958) Giant-cell granuloma of the respiratory tract (Wegener\u2019s granulomatosis). Br Med J 2:265\u2013270","journal-title":"Br Med J"},{"key":"436_CR159","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0272-6386(03)00025-8","volume":"41","author":"AD Booth","year":"2003","unstructured":"Booth AD et al (2003) Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study. Am J Kidney Dis 41:776\u2013784","journal-title":"Am J Kidney Dis"},{"key":"436_CR160","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.2010.137778","volume":"70","author":"O Flossmann","year":"2011","unstructured":"Flossmann O et al (2011) Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis 70:488\u2013494","journal-title":"Ann Rheum Dis"},{"key":"436_CR161","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/ard.2009.109389","volume":"69","author":"MA Little","year":"2010","unstructured":"Little MA et al (2010) Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis. Ann Rheum Dis 69:1036\u20131043","journal-title":"Ann Rheum Dis"},{"key":"436_CR162","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ndt\/gfg551","volume":"19","author":"MA Little","year":"2004","unstructured":"Little MA, Nazar L, Farrington K (2004) Outcome in glomerulonephritis due to systemic small vessel vasculitis: effect of functional status and non-vasculitic co-morbidity. Nephrol Dial Transplant 19:356\u2013364","journal-title":"Nephrol Dial Transplant"},{"key":"436_CR163","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/art.33361","volume":"64","author":"M Walsh","year":"2012","unstructured":"Walsh M et al (2012) Risk factors for relapse of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 64:542\u2013548","journal-title":"Arthritis Rheum"},{"key":"436_CR164","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncprheum0042","volume":"2","author":"R Eisenberg","year":"2006","unstructured":"Eisenberg R, Albert D (2006) B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus. Nat Clin Pract Rheumatol 2:20\u201327","journal-title":"Nat Clin Pract Rheumatol"},{"key":"436_CR165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ncprheum0424","volume":"3","author":"RP Taylor","year":"2007","unstructured":"Taylor RP, Lindorfer MA (2007) Drug insight: the mechanism of action of rituximab in autoimmune disease\u2014the immune complex decoy hypothesis. Nat Clin Pract Rheumatol 3:86\u201395","journal-title":"Nat Clin Pract Rheumatol"},{"key":"436_CR166","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa0909905","volume":"363","author":"JH Stone","year":"2010","unstructured":"Stone JH et al (2010) Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 363:221\u2013232","journal-title":"N Engl J Med"},{"key":"436_CR167","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1056\/NEJMoa1213277","volume":"369","author":"U Specks","year":"2013","unstructured":"Specks U, Ikle D, Stone JH (2013) Induction regimens for ANCA-associated vasculitis. N Engl J Med 369:1865\u20131866","journal-title":"N Engl J Med"},{"key":"436_CR168","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1002\/art.34583","volume":"64","author":"RM Smith","year":"2012","unstructured":"Smith RM et al (2012) Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 64:3760\u20133769","journal-title":"Arthritis Rheum"},{"key":"436_CR169","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/rheumatology\/ket257","volume":"52","author":"E Besada","year":"2013","unstructured":"Besada E, Koldingsnes W, Nossent JC (2013) Long-term efficacy and safety of pre-emptive maintenance therapy with rituximab in granulomatosis with polyangiitis: results from a single centre. Rheumatology 52:2041\u20132047","journal-title":"Rheumatology"},{"key":"436_CR170","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/ard.2007.081661","volume":"67","author":"M Walsh","year":"2008","unstructured":"Walsh M, Chaudhry A, Jayne D (2008) Long-term follow-up of relapsing\/refractory anti-neutrophil cytoplasm antibody associated vasculitis treated with the lymphocyte depleting antibody alemtuzumab (CAMPATH-1H). Ann Rheum Dis 67:1322\u20131327","journal-title":"Ann Rheum Dis"},{"key":"436_CR171","doi-asserted-by":"crossref","unstructured":"Langford CA et al (2013) An open-label trial of abatacept (CTLA4-IG) in non-severe relapsing granulomatosis with polyangiitis (Wegener\u2019s). Ann Rheum Dis","DOI":"10.1136\/annrheumdis-2013-204164"},{"key":"436_CR172","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nm.2130","volume":"16","author":"EF McKinney","year":"2010","unstructured":"McKinney EF et al (2010) A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nat Med 16:586\u2013591","journal-title":"Nat Med"},{"key":"436_CR173","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1172\/JCI59255","volume":"121","author":"JC Lee","year":"2011","unstructured":"Lee JC et al (2011) Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. J Clin Invest 121:4170\u20134179","journal-title":"J Clin Invest"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00281-014-0436-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-014-0436-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-014-0436-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T12:19:03Z","timestamp":1689423543000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00281-014-0436-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":173,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["436"],"URL":"https:\/\/doi.org\/10.1007\/s00281-014-0436-6","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}