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MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or \u201cunconventional\u201d T cells. The specificity of their antigen receptor (T cell receptor or TCR) is for the conserved major histocompatibility complex (MHC)-related molecule MR1, which presents a modified bacterial metabolite from the vitamin B2 biosynthesis pathway \u2013 this allows them to respond in the presence of many bacteria or yeast. MAIT cells also possess an array of cytokine receptors, which allows triggering independently of the TCR. The combination of such signals drives their functionality \u2013 this means they can respond to a range of stimuli and likely play a role not only in infection or inflammation, but also under homeostatic conditions.<\/jats:p>\n                  <jats:p>In this review, we will look at the question of what MAIT cells are doing in the normal liver and how they behave in the setting of disease. These questions are of relevance because MAIT cells are such a distinctive cell type enriched in the liver under normal conditions, and their modulation could be of therapeutic benefit. The recent discovery that they appear to be involved in liver fibrosis is particularly of interest in this context.<\/jats:p>","DOI":"10.1007\/s00281-022-00949-1","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T16:02:50Z","timestamp":1654012970000},"page":"429-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["MAIT cells in liver inflammation and fibrosis"],"prefix":"10.1007","volume":"44","author":[{"given":"Hema","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Joseph","family":"Lett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-9161","authenticated-orcid":false,"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0356-8836","authenticated-orcid":false,"given":"Magdalena","family":"Filipowicz Sinnreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"949_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1136\/bmj.4.5580.645","volume":"4","author":"RY Calne","year":"1967","unstructured":"Calne RY, White HJ, Yoffa DE, Binns RM, Maginn RR, Herbertson RM, Millard PR, Molina VP, Davis DR (1967) Prolonged survival of liver transplants in the pig. 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