{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:09:19Z","timestamp":1791493759380,"version":"4.3.4"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK57993"],"award-info":[{"award-number":["DK57993"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008538","name":"PSC Partners Seeking a Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00281-022-00909-9","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T22:02:37Z","timestamp":1645135357000},"page":"527-544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target"],"prefix":"10.1007","volume":"44","author":[{"given":"Christy E.","family":"Trussoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"O\u2019Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3266-0831","authenticated-orcid":false,"given":"Nicholas F.","family":"LaRusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"909_CR1","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41551-019-0445-9","volume":"3","author":"DG Doherty","year":"2019","unstructured":"Doherty DG (2019) Antigen-specific immune tolerance\u2193\u2191 in the liver. Nat Biomed Eng 3:763\u2013765","journal-title":"Nat Biomed Eng"},{"key":"909_CR2","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1056\/NEJMra1909094","volume":"385","author":"G Schett","year":"2021","unstructured":"Schett G, McInnes IB, Neurath MF (2021) Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs. N Engl J Med 385:628\u2013639","journal-title":"N Engl J Med"},{"key":"909_CR3","doi-asserted-by":"publisher","first-page":"574276","DOI":"10.3389\/fimmu.2020.574276","volume":"11","author":"CE McQuitty","year":"2020","unstructured":"McQuitty CE, Williams R, Chokshi S, Urbani L (2020) Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment. Front Immunol 11:574276","journal-title":"Front Immunol"},{"key":"909_CR4","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1056\/NEJMra1506330","volume":"375","author":"KN Lazaridis","year":"2016","unstructured":"Lazaridis KN, LaRusso NF (2016) Primary Sclerosing Cholangitis. N Engl J Med 375:1161\u20131170","journal-title":"N Engl J Med"},{"key":"909_CR5","first-page":"194","volume":"31","author":"W Schoning","year":"2015","unstructured":"Schoning W, Schmeding M, Ulmer F, Andert A, Neumann U (2015) Liver Transplantation for Patients with Cholestatic Liver Diseases. Viszeralmedizin 31:194\u2013198","journal-title":"Viszeralmedizin"},{"key":"909_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","volume":"16","author":"JM Banales","year":"2019","unstructured":"Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ (2019) Cholangiocyte pathobiology. Nat Rev Gastroenterol Hepatol 16:269\u2013281","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"909_CR7","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.bbadis.2017.06.024","volume":"1864","author":"AC Cheung","year":"2018","unstructured":"Cheung AC, Lorenzo Pisarello MJ, LaRusso NF (2018) Pathobiology of biliary epithelia. Biochim Biophys Acta Mol Basis Dis 1864:1220\u20131231","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"909_CR8","doi-asserted-by":"publisher","first-page":"G1077","DOI":"10.1152\/ajpgi.00227.2012","volume":"303","author":"G Syal","year":"2012","unstructured":"Syal G, Fausther M, Dranoff JA (2012) Advances in cholangiocyte immunobiology. Am J Physiol Gastrointest Liver Physiol 303:G1077\u2013G1086","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"909_CR9","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.bbadis.2017.07.024","volume":"1864","author":"C Pinto","year":"2018","unstructured":"Pinto C, Giordano DM, Maroni L, Marzioni M (2018) Role of inflammation and proinflammatory cytokines in cholangiocyte pathophysiology. Biochim Biophys Acta Mol Basis Dis 1864:1270\u20131278","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"909_CR10","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/hep.31067","volume":"71","author":"ME Guicciardi","year":"2020","unstructured":"Guicciardi ME, Trussoni CE, LaRusso NF, Gores GJ (2020) The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis. Hepatology 71:741\u2013748","journal-title":"Hepatology"},{"key":"909_CR11","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/hep.30150","volume":"69","author":"K Sato","year":"2019","unstructured":"Sato K, Marzioni M, Meng F, Francis H, Glaser S, Alpini G (2019) Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances. Hepatology 69:420\u2013430","journal-title":"Hepatology"},{"key":"909_CR12","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/joim.13141","volume":"288","author":"JL Kirkland","year":"2020","unstructured":"Kirkland JL, Tchkonia T (2020) Senolytic drugs: from discovery to translation. J Intern Med 288:518\u2013536","journal-title":"J Intern Med"},{"key":"909_CR13","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","volume":"37","author":"I Ben-Porath","year":"2005","unstructured":"Ben-Porath I, Weinberg RA (2005) The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37:961\u2013976","journal-title":"Int J Biochem Cell Biol"},{"key":"909_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","volume":"47","author":"LJ Hickson","year":"2019","unstructured":"Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL (2019) Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine 47:446\u2013456","journal-title":"EBioMedicine"},{"key":"909_CR15","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.3748\/wjg.v25.i34.5069","volume":"25","author":"N Huda","year":"2019","unstructured":"Huda N, Liu G, Hong H, Yan S, Khambu B, Yin XM (2019) Hepatic senescence, the good and the bad. World J Gastroenterol 25:5069\u20135081","journal-title":"World J Gastroenterol"},{"key":"909_CR16","doi-asserted-by":"publisher","first-page":"101275","DOI":"10.1016\/j.smim.2019.04.003","volume":"40","author":"L Prata","year":"2018","unstructured":"Prata L, Ovsyannikova IG, Tchkonia T, Kirkland JL (2018) Senescent cell clearance by the immune system: Emerging therapeutic opportunities. Semin Immunol 40:101275","journal-title":"Semin Immunol"},{"key":"909_CR17","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","volume":"134","author":"V Krizhanovsky","year":"2008","unstructured":"Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657\u2013667","journal-title":"Cell"},{"key":"909_CR18","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1038\/s41467-021-24734-0","volume":"12","author":"Y Koda","year":"2021","unstructured":"Koda Y, Teratani T, Chu PS, Hagihara Y, Mikami Y, Harada Y, Tsujikawa H, Miyamoto K, Suzuki T, Taniki N, Sujino T, Sakamoto M, Kanai T, Nakamoto N (2021) CD8(+) tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells. Nat Commun 12:4474","journal-title":"Nat Commun"},{"key":"909_CR19","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1002\/hep.26993","volume":"59","author":"JH Tabibian","year":"2014","unstructured":"Tabibian JH, O\u2019Hara SP, Splinter PL, Trussoni CE, LaRusso NF (2014) Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis. Hepatology 59:2263\u20132275","journal-title":"Hepatology"},{"key":"909_CR20","doi-asserted-by":"crossref","unstructured":"Lysek-Gladysinska M, Wieczorek A, Jozwik A, Walaszczyk A, Jelonek K, Szczukiewicz-Markowska G, Horbanczuk OK, Pietrowska M, Widlak P, Gabrys D (2021)\u00a0Aging-related changes in the ultrastructure of hepatocytes and cardiomyocytes of elderly mice are enhanced in ApoE-deficient animals. Cells 10:502","DOI":"10.3390\/cells10030502"},{"key":"909_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12929-021-00718-6","volume":"28","author":"O Brochado","year":"2021","unstructured":"Brochado O, Martinez I, Berenguer J, Medrano L, Gonzalez-Garcia J, Jimenez-Sousa MA, Carrero A, Hontanon V, Navarro J, Guardiola JM, Fernandez-Rodriguez A, Resino S, Group GS (2021) HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV\/HCV-coinfected patients. J Biomed Sci 28:23","journal-title":"J Biomed Sci"},{"key":"909_CR22","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1038\/s41467-019-10335-5","volume":"10","author":"BI Pereira","year":"2019","unstructured":"Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN (2019) Senescent cells evade immune clearance via HLA-E-mediated NK and CD8(+) T cell inhibition. Nat Commun 10:2387","journal-title":"Nat Commun"},{"key":"909_CR23","doi-asserted-by":"publisher","first-page":"700790","DOI":"10.3389\/fimmu.2021.700790","volume":"12","author":"RA Campbell","year":"2021","unstructured":"Campbell RA, Docherty MH, Ferenbach DA, Mylonas KJ (2021) The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis. Front Immunol 12:700790","journal-title":"Front Immunol"},{"key":"909_CR24","doi-asserted-by":"publisher","first-page":"101280","DOI":"10.1016\/j.arr.2021.101280","volume":"67","author":"A Salminen","year":"2021","unstructured":"Salminen A (2021) Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases. Ageing Res Rev 67:101280","journal-title":"Ageing Res Rev"},{"key":"909_CR25","doi-asserted-by":"publisher","first-page":"101410","DOI":"10.1016\/j.arr.2021.101410","volume":"70","author":"S Borgoni","year":"2021","unstructured":"Borgoni S, Kudryashova KS, Burka K, de Magalhaes JP (2021) Targeting immune dysfunction in aging. Ageing Res Rev 70:101410","journal-title":"Ageing Res Rev"},{"key":"909_CR26","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3389\/fgene.2019.01229","volume":"10","author":"K Declerck","year":"2019","unstructured":"Declerck K, Vanden BW (2019) Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders. Front Genet 10:1229","journal-title":"Front Genet"},{"key":"909_CR27","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","volume":"594","author":"MJ Yousefzadeh","year":"2021","unstructured":"Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O\u2019Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ (2021) An aged immune system drives senescence and ageing of solid organs. Nature 594:100\u2013105","journal-title":"Nature"},{"key":"909_CR28","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1038\/s41467-018-07825-3","volume":"9","author":"Y Ovadya","year":"2018","unstructured":"Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V (2018) Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun 9:5435","journal-title":"Nat Commun"},{"key":"909_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-019-1136-4","volume":"20","author":"K So-Armah","year":"2019","unstructured":"So-Armah K, Freiberg M, Cheng D, Lim JK, Gnatienko N, Patts G, Doyle M, Fuster D, Lioznov D, Krupitsky E, Samet J (2019) Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study. BMC Gastroenterol 20:1","journal-title":"BMC Gastroenterol"},{"key":"909_CR30","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.3389\/fimmu.2018.02795","volume":"9","author":"EC Stahl","year":"2018","unstructured":"Stahl EC, Haschak MJ, Popovic B, Brown BN (2018) Macrophages in the Aging Liver and Age-Related Liver Disease. Front Immunol 9:2795","journal-title":"Front Immunol"},{"key":"909_CR31","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s10522-021-09936-9","volume":"22","author":"R Sharma","year":"2021","unstructured":"Sharma R (2021) Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology. Biogerontology 22:571\u2013587","journal-title":"Biogerontology"},{"key":"909_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.expneurol.2015.08.001","volume":"273","author":"B Zhang","year":"2015","unstructured":"Zhang B, Bailey WM, Braun KJ, Gensel JC (2015) Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury. Exp Neurol 273:83\u201391","journal-title":"Exp Neurol"},{"key":"909_CR33","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1474-9726.2012.00851.x","volume":"11","author":"AC Hearps","year":"2012","unstructured":"Hearps AC, Martin GE, Angelovich TA, Cheng WJ, Maisa A, Landay AL, Jaworowski A, Crowe SM (2012) Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 11:867\u2013875","journal-title":"Aging Cell"},{"key":"909_CR34","doi-asserted-by":"crossref","unstructured":"Behmoaras J, Gil J (2021)\u00a0Similarities and interplay between senescent cells and macrophages. J Cell Biol 220:202010162","DOI":"10.1083\/jcb.202010162"},{"key":"909_CR35","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1053\/j.sempedsurg.2012.05.003","volume":"21","author":"AG Feldman","year":"2012","unstructured":"Feldman AG, Mack CL (2012) Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg 21:192\u2013200","journal-title":"Semin Pediatr Surg"},{"key":"909_CR36","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.jpedsurg.2012.01.065","volume":"47","author":"AV Garcia","year":"2012","unstructured":"Garcia AV, Cowles RA, Kato T, Hardy MA (2012) Morio Kasai: a remarkable impact beyond the Kasai procedure. J Pediatr Surg 47:1023\u20131027","journal-title":"J Pediatr Surg"},{"key":"909_CR37","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/hep.29905","volume":"68","author":"JA Bezerra","year":"2018","unstructured":"Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ (2018) Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century. Hepatology 68:1163\u20131173","journal-title":"Hepatology"},{"key":"909_CR38","doi-asserted-by":"publisher","first-page":"720841","DOI":"10.3389\/fimmu.2021.720841","volume":"12","author":"X Pang","year":"2021","unstructured":"Pang X, Cao J, Chen S, Gao Z, Liu G, Chong Y, Chen Z, Gong J, Li X (2021) Unsupervised Clustering Reveals Distinct Subtypes of Biliary Atresia Based on Immune Cell Types and Gene Expression. Front Immunol 12:720841","journal-title":"Front Immunol"},{"key":"909_CR39","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1053\/j.gastro.2007.04.032","volume":"133","author":"CL Mack","year":"2007","unstructured":"Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP (2007) Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology 133:278\u2013287","journal-title":"Gastroenterology"},{"key":"909_CR40","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.jpedsurg.2004.07.010","volume":"39","author":"J Feng","year":"2004","unstructured":"Feng J, Li M, Gu W, Tang H, Yu S (2004) The aberrant expression of HLA-DR in intrahepatic bile ducts in patients with biliary atresia: an immunohistochemistry and immune electron microscopy study. J Pediatr Surg 39:1658\u20131662","journal-title":"J Pediatr Surg"},{"key":"909_CR41","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.jpedsurg.2015.02.005","volume":"50","author":"R Hill","year":"2015","unstructured":"Hill R, Quaglia A, Hussain M, Hadzic N, Mieli-Vergani G, Vergani D, Davenport M (2015) Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome. J Pediatr Surg 50:1297\u20131303","journal-title":"J Pediatr Surg"},{"key":"909_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.humimm.2004.11.004","volume":"66","author":"T Yuasa","year":"2005","unstructured":"Yuasa T, Tsuji H, Kimura S, Niwa N, Yurugi K, Egawa H, Tanaka K, Maruya E, Saji HO, Asano H, Maekawa T (2005) Human leukocyte antigens in Japanese patients with biliary atresia: retrospective analysis of patients who underwent living donor liver transplantation. Hum Immunol 66:295\u2013300","journal-title":"Hum Immunol"},{"key":"909_CR43","doi-asserted-by":"crossref","unstructured":"Mohanty SK, Donnelly B, Temple H, Bondoc A, McNeal M, Tiao G. 2021. T-bet deficiency attenuates bile duct injury in experimental biliary atresia. Cells 10:3461","DOI":"10.3390\/cells10123461"},{"key":"909_CR44","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s12887-021-02794-x","volume":"21","author":"X Guo","year":"2021","unstructured":"Guo X, Xu Y, Luo W, Fang R, Cai L, Wang P, Zhang Y, Wen Z, Xu Y (2021) Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-gamma expression in T cells in infants and neonatal mice. BMC Pediatr 21:317","journal-title":"BMC Pediatr"},{"key":"909_CR45","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/hep.21701","volume":"46","author":"B Narayanaswamy","year":"2007","unstructured":"Narayanaswamy B, Gonde C, Tredger JM, Hussain M, Vergani D, Davenport M (2007) Serial circulating markers of inflammation in biliary atresia\u2013evolution of the post-operative inflammatory process. Hepatology 46:180\u2013187","journal-title":"Hepatology"},{"key":"909_CR46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","volume":"509","author":"JM van Deursen","year":"2014","unstructured":"van Deursen JM (2014) The role of senescent cells in ageing. Nature 509:439\u2013446","journal-title":"Nature"},{"key":"909_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ebiom.2017.03.027","volume":"21","author":"S Victorelli","year":"2017","unstructured":"Victorelli S, Passos JF (2017) Telomeres and Cell Senescence - Size Matters Not. EBioMedicine 21:14\u201320","journal-title":"EBioMedicine"},{"key":"909_CR48","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1007\/s00268-012-1453-z","volume":"36","author":"Y Sanada","year":"2012","unstructured":"Sanada Y, Aida J, Kawano Y, Nakamura K, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K (2012) Hepatocellular telomere length in biliary atresia measured by Q-FISH. World J Surg 36:908\u2013916","journal-title":"World J Surg"},{"key":"909_CR49","doi-asserted-by":"publisher","first-page":"e0134689","DOI":"10.1371\/journal.pone.0134689","volume":"10","author":"W Udomsinprasert","year":"2015","unstructured":"Udomsinprasert W, Poovorawan Y, Chongsrisawat V, Vejchapipat P, Zhan D, Honsawek S (2015) Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia. PLoS One 10:e0134689","journal-title":"PLoS One"},{"key":"909_CR50","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1111\/his.13476","volume":"72","author":"M Sasaki","year":"2018","unstructured":"Sasaki M, Kuo FY, Huang CC, Swanson PE, Chen CL, Chuang JH, Yeh MM (2018) Increased expression of senescence-associated cell cycle regulators in the progression of biliary atresia: an immunohistochemical study. Histopathology 72:1164\u20131171","journal-title":"Histopathology"},{"key":"909_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1055\/s-0039-1697617","volume":"40","author":"A Lleo","year":"2020","unstructured":"Lleo A, Leung PSC, Hirschfield GM, Gershwin EM (2020) The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review. Semin Liver Dis 40:34\u201348","journal-title":"Semin Liver Dis"},{"key":"909_CR52","doi-asserted-by":"publisher","first-page":"102328","DOI":"10.1016\/j.jaut.2019.102328","volume":"105","author":"B Terziroli Beretta-Piccoli","year":"2019","unstructured":"Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Bjornsson E, Bowlus C, Carbone M, Chazouilleres O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME (2019) The challenges of primary biliary cholangitis: What is new and what needs to be done. J Autoimmun 105:102328","journal-title":"J Autoimmun"},{"key":"909_CR53","doi-asserted-by":"publisher","first-page":"111754","DOI":"10.1016\/j.biopha.2021.111754","volume":"140","author":"H Li","year":"2021","unstructured":"Li H, Guan Y, Han C, Zhang Y, Liu Q, Wei W, Ma Y (2021) The pathogenesis, models and therapeutic advances of primary biliary cholangitis. Biomed Pharmacother 140:111754","journal-title":"Biomed Pharmacother"},{"key":"909_CR54","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1136\/gut.47.4.586","volume":"47","author":"GH Haydon","year":"2000","unstructured":"Haydon GH, Neuberger J (2000) PBC: an infectious disease? Gut 47:586\u2013588","journal-title":"Gut"},{"key":"909_CR55","doi-asserted-by":"publisher","first-page":"102377","DOI":"10.1016\/j.jaut.2019.102377","volume":"107","author":"M Sasaki","year":"2020","unstructured":"Sasaki M, Sato Y, Nakanuma Y (2020) Increased p16(INK4a)-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis. J Autoimmun 107:102377","journal-title":"J Autoimmun"},{"key":"909_CR56","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1002\/art.40576","volume":"70","author":"J Wang","year":"2018","unstructured":"Wang J, Dai M, Cui Y, Hou G, Deng J, Gao X, Liao Z, Liu Y, Meng Y, Wu L, Yao C, Wang Y, Qian J, Guo Q, Ding H, Qu B, Shen N (2018) Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP-AMP Synthase\/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes. Arthritis Rheumatol 70:2036\u20132045","journal-title":"Arthritis Rheumatol"},{"key":"909_CR57","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nature24050","volume":"550","author":"Z Dou","year":"2017","unstructured":"Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim K, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL (2017) Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550:402\u2013406","journal-title":"Nature"},{"key":"909_CR58","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1002\/hep4.1497","volume":"4","author":"K Ueno","year":"2020","unstructured":"Ueno K, Aiba Y, Hitomi Y, Shimoda S, Nakamura H, Gervais O, Kawai Y, Kawashima M, Nishida N, Kohn SS, Kojima K, Katsushima S, Naganuma A, Sugi K, Komatsu T, Mannami T, Matsushita K, Yoshizawa K, Makita F, Nikami T, Nishimura H, Kouno H, Kouno H, Ohta H, Komura T, Tsuruta S, Yamauchi K, Kobata T, Kitasato A, Kuroki T, Abiru S, Nagaoka S, Komori A, Yatsuhashi H, Migita K, Ohira H, Tanaka A, Takikawa H, Nagasaki M, Tokunaga K, Nakamura M, Japan P-GCi. (2020) Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis. Hepatol Commun 4:724\u2013738","journal-title":"Hepatol Commun"},{"key":"909_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2017.03.008","volume":"83","author":"K Chen","year":"2017","unstructured":"Chen K, Liu J, Cao X (2017) Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review. J Autoimmun 83:1\u201311","journal-title":"J Autoimmun"},{"key":"909_CR60","doi-asserted-by":"publisher","first-page":"11413","DOI":"10.1038\/s41598-021-91016-6","volume":"11","author":"M Sasaki","year":"2021","unstructured":"Sasaki M, Sato Y, Nakanuma Y (2021) Interferon-induced protein with tetratricopeptide repeats 3 may be a key factor in primary biliary cholangitis. Sci Rep 11:11413","journal-title":"Sci Rep"},{"key":"909_CR61","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.4049\/jimmunol.1100963","volume":"187","author":"XY Liu","year":"2011","unstructured":"Liu XY, Chen W, Wei B, Shan YF, Wang C (2011) IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J Immunol 187:2559\u20132568","journal-title":"J Immunol"},{"key":"909_CR62","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jhep.2010.03.008","volume":"53","author":"M Sasaki","year":"2010","unstructured":"Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y (2010) Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis. J Hepatol 53:318\u2013325","journal-title":"J Hepatol"},{"key":"909_CR63","doi-asserted-by":"crossref","unstructured":"Barron-Millar B, Ogle L, Mells G, Flack S, Badrock J, Sandford R, Kirby J, Palmer J, Jopson L, Brain J, Smith GR, Rushton S, Hegade VS, Jones R, Rushbrook S, Thorburn D, Ryder S, Hirschfield G, Consortium U-PR, Dyson JK, Jones DEJ (2021)\u00a0The serum proteome and ursodeoxycholic acid response in primary biliary cholangitis. Hepatology 74:3269","DOI":"10.1002\/hep.32011"},{"key":"909_CR64","doi-asserted-by":"crossref","unstructured":"Chen HW, Lin CI, Chuang YH (2021)\u00a0Interleukin-30 suppresses not only CD4(+) T cells but also regulatory T cells in murine primary biliary cholangitis. Biomedicines 9:1031","DOI":"10.3390\/biomedicines9081031"},{"key":"909_CR65","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/jir.2013.0075","volume":"34","author":"A Landi","year":"2014","unstructured":"Landi A, Weismuller TJ, Lankisch TO, Santer DM, Tyrrell DL, Manns MP, Houghton M (2014) Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis. J Interferon Cytokine Res 34:204\u2013214","journal-title":"J Interferon Cytokine Res"},{"key":"909_CR66","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/eji.202048589","volume":"51","author":"S Shimoyama","year":"2021","unstructured":"Shimoyama S, Kawata K, Ohta K, Chida T, Suzuki T, Tsuneyama K, Shimoda S, Kurono N, Leung PSC, Gershwin ME, Suda T, Kobayashi Y (2021) Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-gamma and CX3CL1 production in primary biliary cholangitis. Eur J Immunol 51:1519\u20131530","journal-title":"Eur J Immunol"},{"key":"909_CR67","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1056\/NEJMra043898","volume":"353","author":"MM Kaplan","year":"2005","unstructured":"Kaplan MM, Gershwin ME (2005) Primary biliary cirrhosis. N Engl J Med 353:1261\u20131273","journal-title":"N Engl J Med"},{"key":"909_CR68","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/hep.24194","volume":"53","author":"S Shimoda","year":"2011","unstructured":"Shimoda S, Harada K, Niiro H, Shirabe K, Taketomi A, Maehara Y, Tsuneyama K, Nakanuma Y, Leung P, Ansari AA, Gershwin ME, Akashi K (2011) Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology 53:1270\u20131281","journal-title":"Hepatology"},{"key":"909_CR69","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.jhep.2020.06.033","volume":"73","author":"M Deeb","year":"2020","unstructured":"Deeb M, Karlsen TH, Hirschfield GM (2020) The 6 C\u2019s of primary sclerosing cholangitis. J Hepatol 73:1255\u20131256","journal-title":"J Hepatol"},{"key":"909_CR70","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1136\/gutjnl-2018-317993","volume":"68","author":"MH Chapman","year":"2019","unstructured":"Chapman MH, Thorburn D, Hirschfield GM, Webster GGJ, Rushbrook SM, Alexander G, Collier J, Dyson JK, Jones DE, Patanwala I, Thain C, Walmsley M, Pereira SP (2019) British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis. Gut 68:1356\u20131378","journal-title":"Gut"},{"key":"909_CR71","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/labinvest.2014.94","volume":"94","author":"JH Tabibian","year":"2014","unstructured":"Tabibian JH, Trussoni CE, O\u2019Hara SP, Splinter PL, Heimbach JK, LaRusso NF (2014) Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis. Lab Invest 94:1126\u20131133","journal-title":"Lab Invest"},{"key":"909_CR72","doi-asserted-by":"publisher","first-page":"100286","DOI":"10.1016\/j.jhepr.2021.100286","volume":"3","author":"N Cazzagon","year":"2021","unstructured":"Cazzagon N, Sarcognato S, Floreani A, Corra G, De Martin S, Guzzardo V, Russo FP, Guido M (2021) Cholangiocyte senescence in primary sclerosing cholangitis is associated with disease severity and prognosis. JHEP Rep 3:100286","journal-title":"JHEP Rep"},{"key":"909_CR73","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1074\/jbc.M117.777409","volume":"292","author":"SP O'Hara","year":"2017","unstructured":"O\u2019Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF (2017) ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem 292:4833\u20134846","journal-title":"J Biol Chem"},{"key":"909_CR74","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41467-018-03299-5","volume":"9","author":"S Ferreira-Gonzalez","year":"2018","unstructured":"Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O\u2019Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ (2018) Paracrine cellular senescence exacerbates biliary injury and impairs regeneration. Nat Commun 9:1020","journal-title":"Nat Commun"},{"key":"909_CR75","doi-asserted-by":"crossref","unstructured":"Zimmer CL, von Seth E, Buggert M, Strauss O, Hertwig L, Nguyen S, Wong AYW, Zotter C, Berglin L, Michaelsson J, Hansson MR, Arnelo U, Sparrelid E, Ellis ECS, Soderholm JD, Keita AV, Holm K, Ozenci V, Hov JR, Mold JE, Cornillet M, Ponzetta A, Bergquist A, Bjorkstrom NK (2021)\u00a0A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells. Sci Transl Med 13:3107","DOI":"10.1126\/scitranslmed.abb3107"},{"key":"909_CR76","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1136\/gutjnl-2017-314249","volume":"66","author":"SP O'Hara","year":"2017","unstructured":"O\u2019Hara SP, Karlsen TH, LaRusso NF (2017) Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? Gut 66:1873\u20131877","journal-title":"Gut"},{"key":"909_CR77","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.jhep.2018.05.018","volume":"69","author":"ME Guicciardi","year":"2018","unstructured":"Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O\u2019Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ (2018) Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. J Hepatol 69:676\u2013686","journal-title":"J Hepatol"},{"key":"909_CR78","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3727\/105221620X15960509906371","volume":"20","author":"D Kundu","year":"2020","unstructured":"Kundu D, Kennedy L, Meadows V, Baiocchi L, Alpini G, Francis H (2020) The Dynamic Interplay Between Mast Cells, Aging\/Cellular Senescence, and Liver Disease. Gene Expr 20:77\u201388","journal-title":"Gene Expr"},{"key":"909_CR79","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1001\/jama.2018.12440","volume":"320","author":"T Tchkonia","year":"2018","unstructured":"Tchkonia T, Kirkland JL (2018) Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies. JAMA 320:1319\u20131320","journal-title":"JAMA"},{"key":"909_CR80","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","volume":"36","author":"MJ Yousefzadeh","year":"2018","unstructured":"Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ (2018) Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 36:18\u201328","journal-title":"EBioMedicine"},{"key":"909_CR81","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2021.05.003","volume":"171","author":"SM Lagoumtzi","year":"2021","unstructured":"Lagoumtzi SM, Chondrogianni N (2021) Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases. Free Radic Biol Med 171:169\u2013190","journal-title":"Free Radic Biol Med"},{"key":"909_CR82","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/cas.13618","volume":"109","author":"Z Chen","year":"2018","unstructured":"Chen Z, Hu K, Feng L, Su R, Lai N, Yang Z, Kang S (2018) Senescent cells re-engineered to express soluble programmed death receptor-1 for inhibiting programmed death receptor-1\/programmed death ligand-1 as a vaccination approach against breast cancer. Cancer Sci 109:1753\u20131763","journal-title":"Cancer Sci"},{"key":"909_CR83","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1038\/s41591-019-0668-z","volume":"25","author":"S Khan","year":"2019","unstructured":"Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D (2019) A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25:1938\u20131947","journal-title":"Nat Med"},{"key":"909_CR84","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/ggi.13851","volume":"20","author":"H Nakagami","year":"2020","unstructured":"Nakagami H (2020) Cellular senescence and senescence-associated T cells as a potential therapeutic target. Geriatr Gerontol Int 20:97\u2013100","journal-title":"Geriatr Gerontol Int"},{"key":"909_CR85","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","volume":"583","author":"C Amor","year":"2020","unstructured":"Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW (2020) Senolytic CAR T cells reverse senescence-associated pathologies. Nature 583:127\u2013132","journal-title":"Nature"},{"key":"909_CR86","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12964-021-00731-0","volume":"19","author":"M Raffaele","year":"2021","unstructured":"Raffaele M, Kovacovicova K, Frohlich J, Lo Re O, Giallongo S, Oben JA, Faldyna M, Leva L, Giannone AG, Cabibi D, Vinciguerra M (2021) Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. Cell Commun Signal 19:44","journal-title":"Cell Commun Signal"},{"key":"909_CR87","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","volume":"40","author":"JN Justice","year":"2019","unstructured":"Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL (2019) Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine 40:554\u2013563","journal-title":"EBioMedicine"},{"key":"909_CR88","doi-asserted-by":"publisher","first-page":"100250","DOI":"10.1016\/j.jhepr.2021.100250","volume":"3","author":"M Alsuraih","year":"2021","unstructured":"Alsuraih M, O\u2019Hara SP, Woodrum JE, Pirius NE, LaRusso NF (2021) Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 (-\/-) mouse. JHEP Rep 3:100250","journal-title":"JHEP Rep"},{"key":"909_CR89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3727\/105221620X15889714507961","volume":"20","author":"K Kyritsi","year":"2020","unstructured":"Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G (2020) Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2(\/) Mouse Model of Primary Sclerosing Cholangitis. Gene Expr 20:89\u2013103","journal-title":"Gene Expr"},{"key":"909_CR90","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/hep.29464","volume":"67","author":"A Moncsek","year":"2018","unstructured":"Moncsek A, Al-Suraih MS, Trussoni CE, O\u2019Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Mullhaupt B, LaRusso NF, Mertens JC (2018) Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2(-\/-) ) mice. Hepatology 67:247\u2013259","journal-title":"Hepatology"},{"key":"909_CR91","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature10600","volume":"479","author":"DJ Baker","year":"2011","unstructured":"Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232\u2013236","journal-title":"Nature"},{"key":"909_CR92","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fmed.2019.00332","volume":"6","author":"C Pinto","year":"2019","unstructured":"Pinto C, Ninfole E, Benedetti A, Maroni L, Marzioni M (2019) Aging-Related Molecular Pathways in Chronic Cholestatic Conditions. Front Med (Lausanne) 6:332","journal-title":"Front Med (Lausanne)"},{"key":"909_CR93","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.2217\/epi-2020-0048","volume":"12","author":"RM Moore","year":"2020","unstructured":"Moore RM, Sun Z, Juran BD, Lazaridis KN (2020) Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease. Epigenomics 12:1363\u20131375","journal-title":"Epigenomics"},{"key":"909_CR94","doi-asserted-by":"publisher","first-page":"100060","DOI":"10.1016\/j.jhepr.2019.11.004","volume":"2","author":"M Trauner","year":"2020","unstructured":"Trauner M, Gindin Y, Jiang Z, Chung C, Subramanian GM, Myers RP, Gulamhusein A, Kowdley KV, Levy C, Goodman Z, Manns MP, Muir AJ, Bowlus CL (2020) Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis. JHEP Rep 2:100060","journal-title":"JHEP Rep"},{"key":"909_CR95","doi-asserted-by":"publisher","first-page":"686320","DOI":"10.3389\/fgene.2021.686320","volume":"12","author":"A Hartmann","year":"2021","unstructured":"Hartmann A, Hartmann C, Secci R, Hermann A, Fuellen G, Walter M (2021) Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring. Front Genet 12:686320","journal-title":"Front Genet"},{"key":"909_CR96","doi-asserted-by":"crossref","unstructured":"Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK (2020)\u00a0The senescence-associated secretome as an indicator of age and medical risk. JCI Insight 5:133668","DOI":"10.1172\/jci.insight.133668"},{"key":"909_CR97","doi-asserted-by":"publisher","first-page":"594137","DOI":"10.3389\/fmed.2020.594137","volume":"7","author":"F Al-Mudares","year":"2020","unstructured":"Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K (2020) Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan. Front Med (Lausanne) 7:594137","journal-title":"Front Med (Lausanne)"},{"key":"909_CR98","doi-asserted-by":"publisher","first-page":"685139","DOI":"10.3389\/fimmu.2021.685139","volume":"12","author":"C Picon","year":"2021","unstructured":"Picon C, Tejeda-Velarde A, Fernandez-Velasco JI, Comabella M, Alvarez-Lafuente R, Quintana E, Sainz de la Maza S, Monreal E, Villarrubia N, Alvarez-Cermeno JC, Dominguez-Mozo MI, Ramio-Torrenta L, Rodriguez-Martin E, Roldan E, Aladro Y, Medina S, Espino M, Masjuan J, Matute-Blanch C, Munoz-San Martin M, Espejo C, Guaza C, Muriel A, Costa-Frossard L, Villar LM (2021) Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis. Front Immunol 12:685139","journal-title":"Front Immunol"},{"key":"909_CR99","doi-asserted-by":"publisher","first-page":"e13415","DOI":"10.1111\/acel.13415","volume":"20","author":"DA Englund","year":"2021","unstructured":"Englund DA, Sakamoto AE, Fritsche CM, Heeren AA, Zhang X, Kotajarvi BR, Lecy DR, Yousefzadeh MJ, Schafer MJ, White TA, Atkinson EJ, LeBrasseur NK (2021) Exercise reduces circulating biomarkers of cellular senescence in humans. Aging Cell 20:e13415","journal-title":"Aging Cell"},{"key":"909_CR100","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1002\/1878-0261.12807","volume":"15","author":"HL Ou","year":"2021","unstructured":"Ou HL, Hoffmann R, Gonzalez-Lopez C, Doherty GJ, Korkola JE, Munoz-Espin D (2021) Cellular senescence in cancer: from mechanisms to detection. Mol Oncol 15:2634\u20132671","journal-title":"Mol Oncol"},{"key":"909_CR101","doi-asserted-by":"publisher","first-page":"15783","DOI":"10.1038\/s41598-021-95062-y","volume":"11","author":"SH Yeh","year":"2021","unstructured":"Yeh SH, Lin CH, Yang YJ, Lin LW, Tseng CW, Yang KD (2021) Higher senescence associated secretory phenotype and lower defense mediator in urinary extracellular vesicles of elders with and without Parkinson disease. Sci Rep 11:15783","journal-title":"Sci Rep"},{"key":"909_CR102","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.jhep.2017.01.019","volume":"66","author":"M Vesterhus","year":"2017","unstructured":"Vesterhus M, Holm A, Hov JR, Nygard S, Schrumpf E, Melum E, Thorbjornsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers S, Vatn M, Schaap FG, Jansen PLM, Ueland T, Rosjo H, Moum B, Ponsioen CY, Boberg KM, Farkkila M, Karlsen TH, Lund-Johansen F (2017) Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. J Hepatol 66:1214\u20131222","journal-title":"J Hepatol"},{"key":"909_CR103","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1016\/j.celrep.2017.02.012","volume":"18","author":"V Rapisarda","year":"2017","unstructured":"Rapisarda V, Borghesan M, Miguela V, Encheva V, Snijders AP, Lujambio A, O\u2019Loghlen A (2017) Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-beta Pathway. Cell Rep 18:2480\u20132493","journal-title":"Cell Rep"},{"key":"909_CR104","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/ncb3397","volume":"18","author":"M Hoare","year":"2016","unstructured":"Hoare M, Ito Y, Kang TW, Weekes MP, Matheson NJ, Patten DA, Shetty S, Parry AJ, Menon S, Salama R, Antrobus R, Tomimatsu K, Howat W, Lehner PJ, Zender L, Narita M (2016) NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol 18:979\u2013992","journal-title":"Nat Cell Biol"},{"key":"909_CR105","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","volume":"133","author":"T Kuilman","year":"2008","unstructured":"Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133:1019\u20131031","journal-title":"Cell"},{"key":"909_CR106","doi-asserted-by":"publisher","first-page":"e3000599","DOI":"10.1371\/journal.pbio.3000599","volume":"18","author":"N Basisty","year":"2020","unstructured":"Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B (2020) A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol 18:e3000599","journal-title":"PLoS Biol"},{"key":"909_CR107","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/gerona\/glab028","volume":"76","author":"S Romashkan","year":"2021","unstructured":"Romashkan S, Chang H, Hadley EC (2021) National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials. J Gerontol A Biol Sci Med Sci 76:1144\u20131152","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"909_CR108","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1186\/s12885-020-07383-2","volume":"20","author":"MT Bourlon","year":"2020","unstructured":"Bourlon MT, Velazquez HE, Hinojosa J, Orozco L, Rios-Corzo R, Lima G, Llorente L, Hernandez-Ramirez DF, Valentin-Cortez FJ, Medina-Rangel I, Atisha-Fregoso Y (2020) Immunosenescence profile and expression of the aging biomarker (p16(INK4a)) in testicular cancer survivors treated with chemotherapy. BMC Cancer 20:882","journal-title":"BMC Cancer"}],"updated-by":[{"DOI":"10.1007\/s00281-022-00930-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000}}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-022-00909-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-022-00909-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-022-00909-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T15:46:48Z","timestamp":1657036008000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-022-00909-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":108,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["909"],"URL":"https:\/\/doi.org\/10.1007\/s00281-022-00909-9","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00281-022-00930-y","asserted-by":"object"}]},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]},"assertion":[{"value":"19 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00281-022-00930-y","URL":"https:\/\/doi.org\/10.1007\/s00281-022-00930-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}