{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:04:53Z","timestamp":1790424293159,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["Z01 AR-041184"],"award-info":[{"award-number":["Z01 AR-041184"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00281-021-00838-z","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T10:27:47Z","timestamp":1611311267000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The enigmatic role of HLA-B*27 in spondyloarthritis pathogenesis"],"prefix":"10.1007","volume":"43","author":[{"given":"Fatemeh","family":"Navid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-4575","authenticated-orcid":false,"given":"Robert A.","family":"Colbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"issue":"2","key":"838_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrrheum.2015.133","volume":"12","author":"MA Brown","year":"2016","unstructured":"Brown MA, Kenna T, Wordsworth BP (2016) Genetics of ankylosing spondylitis-insights into pathogenesis. Nat Rev Rheumatol 12(2):81\u201391. https:\/\/doi.org\/10.1038\/nrrheum.2015.133","journal-title":"Nat Rev Rheumatol"},{"issue":"26","key":"838_CR2","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","volume":"373","author":"D Baeten","year":"2015","unstructured":"Baeten D, Sieper J, Braun J, Baraliakos X, Dougados M, Emery P, Deodhar A, Porter B, Martin R, Andersson M, Mpofu S, Richards HB (2015) Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med 373(26):2534\u20132548. https:\/\/doi.org\/10.1056\/NEJMoa1505066","journal-title":"N Engl J Med"},{"key":"838_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/art.1780380407","volume":"38","author":"J Braun","year":"1995","unstructured":"Braun J, Bollow M, Neure L, Seipelt E, Seyrekbasan F, Herbst H, Eggens U, Distler A, Sieper J (1995) Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum 38:499\u2013505","journal-title":"Arthritis Rheum"},{"key":"838_CR4","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.4049\/jimmunol.170.2.1099","volume":"170","author":"E May","year":"2003","unstructured":"May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, Taurog JD (2003) CD8ab T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol 170:1099\u20131105","journal-title":"J Immunol"},{"key":"838_CR5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1600-065X.1999.tb01317.x","volume":"169","author":"JD Taurog","year":"1999","unstructured":"Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, Sayad A, Stagg AJ, Fox GM, L\u00ea O'Brien A, Rehman M, Zhou M, Weiner AL, Splawski JB, Richardson JA, Hammer RE (1999) Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 169:209\u2013223","journal-title":"Immunol Rev"},{"issue":"4","key":"838_CR6","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/art.21740","volume":"54","author":"TM Tran","year":"2006","unstructured":"Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE, Shang J, Taurog JD (2006) Additional human beta(2)-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 54(4):1317\u20131327","journal-title":"Arthritis Rheum"},{"issue":"1","key":"838_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.0105-2896.2009.00865.x","volume":"233","author":"RA Colbert","year":"2010","unstructured":"Colbert RA, DeLay ML, Klenk EI, Layh-Schmitt G (2010) From HLA-B27 to spondyloarthritis: a journey through the ER. Immunol Rev 233(1):181\u2013202. https:\/\/doi.org\/10.1111\/j.0105-2896.2009.00865.x","journal-title":"Immunol Rev"},{"issue":"9","key":"838_CR8","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1002\/art.24763","volume":"60","author":"ML DeLay","year":"2009","unstructured":"DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA (2009) HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 60(9):2633\u20132643. https:\/\/doi.org\/10.1002\/art.24763","journal-title":"Arthritis Rheum"},{"issue":"7","key":"838_CR9","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nm.2817","volume":"18","author":"JP Sherlock","year":"2012","unstructured":"Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, LaFace DM, Cua DJ (2012) IL-23 induces spondyloarthropathy by acting on ROR-gammat+ CD3+CD4-CD8- entheseal resident T cells. Nat Med 18(7):1069\u20131076. https:\/\/doi.org\/10.1038\/nm.2817","journal-title":"Nat Med"},{"issue":"7","key":"838_CR10","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/art.38638","volume":"66","author":"H Benham","year":"2014","unstructured":"Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet AC, Ruutu M, Kikly K, Wang R, Tseng HW, Thomas GP, Brown MA, Strutton G, McGuckin MA, Thomas R (2014) Interleukin-23 mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheum 66(7):1755\u20131767. https:\/\/doi.org\/10.1002\/art.38638","journal-title":"Arthritis Rheum"},{"issue":"10","key":"838_CR11","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1002\/art.38773","volume":"66","author":"LM Rehaume","year":"2014","unstructured":"Rehaume LM, Mondot S, Aguirre de Carcer D, Velasco J, Benham H, Hasnain SZ et al (2014) ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheum 66(10):2780\u20132792. https:\/\/doi.org\/10.1002\/art.38773","journal-title":"Arthritis Rheum"},{"issue":"9","key":"838_CR12","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1002\/art.40150","volume":"69","author":"RJ Cuthbert","year":"2017","unstructured":"Cuthbert RJ, Fragkakis EM, Dunsmuir R, Li Z, Coles M, Marzo-Ortega H, Giannoudis PV, Jones E, el-Sherbiny YM, McGonagle D (2017) Brief report: group 3 innate lymphoid cells in human enthesis. Arthritis & rheumatology 69(9):1816\u20131822. https:\/\/doi.org\/10.1002\/art.40150","journal-title":"Arthritis & rheumatology"},{"key":"838_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0167-5699(90)90051-A","volume":"11","author":"RJ Benjamin","year":"1990","unstructured":"Benjamin RJ, Parham P (1990) Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 11:137\u2013142","journal-title":"Immunol Today"},{"issue":"6","key":"838_CR14","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.berh.2018.07.012","volume":"31","author":"RA Colbert","year":"2017","unstructured":"Colbert RA, Navid F, Gill T (2017) The role of HLA-B*27 in spondyloarthritis. Best Pract Res Clin Rheumatol 31(6):797\u2013815. https:\/\/doi.org\/10.1016\/j.berh.2018.07.012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"838_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev-immunol-032414-112110","volume":"33","author":"P Bowness","year":"2015","unstructured":"Bowness P (2015) HLA-B27. Annu Rev Immunol 33:29\u201348. https:\/\/doi.org\/10.1146\/annurev-immunol-032414-112110","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"838_CR16","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.4049\/jimmunol.175.4.2438","volume":"175","author":"MJ Turner","year":"2005","unstructured":"Turner MJ, Sowders DP, DeLay ML, Mohapatra R, Bai S, Smith JA et al (2005) HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol 175(4):2438\u20132448","journal-title":"J Immunol"},{"issue":"41","key":"838_CR17","doi-asserted-by":"publisher","first-page":"17698","DOI":"10.1073\/pnas.1011736107","volume":"107","author":"JC Goodall","year":"2010","unstructured":"Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L, Saudek V, Gaston JSH (2010) Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 107(41):17698\u201317703. https:\/\/doi.org\/10.1073\/pnas.1011736107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"838_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nu\u00f1ez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 411:603\u2013606","journal-title":"Nature."},{"issue":"4","key":"838_CR19","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.4049\/jimmunol.1002653","volume":"186","author":"P Bowness","year":"2011","unstructured":"Bowness P, Ridley A, Shaw J, Chan AT, Wong-Baeza I, Fleming M, Cummings F, McMichael A, Kollnberger S (2011) Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J Immunol 186(4):2672\u20132680. https:\/\/doi.org\/10.4049\/jimmunol.1002653","journal-title":"J Immunol"},{"issue":"3","key":"838_CR20","doi-asserted-by":"publisher","first-page":"R95","DOI":"10.1186\/ar3370","volume":"13","author":"H Appel","year":"2011","unstructured":"Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J (2011) Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 13(3):R95. https:\/\/doi.org\/10.1186\/ar3370","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"838_CR21","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1002\/art.37937","volume":"65","author":"H Appel","year":"2013","unstructured":"Appel H, Maier R, Bleil J, Hempfing A, Loddenkemper C, Schlichting U, Syrbe U, Sieper J (2013) In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum 65(6):1522\u20131529. https:\/\/doi.org\/10.1002\/art.37937","journal-title":"Arthritis Rheum"},{"issue":"12","key":"838_CR22","doi-asserted-by":"publisher","first-page":"5357","DOI":"10.1172\/JCI125212","volume":"129","author":"CH Liu","year":"2019","unstructured":"Liu CH, Raj S, Chen CH, Hung KH, Chou CT, Chen IH, Chien JT, Lin IY, Yang SY, Angata T, Tsai WC, Wei JCC, Tzeng IS, Hung SC, Lin KI (2019) HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis. J Clin Invest 129(12):5357\u20135373. https:\/\/doi.org\/10.1172\/JCI125212","journal-title":"J Clin Invest"},{"key":"838_CR23","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.4049\/jimmunol.163.12.6665","volume":"163","author":"JP Mear","year":"1999","unstructured":"Mear JP, Schreiber KL, Munz C, Zhu X, Stevanovic S, Rammensee H-G et al (1999) Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 163:6665\u20136670","journal-title":"J Immunol"},{"issue":"5","key":"838_CR24","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1073\/pnas.1016229108","volume":"108","author":"ML Burr","year":"2011","unstructured":"Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ (2011) HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A 108(5):2034\u20132039. https:\/\/doi.org\/10.1073\/pnas.1016229108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"838_CR25","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1002\/art.38809","volume":"66","author":"DB Guiliano","year":"2014","unstructured":"Guiliano DB, Fussell H, Lenart I, Tsao E, Nesbeth D, Fletcher AJ, Campbell EC, Yousaf N, Williams S, Santos S, Cameron A, Towers GJ, Kellam P, Hebert DN, Gould KG, Powis SJ, Antoniou AN (2014) Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis & rheumatology. 66(11):2976\u20132988. https:\/\/doi.org\/10.1002\/art.38809","journal-title":"Arthritis & rheumatology."},{"issue":"1","key":"838_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrrheum.2016.192","volume":"13","author":"F Navid","year":"2017","unstructured":"Navid F, Colbert RA (2017) Causes and consequences of endoplasmic reticulum stress in rheumatic disease. Nat Rev Rheumatol 13(1):25\u201340. https:\/\/doi.org\/10.1038\/nrrheum.2016.192","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"838_CR27","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/art.40414","volume":"70","author":"F Navid","year":"2018","unstructured":"Navid F, Layh-Schmitt G, Sikora KA, Cougnoux A, Colbert RA (2018) The role of autophagy in the degradation of misfolded HLA-B27 heavy chains. Arthritis & rheumatology. 70(5):746\u2013755. https:\/\/doi.org\/10.1002\/art.40414","journal-title":"Arthritis & rheumatology."},{"issue":"8","key":"838_CR28","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1002\/art.38644","volume":"66","author":"C Jeanty","year":"2014","unstructured":"Jeanty C, Sourisce A, Noteuil A, Jah N, Wielgosik A, Fert I, Breban M, Andr\u00e9 C (2014) HLA-B27 subtype oligomerization and intracellular accumulation patterns correlate with predisposition to spondyloarthritis. Arthritis & rheumatology. 66(8):2113\u20132123. https:\/\/doi.org\/10.1002\/art.38644","journal-title":"Arthritis & rheumatology."},{"key":"838_CR29","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/art.41281","volume":"72","author":"N Jah","year":"2020","unstructured":"Jah N, Jobart-Malfait A, Ermoza K, Noteuil A, Chiocchia G, Breban M, Andr\u00e9 C (2020) HLA-B27 subtypes predisposing to ankylosing spondylitis accumulate in an endoplasmic reticulum-derived compartment apart from the peptide-loading complex. Arthritis & rheumatology. 72:1534\u20131546. https:\/\/doi.org\/10.1002\/art.41281","journal-title":"Arthritis & rheumatology."},{"key":"838_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1399-0039.1995.tb02436.x","volume":"45","author":"C Lopez-Larrea","year":"1995","unstructured":"Lopez-Larrea C, Sujirachato K, Mehra NK, Chiewsilp P, Isarangkura D, Kanga U et al (1995) HLA-B27 subtypes in Asian patients with ankylosing spondylitis: evidence for new associations. Tissue Antigens 45:169\u2013176","journal-title":"Tissue Antigens"},{"key":"838_CR31","first-page":"1111","volume":"24","author":"AR Nasution","year":"1997","unstructured":"Nasution AR, Mardjuadi A, Kunmartini S, Suryadhana NG, Setyohadi B, Sudarsono D, Lardy NM, Feltkamp TE (1997) HLA-B27 subtypes positively and negatively associated with spondyloarthropathy. J Rheumatol 24:1111\u20131114","journal-title":"J Rheumatol"},{"key":"838_CR32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","volume":"27","author":"SL Masters","year":"2009","unstructured":"Masters SL, Simon A, Aksentijevich I, Kastner DL (2009) Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 27:621\u2013668. https:\/\/doi.org\/10.1146\/annurev.immunol.25.022106.141627","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"838_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030297","volume":"3","author":"D McGonagle","year":"2006","unstructured":"McGonagle D, McDermott MF (2006) A proposed classification of the immunological diseases. PLoS Med 3(8):e297. https:\/\/doi.org\/10.1371\/journal.pmed.0030297","journal-title":"PLoS Med"},{"key":"838_CR34","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4049\/jimmunol.156.2.794","volume":"156","author":"M Breban","year":"1996","unstructured":"Breban M, Fernandez-Sueiro JL, Richardson JA, Hadavand RR, Maika SD, Hammer RE et al (1996) T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 156:794\u2013803","journal-title":"J Immunol"},{"key":"838_CR35","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ebiom.2019.07.032","volume":"47","author":"M Zheng","year":"2019","unstructured":"Zheng M, Zhang X, Zhou Y, Tang J, Han Q, Zhang Y, Ni Q, Chen G, Jia Q, Yu H, Liu S, Robins E, Jiang NJ, Wan Y, Li QJ, Chen ZN, Zhu P (2019) TCR repertoire and CDR3 motif analyses depict the role of alphabeta T cells in Ankylosing spondylitis. EBioMedicine. 47:414\u2013426. https:\/\/doi.org\/10.1016\/j.ebiom.2019.07.032","journal-title":"EBioMedicine."},{"key":"838_CR36","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.4049\/jimmunol.167.5.2619","volume":"167","author":"LH Boyle","year":"2001","unstructured":"Boyle LH, Goodall JC, Opat SS, Gaston JSH (2001) The recognition of HLA-B27 by human CD4+ T lymphocytes. J Immunol 167:2619\u20132624","journal-title":"J Immunol"},{"issue":"4","key":"838_CR37","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/art.40028","volume":"69","author":"M Faham","year":"2017","unstructured":"Faham M, Carlton V, Moorhead M, Zheng J, Klinger M, Pepin F, Asbury T, Vignali M, Emerson RO, Robins HS, Ireland J, Baechler-Gillespie E, Inman RD (2017) Discovery of T cell receptor beta motifs specific to HLA-B27-positive ankylosing spondylitis by deep repertoire sequence analysis. Arthritis & rheumatology. 69(4):774\u2013784. https:\/\/doi.org\/10.1002\/art.40028","journal-title":"Arthritis & rheumatology."},{"issue":"8","key":"838_CR38","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/art.41252","volume":"72","author":"AL Hanson","year":"2020","unstructured":"Hanson AL, Nel HJ, Bradbury L, Phipps J, Thomas R, Le Cao KA et al (2020) Altered repertoire diversity and disease-associated clonal expansions revealed by T cell receptor immunosequencing in ankylosing spondylitis patients. Arthritis & rheumatology. 72(8):1289\u20131302. https:\/\/doi.org\/10.1002\/art.41252","journal-title":"Arthritis & rheumatology."},{"issue":"4","key":"838_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1034\/j.1399-0039.2002.600404.x","volume":"60","author":"E May","year":"2002","unstructured":"May E, Dulphy N, Frauendorf E, Duchmann R, Bowness P, Lopez de Castro JA et al (2002) Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. Tissue Antigens 60(4):299\u2013308","journal-title":"Tissue Antigens"},{"issue":"3","key":"838_CR40","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/art.10847","volume":"48","author":"J Zou","year":"2003","unstructured":"Zou J, Rudwaleit M, Brandt J, Thiel A, Braun J, Sieper J (2003) Down-regulation of the nonspecific and antigen-specific T cell cytokine response in ankylosing spondylitis during treatment with infliximab. Arthritis Rheum 48(3):780\u2013790","journal-title":"Arthritis Rheum"},{"issue":"4","key":"838_CR41","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/art.38318","volume":"66","author":"I Fert","year":"2014","unstructured":"Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M (2014) Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis. Arthritis & rheumatology. 66(4):841\u2013851. https:\/\/doi.org\/10.1002\/art.38318","journal-title":"Arthritis & rheumatology."},{"issue":"6","key":"838_CR42","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1002\/art.23512","volume":"58","author":"JA Smith","year":"2008","unstructured":"Smith JA, Barnes MD, Hong D, DeLay ML, Inman RD, Colbert RA (2008) Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. Arthritis Rheum 58(6):1640\u20131649","journal-title":"Arthritis Rheum"},{"key":"838_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1136\/ard.60.1.36","volume":"60","author":"M Rudwaleit","year":"2001","unstructured":"Rudwaleit M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A, Sieper J, Braun J (2001) Low T cell production of TNFa and IFN g in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis 60:36\u201342","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"838_CR44","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1136\/ard.62.6.561","volume":"62","author":"J Zou","year":"2003","unstructured":"Zou J, Rudwaleit M, Brandt J, Thiel A, Braun J, Sieper J (2003) Up regulation of the production of tumour necrosis factor alpha and interferon gamma by T cells in ankylosing spondylitis during treatment with etanercept. Ann Rheum Dis 62(6):561\u2013564","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"838_CR45","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1002\/art.30558","volume":"63","author":"JT Rosenbaum","year":"2011","unstructured":"Rosenbaum JT, Davey MP (2011) Time for a gut check: evidence for the hypothesis that HLA-B27 predisposes to ankylosing spondylitis by altering the microbiome. Arthritis Rheum 63(11):3195\u20133198. https:\/\/doi.org\/10.1002\/art.30558","journal-title":"Arthritis Rheum"},{"issue":"8","key":"838_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105684","volume":"9","author":"P Lin","year":"2014","unstructured":"Lin P, Bach M, Asquith M, Lee AY, Akileswaran L, Stauffer P, Davin S, Pan Y, Cambronne ED, Dorris M, Debelius JW, Lauber CL, Ackermann G, Baeza YV, Gill T, Knight R, Colbert RA, Taurog JD, van Gelder RN, Rosenbaum JT (2014) HLA-B27 and human beta2-microglobulin affect the gut microbiota of transgenic rats. PLoS One 9(8):e105684. https:\/\/doi.org\/10.1371\/journal.pone.0105684","journal-title":"PLoS One"},{"issue":"4","key":"838_CR47","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/art.40405","volume":"70","author":"T Gill","year":"2018","unstructured":"Gill T, Asquith M, Brooks SR, Rosenbaum JT, Colbert RA (2018) Effects of HLA-B27 on gut microbiota in experimental spondyloarthritis implicate an ecological model of dysbiosis. Arthritis & rheumatology. 70(4):555\u2013565. https:\/\/doi.org\/10.1002\/art.40405","journal-title":"Arthritis & rheumatology."},{"issue":"11","key":"838_CR48","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1002\/art.41018","volume":"71","author":"T Gill","year":"2019","unstructured":"Gill T, Brooks SR, Rosenbaum JT, Asquith M, Colbert RA (2019) Novel inter-omic analysis reveals relationships between diverse gut microbiota and host immune dysregulation in HLA-B27-induced experimental spondyloarthritis. Arthritis & rheumatology. 71(11):1849\u20131857. https:\/\/doi.org\/10.1002\/art.41018","journal-title":"Arthritis & rheumatology."},{"issue":"10","key":"838_CR49","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1002\/art.40183","volume":"69","author":"M Asquith","year":"2017","unstructured":"Asquith M, Davin S, Stauffer P, Michell C, Janowitz C, Lin P, Ensign-Lewis J, Kinchen JM, Koop DR, Rosenbaum JT (2017) Intestinal metabolites are profoundly altered in the context of HLA-B27 expression and functionally modulate disease in a rat model of spondyloarthritis. Arthritis & rheumatology. 69(10):1984\u20131995. https:\/\/doi.org\/10.1002\/art.40183","journal-title":"Arthritis & rheumatology."},{"issue":"9","key":"838_CR50","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/art.39681","volume":"68","author":"MJ Asquith","year":"2016","unstructured":"Asquith MJ, Stauffer P, Davin S, Mitchell C, Lin P, Rosenbaum JT (2016) Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis. Arthritis & rheumatology. 68(9):2151\u20132162. https:\/\/doi.org\/10.1002\/art.39681","journal-title":"Arthritis & rheumatology."},{"issue":"10","key":"838_CR51","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1002\/art.40917","volume":"71","author":"M Asquith","year":"2019","unstructured":"Asquith M, Sternes PR, Costello ME, Karstens L, Diamond S, Martin TM, Li Z, Marshall MS, Spector TD, Cao KA, Rosenbaum JT, Brown MA (2019) HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome. Arthritis & rheumatology. 71(10):1642\u20131650. https:\/\/doi.org\/10.1002\/art.40917","journal-title":"Arthritis & rheumatology."},{"issue":"12","key":"838_CR52","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1136\/annrheumdis-2019-215832","volume":"78","author":"B Grandon","year":"2019","unstructured":"Grandon B, Rincheval-Arnold A, Jah N, Corsi JM, Araujo LM, Glatigny S, Prevost E, Roche D, Chiocchia G, Gu\u00e9nal I, Gaumer S, Breban M (2019) HLA-B27 alters BMP\/TGFbeta signalling in Drosophila, revealing putative pathogenic mechanism for spondyloarthritis. Ann Rheum Dis 78(12):1653\u20131662. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215832","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"838_CR53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1272\/jnms.77.4","volume":"77","author":"H Orimo","year":"2010","unstructured":"Orimo H (2010) The mechanism of mineralization and the role of alkaline phosphatase in health and disease. J Nippon Med Sch 77(1):4\u201312. https:\/\/doi.org\/10.1272\/jnms.77.4","journal-title":"J Nippon Med Sch"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00838-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00281-021-00838-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00838-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:47:17Z","timestamp":1697651237000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00281-021-00838-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["838"],"URL":"https:\/\/doi.org\/10.1007\/s00281-021-00838-z","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"4 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}