{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:07:34Z","timestamp":1793394454788,"version":"4.5.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00281-016-0558-0","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T05:21:40Z","timestamp":1457587300000},"page":"471-482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":415,"title":["The host immune response in respiratory virus infection: balancing virus clearance and immunopathology"],"prefix":"10.1007","volume":"38","author":[{"given":"Amy H.","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Cardani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Braciale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"issue":"27","key":"558_CR1","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.vaccine.2007.03.046","volume":"25","author":"NA Molinari","year":"2007","unstructured":"Molinari NA et al (2007) The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine 25(27):5086\u201396","journal-title":"Vaccine"},{"issue":"1","key":"558_CR2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1189\/jlb.1011530","volume":"92","author":"S Herold","year":"2012","unstructured":"Herold S et al (2012) Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury. J Leukoc Biol 92(1):75\u201382","journal-title":"J Leukoc Biol"},{"issue":"1","key":"558_CR3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12101","volume":"255","author":"RK Durbin","year":"2013","unstructured":"Durbin RK, Kotenko SV, Durbin JE (2013) Interferon induction and function at the mucosal surface. Immunol Rev 255(1):25\u201339","journal-title":"Immunol Rev"},{"issue":"4","key":"558_CR4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","volume":"14","author":"CE Samuel","year":"2001","unstructured":"Samuel CE (2001) Antiviral actions of interferons. Clin Microbiol Rev 14(4):778\u2013809, table of contents","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"558_CR5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri3806","volume":"15","author":"J Crouse","year":"2015","unstructured":"Crouse J, Kalinke U, Oxenius A (2015) Regulation of antiviral T cell responses by type I interferons. Nat Rev Immunol 15(4):231\u201342","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"558_CR6","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.4049\/jimmunol.176.7.4343","volume":"176","author":"ES Coro","year":"2006","unstructured":"Coro ES, Chang WL, Baumgarth N (2006) Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. J Immunol 176(7):4343\u201351","journal-title":"J Immunol"},{"issue":"14","key":"558_CR7","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1128\/JVI.02438-06","volume":"81","author":"Z Zhou","year":"2007","unstructured":"Zhou Z et al (2007) Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J Virol 81(14):7749\u201358","journal-title":"J Virol"},{"issue":"1\u20132","key":"558_CR8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.virusres.2011.07.011","volume":"160","author":"T Okabayashi","year":"2011","unstructured":"Okabayashi T et al (2011) Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. Virus Res 160(1\u20132):360\u20136","journal-title":"Virus Res"},{"issue":"21","key":"558_CR9","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1128\/JVI.01703-09","volume":"84","author":"NA Jewell","year":"2010","unstructured":"Jewell NA et al (2010) Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo. J Virol 84(21):11515\u201322","journal-title":"J Virol"},{"issue":"6","key":"558_CR10","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.4049\/jimmunol.175.6.3463","volume":"175","author":"SA Jones","year":"2005","unstructured":"Jones SA (2005) Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 175(6):3463\u20138","journal-title":"J Immunol"},{"key":"558_CR11","first-page":"3","volume":"386","author":"JR Teijaro","year":"2015","unstructured":"Teijaro JR (2015) The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options. Curr Top Microbiol Immunol 386:3\u201322","journal-title":"Curr Top Microbiol Immunol"},{"issue":"7","key":"558_CR12","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/rheumatology\/keq031","volume":"49","author":"T Horiuchi","year":"2010","unstructured":"Horiuchi T et al (2010) Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford) 49(7):1215\u201328","journal-title":"Rheumatology (Oxford)"},{"issue":"4746","key":"558_CR13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1126\/science.2420009","volume":"232","author":"LM Souza","year":"1986","unstructured":"Souza LM et al (1986) Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 232(4746):61\u20135","journal-title":"Science"},{"issue":"10","key":"558_CR14","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI62139","volume":"122","author":"B Unkel","year":"2012","unstructured":"Unkel B et al (2012) Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest 122(10):3652\u201364","journal-title":"J Clin Invest"},{"issue":"2","key":"558_CR15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201012-2036OC","volume":"184","author":"FF Huang","year":"2011","unstructured":"Huang FF et al (2011) GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med 184(2):259\u201368","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"558_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1074-7613(01)00218-7","volume":"15","author":"Y Shibata","year":"2001","unstructured":"Shibata Y et al (2001) GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 15(4):557\u201367","journal-title":"Immunity"},{"issue":"4","key":"558_CR17","first-page":"391","volume":"72","author":"N Mukaida","year":"2000","unstructured":"Mukaida N (2000) Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int J Hematol 72(4):391\u20138","journal-title":"Int J Hematol"},{"issue":"8","key":"558_CR18","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/eji.200838155","volume":"38","author":"DM Lindell","year":"2008","unstructured":"Lindell DM, Lane TE, Lukacs NW (2008) CXCL10\/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol 38(8):2168\u201379","journal-title":"Eur J Immunol"},{"issue":"1","key":"558_CR19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201203-0508OC","volume":"187","author":"A Ichikawa","year":"2013","unstructured":"Ichikawa A et al (2013) CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med 187(1):65\u201377","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"558_CR20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/cr.2013.25","volume":"23","author":"W Wang","year":"2013","unstructured":"Wang W et al (2013) Monoclonal antibody against CXCL-10\/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Res 23(4):577\u201380","journal-title":"Cell Res"},{"key":"558_CR21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","volume":"32","author":"JW Griffith","year":"2014","unstructured":"Griffith JW, Sokol CL, Luster AD (2014) Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol 32:659\u2013702","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"558_CR22","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1002\/1521-4141(200211)32:11<3276::AID-IMMU3276>3.0.CO;2-5","volume":"32","author":"KK Tekkanat","year":"2002","unstructured":"Tekkanat KK et al (2002) RANTES (CCL5) production during primary respiratory syncytial virus infection exacerbates airway disease. Eur J Immunol 32(11):3276\u201384","journal-title":"Eur J Immunol"},{"issue":"11","key":"558_CR23","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","volume":"11","author":"JW Tyner","year":"2005","unstructured":"Tyner JW et al (2005) CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med 11(11):1180\u20137","journal-title":"Nat Med"},{"key":"558_CR24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1146\/annurev.physiol.64.081501.134340","volume":"64","author":"BC Schutte","year":"2002","unstructured":"Schutte BC, McCray PB Jr (2002) [beta]-defensins in lung host defense. Annu Rev Physiol 64:709\u201348","journal-title":"Annu Rev Physiol"},{"issue":"22","key":"558_CR25","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1007\/s00018-005-5372-0","volume":"62","author":"P Valenti","year":"2005","unstructured":"Valenti P, Antonini G (2005) Lactoferrin: an important host defence against microbial and viral attack. Cell Mol Life Sci 62(22):2576\u201387","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"558_CR26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","volume":"111","author":"J Zhu","year":"2002","unstructured":"Zhu J et al (2002) Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 111(6):867\u201378","journal-title":"Cell"},{"issue":"2","key":"558_CR27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5021\/ad.2012.24.2.126","volume":"24","author":"M Reinholz","year":"2012","unstructured":"Reinholz M, Ruzicka T, Schauber J (2012) Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. Ann Dermatol 24(2):126\u201335","journal-title":"Ann Dermatol"},{"issue":"1","key":"558_CR28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/CMR.00014-10","volume":"24","author":"M Vareille","year":"2011","unstructured":"Vareille M et al (2011) The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev 24(1):210\u201329","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"558_CR29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2006.01.037","volume":"41","author":"W Xu","year":"2006","unstructured":"Xu W et al (2006) Role of epithelial nitric oxide in airway viral infection. Free Radic Biol Med 41(1):19\u201328","journal-title":"Free Radic Biol Med"},{"key":"558_CR30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.med.60.041807.123500","volume":"61","author":"JA Whitsett","year":"2010","unstructured":"Whitsett JA, Wert SE, Weaver TE (2010) Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Annu Rev Med 61:105\u201319","journal-title":"Annu Rev Med"},{"key":"558_CR31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2741\/s83","volume":"2","author":"KL Hartshorn","year":"2010","unstructured":"Hartshorn KL (2010) Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense. Front Biosci (Schol Ed) 2:527\u201346","journal-title":"Front Biosci (Schol Ed)"},{"issue":"11","key":"558_CR32","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.4049\/jimmunol.174.11.7359","volume":"174","author":"R Arnold","year":"2005","unstructured":"Arnold R, Konig W (2005) Respiratory syncytial virus infection of human lung endothelial cells enhances selectively intercellular adhesion molecule-1 expression. J Immunol 174(11):7359\u201367","journal-title":"J Immunol"},{"key":"558_CR33","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3389\/fmicb.2014.00653","volume":"5","author":"KR Short","year":"2014","unstructured":"Short KR et al (2014) Influenza virus and endothelial cells: a species specific relationship. Front Microbiol 5:653","journal-title":"Front Microbiol"},{"issue":"2","key":"558_CR34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00003246-199602000-00012","volume":"24","author":"GW Hallin","year":"1996","unstructured":"Hallin GW et al (1996) Cardiopulmonary manifestations of hantavirus pulmonary syndrome. Crit Care Med 24(2):252\u20138","journal-title":"Crit Care Med"},{"issue":"1","key":"558_CR35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","volume":"14","author":"KR Short","year":"2014","unstructured":"Short KR et al (2014) Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infect Dis 14(1):57\u201369","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"558_CR36","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.cell.2011.08.015","volume":"146","author":"JR Teijaro","year":"2011","unstructured":"Teijaro JR et al (2011) Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 146(6):980\u201391","journal-title":"Cell"},{"issue":"2","key":"558_CR37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","volume":"14","author":"T Hussell","year":"2014","unstructured":"Hussell T, Bell TJ (2014) Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14(2):81\u201393","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"558_CR38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.20140825","volume":"212","author":"M Goritzka","year":"2015","unstructured":"Goritzka M et al (2015) Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J Exp Med 212(5):699\u2013714","journal-title":"J Exp Med"},{"key":"558_CR39","first-page":"23","volume":"386","author":"B Pulendran","year":"2015","unstructured":"Pulendran B, Maddur MS (2015) Innate immune sensing and response to influenza. Curr Top Microbiol Immunol 386:23\u201371","journal-title":"Curr Top Microbiol Immunol"},{"issue":"7","key":"558_CR40","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.20122220","volume":"210","author":"A Mocsai","year":"2013","unstructured":"Mocsai A (2013) Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J Exp Med 210(7):1283\u201399","journal-title":"J Exp Med"},{"issue":"3","key":"558_CR41","doi-asserted-by":"crossref","first-page":"e1004651","DOI":"10.1371\/journal.ppat.1004651","volume":"11","author":"P Kruger","year":"2015","unstructured":"Kruger P et al (2015) Neutrophils: between host defence, immune modulation, and tissue injury. PLoS Pathog 11(3):e1004651","journal-title":"PLoS Pathog"},{"issue":"6","key":"558_CR42","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/eji.200635977","volume":"36","author":"RJ Snelgrove","year":"2006","unstructured":"Snelgrove RJ et al (2006) An absence of reactive oxygen species improves the resolution of lung influenza infection. Eur J Immunol 36(6):1364\u201373","journal-title":"Eur J Immunol"},{"issue":"5","key":"558_CR43","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.180.5.3319","volume":"180","author":"LP Shornick","year":"2008","unstructured":"Shornick LP et al (2008) Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection. J Immunol 180(5):3319\u201328","journal-title":"J Immunol"},{"issue":"6","key":"558_CR44","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1164\/ajrccm.156.6.96-12081","volume":"156","author":"G Matute-Bello","year":"1997","unstructured":"Matute-Bello G et al (1997) Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 156(6):1969\u201377","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"558_CR45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 13(3):159\u201375","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"558_CR46","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2131","volume":"12","author":"LA Monticelli","year":"2011","unstructured":"Monticelli LA et al (2011) Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol 12(11):1045\u201354","journal-title":"Nat Immunol"},{"issue":"2","key":"558_CR47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2567.2009.03167.x","volume":"128","author":"FJ Culley","year":"2009","unstructured":"Culley FJ (2009) Natural killer cells in infection and inflammation of the lung. Immunology 128(2):151\u201363","journal-title":"Immunology"},{"key":"558_CR48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-032712-100001","volume":"31","author":"S Jost","year":"2013","unstructured":"Jost S, Altfeld M (2013) Control of human viral infections by natural killer cells. Annu Rev Immunol 31:163\u201394","journal-title":"Annu Rev Immunol"},{"key":"558_CR49","doi-asserted-by":"crossref","unstructured":"Abboud G et al (2015) Natural killer cells and innate IFN-gamma participate in host defense against respiratory vaccinia virus infection. J Virol","DOI":"10.1128\/JVI.01894-15"},{"issue":"1","key":"558_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/cimm.1996.0245","volume":"173","author":"FJ Kos","year":"1996","unstructured":"Kos FJ, Engleman EG (1996) Role of natural killer cells in the generation of influenza virus-specific cytotoxic T cells. Cell Immunol 173(1):1\u20136","journal-title":"Cell Immunol"},{"issue":"4","key":"558_CR51","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/JVI.06209-11","volume":"86","author":"F Li","year":"2012","unstructured":"Li F et al (2012) Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection. J Virol 86(4):2251\u20138","journal-title":"J Virol"},{"issue":"1","key":"558_CR52","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mi.2012.49","volume":"6","author":"P Kumar","year":"2013","unstructured":"Kumar P et al (2013) IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol 6(1):69\u201382","journal-title":"Mucosal Immunol"},{"key":"558_CR53","first-page":"379","volume":"6","author":"C Gottschalk","year":"2015","unstructured":"Gottschalk C, Mettke E, Kurts C (2015) The role of invariant natural killer T cells in dendritic cell licensing, cross-priming, and memory CD8(+) T cell generation. Front Immunol 6:379","journal-title":"Front Immunol"},{"issue":"8","key":"558_CR54","doi-asserted-by":"crossref","first-page":"e1002838","DOI":"10.1371\/journal.ppat.1002838","volume":"8","author":"JA Juno","year":"2012","unstructured":"Juno JA, Keynan Y, Fowke KR (2012) Invariant NKT cells: regulation and function during viral infection. PLoS Pathog 8(8):e1002838","journal-title":"PLoS Pathog"},{"issue":"3","key":"558_CR55","first-page":"151","volume":"1","author":"WK Born","year":"2000","unstructured":"Born WK et al (2000) Role of gammadelta T cells in protecting normal airway function. Respir Res 1(3):151\u20138","journal-title":"Respir Res"},{"issue":"9","key":"558_CR56","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1086\/502975","volume":"193","author":"F Poccia","year":"2006","unstructured":"Poccia F et al (2006) Anti-severe acute respiratory syndrome coronavirus immune responses: the role played by V gamma 9V delta 2 T cells. J Infect Dis 193(9):1244\u20139","journal-title":"J Infect Dis"},{"issue":"2","key":"558_CR57","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.4049\/jimmunol.182.2.1174","volume":"182","author":"J Dodd","year":"2009","unstructured":"Dodd J et al (2009) Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease. J Immunol 182(2):1174\u201381","journal-title":"J Immunol"},{"issue":"10","key":"558_CR58","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1084\/jem.20100061","volume":"207","author":"PL Simonian","year":"2010","unstructured":"Simonian PL et al (2010) Gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207(10):2239\u201353","journal-title":"J Exp Med"},{"issue":"1","key":"558_CR59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/imr.12100","volume":"255","author":"K Neyt","year":"2013","unstructured":"Neyt K, Lambrecht BN (2013) The role of lung dendritic cell subsets in immunity to respiratory viruses. Immunol Rev 255(1):57\u201367","journal-title":"Immunol Rev"},{"issue":"3","key":"558_CR60","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/mi.2013.14","volume":"6","author":"M Guilliams","year":"2013","unstructured":"Guilliams M, Lambrecht BN, Hammad H (2013) Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections. Mucosal Immunol 6(3):464\u201373","journal-title":"Mucosal Immunol"},{"issue":"4","key":"558_CR61","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri3166","volume":"12","author":"TJ Braciale","year":"2012","unstructured":"Braciale TJ, Sun J, Kim TS (2012) Regulating the adaptive immune response to respiratory virus infection. Nat Rev Immunol 12(4):295\u2013305","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"558_CR62","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20052359","volume":"203","author":"JJ Smit","year":"2006","unstructured":"Smit JJ, Rudd BD, Lukacs NW (2006) Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus. J Exp Med 203(5):1153\u20139","journal-title":"J Exp Med"},{"issue":"11","key":"558_CR63","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11(11):762\u201374","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"558_CR64","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1128\/JVI.01281-09","volume":"84","author":"J Chen","year":"2010","unstructured":"Chen J et al (2010) Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB\/c mice: CD4+ T cells are important in control of SARS-CoV infection. J Virol 84(3):1289\u2013301","journal-title":"J Virol"},{"issue":"7","key":"558_CR65","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.4049\/jimmunol.1302503","volume":"193","author":"RS Herati","year":"2014","unstructured":"Herati RS et al (2014) Circulating CXCR5+ PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol 193(7):3528\u201337","journal-title":"J Immunol"},{"issue":"10","key":"558_CR66","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/00005537-199610000-00025","volume":"106","author":"CM Alper","year":"1996","unstructured":"Alper CM et al (1996) Prechallenge antibodies: moderators of infection rate, signs, and symptoms in adults experimentally challenged with rhinovirus type 39. Laryngoscope 106(10):1298\u2013305","journal-title":"Laryngoscope"},{"issue":"1\u20133","key":"558_CR67","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12026-014-8534-z","volume":"59","author":"R Channappanavar","year":"2014","unstructured":"Channappanavar R, Zhao J, Perlman S (2014) T cell-mediated immune response to respiratory coronaviruses. Immunol Res 59(1\u20133):118\u201328","journal-title":"Immunol Res"},{"issue":"18","key":"558_CR68","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1128\/JVI.01049-10","volume":"84","author":"J Zhao","year":"2010","unstructured":"Zhao J, Zhao J, Perlman S (2010) T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol 84(18):9318\u201325","journal-title":"J Virol"},{"issue":"2","key":"558_CR69","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1084\/jem.188.2.223","volume":"188","author":"D Moskophidis","year":"1998","unstructured":"Moskophidis D, Kioussis D (1998) Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. J Exp Med 188(2):223\u201332","journal-title":"J Exp Med"},{"issue":"3","key":"558_CR70","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI115362","volume":"88","author":"BS Graham","year":"1991","unstructured":"Graham BS et al (1991) Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest 88(3):1026\u201333","journal-title":"J Clin Invest"},{"issue":"3","key":"558_CR71","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.coviro.2012.03.008","volume":"2","author":"JL Kennedy","year":"2012","unstructured":"Kennedy JL et al (2012) Pathogenesis of rhinovirus infection. Curr Opin Virol 2(3):287\u201393","journal-title":"Curr Opin Virol"},{"key":"558_CR72","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","volume":"3","author":"JK Taubenberger","year":"2008","unstructured":"Taubenberger JK, Morens DM (2008) The pathology of influenza virus infections. Annu Rev Pathol 3:499\u2013522","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"558_CR73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/modpathol.3800247","volume":"18","author":"DM Hwang","year":"2005","unstructured":"Hwang DM et al (2005) Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol 18(1):1\u201310","journal-title":"Mod Pathol"},{"key":"558_CR74","doi-asserted-by":"crossref","unstructured":"(1998) Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics 102(3):531\u20137","DOI":"10.1542\/peds.102.3.531"},{"issue":"3","key":"558_CR75","doi-asserted-by":"crossref","first-page":"e00165","DOI":"10.1128\/mBio.00165-13","volume":"4","author":"L Josset","year":"2013","unstructured":"Josset L et al (2013) Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. MBio 4(3):e00165\u201313","journal-title":"MBio"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-016-0558-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00281-016-0558-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-016-0558-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-016-0558-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T07:28:10Z","timestamp":1567668490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00281-016-0558-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["558"],"URL":"https:\/\/doi.org\/10.1007\/s00281-016-0558-0","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}