{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:09:21Z","timestamp":1792116561382,"version":"4.4.0"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K15187"],"award-info":[{"award-number":["JP18K15187"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H050430"],"award-info":[{"award-number":["JP21H050430"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004206","name":"Osaka University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004206","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules can be classified into two groups based on their functions: those that exhibit bactericidal activity through chemical reactions, such as antimicrobial peptides, and those that physically hinder bacterial invasion, like mucins, which lack bactericidal properties. In the small intestine, where Paneth cells specialize in producing antimicrobial peptides, the chemical barrier molecules primarily inhibit bacterial growth. In contrast, in the large intestine, where Paneth cells are absent, allowing bacterial growth, the primary defense mechanism is the physical barrier, mainly composed of mucus, which controls bacterial movement and prevents their invasion of intestinal tissues. The expression of these barrier molecules is regulated by metabolites produced by bacteria in the intestinal lumen and cytokines produced by immune cells in the lamina propria. This regulation establishes a defense mechanism that adapts to changes in the intestinal environment, such as alterations in gut microbial composition and the presence of pathogenic bacterial infections. Consequently, when the integrity of the gut mucosal barrier is compromised, commensal bacteria and pathogenic microorganisms from outside the body can invade intestinal tissues, leading to conditions such as intestinal inflammation, as observed in cases of inflammatory bowel disease.<\/jats:p>","DOI":"10.1007\/s00281-024-01026-5","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T05:42:49Z","timestamp":1732599769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation"],"prefix":"10.1007","volume":"47","author":[{"given":"Ryu","family":"Okumura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-6332","authenticated-orcid":false,"given":"Kiyoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"1026_CR1","doi-asserted-by":"publisher","first-page":"11200","DOI":"10.1016\/S0021-9258(18)60449-1","volume":"264","author":"CG Wilde","year":"1989","unstructured":"Wilde CG, Griffith JE, Marra MN, Snable JL, Scott RW (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem 264:11200\u201311203","journal-title":"J Biol Chem"},{"key":"1026_CR2","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1172\/JCI112121","volume":"76","author":"ME Selsted","year":"1985","unstructured":"Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI (1985) Primary structures of three human neutrophil defensins. J Clin Invest 76:1436\u20131439. https:\/\/doi.org\/10.1172\/JCI112121","journal-title":"J Clin Invest"},{"key":"1026_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrmicro1098","volume":"3","author":"KA Brogden","year":"2005","unstructured":"Brogden KA (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 3:238\u2013250. https:\/\/doi.org\/10.1038\/nrmicro1098","journal-title":"Nat Rev Microbiol"},{"key":"1026_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1126\/science.286.5437.113","volume":"286","author":"CL Wilson","year":"1999","unstructured":"Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC (1999) Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286:113\u2013117","journal-title":"Science"},{"key":"1026_CR5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/ni1206","volume":"6","author":"ME Selsted","year":"2005","unstructured":"Selsted ME, Ouellette AJ (2005) Mammalian defensins in the antimicrobial immune response. Nat Immunol 6:551\u2013557. https:\/\/doi.org\/10.1038\/ni1206","journal-title":"Nat Immunol"},{"key":"1026_CR6","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.4049\/jimmunol.174.8.4901","volume":"174","author":"M Iimura","year":"2005","unstructured":"Iimura M, Gallo RL, Hase K, Miyamoto Y, Eckmann L, Kagnoff MF (2005) Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J Immunol 174:4901\u20134907","journal-title":"J Immunol"},{"issue":"1288\u20131302","key":"1026_CR7","doi-asserted-by":"publisher","first-page":"e1216","DOI":"10.1053\/j.gastro.2021.12.272","volume":"162","author":"W Liang","year":"2022","unstructured":"Liang W, Enee E, Andre-Vallee C, Falcone M, Sun J, Diana J (2022) Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota Against Pancreatic Autoimmunity. Gastroenterology 162(1288\u20131302):e1216. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.272","journal-title":"Gastroenterology"},{"key":"1026_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11274-023-03545-z","volume":"39","author":"H Memariani","year":"2023","unstructured":"Memariani H, Memariani M (2023) Antibiofilm properties of cathelicidin LL-37: an in-depth review. World J Microbiol Biotechnol 39:99. https:\/\/doi.org\/10.1007\/s11274-023-03545-z","journal-title":"World J Microbiol Biotechnol"},{"key":"1026_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/intimm\/dxq471","volume":"23","author":"K Suzuki","year":"2011","unstructured":"Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I (2011) Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells. Int Immunol 23:185\u2013193. https:\/\/doi.org\/10.1093\/intimm\/dxq471","journal-title":"Int Immunol"},{"key":"1026_CR10","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.4049\/jimmunol.1303062","volume":"192","author":"J Koziel","year":"2014","unstructured":"Koziel J, Bryzek D, Sroka A, Maresz K, Glowczyk I, Bielecka E, Kantyka T, Pyrc K, Svoboda P, Pohl J, Potempa J (2014) Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis. J Immunol 192:5363\u20135372. https:\/\/doi.org\/10.4049\/jimmunol.1303062","journal-title":"J Immunol"},{"key":"1026_CR11","doi-asserted-by":"publisher","first-page":"7722","DOI":"10.1073\/pnas.0909449107","volume":"107","author":"RE Lehotzky","year":"2010","unstructured":"Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV (2010) Molecular basis for peptidoglycan recognition by a bactericidal lectin. Proc Natl Acad Sci U S A 107:7722\u20137727. https:\/\/doi.org\/10.1073\/pnas.0909449107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR12","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1126\/science.1127119","volume":"313","author":"HL Cash","year":"2006","unstructured":"Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313:1126\u20131130. https:\/\/doi.org\/10.1126\/science.1127119","journal-title":"Science"},{"key":"1026_CR13","doi-asserted-by":"publisher","first-page":"34844","DOI":"10.1074\/jbc.M112.399998","volume":"287","author":"T Miki","year":"2012","unstructured":"Miki T, Holst O, Hardt WD (2012) The bactericidal activity of the C-type lectin RegIIIbeta against Gram-negative bacteria involves binding to lipid A. J Biol Chem 287:34844\u201334855. https:\/\/doi.org\/10.1074\/jbc.M112.399998","journal-title":"J Biol Chem"},{"key":"1026_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature12729nature12729[pii]","volume":"505","author":"S Mukherjee","year":"2014","unstructured":"Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV (2014) Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505:103\u2013107. https:\/\/doi.org\/10.1038\/nature12729nature12729[pii]","journal-title":"Nature"},{"key":"1026_CR15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1209791","volume":"334","author":"S Vaishnava","year":"2011","unstructured":"Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334:255\u2013258. https:\/\/doi.org\/10.1126\/science.1209791","journal-title":"Science"},{"key":"1026_CR16","doi-asserted-by":"publisher","first-page":"e1006512","DOI":"10.1371\/journal.ppat.1006512","volume":"13","author":"SA Ragland","year":"2017","unstructured":"Ragland SA, Criss AK (2017) From bacterial killing to immune modulation: Recent insights into the functions of lysozyme. PLoS Pathog 13:e1006512. https:\/\/doi.org\/10.1371\/journal.ppat.1006512","journal-title":"PLoS Pathog"},{"key":"1026_CR17","doi-asserted-by":"publisher","first-page":"13057","DOI":"10.1016\/S0021-9258(17)36794-7","volume":"269","author":"EA Dennis","year":"1994","unstructured":"Dennis EA (1994) Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 269:13057\u201313060","journal-title":"J Biol Chem"},{"key":"1026_CR18","doi-asserted-by":"publisher","first-page":"G957","DOI":"10.1152\/ajpgi.2001.281.4.G957","volume":"281","author":"RA Rozenfeld","year":"2001","unstructured":"Rozenfeld RA, Liu X, DePlaen I, Hsueh W (2001) Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. Am J Physiol Gastrointest Liver Physiol 281:G957-963. https:\/\/doi.org\/10.1152\/ajpgi.2001.281.4.G957","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1026_CR19","doi-asserted-by":"publisher","first-page":"11027","DOI":"10.1073\/pnas.1711395114","volume":"114","author":"DC Propheter","year":"2017","unstructured":"Propheter DC, Chara AL, Harris TA, Ruhn KA, Hooper LV (2017) Resistin-like molecule beta is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc Natl Acad Sci U S A 114:11027\u201311033. https:\/\/doi.org\/10.1073\/pnas.1711395114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jaci.2006.04.039","volume":"118","author":"SP Hogan","year":"2006","unstructured":"Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME (2006) Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol 118:257\u2013268. https:\/\/doi.org\/10.1016\/j.jaci.2006.04.039","journal-title":"J Allergy Clin Immunol"},{"key":"1026_CR21","doi-asserted-by":"publisher","first-page":"eabe6723","DOI":"10.1126\/science.abe6723","volume":"374","author":"Z Hu","year":"2021","unstructured":"Hu Z, Zhang C, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA, Hooper LV (2021) Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science 374:eabe6723. https:\/\/doi.org\/10.1126\/science.abe6723","journal-title":"Science"},{"key":"1026_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ni888","volume":"4","author":"LV Hooper","year":"2003","unstructured":"Hooper LV, Stappenbeck TS, Hong CV, Gordon JI (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 4:269\u2013273. https:\/\/doi.org\/10.1038\/ni888","journal-title":"Nat Immunol"},{"key":"1026_CR23","doi-asserted-by":"publisher","first-page":"900948","DOI":"10.3389\/fmicb.2022.900948","volume":"13","author":"MF Sultana","year":"2022","unstructured":"Sultana MF, Suzuki M, Yamasaki F, Kubota W, Takahashi K, Abo H, Kawashima H (2022) Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice. Front Microbiol 13:900948. https:\/\/doi.org\/10.3389\/fmicb.2022.900948","journal-title":"Front Microbiol"},{"key":"1026_CR24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature09637","volume":"469","author":"T Sato","year":"2011","unstructured":"Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469:415\u2013418. https:\/\/doi.org\/10.1038\/nature09637","journal-title":"Nature"},{"key":"1026_CR25","doi-asserted-by":"publisher","first-page":"15451","DOI":"10.1073\/pnas.202604299","volume":"99","author":"TS Stappenbeck","year":"2002","unstructured":"Stappenbeck TS, Hooper LV, Gordon JI (2002) Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A 99:15451\u201315455. https:\/\/doi.org\/10.1073\/pnas.202604299","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR26","doi-asserted-by":"publisher","first-page":"47248","DOI":"10.1074\/jbc.M208483200","volume":"277","author":"K Godl","year":"2002","unstructured":"Godl K, Johansson ME, Lidell ME, Morgelin M, Karlsson H, Olson FJ, Gum JR Jr, Kim YS, Hansson GC (2002) The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem 277:47248\u201347256. https:\/\/doi.org\/10.1074\/jbc.M208483200","journal-title":"J Biol Chem"},{"key":"1026_CR27","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1016\/j.jmb.2014.04.027","volume":"426","author":"HE Nilsson","year":"2014","unstructured":"Nilsson HE, Ambort D, Backstrom M, Thomsson E, Koeck PJB, Hansson GC, Hebert H (2014) Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J Mol Biol 426:2567\u20132579. https:\/\/doi.org\/10.1016\/j.jmb.2014.04.027","journal-title":"J Mol Biol"},{"key":"1026_CR28","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/glycob\/cwt045","volume":"23","author":"KS Bergstrom","year":"2013","unstructured":"Bergstrom KS, Xia L (2013) Mucin-type O-glycans and their roles in intestinal homeostasis. Glycobiology 23:1026\u20131037. https:\/\/doi.org\/10.1093\/glycob\/cwt045","journal-title":"Glycobiology"},{"key":"1026_CR29","doi-asserted-by":"publisher","first-page":"15064","DOI":"10.1073\/pnas.0803124105","volume":"105","author":"ME Johansson","year":"2008","unstructured":"Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 105:15064\u201315069. https:\/\/doi.org\/10.1073\/pnas.0803124105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR30","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.aay7367","volume":"370","author":"K Bergstrom","year":"2020","unstructured":"Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L (2020) Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science 370:467\u2013472. https:\/\/doi.org\/10.1126\/science.aay7367","journal-title":"Science"},{"key":"1026_CR31","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1084\/jem.20061929","volume":"204","author":"G An","year":"2007","unstructured":"An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L (2007) Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med 204:1417\u20131429. https:\/\/doi.org\/10.1084\/jem.20061929","journal-title":"J Exp Med"},{"key":"1026_CR32","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1172\/JCI45538","volume":"121","author":"J Fu","year":"2011","unstructured":"Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L (2011) Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest 121:1657\u20131666. https:\/\/doi.org\/10.1172\/JCI45538","journal-title":"J Clin Invest"},{"issue":"1172\u20131188","key":"1026_CR33","doi-asserted-by":"publisher","first-page":"e1128","DOI":"10.1016\/j.cell.2022.02.013","volume":"185","author":"Y Yao","year":"2022","unstructured":"Yao Y, Kim G, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, Park AY, Jiang P, Li J, Baris S, Aydiner EK, Ertem D, Mulder DJ, Warner N, Griffiths AM, Topf-Olivestone C, Kori M, Werner L, Ouahed J, Field M, Liu C, Schwarz B, Bosio CM, Ganesan S, Song J, Urlaub H, Oellerich T, Malaker SA, Zheng L, Bertozzi CR, Zhang Y, Matthews H, Montgomery W, Shih HY, Jiang J, Jones M, Baras A, Shuldiner A, Gonzaga-Jauregui C, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan KT, Wu C, Lenardo MJ (2022) Mucus sialylation determines intestinal host-commensal homeostasis. Cell 185(1172\u20131188):e1128. https:\/\/doi.org\/10.1016\/j.cell.2022.02.013","journal-title":"Cell"},{"key":"1026_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2023.06.004","author":"M Taniguchi","year":"2023","unstructured":"Taniguchi M, Okumura R, Matsuzaki T, Nakatani A, Sakaki K, Okamoto S, Ishibashi A, Tani H, Horikiri M, Kobayashi N, Yoshikawa HY, Motooka D, Okuzaki D, Nakamura S, Kida T, Kameyama A, Takeda K (2023) Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Mucosal Immunol. https:\/\/doi.org\/10.1016\/j.mucimm.2023.06.004","journal-title":"Mucosal Immunol"},{"key":"1026_CR35","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/glycob\/cww134","volume":"27","author":"L Arike","year":"2017","unstructured":"Arike L, Holmen-Larsson J, Hansson GC (2017) Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. Glycobiology 27:318\u2013328. https:\/\/doi.org\/10.1093\/glycob\/cww134","journal-title":"Glycobiology"},{"key":"1026_CR36","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature17406","volume":"532","author":"R Okumura","year":"2016","unstructured":"Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, Takeda K (2016) Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532:117\u2013121. https:\/\/doi.org\/10.1038\/nature17406","journal-title":"Nature"},{"key":"1026_CR37","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s41232-017-0056-3","volume":"37","author":"CC Hsu","year":"2017","unstructured":"Hsu CC, Okumura R, Takeda K (2017) Human LYPD8 protein inhibits motility of flagellated bacteria. Inflamm Regen 37:23. https:\/\/doi.org\/10.1186\/s41232-017-0056-3","journal-title":"Inflamm Regen"},{"key":"1026_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41385-019-0219-4","volume":"13","author":"R Okumura","year":"2020","unstructured":"Okumura R, Kodama T, Hsu CC, Sahlgren BH, Hamano S, Kurakawa T, Iida T, Takeda K (2020) Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia. Mucosal Immunol 13:75\u201385. https:\/\/doi.org\/10.1038\/s41385-019-0219-4","journal-title":"Mucosal Immunol"},{"issue":"550","key":"1026_CR39","doi-asserted-by":"publisher","first-page":"eaaw0720","DOI":"10.1126\/scitranslmed.aaw0720","volume":"12","author":"T Ara","year":"2020","unstructured":"Ara T, Hashimoto D, Hayase E, Noizat C, Kikuchi R, Hasegawa Y, Matsuda K, Ono S, Matsuno Y, Ebata K, Ogasawara R, Takahashi S, Ohigashi H, Yokoyama E, Matsuo K, Sugita J, Onozawa M, Okumura R, Takeda K, Teshima T (2020) Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8. Sci Transl Med 12(550):eaaw0720. https:\/\/doi.org\/10.1126\/scitranslmed.aaw0720","journal-title":"Sci Transl Med"},{"key":"1026_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1159\/000453594","volume":"9","author":"JPM van Putten","year":"2017","unstructured":"van Putten JPM, Strijbis K (2017) Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer. J Innate Immun 9:281\u2013299. https:\/\/doi.org\/10.1159\/000453594","journal-title":"J Innate Immun"},{"key":"1026_CR41","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1053\/j.gastro.2007.07.003","volume":"133","author":"MA McGuckin","year":"2007","unstructured":"McGuckin MA, Every AL, Skene CD, Linden SK, Chionh YT, Swierczak A, McAuley J, Harbour S, Kaparakis M, Ferrero R, Sutton P (2007) Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology 133:1210\u20131218. https:\/\/doi.org\/10.1053\/j.gastro.2007.07.003","journal-title":"Gastroenterology"},{"key":"1026_CR42","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1172\/JCI26705","volume":"117","author":"JL McAuley","year":"2007","unstructured":"McAuley JL, Linden SK, Png CW, King RM, Pennington HL, Gendler SJ, Florin TH, Hill GR, Korolik V, McGuckin MA (2007) MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest 117:2313\u20132324. https:\/\/doi.org\/10.1172\/JCI26705","journal-title":"J Clin Invest"},{"key":"1026_CR43","doi-asserted-by":"publisher","first-page":"e1000617","DOI":"10.1371\/journal.ppat.1000617","volume":"5","author":"SK Linden","year":"2009","unstructured":"Linden SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA (2009) MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog 5:e1000617. https:\/\/doi.org\/10.1371\/journal.ppat.1000617","journal-title":"PLoS Pathog"},{"key":"1026_CR44","doi-asserted-by":"publisher","first-page":"e70303","DOI":"10.1371\/journal.pone.0070303","volume":"8","author":"C Zhou","year":"2013","unstructured":"Zhou C, Liu Z, Liu Y, Fu W, Ding X, Liu J, Yu Y, Zhang Q (2013) Gene silencing of porcine MUC13 and ITGB5: candidate genes towards Escherichia coli F4ac adhesion. PLoS ONE 8:e70303. https:\/\/doi.org\/10.1371\/journal.pone.0070303","journal-title":"PLoS ONE"},{"key":"1026_CR45","doi-asserted-by":"publisher","first-page":"G1144","DOI":"10.1152\/ajpgi.00138.2010","volume":"300","author":"S Resta-Lenert","year":"2011","unstructured":"Resta-Lenert S, Das S, Batra SK, Ho SB (2011) Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity. Am J Physiol Gastrointest Liver Physiol 300:G1144-1155. https:\/\/doi.org\/10.1152\/ajpgi.00138.2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1026_CR46","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","volume":"70","author":"T Suzuki","year":"2013","unstructured":"Suzuki T (2013) Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci 70:631\u2013659. https:\/\/doi.org\/10.1007\/s00018-012-1070-x","journal-title":"Cell Mol Life Sci"},{"key":"1026_CR47","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1053\/j.gastro.2007.11.040","volume":"134","author":"A Tamura","year":"2008","unstructured":"Tamura A, Kitano Y, Hata M, Katsuno T, Moriwaki K, Sasaki H, Hayashi H, Suzuki Y, Noda T, Furuse M, Tsukita S, Tsukita S (2008) Megaintestine in claudin-15-deficient mice. Gastroenterology 134:523\u2013534. https:\/\/doi.org\/10.1053\/j.gastro.2007.11.040","journal-title":"Gastroenterology"},{"key":"1026_CR48","doi-asserted-by":"publisher","first-page":"8011","DOI":"10.1073\/pnas.0912901107","volume":"107","author":"S Muto","year":"2010","unstructured":"Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M (2010) Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A 107:8011\u20138016. https:\/\/doi.org\/10.1073\/pnas.0912901107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR49","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1053\/j.gastro.2011.10.025","volume":"142","author":"L Ding","year":"2012","unstructured":"Ding L, Lu Z, Foreman O, Tatum R, Lu Q, Renegar R, Cao J, Chen YH (2012) Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice. Gastroenterology 142:305\u2013315. https:\/\/doi.org\/10.1053\/j.gastro.2011.10.025","journal-title":"Gastroenterology"},{"key":"1026_CR50","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","volume":"158","author":"NW Palm","year":"2014","unstructured":"Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA (2014) Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158:1000\u20131010. https:\/\/doi.org\/10.1016\/j.cell.2014.08.006","journal-title":"Cell"},{"key":"1026_CR51","doi-asserted-by":"publisher","first-page":"2323220","DOI":"10.1080\/19490976.2024.2323220","volume":"16","author":"W Tang","year":"2024","unstructured":"Tang W, Wei Y, Ni Z, Hou K, Luo XM, Wang H (2024) IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation. Gut Microbes 16:2323220. https:\/\/doi.org\/10.1080\/19490976.2024.2323220","journal-title":"Gut Microbes"},{"issue":"6361","key":"1026_CR52","doi-asserted-by":"publisher","first-page":"eaan6619","DOI":"10.1126\/science.aan6619","volume":"358","author":"JJ Bunker","year":"2017","unstructured":"Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A (2017) Natural polyreactive IgA antibodies coat the intestinal microbiota. Science 358(6361):eaan6619. https:\/\/doi.org\/10.1126\/science.aan6619","journal-title":"Science"},{"key":"1026_CR53","doi-asserted-by":"publisher","first-page":"8124","DOI":"10.1038\/s41467-023-44007-2","volume":"14","author":"C Eriksen","year":"2023","unstructured":"Eriksen C, Moll JM, Myers PN, Pinto ARA, Danneskiold-Samsoe NB, Dehli RI, Rosholm LB, Dalgaard MD, Penders J, Jonkers DM, Pan-Hammarstrom Q, Hammarstrom L, Kristiansen K, Brix S (2023) IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency. Nat Commun 14:8124. https:\/\/doi.org\/10.1038\/s41467-023-44007-2","journal-title":"Nat Commun"},{"key":"1026_CR54","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.1038\/s41598-019-49923-2","volume":"9","author":"JR Catanzaro","year":"2019","unstructured":"Catanzaro JR, Strauss JD, Bielecka A, Porto AF, Lobo FM, Urban A, Schofield WB, Palm NW (2019) IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Sci Rep 9:13574. https:\/\/doi.org\/10.1038\/s41598-019-49923-2","journal-title":"Sci Rep"},{"key":"1026_CR55","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jcmgh.2018.01.024","volume":"6","author":"J Marchix","year":"2018","unstructured":"Marchix J, Goddard G, Helmrath MA (2018) Host-Gut Microbiota Crosstalk in Intestinal Adaptation. Cell Mol Gastroenterol Hepatol 6:149\u2013162. https:\/\/doi.org\/10.1016\/j.jcmgh.2018.01.024","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1026_CR56","doi-asserted-by":"publisher","first-page":"G177","DOI":"10.1152\/ajpgi.00307.2002","volume":"285","author":"A Venkatraman","year":"2003","unstructured":"Venkatraman A, Ramakrishna BS, Shaji RV, Kumar NS, Pulimood A, Patra S (2003) Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB. Am J Physiol Gastrointest Liver Physiol 285:G177-184. https:\/\/doi.org\/10.1152\/ajpgi.00307.2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1026_CR57","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1136\/gut.46.4.493","volume":"46","author":"MS Ahmad","year":"2000","unstructured":"Ahmad MS, Krishnan S, Ramakrishna BS, Mathan M, Pulimood AB, Murthy SN (2000) Butyrate and glucose metabolism by colonocytes in experimental colitis in mice. Gut 46:493\u2013499","journal-title":"Gut"},{"key":"1026_CR58","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1126\/science.aam9949","volume":"357","author":"MX Byndloss","year":"2017","unstructured":"Byndloss MX, Olsan EE, Rivera-Chavez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Baumler AJ (2017) Microbiota-activated PPAR-gamma signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357:570\u2013575. https:\/\/doi.org\/10.1126\/science.aam9949","journal-title":"Science"},{"key":"1026_CR59","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1095-6433(00)00183-5","volume":"125","author":"A Shimotoyodome","year":"2000","unstructured":"Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T (2000) Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon. Comp Biochem Physiol A Mol Integr Physiol 125:525\u2013531","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"1026_CR60","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1136\/gut.36.1.93","volume":"36","author":"IA Finnie","year":"1995","unstructured":"Finnie IA, Dwarakanath AD, Taylor BA, Rhodes JM (1995) Colonic mucin synthesis is increased by sodium butyrate. Gut 36:93\u201399","journal-title":"Gut"},{"key":"1026_CR61","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/gut.46.2.218","volume":"46","author":"A Barcelo","year":"2000","unstructured":"Barcelo A, Claustre J, Moro F, Chayvialle JA, Cuber JC, Plaisancie P (2000) Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon. Gut 46:218\u2013224","journal-title":"Gut"},{"key":"1026_CR62","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0300-9629(95)00033-4","volume":"111","author":"T Sakata","year":"1995","unstructured":"Sakata T, Setoyama H (1995) Local stimulatory effect of short-chain fatty acids on the mucus release from the hindgut mucosa of rats (Rattus norvegicus). Comp Biochem Physiol A Physiol 111:429\u2013432","journal-title":"Comp Biochem Physiol A Physiol"},{"key":"1026_CR63","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1042\/BJ20082222","volume":"420","author":"N Burger-van Paassen","year":"2009","unstructured":"Burger-van Paassen N, Vincent A, Puiman PJ, van der Sluis M, Bouma J, Boehm G, van Goudoever JB, van Seuningen I, Renes IB (2009) The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. Biochem J 420:211\u2013219. https:\/\/doi.org\/10.1042\/BJ20082222","journal-title":"Biochem J"},{"issue":"33\u201341","key":"1026_CR64","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.immuni.2018.06.016","volume":"49","author":"MS Nadjsombati","year":"2018","unstructured":"Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J (2018) Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity 49(33\u201341):e37. https:\/\/doi.org\/10.1016\/j.immuni.2018.06.016","journal-title":"Immunity"},{"key":"1026_CR65","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature16527","volume":"529","author":"F Gerbe","year":"2016","unstructured":"Gerbe F, Sidot E, Smyth DJ, Ohmoto M, Matsumoto I, Dardalhon V, Cesses P, Garnier L, Pouzolles M, Brulin B, Bruschi M, Harcus Y, Zimmermann VS, Taylor N, Maizels RM, Jay P (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529:226\u2013230. https:\/\/doi.org\/10.1038\/nature16527","journal-title":"Nature"},{"key":"1026_CR66","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature16161","volume":"529","author":"J von Moltke","year":"2016","unstructured":"von Moltke J, Ji M, Liang HE, Locksley RM (2016) Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529:221\u2013225. https:\/\/doi.org\/10.1038\/nature16161","journal-title":"Nature"},{"key":"1026_CR67","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s00018-008-7568-6","volume":"65","author":"AF Hofmann","year":"2008","unstructured":"Hofmann AF, Hagey LR (2008) Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 65:2461\u20132483. https:\/\/doi.org\/10.1007\/s00018-008-7568-6","journal-title":"Cell Mol Life Sci"},{"key":"1026_CR68","doi-asserted-by":"publisher","first-page":"G259","DOI":"10.1152\/ajpgi.00354.2017","volume":"315","author":"JM Golden","year":"2018","unstructured":"Golden JM, Escobar OH, Nguyen MVL, Mallicote MU, Kavarian P, Frey MR, Gayer CP (2018) Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol 315:G259\u2013G271. https:\/\/doi.org\/10.1152\/ajpgi.00354.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1026_CR69","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/j.gastro.2012.09.055","volume":"144","author":"F Alemi","year":"2013","unstructured":"Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU (2013) The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144:145\u2013154. https:\/\/doi.org\/10.1053\/j.gastro.2012.09.055","journal-title":"Gastroenterology"},{"key":"1026_CR70","doi-asserted-by":"publisher","first-page":"12689","DOI":"10.1038\/srep12689","volume":"5","author":"TD Hubbard","year":"2015","unstructured":"Hubbard TD, Murray IA, Bisson WH, Lahoti TS, Gowda K, Amin SG, Patterson AD, Perdew GH (2015) Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles. Sci Rep 5:12689. https:\/\/doi.org\/10.1038\/srep12689","journal-title":"Sci Rep"},{"key":"1026_CR71","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1124\/dmd.115.064246","volume":"43","author":"TD Hubbard","year":"2015","unstructured":"Hubbard TD, Murray IA, Perdew GH (2015) Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation. Drug Metab Dispos 43:1522\u20131535. https:\/\/doi.org\/10.1124\/dmd.115.064246","journal-title":"Drug Metab Dispos"},{"key":"1026_CR72","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.immuni.2014.06.014","volume":"41","author":"M Venkatesh","year":"2014","unstructured":"Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S (2014) Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41:296\u2013310. https:\/\/doi.org\/10.1016\/j.immuni.2014.06.014","journal-title":"Immunity"},{"issue":"353\u2013362","key":"1026_CR73","doi-asserted-by":"publisher","first-page":"e355","DOI":"10.1016\/j.immuni.2018.07.010","volume":"49","author":"A Metidji","year":"2018","unstructured":"Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B (2018) The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity. Immunity 49(353\u2013362):e355. https:\/\/doi.org\/10.1016\/j.immuni.2018.07.010","journal-title":"Immunity"},{"key":"1026_CR74","doi-asserted-by":"publisher","first-page":"e80604","DOI":"10.1371\/journal.pone.0080604","volume":"8","author":"Y Shimada","year":"2013","unstructured":"Shimada Y, Kinoshita M, Harada K, Mizutani M, Masahata K, Kayama H, Takeda K (2013) Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS ONE 8:e80604. https:\/\/doi.org\/10.1371\/journal.pone.0080604","journal-title":"PLoS ONE"},{"key":"1026_CR75","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/77783","volume":"1","author":"T Ayabe","year":"2000","unstructured":"Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113\u2013118. https:\/\/doi.org\/10.1038\/77783","journal-title":"Nat Immunol"},{"key":"1026_CR76","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1128\/IAI.02045-14","volume":"82","author":"G Bhinder","year":"2014","unstructured":"Bhinder G, Stahl M, Sham HP, Crowley SM, Morampudi V, Dalwadi U, Ma C, Jacobson K, Vallance BA (2014) Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses. Infect Immun 82:3753\u20133763. https:\/\/doi.org\/10.1128\/IAI.02045-14","journal-title":"Infect Immun"},{"issue":"560\u2013575","key":"1026_CR77","doi-asserted-by":"publisher","first-page":"e566","DOI":"10.1016\/j.immuni.2018.07.016","volume":"49","author":"AE Price","year":"2018","unstructured":"Price AE, Shamardani K, Lugo KA, Deguine J, Roberts AW, Lee BL, Barton GM (2018) A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns. Immunity 49(560\u2013575):e566. https:\/\/doi.org\/10.1016\/j.immuni.2018.07.016","journal-title":"Immunity"},{"key":"1026_CR78","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/mi.2012.23mi201223[pii]","volume":"5","author":"AL Frantz","year":"2012","unstructured":"Frantz AL, Rogier EW, Weber CR, Shen L, Cohen DA, Fenton LA, Bruno ME, Kaetzel CS (2012) Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol 5:501\u2013512. https:\/\/doi.org\/10.1038\/mi.2012.23mi201223[pii]","journal-title":"Mucosal Immunol"},{"key":"1026_CR79","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/3507910735079107[pii]","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O\u2019Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature 411:599\u2013603. https:\/\/doi.org\/10.1038\/3507910735079107[pii]","journal-title":"Nature"},{"key":"1026_CR80","doi-asserted-by":"publisher","first-page":"14739","DOI":"10.1073\/pnas.1003363107","volume":"107","author":"A Biswas","year":"2010","unstructured":"Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS (2010) Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc Natl Acad Sci U S A 107:14739\u201314744. https:\/\/doi.org\/10.1073\/pnas.1003363107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR81","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease. Nature 411:603\u2013606. https:\/\/doi.org\/10.1038\/35079114","journal-title":"Nature"},{"key":"1026_CR82","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058S0092-8674(15)01110-1[pii]","volume":"163","author":"K Atarashi","year":"2015","unstructured":"Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nunez G, Camp JG, Hattori M, Umesaki Y, Honda K (2015) Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. Cell 163:367\u2013380. https:\/\/doi.org\/10.1016\/j.cell.2015.08.058S0092-8674(15)01110-1[pii]","journal-title":"Cell"},{"key":"1026_CR83","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033S0092-8674(09)01248-3[pii]","volume":"139","author":"II Ivanov","year":"2009","unstructured":"Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485\u2013498. https:\/\/doi.org\/10.1016\/j.cell.2009.09.033S0092-8674(09)01248-3[pii]","journal-title":"Cell"},{"key":"1026_CR84","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1084\/jem.20061308","volume":"203","author":"SC Liang","year":"2006","unstructured":"Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271\u20132279. https:\/\/doi.org\/10.1084\/jem.20061308","journal-title":"J Exp Med"},{"key":"1026_CR85","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2015.08.061S0092-8674(15)01113-7[pii]","volume":"163","author":"T Sano","year":"2015","unstructured":"Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR (2015) An IL-23R\/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell 163:381\u2013393. https:\/\/doi.org\/10.1016\/j.cell.2015.08.061S0092-8674(15)01113-7[pii]","journal-title":"Cell"},{"key":"1026_CR86","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-024-07288-1","volume":"629","author":"CL Zindl","year":"2024","unstructured":"Zindl CL, Wilson CG, Chadha AS, Duck LW, Cai B, Harbour SN, Nagaoka-Kamata Y, Hatton RD, Gao M, Figge DA, Weaver CT (2024) Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence. Nature 629:669\u2013678. https:\/\/doi.org\/10.1038\/s41586-024-07288-1","journal-title":"Nature"},{"issue":"943\u2013957","key":"1026_CR87","doi-asserted-by":"publisher","first-page":"e949","DOI":"10.1016\/j.immuni.2018.09.011","volume":"49","author":"AR Fatkhullina","year":"2018","unstructured":"Fatkhullina AR, Peshkova IO, Dzutsev A, Aghayev T, McCulloch JA, Thovarai V, Badger JH, Vats R, Sundd P, Tang HY, Kossenkov AV, Hazen SL, Trinchieri G, Grivennikov SI, Koltsova EK (2018) An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis. Immunity 49(943\u2013957):e949. https:\/\/doi.org\/10.1016\/j.immuni.2018.09.011","journal-title":"Immunity"},{"key":"1026_CR88","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2015.12.047","volume":"164","author":"T Sano","year":"2016","unstructured":"Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR (2016) An IL-23R\/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell 164:324. https:\/\/doi.org\/10.1016\/j.cell.2015.12.047","journal-title":"Cell"},{"key":"1026_CR89","doi-asserted-by":"publisher","first-page":"e20192195","DOI":"10.1084\/jem.20192195","volume":"217","author":"M Keir","year":"2020","unstructured":"Keir M, Yi Y, Lu T, Ghilardi N (2020) The role of IL-22 in intestinal health and disease. J Exp Med 217:e20192195. https:\/\/doi.org\/10.1084\/jem.20192195","journal-title":"J Exp Med"},{"key":"1026_CR90","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.immuni.2011.12.011","volume":"36","author":"MA Kinnebrew","year":"2012","unstructured":"Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36:276\u2013287. https:\/\/doi.org\/10.1016\/j.immuni.2011.12.011","journal-title":"Immunity"},{"key":"1026_CR91","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1172\/JCI33194","volume":"118","author":"K Sugimoto","year":"2008","unstructured":"Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A (2008) IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 118:534\u2013544. https:\/\/doi.org\/10.1172\/JCI33194","journal-title":"J Clin Invest"},{"issue":"671\u2013681","key":"1026_CR92","doi-asserted-by":"publisher","first-page":"e674","DOI":"10.1016\/j.chom.2017.05.009","volume":"21","author":"PY Tsai","year":"2017","unstructured":"Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR (2017) IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe 21(671\u2013681):e674. https:\/\/doi.org\/10.1016\/j.chom.2017.05.009","journal-title":"Cell Host Microbe"},{"key":"1026_CR93","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nm1720","volume":"14","author":"Y Zheng","year":"2008","unstructured":"Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, Ouyang W (2008) Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14:282\u2013289. https:\/\/doi.org\/10.1038\/nm1720","journal-title":"Nat Med"},{"key":"1026_CR94","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature16460","volume":"528","author":"CA Lindemans","year":"2015","unstructured":"Lindemans CA, Calafiore M, Mertelsmann AM, O\u2019Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O\u2019Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM (2015) Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 528:560\u2013564. https:\/\/doi.org\/10.1038\/nature16460","journal-title":"Nature"},{"key":"1026_CR95","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.13065","author":"A Nakatani","year":"2023","unstructured":"Nakatani A, Okumura R, Ishibashi A, Okamoto S, Sakaki K, Ito Y, Okuzaki D, Inohara H, Takeda K (2023) Differential dependence on microbiota of IL-23\/IL-22-dependent gene expression between the small- and large-intestinal epithelia. Genes Cells. https:\/\/doi.org\/10.1111\/gtc.13065","journal-title":"Genes Cells"},{"key":"1026_CR96","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","volume":"44","author":"P Kumar","year":"2016","unstructured":"Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK (2016) Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. Immunity 44:659\u2013671. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.007","journal-title":"Immunity"},{"key":"1026_CR97","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.immuni.2015.09.003","volume":"43","author":"JS Lee","year":"2015","unstructured":"Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein WM, Judo M, Ayanoglu G, McClanahan TK, Li X, Cua DJ (2015) Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity 43:727\u2013738. https:\/\/doi.org\/10.1016\/j.immuni.2015.09.003","journal-title":"Immunity"},{"issue":"237\u2013253","key":"1026_CR98","doi-asserted-by":"publisher","first-page":"e238","DOI":"10.1016\/j.immuni.2021.12.016","volume":"55","author":"X Lin","year":"2022","unstructured":"Lin X, Gaudino SJ, Jang KK, Bahadur T, Singh A, Banerjee A, Beaupre M, Chu T, Wong HT, Kim CK, Kempen C, Axelrad J, Huang H, Khalid S, Shah V, Eskiocak O, Parks OB, Berisha A, McAleer JP, Good M, Hoshino M, Blumberg R, Bialkowska AB, Gaffen SL, Kolls JK, Yang VW, Beyaz S, Cadwell K, Kumar P (2022) IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity 55(237\u2013253):e238. https:\/\/doi.org\/10.1016\/j.immuni.2021.12.016","journal-title":"Immunity"},{"issue":"1307\u20131320","key":"1026_CR99","doi-asserted-by":"publisher","first-page":"e1322","DOI":"10.1016\/j.cell.2018.10.008","volume":"175","author":"M Biton","year":"2018","unstructured":"Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ (2018) T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell 175(1307\u20131320):e1322. https:\/\/doi.org\/10.1016\/j.cell.2018.10.008","journal-title":"Cell"},{"key":"1026_CR100","doi-asserted-by":"publisher","first-page":"G139","DOI":"10.1152\/ajpgi.00386.2007","volume":"294","author":"X Sun","year":"2008","unstructured":"Sun X, Yang H, Nose K, Nose S, Haxhija EQ, Koga H, Feng Y, Teitelbaum DH (2008) Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 294:G139-147. https:\/\/doi.org\/10.1152\/ajpgi.00386.2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"357\u2013368","key":"1026_CR101","doi-asserted-by":"publisher","first-page":"e359","DOI":"10.1053\/j.gastro.2012.10.043","volume":"144","author":"SZ Hasnain","year":"2013","unstructured":"Hasnain SZ, Tauro S, Das I, Tong H, Chen AC, Jeffery PL, McDonald V, Florin TH, McGuckin MA (2013) IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology 144(357\u2013368):e359. https:\/\/doi.org\/10.1053\/j.gastro.2012.10.043","journal-title":"Gastroenterology"},{"key":"1026_CR102","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1084\/jem.179.1.347","volume":"179","author":"KJ Else","year":"1994","unstructured":"Else KJ, Finkelman FD, Maliszewski CR, Grencis RK (1994) Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med 179:347\u2013351. https:\/\/doi.org\/10.1084\/jem.179.1.347","journal-title":"J Exp Med"},{"key":"1026_CR103","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-3024.2006.00908.x","volume":"29","author":"RA Webb","year":"2007","unstructured":"Webb RA, Hoque T, Dimas S (2007) Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion. Parasite Immunol 29:11\u201321. https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00908.x","journal-title":"Parasite Immunol"},{"key":"1026_CR104","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1084\/jem.20130753","volume":"211","author":"HF Farin","year":"2014","unstructured":"Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H (2014) Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-gamma. J Exp Med 211:1393\u20131405. https:\/\/doi.org\/10.1084\/jem.20130753","journal-title":"J Exp Med"},{"key":"1026_CR105","doi-asserted-by":"publisher","first-page":"G1279","DOI":"10.1152\/ajpgi.1999.276.5.G1279","volume":"276","author":"A Youakim","year":"1999","unstructured":"Youakim A, Ahdieh M (1999) Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol 276:G1279-1288. https:\/\/doi.org\/10.1152\/ajpgi.1999.276.5.G1279","journal-title":"Am J Physiol"},{"key":"1026_CR106","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1096\/fj.04-3260com","volume":"19","author":"M Bruewer","year":"2005","unstructured":"Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A (2005) Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 19:923\u2013933. https:\/\/doi.org\/10.1096\/fj.04-3260com","journal-title":"FASEB J"},{"key":"1026_CR107","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/labinvest.2010.208","volume":"91","author":"D Smyth","year":"2011","unstructured":"Smyth D, Phan V, Wang A, McKay DM (2011) Interferon-gamma-induced increases in intestinal epithelial macromolecular permeability requires the Src kinase Fyn. Lab Invest 91:764\u2013777. https:\/\/doi.org\/10.1038\/labinvest.2010.208","journal-title":"Lab Invest"},{"key":"1026_CR108","doi-asserted-by":"publisher","unstructured":"Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ (2018) Essential role of IFN-gamma in T cell-associated intestinal inflammation. JCI Insight 3(18). https:\/\/doi.org\/10.1172\/jci.insight.121886","DOI":"10.1172\/jci.insight.121886"},{"key":"1026_CR109","doi-asserted-by":"publisher","first-page":"e2204269120","DOI":"10.1073\/pnas.2204269120","volume":"120","author":"T Yokoi","year":"2023","unstructured":"Yokoi T, Murakami M, Kihara T, Seno S, Arase M, Wing JB, Sondergaard JN, Kuwahara R, Minagawa T, Oguro-Igashira E, Motooka D, Okuzaki D, Mori R, Ikeda A, Sekido Y, Amano T, Iijima H, Ozono K, Mizushima T, Hirota S, Ikeuchi H, Takeda K (2023) Identification of a unique subset of tissue-resident memory CD4(+) T cells in Crohn\u2019s disease. Proc Natl Acad Sci U S A 120:e2204269120. https:\/\/doi.org\/10.1073\/pnas.2204269120","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR110","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1016\/j.celrep.2016.04.049","volume":"15","author":"M Mahapatro","year":"2016","unstructured":"Mahapatro M, Foersch S, Hefele M, He GW, Giner-Ventura E, McHedlidze T, Kindermann M, Vetrano S, Danese S, Gunther C, Neurath MF, Wirtz S, Becker C (2016) Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection. Cell Rep 15:1743\u20131756. https:\/\/doi.org\/10.1016\/j.celrep.2016.04.049","journal-title":"Cell Rep"},{"key":"1026_CR111","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2020.02.004","volume":"180","author":"A Jarret","year":"2020","unstructured":"Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Velez K, Hartner S, Low JS, Qu R, de Zoete MR, Palm NW, Ring AM, Weber A, Moor AE, Kluger Y, Nowarski R, Flavell RA (2020) Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell 180:813\u2013814. https:\/\/doi.org\/10.1016\/j.cell.2020.02.004","journal-title":"Cell"},{"key":"1026_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1\u20139. https:\/\/doi.org\/10.1038\/s12276-018-0126-x","journal-title":"Exp Mol Med"},{"key":"1026_CR113","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/emm.2017.20","volume":"49","author":"R Okumura","year":"2017","unstructured":"Okumura R, Takeda K (2017) Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Exp Mol Med 49:e338. https:\/\/doi.org\/10.1038\/emm.2017.20","journal-title":"Exp Mol Med"},{"key":"1026_CR114","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.diff.2008.09.008","volume":"77","author":"M Gersemann","year":"2009","unstructured":"Gersemann M, Becker S, Kubler I, Koslowski M, Wang G, Herrlinger KR, Griger J, Fritz P, Fellermann K, Schwab M, Wehkamp J, Stange EF (2009) Differences in goblet cell differentiation between Crohn\u2019s disease and ulcerative colitis. Differentiation 77:84\u201394. https:\/\/doi.org\/10.1016\/j.diff.2008.09.008","journal-title":"Differentiation"},{"key":"1026_CR115","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","volume":"131","author":"M Van der Sluis","year":"2006","unstructured":"Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Buller HA, Dekker J, Van Seuningen I, Renes IB, Einerhand AW (2006) Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131:117\u2013129. https:\/\/doi.org\/10.1053\/j.gastro.2006.04.020","journal-title":"Gastroenterology"},{"key":"1026_CR116","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1002\/ibd.21625","volume":"17","author":"JM Larsson","year":"2011","unstructured":"Larsson JM, Karlsson H, Crespo JG, Johansson ME, Eklund L, Sjovall H, Hansson GC (2011) Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis 17:2299\u20132307. https:\/\/doi.org\/10.1002\/ibd.21625","journal-title":"Inflamm Bowel Dis"},{"key":"1026_CR117","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","volume":"42","author":"A Franke","year":"2010","unstructured":"Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D\u2019Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D\u2019Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci. Nat Genet 42:1118\u20131125. https:\/\/doi.org\/10.1038\/ng.717","journal-title":"Nat Genet"},{"key":"1026_CR118","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1093\/hmg\/ddq248","volume":"19","author":"McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI, International IBDGC","year":"2010","unstructured":"McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI, International IBDGC (2010) Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn\u2019s disease. Hum Mol Genet 19:3468\u20133476. https:\/\/doi.org\/10.1093\/hmg\/ddq248","journal-title":"Hum Mol Genet"},{"key":"1026_CR119","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.3748\/wjg.v18.i34.4758","volume":"18","author":"A Aheman","year":"2012","unstructured":"Aheman A, Luo HS, Gao F (2012) Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China. World J Gastroenterol 18:4758\u20134764. https:\/\/doi.org\/10.3748\/wjg.v18.i34.4758","journal-title":"World J Gastroenterol"},{"key":"1026_CR120","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/tan.12016","volume":"80","author":"AS Parmar","year":"2012","unstructured":"Parmar AS, Alakulppi N, Paavola-Sakki P, Kurppa K, Halme L, Farkkila M, Turunen U, Lappalainen M, Kontula K, Kaukinen K, Maki M, Lindfors K, Partanen J, Sistonen P, Matto J, Wacklin P, Saavalainen P, Einarsdottir E (2012) Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population. Tissue Antigens 80:488\u2013493. https:\/\/doi.org\/10.1111\/tan.12016","journal-title":"Tissue Antigens"},{"key":"1026_CR121","doi-asserted-by":"publisher","first-page":"940196","DOI":"10.3389\/fmicb.2022.940196","volume":"13","author":"M Hu","year":"2022","unstructured":"Hu M, Zhang X, Li J, Chen L, He X, Sui T (2022) Fucosyltransferase 2: A Genetic Risk Factor for Intestinal Diseases. Front Microbiol 13:940196. https:\/\/doi.org\/10.3389\/fmicb.2022.940196","journal-title":"Front Microbiol"},{"key":"1026_CR122","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12929-021-00711-z","volume":"28","author":"X Tang","year":"2021","unstructured":"Tang X, Wang W, Hong G, Duan C, Zhu S, Tian Y, Han C, Qian W, Lin R, Hou X (2021) Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency. J Biomed Sci 28:20. https:\/\/doi.org\/10.1186\/s12929-021-00711-z","journal-title":"J Biomed Sci"},{"issue":"714\u2013730","key":"1026_CR123","doi-asserted-by":"publisher","first-page":"e722","DOI":"10.1016\/j.cell.2019.06.029","volume":"178","author":"CS Smillie","year":"2019","unstructured":"Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A (2019) Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell 178(714\u2013730):e722. https:\/\/doi.org\/10.1016\/j.cell.2019.06.029","journal-title":"Cell"},{"key":"1026_CR124","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1053\/j.gastro.2020.09.036","volume":"160","author":"J Zhang","year":"2021","unstructured":"Zhang J, Hoedt EC, Liu Q, Berendsen E, Teh JJ, Hamilton A, AW OB, Ching JYL, Wei H, Yang K, Xu Z, Wong SH, Mak JWY, Sung JJY, Morrison M, Yu J, Kamm MA, Ng SC (2021) Elucidation of Proteus mirabilis as a Key Bacterium in Crohn\u2019s Disease Inflammation. Gastroenterology 160:317-330 e311. https:\/\/doi.org\/10.1053\/j.gastro.2020.09.036","journal-title":"Gastroenterology"},{"key":"1026_CR125","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/intimm\/dxab012","volume":"33","author":"CC Hsu","year":"2021","unstructured":"Hsu CC, Okumura R, Motooka D, Sasaki R, Nakamura S, Iida T, Takeda K (2021) Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease. Int Immunol 33:359\u2013372. https:\/\/doi.org\/10.1093\/intimm\/dxab012","journal-title":"Int Immunol"},{"key":"1026_CR126","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1136\/gut.2006.118646","volume":"56","author":"S Nuding","year":"2007","unstructured":"Nuding S, Fellermann K, Wehkamp J, Stange EF (2007) Reduced mucosal antimicrobial activity in Crohn\u2019s disease of the colon. Gut 56:1240\u20131247. https:\/\/doi.org\/10.1136\/gut.2006.118646","journal-title":"Gut"},{"key":"1026_CR127","doi-asserted-by":"publisher","first-page":"18129","DOI":"10.1073\/pnas.0505256102","volume":"102","author":"J Wehkamp","year":"2005","unstructured":"Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL (2005) Reduced Paneth cell alpha-defensins in ileal Crohn\u2019s disease. Proc Natl Acad Sci U S A 102:18129\u201318134. https:\/\/doi.org\/10.1073\/pnas.0505256102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1026_CR128","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1136\/gut.2007.142588","volume":"57","author":"LA Simms","year":"2008","unstructured":"Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL (2008) Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn\u2019s disease. Gut 57:903\u2013910. https:\/\/doi.org\/10.1136\/gut.2007.142588","journal-title":"Gut"},{"key":"1026_CR129","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1136\/gut.2003.032805","volume":"53","author":"J Wehkamp","year":"2004","unstructured":"Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schroder JM, Bevins CL, Fellermann K, Stange EF (2004) NOD2 (CARD15) mutations in Crohn\u2019s disease are associated with diminished mucosal alpha-defensin expression. Gut 53:1658\u20131664. https:\/\/doi.org\/10.1136\/gut.2003.032805","journal-title":"Gut"},{"key":"1026_CR130","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","volume":"29","author":"LA Zenewicz","year":"2008","unstructured":"Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA (2008) Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29:947\u2013957. https:\/\/doi.org\/10.1016\/j.immuni.2008.11.003","journal-title":"Immunity"},{"key":"1026_CR131","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","volume":"41","author":"R Caruso","year":"2014","unstructured":"Caruso R, Warner N, Inohara N, Nunez G (2014) NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41:898\u2013908. https:\/\/doi.org\/10.1016\/j.immuni.2014.12.010","journal-title":"Immunity"},{"key":"1026_CR132","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/ng.3359","volume":"47","author":"Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK, International Multiple Sclerosis Genetics C, International IBDGC, Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA, Weersma RK","year":"2015","unstructured":"Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK, International Multiple Sclerosis Genetics C, International IBDGC, Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA, Weersma RK (2015) Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet 47:979\u2013986. https:\/\/doi.org\/10.1038\/ng.3359","journal-title":"Nat Genet"},{"key":"1026_CR133","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022S0092-8674(11)00480-6[pii]","volume":"145","author":"E Elinav","year":"2011","unstructured":"Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745\u2013757. https:\/\/doi.org\/10.1016\/j.cell.2011.04.022S0092-8674(11)00480-6[pii]","journal-title":"Cell"},{"key":"1026_CR134","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","volume":"156","author":"M Wlodarska","year":"2014","unstructured":"Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156:1045\u20131059. https:\/\/doi.org\/10.1016\/j.cell.2014.01.026","journal-title":"Cell"},{"key":"1026_CR135","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41577-022-00727-y","volume":"23","author":"E Miyauchi","year":"2023","unstructured":"Miyauchi E, Shimokawa C, Steimle A, Desai MS, Ohno H (2023) The impact of the gut microbiome on extra-intestinal autoimmune diseases. Nat Rev Immunol 23:9\u201323. https:\/\/doi.org\/10.1038\/s41577-022-00727-y","journal-title":"Nat Rev Immunol"},{"issue":"733\u2013746","key":"1026_CR136","doi-asserted-by":"publisher","first-page":"e712","DOI":"10.1053\/j.gastro.2016.06.022","volume":"151","author":"K Rahman","year":"2016","unstructured":"Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA (2016) Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol. Gastroenterology 151(733\u2013746):e712. https:\/\/doi.org\/10.1053\/j.gastro.2016.06.022","journal-title":"Gastroenterology"},{"key":"1026_CR137","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41586-020-2724-8","volume":"585","author":"M Nikolaev","year":"2020","unstructured":"Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, Elci B, Brandenberg N, Kolotuev I, Gjorevski N, Clevers H, Lutolf MP (2020) Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature 585:574\u2013578. https:\/\/doi.org\/10.1038\/s41586-020-2724-8","journal-title":"Nature"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-024-01026-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-024-01026-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-024-01026-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:30:53Z","timestamp":1778661053000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-024-01026-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":137,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1026"],"URL":"https:\/\/doi.org\/10.1007\/s00281-024-01026-5","relation":{},"ISSN":["1863-2297","1863-2300"],"issn-type":[{"value":"1863-2297","type":"print"},{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"2"}}