{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:22:28Z","timestamp":1793110948586,"version":"4.5.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Bari Aldo Moro"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:title>\n                  <jats:p>The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.<\/jats:p>","DOI":"10.1007\/s00281-021-00871-y","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T23:55:50Z","timestamp":1634082950000},"page":"657-668","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["The mucosal immune system and IgA nephropathy"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-0911","authenticated-orcid":false,"given":"Loreto","family":"Gesualdo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Coppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"issue":"3","key":"871_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/81677","volume":"26","author":"AG Gharavi","year":"2000","unstructured":"Gharavi AG, Yan Y, Scolari F, Schena FP, Frasca GM, Ghiggeri GM, Cooper K, Amoroso A, Viola BF, Battini G, Caridi G, Canova C, Farhi A, Subramanian V, Nelson-Williams C, Woodford S, Julian BA, Wyatt RJ, Lifton RP (2000) IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet 26(3):354\u2013357","journal-title":"Nat Genet"},{"issue":"4","key":"871_CR2","first-page":"939","volume":"1","author":"J Berger","year":"1969","unstructured":"Berger J (1969) IgA glomerular deposits in renal disease. Transplant Proc 1(4):939\u2013944","journal-title":"Transplant Proc"},{"issue":"5","key":"871_CR3","first-page":"583","volume":"7","author":"M Miura","year":"1982","unstructured":"Miura M, Tomino Y, Endoh M, Suga T, Kaneshige H, Nomoto Y, Sakai H (1982) A case of IgA nephropathy associated with marked hematuria after upper respiratory tract infections. Tokai J Exp Clin Med 7(5):583\u2013587","journal-title":"Tokai J Exp Clin Med"},{"issue":"5","key":"871_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s00108-019-0588-5","volume":"60","author":"C Seikrit","year":"2019","unstructured":"Seikrit C, Rauen T, Floege J (2019) Immunoglobulin A nephropathy. Internist (Berl) 60(5):432\u2013439","journal-title":"Internist (Berl)"},{"issue":"Suppl 1","key":"871_CR5","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.nephro.2018.02.004","volume":"14","author":"RC Monteiro","year":"2018","unstructured":"Monteiro RC (2018) Recent advances in the physiopathology of IgA nephropathy. Nephrol Ther 14(Suppl 1):S1\u2013S8","journal-title":"Nephrol Ther"},{"issue":"1","key":"871_CR6","doi-asserted-by":"publisher","first-page":"e0190967","DOI":"10.1371\/journal.pone.0190967","volume":"13","author":"WJ Placzek","year":"2018","unstructured":"Placzek WJ, Yanagawa H, Makita Y, Renfrow MB, Julian BA, Rizk DV, Suzuki Y, Novak J, Suzuki H (2018) Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy. PLoS One 13(1):e0190967","journal-title":"PLoS One"},{"issue":"10","key":"871_CR7","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1681\/ASN.2011050464","volume":"22","author":"H Suzuki","year":"2011","unstructured":"Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, Wyatt RJ, Scolari F, Mestecky J, Gharavi AG, Julian BA (2011) The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22(10):1795\u20131803","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"871_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s10157-018-1582-2","volume":"23","author":"H Suzuki","year":"2019","unstructured":"Suzuki H (2019) Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis. Clin Exp Nephrol 23(1):26\u201331","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"871_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2249.2006.03026.x","volume":"144","author":"Y Yan","year":"2006","unstructured":"Yan Y, Xu LX, Zhang JJ, Zhang Y, Zhao MH (2006) Self-aggregated deglycosylated IgA1 with or without IgG were associated with the development of IgA nephropathy. Clin Exp Immunol 144(1):17\u201324","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"871_CR10","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/ndt\/gfu343","volume":"30","author":"R Coppo","year":"2015","unstructured":"Coppo R (2015) The intestine-renal connection in IgA nephropathy. Nephrol Dial Transplant 30(3):360\u2013366","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"871_CR11","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00467-016-3575-2","volume":"32","author":"R Coppo","year":"2017","unstructured":"Coppo R (2017) C4d deposits in IgA nephropathy: where does complement activation come from? Pediatr Nephrol 32(7):1097\u20131101","journal-title":"Pediatr Nephrol"},{"issue":"7","key":"871_CR12","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1681\/ASN.2014101000","volume":"26","author":"N Maillard","year":"2015","unstructured":"Maillard N, Wyatt RJ, Julian BA, Kiryluk K, Gharavi A, Fremeaux-Bacchi V, Novak J (2015) Current understanding of the role of complement in IgA nephropathy. J Am Soc Nephrol 26(7):1503\u20131512","journal-title":"J Am Soc Nephrol"},{"key":"871_CR13","doi-asserted-by":"crossref","unstructured":"Bienenstock, KCAJ (1994) Characteristics and functions of mucosa-associated lymphoid tissue. Handbook of mucosal immunology 141-149","DOI":"10.1016\/B978-0-12-524730-6.50017-8"},{"issue":"2","key":"871_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1023\/A:1006191022900","volume":"22","author":"PD Gormley","year":"1998","unstructured":"Gormley PD, Powell-Richards AOR, Azuara-Blanco A, Donoso LA, Dua HS (1998) Lymphocyte subsets in conjunctival mucosa-associated-lymphoid-tissue after exposure to retinal-S-antigen. Int Ophthalmol 22(2):77\u201380","journal-title":"Int Ophthalmol"},{"issue":"9","key":"871_CR15","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/nri1439","volume":"4","author":"H Kiyono","year":"2004","unstructured":"Kiyono H, Fukuyama S (2004) NALT- versus Peyer\u2019s-patch-mediated mucosal immunity. Nat Rev Immunol 4(9):699\u2013710","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"871_CR16","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/mi.2014.11","volume":"7","author":"TD Randall","year":"2014","unstructured":"Randall TD, Mebius RE (2014) The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms. Mucosal Immunol 7(3):455\u2013466","journal-title":"Mucosal Immunol"},{"issue":"1","key":"871_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12565-017-0418-6","volume":"93","author":"S Kimura","year":"2018","unstructured":"Kimura S (2018) Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues. Anat Sci Int 93(1):23\u201334","journal-title":"Anat Sci Int"},{"issue":"5","key":"871_CR18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1080\/01926230600865531","volume":"34","author":"MF Cesta","year":"2006","unstructured":"Cesta MF (2006) Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol 34(5):599\u2013608","journal-title":"Toxicol Pathol"},{"issue":"2","key":"871_CR19","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/iid3.248","volume":"7","author":"Y Harabuchi","year":"2019","unstructured":"Harabuchi Y, Takahara M (2019) Recent advances in the immunological understanding of association between tonsil and immunoglobulin A nephropathy as a tonsil-induced autoimmune\/inflammatory syndrome. Immun Inflamm Dis 7(2):86\u201393","journal-title":"Immun Inflamm Dis"},{"key":"871_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-immunol-030409-101314","volume":"28","author":"S Fagarasan","year":"2010","unstructured":"Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K (2010) Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol 28:243\u2013273","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"871_CR21","doi-asserted-by":"publisher","first-page":"683","DOI":"10.5301\/jn.5000218","volume":"26","author":"G Xin","year":"2013","unstructured":"Xin G, Shi W, Xu LX, Su Y, Yan LJ, Li KS (2013) Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features. J Nephrol 26(4):683\u2013690","journal-title":"J Nephrol"},{"issue":"1","key":"871_CR22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12189","volume":"260","author":"C Gutzeit","year":"2014","unstructured":"Gutzeit C, Magri G, Cerutti A (2014) Intestinal IgA production and its role in host-microbe interaction. Immunol Rev 260(1):76\u201385","journal-title":"Immunol Rev"},{"issue":"4","key":"871_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s40620-016-0265-x","volume":"29","author":"C Rollino","year":"2016","unstructured":"Rollino C, Vischini G, Coppo R (2016) IgA nephropathy and infections. J Nephrol 29(4):463\u2013468","journal-title":"J Nephrol"},{"key":"871_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fimmu.2016.00117","volume":"7","author":"B Knoppova","year":"2016","unstructured":"Knoppova B et al (2016) The origin and activities of IgA1-containing immune complexes in IgA nephropathy. Front Immunol 7:117","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"871_CR25","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1016\/j.nephro.2018.02.010","volume":"14","author":"R Coppo","year":"2018","unstructured":"Coppo R (2018) Treatment of IgA nephropathy: recent advances and prospects. Nephrol Ther 14(Suppl 1):S13\u2013S21","journal-title":"Nephrol Ther"},{"issue":"2","key":"871_CR26","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s12016-010-8232-0","volume":"41","author":"HH Yu","year":"2011","unstructured":"Yu HH, Chu KH, Yang YH, Lee JH, Wang LC, Lin YT, Chiang BL (2011) Genetics and immunopathogenesis of IgA nephropathy. Clin Rev Allergy Immunol 41(2):198\u2013213","journal-title":"Clin Rev Allergy Immunol"},{"issue":"2","key":"871_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.5527\/wjn.v4.i2.185","volume":"4","author":"C Yuste","year":"2015","unstructured":"Yuste C, Gutierrez E, Sevillano AM, Rubio-Navarro A, Amaro-Villalobos JM, Ortiz A, Egido J, Praga M, Moreno JA (2015) Pathogenesis of glomerular haematuria. World J Nephrol 4(2):185\u2013195","journal-title":"World J Nephrol"},{"issue":"6","key":"871_CR28","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/ki.1986.274","volume":"30","author":"J Feehally","year":"1986","unstructured":"Feehally J, Beattie TJ, Brenchley PEC, Coupes BM, Mallick NP, Postlethwaite RJ (1986) Sequential study of the IgA system in relapsing IgA nephropathy. Kidney Int 30(6):924\u2013931","journal-title":"Kidney Int"},{"issue":"3","key":"871_CR29","first-page":"605","volume":"51","author":"Y Tomino","year":"1983","unstructured":"Tomino Y, Sakai H, Endoh M, Suga T, Miura M, Kaneshige H, Nomoto Y (1983) Cross-reactivity of IgA antibodies between renal mesangial areas and nuclei of tonsillar cells in patients with IgA nephropathy. Clin Exp Immunol 51(3):605\u2013610","journal-title":"Clin Exp Immunol"},{"key":"871_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000422408","volume":"104","author":"MC Bene","year":"1993","unstructured":"Bene MC et al (1993) Tonsils in IgA nephropathy. Contrib Nephrol 104:153\u2013161","journal-title":"Contrib Nephrol"},{"issue":"6","key":"871_CR31","first-page":"626","volume":"23","author":"R Coppo","year":"2010","unstructured":"Coppo R, Amore A, Peruzzi L, Vergano L, Camilla R (2010) Innate immunity and IgA nephropathy. J Nephrol 23(6):626\u2013632","journal-title":"J Nephrol"},{"issue":"1","key":"871_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.clim.2004.06.002","volume":"113","author":"A Amore","year":"2004","unstructured":"Amore A, Coppo R, Nedrud JG, Sigmund N, Lamm ME, Emancipator SN (2004) The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus. Clin Immunol 113(1):101\u2013108","journal-title":"Clin Immunol"},{"issue":"11","key":"871_CR33","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.4049\/jimmunol.145.11.3684","volume":"145","author":"L Gesualdo","year":"1990","unstructured":"Gesualdo L, Lamm ME, Emancipator SN (1990) Defective oral tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization. J Immunol 145(11):3684\u20133691","journal-title":"J Immunol"},{"issue":"1","key":"871_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1053\/ajkd.2000.8264","volume":"36","author":"Y Ogura","year":"2000","unstructured":"Ogura Y, Suzuki S, Shirakawa T, Masuda M, Nakamura H, Iijima K, Yoshikawa N (2000) Haemophilus parainfluenzae antigen and antibody in children with IgA nephropathy and Henoch-Schonlein nephritis. Am J Kidney Dis 36(1):47\u201352","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"871_CR35","first-page":"2072","volume":"32","author":"H Watanabe","year":"2017","unstructured":"Watanabe H et al (2017) Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy. Nephrol Dial Transplant 32(12):2072\u20132079","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"871_CR36","doi-asserted-by":"publisher","first-page":"16206","DOI":"10.1038\/s41598-020-73035-x","volume":"10","author":"JI Park","year":"2020","unstructured":"Park JI, Kim TY, Oh B, Cho H, Kim JE, Yoo SH, Lee JP, Kim YS, Chun J, Kim BS, Lee H (2020) Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases. Sci Rep 10(1):16206","journal-title":"Sci Rep"},{"issue":"4","key":"871_CR37","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1681\/ASN.2016050496","volume":"28","author":"M Muto","year":"2017","unstructured":"Muto M, Manfroi B, Suzuki H, Joh K, Nagai M, Wakai S, Righini C, Maiguma M, Izui S, Tomino Y, Huard B, Suzuki Y (2017) Toll-like receptor 9 stimulation induces aberrant expression of a proliferation-inducing ligand by tonsillar germinal center B cells in IgA nephropathy. J Am Soc Nephrol 28(4):1227\u20131238","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"871_CR38","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s40620-014-0086-8","volume":"28","author":"L Vergano","year":"2015","unstructured":"Vergano L, Loiacono E, Albera R, Coppo R, Camilla R, Peruzzi L, Amore A, Donadio ME, Chiale F, Boido A, Mariano F, Mazzucco G, Ravera S, Cancarini G, Magistroni R, Beltrame G, Rollino C, Stratta P, Quaglia M, Bergia R, Cravero R, Cusinato S, Benozzi L, Savoldi S, Licata C (2015) Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy? J Nephrol 28(1):51\u201358","journal-title":"J Nephrol"},{"key":"871_CR39","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fimmu.2020.00267","volume":"11","author":"K Zachova","year":"2020","unstructured":"Zachova K, Kosztyu P, Zadrazil J, Matousovic K, Vondrak K, Hubacek P, Julian BA, Moldoveanu Z, Novak Z, Kostovcikova K, Raska M, Mestecky J (2020) Role of Epstein-Barr Virus in pathogenesis and racial distribution of IgA nephropathy. Front Immunol 11:267","journal-title":"Front Immunol"},{"issue":"5","key":"871_CR40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1136\/jmedgenet-2016-104304","volume":"54","author":"B Feenstra","year":"2017","unstructured":"Feenstra B, Bager P, Liu X, Hjalgrim H, Nohr EA, Hougaard DM, Geller F, Melbye M (2017) Genome-wide association study identifies variants in HORMAD2 associated with tonsillectomy. J Med Genet 54(5):358\u2013364","journal-title":"J Med Genet"},{"issue":"3","key":"871_CR41","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1159\/000233108","volume":"68","author":"R D'Amelio","year":"1982","unstructured":"D'Amelio R et al (1982) Serum and salivary IgA levels in normal subjects: comparison between tonsillectomized and non-tonsillectomized subjects. Int Arch Allergy Appl Immunol 68(3):256\u2013259","journal-title":"Int Arch Allergy Appl Immunol"},{"issue":"5","key":"871_CR42","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1046\/j.1523-1755.2003.00935.x","volume":"63","author":"Y Xie","year":"2003","unstructured":"Xie Y, Nishi S, Ueno M, Imai N, Sakatsume M, Narita I, Suzuki Y, Akazawa K, Shimada H, Arakawa M, Gejyo F (2003) The efficacy of tonsillectomy on long-term renal survival in patients with IgA nephropathy. Kidney Int 63(5):1861\u20131867","journal-title":"Kidney Int"},{"issue":"8","key":"871_CR43","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1093\/ndt\/gfu068","volume":"29","author":"L Zand","year":"2014","unstructured":"Zand L, Fervenza FC (2014) Does tonsillectomy have a role in the treatment of patients with immunoglobulin A nephropathy? Nephrol Dial Transplant 29(8):1456\u20131459","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"871_CR44","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/ki.2014.63","volume":"86","author":"R Coppo","year":"2014","unstructured":"Coppo R, Troyanov S, Bellur S, Cattran D, Cook HT, Feehally J, Roberts ISD, Morando L, Camilla R, Tesar V, Lunberg S, Gesualdo L, Emma F, Rollino C, Amore A, Praga M, Feriozzi S, Segoloni G, Pani A, Cancarini G, Durlik M, Moggia E, Mazzucco G, Giannakakis C, Honsova E, Sundelin BB, di Palma AM, Ferrario F, Gutierrez E, Asunis AM, Barratt J, Tardanico R, Perkowska-Ptasinska A, on behalf of the VALIGA study of the ERA-EDTA Immunonephrology Working Group (2014) Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments. Kidney Int 86(4):828\u2013836","journal-title":"Kidney Int"},{"issue":"1","key":"871_CR45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000441852","volume":"132","author":"J Feehally","year":"2016","unstructured":"Feehally J, Coppo R, Troyanov S, Bellur SS, Cattran D, Cook T, Roberts ISD, Verhave JC, Camilla R, Vergano L, Egido J, Wiecek A, Karkoszka H, Tesar V, Maixnerova D, Ots-Rosenberg M, Quaglia M, Rollino C, Magistroni R, Cusinato S, Cravero R, Peruzzi L, Lundberg S, Gesualdo L, Cancarini G, Feriozzi S, Ferrario F, on behalf of the VALIGA study of the ERA-EDTA Immunonephrology Working Group (2016) Tonsillectomy in a European cohort of 1,147 patients with IgA nephropathy. Nephron 132(1):15\u201324","journal-title":"Nephron"},{"issue":"8","key":"871_CR46","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1093\/ndt\/gfu020","volume":"29","author":"T Kawamura","year":"2014","unstructured":"Kawamura T, Yoshimura M, Miyazaki Y, Okamoto H, Kimura K, Hirano K, Matsushima M, Utsunomiya Y, Ogura M, Yokoo T, Okonogi H, Ishii T, Hamaguchi A, Ueda H, Furusu A, Horikoshi S, Suzuki Y, Shibata T, Yasuda T, Shirai S, Imasawa T, Kanozawa K, Wada A, Yamaji I, Miura N, Imai H, Kasai K, Soma J, Fujimoto S, Matsuo S, Tomino Y, The Special IgA Nephropathy Study Group (2014) A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy. Nephrol Dial Transplant 29(8):1546\u20131553","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"871_CR47","doi-asserted-by":"publisher","first-page":"e194772","DOI":"10.1001\/jamanetworkopen.2019.4772","volume":"2","author":"K Hirano","year":"2019","unstructured":"Hirano K, Matsuzaki K, Yasuda T, Nishikawa M, Yasuda Y, Koike K, Maruyama S, Yokoo T, Matsuo S, Kawamura T, Suzuki Y (2019) Association between tonsillectomy and outcomes in patients with immunoglobulin A nephropathy. JAMA Netw Open 2(5):e194772","journal-title":"JAMA Netw Open"},{"issue":"1","key":"871_CR48","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00467-017-3652-1","volume":"33","author":"R Coppo","year":"2018","unstructured":"Coppo R (2018) The gut-kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition. Pediatr Nephrol 33(1):53\u201361","journal-title":"Pediatr Nephrol"},{"issue":"11","key":"871_CR49","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/ng.3118","volume":"46","author":"K Kiryluk","year":"2014","unstructured":"Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S, Fischman C, Snyder HJ, Appel G, Izzi C, Viola BF, Dallera N, del Vecchio L, Barlassina C, Salvi E, Bertinetto FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G, Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, di Landro D, Santoro D, Pani A, Polci R, Feriozzi S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerov\u00e1 D, Tesar V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, P\u0105czek L, Zaniew M, Mizerska-Wasiak M, Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A, Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ, Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG (2014) Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet 46(11):1187\u20131196","journal-title":"Nat Genet"},{"key":"871_CR50","doi-asserted-by":"crossref","unstructured":"Sallustio F et al (2019) A new vision of IgA nephropathy: the missing link. Int J Mol Sci 21(1)","DOI":"10.3390\/ijms21010189"},{"issue":"2","key":"871_CR51","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.immuni.2018.08.011","volume":"49","author":"JJ Bunker","year":"2018","unstructured":"Bunker JJ, Bendelac A (2018) IgA responses to microbiota. Immunity 49(2):211\u2013224","journal-title":"Immunity"},{"issue":"3","key":"871_CR52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nrneph.2015.208","volume":"12","author":"J Floege","year":"2016","unstructured":"Floege J, Feehally J (2016) The mucosa-kidney axis in IgA nephropathy. Nat Rev Nephrol 12(3):147\u2013156","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"871_CR53","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","volume":"31","author":"AB Shreiner","year":"2015","unstructured":"Shreiner AB, Kao JY, Young VB (2015) The gut microbiome in health and in disease. Curr Opin Gastroenterol 31(1):69\u201375","journal-title":"Curr Opin Gastroenterol"},{"key":"871_CR54","doi-asserted-by":"crossref","unstructured":"Sallustio F et al (2020) High levels of gut-homing immunoglobulin A-positive+B lymphocytes support the pathogenic role of intestinal mucosal hyperresponsiveness in immunoglobulin A nephropathy patients. Nephrol Dial Transplant","DOI":"10.1093\/ndt\/gfaa264"},{"issue":"1","key":"871_CR55","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00109-016-1474-4","volume":"95","author":"JH Yiu","year":"2017","unstructured":"Yiu JH, Dorweiler B, Woo CW (2017) Interaction between gut microbiota and toll-like receptor: from immunity to metabolism. J Mol Med (Berl) 95(1):13\u201320","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"871_CR56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","volume":"122","author":"SK Mazmanian","year":"2005","unstructured":"Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122(1):107\u2013118","journal-title":"Cell"},{"issue":"1","key":"871_CR57","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1651-2227.1988.tb10609.x","volume":"77","author":"JC Davin","year":"1988","unstructured":"Davin JC, Forget P, Mahieu PR (1988) Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand 77(1):118\u2013124","journal-title":"Acta Paediatr Scand"},{"issue":"3","key":"871_CR58","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000187211","volume":"63","author":"G Rostoker","year":"1993","unstructured":"Rostoker G, Wirquin V, Terzidis H, Petit-Phar M, Chaumette MT, Delchier JC, Belghiti \u2020 D, Lang P, Dubert JM, Meignan M, Lagrue G, Weil B (1993) Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability. Nephron 63(3):286\u2013290","journal-title":"Nephron"},{"issue":"5","key":"871_CR59","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1093\/ndt\/gfm781","volume":"23","author":"W Qin","year":"2008","unstructured":"Qin W, Zhong X, Fan JM, Zhang YJ, Liu XR, Ma XY (2008) External suppression causes the low expression of the Cosmc gene in IgA nephropathy. Nephrol Dial Transplant 23(5):1608\u20131614","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"871_CR60","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1136\/jmg.40.2.104","volume":"40","author":"HJ Yoon","year":"2003","unstructured":"Yoon HJ, Shin JH, Yang SH, Chae DW, Kim H, Lee DS, Kim HL, Kim S, Lee JS, Kim YS (2003) Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. J Med Genet 40(2):104\u2013108","journal-title":"J Med Genet"},{"issue":"1","key":"871_CR61","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1365-2249.2009.04045.x","volume":"159","author":"R Coppo","year":"2010","unstructured":"Coppo R, Camilla R, Amore A, Peruzzi L, Dapr\u00c3 V, Loiacono E, Vatrano S, Rollino C, Sepe V, Rampino T, Dal Canton A (2010) Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy. Clin Exp Immunol 159(1):73\u201381","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"871_CR62","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s00467-014-2807-6","volume":"29","author":"ME Donadio","year":"2014","unstructured":"Donadio ME, Loiacono E, Peruzzi L, Amore A, Camilla R, Chiale F, Vergano L, Boido A, Conrieri M, Bianciotto M, Bosetti FM, Coppo R (2014) Toll-like receptors, immunoproteasome and regulatory T cells in children with Henoch-Schonlein purpura and primary IgA nephropathy. Pediatr Nephrol 29(9):1545\u20131551","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"871_CR63","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1172\/JCI45563","volume":"121","author":"DD McCarthy","year":"2011","unstructured":"McCarthy DD, Kujawa J, Wilson C, Papandile A, Poreci U, Porfilio EA, Ward L, Lawson MAE, Macpherson AJ, McCoy KD, Pei Y, Novak L, Lee JY, Julian BA, Novak J, Ranger A, Gommerman JL, Browning JL (2011) Mice overexpressing BAFF develop a commensal flora-dependent. IgA-associated nephropathy J Clin Invest 121(10):3991\u20134002","journal-title":"IgA-associated nephropathy J Clin Invest"},{"issue":"6","key":"871_CR64","doi-asserted-by":"publisher","first-page":"e99006","DOI":"10.1371\/journal.pone.0099006","volume":"9","author":"M De Angelis","year":"2014","unstructured":"De Angelis M et al (2014) Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN). PLoS One 9(6):e99006","journal-title":"PLoS One"},{"key":"871_CR65","doi-asserted-by":"publisher","first-page":"557368","DOI":"10.3389\/fcimb.2020.557368","volume":"10","author":"R Dong","year":"2020","unstructured":"Dong R, Bai M, Zhao J, Wang D, Ning X, Sun S (2020) A comparative study of the gut microbiota associated with immunoglobulin a nephropathy and membranous nephropathy. Front Cell Infect Microbiol 10:557368","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"871_CR66","doi-asserted-by":"publisher","first-page":"5573","DOI":"10.1021\/pr300637d","volume":"11","author":"EP Nyangale","year":"2012","unstructured":"Nyangale EP, Mottram DS, Gibson GR (2012) Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res 11(12):5573\u20135585","journal-title":"J Proteome Res"},{"issue":"4","key":"871_CR67","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0272-6386(12)80644-5","volume":"17","author":"R Coppo","year":"1991","unstructured":"Coppo R, Amore A, Roccatello D, Gianoglio B, Molino A, Piccoli G, Clarkson AR, Woodroffe AJ, Sakai H, Tomino Y (1991) IgA antibodies to dietary antigens and lectin-binding IgA in sera from Italian, Australian, and Japanese IgA nephropathy patients. Am J Kidney Dis 17(4):480\u2013487","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"871_CR68","first-page":"324","volume":"107","author":"H Helin","year":"1983","unstructured":"Helin H, Mustonen J, Reunala T, Pasternack A (1983) IgA nephropathy associated with celiac disease and dermatitis herpetiformis. Arch Pathol Lab Med 107(6):324\u2013327","journal-title":"Arch Pathol Lab Med"},{"key":"871_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2020.02.019","volume":"121","author":"L Abbad","year":"2020","unstructured":"Abbad L, Monteiro RC, Berthelot L (2020) Food antigens and transglutaminase 2 in IgA nephropathy: molecular links between gut and kidney. Mol Immunol 121:1\u20136","journal-title":"Mol Immunol"},{"issue":"10","key":"871_CR70","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1111\/j.1572-0241.2002.06025.x","volume":"97","author":"P Collin","year":"2002","unstructured":"Collin P, Syrjanen J, Partanen J, Pasternack A, Kaukinen K, Mustonen J (2002) Celiac disease and HLA DQ in patients with IgA nephropathy. Am J Gastroenterol 97(10):2572\u20132576","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"871_CR71","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/MCG.0b013e318284792e","volume":"47","author":"A Welander","year":"2013","unstructured":"Welander A, Sundelin B, Fored M, Ludvigsson JF (2013) Increased risk of IgA nephropathy among individuals with celiac disease. J Clin Gastroenterol 47(8):678\u2013683","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"871_CR72","first-page":"499","volume":"60","author":"R Coppo","year":"1989","unstructured":"Coppo R et al (1989) Gluten-induced experimental IgA glomerulopathy. Lab Investig 60(4):499\u2013506","journal-title":"Lab Investig"},{"issue":"2","key":"871_CR73","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/ki.2015.94","volume":"88","author":"C Papista","year":"2015","unstructured":"Papista C, Lechner S, Ben Mkaddem S, LeStang MB, Abbad L, Bex-Coudrat J, Pillebout E, Chemouny JM, Jablonski M, Flamant M, Daugas E, Vrtovsnik F, Yiangou M, Berthelot L, Monteiro RC (2015) Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction. Kidney Int 88(2):276\u2013285","journal-title":"Kidney Int"},{"issue":"4","key":"871_CR74","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1084\/jem.20112005","volume":"209","author":"L Berthelot","year":"2012","unstructured":"Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PHM, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogn\u00e9 M, Moura IC, Monteiro RC (2012) Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. J Exp Med 209(4):793\u2013806","journal-title":"J Exp Med"},{"issue":"3","key":"871_CR75","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00467-020-04475-w","volume":"36","author":"A Cambier","year":"2021","unstructured":"Cambier A, Gleeson PJ, Flament H, le Stang MB, Monteiro RC (2021) New therapeutic perspectives for IgA nephropathy in children. Pediatr Nephrol 36(3):497\u2013506","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"871_CR76","first-page":"72","volume":"26","author":"R Coppo","year":"1986","unstructured":"Coppo R, Basolo B, Rollino C, Roccatello D, Martina G, Amore A, Bongiorno G, Piccoli G (1986) Mediterranean diet and primary IgA nephropathy. Clin Nephrol 26(2):72\u201382","journal-title":"Clin Nephrol"},{"issue":"2","key":"871_CR77","first-page":"72","volume":"33","author":"R Coppo","year":"1990","unstructured":"Coppo R, Roccatello D, Amore A, Quattrocchio G, Molino A, Gianoglio B, Amoroso A, Bajardi P, Piccoli G (1990) Effects of a gluten-free diet in primary IgA nephropathy. Clin Nephrol 33(2):72\u201386","journal-title":"Clin Nephrol"},{"issue":"10 Suppl","key":"871_CR78","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1681\/ASN.V210s173","volume":"2","author":"R Coppo","year":"1992","unstructured":"Coppo R, Amore A, Roccatello D (1992) Dietary antigens and primary immunoglobulin A nephropathy. J Am Soc Nephrol 2(10 Suppl):S173\u2013S180","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"871_CR79","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1093\/ndt\/gfp133","volume":"24","author":"HK Smerud","year":"2009","unstructured":"Smerud HK, Fellstrom B, Hallgren R, Osagie S, Venge P, Kristjansson G (2009) Gluten sensitivity in patients with IgA nephropathy. Nephrol Dial Transplant 24(8):2476\u20132481","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"871_CR80","doi-asserted-by":"publisher","first-page":"364","DOI":"10.5414\/CNP74364","volume":"74","author":"H Kloster Smerud","year":"2010","unstructured":"Kloster Smerud H et al (2010) Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy. Clin Nephrol 74(5):364\u2013371","journal-title":"Clin Nephrol"},{"key":"871_CR81","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fnut.2020.00152","volume":"7","author":"G Serena","year":"2020","unstructured":"Serena G, D'Avino P, Fasano A (2020) Celiac disease and non-celiac wheat sensitivity: state of art of non-dietary therapies. Front Nutr 7:152","journal-title":"Front Nutr"},{"issue":"5","key":"871_CR82","doi-asserted-by":"publisher","first-page":"594","DOI":"10.4161\/19490976.2014.969635","volume":"5","author":"HJ Galipeau","year":"2014","unstructured":"Galipeau HJ, Verdu EF (2014) Gut microbes and adverse food reactions: focus on gluten related disorders. Gut Microbes 5(5):594\u2013605","journal-title":"Gut Microbes"},{"key":"871_CR83","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.3389\/fimmu.2018.02240","volume":"9","author":"L Vitetta","year":"2018","unstructured":"Vitetta L, Vitetta G, Hall S (2018) Immunological tolerance and function: associations between intestinal bacteria, probiotics, prebiotics, and phages. Front Immunol 9:2240","journal-title":"Front Immunol"},{"key":"871_CR84","doi-asserted-by":"crossref","unstructured":"Cosola C et al (2018) Nutrients, nutraceuticals, and xenobiotics affecting renal health. Nutrients 10(7)","DOI":"10.3390\/nu10070808"},{"issue":"1","key":"871_CR85","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MNH.0000000000000565","volume":"29","author":"G Caggiano","year":"2020","unstructured":"Caggiano G, Cosola C, di Leo V, Gesualdo M, Gesualdo L (2020) Microbiome modulation to correct uremic toxins and to preserve kidney functions. Curr Opin Nephrol Hypertens 29(1):49\u201356","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"871_CR86","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000496426","volume":"74","author":"C Maldonado Galdeano","year":"2019","unstructured":"Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, V\u00e9lez E, Perdig\u00f3n G (2019) Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab 74(2):115\u2013124","journal-title":"Ann Nutr Metab"},{"issue":"7","key":"871_CR87","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1093\/ndt\/gfy323","volume":"34","author":"JM Chemouny","year":"2019","unstructured":"Chemouny JM, Gleeson PJ, Abbad L, Lauriero G, Boedec E, le Roux K, Monot C, Bredel M, Bex-Coudrat J, Sannier A, Daugas E, Vrtovsnik F, Gesualdo L, Leclerc M, Berthelot L, Ben Mkaddem S, Lepage P, Monteiro RC (2019) Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice. Nephrol Dial Transplant 34(7):1135\u20131144","journal-title":"Nephrol Dial Transplant"},{"issue":"25","key":"871_CR88","doi-asserted-by":"publisher","first-page":"11462","DOI":"10.7150\/thno.49778","volume":"10","author":"JW He","year":"2020","unstructured":"He JW, Zhou XJ, Lv JC, Zhang H (2020) Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics 10(25):11462\u201311478","journal-title":"Theranostics"},{"issue":"2","key":"871_CR89","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.chom.2020.05.006","volume":"28","author":"SY Ting","year":"2020","unstructured":"Ting SY, Mart\u00ednez-Garc\u00eda E, Huang S, Bertolli SK, Kelly KA, Cutler KJ, Su ED, Zhi H, Tang Q, Radey MC, Raffatellu M, Peterson SB, de Lorenzo V, Mougous JD (2020) Targeted depletion of bacteria from mixed populations by programmable adhesion with antagonistic competitor cells. Cell Host Microbe 28(2):313\u2013321 e6","journal-title":"Cell Host Microbe"},{"key":"871_CR90","doi-asserted-by":"crossref","unstructured":"Bibbo S et al (2020) Fecal microbiota transplantation: screening and selection to choose the optimal donor. J Clin Med 9(6)","DOI":"10.3390\/jcm9061757"},{"key":"871_CR91","doi-asserted-by":"crossref","unstructured":"Barba C et al (2020) Effects of fecal microbiota transplantation on composition in mice with CKD. Toxins (Basel) 12(12)","DOI":"10.3390\/toxins12120741"},{"issue":"2","key":"871_CR92","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2215\/CJN.04660513","volume":"9","author":"JM Ambruzs","year":"2014","unstructured":"Ambruzs JM, Walker PD, Larsen CP (2014) The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clin J Am Soc Nephrol 9(2):265\u2013270","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"871_CR93","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1681\/ASN.2020060848","volume":"32","author":"J Rehnberg","year":"2021","unstructured":"Rehnberg J, Symreng A, Ludvigsson JF, Emilsson L (2021) Inflammatory bowel disease is more common in patients with IgA nephropathy and predicts progression of ESKD: a Swedish population-based cohort study. J Am Soc Nephrol 32(2):411\u2013423","journal-title":"J Am Soc Nephrol"},{"issue":"12 Suppl","key":"871_CR94","first-page":"12S","volume":"92","author":"M Robinson","year":"1997","unstructured":"Robinson M (1997) Optimizing therapy for inflammatory bowel disease. Am J Gastroenterol 92(12 Suppl):12S\u201317S","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"871_CR95","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1093\/ndt\/gfz249","volume":"35","author":"R Coppo","year":"2020","unstructured":"Coppo R, Mariat C (2020) Systemic corticosteroids and mucosal-associated lymphoid tissue-targeted therapy in immunoglobulin A nephropathy: insight from the NEFIGAN study. Nephrol Dial Transplant 35(8):1291\u20131294","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"871_CR96","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1093\/ndt\/gfr052","volume":"26","author":"HK Smerud","year":"2011","unstructured":"Smerud HK, Barany P, Lindstrom K, Fernstrom A, Sandell A, Pahlsson P, Fellstrom B (2011) New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria. Nephrol Dial Transplant 26(10):3237\u20133242","journal-title":"Nephrol Dial Transplant"},{"issue":"10084","key":"871_CR97","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/S0140-6736(17)30550-0","volume":"389","author":"BC Fellstrom","year":"2017","unstructured":"Fellstrom BC et al (2017) Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet 389(10084):2117\u20132127","journal-title":"Lancet"},{"issue":"8","key":"871_CR98","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1177\/0961203312437270","volume":"21","author":"R Willis","year":"2012","unstructured":"Willis R, Seif AM, McGwin G Jr, Martinez-Martinez LA, Gonz\u00e1lez EB, Dang N, Papalardo E, Liu J, Vil\u00e1 LM, Reveille JD, Alarc\u00f3n GS, Pierangeli SS (2012) Effect of hydroxychloroquine treatment on pro-inflammatory cytokines and disease activity in SLE patients: data from LUMINA (LXXV), a multiethnic US cohort. Lupus 21(8):830\u2013835","journal-title":"Lupus"},{"issue":"11","key":"871_CR99","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1159\/000509997","volume":"144","author":"E Gutierrez","year":"2020","unstructured":"Gutierrez E et al (2020) A personalized update on IgA nephropathy: a new vision and new future challenges. Nephron 144(11):555\u2013571","journal-title":"Nephron"},{"issue":"1","key":"871_CR100","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/j.ajkd.2019.01.026","volume":"74","author":"LJ Liu","year":"2019","unstructured":"Liu LJ, Yang YZ, Shi SF, Bao YF, Yang C, Zhu SN, Sui GL, Chen YQ, Lv JC, Zhang H (2019) Effects of hydroxychloroquine on proteinuria in IgA nephropathy: a randomized controlled trial. Am J Kidney Dis 74(1):15\u201322","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"871_CR101","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1053\/j.ajkd.2019.02.022","volume":"74","author":"J Floege","year":"2019","unstructured":"Floege J (2019) Antimalarials in IgA nephropathy: did our supportive therapy armamentarium just increase? Am J Kidney Dis 74(1):6\u20138","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"871_CR102","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.kint.2019.01.031","volume":"96","author":"JR Myette","year":"2019","unstructured":"Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG (2019) A proliferation inducing ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy. Kidney Int 96(1):104\u2013116","journal-title":"Kidney Int"},{"issue":"4","key":"871_CR103","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.ekir.2018.03.001","volume":"3","author":"C Hartono","year":"2018","unstructured":"Hartono C, Chung M, Perlman AS, Chevalier JM, Serur D, Seshan SV, Muthukumar T (2018) Bortezomib for reduction of proteinuria in IgA nephropathy. Kidney Int Rep 3(4):861\u2013866","journal-title":"Kidney Int Rep"},{"issue":"4","key":"871_CR104","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1681\/ASN.2016060640","volume":"28","author":"RA Lafayette","year":"2017","unstructured":"Lafayette RA, Canetta PA, Rovin BH, Appel GB, Novak J, Nath KA, Sethi S, Tumlin JA, Mehta K, Hogan M, Erickson S, Julian BA, Leung N, Enders FT, Brown R, Knoppova B, Hall S, Fervenza FC (2017) A randomized, controlled trial of rituximab in IgA nephropathy with proteinuria and renal dysfunction. J Am Soc Nephrol 28(4):1306\u20131313","journal-title":"J Am Soc Nephrol"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00871-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-021-00871-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-021-00871-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:24:05Z","timestamp":1706178245000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-021-00871-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["871"],"URL":"https:\/\/doi.org\/10.1007\/s00281-021-00871-y","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"17 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}