{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:56:29Z","timestamp":1788537389550,"version":"build-2803163510"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB841"],"award-info":[{"award-number":["SFB841"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Research Funding, Hamburg","award":["LFF-FV45"],"award-info":[{"award-number":["LFF-FV45"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver disorders due to infections are a substantial health concern in underdeveloped and industrialized countries. This includes not only hepatotropic viruses (e.g., hepatitis B, hepatitis C) but also bacterial and parasitic infections such as amebiasis, leishmaniasis, schistosomiasis, or echinococcosis. Recent studies of the immune mechanisms underlying liver disease show that monocytes play an essential role in determining patient outcomes. Monocytes are derived from the mononuclear phagocyte lineage in the bone marrow and are present in nearly all tissues of the body; these cells function as part of the early innate immune response that reacts to challenge by external pathogens. Due to their special ability to develop into tissue macrophages and dendritic cells and to change from an inflammatory to an anti-inflammatory phenotype, monocytes play a pivotal role in infectious and non-infectious liver diseases: they can maintain inflammation and support resolution of inflammation. Therefore, tight regulation of monocyte recruitment and termination of monocyte-driven immune responses in the liver is prerequisite to appropriate healing of organ damage. In this review, we discuss monocyte-dependent immune mechanisms underlying hepatic infectious disorders. Better understanding of these immune mechanisms may lead to development of new interventions to treat acute liver disease and prevent progression to organ failure.<\/jats:p>","DOI":"10.1007\/s00281-021-00852-1","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T17:03:29Z","timestamp":1617815009000},"page":"493-506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Monocyte dysregulation: consequences for hepatic infections"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-4823","authenticated-orcid":false,"given":"Julie","family":"Sellau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-6127","authenticated-orcid":false,"given":"Tobias","family":"Puengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-8847","authenticated-orcid":false,"given":"Stefan","family":"Hoenow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4995-0176","authenticated-orcid":false,"given":"Marie","family":"Groneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-0229","authenticated-orcid":false,"given":"Hannelore","family":"Lotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"issue":"2","key":"852_CR1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","volume":"13","author":"F Heymann","year":"2016","unstructured":"Heymann F, Tacke F (2016) Immunology in the liver--from homeostasis to disease. Nat Rev Gastroenterol Hepatol 13(2):88\u2013110","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"852_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrgastro.2016.168","volume":"14","author":"P Strnad","year":"2017","unstructured":"Strnad P, Tacke F, Koch A, Trautwein C (2017) Liver - guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol 14(1):55\u201366","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"852_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","volume":"36","author":"P Kubes","year":"2018","unstructured":"Kubes P, Jenne C (2018) Immune responses in the liver. Annu Rev Immunol 36(1):247\u2013277","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"852_CR4","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","volume":"60","author":"F Tacke","year":"2014","unstructured":"Tacke F, Zimmermann HW (2014) Macrophage heterogeneity in liver injury and fibrosis. J Hepatol 60(5):1090\u20131096","journal-title":"J Hepatol"},{"issue":"1","key":"852_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.chom.2016.06.002","volume":"20","author":"Z Zeng","year":"2016","unstructured":"Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P (2016) CRIg Functions as a macrophage pattern recognition receptor to directly bind and capture blood-borne gram-positive bacteria. Cell Host Microbe 20(1):99\u2013106","journal-title":"Cell Host Microbe"},{"issue":"10","key":"852_CR6","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ni.2691","volume":"14","author":"CN Jenne","year":"2013","unstructured":"Jenne CN, Kubes P (2013) Immune surveillance by the liver. Nat Immunol 14(10):996\u20131006","journal-title":"Nat Immunol"},{"issue":"3","key":"852_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41419-018-0377-4","volume":"9","author":"L Su","year":"2018","unstructured":"Su L, Li N, Tang H, Lou Z, Chong X, Zhang C, Su J, Dong X (2018) Kupffer cell-derived TNF-alpha promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells. Cell Death Dis 9(3):323","journal-title":"Cell Death Dis"},{"issue":"11","key":"852_CR8","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1038\/cti.2016.62","volume":"5","author":"KJ Brempelis","year":"2016","unstructured":"Brempelis KJ, Crispe IN (2016) Infiltrating monocytes in liver injury and repair. Clin Transl Immunol 5(11):e113","journal-title":"Clin Transl Immunol"},{"key":"852_CR9","doi-asserted-by":"publisher","first-page":"10321","DOI":"10.1038\/ncomms10321","volume":"7","author":"CL Scott","year":"2016","unstructured":"Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A, Guilliams M (2016) Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nat Commun 7:10321","journal-title":"Nat Commun"},{"issue":"6","key":"852_CR10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri.2017.28","volume":"17","author":"CV Jakubzick","year":"2017","unstructured":"Jakubzick CV, Randolph GJ, Henson PM (2017) Monocyte differentiation and antigen-presenting functions. Nat Rev Immunol 17(6):349\u2013362","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"852_CR11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ni1309","volume":"7","author":"NV Serbina","year":"2006","unstructured":"Serbina NV, Pamer EG (2006) Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 7(3):311\u2013317","journal-title":"Nat Immunol"},{"issue":"11","key":"852_CR12","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11(11):762\u2013774","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"852_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1556\/EuJMI.2.2012.2.1","volume":"2","author":"KR Karlmark","year":"2012","unstructured":"Karlmark KR, Tacke F, Dunay IR (2012) Monocytes in health and disease - Minireview. Eur J Microbiol Immunol (Bp) 2(2):97\u2013102","journal-title":"Eur J Microbiol Immunol (Bp)"},{"issue":"3","key":"852_CR14","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","volume":"44","author":"TA Wynn","year":"2016","unstructured":"Wynn TA, Vannella KM (2016) Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44(3):450\u2013462","journal-title":"Immunity"},{"issue":"5","key":"852_CR15","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.immuni.2017.04.018","volume":"46","author":"A Mildner","year":"2017","unstructured":"Mildner A, Schonheit J, Giladi A, David E, Lara-Astiaso D, Lorenzo-Vivas E, Paul F, Chappell-Maor L, Priller J, Leutz A, Amit I, Jung S (2017) Genomic characterization of murine monocytes reveals C\/EBPbeta transcription factor dependence of Ly6C(-) cells. Immunity 46(5):849\u2013862 e7","journal-title":"Immunity"},{"issue":"4","key":"852_CR16","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","volume":"49","author":"M Guilliams","year":"2018","unstructured":"Guilliams M, Mildner A, Yona S (2018) Developmental and functional heterogeneity of monocytes. Immunity 49(4):595\u2013613","journal-title":"Immunity"},{"key":"852_CR17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1146\/annurev.immunol.021908.132557","volume":"27","author":"C Auffray","year":"2009","unstructured":"Auffray C, Sieweke MH, Geissmann F (2009) Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 27:669\u2013692","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"852_CR18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","volume":"19","author":"F Geissmann","year":"2003","unstructured":"Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71\u201382","journal-title":"Immunity"},{"key":"852_CR19","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3389\/fimmu.2020.01117","volume":"11","author":"A Meghraoui-Kheddar","year":"2020","unstructured":"Meghraoui-Kheddar A, Barthelemy S, Boissonnas A, Combadi\u00e8re C (2020) Revising CX3CR1 expression on murine classical and non-classical monocytes. Front Immunol 11:1117","journal-title":"Front Immunol"},{"issue":"11","key":"852_CR20","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","volume":"20","author":"S Jung","year":"2000","unstructured":"Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR (2000) Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106\u20134114","journal-title":"Mol Cell Biol"},{"key":"852_CR21","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fcimb.2013.00032","volume":"3","author":"I Zanoni","year":"2013","unstructured":"Zanoni I, Granucci F (2013) Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol 3:32","journal-title":"Front Cell Infect Microbiol"},{"key":"852_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","volume":"20","author":"CA Janeway Jr","year":"2002","unstructured":"Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197\u2013216","journal-title":"Annu Rev Immunol"},{"issue":"16","key":"852_CR23","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","volume":"116","author":"L Ziegler-Heitbrock","year":"2010","unstructured":"Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB (2010) Nomenclature of monocytes and dendritic cells in blood. Blood 116(16):e74\u2013e80","journal-title":"Blood"},{"issue":"4","key":"852_CR24","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.20141539","volume":"212","author":"D Dal-Secco","year":"2015","unstructured":"Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, Ransohoff RM, Charo IF, Jenne CN, Kubes P (2015) A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med 212(4):447\u2013456","journal-title":"J Exp Med"},{"issue":"3","key":"852_CR25","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1182\/blood-2009-07-235028","volume":"115","author":"MA Ingersoll","year":"2010","unstructured":"Ingersoll MA, Spanbroek R, Lottaz C, Gautier EL, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht AJ, Ziegler-Heitbrock L, Randolph GJ (2010) Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115(3):e10\u2013e19","journal-title":"Blood"},{"issue":"5","key":"852_CR26","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41590-020-0661-1","volume":"21","author":"A Giladi","year":"2020","unstructured":"Giladi A, Wagner LK, Li H, Dorr D, Medaglia C, Paul F, Shemer A, Jung S, Yona S, Mack M, Leutz A, Amit I, Mildner A (2020) Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation. Nat Immunol 21(5):525\u2013534","journal-title":"Nat Immunol"},{"issue":"4","key":"852_CR27","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1172\/JCI29919","volume":"117","author":"CL Tsou","year":"2007","unstructured":"Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, Mack M, Charo IF (2007) Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117(4):902\u2013909","journal-title":"J Clin Invest"},{"issue":"10","key":"852_CR28","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.4049\/jimmunol.180.10.6846","volume":"180","author":"T Jia","year":"2008","unstructured":"Jia T, Serbina NV, Brandl K, Zhong MX, Leiner IM, Charo IF, Pamer EG (2008) Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol 180(10):6846\u20136853","journal-title":"J Immunol"},{"key":"852_CR29","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1186\/s12879-014-0621-1","volume":"14","author":"H Bernin","year":"2014","unstructured":"Bernin H, Marggraff C, Jacobs T, Brattig N, Le VA, Blessmann J, Lotter H (2014) Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex. BMC Infect Dis 14:621","journal-title":"BMC Infect Dis"},{"issue":"10","key":"852_CR30","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1172\/JCI119798","volume":"100","author":"L Boring","year":"1997","unstructured":"Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV Jr, Broxmeyer HE, Charo IF (1997) Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 100(10):2552\u20132561","journal-title":"J Clin Invest"},{"issue":"22","key":"852_CR31","doi-asserted-by":"publisher","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","volume":"94","author":"WA Kuziel","year":"1997","unstructured":"Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, Maeda N (1997) Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A 94(22):12053\u201312058","journal-title":"Proc Natl Acad Sci U S A"},{"key":"852_CR32","doi-asserted-by":"crossref","unstructured":"Zimmermann H, Trautwein C, Tacke F (2012) Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front Physiol 3(56)","DOI":"10.3389\/fphys.2012.00056"},{"issue":"1","key":"852_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","volume":"19","author":"NV Serbina","year":"2003","unstructured":"Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG (2003) TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19(1):59\u201370","journal-title":"Immunity"},{"issue":"14","key":"852_CR34","doi-asserted-by":"publisher","first-page":"7958","DOI":"10.1073\/pnas.131207398","volume":"98","author":"W Peters","year":"2001","unstructured":"Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD (2001) Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 98(14):7958\u20137963","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"852_CR35","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","volume":"29","author":"IR Dunay","year":"2008","unstructured":"Dunay IR, Damatta RA, Fux B, Presti R, Greco S, Colonna M, Sibley LD (2008) Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity 29(2):306\u2013317","journal-title":"Immunity"},{"issue":"2","key":"852_CR36","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1128\/IAI.01314-06","volume":"75","author":"SM Conrad","year":"2007","unstructured":"Conrad SM, Strauss-Ayali D, Field AE, Mack M, Mosser DM (2007) Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages. Infect Immun 75(2):653\u2013665","journal-title":"Infect Immun"},{"issue":"27","key":"852_CR37","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1182\/blood-2009-04-217489","volume":"114","author":"AM Sponaas","year":"2009","unstructured":"Sponaas AM, do Rosario APF, Voisine C, Mastelic B, Thompson J, Koernig S, Jarra W, Renia L, Mauduit M, Potocnik AJ, Langhorne J (2009) Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood 114(27):5522\u20135531","journal-title":"Blood"},{"key":"852_CR38","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/1742-2094-9-270","volume":"9","author":"RL Terry","year":"2012","unstructured":"Terry RL, Getts DR, Deffrasnes C, van Vreden C, Campbell IL, King NJ (2012) Inflammatory monocytes and the pathogenesis of viral encephalitis. J Neuroinflammation 9:270","journal-title":"J Neuroinflammation"},{"issue":"8","key":"852_CR39","doi-asserted-by":"publisher","first-page":"e1001045","DOI":"10.1371\/journal.ppat.1001045","volume":"6","author":"T Bosschaerts","year":"2010","unstructured":"Bosschaerts T, Guilliams M, Stijlemans B, Morias Y, Engel D, Tacke F, H\u00e9rin M, De Baetselier P, Beschin A (2010) Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2\/CCR2, IFN-gamma and MyD88 signaling. PLoS Pathog 6(8):e1001045","journal-title":"PLoS Pathog"},{"issue":"1","key":"852_CR40","doi-asserted-by":"publisher","first-page":"e1003096","DOI":"10.1371\/journal.ppat.1003096","volume":"9","author":"E Helk","year":"2013","unstructured":"Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H (2013) TNFalpha-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. PLoS Pathog 9(1):e1003096","journal-title":"PLoS Pathog"},{"issue":"7","key":"852_CR41","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.4049\/jimmunol.1701543","volume":"200","author":"BM Coates","year":"2018","unstructured":"Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM (2018) Inflammatory monocytes drive influenza a virus-mediated lung injury in juvenile mice. J Immunol 200(7):2391\u20132404","journal-title":"J Immunol"},{"issue":"10","key":"852_CR42","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.4049\/jimmunol.1601896","volume":"198","author":"R Channappanavar","year":"2017","unstructured":"Channappanavar R, Fett C, Mack M, Ten Eyck PP, Meyerholz DK, Perlman S (2017) Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection. J Immunol 198(10):4046\u20134053","journal-title":"J Immunol"},{"issue":"6","key":"852_CR43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","volume":"20","author":"M Merad","year":"2020","unstructured":"Merad M, Martin JC (2020) Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol 20(6):355\u2013362","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"852_CR44","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1161\/ATVBAHA.108.173898","volume":"28","author":"AC Newby","year":"2008","unstructured":"Newby AC (2008) Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol 28(12):2108\u20132114","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"852_CR45","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/sj.jhh.1001990","volume":"20","author":"T Watanabe","year":"2006","unstructured":"Watanabe T, Yasunari K, Nakamura M, Maeda K (2006) Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients. J Hum Hypertens 20(5):336\u2013340","journal-title":"J Hum Hypertens"},{"key":"852_CR46","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.3389\/fimmu.2018.02948","volume":"9","author":"E Triantafyllou","year":"2018","unstructured":"Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG, Possamai LA (2018) The role of monocytes and macrophages in acute and acute-on-chronic liver failure. Front Immunol 9:2948","journal-title":"Front Immunol"},{"issue":"4","key":"852_CR47","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1365-3024.2005.00754.x","volume":"27","author":"C Maldonado-Bernal","year":"2005","unstructured":"Maldonado-Bernal C, Kirschning CJ, Rosenstein Y, Rocha LM, Rios-Sarabia N, Espinosa-Cantellano M, Becker I, Estrada I, Salazar-Gonz\u00e1lez RM, L\u00f3pez-Mac\u00edas C, Wagner H, S\u00e1nchez J, Isibasi A (2005) The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4. Parasite Immunol 27(4):127\u2013137","journal-title":"Parasite Immunol"},{"issue":"1","key":"852_CR48","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1038\/s41467-020-17260-y","volume":"11","author":"J Sellau","year":"2020","unstructured":"Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H (2020) Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. Nat Commun 11(1):3459","journal-title":"Nat Commun"},{"issue":"1","key":"852_CR49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"PJ Murray","year":"2014","unstructured":"Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA (2014) Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41(1):14\u201320","journal-title":"Immunity"},{"issue":"2","key":"852_CR50","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","volume":"40","author":"J Xue","year":"2014","unstructured":"Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL (2014) Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40(2):274\u2013288","journal-title":"Immunity"},{"issue":"3","key":"852_CR51","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/gutjnl-2019-318382","volume":"69","author":"O Krenkel","year":"2020","unstructured":"Krenkel O, Hundertmark J, Abdallah AT, Kohlhepp M, Puengel T, Roth T, Branco DPP, Mossanen JC, Luedde T, Trautwein C, Costa IG, Tacke F (2020) Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. Gut 69(3):551\u2013563","journal-title":"Gut"},{"issue":"10","key":"852_CR52","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/ni.2705","volume":"14","author":"LC Davies","year":"2013","unstructured":"Davies LC, Jenkins SJ, Allen JE, Taylor PR (2013) Tissue-resident macrophages. Nat Immunol 14(10):986\u2013995","journal-title":"Nat Immunol"},{"key":"852_CR53","doi-asserted-by":"publisher","first-page":"949157","DOI":"10.1155\/2012\/949157","volume":"2012","author":"E Liaskou","year":"2012","unstructured":"Liaskou E, Wilson DV, Oo YH (2012) Innate immune cells in liver inflammation. Mediat Inflamm 2012:949157","journal-title":"Mediat Inflamm"},{"key":"852_CR54","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.3389\/fimmu.2019.02852","volume":"10","author":"D van der Heide","year":"2019","unstructured":"van der Heide D, Weiskirchen R, Bansal R (2019) Therapeutic targeting of hepatic macrophages for the treatment of liver diseases. Front Immunol 10:2852","journal-title":"Front Immunol"},{"issue":"4","key":"852_CR55","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/hep.29544","volume":"67","author":"O Krenkel","year":"2018","unstructured":"Krenkel O, Puengel T, Govaere O, Abdallah AT, Mossanen JC, Kohlhepp M, Liepelt A, Lefebvre E, Luedde T, Hellerbrand C, Weiskirchen R, Longerich T, Costa IG, Anstee QM, Trautwein C, Tacke F (2018) Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis. Hepatology 67(4):1270\u20131283","journal-title":"Hepatology"},{"issue":"1","key":"852_CR56","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cld.2010.09.002","volume":"15","author":"R Talwani","year":"2011","unstructured":"Talwani R, Gilliam BL, Howell C (2011) Infectious diseases and the liver. Clin Liver Dis 15(1):111\u2013130","journal-title":"Clin Liver Dis"},{"key":"852_CR57","volume-title":"Liver Diseases","author":"Y Hawash","year":"2020","unstructured":"Hawash Y (2020) Parasitic liver disease. In: Radu-Ionita PNF, Jinga M, Tintoui I, Su Z, Bontas E (eds) Liver Diseases. Springer, Cham"},{"issue":"7","key":"852_CR58","doi-asserted-by":"publisher","first-page":"ofy161","DOI":"10.1093\/ofid\/ofy161","volume":"5","author":"DT Shirley","year":"2018","unstructured":"Shirley DT, Farr L, Watanabe K, Moonah S (2018) A review of the global burden, new diagnostics, and current therapeutics for amebiasis. Open Forum Infect Dis 5(7):ofy161","journal-title":"Open Forum Infect Dis"},{"key":"852_CR59","volume-title":"Amebiasis","author":"H Zulfiqar","year":"2020","unstructured":"Zulfiqar H, Mathew G, Horrall S (2020) Amebiasis. StatPearls, Treasure Island (FL)"},{"issue":"15","key":"852_CR60","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.micinf.2012.05.013","volume":"14","author":"DM Faust","year":"2012","unstructured":"Faust DM, Guillen N (2012) Virulence and virulence factors in Entamoeba histolytica, the agent of human amoebiasis. Microbes Infect 14(15):1428\u20131441","journal-title":"Microbes Infect"},{"issue":"5","key":"852_CR61","doi-asserted-by":"publisher","first-page":"578","DOI":"10.4269\/ajtmh.2002.66.578","volume":"66","author":"J Blessmann","year":"2002","unstructured":"Blessmann J, Van Linh P, Nu PA, Thi HD, Muller-Myhsok B, Buss H, Tannich E (2002) Epidemiology of amebiasis in a region of high incidence of amebic liver abscess in central Vietnam. Am J Trop Med Hyg 66(5):578\u2013583","journal-title":"Am J Trop Med Hyg"},{"issue":"10","key":"852_CR62","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1365-3024.2003.00662.x","volume":"25","author":"J Ventura-Juarez","year":"2003","unstructured":"Ventura-Juarez J, Jarillo-Luna RA, Fuentes-Aguilar E, Pineda-Vazquez A, Munoz-Fernandez L, Madrid-Reyes JI, Campos-Rodriguez R (2003) Human amoebic hepatic abscess: in situ interactions between trophozoites, macrophages, neutrophils and T cells. Parasite Immunol 25(10):503\u2013511","journal-title":"Parasite Immunol"},{"issue":"1","key":"852_CR63","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1128\/IAI.74.1.118-124.2006","volume":"74","author":"H Lotter","year":"2006","unstructured":"Lotter H, Jacobs T, Gaworski I, Tannich E (2006) Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease. Infect Immun 74(1):118\u2013124","journal-title":"Infect Immun"},{"issue":"5","key":"852_CR64","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.jhep.2016.01.013","volume":"64","author":"J Noll","year":"2016","unstructured":"Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrucker HW, Holscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H (2016) IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage. J Hepatol 64(5):1147\u20131157","journal-title":"J Hepatol"},{"issue":"2","key":"852_CR65","doi-asserted-by":"publisher","first-page":"788","DOI":"10.4049\/jimmunol.175.2.788","volume":"175","author":"SA Khader","year":"2005","unstructured":"Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM (2005) IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 175(2):788\u2013795","journal-title":"J Immunol"},{"issue":"12","key":"852_CR66","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1128\/IAI.00589-12","volume":"80","author":"M Indramohan","year":"2012","unstructured":"Indramohan M, Sieve AN, Break TJ, Berg RE (2012) Inflammatory monocyte recruitment is regulated by interleukin-23 during systemic bacterial infection. Infect Immun 80(12):4099\u20134105","journal-title":"Infect Immun"},{"issue":"8","key":"852_CR67","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1128\/CVI.00129-08","volume":"15","author":"NJ Kotloski","year":"2008","unstructured":"Kotloski NJ, Nardelli DT, Peterson SH, Torrealba JR, Warner TF, Callister SM, Schell RF (2008) Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species. Clin Vaccine Immunol 15(8):1199\u20131207","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"852_CR68","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1096\/fj.03-0578fje","volume":"18","author":"SJ Kammanadiminti","year":"2004","unstructured":"Kammanadiminti SJ, Mann BJ, Dutil L, Chadee K (2004) Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolytica. FASEB J 18(1):155\u2013157","journal-title":"FASEB J"},{"issue":"26","key":"852_CR69","doi-asserted-by":"publisher","first-page":"12175","DOI":"10.1073\/pnas.92.26.12175","volume":"92","author":"R Seguin","year":"1995","unstructured":"Seguin R, Mann BJ, Keller K, Chadee K (1995) Identification of the galactose-adherence lectin epitopes of Entamoeba histolytica that stimulate tumor necrosis factor-alpha production by macrophages. Proc Natl Acad Sci U S A 92(26):12175\u201312179","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 1","key":"852_CR70","first-page":"175","volume":"21","author":"A Isibasi","year":"1990","unstructured":"Isibasi A, Blanco F, Arreguin C, Martinez G, Pelayo R, Orozco E, Kumate J (1990) Immunochemical differences in the surface polysaccharides obtained from Entamoeba histolytica strain HM1:IMSS and its virulent (C-A) and non-virulent (L-6) clones. Arch Invest Med (Mex) 21(Suppl 1):175\u2013181","journal-title":"Arch Invest Med (Mex)"},{"issue":"5","key":"852_CR71","doi-asserted-by":"publisher","first-page":"e1000434","DOI":"10.1371\/journal.ppat.1000434","volume":"5","author":"H Lotter","year":"2009","unstructured":"Lotter H, Gonzalez-Roldan N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer AJ, Holst O, Tannich E, Jacobs T (2009) Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess. PLoS Pathog 5(5):e1000434","journal-title":"PLoS Pathog"},{"issue":"4","key":"852_CR72","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/hep.24457","volume":"54","author":"HL Van Sweringen","year":"2011","unstructured":"Van Sweringen HL, Sakai N, Tevar AD, Burns JM, Edwards MJ, Lentsch AB (2011) CXC chemokine signaling in the liver: impact on repair and regeneration. Hepatology 54(4):1445\u20131453","journal-title":"Hepatology"},{"issue":"1","key":"852_CR73","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jhep.2004.11.008","volume":"42","author":"WK Lai","year":"2005","unstructured":"Lai WK, Adams DH (2005) Angiogenesis and chronic inflammation; the potential for novel therapeutic approaches in chronic liver disease. J Hepatol 42(1):7\u201311","journal-title":"J Hepatol"},{"issue":"2","key":"852_CR74","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10456-014-9454-1","volume":"18","author":"MH Vries","year":"2015","unstructured":"Vries MH, Wagenaar A, Verbruggen SE, Molin DG, Dijkgraaf I, Hackeng TH, Post MJ (2015) CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis 18(2):163\u2013171","journal-title":"Angiogenesis"},{"issue":"11","key":"852_CR75","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1128\/IAI.00798-10","volume":"78","author":"AM Ritzman","year":"2010","unstructured":"Ritzman AM, Hughes-Hanks JM, Blaho VA, Wax LE, Mitchell WJ, Brown CR (2010) The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun 78(11):4593\u20134600","journal-title":"Infect Immun"},{"issue":"20","key":"852_CR76","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","volume":"39","author":"L Wang","year":"2018","unstructured":"Wang L, Zhang YL, Lin QY, Liu Y, Guan XM, Ma XL, Cao HJ, Liu Y, Bai J, Xia YL, Du J, Li HH (2018) CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur Heart J 39(20):1818\u20131831","journal-title":"Eur Heart J"},{"issue":"5","key":"852_CR77","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.4049\/jimmunol.1700129","volume":"199","author":"M Boro","year":"2017","unstructured":"Boro M, Balaji KN (2017) CXCL1 and CXCL2 regulate NLRP3 inflammasome activation via G-protein-coupled receptor CXCR2. J Immunol 199(5):1660\u20131671","journal-title":"J Immunol"},{"issue":"3","key":"852_CR78","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1189\/jlb.1206735","volume":"82","author":"KA Gauss","year":"2007","unstructured":"Gauss KA, Nelson-Overton LK, Siemsen DW, Gao Y, DeLeo FR, Quinn MT (2007) Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha. J Leukoc Biol 82(3):729\u2013741","journal-title":"J Leukoc Biol"},{"key":"852_CR79","doi-asserted-by":"crossref","unstructured":"Seguin R, Mann BJ, Keller K, Chadee K (1997) The tumor necrosis factor alpha-stimulating region of galactose-inhibitable lectin of Entamoeba histolytica activates gamma interferon-primed macrophages for amebicidal activity mediated by nitric oxide. Infect Immun 65(7):2522\u20132527","DOI":"10.1128\/iai.65.7.2522-2527.1997"},{"issue":"Pt 3","key":"852_CR80","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1042\/bj3301217","volume":"330","author":"I Bruchhaus","year":"1998","unstructured":"Bruchhaus I, Richter S, Tannich E (1998) Recombinant expression and biochemical characterization of an NADPH:flavin oxidoreductase from Entamoeba histolytica. Biochem J 330(Pt 3):1217\u20131221","journal-title":"Biochem J"},{"issue":"11-12","key":"852_CR81","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.0141-9838.2004.00669.x","volume":"25","author":"K Elnekave","year":"2003","unstructured":"Elnekave K, Siman-Tov R, Ankri S (2003) Consumption of L-arginine mediated by Entamoeba histolytica L-arginase (EhArg) inhibits amoebicidal activity and nitric oxide production by activated macrophages. Parasite Immunol 25(11-12):597\u2013608","journal-title":"Parasite Immunol"},{"issue":"46","key":"852_CR82","doi-asserted-by":"publisher","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","volume":"109","author":"P Ramachandran","year":"2012","unstructured":"Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP (2012) Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A 109(46):E3186\u2013E3195","journal-title":"Proc Natl Acad Sci U S A"},{"key":"852_CR83","doi-asserted-by":"crossref","unstructured":"Dos Santos Meira C, Gedamu L (2019) Protective or detrimental? Understanding the role of host immunity in leishmaniasis. Microorganisms 7(12)","DOI":"10.3390\/microorganisms7120695"},{"key":"852_CR84","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/B978-0-12-407679-2.00005-3","volume":"82","author":"G Gupta","year":"2013","unstructured":"Gupta G, Oghumu S, Satoskar AR (2013) Mechanisms of immune evasion in leishmaniasis. Adv Appl Microbiol 82:155\u2013184","journal-title":"Adv Appl Microbiol"},{"issue":"1","key":"852_CR85","doi-asserted-by":"publisher","first-page":"14693","DOI":"10.1038\/s41598-017-14935-3","volume":"7","author":"C Terrazas","year":"2017","unstructured":"Terrazas C, Varikuti S, Oghumu S, Steinkamp HM, Ardic N, Kimble J, Nakhasi H, Satoskar AR (2017) Ly6C(hi) inflammatory monocytes promote susceptibility to Leishmania donovani infection. Sci Rep 7(1):14693","journal-title":"Sci Rep"},{"key":"852_CR86","first-page":"83","volume":"2","author":"D Liu","year":"2012","unstructured":"Liu D, Uzonna JE (2012) The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response. Front Cell Infect Microbiol 2:83","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"852_CR87","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4049\/jimmunol.177.1.22","volume":"177","author":"LE Rosas","year":"2006","unstructured":"Rosas LE, Snider HM, Barbi J, Satoskar AA, Lugo-Villarino G, Keiser T, Papenfuss T, Durbin JE, Radzioch D, Glimcher LH, Satoskar AR (2006) Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22\u201325","journal-title":"J Immunol"},{"issue":"12","key":"852_CR88","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.4049\/jimmunol.1501046","volume":"195","author":"M Sheel","year":"2015","unstructured":"Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR (2015) IL-17A-producing gammadelta T cells suppress early control of parasite growth by monocytes in the liver. J Immunol 195(12):5707\u20135717","journal-title":"J Immunol"},{"issue":"2","key":"852_CR89","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/infdis\/jiu439","volume":"211","author":"S Passos","year":"2015","unstructured":"Passos S, Carvalho LP, Costa RS, Campos TM, Novais FO, Magalhaes A, Machado PR, Beiting D, Mosser D, Carvalho EM, Scott P (2015) Intermediate monocytes contribute to pathologic immune response in Leishmania braziliensis infections. J Infect Dis 211(2):274\u2013282","journal-title":"J Infect Dis"},{"issue":"5","key":"852_CR90","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.jid.2017.11.029","volume":"138","author":"D Santos","year":"2018","unstructured":"Santos D, Campos TM, Saldanha M, Oliveira SC, Nascimento M, Zamboni DS, Machado PR, Arruda S, Scott P, Carvalho EM, Carvalho LP (2018) IL-1beta production by intermediate monocytes is associated with immunopathology in cutaneous leishmaniasis. J Invest Dermatol 138(5):1107\u20131115","journal-title":"J Invest Dermatol"},{"key":"852_CR91","doi-asserted-by":"publisher","first-page":"4103819","DOI":"10.1155\/2019\/4103819","volume":"2019","author":"RD Lockard","year":"2019","unstructured":"Lockard RD, Wilson ME, Rodriguez NE (2019) Sex-related differences in immune response and symptomatic manifestations to infection with Leishmania species. J Immunol Res 2019:4103819","journal-title":"J Immunol Res"},{"issue":"9-10","key":"852_CR92","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.imbio.2009.06.010","volume":"214","author":"T Bosschaerts","year":"2009","unstructured":"Bosschaerts T, Guilliams M, Stijlemans B, De Baetselier P, Beschin A (2009) Understanding the role of monocytic cells in liver inflammation using parasite infection as a model. Immunobiology 214(9-10):737\u2013747","journal-title":"Immunobiology"},{"issue":"9","key":"852_CR93","doi-asserted-by":"publisher","first-page":"e1004414","DOI":"10.1371\/journal.ppat.1004414","volume":"10","author":"B Stijlemans","year":"2014","unstructured":"Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P (2014) MIF contributes to Trypanosoma brucei associated immunopathogenicity development. PLoS Pathog 10(9):e1004414","journal-title":"PLoS Pathog"},{"issue":"2","key":"852_CR94","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.4049\/jimmunol.182.2.1107","volume":"182","author":"M Guilliams","year":"2009","unstructured":"Guilliams M, Movahedi K, Bosschaerts T, VandenDriessche T, Chuah MK, H\u00e9rin M, Acosta-Sanchez A, Ma L, Moser M, Van Ginderachter JA, Brys L, De Baetselier P, Beschin A (2009) IL-10 dampens TNF\/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection. J Immunol 182(2):1107\u20131118","journal-title":"J Immunol"},{"issue":"9936","key":"852_CR95","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","volume":"383","author":"DG Colley","year":"2014","unstructured":"Colley DG, Bustinduy AL, Secor WE, King CH (2014) Human schistosomiasis. Lancet 383(9936):2253\u20132264","journal-title":"Lancet"},{"key":"852_CR96","first-page":"703653","volume":"2014","author":"JS Fernandes","year":"2014","unstructured":"Fernandes JS, Araujo MI, Lopes DM, de Souza Rda P, Carvalho EM, Cardoso LS (2014) Monocyte subsets in schistosomiasis patients with periportal fibrosis. Mediat Inflamm 2014:703653","journal-title":"Mediat Inflamm"},{"issue":"8","key":"852_CR97","doi-asserted-by":"publisher","first-page":"e1004282","DOI":"10.1371\/journal.ppat.1004282","volume":"10","author":"M Nascimento","year":"2014","unstructured":"Nascimento M, Huang SC, Smith A, Everts B, Lam W, Bassity E, Gautier EL, Randolph GJ, Pearce EJ (2014) Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis. PLoS Pathog 10(8):e1004282","journal-title":"PLoS Pathog"},{"key":"852_CR98","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3389\/fmicb.2020.01973","volume":"11","author":"COS Souza","year":"2020","unstructured":"Souza COS, Gardinassi LG, Rodrigues V, Faccioli LH (2020) Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis. Front Microbiol 11:1973","journal-title":"Front Microbiol"},{"key":"852_CR99","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.3389\/fimmu.2018.01970","volume":"9","author":"COS Souza","year":"2018","unstructured":"Souza COS, Esp\u00edndola MS, Fontanari C, Prado MKB, Frantz FG, Rodrigues V, Gardinassi LG, Faccioli LH (2018) CD18 Regulates monocyte hematopoiesis and promotes resistance to experimental schistosomiasis. Front Immunol 9:1970","journal-title":"Front Immunol"},{"issue":"1","key":"852_CR100","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1038\/s41598-019-42703-y","volume":"9","author":"VCA de Souza","year":"2019","unstructured":"de Souza VCA, Moura DMN, de Castro M, Bozza PT, de Almeida Paiva L, Fernandes CJB, Leao RLC, Lucena JP, de Araujo RE, de Melo Silva AJ, Figueiredo R, de Oliveira SA (2019) Adoptive transfer of bone marrow-derived monocytes ameliorates schistosoma mansoni -induced liver fibrosis in mice. Sci Rep 9(1):6434","journal-title":"Sci Rep"},{"issue":"3","key":"852_CR101","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1006\/expr.1997.4148","volume":"85","author":"M Nakazawa","year":"1997","unstructured":"Nakazawa M, Fantappie MR, Freeman GL Jr, Eloi-Santos S, Olsen NJ, Kovacs WJ, Secor WE, Colley DG (1997) Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection. Exp Parasitol 85(3):233\u2013240","journal-title":"Exp Parasitol"},{"issue":"3","key":"852_CR102","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/pim.12282","volume":"38","author":"A D\u00edaz","year":"2016","unstructured":"D\u00edaz A, Casaravilla C, Barrios AA, Ferreira AM (2016) Parasite molecules and host responses in cystic echinococcosis. Parasite Immunol 38(3):193\u2013205","journal-title":"Parasite Immunol"},{"key":"852_CR103","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13071-016-1350-7","volume":"9","author":"V Silva-\u00c1lvarez","year":"2016","unstructured":"Silva-\u00c1lvarez V, Folle AM, Ramos AL, Kitano ES, Iwai LK, Corraliza I, C\u00f3rsico B, Ferreira AM (2016) Echinococcus granulosus antigen B binds to monocytes and macrophages modulating cell response to inflammation. Parasit Vectors 9:69","journal-title":"Parasit Vectors"},{"issue":"3","key":"852_CR104","first-page":"201","volume":"30","author":"HQ Yang","year":"2012","unstructured":"Yang HQ, Ma SB, Bian ZY, Li J, Zou H, Zhang SJ, Peng XY, Chen XP (2012) Expression of tumor necrosis factor-alpha and caspase-3 protein in monocytes adjacent to the invaded Echinococcus multilocularis in liver. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 30(3):201\u2013205","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"issue":"4","key":"852_CR105","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1128\/IAI.00472-09","volume":"78","author":"IR Dunay","year":"2010","unstructured":"Dunay IR, Fuchs A, Sibley LD (2010) Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice. Infect Immun 78(4):1564\u20131570","journal-title":"Infect Immun"},{"issue":"6","key":"852_CR106","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm.3189","volume":"19","author":"JR Grainger","year":"2013","unstructured":"Grainger JR, Wohlfert EA, Fuss IJ, Bouladoux N, Askenase MH, Legrand F, Koo LY, Brenchley JM, Fraser ID, Belkaid Y (2013) Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nat Med 19(6):713\u2013721","journal-title":"Nat Med"},{"issue":"6","key":"852_CR107","doi-asserted-by":"publisher","first-page":"e1004203","DOI":"10.1371\/journal.ppat.1004203","volume":"10","author":"LM Neal","year":"2014","unstructured":"Neal LM, Knoll LJ (2014) Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection. PLoS Pathog 10(6):e1004203","journal-title":"PLoS Pathog"},{"issue":"13","key":"852_CR108","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1084\/jem.20090900","volume":"206","author":"M Mu\u00f1oz","year":"2009","unstructured":"Mu\u00f1oz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, H\u00f6lscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O (2009) Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med 206(13):3047\u20133059","journal-title":"J Exp Med"},{"issue":"7","key":"852_CR109","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1084\/jem.20160334","volume":"213","author":"BG Surewaard","year":"2016","unstructured":"Surewaard BG, Deniset JF, Zemp FJ, Amrein M, Otto M, Conly J, Omri A, Yates RM, Kubes P (2016) Identification and treatment of the Staphylococcus aureus reservoir in vivo. J Exp Med 213(7):1141\u20131151","journal-title":"J Exp Med"},{"issue":"11","key":"852_CR110","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1172\/JCI127286","volume":"129","author":"SK Jorch","year":"2019","unstructured":"Jorch SK, Surewaard BG, Hossain M, Peiseler M, Deppermann C, Deng J, Bogoslowski A, van der Wal F, Omri A, Hickey MJ, Kubes P (2019) Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. J Clin Invest 129(11):4643\u20134656","journal-title":"J Clin Invest"},{"key":"852_CR111","doi-asserted-by":"crossref","unstructured":"Wang G, Zhao H, Zheng B, Li D, Yuan Y, Han Q, Tian Z, Zhang J (2019) TLR2 promotes monocyte\/macrophage recruitment into the liver and microabscess formation to limit the spread of listeria monocytogenes. Front Immunol 10(1388)","DOI":"10.3389\/fimmu.2019.01388"},{"issue":"7","key":"852_CR112","doi-asserted-by":"publisher","first-page":"e1007847","DOI":"10.1371\/journal.ppat.1007847","volume":"15","author":"PA McLaughlin","year":"2019","unstructured":"McLaughlin PA, Bettke JA, Tam JW, Leeds J, Bliska JB, Butler BP, van der Velden AWM (2019) Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine. PLoS Pathog 15(7):e1007847","journal-title":"PLoS Pathog"},{"key":"852_CR113","doi-asserted-by":"crossref","unstructured":"Zhang Y, Khairallah C, Sheridan BS, van der Velden AWM, Bliska JB (2018) CCR2(+) Inflammatory monocytes are recruited to Yersinia pseudotuberculosis pyogranulomas and dictate adaptive responses at the expense of innate immunity during oral infection. Infect Immun 86(3)","DOI":"10.1128\/IAI.00782-17"},{"issue":"22","key":"852_CR114","doi-asserted-by":"publisher","first-page":"12647","DOI":"10.1128\/JVI.78.22.12647-12656.2004","volume":"78","author":"C Thepparit","year":"2004","unstructured":"Thepparit C, Smith DR (2004) Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton\/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor. J Virol 78(22):12647\u201312656","journal-title":"J Virol"},{"issue":"2","key":"852_CR115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s004280000329","volume":"438","author":"MR Huerre","year":"2001","unstructured":"Huerre MR, Lan NT, Marianneau P, Hue NB, Khun H, Hung NT, Khen NT, Drouet MT, Huong VT, Ha DQ, Buisson Y, Deubel V (2001) Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 438(2):107\u2013115","journal-title":"Virchows Arch"},{"issue":"1","key":"852_CR116","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1038\/s41467-020-16849-7","volume":"11","author":"JA Aguilar-Brise\u00f1o","year":"2020","unstructured":"Aguilar-Brise\u00f1o JA, Upasani V, Ellen BMT, Moser J, Pauzuolis M, Ruiz-Silva M, Heng S, Laurent D, Choeung R, Dussart P, Cantaert T, Smit JM, Rodenhuis-Zybert IA (2020) TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis. Nat Commun 11(1):3177","journal-title":"Nat Commun"},{"issue":"2","key":"852_CR117","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/imm.13011","volume":"156","author":"JS Naranjo-G\u00f3mez","year":"2019","unstructured":"Naranjo-G\u00f3mez JS, Castillo JA, Rojas M, Restrepo BN, Diaz FJ, Velilla PA, Casta\u00f1o D (2019) Different phenotypes of non-classical monocytes associated with systemic inflammation, endothelial alteration and hepatic compromise in patients with dengue. Immunology 156(2):147\u2013163","journal-title":"Immunology"},{"issue":"11","key":"852_CR118","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1056\/NEJMra031087","volume":"350","author":"D Ganem","year":"2004","unstructured":"Ganem D, Prince AM (2004) Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med 350(11):1118\u20131129","journal-title":"N Engl J Med"},{"issue":"10","key":"852_CR119","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1084\/jem.194.10.1395","volume":"194","author":"R Thimme","year":"2001","unstructured":"Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV (2001) Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194(10):1395\u20131406","journal-title":"J Exp Med"},{"issue":"8","key":"852_CR120","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nri.2016.69","volume":"16","author":"EC Shin","year":"2016","unstructured":"Shin EC, Sung PS, Park SH (2016) Immune responses and immunopathology in acute and chronic viral hepatitis. Nat Rev Immunol 16(8):509\u2013523","journal-title":"Nat Rev Immunol"},{"issue":"1 Suppl","key":"852_CR121","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.jhep.2016.01.026","volume":"64","author":"A Bertoletti","year":"2016","unstructured":"Bertoletti A, Ferrari C (2016) Adaptive immunity in HBV infection. J Hepatol 64(1 Suppl):S71\u2013s83","journal-title":"J Hepatol"},{"issue":"8","key":"852_CR122","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.4049\/jimmunol.1800848","volume":"202","author":"H Song","year":"2019","unstructured":"Song H, Tan G, Yang Y, Cui A, Li H, Li T, Wu Z, Yang M, Lv G, Chi X, Niu J, Zhu K, Crispe IN, Su L, Tu Z (2019) Hepatitis B virus\u2013induced imbalance of inflammatory and antiviral signaling by differential phosphorylation of STAT1 in human monocytes. J Immunol 202(8):2266\u20132275","journal-title":"J Immunol"},{"issue":"1 Suppl","key":"852_CR123","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.jhep.2016.01.028","volume":"64","author":"MK Maini","year":"2016","unstructured":"Maini MK, Gehring AJ (2016) The role of innate immunity in the immunopathology and treatment of HBV infection. J Hepatol 64(1 Suppl):S60\u2013s70","journal-title":"J Hepatol"},{"issue":"5","key":"852_CR124","doi-asserted-by":"publisher","first-page":"e97006","DOI":"10.1371\/journal.pone.0097006","volume":"9","author":"A Boltjes","year":"2014","unstructured":"Boltjes A, Groothuismink ZM, van Oord GW, Janssen HL, Woltman AM, Boonstra A (2014) Monocytes from chronic HBV patients react in vitro to HBsAg and TLR by producing cytokines irrespective of stage of disease. PLoS One 9(5):e97006","journal-title":"PLoS One"},{"issue":"3","key":"852_CR125","doi-asserted-by":"publisher","first-page":"e17484","DOI":"10.1371\/journal.pone.0017484","volume":"6","author":"JY Zhang","year":"2011","unstructured":"Zhang JY, Zou ZS, Huang A, Zhang Z, Fu JL, Xu XS, Chen LM, Li BS, Wang FS (2011) Hyper-activated pro-inflammatory CD16 monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis B. PLoS One 6(3):e17484","journal-title":"PLoS One"},{"issue":"8","key":"852_CR126","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/infdis\/jiu599","volume":"211","author":"A Boltjes","year":"2015","unstructured":"Boltjes A, van Montfoort N, Biesta PJ, Op den Brouw ML, Kwekkeboom J, van der Laan LJ, Janssen HL, Boonstra A, Woltman AM (2015) Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function. J Infect Dis 211(8):1268\u20131278","journal-title":"J Infect Dis"},{"issue":"3","key":"852_CR127","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.jhep.2017.04.023","volume":"67","author":"A Tan-Garcia","year":"2017","unstructured":"Tan-Garcia A, Wai LE, Zheng D, Ceccarello E, Jo J, Banu N, Khakpoor A, Chia A, Tham CYL, Tan AT, Hong M, Keng CT, Rivino L, Tan KC, Lee KH, Lim SG, Newell EW, Pavelka N, Chen J, Ginhoux F, Chen Q, Bertoletti A, Dutertre CA (2017) Intrahepatic CD206(+) macrophages contribute to inflammation in advanced viral-related liver disease. J Hepatol 67(3):490\u2013500","journal-title":"J Hepatol"},{"issue":"1","key":"852_CR128","doi-asserted-by":"publisher","first-page":"100062","DOI":"10.1016\/j.jhepr.2019.11.006","volume":"2","author":"A Tan-Garcia","year":"2020","unstructured":"Tan-Garcia A, Lai F, Sheng Yeong JP, Irac SE, Ng PY, Msallam R, Tatt Lim JC, Wai LE, Tham CYL, Choo SP, Lim T, Young DY, D'Ambrosio R, Degasperi E, Perbellini R, Newell E, Le Bert N, Ginhoux F, Bertoletti A, Chen Q, Dutertre CA (2020) Liver fibrosis and CD206(+) macrophage accumulation are suppressed by anti-GM-CSF therapy. JHEP Rep 2(1):100062","journal-title":"JHEP Rep"},{"issue":"10","key":"852_CR129","doi-asserted-by":"publisher","first-page":"5142","DOI":"10.4049\/jimmunol.1201625","volume":"190","author":"S Wang","year":"2013","unstructured":"Wang S, Chen Z, Hu C, Qian F, Cheng Y, Wu M, Shi B, Chen J, Hu Y, Yuan Z (2013) Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes\/macrophages by interfering with JNK activation. J Immunol 190(10):5142\u20135151","journal-title":"J Immunol"},{"issue":"4","key":"852_CR130","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1046\/j.1365-2567.2003.01699.x","volume":"109","author":"S Beckebaum","year":"2003","unstructured":"Beckebaum S, Cicinnati VR, Zhang X, Ferencik S, Frilling A, Grosse-Wilde H, Broelsch CE, Gerken G (2003) Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape. Immunology 109(4):487\u2013495","journal-title":"Immunology"},{"issue":"1","key":"852_CR131","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/hep.21482","volume":"45","author":"K Visvanathan","year":"2007","unstructured":"Visvanathan K, Skinner NA, Thompson AJ, Riordan SM, Sozzi V, Edwards R, Rodgers S, Kurtovic J, Chang J, Lewin S, Desmond P, Locarnini S (2007) Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 45(1):102\u2013110","journal-title":"Hepatology"},{"issue":"3","key":"852_CR132","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jcmgh.2015.12.005","volume":"2","author":"B Saha","year":"2016","unstructured":"Saha B, Kodys K, Szabo G (2016) Hepatitis C virus-induced monocyte differentiation into polarized m2 macrophages promotes stellate cell activation via TGF-\u03b2. Cell Mol Gastroenterol Hepatol 2(3):302\u2013316.e8","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"852_CR133","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/gut.46.2.260","volume":"46","author":"PH McGuinness","year":"2000","unstructured":"McGuinness PH, Painter D, Davies S, McCaughan GW (2000) Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 46(2):260\u2013269","journal-title":"Gut"},{"issue":"1","key":"852_CR134","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1053\/j.gastro.2009.09.009","volume":"138","author":"Z Tu","year":"2010","unstructured":"Tu Z, Pierce RH, Kurtis J, Kuroki Y, Crispe IN, Orloff MS (2010) Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 138(1):305\u2013314","journal-title":"Gastroenterology"},{"issue":"5","key":"852_CR135","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.4049\/jimmunol.1002006","volume":"186","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Ma CJ, Ni L, Zhang CL, Wu XY, Kumaraguru U, Li CF, Moorman JP, Yao ZQ (2011) Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of il-12 production by monocytes\/macrophages in hepatitis c virus infection. J Immunol 186(5):3093\u20133103","journal-title":"J Immunol"},{"issue":"6","key":"852_CR136","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","volume":"66","author":"F Tacke","year":"2017","unstructured":"Tacke F (2017) Targeting hepatic macrophages to treat liver diseases. J Hepatol 66(6):1300\u20131312","journal-title":"J Hepatol"},{"issue":"11","key":"852_CR137","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.3390\/v4112650","volume":"4","author":"X Zhou","year":"2012","unstructured":"Zhou X, Ramachandran S, Mann M, Popkin DL (2012) Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future. Viruses 4(11):2650\u20132669","journal-title":"Viruses"},{"issue":"9","key":"852_CR138","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1128\/JVI.03733-14","volume":"89","author":"D Movita","year":"2015","unstructured":"Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T (2015) Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol 89(9):4809\u20134817","journal-title":"J Virol"},{"key":"852_CR139","doi-asserted-by":"crossref","unstructured":"Sammicheli S, Kuka M, Di Lucia P, de Oya NJ, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M (2016) Inflammatory monocytes hinder antiviral B cell responses. Sci Immunol 1(4)","DOI":"10.1126\/sciimmunol.aah6789"},{"issue":"1 Supplement","key":"852_CR140","doi-asserted-by":"crossref","first-page":"78.39","DOI":"10.4049\/jimmunol.198.Supp.78.39","volume":"198","author":"K-S Shin","year":"2017","unstructured":"Shin K-S, Park Y-J, Koh C-H, Bae E-A, Kim I-K, Song B, Seo H, Jeon I, Kang C-Y (2017) IFN-\u03b3-induced MHCII+ inflammatory monocytes play a role for down-regulating CD8 T cell responses in acute LCMV infection. J Immunol 198(1 Supplement):78.39","journal-title":"J Immunol"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00852-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-021-00852-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00852-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T20:03:40Z","timestamp":1698869020000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-021-00852-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":140,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["852"],"URL":"https:\/\/doi.org\/10.1007\/s00281-021-00852-1","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]},"assertion":[{"value":"28 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}