{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:58:18Z","timestamp":1791291498802,"version":"4.3.0"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00281-015-0505-5","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T12:50:57Z","timestamp":1436273457000},"page":"489-500","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Vasculopathy in scleroderma"],"prefix":"10.1007","volume":"37","author":[{"given":"Yoshihide","family":"Asano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,8]]},"reference":[{"issue":"Suppl 3","key":"505_CR1","first-page":"iii3","volume":"48","author":"DJ Abraham","year":"2009","unstructured":"Abraham DJ, Krieg T, Distler J, Distler O (2009) Overview of pathogenesis of systemic sclerosis. Rheumatology (Oxford) 48(Suppl 3):iii3\u2013iii7","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1346-8138.2009.00758.x","volume":"37","author":"Y Asano","year":"2010","unstructured":"Asano Y (2010) Future treatments in systemic sclerosis. J Dermatol 37:54\u201370","journal-title":"J Dermatol"},{"key":"505_CR3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrrheum.2014.128","volume":"10","author":"JC Broen","year":"2014","unstructured":"Broen JC, Radstake TR, Rossato M (2014) The role of genetics and epigenetics in the pathogenesis of systemic sclerosis. Nat Rev Rheumatol 10:671\u2013681","journal-title":"Nat Rev Rheumatol"},{"key":"505_CR4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1711660307","volume":"166","author":"RJ Prescott","year":"1992","unstructured":"Prescott RJ, Freemont AJ, Jones CJ, Hoyland J, Fielding P (1992) Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol 166:255\u2013263","journal-title":"J Pathol"},{"key":"505_CR5","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI118851","volume":"98","author":"R Sgonc","year":"1996","unstructured":"Sgonc R, Gruschwitz MS, Dietrich H, Recheis H, Gershwin ME, Wick G (1996) Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Investig 98:785\u2013792","journal-title":"J Clin Investig"},{"key":"505_CR6","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/ard.2004.027094","volume":"64","author":"A Kalogerou","year":"2005","unstructured":"Kalogerou A, Gelou E, Mountantonakis S, Settas L, Zafiriou E, Sakkas L (2005) Early T cell activation in the skin from patients with systemic sclerosis. Ann Rheum Dis 64:1233\u20131235","journal-title":"Ann Rheum Dis"},{"key":"505_CR7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11926-005-0069-9","volume":"7","author":"H Ihn","year":"2005","unstructured":"Ihn H (2005) Scleroderma, fibroblasts, signaling, and excessive extracellular matrix. Curr Rheumatol Rep 7:156\u2013162","journal-title":"Curr Rheumatol Rep"},{"issue":"Suppl 3","key":"505_CR8","first-page":"iii26","volume":"45","author":"JH Distler","year":"2006","unstructured":"Distler JH, Gay S, Distler O (2006) Angiogenesis and vasculogenesis in systemic sclerosis. Rheumatology (Oxford) 45(Suppl 3):iii26\u2013iii27","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(04)16853-0","volume":"364","author":"M Kuwana","year":"2004","unstructured":"Kuwana M, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y (2004) Defective vasculogenesis in systemic sclerosis. Lancet 364:603\u2013610","journal-title":"Lancet"},{"key":"505_CR10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11926-011-0219-1","volume":"14","author":"BJ Rabquer","year":"2012","unstructured":"Rabquer BJ, Koch AE (2012) Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts. Curr Rheumatol Rep 14:56\u201363","journal-title":"Curr Rheumatol Rep"},{"key":"505_CR11","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T (2009) Scleroderma. N Engl J Med 360:1989\u20132003","journal-title":"N Engl J Med"},{"key":"505_CR12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/14397595.2013.854064","volume":"24","author":"T Takahashi","year":"2014","unstructured":"Takahashi T, Asano Y, Amiya E, Hatano M, Tamaki Z, Takata M et al (2014) Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis. Mod Rheumatol 24:106\u2013111","journal-title":"Mod Rheumatol"},{"key":"505_CR13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/sarh.2002.50011","volume":"32","author":"MM Cerinic","year":"2003","unstructured":"Cerinic MM, Valentini G, Sorano GG, D\u2019Angelo S, Cuomo G, Fenu L et al (2003) Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis. Semin Arthritis Rheum 32:285\u2013295","journal-title":"Semin Arthritis Rheum"},{"key":"505_CR14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/art.38948","volume":"67","author":"T Taniguchi","year":"2015","unstructured":"Taniguchi T, Asano Y, Akamata K, Noda S, Takahashi T, Ichimura Y et al (2015) Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Arthr Rheumatol 67:517\u2013526","journal-title":"Arthr Rheumatol"},{"key":"505_CR15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jdermsci.2007.05.014","volume":"49","author":"H Ihn","year":"2008","unstructured":"Ihn H (2008) Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis. J Dermatol Sci 49:103\u2013113","journal-title":"J Dermatol Sci"},{"key":"505_CR16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajpath.2012.09.007","volume":"182","author":"S Bhattacharyya","year":"2013","unstructured":"Bhattacharyya S, Kelley K, Melichian DS, Tamaki Z, Fang F, Su Y et al (2013) Toll-like receptor 4 signaling augments transforming growth factor-\u03b2 responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 182:192\u2013205","journal-title":"Am J Pathol"},{"key":"505_CR17","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.21948","volume":"54","author":"Y Wang","year":"2006","unstructured":"Wang Y, Fan PS, Kahaleh B (2006) Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54:2271\u20132279","journal-title":"Arthritis Rheum"},{"key":"505_CR18","first-page":"1751","volume":"151","author":"C Mavalia","year":"1997","unstructured":"Mavalia C, Scaletti C, Romagnani P, Carossino AM, Pignone A, Emmi L et al (1997) Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis. Am J Pathol 151:1751\u20131758","journal-title":"Am J Pathol"},{"key":"505_CR19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/1529-0131(199802)41:2<327::AID-ART17>3.0.CO;2-S","volume":"41","author":"R Giacomelli","year":"1998","unstructured":"Giacomelli R, Matucci-Cerinic M, Cipriani P, Ghersetich I, Lattanzio R, Pavan A et al (1998) Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients. Arthritis Rheum 41:327\u2013334","journal-title":"Arthritis Rheum"},{"key":"505_CR20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/clim.1999.4694","volume":"91","author":"MB Kahaleh","year":"1999","unstructured":"Kahaleh MB, Fan PS, Otsuka T (1999) Gammadelta receptor bearing T cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro. Clin Immunol 91:188\u2013195","journal-title":"Clin Immunol"},{"key":"505_CR21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2249.1996.d01-867.x","volume":"106","author":"MB Hill","year":"1996","unstructured":"Hill MB, Phipps JL, Cartwright RJ, Milford Ward A, Greaves M, Hughes P (1996) Antibodies to membranes of endothelial cells and fibroblasts in scleroderma. Clin Exp Immunol 106:491\u2013497","journal-title":"Clin Exp Immunol"},{"key":"505_CR22","first-page":"450","volume":"72","author":"J Rosenbaum","year":"1988","unstructured":"Rosenbaum J, Pottinger BE, Woo P, Black CM, Loizou S, Byron MA et al (1988) Measurement and characterisation of circulating anti-endothelial cell IgG in connective tissue diseases. Clin Exp Immunol 72:450\u2013456","journal-title":"Clin Exp Immunol"},{"key":"505_CR23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0002-9343(96)00404-4","volume":"102","author":"KV Salojin","year":"1997","unstructured":"Salojin KV, Le Tonqu\u00e8ze M, Saraux A, Nassonov EL, Dueymes M, Piette JC et al (1997) Antiendothelial cell antibodies: useful markers of systemic sclerosis. Am J Med 102:178\u2013185","journal-title":"Am J Med"},{"key":"505_CR24","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/1529-0131(200011)43:11<2550::AID-ANR24>3.0.CO;2-H","volume":"43","author":"R Sgonc","year":"2000","unstructured":"Sgonc R, Gruschwitz MS, Boeck G, Sepp N, Gruber J, Wick G (2000) Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum 43:2550\u20132562","journal-title":"Arthritis Rheum"},{"key":"505_CR25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/ard.2008.102400","volume":"69","author":"C Mihai","year":"2010","unstructured":"Mihai C, Tervaert JW (2010) Anti-endothelial cell antibodies in systemic sclerosis. Ann Rheum Dis 69:319\u2013324","journal-title":"Ann Rheum Dis"},{"key":"505_CR26","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/CIRCRESAHA.113.301078","volume":"112","author":"C Park","year":"2013","unstructured":"Park C, Kim TM, Malik AB (2013) Transcriptional regulation of endothelial cell and vascular development. Circ Res 112:1380\u20131400","journal-title":"Circ Res"},{"key":"505_CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/3-540-36028-X_6","volume":"176","author":"C Fischer","year":"2006","unstructured":"Fischer C, Schneider M, Carmeliet P (2006) Principles and therapeutic implications of angiogenesis, vasculogenesis and arteriogenesis. Handb Exp Pharmacol 176:157\u2013212","journal-title":"Handb Exp Pharmacol"},{"key":"505_CR28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1172\/JCI200524283","volume":"115","author":"S Dimmeler","year":"2005","unstructured":"Dimmeler S, Zeiher AM, Schneider MD (2005) Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest 115:572\u2013583","journal-title":"J Clin Invest"},{"key":"505_CR29","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/sj.leu.2404676","volume":"21","author":"DN Prater","year":"2007","unstructured":"Prater DN, Case J, Ingram DA, Yoder MC (2007) Working hypothesis to redefine endothelial progenitor cells. Leukemia 21:1141\u20131149","journal-title":"Leukemia"},{"key":"505_CR30","doi-asserted-by":"crossref","unstructured":"Estes ML, Mund JA, Ingram DA, Case J (2010) Identification of endothelial cells and progenitor cell subsets in human peripheral blood. Curr Protoc Cytom Chapter 9:Unit 9.33.31-11.","DOI":"10.1002\/0471142956.cy0933s52"},{"key":"505_CR31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.yjmcc.2010.07.009","volume":"50","author":"MR Richardson","year":"2011","unstructured":"Richardson MR, Yoder MC (2011) Endothelial progenitor cells: quo vadis? J Mol Cell Cardiol 50:266\u2013272","journal-title":"J Mol Cell Cardiol"},{"key":"505_CR32","doi-asserted-by":"crossref","first-page":"R205","DOI":"10.1186\/ar3180","volume":"12","author":"Y Yamaguchi","year":"2010","unstructured":"Yamaguchi Y, Okazaki Y, Seta N, Satoh T, Takahashi K, Ikezawa Z et al (2010) Enhanced angiogenic potency of monocytic endothelial progenitor cells in patients with systemic sclerosis. Arthritis Res Ther 12:R205","journal-title":"Arthritis Res Ther"},{"key":"505_CR33","first-page":"175","volume":"28","author":"Y Yamaguchi","year":"2013","unstructured":"Yamaguchi Y, Kuwana M (2013) Proangiogenic hematopoietic cells of monocytic origin: roles in vascular regeneration and pathogenic processes of systemic sclerosis. Histol Histopathol 28:175\u2013183","journal-title":"Histol Histopathol"},{"key":"505_CR34","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s00018-011-0778-3","volume":"68","author":"LF Lau","year":"2011","unstructured":"Lau LF (2011) CCN1\/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68:3149\u20133163","journal-title":"Cell Mol Life Sci"},{"key":"505_CR35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood-2006-07-036202","volume":"110","author":"K Grote","year":"2007","unstructured":"Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B (2007) The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration. Blood 110:877\u2013885","journal-title":"Blood"},{"key":"505_CR36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/exd.12602","volume":"24","author":"R Saigusa","year":"2015","unstructured":"Saigusa R, Asano Y, Taniguchi T, Yamashita T, Takahashi T, Ichimura Y et al (2015) A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis. Exp Dermatol 24:127\u2013132","journal-title":"Exp Dermatol"},{"key":"505_CR37","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar596","volume":"4","author":"O Distler","year":"2002","unstructured":"Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S et al (2002) Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 4:R11","journal-title":"Arthritis Res"},{"key":"505_CR38","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/rheumatology\/keq392","volume":"50","author":"M Michalska-Jakubus","year":"2011","unstructured":"Michalska-Jakubus M, Kowal-Bielecka O, Chodorowska G, Bielecki M, Krasowska D (2011) Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease. Rheumatology (Oxford) 50:746\u2013755","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR39","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/6b021f46-17bd-4ffe-a378-a1b8d24a1398","volume":"3","author":"JN Fleming","year":"2008","unstructured":"Fleming JN, Nash RA, McLeod DO, Fiorentino DF, Shulman HM, Connolly MK et al (2008) Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One 3, e1452","journal-title":"PLoS One"},{"key":"505_CR40","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.2353\/ajpath.2010.090593","volume":"176","author":"Y Asano","year":"2010","unstructured":"Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G et al (2010) Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 176:1983\u20131998","journal-title":"Am J Pathol"},{"key":"505_CR41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/rheumatology\/kes379","volume":"52","author":"S Noda","year":"2013","unstructured":"Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T et al (2013) Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. Rheumatology (Oxford) 52:790\u2013799","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR42","volume":"7","author":"S Noda","year":"2012","unstructured":"Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T et al (2012) A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS One 7, e32272","journal-title":"PLoS One"},{"key":"505_CR43","author":"T Takahashi","year":"2015","unstructured":"Takahashi T, Asano Y, Noda S, Aozasa N, Akamata K, Taniguchi T et al (2015) A possible contribution of lipocalin-2 to the development of dermal fibrosis, pulmonary vascular involvement, and renal dysfunction in systemic sclerosis. Br J Dermatol. doi: 10.1111\/bjd.13779","journal-title":"Br J Dermatol"},{"key":"505_CR44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fgene.2015.00037","volume":"6","author":"J Thalgott","year":"2015","unstructured":"Thalgott J, Dos-Santos-Luis D, Lebrin F (2015) Pericytes as targets in hereditary hemorrhagic telangiectasia. Front Genet 6:37","journal-title":"Front Genet"},{"key":"505_CR45","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/rheumatology\/kei244","volume":"45","author":"FK Tan","year":"2006","unstructured":"Tan FK, Zhou X, Mayes MD, Gourh P, Guo X, Marcum C et al (2006) Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford) 45:694\u2013702","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR46","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4049\/jimmunol.0901778","volume":"185","author":"A Yoshizaki","year":"2010","unstructured":"Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y et al (2010) Cell adhesion molecules regulate fibrotic process via Th1\/Th2\/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol 185:2502\u20132515","journal-title":"J Immunol"},{"key":"505_CR47","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/ar3066","volume":"12","author":"N Higashi-Kuwata","year":"2010","unstructured":"Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC et al (2010) Characterization of monocyte\/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arthritis Res Ther 12:R128","journal-title":"Arthritis Res Ther"},{"key":"505_CR48","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3109\/s10165-012-0813-8","volume":"23","author":"S Yukawa","year":"2013","unstructured":"Yukawa S, Yamaoka K, Sawamukai N, Shimajiri S, Kubo S, Miyagawa I et al (2013) Dermal mast cell density in fingers reflects severity of skin sclerosis in systemic sclerosis. Mod Rheumatol 23:1151\u20131157","journal-title":"Mod Rheumatol"},{"key":"505_CR49","first-page":"275","volume":"33","author":"T Matsushita","year":"2006","unstructured":"Matsushita T, Hasegawa M, Hamaguchi Y, Takehara K, Sato S (2006) Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis. J Rheumatol 33:275\u2013284","journal-title":"J Rheumatol"},{"key":"505_CR50","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/ar4430","volume":"16","author":"X Yang","year":"2014","unstructured":"Yang X, Yang J, Xing X, Wan L, Li M (2014) Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction. Arthritis Res Ther 16:R4","journal-title":"Arthritis Res Ther"},{"key":"505_CR51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0923-1811(01)00128-1","volume":"27","author":"S Sato","year":"2001","unstructured":"Sato S, Hasegawa M, Takehara K (2001) Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci 27:140\u2013146","journal-title":"J Dermatol Sci"},{"key":"505_CR52","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.1100591","volume":"188","author":"T Nakashima","year":"2012","unstructured":"Nakashima T, Jinnin M, Yamane K, Honda N, Kajihara I, Makino T et al (2012) Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. J Immunol 188:3573\u20133583","journal-title":"J Immunol"},{"key":"505_CR53","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/1529-0131(199811)41:11<2039::AID-ART20>3.0.CO;2-1","volume":"41","author":"C Chizzolini","year":"1998","unstructured":"Chizzolini C, Rezzonico R, Ribbens C, Burger D, Wollheim FA, Dayer JM (1998) Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts. Arthritis Rheum 41:2039\u20132047","journal-title":"Arthritis Rheum"},{"key":"505_CR54","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/art.11129","volume":"48","author":"C Chizzolini","year":"2003","unstructured":"Chizzolini C, Parel Y, De Luca C, Tyndall A, Akesson A, Scheja A et al (2003) Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha. Arthritis Rheum 48:2593\u20132604","journal-title":"Arthritis Rheum"},{"key":"505_CR55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00870304","volume":"21","author":"C Chizzolini","year":"1999","unstructured":"Chizzolini C (1999) T lymphocyte and fibroblast interactions: the case of skin involvement in systemic sclerosis and other examples. Springer Semin Immunopathol 21:431\u2013450","journal-title":"Springer Semin Immunopathol"},{"key":"505_CR56","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/rheumatology\/36.12.1270","volume":"36","author":"H Ihn","year":"1997","unstructured":"Ihn H, Sato S, Fujimoto M, Kikuchi K, Kadono T, Tamaki K et al (1997) Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines. Br J Rheumatol 36:1270\u20131275","journal-title":"Br J Rheumatol"},{"key":"505_CR57","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/clin.1993.1100","volume":"68","author":"PP Sfikakis","year":"1993","unstructured":"Sfikakis PP, Tesar J, Baraf H, Lipnick R, Klipple G, Tsokos GC (1993) Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. Clin Immunol Immunopathol 68:88\u201392","journal-title":"Clin Immunol Immunopathol"},{"key":"505_CR58","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/rheumatology\/37.11.1188","volume":"37","author":"H Ihn","year":"1998","unstructured":"Ihn H, Sato S, Fujimoto M, Takehara K, Tamaki K (1998) Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis. Br J Rheumatol 37:1188\u20131192","journal-title":"Br J Rheumatol"},{"key":"505_CR59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s002960000072","volume":"20","author":"AA Shahin","year":"2000","unstructured":"Shahin AA, Anwar S, Elawar AH, Sharaf AE, Hamid MA, Eleinin AA et al (2000) Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function. Rheumatol Int 20:21\u201324","journal-title":"Rheumatol Int"},{"key":"505_CR60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10067-004-0987-3","volume":"24","author":"A Kuryliszyn-Moskal","year":"2005","unstructured":"Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S (2005) Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 24:111\u2013116","journal-title":"Clin Rheumatol"},{"key":"505_CR61","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2353\/ajpath.2009.090698","volume":"175","author":"A Kizu","year":"2009","unstructured":"Kizu A, Medici D, Kalluri R (2009) Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy. Am J Pathol 175:1371\u20131373","journal-title":"Am J Pathol"},{"key":"505_CR62","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","volume":"13","author":"EM Zeisberg","year":"2007","unstructured":"Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E et al (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13:952\u2013961","journal-title":"Nat Med"},{"key":"505_CR63","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2353\/ajpath.2009.090096","volume":"175","author":"J Li","year":"2009","unstructured":"Li J, Qu X, Bertram JF (2009) Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 175:1380\u20131388","journal-title":"Am J Pathol"},{"key":"505_CR64","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1165\/rcmb.2009-0031OC","volume":"43","author":"N Hashimoto","year":"2010","unstructured":"Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Kawabe T et al (2010) Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 43:161\u2013172","journal-title":"Am J Respir Cell Mol Biol"},{"key":"505_CR65","doi-asserted-by":"crossref","first-page":"835948","DOI":"10.1155\/2013\/835948","volume":"2013","author":"SA Jimenez","year":"2013","unstructured":"Jimenez SA (2013) Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol 2013:835948","journal-title":"ISRN Rheumatol"},{"key":"505_CR66","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/art.30317","volume":"63","author":"Z Li","year":"2011","unstructured":"Li Z, Jimenez SA (2011) Protein kinase C\u03b4 and c-Abl kinase are required for transforming growth factor \u03b2 induction of endothelial-mesenchymal transition in vitro. Arthritis Rheum 63:2473\u20132483","journal-title":"Arthritis Rheum"},{"key":"505_CR67","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00392-009-0752-3","volume":"98","author":"H Freyhaus ten","year":"2009","unstructured":"ten Freyhaus H, Dumitrescu D, Bovenschulte H, Erdmann E, Rosenkranz S (2009) Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension. Clin Res Cardiol 98:265\u2013267","journal-title":"Clin Res Cardiol"},{"key":"505_CR68","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/rheumatology\/ken104","volume":"47","author":"PP Sfikakis","year":"2008","unstructured":"Sfikakis PP, Gorgoulis VG, Katsiari CG, Evangelou K, Kostopoulos C, Black CM (2008) Imatinib for the treatment of refractory, diffuse systemic sclerosis. Rheumatology (Oxford) 47:735\u2013737","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/13543784.2012.632408","volume":"21","author":"H Freyhaus ten","year":"2012","unstructured":"ten Freyhaus H, Dumitrescu D, Berghausen E, Vantler M, Caglayan E, Rosenkranz S (2012) Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs 21:119\u2013134","journal-title":"Expert Opin Investig Drugs"},{"key":"505_CR70","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-F","volume":"340","author":"DS Celermajer","year":"1992","unstructured":"Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID et al (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111\u20131115","journal-title":"Lancet"},{"key":"505_CR71","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.CIR.91.5.1314","volume":"91","author":"R Joannides","year":"1995","unstructured":"Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C et al (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314\u20131319","journal-title":"Circulation"},{"key":"505_CR72","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/01.HYP.0000049624.99844.3D","volume":"41","author":"X Peng","year":"2003","unstructured":"Peng X, Haldar S, Deshpande S, Irani K, Kass DA (2003) Wall stiffness suppresses Akt\/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension 41:378\u2013381","journal-title":"Hypertension"},{"key":"505_CR73","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.RES.0000181432.73920.b1","volume":"97","author":"M Li","year":"2005","unstructured":"Li M, Chiou KR, Bugayenko A, Irani K, Kass DA (2005) Reduced wall compliance suppresses Akt-dependent apoptosis protection stimulated by pulse perfusion. Circ Res 97:587\u2013595","journal-title":"Circ Res"},{"issue":"1555\u20131557","key":"505_CR74","first-page":"A8","volume":"82","author":"J Lekakis","year":"1998","unstructured":"Lekakis J, Papamichael C, Mavrikakis M, Voutsas A, Stamatelopoulos S (1998) Effect of long-term estrogen therapy on brachial arterial endothelium-dependent vasodilation in women with Raynaud\u2019s phenomenon secondary to systemic sclerosis. Am J Cardiol 82(1555\u20131557):A8","journal-title":"Am J Cardiol"},{"key":"505_CR75","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0002-8703(98)70137-1","volume":"136","author":"J Lekakis","year":"1998","unstructured":"Lekakis J, Mavrikakis M, Papamichael C, Papazoglou S, Economou O, Scotiniotis I et al (1998) Short-term estrogen administration improves abnormal endothelial function in women with systemic sclerosis and Raynaud\u2019s phenomenon. Am Heart J 136:905\u2013912","journal-title":"Am Heart J"},{"key":"505_CR76","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/rheumatology\/kel426","volume":"46","author":"G Szucs","year":"2007","unstructured":"Szucs G, T\u00edm\u00e1r O, Szekanecz Z, D\u00e9r H, Kerekes G, Szamosi S et al (2007) Endothelial dysfunction precedes atherosclerosis in systemic sclerosis\u2014relevance for prevention of vascular complications. Rheumatology (Oxford) 46:759\u2013762","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR77","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1196\/annals.1422.030","volume":"1108","author":"F Bartoli","year":"2007","unstructured":"Bartoli F, Blagojevic J, Bacci M, Fiori G, Tempestini A, Conforti ML et al (2007) Flow-mediated vasodilation and carotid intima-media thickness in systemic sclerosis. Ann N Y Acad Sci 1108:283\u2013290","journal-title":"Ann N Y Acad Sci"},{"key":"505_CR78","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3899\/jrheum.091116","volume":"37","author":"D Rollando","year":"2010","unstructured":"Rollando D, Bezante GP, Sulli A, Balbi M, Panico N, Pizzorni C et al (2010) Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment. J Rheumatol 37:1168\u20131173","journal-title":"J Rheumatol"},{"key":"505_CR79","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1475-097X.2010.00965.x","volume":"30","author":"P Rossi","year":"2010","unstructured":"Rossi P, Granel B, Marziale D, Le M\u00e9e F, Franc\u00e8s Y (2010) Endothelial function and hemodynamics in systemic sclerosis. Clin Physiol Funct Imaging 30:453\u2013459","journal-title":"Clin Physiol Funct Imaging"},{"key":"505_CR80","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s10067-008-0958-1","volume":"27","author":"A Cypiene","year":"2008","unstructured":"Cypiene A, Laucevicius A, Venalis A, Dadoniene J, Ryliskyte L, Petrulioniene Z et al (2008) The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function. Clin Rheumatol 27:1517\u20131522","journal-title":"Clin Rheumatol"},{"key":"505_CR81","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/HJH.0b013e328032784f","volume":"25","author":"C Giannattasio","year":"2007","unstructured":"Giannattasio C, Pozzi M, Gardinali M, Gradinali M, Montemerlo E, Citterio F et al (2007) Effects of prostaglandin E1alpha cyclodextrin [corrected] treatment on endothelial dysfunction in patients with systemic sclerosis. J Hypertens 25:793\u2013797","journal-title":"J Hypertens"},{"key":"505_CR82","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<273::AID-PATH413>3.0.CO;2-4","volume":"189","author":"SA Cotton","year":"1999","unstructured":"Cotton SA, Herrick AL, Jayson MI, Freemont AJ (1999) Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin. J Pathol 189:273\u2013278","journal-title":"J Pathol"},{"key":"505_CR83","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/rheumatology\/kei276","volume":"45","author":"A Dooley","year":"2006","unstructured":"Dooley A, Gao B, Bradley N, Abraham DJ, Black CM, Jacobs M et al (2006) Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine. Rheumatology (Oxford) 45:676\u2013684","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR84","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.10191","volume":"46","author":"GN Andersen","year":"2002","unstructured":"Andersen GN, Mincheva-Nilsson L, Kazzam E, Nyberg G, Klintland N, Petersson AS et al (2002) Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production. Arthritis Rheum 46:1324\u20131332","journal-title":"Arthritis Rheum"},{"issue":"10","key":"505_CR85","first-page":"1566","volume":"19","author":"K Yamane","year":"1992","unstructured":"Yamane K, Miyauchi T, Suzuki N, Yuhara T, Akama T, Suzuki H et al (1992) Significance of plasma endothelin-1 levels in patients with systemic sclerosis. J Rheumatol 19(10):1566\u20131571","journal-title":"J Rheumatol"},{"key":"505_CR86","first-page":"1838","volume":"21","author":"R Vancheeswaran","year":"1994","unstructured":"Vancheeswaran R, Magoulas T, Efrat G, Wheeler-Jones C, Olsen I, Penny R et al (1994) Circulating endothelin-1 levels in systemic sclerosis subsets\u2014a marker of fibrosis or vascular dysfunction? J Rheumatol 21:1838\u20131844","journal-title":"J Rheumatol"},{"key":"505_CR87","author":"U Marvi","year":"2010","unstructured":"Marvi U, Chung L (2010) Digital ischemic loss in systemic sclerosis. Int J Rheumatol. doi: 10.1155\/2010\/130717","journal-title":"Int J Rheumatol"},{"key":"505_CR88","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00002281-199411000-00013","volume":"6","author":"MB Kahaleh","year":"1994","unstructured":"Kahaleh MB (1994) Raynaud\u2019s phenomenon and vascular disease in scleroderma. Curr Opin Rheumatol 6:621\u2013627","journal-title":"Curr Opin Rheumatol"},{"key":"505_CR89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.autrev.2005.08.004","volume":"5","author":"L Chung","year":"2006","unstructured":"Chung L, Fiorentino D (2006) Digital ulcers in patients with systemic sclerosis. Autoimmun Rev 5:125\u2013128","journal-title":"Autoimmun Rev"},{"key":"505_CR90","author":"E Schiopu","year":"2010","unstructured":"Schiopu E, Impens AJ, Phillips K (2010) Digital ischemia in scleroderma spectrum of diseases. Int J Rheumatol. doi: 10.1155\/2010\/923743","journal-title":"Int J Rheumatol"},{"key":"505_CR91","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/ncomms6797","volume":"5","author":"S Noda","year":"2014","unstructured":"Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I et al (2014) Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis. Nat Commun 5:5797","journal-title":"Nat Commun"},{"key":"505_CR92","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/cvr\/cvp220","volume":"84","author":"R Kundi","year":"2009","unstructured":"Kundi R, Hollenbeck ST, Yamanouchi D, Herman BC, Edlin R, Ryer EJ et al (2009) Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. Cardiovasc Res 84:326\u2013335","journal-title":"Cardiovasc Res"},{"key":"505_CR93","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1056\/NEJMoa055120","volume":"354","author":"DP Tashkin","year":"2006","unstructured":"Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE et al (2006) Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 354:2655\u20132666","journal-title":"N Engl J Med"},{"key":"505_CR94","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1002\/art.22204","volume":"54","author":"RK Hoyles","year":"2006","unstructured":"Hoyles RK, Ellis RW, Wellsbury J, Lees B, Newlands P, Goh NS et al (2006) A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum 54:3962\u20133970","journal-title":"Arthritis Rheum"},{"issue":"Suppl 1","key":"505_CR95","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.rmed.2010.03.018","volume":"104","author":"L Mouthon","year":"2010","unstructured":"Mouthon L, Berezne A, Guillevin L, Valeyre D (2010) Therapeutic options for systemic sclerosis related interstitial lung diseases. Respir Med 104(Suppl 1):S59\u2013S69","journal-title":"Respir Med"},{"key":"505_CR96","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncprheum0346","volume":"2","author":"LI Sakkas","year":"2006","unstructured":"Sakkas LI, Chikanza IC, Platsoucas CD (2006) Mechanisms of disease: the role of immune cells in the pathogenesis of systemic sclerosis. Nat Clin Pract Rheumatol 2:679\u2013685","journal-title":"Nat Clin Pract Rheumatol"},{"key":"505_CR97","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/art.20542","volume":"51","author":"R Casale","year":"2004","unstructured":"Casale R, Generini S, Luppi F, Pignone A, Matucci-Cerinic M (2004) Pulse cyclophosphamide decreases sympathetic postganglionic activity, controls alveolitis, and normalizes vascular tone dysfunction (Raynaud\u2019s phenomenon) in a case of early systemic sclerosis. Arthritis Rheum 51:665\u2013669","journal-title":"Arthritis Rheum"},{"key":"505_CR98","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/art.11081","volume":"48","author":"S Apras","year":"2003","unstructured":"Apras S, Ertenli I, Ozbalkan Z, Kiraz S, Ozturk MA, Haznedaroglu IC et al (2003) Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis. Arthritis Rheum 48:2256\u20132261","journal-title":"Arthritis Rheum"},{"key":"505_CR99","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10067-008-1058-y","volume":"28","author":"P Caramaschi","year":"2009","unstructured":"Caramaschi P, Volpe A, Pieropan S, Tinazzi I, Mahamid H, Bambara LM et al (2009) Cyclophosphamide treatment improves microvessel damage in systemic sclerosis. Clin Rheumatol 28:391\u2013395","journal-title":"Clin Rheumatol"},{"key":"505_CR100","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/rheumatology\/keq259","volume":"49","author":"Y Furuya","year":"2010","unstructured":"Furuya Y, Okazaki Y, Kaji K, Sato S, Takehara K, Kuwana M (2010) Mobilization of endothelial progenitor cells by intravenous cyclophosphamide in patients with systemic sclerosis. Rheumatology (Oxford) 49:2375\u20132380","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR101","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/qjmed\/hct111","volume":"106","author":"H Penn","year":"2013","unstructured":"Penn H, Quillinan N, Khan K, Chakravarty K, Ong VH, Burns A et al (2013) Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility. QJM 106:839\u2013848","journal-title":"QJM"},{"key":"505_CR102","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/rheumatology\/ker414","volume":"51","author":"M Frerix","year":"2012","unstructured":"Frerix M, Stegbauer J, Dragun D, Kreuter A, Weiner SM (2012) Ulnar artery occlusion is predictive of digital ulcers in SSc: a duplex sonography study. Rheumatology (Oxford) 51:735\u2013742","journal-title":"Rheumatology (Oxford)"},{"key":"505_CR103","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/ard.2010.130658","volume":"70","author":"M Matucci-Cerinic","year":"2011","unstructured":"Matucci-Cerinic M, Denton CP, Furst DE, Mayes MD, Hsu VM, Carpentier P et al (2011) Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 70:32\u201338","journal-title":"Ann Rheum Dis"},{"key":"505_CR104","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1002\/art.20676","volume":"50","author":"JH Korn","year":"2004","unstructured":"Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E et al (2004) Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 50:3985\u20133993","journal-title":"Arthritis Rheum"},{"key":"505_CR105","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3109\/s10165-011-0436-5","volume":"21","author":"Y Ichimura","year":"2011","unstructured":"Ichimura Y, Asano Y, Hatano M, Tamaki Z, Takekoshi T, Kogure A et al (2011) Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene. Mod Rheumatol 21:548\u2013552","journal-title":"Mod Rheumatol"},{"key":"505_CR106","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.lfs.2014.01.008","volume":"118","author":"M Abdelsaid","year":"2014","unstructured":"Abdelsaid M, Kaczmarek J, Coucha M, Ergul A (2014) Dual endothelin receptor antagonism with bosentan reverses established vascular remodeling and dysfunctional angiogenesis in diabetic rats: relevance to glycemic control. Life Sci 118:268\u2013273","journal-title":"Life Sci"},{"key":"505_CR107","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10585-006-9016-z","volume":"23","author":"D Dr\u00e9au","year":"2006","unstructured":"Dr\u00e9au D, Karaa A, Culberson C, Wyan H, McKillop IH, Clemens MG (2006) Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. Clin Exp Metastasis 23:41\u201353","journal-title":"Clin Exp Metastasis"},{"key":"505_CR108","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s10067-012-2074-5","volume":"31","author":"S Guiducci","year":"2012","unstructured":"Guiducci S, Bellando Randone S, Bruni C, Carnesecchi G, Maresta A, Iannone F et al (2012) Bosentan fosters microvascular de-remodelling in systemic sclerosis. Clin Rheumatol 31:1723\u20131725","journal-title":"Clin Rheumatol"},{"key":"505_CR109","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3899\/jrheum.120416","volume":"40","author":"M Cutolo","year":"2013","unstructured":"Cutolo M, Zampogna G, Vremis L, Smith V, Pizzorni C, Sulli A (2013) Longterm effects of endothelin receptor antagonism on microvascular damage evaluated by nailfold capillaroscopic analysis in systemic sclerosis. J Rheumatol 40:40\u201345","journal-title":"J Rheumatol"},{"key":"505_CR110","author":"K Akamata","year":"2015","unstructured":"Akamata K, Asano Y, Yamashita T, Noda S, Taniguchi T, Takahashi T et al (2015) Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli1 knockout mice by increasing Fli1 DNA-binding ability. Arthr Rheumatol. doi: 10.1002\/art.39062","journal-title":"Arthr Rheumatol"},{"key":"505_CR111","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1128\/MCB.01320-08","volume":"29","author":"Y Asano","year":"2009","unstructured":"Asano Y, Trojanowska M (2009) Phosphorylation of Fli1 at threonine 312 by protein kinase C \u03b4 promotes its interaction with p300\/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor \u03b2. Mol Cell Biol 29:1882\u20131894","journal-title":"Mol Cell Biol"},{"key":"505_CR112","doi-asserted-by":"crossref","first-page":"34672","DOI":"10.1074\/jbc.M703907200","volume":"282","author":"Y Asano","year":"2007","unstructured":"Asano Y, Czuwara J, Trojanowska M (2007) Transforming growth factor-\u03b2 regulates DNA binding activity of transcription factor Fli1 by p300\/CREB-binding protein-associated factor-dependent acetylation. J Biol Chem 282:34672\u201334683","journal-title":"J Biol Chem"},{"key":"505_CR113","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0002-9440(10)63685-1","volume":"163","author":"M Kubo","year":"2003","unstructured":"Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM et al (2003) Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163:571\u2013581","journal-title":"Am J Pathol"},{"key":"505_CR114","author":"S Jordan","year":"2014","unstructured":"Jordan S, Distler JH, Maurer B, Huscher D, van Laar JM, Allanore Y et al (2014) Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group. Ann Rheum Dis. doi: 10.1136\/annrheumdis-2013-204522","journal-title":"Ann Rheum Dis"},{"key":"505_CR115","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/1346-8138.12461","volume":"41","author":"H Sumida","year":"2014","unstructured":"Sumida H, Asano Y, Tamaki Z, Aozasa N, Taniguchi T, Takahashi T et al (2014) Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus. J Dermatol 41:418\u2013420","journal-title":"J Dermatol"},{"key":"505_CR116","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10067-014-2579-1","volume":"33","author":"CG Khor","year":"2014","unstructured":"Khor CG, Chen XL, Lin TS, Lu CH, Hsieh SC (2014) Rituximab for refractory digital infarcts and ulcers in systemic sclerosis. Clin Rheumatol 33:1019\u20131020","journal-title":"Clin Rheumatol"},{"key":"505_CR117","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.semarthrit.2011.11.007","volume":"41","author":"D Daoussis","year":"2012","unstructured":"Daoussis D, Antonopoulos I, Liossis SN, Yiannopoulos G, Andonopoulos AP (2012) Treatment of systemic sclerosis-associated calcinosis: a case report of rituximab-induced regression of CREST-related calcinosis and review of the literature. Semin Arthritis Rheum 41:822\u2013829","journal-title":"Semin Arthritis Rheum"},{"issue":"6 Suppl 86","key":"505_CR118","first-page":"S-228","volume":"32","author":"AL Maslyanskiy","year":"2014","unstructured":"Maslyanskiy AL, Lapin SV, Kolesova EP, Penin IN, Cheshuina MD, Feist E et al (2014) Effects of rituximab therapy on elastic properties of vascular wall in patients with progressive systemic sclerosis. Clin Exp Rheumatol 32(6 Suppl 86):S-228","journal-title":"Clin Exp Rheumatol"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-015-0505-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00281-015-0505-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-015-0505-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:12:15Z","timestamp":1559038335000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00281-015-0505-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,8]]},"references-count":118,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["505"],"URL":"https:\/\/doi.org\/10.1007\/s00281-015-0505-5","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,8]]}}}