{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:25:09Z","timestamp":1793669109454,"version":"4.5.1"},"reference-count":150,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX003651"],"award-info":[{"award-number":["I01 BX003651"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["118777"],"award-info":[{"award-number":["118777"]}]},{"name":"NIH","award":["136779"],"award-info":[{"award-number":["136779"]}]},{"name":"NIH","award":["131453"],"award-info":[{"award-number":["131453"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s00281-022-00975-z","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:03:46Z","timestamp":1670231026000},"page":"329-346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Regulatory T lymphocytes as a therapy for ischemic stroke"],"prefix":"10.1007","volume":"45","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus W.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimi","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Junagade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-6243","authenticated-orcid":false,"given":"Xiaoming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"975_CR1","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.166.3906.753","volume":"166","author":"Y Nishizuka","year":"1969","unstructured":"Nishizuka Y, Sakakura T (1969) Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 166:753\u2013755","journal-title":"Science"},{"key":"975_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF00344296","volume":"14","author":"A Kojima","year":"1981","unstructured":"Kojima A, Prehn RT (1981) Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 14:15\u201327","journal-title":"Immunogenetics"},{"key":"975_CR3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"S Hori","year":"2003","unstructured":"Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057\u20131061","journal-title":"Science"},{"key":"975_CR4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41577-021-00519-w","volume":"21","author":"AR Munoz-Rojas","year":"2021","unstructured":"Munoz-Rojas AR, Mathis D (2021) Tissue regulatory T cells: regulatory chameleons. Nat Rev Immunol 21:597\u2013611","journal-title":"Nat Rev Immunol"},{"key":"975_CR5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","volume":"13","author":"J Anrather","year":"2016","unstructured":"Anrather J, Iadecola C (2016) Inflammation and stroke: an overview. Neurotherapeutics 13:661\u2013670","journal-title":"Neurotherapeutics"},{"key":"975_CR6","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neuint.2017.02.009","volume":"107","author":"A Rayasam","year":"2017","unstructured":"Rayasam A, Hsu M, Hern\u00e1ndez G, Kijak J, Lindstedt A, Gerhart C, Sandor M, Fabry Z (2017) Contrasting roles of immune cells in tissue injury and repair in stroke: the dark and bright side of immunity in the brain. Neurochem Int 107:104\u2013116","journal-title":"Neurochem Int"},{"key":"975_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s11481-014-9560-2","volume":"9","author":"HA Seifert","year":"2014","unstructured":"Seifert HA, Collier LA, Chapman CB, Benkovic SA, Willing AE, Pennypacker KR (2014) Pro-inflammatory interferon gamma signaling is directly associated with stroke induced neurodegeneration. J Neuroimmune Pharmacol 9:679\u2013689","journal-title":"J Neuroimmune Pharmacol"},{"key":"975_CR8","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.105.593046","volume":"113","author":"G Yilmaz","year":"2006","unstructured":"Yilmaz G, Arumugam TV, Stokes KY, Granger DN (2006) Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113:2105\u20132112","journal-title":"Circulation"},{"key":"975_CR9","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","volume":"30","author":"EM Shevach","year":"2009","unstructured":"Shevach EM (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30:636\u2013645","journal-title":"Immunity"},{"key":"975_CR10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1189\/jlb.0606409","volume":"81","author":"N Ralainirina","year":"2007","unstructured":"Ralainirina N, Poli A, Michel T, Poos L, Andr\u00e8s E, Hentges F, Zimmer J (2007) Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol 81:144\u2013153","journal-title":"J Leukoc Biol"},{"key":"975_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","volume":"565","author":"M Ito","year":"2019","unstructured":"Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A (2019) Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 565:246\u2013250","journal-title":"Nature"},{"key":"975_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jneuroim.2008.11.001","volume":"206","author":"J Yan","year":"2009","unstructured":"Yan J, Greer JM, Etherington K, Cadigan GP, Cavanagh H, Henderson RD, O\u2019Sullivan JD, Pandian JD, Read SJ, McCombe PA (2009) Immune activation in the peripheral blood of patients with acute ischemic stroke. J Neuroimmunol 206:112\u2013117","journal-title":"J Neuroimmunol"},{"key":"975_CR13","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.neuroscience.2008.06.014","volume":"158","author":"X Urra","year":"2009","unstructured":"Urra X, Cervera A, Villamor N, Planas AM, Chamorro A (2009) Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience 158:1174\u20131183","journal-title":"Neuroscience"},{"key":"975_CR14","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1093\/brain\/awx111","volume":"140","author":"L Mao","year":"2017","unstructured":"Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen G, Hu X (2017) Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke. Brain 140:1914\u20131931","journal-title":"Brain"},{"key":"975_CR15","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1084\/jem.20021098","volume":"198","author":"K Prass","year":"2003","unstructured":"Prass K, Meisel C, H\u00f6flich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A (2003) Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 198:725\u2013736","journal-title":"J Exp Med"},{"key":"975_CR16","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.4049\/jimmunol.176.11.6523","volume":"176","author":"H Offner","year":"2006","unstructured":"Offner H, Subramanian S, Parker SM, Wang C, Afentoulis ME, Lewis A, Vandenbark AA, Hurn PD (2006) Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol 176:6523\u20136531","journal-title":"J Immunol"},{"key":"975_CR17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12883-020-01648-w","volume":"20","author":"M Santamaria-Cadavid","year":"2020","unstructured":"Santamaria-Cadavid M, Rodriguez-Castro E, Rodriguez-Yanez M, Arias-Rivas S, Lopez-Dequidt I, Perez-Mato M, Rodriguez-Perez M, Lopez-Loureiro I, Hervella P, Campos F, Castillo J, Iglesias-Rey R, Sobrino T (2020) Regulatory T cells participate in the recovery of ischemic stroke patients. BMC Neurol 20:68","journal-title":"BMC Neurol"},{"key":"975_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jneuroim.2011.12.019","volume":"243","author":"J Yan","year":"2012","unstructured":"Yan J, Read SJ, Henderson RD, Hull R, O\u2019Sullivan JD, McCombe PA, Greer JM (2012) Frequency and function of regulatory T cells after ischaemic stroke in humans. J Neuroimmunol 243:89\u201394","journal-title":"J Neuroimmunol"},{"key":"975_CR19","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1055\/s-0037-1599055","volume":"78","author":"X Pang","year":"2017","unstructured":"Pang X, Qian W (2017) Changes in regulatory T-cell levels in acute cerebral ischemia. J Neurol Surg A Cent Eur Neurosurg 78:374\u2013379","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"975_CR20","doi-asserted-by":"publisher","first-page":"577404","DOI":"10.1016\/j.jneuroim.2020.577404","volume":"349","author":"J Zhang","year":"2020","unstructured":"Zhang J, Liu G, Chen D, Wang Z, Chen D, Liu Y, Yu W (2020) The combination of CC chemokine receptor type 5(CCR5) and Treg cells predicts prognosis in patients with ischemic stroke. J Neuroimmunol 349:577404","journal-title":"J Neuroimmunol"},{"key":"975_CR21","doi-asserted-by":"publisher","first-page":"2974605","DOI":"10.1155\/2016\/2974605","volume":"2016","author":"J Ruhnau","year":"2016","unstructured":"Ruhnau J, Schulze J, von Sarnowski B, Heinrich M, Langner S, Potschke C, Wilden A, Kessler C, Broker BM, Vogelgesang A, Dressel A (2016) Reduced numbers and impaired function of regulatory T cells in peripheral blood of ischemic stroke patients. Mediators Inflamm 2016:2974605","journal-title":"Mediators Inflamm"},{"key":"975_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1084\/jem.182.5.1377","volume":"182","author":"TM Foy","year":"1995","unstructured":"Foy TM, Page DM, Waldschmidt TJ, Schoneveld A, Laman JD, Masters SR, Tygrett L, Ledbetter JA, Aruffo A, Claassen E, Xu JC, Flavell RA, Oehen S, Hedrick SM, Noelle RJ (1995) An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med 182:1377\u20131388","journal-title":"J Exp Med"},{"key":"975_CR23","doi-asserted-by":"crossref","unstructured":"Li P, Wang L, Zhou Y, Gan Y, Zhu W, Xia Y, Jiang X, Watkins S, Vazquez A, Thomson AW, Chen J, Yu W, Hu X. 2017. C-C chemokine receptor type 5 (CCR5)-mediated docking of transferred Tregs protects against early blood-brain barrier disruption After Stroke. J Am Heart Assoc 6","DOI":"10.1161\/JAHA.117.006387"},{"key":"975_CR24","doi-asserted-by":"crossref","unstructured":"Lucaciu A, Kuhn H, Trautmann S, Ferreiros N, Steinmetz H, Pfeilschifter J, Brunkhorst R, Pfeilschifter W, Subburayalu J, Vutukuri R. 2020. A sphingosine 1-phosphate gradient is linked to the cerebral recruitment of T helper and regulatory T helper cells during acute ischemic stroke. Int J Mol Sci 21","DOI":"10.3390\/ijms21176242"},{"key":"975_CR25","doi-asserted-by":"publisher","first-page":"855","DOI":"10.7150\/thno.17558","volume":"7","author":"HT Lee","year":"2017","unstructured":"Lee HT, Liu SP, Lin CH, Lee SW, Hsu CY, Sytwu HK, Hsieh CH, Shyu WC (2017) A crucial role of CXCL14 for promoting regulatory T cells activation in stroke. Theranostics 7:855\u2013875","journal-title":"Theranostics"},{"issue":"1527\u201342","key":"975_CR26","first-page":"e8","volume":"54","author":"L Shi","year":"2021","unstructured":"Shi L, Sun Z, Su W, Xu F, Xie D, Zhang Q, Dai X, Iyer K, Hitchens TK, Foley LM, Li S, Stolz DB, Chen K, Ding Y, Thomson AW, Leak RK, Chen J, Hu X (2021) Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 54(1527\u201342):e8","journal-title":"Immunity"},{"key":"975_CR27","doi-asserted-by":"publisher","first-page":"106027","DOI":"10.1016\/j.intimp.2019.106027","volume":"81","author":"S Guo","year":"2020","unstructured":"Guo S, Luo Y (2020) Brain Foxp3(+) regulatory T cells can be expanded by Interleukin-33 in mouse ischemic stroke. Int Immunopharmacol 81:106027","journal-title":"Int Immunopharmacol"},{"key":"975_CR28","doi-asserted-by":"publisher","first-page":"860772","DOI":"10.3389\/fimmu.2022.860772","volume":"13","author":"D Xie","year":"2022","unstructured":"Xie D, Miao W, Xu F, Yuan C, Li S, Wang C, Junagade A, Hu X (2022) IL-33\/ST2 axis protects against traumatic brain injury through enhancing the function of regulatory T cells. Front Immunol 13:860772","journal-title":"Front Immunol"},{"key":"975_CR29","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nm.1927","volume":"15","author":"A Liesz","year":"2009","unstructured":"Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R (2009) Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 15:192\u2013199","journal-title":"Nat Med"},{"key":"975_CR30","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1182\/blood-2012-04-426734","volume":"121","author":"C Kleinschnitz","year":"2013","unstructured":"Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121:679\u2013691","journal-title":"Blood"},{"key":"975_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11011-010-9226-6","volume":"26","author":"X Ren","year":"2011","unstructured":"Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H (2011) CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. Metab Brain Dis 26:87\u201390","journal-title":"Metab Brain Dis"},{"key":"975_CR32","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1161\/STROKEAHA.114.008608","volume":"46","author":"A Liesz","year":"2015","unstructured":"Liesz A, Hu X, Kleinschnitz C, Offner H (2015) Functional role of regulatory lymphocytes in stroke: facts and controversies. Stroke 46:1422\u20131430","journal-title":"Stroke"},{"key":"975_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fncel.2015.00361","volume":"9","author":"J Wang","year":"2015","unstructured":"Wang J, Xie L, Yang C, Ren C, Zhou K, Wang B, Zhang Z, Wang Y, Jin K, Yang GY (2015) Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10. Front Cell Neurosci 9:361","journal-title":"Front Cell Neurosci"},{"key":"975_CR34","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/ana.23815","volume":"74","author":"P Li","year":"2013","unstructured":"Li P, Gan Y, Sun BL, Zhang F, Lu B, Gao Y, Liang W, Thomson AW, Chen J, Hu X (2013) Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol 74:458\u2013471","journal-title":"Ann Neurol"},{"key":"975_CR35","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1161\/STROKEAHA.113.004100","volume":"45","author":"P Li","year":"2014","unstructured":"Li P, Mao L, Liu X, Gan Y, Zheng J, Thomson AW, Gao Y, Chen J, Hu X (2014) Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke. Stroke 45:857\u2013864","journal-title":"Stroke"},{"key":"975_CR36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41582-018-0028-5","volume":"14","author":"X Hu","year":"2018","unstructured":"Hu X, Leak RK, Thomson AW, Yu F, Xia Y, Wechsler LR, Chen J (2018) Promises and limitations of immune cell-based therapies in neurological disorders. Nat Rev Neurol 14:559\u2013568","journal-title":"Nat Rev Neurol"},{"key":"975_CR37","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature06306","volume":"450","author":"LW Collison","year":"2007","unstructured":"Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (2007) The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566\u2013569","journal-title":"Nature"},{"key":"975_CR38","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1073\/pnas.0408197102","volume":"102","author":"ML Chen","year":"2005","unstructured":"Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 102:419\u2013424","journal-title":"Proc Natl Acad Sci U S A"},{"key":"975_CR39","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nm.4068","volume":"22","author":"C Benakis","year":"2016","unstructured":"Benakis C, Brea D, Caballero S, Faraco G, Moore J, Murphy M, Sita G, Racchumi G, Ling L, Pamer EG, Iadecola C, Anrather J (2016) Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells. Nat Med 22:516\u2013523","journal-title":"Nat Med"},{"key":"975_CR40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/eji.201444823","volume":"45","author":"L Xie","year":"2015","unstructured":"Xie L, Choudhury GR, Winters A, Yang SH, Jin K (2015) Cerebral regulatory T cells restrain microglia\/macrophage-mediated inflammatory responses via IL-10. Eur J Immunol 45:180\u2013191","journal-title":"Eur J Immunol"},{"key":"975_CR41","doi-asserted-by":"publisher","first-page":"155","DOI":"10.5607\/en20062","volume":"30","author":"M Kim","year":"2021","unstructured":"Kim M, Kim SD, Kim KI, Jeon EH, Kim MG, Lim YR, Lkhagva-Yondon E, Oh Y, Na K, Chung YC, Jin BK, Song YS, Jeon MS (2021) Dynamics of T lymphocyte between the periphery and the brain from the acute to the chronic phase following ischemic stroke in mice. Exp Neurobiol 30:155\u2013169","journal-title":"Exp Neurobiol"},{"key":"975_CR42","doi-asserted-by":"crossref","unstructured":"Sanjabi S, Oh SA, Li MO. 2017. Regulation of the immune response by TGF-\u03b2: from conception to autoimmunity and infection. Cold Spring Harb Perspect Biol 9","DOI":"10.1101\/cshperspect.a022236"},{"key":"975_CR43","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s10072-018-3250-4","volume":"39","author":"S Dolati","year":"2018","unstructured":"Dolati S, Ahmadi M, Khalili M, Taheraghdam AA, Siahmansouri H, Babaloo Z, Aghebati-Maleki L, Jadidi-Niaragh F, Younesi V, Yousefi M (2018) Peripheral Th17\/Treg imbalance in elderly patients with ischemic stroke. Neurol Sci 39:647\u2013654","journal-title":"Neurol Sci"},{"key":"975_CR44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.2174\/18715273113129990058","volume":"12","author":"M Wang","year":"2013","unstructured":"Wang M, Wang Y, He J, Wei S, Zhang N, Liu F, Liu X, Kang Y, Yao X (2013) Albumin induces neuroprotection against ischemic stroke by altering Toll-like receptor 4 and regulatory T cells in mice. CNS Neurol Disord Drug Targets 12:220\u2013227","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"975_CR45","doi-asserted-by":"publisher","first-page":"683332","DOI":"10.3389\/fimmu.2021.683332","volume":"12","author":"K Liu","year":"2021","unstructured":"Liu K, Huang A, Nie J, Tan J, Xing S, Qu Y, Jiang K (2021) IL-35 regulates the function of immune cells in tumor microenvironment. Front Immunol 12:683332","journal-title":"Front Immunol"},{"key":"975_CR46","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1007\/s11064-018-2560-5","volume":"43","author":"C Xu","year":"2018","unstructured":"Xu C, Zhu H, Shen R, Feng Q, Zhou H, Zhao Z (2018) IL-35 is a protective immunomodulator in brain ischemic injury in mice. Neurochem Res 43:1454\u20131463","journal-title":"Neurochem Res"},{"key":"975_CR47","doi-asserted-by":"crossref","unstructured":"Xiao T, Qu H, Zeng Z, Li C, Wan J. 2022. Interleukin-35 from interleukin-4-stimulated macrophages alleviates oxygen glucose deprivation\/re-oxygenation-induced neuronal cell death via the Wnt\/\u03b2-catenin signaling pathway. Neurotox Res","DOI":"10.1007\/s12640-022-00478-7"},{"key":"975_CR48","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1084\/jem.20030152","volume":"198","author":"W Chen","year":"2003","unstructured":"Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875\u20131886","journal-title":"J Exp Med"},{"key":"975_CR49","doi-asserted-by":"publisher","first-page":"5213","DOI":"10.4049\/jimmunol.172.9.5213","volume":"172","author":"SG Zheng","year":"2004","unstructured":"Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA (2004) Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 172:5213\u20135221","journal-title":"J Immunol"},{"key":"975_CR50","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1161\/STROKEAHA.115.010592","volume":"46","author":"S Bodhankar","year":"2015","unstructured":"Bodhankar S, Chen Y, Lapato A, Dotson AL, Wang J, Vandenbark AA, Saugstad JA, Offner H (2015) PD-L1 monoclonal antibody treats ischemic stroke by controlling central nervous system inflammation. Stroke 46:2926\u20132934","journal-title":"Stroke"},{"key":"975_CR51","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/1742-2094-10-111","volume":"10","author":"S Bodhankar","year":"2013","unstructured":"Bodhankar S, Chen Y, Vandenbark AA, Murphy SJ, Offner H (2013) PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1. J Neuroinflammation 10:111","journal-title":"J Neuroinflammation"},{"key":"975_CR52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.coi.2011.12.009","volume":"24","author":"SL Topalian","year":"2012","unstructured":"Topalian SL, Drake CG, Pardoll DM (2012) Targeting the PD-1\/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 24:207\u2013212","journal-title":"Curr Opin Immunol"},{"key":"975_CR53","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1126\/science.1160062","volume":"322","author":"K Wing","year":"2008","unstructured":"Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271\u2013275","journal-title":"Science"},{"key":"975_CR54","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1126\/science.1202947","volume":"332","author":"OS Qureshi","year":"2011","unstructured":"Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM (2011) Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332:600\u2013603","journal-title":"Science"},{"key":"975_CR55","doi-asserted-by":"publisher","first-page":"e23756","DOI":"10.1002\/jcla.23756","volume":"35","author":"J Ma","year":"2021","unstructured":"Ma J, Shen L, Bao L, Yuan H, Wang Y, Liu H, Wang Q (2021) A novel prognosis prediction model, including cytotoxic T lymphocyte-associated antigen-4, ischemia-modified albumin, lipoprotein-associated phospholipase A2, glial fibrillary acidic protein, and homocysteine, for ischemic stroke in the Chinese hypertensive population. J Clin Lab Anal 35:e23756","journal-title":"J Clin Lab Anal"},{"key":"975_CR56","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.intimp.2018.04.043","volume":"60","author":"MY Noh","year":"2018","unstructured":"Noh MY, Lee WM, Lee SJ, Kim HY, Kim SH, Kim YS (2018) Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients. Int Immunopharmacol 60:104\u2013110","journal-title":"Int Immunopharmacol"},{"key":"975_CR57","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1182\/blood-2006-04-016451","volume":"109","author":"MI Gar\u00edn","year":"2007","unstructured":"Gar\u00edn MI, Chu CC, Golshayan D, Cernuda-Moroll\u00f3n E, Wait R, Lechler RI (2007) Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 109:2058\u20132065","journal-title":"Blood"},{"key":"975_CR58","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1084\/jem.194.5.629","volume":"194","author":"K Nakamura","year":"2001","unstructured":"Nakamura K, Kitani A, Strober W (2001) Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 194:629\u2013644","journal-title":"J Exp Med"},{"key":"975_CR59","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s12975-021-00913-5","volume":"13","author":"YH Cheng","year":"2022","unstructured":"Cheng YH, Jiang YF, Qin C, Shang K, Yuan Y, Wei XJ, Xu Z, Luo X, Wang W, Qu WS (2022) Galectin-1 contributes to vascular remodeling and blood flow recovery after cerebral ischemia in mice. Transl Stroke Res 13:160\u2013170","journal-title":"Transl Stroke Res"},{"key":"975_CR60","doi-asserted-by":"publisher","first-page":"9621","DOI":"10.1038\/srep09621","volume":"5","author":"J Wang","year":"2015","unstructured":"Wang J, Xia J, Zhang F, Shi Y, Wu Y, Pu H, Liou AK, Leak RK, Yu X, Chen L, Chen J (2015) Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury. Sci Rep 5:9621","journal-title":"Sci Rep"},{"key":"975_CR61","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.expneurol.2007.06.024","volume":"207","author":"S Ishibashi","year":"2007","unstructured":"Ishibashi S, Kuroiwa T, Sakaguchi M, Sun L, Kadoya T, Okano H, Mizusawa H (2007) Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Exp Neurol 207:302\u2013313","journal-title":"Exp Neurol"},{"key":"975_CR62","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1007\/s11064-010-0234-z","volume":"35","author":"WS Qu","year":"2010","unstructured":"Qu WS, Wang YH, Wang JP, Tang YX, Zhang Q, Tian DS, Yu ZY, Xie MJ, Wang W (2010) Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia. Neurochem Res 35:1716\u20131724","journal-title":"Neurochem Res"},{"key":"975_CR63","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pneurobio.2016.04.005","volume":"141","author":"Y Wang","year":"2016","unstructured":"Wang Y, Liu G, Hong D, Chen F, Ji X, Cao G (2016) White matter injury in ischemic stroke. Prog Neurobiol 141:45\u201360","journal-title":"Prog Neurobiol"},{"key":"975_CR64","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nn.4528","volume":"20","author":"Y Dombrowski","year":"2017","unstructured":"Dombrowski Y, O\u2019Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC (2017) Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci 20:674\u2013680","journal-title":"Nat Neurosci"},{"key":"975_CR65","doi-asserted-by":"publisher","first-page":"18018","DOI":"10.1073\/pnas.1922089117","volume":"117","author":"GN de la Vega","year":"2020","unstructured":"de la Vega GN, Penalva R, Dittmer M, Naughton M, Falconer J, Moffat J, de la Fuente AG, Hombrebueno JR, Lin Z, Perbal B, Ingram RJ, Evergren E, Fitzgerald DC (2020) Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination. Proc Natl Acad Sci U S A 117:18018\u201318028","journal-title":"Proc Natl Acad Sci U S A"},{"key":"975_CR66","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1083\/jcb.200308101","volume":"164","author":"J Hsieh","year":"2004","unstructured":"Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage FH (2004) IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol 164:111\u2013122","journal-title":"J Cell Biol"},{"key":"975_CR67","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.bbi.2010.01.005","volume":"24","author":"I Glezer","year":"2010","unstructured":"Glezer I, Rivest S (2010) Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites. Brain Behav Immun 24:695\u2013704","journal-title":"Brain Behav Immun"},{"key":"975_CR68","doi-asserted-by":"publisher","first-page":"S134","DOI":"10.1177\/0271678X20963405","volume":"40","author":"X Hu","year":"2020","unstructured":"Hu X (2020) Microglia\/macrophage polarization: fantasy or evidence of functional diversity? J Cereb Blood Flow Metab 40:S134\u2013S136","journal-title":"J Cereb Blood Flow Metab"},{"key":"975_CR69","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/cns.13620","volume":"27","author":"J Lyu","year":"2021","unstructured":"Lyu J, Xie D, Bhatia TN, Leak RK, Hu X, Jiang X (2021) Microglial\/macrophage polarization and function in brain injury and repair after stroke. CNS Neurosci Ther 27:515\u2013527","journal-title":"CNS Neurosci Ther"},{"key":"975_CR70","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1189\/jlb.0507296","volume":"82","author":"AD Reynolds","year":"2007","unstructured":"Reynolds AD, Banerjee R, Liu J, Gendelman HE, Mosley RL (2007) Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson\u2019s disease. J Leukoc Biol 82:1083\u20131094","journal-title":"J Leukoc Biol"},{"key":"975_CR71","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.4049\/jimmunol.0803982","volume":"182","author":"AD Reynolds","year":"2009","unstructured":"Reynolds AD, Stone DK, Mosley RL, Gendelman HE (2009) Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets. J Immunol 182:4137\u20134149","journal-title":"J Immunol"},{"key":"975_CR72","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/brain\/awr074","volume":"134","author":"DR Beers","year":"2011","unstructured":"Beers DR, Henkel JS, Zhao W, Wang J, Huang A, Wen S, Liao B, Appel SH (2011) Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain 134:1293\u20131314","journal-title":"Brain"},{"key":"975_CR73","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.nbd.2012.07.008","volume":"48","author":"W Zhao","year":"2012","unstructured":"Zhao W, Beers DR, Liao B, Henkel JS, Appel SH (2012) Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis 48:418\u2013428","journal-title":"Neurobiol Dis"},{"key":"975_CR74","doi-asserted-by":"crossref","unstructured":"Moorman HR, Poschel D, Klement JD, Lu C, Redd PS, Liu K. 2020. Osteopontin: a key regulator of tumor progression and immunomodulation. Cancers (Basel) 12","DOI":"10.3390\/cancers12113379"},{"key":"975_CR75","doi-asserted-by":"publisher","first-page":"577546","DOI":"10.1016\/j.jneuroim.2021.577546","volume":"354","author":"X He","year":"2021","unstructured":"He X, Lin S, Yang L, Tan P, Ma P, Qiu P, Zheng C, Zhang X, Kang W, Lin W (2021) Programmed death protein 1 is essential for maintaining the anti-inflammatory function of infiltrating regulatory T cells in a murine spinal cord injury model. J Neuroimmunol 354:577546","journal-title":"J Neuroimmunol"},{"key":"975_CR76","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1146\/annurev.physiol.63.1.795","volume":"63","author":"A Araque","year":"2001","unstructured":"Araque A, Carmignoto G, Haydon PG (2001) Dynamic signaling between astrocytes and neurons. Annu Rev Physiol 63:795\u2013813","journal-title":"Annu Rev Physiol"},{"key":"975_CR77","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/35058528","volume":"2","author":"PG Haydon","year":"2001","unstructured":"Haydon PG (2001) GLIA: listening and talking to the synapse. Nat Rev Neurosci 2:185\u2013193","journal-title":"Nat Rev Neurosci"},{"key":"975_CR78","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1523\/JNEUROSCI.3547-03.2004","volume":"24","author":"JR Faulkner","year":"2004","unstructured":"Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV (2004) Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 24:2143\u20132155","journal-title":"J Neurosci"},{"key":"975_CR79","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/sj.jcbfm.9600546","volume":"28","author":"L Li","year":"2008","unstructured":"Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Stahlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M (2008) Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 28:468\u2013481","journal-title":"J Cereb Blood Flow Metab"},{"key":"975_CR80","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1002\/glia.20721","volume":"56","author":"IB Wanner","year":"2008","unstructured":"Wanner IB, Deik A, Torres M, Rosendahl A, Neary JT, Lemmon VP, Bixby JL (2008) A new in vitro model of the glial scar inhibits axon growth. Glia 56:1691\u20131709","journal-title":"Glia"},{"key":"975_CR81","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainres.2014.08.064","volume":"1619","author":"Y Ohtake","year":"2015","unstructured":"Ohtake Y, Li S (2015) Molecular mechanisms of scar-sourced axon growth inhibitors. Brain Res 1619:22\u201335","journal-title":"Brain Res"},{"key":"975_CR82","doi-asserted-by":"crossref","unstructured":"Zador Z, Stiver S, Wang V, Manley GT. 2009. Role of aquaporin-4 in cerebral edema and stroke. Handb Exp Pharmacol: 159\u201370","DOI":"10.1007\/978-3-540-79885-9_7"},{"key":"975_CR83","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1084\/jem.20041918","volume":"202","author":"R Brambilla","year":"2005","unstructured":"Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR (2005) Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 202:145\u2013156","journal-title":"J Exp Med"},{"key":"975_CR84","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1073\/pnas.0808698106","volume":"106","author":"AT Argaw","year":"2009","unstructured":"Argaw AT, Gurfein BT, Zhang Y, Zameer A, John GR (2009) VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A 106:1977\u20131982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"975_CR85","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46:957\u2013967","journal-title":"Immunity"},{"key":"975_CR86","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.immuni.2012.09.023","volume":"38","author":"DM Zaiss","year":"2013","unstructured":"Zaiss DM, van Loosdregt J, Gorlani A, Bekker CP, Gr\u00f6ne A, Sibilia M, van Bergen en Henegouwen PM, Roovers RC, Coffer PJ, Sijts AJ. (2013) Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity 38:275\u2013284","journal-title":"Immunity"},{"key":"975_CR87","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","volume":"162","author":"N Arpaia","year":"2015","unstructured":"Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting PM, Rudensky AY (2015) A distinct function of regulatory T cells in tissue protection. Cell 162:1078\u20131089","journal-title":"Cell"},{"key":"975_CR88","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1093\/brain\/aww113","volume":"139","author":"L Mayo","year":"2016","unstructured":"Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL (2016) IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain 139:1939\u20131957","journal-title":"Brain"},{"key":"975_CR89","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jneuroim.2015.06.013","volume":"286","author":"A Chan","year":"2015","unstructured":"Chan A, Yan J, Csurhes P, Greer J, McCombe P (2015) Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. J Neuroimmunol 286:42\u201347","journal-title":"J Neuroimmunol"},{"key":"975_CR90","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41577-019-0232-6","volume":"20","author":"C Raffin","year":"2020","unstructured":"Raffin C, Vo LT, Bluestone JA (2020) T(reg) cell-based therapies: challenges and perspectives. Nat Rev Immunol 20:158\u2013172","journal-title":"Nat Rev Immunol"},{"key":"975_CR91","doi-asserted-by":"crossref","unstructured":"Yin J, Liao SX, He Y, Wang S, Xia GH, Liu FT, Zhu JJ, You C, Chen Q, Zhou L, Pan SY, Zhou HW. 2015. Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack. J Am Heart Assoc 4","DOI":"10.1161\/JAHA.115.002699"},{"key":"975_CR92","doi-asserted-by":"publisher","first-page":"e0171521","DOI":"10.1371\/journal.pone.0171521","volume":"12","author":"K Yamashiro","year":"2017","unstructured":"Yamashiro K, Tanaka R, Urabe T, Ueno Y, Yamashiro Y, Nomoto K, Takahashi T, Tsuji H, Asahara T, Hattori N (2017) Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS ONE 12:e0171521","journal-title":"PLoS ONE"},{"key":"975_CR93","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12975-020-00863-4","volume":"12","author":"BW Haak","year":"2021","unstructured":"Haak BW, Westendorp WF, van Engelen TSR, Brands X, Brouwer MC, Vermeij JD, Hugenholtz F, Verhoeven A, Derks RJ, Giera M, Nederkoorn PJ, de Vos WM, van de Beek D, Wiersinga WJ (2021) Disruptions of anaerobic gut bacteria are associated with stroke and post-stroke infection: a prospective case-control study. Transl Stroke Res 12:581\u2013592","journal-title":"Transl Stroke Res"},{"key":"975_CR94","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbi.2016.04.003","volume":"57","author":"A Houlden","year":"2016","unstructured":"Houlden A, Goldrick M, Brough D, Vizi ES, Lenart N, Martinecz B, Roberts IS, Denes A (2016) Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production. Brain Behav Immun 57:10\u201320","journal-title":"Brain Behav Immun"},{"key":"975_CR95","doi-asserted-by":"publisher","first-page":"7428","DOI":"10.1523\/JNEUROSCI.1114-16.2016","volume":"36","author":"V Singh","year":"2016","unstructured":"Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, Dichgans M, Liesz A (2016) Microbiota dysbiosis controls the neuroinflammatory response after stroke. J Neurosci 36:7428\u20137440","journal-title":"J Neurosci"},{"key":"975_CR96","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bbi.2017.03.011","volume":"66","author":"R Sadler","year":"2017","unstructured":"Sadler R, Singh V, Benakis C, Garzetti D, Brea D, Stecher B, Anrather J, Liesz A (2017) Microbiota differences between commercial breeders impacts the post-stroke immune response. Brain Behav Immun 66:23\u201330","journal-title":"Brain Behav Immun"},{"key":"975_CR97","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1161\/STROKEAHA.120.029262","volume":"51","author":"C Benakis","year":"2020","unstructured":"Benakis C, Poon C, Lane D, Brea D, Sita G, Moore J, Murphy M, Racchumi G, Iadecola C, Anrather J (2020) Distinct commensal bacterial signature in the gut is associated with acute and long-term protection from ischemic stroke. Stroke 51:1844\u20131854","journal-title":"Stroke"},{"key":"975_CR98","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jim.2018.08.005","volume":"463","author":"AA Sadighi Akha","year":"2018","unstructured":"Sadighi Akha AA (2018) Aging and the immune system: an overview. J Immunol Methods 463:21\u201326","journal-title":"J Immunol Methods"},{"key":"975_CR99","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41380-021-01361-1","volume":"27","author":"CE Finger","year":"2022","unstructured":"Finger CE, Moreno-Gonzalez I, Gutierrez A, Moruno-Manchon JF, McCullough LD (2022) Age-related immune alterations and cerebrovascular inflammation. Mol Psychiatry 27:803\u2013818","journal-title":"Mol Psychiatry"},{"key":"975_CR100","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.coi.2012.04.005","volume":"24","author":"J Raynor","year":"2012","unstructured":"Raynor J, Lages CS, Shehata H, Hildeman DA, Chougnet CA (2012) Homeostasis and function of regulatory T cells in aging. Curr Opin Immunol 24:482\u2013487","journal-title":"Curr Opin Immunol"},{"key":"975_CR101","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.mad.2009.06.003","volume":"130","author":"KA Hwang","year":"2009","unstructured":"Hwang KA, Kim HR, Kang I (2009) Aging and human CD4(+) regulatory T cells. Mech Ageing Dev 130:509\u2013517","journal-title":"Mech Ageing Dev"},{"key":"975_CR102","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jneuroim.2007.05.011","volume":"188","author":"D Rosenkranz","year":"2007","unstructured":"Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L (2007) Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol 188:117\u2013127","journal-title":"J Neuroimmunol"},{"key":"975_CR103","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/acel.12191","volume":"13","author":"SK Garg","year":"2014","unstructured":"Garg SK, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R (2014) Aging is associated with increased regulatory T-cell function. Aging Cell 13:441\u2013448","journal-title":"Aging Cell"},{"key":"975_CR104","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1189\/jlb.0506364","volume":"81","author":"L Zhao","year":"2007","unstructured":"Zhao L, Sun L, Wang H, Ma H, Liu G, Zhao Y (2007) Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb\/c mice. J Leukoc Biol 81:1386\u20131394","journal-title":"J Leukoc Biol"},{"key":"975_CR105","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1002\/eji.201343532","volume":"43","author":"M Carpentier","year":"2013","unstructured":"Carpentier M, Chappert P, Kuhn C, Lalfer M, Flament H, Burlen-Defranoux O, Lantz O, Bandeira A, Malissen B, Davoust J, Gross DA (2013) Extrathymic induction of Foxp3(+) regulatory T cells declines with age in a T-cell intrinsic manner. Eur J Immunol 43:2598\u20132604","journal-title":"Eur J Immunol"},{"key":"975_CR106","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4049\/jimmunol.1001505","volume":"186","author":"CA Chougnet","year":"2011","unstructured":"Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA (2011) A major role for Bim in regulatory T cell homeostasis. J Immunol 186:156\u2013163","journal-title":"J Immunol"},{"key":"975_CR107","doi-asserted-by":"publisher","first-page":"616949","DOI":"10.3389\/fimmu.2020.616949","volume":"11","author":"L Rocamora-Reverte","year":"2020","unstructured":"Rocamora-Reverte L, Melzer FL, Wurzner R, Weinberger B (2020) The complex role of regulatory T cells in immunity and aging. Front Immunol 11:616949","journal-title":"Front Immunol"},{"key":"975_CR108","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.exger.2014.11.005","volume":"60","author":"KS van der Geest","year":"2014","unstructured":"van der Geest KS, Abdulahad WH, Tete SM, Lorencetti PG, Horst G, Bos NA, Kroesen BJ, Brouwer E, Boots AM (2014) Aging disturbs the balance between effector and regulatory CD4+ T cells. Exp Gerontol 60:190\u2013196","journal-title":"Exp Gerontol"},{"key":"975_CR109","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.4049\/jimmunol.176.11.6586","volume":"176","author":"T Nishioka","year":"2006","unstructured":"Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S (2006) CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J Immunol 176:6586\u20136593","journal-title":"J Immunol"},{"key":"975_CR110","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000355303","volume":"60","author":"A Jagger","year":"2014","unstructured":"Jagger A, Shimojima Y, Goronzy JJ, Weyand CM (2014) Regulatory T cells and the immune aging process: a mini-review. Gerontology 60:130\u2013137","journal-title":"Gerontology"},{"key":"975_CR111","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.immuni.2016.01.009","volume":"44","author":"W Kuswanto","year":"2016","unstructured":"Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D (2016) Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells. Immunity 44:355\u2013367","journal-title":"Immunity"},{"key":"975_CR112","first-page":"567","volume":"58","author":"G Afshan","year":"2012","unstructured":"Afshan G, Afzal N, Qureshi S (2012) CD4+CD25(hi) regulatory T cells in healthy males and females mediate gender difference in the prevalence of autoimmune diseases. Clin Lab 58:567\u2013571","journal-title":"Clin Lab"},{"key":"975_CR113","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1161\/STROKEAHA.121.037537","volume":"53","author":"L Beckmann","year":"2022","unstructured":"Beckmann L, Obst S, Labusek N, Abberger H, Koster C, Klein-Hitpass L, Schumann S, Kleinschnitz C, Hermann DM, Felderhoff-Muser U, Bendix I, Hansen W, Herz J (2022) Regulatory T cells contribute to sexual dimorphism in neonatal hypoxic-ischemic brain injury. Stroke 53:381\u2013390","journal-title":"Stroke"},{"key":"975_CR114","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bbi.2020.02.001","volume":"87","author":"H Ahnstedt","year":"2020","unstructured":"Ahnstedt H, Patrizz A, Chauhan A, Roy-O\u2019Reilly M, Furr JW, Spychala MS, D\u2019Aigle J, Blixt FW, Zhu L, Bravo Alegria J, McCullough LD (2020) Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice. Brain Behav Immun 87:556\u2013567","journal-title":"Brain Behav Immun"},{"key":"975_CR115","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.4049\/jimmunol.175.9.5591","volume":"175","author":"J Reddy","year":"2005","unstructured":"Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK (2005) Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol 175:5591\u20135595","journal-title":"J Immunol"},{"key":"975_CR116","doi-asserted-by":"crossref","unstructured":"Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Jr., Newcomb DC. 2022. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest 132","DOI":"10.1172\/JCI153397"},{"key":"975_CR117","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10238-011-0172-3","volume":"12","author":"C Aristimuno","year":"2012","unstructured":"Aristimuno C, Teijeiro R, Valor L, Alonso B, Tejera-Alhambra M, de Andres C, Minarro DO, Lopez-Lazareno N, Faure F, Sanchez-Ramon S (2012) Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis. Clin Exp Med 12:247\u2013255","journal-title":"Clin Exp Med"},{"key":"975_CR118","doi-asserted-by":"publisher","first-page":"17166","DOI":"10.1073\/pnas.2002266117","volume":"117","author":"WA Goodman","year":"2020","unstructured":"Goodman WA, Bedoyan SM, Havran HL, Richardson B, Cameron MJ, Pizarro TT (2020) Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine. Proc Natl Acad Sci U S A 117:17166\u201317176","journal-title":"Proc Natl Acad Sci U S A"},{"key":"975_CR119","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1097\/BOR.0b013e328277ef2a","volume":"19","author":"AB Pernis","year":"2007","unstructured":"Pernis AB (2007) Estrogen and CD4+ T cells. Curr Opin Rheumatol 19:414\u2013420","journal-title":"Curr Opin Rheumatol"},{"key":"975_CR120","doi-asserted-by":"publisher","first-page":"684657","DOI":"10.3389\/fimmu.2021.684657","volume":"12","author":"W Tian","year":"2021","unstructured":"Tian W, Jiang SY, Jiang X, Tamosiuniene R, Kim D, Guan T, Arsalane S, Pasupneti S, Voelkel NF, Tang Q, Nicolls MR (2021) The role of regulatory T cells in pulmonary arterial hypertension. Front Immunol 12:684657","journal-title":"Front Immunol"},{"key":"975_CR121","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1182\/blood-2004-07-2819","volume":"105","author":"P Gourdy","year":"2005","unstructured":"Gourdy P, Araujo LM, Zhu R, Garmy-Susini B, Diem S, Laurell H, Leite-de-Moraes M, Dy M, Arnal JF, Bayard F, Herbelin A (2005) Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells. Blood 105:2415\u20132420","journal-title":"Blood"},{"key":"975_CR122","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.it.2015.10.003","volume":"36","author":"N Arenas-Ramirez","year":"2015","unstructured":"Arenas-Ramirez N, Woytschak J, Boyman O (2015) Interleukin-2: biology, design and application. Trends Immunol 36:763\u2013777","journal-title":"Trends Immunol"},{"key":"975_CR123","doi-asserted-by":"crossref","unstructured":"Hernandez R, Poder J, LaPorte KM, Malek TR. 2022. Engineering IL-2 for immunotherapy of autoimmunity and cancer. Nat Rev Immunol In press","DOI":"10.1038\/s41577-022-00680-w"},{"key":"975_CR124","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41577-019-0232-6","volume":"20","author":"C Raffin","year":"2020","unstructured":"Raffin C, Vo LT, Bluestone JA (2020) Treg cell-based therapies: challenges and perspectives. Nat Rev Immunol 20:158\u2013172","journal-title":"Nat Rev Immunol"},{"key":"975_CR125","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41576-021-00329-9","volume":"22","author":"GI Ellis","year":"2021","unstructured":"Ellis GI, Sheppard NC, Riley JL (2021) Genetic engineering of T cells for immunotherapy. Nat Rev Genet 22:427\u2013447","journal-title":"Nat Rev Genet"},{"key":"975_CR126","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.omtm.2018.01.006","volume":"8","author":"H Fraser","year":"2018","unstructured":"Fraser H, Safinia N, Grageda N, Thirkell S, Lowe K, Fry LJ, Scotta C, Hope A, Fisher C, Hilton R, Game D, Harden P, Bushell A, Wood K, Lechler RI, Lombardi G (2018) A rapamycin-based GMP-compatible process for the isolation and expansion of regulatory T cells for clinical trials. Mol Ther Methods Clin Dev 8:198\u2013209","journal-title":"Mol Ther Methods Clin Dev"},{"key":"975_CR127","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1172\/JCI82771","volume":"126","author":"KG MacDonald","year":"2016","unstructured":"MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, Broady R, Levings MK (2016) Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest 126:1413\u20131424","journal-title":"J Clin Invest"},{"key":"975_CR128","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/ajt.14185","volume":"17","author":"DA Boardman","year":"2017","unstructured":"Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G (2017) Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection. Am J Transplant 17:931\u2013943","journal-title":"Am J Transplant"},{"key":"975_CR129","doi-asserted-by":"publisher","first-page":"102289","DOI":"10.1016\/j.jaut.2019.05.017","volume":"103","author":"M Tenspolde","year":"2019","unstructured":"Tenspolde M, Zimmermann K, Weber LC, Hapke M, Lieber M, Dywicki J, Frenzel A, Hust M, Galla M, Buitrago-Molina LE, Manns MP, Jaeckel E, Hardtke-Wolenski M (2019) Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes. J Autoimmun 103:102289","journal-title":"J Autoimmun"},{"key":"975_CR130","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1517\/14712598.2015.1046430","volume":"15","author":"M Chmielewski","year":"2015","unstructured":"Chmielewski M, Abken H (2015) TRUCKs: the fourth generation of CARs. Expert Opin Biol Ther 15:1145\u20131154","journal-title":"Expert Opin Biol Ther"},{"key":"975_CR131","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1111\/j.1600-6143.2012.04065.x","volume":"12","author":"J Hester","year":"2012","unstructured":"Hester J, Schiopu A, Nadig SN, Wood KJ (2012) Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 12:2008\u20132016","journal-title":"Am J Transplant"},{"key":"975_CR132","doi-asserted-by":"crossref","unstructured":"Wagner JC, Ronin E, Ho P, Peng Y, Tang Q. 2022. Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival. Am J Transplant In press","DOI":"10.1111\/ajt.17063"},{"key":"975_CR133","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1111\/ajt.15306","volume":"19","author":"K Ratnasothy","year":"2019","unstructured":"Ratnasothy K, Jacob J, Tung S, Boardman D, Lechler RI, Sanchez-Fueyo A, Martinez-Llordella M, Lombardi G (2019) IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival. Am J Transplant 19:2092\u20132100","journal-title":"Am J Transplant"},{"key":"975_CR134","doi-asserted-by":"publisher","first-page":"10168","DOI":"10.1523\/JNEUROSCI.3411-17.2018","volume":"38","author":"H Zhang","year":"2018","unstructured":"Zhang H, Xia Y, Ye Q, Yu F, Zhu W, Li P, Wei Z, Yang Y, Shi Y, Thomson AW, Chen J, Hu X (2018) In vivo expansion of regulatory T cells with IL-2\/IL-2 antibody complex protects against transient ischemic stroke. J Neurosci 38:10168\u201310179","journal-title":"J Neurosci"},{"key":"975_CR135","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41590-022-01208-z","volume":"23","author":"L Yshii","year":"2022","unstructured":"Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, Verhaert J, Tareen SHK, Roca CP, Singh K, Whyte CE, Kerstens A, Callaerts-Vegh Z, Poovathingal S, Prezzemolo T, Wierda K, Dashwood A, Xie J, Van Wonterghem E, Creemers E, Aloulou M, Gsell W, Abiega O, Munck S, Vandenbroucke RE, Bronckaers A, Lemmens R, De Strooper B, Van Den Bosch L, Himmelreich U, Fitzsimons CP, Holt MG, Liston A (2022) Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol 23:878\u2013891","journal-title":"Nat Immunol"},{"key":"975_CR136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.10.017","volume":"95","author":"LB Peterson","year":"2018","unstructured":"Peterson LB, Bell CJM, Howlett SK, Pekalski ML, Brady K, Hinton H, Sauter D, Todd JA, Umana P, Ast O, Waldhauer I, Freimoser-Grundschober A, Moessner E, Klein C, Hosse RJ, Wicker LS (2018) A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease. J Autoimmun 95:1\u201314","journal-title":"J Autoimmun"},{"key":"975_CR137","doi-asserted-by":"crossref","unstructured":"Khoryati L, Pham MN, Sherve M, Kumari S, Cook K, Pearson J, Bogdani M, Campbell DJ, Gavin MA. 2020. An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice. Sci Immunol 5","DOI":"10.1126\/sciimmunol.aba5264"},{"key":"975_CR138","doi-asserted-by":"crossref","unstructured":"Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S, Arumugam TV, Magnus T, Huber S, Gelderblom M, Drummond GR, Sobey CG, Kim HA. 2018. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke. JCI Insight 3","DOI":"10.1172\/jci.insight.121560"},{"key":"975_CR139","doi-asserted-by":"publisher","first-page":"576970","DOI":"10.1016\/j.jneuroim.2019.576970","volume":"333","author":"W Xiao","year":"2019","unstructured":"Xiao W, Guo S, Chen L, Luo Y (2019) The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke. J Neuroimmunol 333:576970","journal-title":"J Neuroimmunol"},{"key":"975_CR140","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1161\/STROKEAHA.114.007756","volume":"46","author":"SY Na","year":"2015","unstructured":"Na SY, Mracsko E, Liesz A, Hunig T, Veltkamp R (2015) Amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice. Stroke 46:212\u2013220","journal-title":"Stroke"},{"key":"975_CR141","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/jcbfm.2014.175","volume":"35","author":"MK Schuhmann","year":"2015","unstructured":"Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C (2015) CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35:6\u201310","journal-title":"J Cereb Blood Flow Metab"},{"key":"975_CR142","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/cns.13611","volume":"27","author":"H Wang","year":"2021","unstructured":"Wang H, Wang Z, Wu Q, Yuan Y, Cao W, Zhang X (2021) Regulatory T cells in ischemic stroke. CNS Neurosci Ther 27:643\u2013651","journal-title":"CNS Neurosci Ther"},{"key":"975_CR143","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nm.3432","volume":"20","author":"N Komatsu","year":"2014","unstructured":"Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H (2014) Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med 20:62\u201368","journal-title":"Nat Med"},{"key":"975_CR144","doi-asserted-by":"publisher","first-page":"813045","DOI":"10.1155\/2014\/813045","volume":"2014","author":"Y Hu","year":"2014","unstructured":"Hu Y, Zheng Y, Wu Y, Ni B, Shi S (2014) Imbalance between IL-17A-producing cells and regulatory T cells during ischemic stroke. Mediators Inflamm 2014:813045","journal-title":"Mediators Inflamm"},{"key":"975_CR145","first-page":"1015","volume":"6","author":"Q Li","year":"2013","unstructured":"Li Q, Wang Y, Yu F, Wang YM, Zhang C, Hu C, Wu Z, Xu X, Hu S (2013) Peripheral Th17\/Treg imbalance in patients with atherosclerotic cerebral infarction. Int J Clin Exp Pathol 6:1015\u20131027","journal-title":"Int J Clin Exp Pathol"},{"key":"975_CR146","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s12017-021-08656-0","volume":"23","author":"MC Borlongan","year":"2021","unstructured":"Borlongan MC, Kingsbury C, Salazar FE, Toledo ARL, Monroy GR, Sadanandan N, Cozene B, Gonzales-Portillo B, Saft M, Wang ZJ, Moscatello A, Lee JY (2021) IL-2\/IL-2R antibody complex enhances Treg-induced neuroprotection by dampening TNF-alpha inflammation in an in vitro stroke model. Neuromolecular Med 23:540\u2013548","journal-title":"Neuromolecular Med"},{"key":"975_CR147","doi-asserted-by":"publisher","first-page":"113233","DOI":"10.1016\/j.expneurol.2020.113233","volume":"328","author":"X Liu","year":"2020","unstructured":"Liu X, Hu R, Pei L, Si P, Wang C, Tian X, Wang X, Liu H, Wang B, Xia Z, Xu Y, Song B (2020) Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke. Exp Neurol 328:113233","journal-title":"Exp Neurol"},{"key":"975_CR148","doi-asserted-by":"publisher","first-page":"6009","DOI":"10.4049\/jimmunol.1303492","volume":"192","author":"L Xie","year":"2014","unstructured":"Xie L, Sun F, Wang J, Mao X, Xie L, Yang SH, Su DM, Simpkins JW, Greenberg DA, Jin K (2014) mTOR signaling inhibition modulates macrophage\/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia. J Immunol 192:6009\u20136019","journal-title":"J Immunol"},{"key":"975_CR149","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12974-021-02083-5","volume":"18","author":"K Malone","year":"2021","unstructured":"Malone K, Diaz Diaz AC, Shearer JA, Moore AC, Waeber C (2021) The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia. J Neuroinflammation 18:37","journal-title":"J Neuroinflammation"},{"key":"975_CR150","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.04.014","volume":"25","author":"H Yang","year":"2016","unstructured":"Yang H, Zhang A, Zhang Y, Ma S, Wang C (2016) Resveratrol pretreatment protected against cerebral ischemia\/reperfusion injury in rats via expansion of T regulatory cells. J Stroke Cerebrovasc Dis 25:1914\u20131921","journal-title":"J Stroke Cerebrovasc Dis"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-022-00975-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-022-00975-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-022-00975-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T12:03:28Z","timestamp":1687176208000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-022-00975-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":150,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["975"],"URL":"https:\/\/doi.org\/10.1007\/s00281-022-00975-z","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]},"assertion":[{"value":"1 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}