{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:58:10Z","timestamp":1780937890383,"version":"3.54.1"},"reference-count":311,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82575124"],"award-info":[{"award-number":["82575124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82474559"],"award-info":[{"award-number":["82474559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["No. ZR2023LZY024"],"award-info":[{"award-number":["No. ZR2023LZY024"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Semin Immunopathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adenomyosis is a common and difficult disease in gynecology. Its main clinical manifestations include uterine hypertrophy, excessive menstruation, pelvic pain and infertility, which have a serious impact on women\u2019s health. Seriously affects women\u2019s health. At present, the pathogenesis of this disease is not clear; however, the increase in local estrogen and the occurrence of an inflammatory response are widely believed to be closely related to the development of adenomyotic lesions. Although progress has been made in understanding how estrogen and inflammation play their respective roles in adenomyosis, the relationship between estrogen and inflammation and its impact on adenomyosis are not fully understood. In this work, we summarize the effects of estrogen and inflammation on the occurrence and development of adenomyosis, including the involved biological processes and related signal transduction mechanisms, as well as the targeted drugs for clinical treatment, and further summarize the interactions between the two in adenomyosis as well as the available evidence for clinical applications. This review helps to broaden our understanding of the role of the vicious inflammatory\u2012estrogen cycle in the pathogenesis and pathophysiology of adenomyosis, and it provides new ideas for the treatment of uterine adenomyosis.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>The vicious cycle of inflammation and estrogen promotes the development of adenomyosis.<\/jats:p>","DOI":"10.1007\/s00281-026-01077-w","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:18:15Z","timestamp":1780928295000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies"],"prefix":"10.1007","volume":"48","author":[{"given":"Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng Juan","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"1077_CR1","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1093\/humrep\/des332","volume":"27","author":"J Naftalin","year":"2012","unstructured":"Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D (2012) How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod 27:3432\u20133439","journal-title":"Hum Reprod"},{"key":"1077_CR2","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/uog.15798","volume":"47","author":"J Naftalin","year":"2016","unstructured":"Naftalin J, Hoo W, Nunes N, Holland T, Mavrelos D, Jurkovic D (2016) Association between ultrasound features of adenomyosis and severity of menstrual pain. Ultrasound Obstet Gynecol 47:779\u2013783","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1077_CR3","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/uog.14834","volume":"46","author":"S Pinzauti","year":"2015","unstructured":"Pinzauti S, Lazzeri L, Tosti C, Centini G, Orlandini C, Luisi S, Zupi E, Exacoustos C, Petraglia F (2015) Transvaginal sonographic features of diffuse adenomyosis in 18-30-year-old nulligravid women without endometriosis: Association with symptoms. Ultrasound Obstet Gynecol 46:730\u2013736","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1077_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1055\/s-0040-1718920","volume":"38","author":"K Upson","year":"2020","unstructured":"Upson K, Missmer SA (2020) Epidemiology of adenomyosis. Semin Reprod Med 38:89\u2013107","journal-title":"Semin Reprod Med"},{"key":"1077_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1001\/jama.2020.26436","volume":"326","author":"KA Kho","year":"2021","unstructured":"Kho KA, Chen JS, Halvorson LM (2021) Diagnosis, evaluation, and treatment of adenomyosis. JAMA 326:177\u2013178","journal-title":"JAMA"},{"key":"1077_CR6","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.fertnstert.2023.03.018","volume":"119","author":"P Vercellini","year":"2023","unstructured":"Vercellini P, Vigan\u00f2 P, Bandini V, Buggio L, Berlanda N, Somigliana E (2023) Association of endometriosis and adenomyosis with pregnancy and infertility. Fertil Steril 119:727\u2013740","journal-title":"Fertil Steril"},{"key":"1077_CR7","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s40265-023-01957-7","volume":"83","author":"A Etrusco","year":"2023","unstructured":"Etrusco A, Barra F, Chiantera V, Ferrero S, Bogliolo S, Evangelisti G, Oral E, Pastore M, Izzotti A, Venezia R, Ceccaroni M, Lagan\u00e0 AS (2023) Current medical therapy for adenomyosis: From bench to bedside. Drugs 83:1595\u20131611","journal-title":"Drugs"},{"key":"1077_CR8","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1093\/humupd\/dmab017","volume":"27","author":"SE Bulun","year":"2021","unstructured":"Bulun SE, Yildiz S, Adli M, Wei JJ (2021) Adenomyosis pathogenesis: Insights from next-generation sequencing. Hum Reprod Update 27:1086\u20131097","journal-title":"Hum Reprod Update"},{"key":"1077_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0889-8545(02)00053-0","volume":"30","author":"IM Matalliotakis","year":"2003","unstructured":"Matalliotakis IM, Kourtis AI, Panidis DK (2003) Adenomyosis. Obstet Gynecol Clin North Am 30:63\u201382","journal-title":"Obstet Gynecol Clin North Am"},{"key":"1077_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2217\/WHE.12.8","volume":"8","author":"G Benagiano","year":"2012","unstructured":"Benagiano G, Brosens I (2012) The endometrium in adenomyosis. Womens Health (Lond) 8:301\u2013312","journal-title":"Womens Health (Lond)"},{"key":"1077_CR11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.bpobgyn.2006.01.016","volume":"20","author":"C Bergeron","year":"2006","unstructured":"Bergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511\u201321","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"1077_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0002-9440(10)61733-6","volume":"159","author":"E Parrott","year":"2001","unstructured":"Parrott E, Butterworth M, Green A, White IN, Greaves P (2001) Adenomyosis\u2013a result of disordered stromal differentiation. Am J Pathol 159:623\u2013630","journal-title":"Am J Pathol"},{"key":"1077_CR13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.fertnstert.2017.12.030","volume":"109","author":"J Garc\u00eda-Solares","year":"2018","unstructured":"Garc\u00eda-Solares J, Donnez J, Donnez O, Dolmans MM (2018) Pathogenesis of uterine adenomyosis: invagination or metaplasia? Fertil Steril 109:371\u2013379","journal-title":"Fertil Steril"},{"key":"1077_CR14","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/humupd\/dmz049","volume":"26","author":"C Chapron","year":"2020","unstructured":"Chapron C, Vannuccini S, Santulli P, Abr\u00e3o MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, No\u00ebl JC, Pistofidis G, Van den Bosch T, Petraglia F (2020) Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum Reprod Update 26:392\u2013411","journal-title":"Hum Reprod Update"},{"key":"1077_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00404-009-1191-0","volume":"280","author":"G Leyendecker","year":"2009","unstructured":"Leyendecker G, Wildt L, Mall G (2009) The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 280:529\u201338","journal-title":"Arch Gynecol Obstet"},{"key":"1077_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10237-014-0614-4","volume":"14","author":"S Shaked","year":"2015","unstructured":"Shaked S, Jaffa AJ, Grisaru D, Elad D (2015) Uterine peristalsis-induced stresses within the uterine wall may sprout adenomyosis. Biomech Model Mechanobiol 14:437\u2013444","journal-title":"Biomech Model Mechanobiol"},{"key":"1077_CR17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/humupd\/dmw011","volume":"22","author":"CE Gargett","year":"2016","unstructured":"Gargett CE, Schwab KE, Deane JA (2016) Endometrial stem\/progenitor cells: the first 10 years. Hum Reprod Update 22:137\u2013163","journal-title":"Hum Reprod Update"},{"key":"1077_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/humupd\/dml045","volume":"13","author":"CE Gargett","year":"2007","unstructured":"Gargett CE (2007) Uterine stem cells: what is the evidence? Hum Reprod Update 13:87\u2013101","journal-title":"Hum Reprod Update"},{"key":"1077_CR19","doi-asserted-by":"crossref","unstructured":"Martire FG, Costantini E, D\u2019Abate C, Schettini G, Sorrenti G, Centini G, Zupi E, Lazzeri L (2025) Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up. Curr Issues Mol Biol 47","DOI":"10.3390\/cimb47050298"},{"key":"1077_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/01.pgp.0000130109.80359.57","volume":"23","author":"K Ueki","year":"2004","unstructured":"Ueki K, Kumagai K, Yamashita H, Li ZL, Ueki M, Otsuki Y (2004) Expression of apoptosis-related proteins in adenomyotic uteri treated with danazol and GnRH agonists. Int J Gynecol Pathol 23:248\u2013258","journal-title":"Int J Gynecol Pathol"},{"key":"1077_CR21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/S0140-6736(95)92474-4","volume":"346","author":"R Gaetje","year":"1995","unstructured":"Gaetje R, Kotzian S, Herrmann G, Baumann R, Starzinski-Powitz A (1995) Invasiveness of endometriotic cells in vitro. Lancet 346:1463\u20134","journal-title":"Lancet"},{"key":"1077_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/humupd\/dmg010","volume":"9","author":"R Devlieger","year":"2003","unstructured":"Devlieger R, D\u2019Hooghe T, Timmerman D (2003) Uterine adenomyosis in the infertility clinic. Hum Reprod Update 9:139\u201347","journal-title":"Hum Reprod Update"},{"key":"1077_CR23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/00006254-200006000-00025","volume":"55","author":"AS Uduwela","year":"2000","unstructured":"Uduwela AS, Perera MA, Aiqing L, Fraser IS (2000) Endometrial-myometrial interface: relationship to adenomyosis and changes in pregnancy. Obstet Gynecol Surv 55:390\u2013400","journal-title":"Obstet Gynecol Surv"},{"key":"1077_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1055\/s-0040-1716687","volume":"38","author":"J Zhai","year":"2020","unstructured":"Zhai J, Vannuccini S, Petraglia F, Giudice LC (2020) Adenomyosis: Mechanisms and Pathogenesis. Semin Reprod Med 38:129\u2013143","journal-title":"Semin Reprod Med"},{"key":"1077_CR25","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00404-014-3437-8","volume":"291","author":"G Leyendecker","year":"2015","unstructured":"Leyendecker G, Bilgicyildirim A, Inacker M, Stalf T, Huppert P, Mall G, B\u00f6ttcher B, Wildt L (2015) Adenomyosis and endometriosis. Re-visiting their association and further insights into the mechanisms of auto-traumatisation. An MRI study. Arch Gynecol Obstet 291:917\u201332","journal-title":"Arch Gynecol Obstet"},{"key":"1077_CR26","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.rbmo.2017.06.016","volume":"35","author":"S Vannuccini","year":"2017","unstructured":"Vannuccini S, Tosti C, Carmona F, Huang SJ, Chapron C, Guo S-W, Petraglia F (2017) Pathogenesis of adenomyosis: an update on molecular mechanisms. Reprod Biomed Online 35:592\u2013601","journal-title":"Reprod Biomed Online"},{"key":"1077_CR27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.gene.2005.08.006","volume":"363","author":"G Yang","year":"2005","unstructured":"Yang G, Im H-J, Wang JHC (2005) Repetitive mechanical stretching modulates IL-1\u03b2 induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene 363:166\u2013172","journal-title":"Gene"},{"key":"1077_CR28","first-page":"600","volume":"82","author":"LS Noble","year":"1997","unstructured":"Noble LS, Takayama K, Zeitoun KM, Putman JM, Johns DA, Hinshelwood MM, Agarwal VR, Zhao Y, Carr BR, Bulun SE (1997) Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells*. J Clin Endocrinol Metab 82:600\u20136","journal-title":"J Clin Endocrinol Metab"},{"key":"1077_CR29","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1016\/j.fertnstert.2010.01.070","volume":"94","author":"Y-J Chen","year":"2010","unstructured":"Chen Y-J, Li H-Y, Chang Y-L, Yuan C-C, Tai L-K, Lu KH, Chang C-M, Chiou S-H (2010) Suppression of migratory\/invasive ability and induction of apoptosis in adenomyosis-derived mesenchymal stem cells by cyclooxygenase-2 inhibitors. Fertil Steril 94:1972\u20139.e4","journal-title":"Fertil Steril"},{"key":"1077_CR30","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1177\/1933719116657192","volume":"24","author":"P Carrarelli","year":"2017","unstructured":"Carrarelli P, Yen C-F, Funghi L, Arcuri F, Tosti C, Bifulco G, Luddi A, Lee C-L, Petraglia F (2017) Expression of Inflammatory and Neurogenic Mediators in Adenomyosis: A Pathogenetic Role. Reprod Sci 24:369\u2013375","journal-title":"Reprod Sci"},{"key":"1077_CR31","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.fertnstert.2020.04.017","volume":"114","author":"O Donnez","year":"2020","unstructured":"Donnez O, Donnez J (2020) Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis. Fertil Steril 114:640\u2013645","journal-title":"Fertil Steril"},{"key":"1077_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245794","author":"J Donnez","year":"2021","unstructured":"Donnez J, Donnez O, Tourniaire J, Brethous M, Bestel E, Garner E, Charpentier S, Humberstone A, Loumaye E (2021) Uterine adenomyosis treated by Linzagolix, an oral gonadotropin-releasing hormone receptor antagonist: a pilot study with a new \u201cHit Hard First and then Maintain\u201d regimen of administration. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10245794","journal-title":"J Clin Med"},{"key":"1077_CR33","volume":"9","author":"M Bofill Rodriguez","year":"2019","unstructured":"Bofill Rodriguez M, Lethaby A, Farquhar C (2019) Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev 9:Cd000400","journal-title":"Cochrane Database Syst Rev"},{"key":"1077_CR34","doi-asserted-by":"crossref","unstructured":"Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M (2015) Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 2015: Cd001751","DOI":"10.1002\/14651858.CD001751.pub3"},{"key":"1077_CR35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.fertnstert.2013.09.042","volume":"101","author":"AH Taylor","year":"2014","unstructured":"Taylor AH, Kalathy V, Habiba M (2014) Estradiol and tamoxifen enhance invasion of endometrial stromal cells in a three-dimensional coculture model of adenomyosis. Fertil Steril 101:288\u2013293","journal-title":"Fertil Steril"},{"key":"1077_CR36","first-page":"383","volume":"37","author":"YY Zeng","year":"2017","unstructured":"Zeng YY, Guan YG, Li KY (2017) [Role of estrogen, estrogen receptors, and aromatase in the pathogenesis of uterine adenomyosis]. Nan Fang Yi Ke Da Xue Xue Bao 37:383\u20137","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"1077_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154407","author":"M Sztachelska","year":"2022","unstructured":"Sztachelska M, Ponikwicka-Tyszko D, Mart\u00ednez-Rodrigo L, Bernaczyk P, Palak E, P\u00f3\u0142ch\u0142opek W, Bielawski T, Wo\u0142czy\u0144ski S (2022) Functional implications of estrogen and progesterone receptors expression in adenomyosis, potential targets for endocrinological therapy. J Clin Med. https:\/\/doi.org\/10.3390\/jcm11154407","journal-title":"J Clin Med"},{"key":"1077_CR38","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11976","author":"JH Huang","year":"2021","unstructured":"Huang JH, Duan H, Wang S, Wang YY (2021) Estrogen 17\u03b2\u2011estradiol accelerates the proliferation of uterine junctional zone smooth muscle cells via the let\u20117a\/Lin28B axis in adenomyosis. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2021.11976","journal-title":"Mol Med Rep"},{"key":"1077_CR39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/path.2761","volume":"222","author":"YJ Chen","year":"2010","unstructured":"Chen YJ, Li HY, Huang CH, Twu NF, Yen MS, Wang PH, Chou TY, Liu YN, Chao KC, Yang MH (2010) Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis. J Pathol 222:261\u2013270","journal-title":"J Pathol"},{"key":"1077_CR40","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1046\/j.1365-2559.1997.4910725.x","volume":"30","author":"KT Mai","year":"1997","unstructured":"Mai KT, Yazdi HM, Perkins DG, Parks W (1997) Pathogenetic role of the stromal cells in endometriosis and adenomyosis. Histopathology 30:430\u2013442","journal-title":"Histopathology"},{"key":"1077_CR41","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.fertnstert.2023.01.041","volume":"119","author":"S Yildiz","year":"2023","unstructured":"Yildiz S, Kinali M, Wei JJ, Milad M, Yin P, Adli M, Bulun SE (2023) Adenomyosis: single-cell transcriptomic analysis reveals a paracrine mesenchymal-epithelial interaction involving the WNT\/SFRP pathway. Fertil Steril 119:869\u2013882","journal-title":"Fertil Steril"},{"key":"1077_CR42","doi-asserted-by":"publisher","first-page":"9658","DOI":"10.1111\/jcmm.15495","volume":"24","author":"X He","year":"2020","unstructured":"He X, Liu N, Mu T, Lu D, Jia C, Wang S, Yin C, Liu L, Zhou L, Huang X, Ma Y (2020) Oestrogen induces epithelial-mesenchymal transition in endometriosis via circ_0004712\/miR-148a-3p sponge function. J Cell Mol Med 24:9658\u20139666","journal-title":"J Cell Mol Med"},{"key":"1077_CR43","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/jcmm.12300","volume":"18","author":"TS Huang","year":"2014","unstructured":"Huang TS, Chen YJ, Chou TY, Chen CY, Li HY, Huang BS, Tsai HW, Lan HY, Chang CH, Twu NF, Yen MS, Wang PH, Chao KC, Lee CC, Yang MH (2014) Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells. J Cell Mol Med 18:1358\u20131371","journal-title":"J Cell Mol Med"},{"key":"1077_CR44","doi-asserted-by":"crossref","unstructured":"Zhang Z, Qin Y, Huang J, Wang Y, Zeng L, Wang Y, Zhuyun F, Wang L (2024) Oestrogen promotes the progression of adenomyosis by inhibiting\u2009<\u2009em>CITED2 through miR-145. Reprod Biomed Online 49","DOI":"10.1016\/j.rbmo.2024.104108"},{"key":"1077_CR45","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/0002-9378(93)90654-2","volume":"169","author":"T Yamamoto","year":"1993","unstructured":"Yamamoto T, Noguchi T, Tamura T, Kitawaki J, Okada H (1993) Evidence for estrogen synthesis in adenomyotic tissues. Am J Obstet Gynecol 169:734\u2013738","journal-title":"Am J Obstet Gynecol"},{"key":"1077_CR46","first-page":"1849","volume":"41","author":"K Takahashi","year":"1989","unstructured":"Takahashi K, Nagata H, Kitao M (1989) Clinical usefulness of determination of estradiol level in the menstrual blood for patients with endometriosis. Nihon Sanka Fujinka Gakkai Zasshi 41:1849\u20131850","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"1077_CR47","doi-asserted-by":"crossref","unstructured":"Wang Y, Qu Y, Song W (2015) Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis. 42:168\u2013172","DOI":"10.12891\/ceog1747.2015"},{"key":"1077_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejogrb.2014.04.039","volume":"179","author":"X Tong","year":"2014","unstructured":"Tong X, Li Z, Wu Y, Fu X, Zhang Y, Fan H (2014) COMT 158G\/A and CYP1B1 432 C\/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 179:17\u201321","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1077_CR49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0960-0760(02)00260-1","volume":"83","author":"J Kitawaki","year":"2002","unstructured":"Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol 83:149\u2013155","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1077_CR50","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.7150\/ijbs.35128","volume":"15","author":"ZZ Lai","year":"2019","unstructured":"Lai ZZ, Yang HL, Ha SY, Chang KK, Mei J, Zhou WJ, Qiu XM, Wang XQ, Zhu R, Li DJ, Li MQ (2019) Cyclooxygenase-2 in endometriosis. Int J Biol Sci 15:2783\u20132797","journal-title":"Int J Biol Sci"},{"key":"1077_CR51","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10815-016-0862-6","volume":"34","author":"F Ji","year":"2017","unstructured":"Ji F, Yang X, He Y, Wang H, Aili A, Ding Y (2017) Aberrant endometrial DNA methylome of homeobox A10 and catechol-O-methyltransferase in endometriosis. J Assist Reprod Genet 34:409\u2013415","journal-title":"J Assist Reprod Genet"},{"key":"1077_CR52","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.4067\/S0034-98872004001200004","volume":"132","author":"MC Johnson","year":"2004","unstructured":"Johnson MC, Pinto C, Alves A, Palomino A, Fuentes A, Boric MA, Vega M (2004) [P450Arom and estrogenic microenvironment of eutopic endometria in endometriosis]. Rev Med Chil 132:1475\u201382","journal-title":"Rev Med Chil"},{"key":"1077_CR53","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1095\/biolreprod57.3.514","volume":"57","author":"J Kitawaki","year":"1997","unstructured":"Kitawaki J, Noguchi T, Amatsu T, Maeda K, Tsukamoto K, Yamamoto T, Fushiki S, Osawa Y, Honjo H (1997) Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol Reprod 57:514\u2013519","journal-title":"Biol Reprod"},{"key":"1077_CR54","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1210\/jcem.87.7.8683","volume":"87","author":"Z Fang","year":"2002","unstructured":"Fang Z, Yang S, Gurates B, Tamura M, Simpson E, Evans D, Bulun SE (2002) Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. J Clin Endocrinol Metab 87:3460\u20133466","journal-title":"J Clin Endocrinol Metab"},{"key":"1077_CR55","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/S0015-0282(99)00424-0","volume":"72","author":"J Kitawaki","year":"1999","unstructured":"Kitawaki J, Kusuki I, Koshiba H, Tsukamoto K, Fushiki S, Honjo H (1999) Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis. Fertil Steril 72:1100\u20131106","journal-title":"Fertil Steril"},{"key":"1077_CR56","first-page":"213","volume":"73","author":"J Visnovsk\u00fd","year":"2008","unstructured":"Visnovsk\u00fd J, Galo S, Z\u00fabor P, Hatok J, Racay P, Danko J (2008) [Semiquantitative analysis of mRNA aromatase expression in eutopic endometrium as a diagnostic marker of endometriosis and estrogen dependent diseases]. Ceska Gynekol 73:213\u20137","journal-title":"Ceska Gynekol"},{"key":"1077_CR57","first-page":"727","volume":"19","author":"C Li","year":"2019","unstructured":"Li C, Chen R, Jiang C, Chen L, Cheng Z (2019) Correlation of LOX\u20135 and COX\u20132 expression with inflammatory pathology and clinical features of adenomyosis. Mol Med Rep 19:727\u2013733","journal-title":"Mol Med Rep"},{"key":"1077_CR58","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2217\/WHE.12.52","volume":"8","author":"H Maia Jr.","year":"2012","unstructured":"Maia H Jr., Haddad C, Coelho G, Casoy J (2012) Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. Womens Health (Lond) 8:647\u201358","journal-title":"Womens Health (Lond)"},{"key":"1077_CR59","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/humupd\/dmi034","volume":"12","author":"E Attar","year":"2006","unstructured":"Attar E, Bulun SE (2006) Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update 12:49\u201356","journal-title":"Hum Reprod Update"},{"key":"1077_CR60","first-page":"1","volume":"44","author":"W Siei\u0144ski","year":"1993","unstructured":"Siei\u0144ski W (1993) Tumor-like intravascular proliferations of the stroma in adenomyosis. Patol Pol 44:1\u20134","journal-title":"Patol Pol"},{"key":"1077_CR61","first-page":"1969","volume":"193","author":"JP Thiery","year":"2009","unstructured":"Thiery JP (2009) [Epithelial-mesenchymal transitions in cancer onset and progression]. Bull Acad Natl Med 193:1969\u201378","journal-title":"Bull Acad Natl Med"},{"key":"1077_CR62","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/PGP.0b013e318182c2be","volume":"28","author":"G Goteri","year":"2009","unstructured":"Goteri G, Lucarini G, Montik N, Zizzi A, Stramazzotti D, Fabris G, Tranquilli AL, Ciavattini A (2009) Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1alpha (HIF-1alpha), and microvessel density in endometrial tissue in women with adenomyosis. Int J Gynecol Pathol 28:157\u2013163","journal-title":"Int J Gynecol Pathol"},{"key":"1077_CR63","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.017988","volume":"11","author":"S Zhou","year":"2012","unstructured":"Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X, Huang C, Wei Y (2012) Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics 11:M112.017988","journal-title":"Mol Cell Proteomics"},{"key":"1077_CR64","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12958-021-00756-7","volume":"19","author":"YY Wang","year":"2021","unstructured":"Wang YY, Duan H, Wang S, Quan YJ, Huang JH, Guo ZC (2021) Upregulated Talin1 synergistically boosts \u03b2-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis. Reprod Biol Endocrinol 19:70","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR65","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s43032-020-00444-8","volume":"28","author":"YY Wang","year":"2021","unstructured":"Wang YY, Duan H, Wang S, Quan YJ, Huang JH, Guo ZC (2021) Talin1 induces epithelial-mesenchymal transition to facilitate endometrial cell migration and invasion in Adenomyosis under the regulation of microRNA-145-5p. Reprod Sci 28:1523\u20131539","journal-title":"Reprod Sci"},{"key":"1077_CR66","first-page":"5461","volume":"18","author":"D Zheng","year":"2018","unstructured":"Zheng D, Duan H, Wang S, Xu Q, Gan L, Li J, Dong Q (2018) FAK regulates epithelial\u2013mesenchymal transition in Adenomyosis. Mol Med Rep 18:5461\u20135472","journal-title":"Mol Med Rep"},{"key":"1077_CR67","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1016\/j.bpj.2020.02.023","volume":"118","author":"Z Haydari","year":"2020","unstructured":"Haydari Z, Shams H, Jahed Z, Mofrad MRK (2020) Kindlin assists Talin to promote Integrin activation. Biophys J 118:1977\u20131991","journal-title":"Biophys J"},{"key":"1077_CR68","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1161\/CIRCRESAHA.118.314560","volume":"124","author":"FE Pulous","year":"2019","unstructured":"Pulous FE, Grimsley-Myers CM, Kansal S, Kowalczyk AP, Petrich BG (2019) Talin-dependent Integrin activation regulates VE-Cadherin localization and endothelial cell barrier function. Circ Res 124:891\u2013903","journal-title":"Circ Res"},{"key":"1077_CR69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.ctdb.2016.11.006","volume":"123","author":"A Di Cristofano","year":"2017","unstructured":"Di Cristofano A (2017) SGK1: the dark side of PI3K signaling. Curr Top Dev Biol 123:49\u201371","journal-title":"Curr Top Dev Biol"},{"key":"1077_CR70","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41388-018-0430-x","volume":"38","author":"J Zhang","year":"2019","unstructured":"Zhang J, Zhou Y, Huang T, Wu F, Pan Y, Dong Y, Wang Y, Chan AKY, Liu L, Kwan JSH, Cheung AHK, Wong CC, Lo AKF, Cheng ASL, Yu J, Lo KW, Kang W, To KF (2019) FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p. Oncogene 38:33\u201346","journal-title":"Oncogene"},{"key":"1077_CR71","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3892\/or.2016.5301","volume":"37","author":"T Chen","year":"2017","unstructured":"Chen T, Gong W, Tian H, Wang H, Chu S, Ma J, Yang H, Cheng J, Liu M, Li X, Jiang C (2017) Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways. Oncol Rep 37:1235\u20131242","journal-title":"Oncol Rep"},{"key":"1077_CR72","doi-asserted-by":"publisher","first-page":"6767","DOI":"10.2147\/CMAR.S254242","volume":"12","author":"J Wu","year":"2020","unstructured":"Wu J, Tao X, Zhang H, Yi XH, Yu YH (2020) Estrogen-induced stromal FGF18 promotes proliferation and invasion of endometrial carcinoma cells through ERK and Akt signaling. Cancer Manag Res 12:6767\u20136777","journal-title":"Cancer Manag Res"},{"key":"1077_CR73","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1158\/0008-5472.CAN-17-2105","volume":"77","author":"A Orlacchio","year":"2017","unstructured":"Orlacchio A, Ranieri M, Brave M, Arciuch VA, Forde T, De Martino D, Anderson KE, Hawkins P, Di Cristofano A (2017) SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance. Cancer Res 77:6914\u201326","journal-title":"Cancer Res"},{"key":"1077_CR74","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1042\/BJ20130342","volume":"452","author":"EM Sommer","year":"2013","unstructured":"Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR (2013) Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. Biochem J 452:499\u2013508","journal-title":"Biochem J"},{"key":"1077_CR75","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1007\/s43032-022-00990-3","volume":"29","author":"Y Wu","year":"2022","unstructured":"Wu Y, Wang H, Li Y, Li Y, Liang Y, Zhong G, Zhang Q (2022) Estrogen-increased SGK1 promotes endometrial stromal cell invasion in adenomyosis by regulating with LPAR2. Reprod Sci 29:3026\u20133038","journal-title":"Reprod Sci"},{"key":"1077_CR76","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12958-023-01102-9","volume":"21","author":"Y Lou","year":"2023","unstructured":"Lou Y, Fu Z, Tian Y, Hu M, Wang Q, Zhou Y, Wang N, Zhang Q, Jin F (2023) Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal-fetal interface. Reprod Biol Endocrinol 21:50","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR77","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/liv.13495","volume":"38","author":"H Zhu","year":"2018","unstructured":"Zhu H, Jiang X, Zhou X, Dong X, Xie K, Yang C, Jiang H, Sun X, Lu J (2018) Neuropilin-1 regulated by miR-320 contributes to the growth and metastasis of cholangiocarcinoma cells. Liver Int 38:125\u2013135","journal-title":"Liver Int"},{"key":"1077_CR78","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1002\/ijc.31645","volume":"143","author":"M Kiso","year":"2018","unstructured":"Kiso M, Tanaka S, Saji S, Toi M, Sato F (2018) Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1\/ARHGAP17\/Cdc42 regulatory network. Int J Cancer 143:2905\u20132918","journal-title":"Int J Cancer"},{"key":"1077_CR79","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s43032-019-00035-2","volume":"27","author":"R Hu","year":"2020","unstructured":"Hu R, Peng GQ, Ban DY, Zhang C, Zhang XQ, Li YP (2020) High-expression of Neuropilin 1 correlates to estrogen-induced epithelial-mesenchymal transition of endometrial cells in adenomyosis. Reprod Sci 27:395\u2013403","journal-title":"Reprod Sci"},{"key":"1077_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2020.101474","volume":"69","author":"N Huang","year":"2021","unstructured":"Huang N, Xu L, Qiu Y, Zhan J, Chen X (2021) Down-regulated miR-124-3p enhanced the migration and epithelial-stromal transformation of endometrial stromal cells extracted from eutopic endometrium in subjects with adenomyosis by up-regulating Neuropilin 1. Tissue Cell 69:101474","journal-title":"Tissue Cell"},{"key":"1077_CR81","volume":"215","author":"J Li","year":"2019","unstructured":"Li J, Yanyan M, Mu L, Chen X, Zheng W (2019) The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells. Pathology 215:152477","journal-title":"Pathology"},{"key":"1077_CR82","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/09513590.2020.1816723","volume":"36","author":"M Orazov","year":"2020","unstructured":"Orazov M, Radzinsky V, Sharapova O, Kostin I, Chitanava Y (2020) Oxytocinergic regulation in pathogenesis of pelvic pain caused by adenomyosis. Gynecol Endocrinol 36:20\u201323","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR83","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1210\/en.2005-1120","volume":"147","author":"JG Fleming","year":"2006","unstructured":"Fleming JG, Spencer TE, Safe SH, Bazer FW (2006) Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. Endocrinology 147:899\u2013911","journal-title":"Endocrinology"},{"key":"1077_CR84","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.bpobgyn.2006.01.010","volume":"20","author":"J Kitawaki","year":"2006","unstructured":"Kitawaki J (2006) Adenomyosis: the pathophysiology of an oestrogen-dependent disease. Best Pract Res Clin Obstet Gynaecol 20:493\u2013502","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"1077_CR85","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/0090-6980(88)90149-9","volume":"35","author":"T Wilson","year":"1988","unstructured":"Wilson T, Liggins GC, Whittaker DJ (1988) Oxytocin stimulates the release of arachidonic acid and prostaglandin F2 alpha from human decidual cells. Prostaglandins 35:771\u2013780","journal-title":"Prostaglandins"},{"key":"1077_CR86","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1095\/biolreprod65.4.1150","volume":"65","author":"PD Burns","year":"2001","unstructured":"Burns PD, Mendes JO Jr., Yemm RS, Clay CM, Nelson SE, Hayes SH, Silvia WJ (2001) Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases. Biol Reprod 65:1150\u20135","journal-title":"Biol Reprod"},{"key":"1077_CR87","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1530\/rep.0.1260559","volume":"126","author":"KJ Sales","year":"2003","unstructured":"Sales KJ, Jabbour HN (2003) Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium. Reproduction 126:559\u201367","journal-title":"Reproduction"},{"key":"1077_CR88","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mce.2008.01.016","volume":"285","author":"KJ Sales","year":"2008","unstructured":"Sales KJ, Grant V, Jabbour HN (2008) Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. Mol Cell Endocrinol 285:51\u201361","journal-title":"Mol Cell Endocrinol"},{"key":"1077_CR89","first-page":"843","volume":"50","author":"J Shi","year":"2015","unstructured":"Shi J, Jin L, Leng J, Lang J (2015) [Response of potassium channels to estrogen and progesterone in the uterine smooth muscle cells of adenomyosis in vitro]. Zhonghua Fu Chan Ke Za Zhi 50:843\u20137","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"1077_CR90","first-page":"510","volume":"50","author":"S Wang","year":"2015","unstructured":"Wang S, Duan H, Zhang Y, Wang L, Zhang H, Li G (2015) [Mechanism of 17\u03b2-estrogen on intracellular free calcium regulation in smooth muscle cells at the endometrial-myometrial interface in uteri with adenomyosis]. Zhonghua Fu Chan Ke Za Zhi 50:510\u20135","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"1077_CR91","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1016\/j.jmig.2015.08.642","volume":"22","author":"S Wang","year":"2015","unstructured":"Wang S, Duan H (2015) Rapid effects of estrogen on intracellular Ca(2+) regulation in junctional myometrium through the menstrual cycle in uteri with and without adenomyosis. J Minim Invasive Gynecol 22:S173","journal-title":"J Minim Invasive Gynecol"},{"key":"1077_CR92","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1007\/s43032-020-00218-2","volume":"27","author":"S Wang","year":"2020","unstructured":"Wang S, Duan H, Li B (2020) Rapid effects of oestrogen on intracellular Ca(2+) in the uterine junctional myometrium of patients with and without adenomyosis in different phases of the menstrual cycle. Reprod Sci 27:1992\u20132001","journal-title":"Reprod Sci"},{"key":"1077_CR93","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.cellsig.2017.01.020","volume":"32","author":"A Ghasemi","year":"2017","unstructured":"Ghasemi A, Hashemy SI, Aghaei M, Panjehpour M (2017) RhoA\/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells. Cell Signal 32:104\u2013114","journal-title":"Cell Signal"},{"key":"1077_CR94","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/molehr\/gas019","volume":"18","author":"QY Jiang","year":"2012","unstructured":"Jiang QY, Xia JM, Ding HG, Fei XW, Lin J, Wu RJ (2012) RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis. Mol Hum Reprod 18:435\u2013441","journal-title":"Mol Hum Reprod"},{"key":"1077_CR95","first-page":"911","volume":"48","author":"S Wang","year":"2013","unstructured":"Wang S, Duan H, Zhang Y, Liu JJ (2013) [Expression of RhoA and Rho kinase in junctional zone of human adenomyosis and its relationship with dysmenorrheal]. Zhonghua Fu Chan Ke Za Zhi 48:911\u20135","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"1077_CR96","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/1933719115602764","volume":"23","author":"S Wang","year":"2016","unstructured":"Wang S, Duan H, Zhang Y, Sun FQ (2016) Abnormal activation of RhoA\/ROCK-I signaling in junctional zone smooth muscle cells of patients with adenomyosis. Reprod Sci 23:333\u2013341","journal-title":"Reprod Sci"},{"key":"1077_CR97","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1177\/1933719115584447","volume":"22","author":"FQ Sun","year":"2015","unstructured":"Sun FQ, Duan H, Wang S, Li JJ (2015) 17\u03b2-Estradiol induces overproliferation in adenomyotic human uterine smooth muscle cells of the junctional zone through hyperactivation of the Estrogen Receptor-enhanced RhoA\/ROCK signaling pathway. Reprod Sci 22:1436\u20131444","journal-title":"Reprod Sci"},{"key":"1077_CR98","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s43032-022-01036-4","volume":"30","author":"H Kobayashi","year":"2023","unstructured":"Kobayashi H (2023) Molecular targets for nonhormonal treatment based on a multistep process of adenomyosis development. Reprod Sci 30:743\u201360","journal-title":"Reprod Sci"},{"key":"1077_CR99","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/humupd\/dmt052","volume":"20","author":"G Benagiano","year":"2014","unstructured":"Benagiano G, Brosens I, Habiba M (2014) Structural and molecular features of the endomyometrium in endometriosis and adenomyosis. Hum Reprod Update 20:386\u2013402","journal-title":"Hum Reprod Update"},{"key":"1077_CR100","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1093\/humrep\/deab090","volume":"36","author":"KN Khan","year":"2021","unstructured":"Khan KN, Fujishita A, Suematsu T, Ogawa K, Koshiba A, Mori T, Itoh K, Teramukai S, Matsuda K, Nakashima M, Kitawaki J (2021) An axonemal alteration in apical endometria of human adenomyosis. Hum Reprod 36:1574\u20131589","journal-title":"Hum Reprod"},{"key":"1077_CR101","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-025-01040-1","volume":"47","author":"J Shi","year":"2025","unstructured":"Shi J, Xu Q, Yu S, Zhang T (2025) Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy. Semin Immunopathol 47:16","journal-title":"Semin Immunopathol"},{"key":"1077_CR102","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/humupd\/dmv038","volume":"21","author":"JA Maybin","year":"2015","unstructured":"Maybin JA, Critchley HO (2015) Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update 21:748\u2013761","journal-title":"Hum Reprod Update"},{"key":"1077_CR103","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0010-7824(00)00182-7","volume":"62","author":"AM Kaunitz","year":"2000","unstructured":"Kaunitz AM (2000) Menstruation: choosing whether...and when. Contraception 62:277\u201384","journal-title":"Contraception"},{"key":"1077_CR104","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/humupd\/dmv044","volume":"22","author":"S Vannuccini","year":"2016","unstructured":"Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, Petraglia F (2016) Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update 22:104\u2013115","journal-title":"Hum Reprod Update"},{"key":"1077_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tem.2014.10.003","volume":"26","author":"BD McKinnon","year":"2015","unstructured":"McKinnon BD, Bertschi D, Bersinger NA, Mueller MD (2015) Inflammation and nerve fiber interaction in endometriotic pain. Trends Endocrinol Metab 26:1\u201310","journal-title":"Trends Endocrinol Metab"},{"key":"1077_CR106","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1196\/annals.1335.032","volume":"1034","author":"G Halis","year":"2004","unstructured":"Halis G, Arici A (2004) Endometriosis and inflammation in infertility. Ann N Y Acad Sci 1034:300\u2013315","journal-title":"Ann N Y Acad Sci"},{"key":"1077_CR107","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082385","author":"YH Lin","year":"2018","unstructured":"Lin YH, Chen YH, Chang HY, Au HK, Tzeng CR, Huang YH (2018) Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19082385","journal-title":"Int J Mol Sci"},{"key":"1077_CR108","doi-asserted-by":"publisher","first-page":"166","DOI":"10.31083\/j.fbl2808166","volume":"28","author":"Q Huang","year":"2023","unstructured":"Huang Q, Yu Y, Xu W, Li S, Zhou Y, Shu J (2023) The role of peritoneal immunity in peritoneal endometriosis and related infertility. Front Biosci (Landmark Ed) 28:166","journal-title":"Front Biosci (Landmark Ed)"},{"key":"1077_CR109","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810902","author":"M Miku\u0161","year":"2022","unstructured":"Miku\u0161 M, Gold\u0161tajn M, Brle\u010di\u0107 I, Duman\u010di\u0107 S, Lagan\u00e0 AS, Chiantera V, Vuji\u0107 G, \u0106ori\u0107 M (2022) CTLA4-Linked autoimmunity in the pathogenesis of endometriosis and related infertility: a systematic review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms231810902","journal-title":"Int J Mol Sci"},{"key":"1077_CR110","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13384","volume":"85","author":"K Kolanska","year":"2021","unstructured":"Kolanska K, Alijotas-Reig J, Cohen J, Cheloufi M, Selleret L, d\u2019Argent E, Kayem G, Valverde EE, Fain O, Bornes M, Darai E, Mekinian A (2021) Endometriosis with infertility: a comprehensive review on the role of immune deregulation and immunomodulation therapy. Am J Reprod Immunol 85:e13384","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR111","first-page":"2513","volume":"22","author":"XM Wang","year":"2018","unstructured":"Wang XM, Ma ZY, Song N (2018) Inflammatory cytokines IL-6, IL-10, IL-13, TNF-\u03b1 and peritoneal fluid flora were associated with infertility in patients with endometriosis. Eur Rev Med Pharmacol Sci 22:2513\u20132518","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1077_CR112","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1093\/humrep\/dei156","volume":"20","author":"KN Khan","year":"2005","unstructured":"Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, Matsuyama T, Ishimaru T (2005) Interleukin-6- and tumour necrosis factor alpha-mediated expression of hepatocyte growth factor by stromal cells and its involvement in the growth of endometriosis. Hum Reprod 20:2715\u20132723","journal-title":"Hum Reprod"},{"key":"1077_CR113","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1177\/107155760200900208","volume":"9","author":"AM Propst","year":"2002","unstructured":"Propst AM, Quade BJ, Nowak RA, Stewart EA (2002) Granulocyte macrophage colony-stimulating factor in adenomyosis and autologous endometrium. J Soc Gynecol Investig 9:93\u201397","journal-title":"J Soc Gynecol Investig"},{"key":"1077_CR114","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194585","author":"CA Stratopoulou","year":"2021","unstructured":"Stratopoulou CA, Camboni A, Donnez J, Dolmans MM (2021) Identifying common pathogenic features in deep endometriotic nodules and uterine adenomyosis. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10194585","journal-title":"J Clin Med"},{"key":"1077_CR115","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.rbmo.2020.04.022","volume":"41","author":"B Wang","year":"2020","unstructured":"Wang B, Yang Y, Deng X, Ban Y, Chao L (2020) Interaction of M2 macrophages and endometrial cells induces downregulation of GRIM-19 in endometria of adenomyosis. Reprod Biomed Online 41:790\u2013800","journal-title":"Reprod Biomed Online"},{"key":"1077_CR116","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.rbmo.2023.01.001","volume":"46","author":"CA Stratopoulou","year":"2023","unstructured":"Stratopoulou CA, Cussac S, d\u2019Argent M, Donnez J, Dolmans MM (2023) M2 macrophages enhance endometrial cell invasiveness by promoting collective cell migration in uterine adenomyosis. Reprod Biomed Online 46:729\u201338","journal-title":"Reprod Biomed Online"},{"key":"1077_CR117","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1530\/REP-17-0174","volume":"154","author":"M An","year":"2017","unstructured":"An M, Li D, Yuan M, Li Q, Zhang L, Wang G (2017) Different macrophages equally induce EMT in endometria of adenomyosis and normal. Reproduction 154:79\u201392","journal-title":"Reproduction"},{"key":"1077_CR118","first-page":"46","volume":"96","author":"M An","year":"2017","unstructured":"An M, Li D, Yuan M, Li Q, Zhang L, Wang G (2017) Interaction of macrophages and endometrial cells induces epithelial-mesenchymal transition-like processes in adenomyosis. Biol Reprod 96:46\u201357","journal-title":"Biol Reprod"},{"key":"1077_CR119","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/biolre\/ioad015","volume":"108","author":"Y Hu","year":"2023","unstructured":"Hu Y, Yuan M, Cheng L, Wang G (2023) Extracellular vesicles contribute to EMT in adenomyosis by inducing macrophage polarization\u2020. Biol Reprod 108:584\u201396","journal-title":"Biol Reprod"},{"key":"1077_CR120","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaab053","author":"M Bourdon","year":"2021","unstructured":"Bourdon M, Santulli P, Doridot L, Jeljeli M, Ch\u00eane C, Chouzenoux S, Nicco C, Marcellin L, Chapron C, Batteux F (2021) Immune cells and Notch1 signaling appear to drive the epithelial to mesenchymal transition in the development of adenomyosis in mice. Mol Hum Reprod. https:\/\/doi.org\/10.1093\/molehr\/gaab053","journal-title":"Mol Hum Reprod"},{"key":"1077_CR121","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00011-020-01394-2","volume":"69","author":"D Ribatti","year":"2020","unstructured":"Ribatti D, Tamma R, Annese T (2020) Mast cells and angiogenesis in multiple sclerosis. Inflamm Res 69:1103\u20131110","journal-title":"Inflamm Res"},{"key":"1077_CR122","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s12016-019-08753-w","volume":"58","author":"DEA Komi","year":"2020","unstructured":"Komi DEA, Redegeld FA (2020) Role of mast cells in shaping the tumor microenvironment. Clin Rev Allergy Immunol 58:313\u2013325","journal-title":"Clin Rev Allergy Immunol"},{"key":"1077_CR123","doi-asserted-by":"publisher","first-page":"224","DOI":"10.7150\/ijms.39252","volume":"17","author":"X Che","year":"2020","unstructured":"Che X, Wang J, He J, Guo X, Li T, Zhang X (2020) The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea. Int J Med Sci 17:224\u2013233","journal-title":"Int J Med Sci"},{"key":"1077_CR124","first-page":"419","volume":"60","author":"AM Istrate-Ofi\u0163eru","year":"2019","unstructured":"Istrate-Ofi\u0163eru AM, P\u00eervan IC, Pirici D, Ro\u015fu GC, Niculescu M, Berceanu S, Manolea MM, Com\u0103nescu MV, Voicu NL, Iovan L, Vasile MM, C\u0103pit\u0103nescu RG, Di\u0163escu D, Mogoant\u0103 L, Berceanu C (2019) Triple immunohistochemistry for assessing the inflammatory, vascular and progression of adenomyosis. Rom J Morphol Embryol 60:419\u2013428","journal-title":"Rom J Morphol Embryol"},{"key":"1077_CR125","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.2147\/JIR.S402734","volume":"16","author":"W Niu","year":"2023","unstructured":"Niu W, Zhang Y, Liu H, Liang N, Xu L, Li Y, Yao W, Shi W, Liu Z (2023) Single-cell profiling uncovers the roles of endometrial fibrosis and microenvironmental changes in adenomyosis. J Inflamm Res 16:1949\u20131965","journal-title":"J Inflamm Res"},{"key":"1077_CR126","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s13046-020-01742-4","volume":"39","author":"MS Pan","year":"2020","unstructured":"Pan MS, Wang H, Ansari KH, Li XP, Sun W, Fan YZ (2020) Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway. J Exp Clin Cancer Res 39:234","journal-title":"J Exp Clin Cancer Res"},{"key":"1077_CR127","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu X, Li J, Fu M, Zhao X, Wang W (2021) The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther 6:402","journal-title":"Signal Transduct Target Ther"},{"key":"1077_CR128","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1586\/eci.11.53","volume":"7","author":"JL Herington","year":"2011","unstructured":"Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG (2011) Immune interactions in endometriosis. Expert Rev Clin Immunol 7:611\u2013626","journal-title":"Expert Rev Clin Immunol"},{"key":"1077_CR129","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1600-0625.2005.00369.x","volume":"14","author":"M Maurer","year":"2005","unstructured":"Maurer M, Metz M (2005) The status quo and quo vadis of mast cells. Exp Dermatol 14:923\u2013929","journal-title":"Exp Dermatol"},{"key":"1077_CR130","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nri2327","volume":"8","author":"SJ Galli","year":"2008","unstructured":"Galli SJ, Grimbaldeston M, Tsai M (2008) Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 8:478\u2013486","journal-title":"Nat Rev Immunol"},{"key":"1077_CR131","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/eji.201040994","volume":"41","author":"A Dudeck","year":"2011","unstructured":"Dudeck A, Suender CA, Kostka SL, von Stebut E, Maurer M (2011) Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function. Eur J Immunol 41:1883\u20131893","journal-title":"Eur J Immunol"},{"key":"1077_CR132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0897.2010.00887.x","volume":"65","author":"Y Osuga","year":"2011","unstructured":"Osuga Y, Koga K, Hirota Y, Hirata T, Yoshino O, Taketani Y (2011) Lymphocytes in endometriosis. Am J Reprod Immunol 65:1\u201310","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR133","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1093\/humrep\/der125","volume":"26","author":"A Saito","year":"2011","unstructured":"Saito A, Osuga Y, Yoshino O, Takamura M, Hirata T, Hirota Y, Koga K, Harada M, Takemura Y, Yano T, Taketani Y (2011) TGF-\u03b21 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6. Hum Reprod 26:1892\u20131898","journal-title":"Hum Reprod"},{"key":"1077_CR134","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1093\/humrep\/13.10.2910","volume":"13","author":"JN Bulmer","year":"1998","unstructured":"Bulmer JN, Jones RK, Searle RF (1998) Intraepithelial leukocytes in endometriosis and adenomyosis: comparison of eutopic and ectopic endometrium with normal endometrium. Hum Reprod 13:2910\u20132915","journal-title":"Hum Reprod"},{"key":"1077_CR135","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.mucimm.2023.02.003","volume":"16","author":"W Liu","year":"2023","unstructured":"Liu W, Sheng S, Zhu C, Li C, Zou Y, Yang C, Chen ZJ, Wang F, Jiao X (2023) Increased NKG2A(+)CD8(+) T-cell exhaustion in patients with adenomyosis. Mucosal Immunol 16:121\u2013134","journal-title":"Mucosal Immunol"},{"key":"1077_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101302","volume":"42","author":"R Tang","year":"2019","unstructured":"Tang R, Rangachari M, Kuchroo VK (2019) Tim-3: a co-receptor with diverse roles in T cell exhaustion and tolerance. Semin Immunol 42:101302","journal-title":"Semin Immunol"},{"key":"1077_CR137","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12026-014-8524-1","volume":"59","author":"JV Gorman","year":"2014","unstructured":"Gorman JV, Colgan JD (2014) Regulation of T cell responses by the receptor molecule Tim-3. Immunol Res 59:56\u201365","journal-title":"Immunol Res"},{"key":"1077_CR138","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1080\/09513590.2020.1754788","volume":"36","author":"P Huang","year":"2020","unstructured":"Huang P, Lv C, Zhang C, Feng H, Li C, Zhang H, Zhao X, Li M (2020) Expression and significance of T-cell immunoglobulin mucin molecule 3 and its ligand galectin-9 in patients with adenomyosis. Gynecol Endocrinol 36:605\u2013610","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR139","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.fertnstert.2013.10.050","volume":"101","author":"T Gui","year":"2014","unstructured":"Gui T, Chen C, Zhang Z, Tang W, Qian R, Ma X, Cao P, Wan G (2014) The disturbance of TH17-Treg cell balance in adenomyosis. Fertil Steril 101:506\u201314","journal-title":"Fertil Steril"},{"key":"1077_CR140","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.fertnstert.2006.04.034","volume":"86","author":"J-H Yang","year":"2006","unstructured":"Yang J-H, Chen M-J, Wu M-Y, Chen Y-C, Yang Y-S, Ho H-N (2006) Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis. Fertil Steril 86:1459\u20131465","journal-title":"Fertil Steril"},{"key":"1077_CR141","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1600-0897.2005.00363.x","volume":"55","author":"JH Yang","year":"2006","unstructured":"Yang JH, Wu MY, Chang DY, Chang CH, Yang YS, Ho HN (2006) Increased interleukin-6 messenger RNA expression in macrophage-cocultured endometrial stromal cells in adenomyosis. Am J Reprod Immunol 55:181\u2013187","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR142","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory t cells. Nature 441:235\u2013238","journal-title":"Nature"},{"key":"1077_CR143","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","author":"II Ivanov","year":"2006","unstructured":"Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17\u2009+\u2009t helper cells. Cell 126:1121\u20131133","journal-title":"Cell"},{"key":"1077_CR144","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.imlet.2018.10.011","volume":"201","author":"J Sikora","year":"2018","unstructured":"Sikora J, Smycz-Kuba\u0144ska M, Mielczarek-Palacz A, Bednarek I, Kondera-Anasz Z (2018) The involvement of multifunctional TGF-\u03b2 and related cytokines in pathogenesis of endometriosis. Immunol Lett 201:31\u201337","journal-title":"Immunol Lett"},{"key":"1077_CR145","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fimmu.2020.00108","volume":"11","author":"JE Miller","year":"2020","unstructured":"Miller JE, Ahn SH, Marks RM, Monsanto SP, Fazleabas AT, Koti M, Tayade C (2020) IL-17A modulates peritoneal macrophage recruitment and M2 polarization in endometriosis. Front Immunol 11:108","journal-title":"Front Immunol"},{"key":"1077_CR146","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.fertnstert.2012.07.1117","volume":"98","author":"M Takamura","year":"2012","unstructured":"Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, Hirata T, Hirota Y, Harada M, Hasegawa A, Taketani Y (2012) Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-\u03b1 (Gro-\u03b1) from endometrioma stromal cells. Fertil Steril 98:1218\u201324e1","journal-title":"Fertil Steril"},{"key":"1077_CR147","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011155","volume":"25","author":"L-T Hsu","year":"2024","unstructured":"Hsu L-T, Lu P-C, Wang Y-W, Wu H-M, Chen I-J, Huang H-Y (2024) Eutopic and ectopic endometrial interleukin-17 and interleukin-17 receptor expression at the endometrial\u2014myometrial interface in women with adenomyosis: Possible pathophysiology implications. Int J Mol Sci 25:11155","journal-title":"Int J Mol Sci"},{"key":"1077_CR148","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1093\/humrep\/deh372","volume":"19","author":"J-H Yang","year":"2004","unstructured":"Yang J-H, Chen M-J, Chen H-F, Lee T-H, Ho H-N, Yang Y-S (2004) Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis. Hum Reprod 19:1974\u20131978","journal-title":"Hum Reprod"},{"key":"1077_CR149","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.945504","volume":"13","author":"Y Chen","year":"2022","unstructured":"Chen Y, Zhu J, Chen L, Shen Y, Zhang J, Wang Q (2022) SFRP4(+)IGFBP5(hi) NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain. Front Immunol 13:945504","journal-title":"Front Immunol"},{"key":"1077_CR150","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1159\/000010137","volume":"48","author":"N Umesaki","year":"1999","unstructured":"Umesaki N, Tanaka T, Miyama M, Mizuno K, Kawamura N, Ogita S (1999) Increased natural killer cell activities in patients treated with gonadotropin releasing hormone agonist. Gynecol Obstet Invest 48:66\u201368","journal-title":"Gynecol Obstet Invest"},{"key":"1077_CR151","first-page":"279","volume":"11","author":"S Prathoomthong","year":"2018","unstructured":"Prathoomthong S, Tingthanatikul Y, Lertvikool S, Rodratn N, Waiyaput W, Dittharot K, Sroyraya M, Sophonsritsuk A (2018) The effects of Dienogest on macrophage and natural killer cells in adenomyosis: a randomized controlled study. Int J Fertil Steril 11:279\u2013286","journal-title":"Int J Fertil Steril"},{"key":"1077_CR152","first-page":"40","volume":"60","author":"MR Orazov","year":"2016","unstructured":"Orazov MR, Radzinskiy VE, Nosenko OM (2016) [The role of inflammatory and immune reactivity in developing pain in adenomyosis ]. Patol Fiziol Eksp Ter 60:40\u20134","journal-title":"Patol Fiziol Eksp Ter"},{"key":"1077_CR153","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12974-020-01752-1","volume":"17","author":"Y Wei","year":"2020","unstructured":"Wei Y, Liang Y, Lin H, Dai Y, Yao S (2020) Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation 17:80","journal-title":"J Neuroinflammation"},{"key":"1077_CR154","doi-asserted-by":"publisher","DOI":"10.3390\/biom14050583","author":"M Sreya","year":"2024","unstructured":"Sreya M, Tucker DR, Yi J, Alotaibi FT, Lee AF, Noga H, Yong PJ (2024) Nerve bundle density and expression of NGF and IL-1\u03b2 are intra-individually heterogenous in subtypes of endometriosis. Biomolecules. https:\/\/doi.org\/10.3390\/biom14050583","journal-title":"Biomolecules"},{"key":"1077_CR155","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/humupd\/dmaa038","volume":"27","author":"M Bourdon","year":"2021","unstructured":"Bourdon M, Santulli P, Jeljeli M, Vannuccini S, Marcellin L, Doridot L, Petraglia F, Batteux F, Chapron C (2021) Immunological changes associated with adenomyosis: a systematic review. Hum Reprod Update 27:108\u201329","journal-title":"Hum Reprod Update"},{"key":"1077_CR156","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3892\/etm.2023.12225","volume":"26","author":"X Jiang","year":"2023","unstructured":"Jiang X, Chen X (2023) Endometrial cell\u2013derived exosomes facilitate the development of adenomyosis via the IL\u20136\/JAK2\/STAT3 pathway. Exp Ther Med 26:526","journal-title":"Exp Ther Med"},{"key":"1077_CR157","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1093\/humrep\/deac098","volume":"37","author":"S Matsuzaki","year":"2022","unstructured":"Matsuzaki S, Pouly JL, Canis M (2022) Persistent activation of Signal Transducer And Activator Of Transcription 3 via Interleukin-6 trans-signaling is involved in fibrosis of endometriosis. Hum Reprod 37:1489\u20131504","journal-title":"Hum Reprod"},{"key":"1077_CR158","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154767","volume":"123","author":"AZ Sz\u00f3stek-Mioduchowska","year":"2019","unstructured":"Sz\u00f3stek-Mioduchowska AZ, Baclawska A, Okuda K, Skarzynski DJ (2019) Effect of proinflammatory cytokines on endometrial collagen and metallopeptidase expression during the course of equine endometrosis. Cytokine 123:154767","journal-title":"Cytokine"},{"key":"1077_CR159","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52741-1","volume":"9","author":"K Lin","year":"2019","unstructured":"Lin K, Ma J, Peng Y, Sun M, Xu K, Wu R, Lin J (2019) Autocrine production of Interleukin-34 promotes the development of endometriosis through CSF1R\/JAK3\/STAT6 signaling. Sci Rep 9:16781","journal-title":"Sci Rep"},{"key":"1077_CR160","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2005.08.053","volume":"85","author":"M Ulukus","year":"2006","unstructured":"Ulukus M, Ulukus EC, Seval Y, Cinar O, Zheng W, Arici A (2006) Expression of Interleukin-8 receptors in patients with adenomyosis. Fertil Steril 85:714\u2013720","journal-title":"Fertil Steril"},{"key":"1077_CR161","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1093\/humrep\/dei154","volume":"20","author":"EC Ulukus","year":"2005","unstructured":"Ulukus EC, Ulukus M, Seval Y, Zheng W, Arici A (2005) Expression of Interleukin-8 and Monocyte Chemotactic Protein-1 in adenomyosis. Hum Reprod 20:2958\u20132963","journal-title":"Hum Reprod"},{"key":"1077_CR162","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12622","author":"J Sikora","year":"2017","unstructured":"Sikora J, Smycz-Kuba\u0144ska M, Mielczarek-Palacz A, Kondera-Anasz Z (2017) Abnormal peritoneal regulation of chemokine activation-the role of IL-8 in pathogenesis of endometriosis. Am J Reprod Immunol. https:\/\/doi.org\/10.1111\/aji.12622","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR163","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/humrep\/det401","volume":"29","author":"GM Borrelli","year":"2014","unstructured":"Borrelli GM, Abr\u00e3o MS, Mechsner S (2014) Can chemokines be used as biomarkers for endometriosis? A systematic review. Hum Reprod 29:253\u2013266","journal-title":"Hum Reprod"},{"key":"1077_CR164","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.616696","volume":"12","author":"J Huang","year":"2021","unstructured":"Huang J, Chen X, Lv Y (2021) HMGB1 mediated inflammation and autophagy contribute to endometriosis. Front Endocrinol (Lausanne) 12:616696","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1077_CR165","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111397","volume":"127","author":"J Huang","year":"2024","unstructured":"Huang J, Chen X, Liu J (2024) High mobility group box 1 promotes endometriosis under hypoxia by regulating inflammation and autophagy in vitro and in vivo. Int Immunopharmacol 127:111397","journal-title":"Int Immunopharmacol"},{"key":"1077_CR166","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1177\/1933719117692042","volume":"24","author":"K Shimizu","year":"2017","unstructured":"Shimizu K, Kamada Y, Sakamoto A, Matsuda M, Nakatsuka M, Hiramatsu Y (2017) High expression of high-mobility group box 1 in menstrual blood: implications for endometriosis. Reprod Sci 24:1532\u20131537","journal-title":"Reprod Sci"},{"key":"1077_CR167","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2269265","volume":"39","author":"XN Liu","year":"2023","unstructured":"Liu XN, Cheng ZP (2023) Expression of high-mobility group box-1 in eutopic\/ectopic endometrium and correlations with inflammation-related factors in adenomyosis. Gynecol Endocrinol 39:2269265","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR168","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.2741\/s326","volume":"4","author":"Y Osuga","year":"2012","unstructured":"Osuga Y, Hirota Y, Yoshino O, Hirata T, Koga K, Taketani Y (2012) Proteinase-activated receptors in the endometrium and endometriosis. Front Biosci (Schol Ed) 4:1201\u20131212","journal-title":"Front Biosci (Schol Ed)"},{"key":"1077_CR169","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00210-022-02365-6","volume":"396","author":"E Irandoost","year":"2023","unstructured":"Irandoost E, Najibi S, Talebbeigi S, Nassiri S (2023) Focus on the role of NLRP3 inflammasome in the pathology of endometriosis: a review on molecular mechanisms and possible medical applications. Naunyn Schmiedebergs Arch Pharmacol 396:621\u2013631","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1077_CR170","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.rbmo.2021.10.012","volume":"44","author":"H Liu","year":"2022","unstructured":"Liu H, Zhao Y, Yang Y, Huang W, Chao L (2022) GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis. Reprod Biomed Online 44:211\u2013219","journal-title":"Reprod Biomed Online"},{"key":"1077_CR171","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104319","author":"Y Liu","year":"2024","unstructured":"Liu Y, Jiang Z, Zhang L, Tian W, Lin A, Li M (2024) Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. Reprod Biomed Online. https:\/\/doi.org\/10.1016\/j.rbmo.2024.104319","journal-title":"Reprod Biomed Online"},{"key":"1077_CR172","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12958-021-00844-8","volume":"19","author":"L Shi","year":"2021","unstructured":"Shi L, Xue X, Tian H, Ye H, Wang H, Wang R, Liu Y, Zhang C, Chen Q, Sun L (2021) WEE1 promotes endometriosis via the Wnt\/\u03b2-catenin signaling pathway. Reprod Biol Endocrinol 19:161","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR173","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1177\/1933719118806395","volume":"26","author":"M Miyashita","year":"2018","unstructured":"Miyashita M, Koga K, Takeuchi A, Makabe T, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Yoshino O, Fujii T, Osuga Y (2018) Expression of nerve injury-induced protein1 (Ninj1) in endometriosis. Reproductive Sci 26:1105\u20131110","journal-title":"Reproductive Sci"},{"key":"1077_CR174","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1177\/1933719116657192","volume":"24","author":"P Carrarelli","year":"2017","unstructured":"Carrarelli P, Yen CF, Funghi L, Arcuri F, Tosti C, Bifulco G, Luddi A, Lee CL, Petraglia F (2017) Expression of inflammatory and neurogenic mediators in adenomyosis. Reprod Sci 24:369\u2013375","journal-title":"Reprod Sci"},{"key":"1077_CR175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062313","volume":"8","author":"A Vergetaki","year":"2013","unstructured":"Vergetaki A, Jeschke U, Vrekoussis T, Taliouri E, Sabatini L, Papakonstanti EA, Makrigiannakis A (2013) Differential expression of CRH, UCN, CRHR1 and CRHR2 in eutopic and ectopic endometrium of women with endometriosis. PLoS One 8:e62313","journal-title":"PLoS One"},{"key":"1077_CR176","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/molehr\/gar020","volume":"17","author":"R Novembri","year":"2011","unstructured":"Novembri R, Carrarelli P, Toti P, Rocha AL, Borges LE, Reis FM, Piomboni P, Florio P, Petraglia F (2011) Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response. Mol Hum Reprod 17:587\u2013593","journal-title":"Mol Hum Reprod"},{"key":"1077_CR177","doi-asserted-by":"publisher","DOI":"10.3390\/biom14111402","author":"H Zhang","year":"2024","unstructured":"Zhang H, Li C, Li W, Xin W, Qin T (2024) Research advances in adenomyosis-related signaling pathways and promising targets. Biomolecules. https:\/\/doi.org\/10.3390\/biom14111402","journal-title":"Biomolecules"},{"key":"1077_CR178","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.fertnstert.2012.06.021","volume":"98","author":"R Gonz\u00e1lez-Ramos","year":"2012","unstructured":"Gonz\u00e1lez-Ramos R, Defr\u00e8re S, Devoto L (2012) Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertil Steril 98:520\u2013528","journal-title":"Fertil Steril"},{"key":"1077_CR179","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1007\/s11010-020-03986-2","volume":"476","author":"M Wu","year":"2021","unstructured":"Wu M, Zhang Y (2021) MiR-182 inhibits proliferation, migration, invasion and inflammation of endometrial stromal cells through deactivation of NF-\u03baB signaling pathway in endometriosis. Mol Cell Biochem 476:1575\u20131588","journal-title":"Mol Cell Biochem"},{"issue":"Suppl 3","key":"1077_CR180","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.fertnstert.2004.04.038","volume":"82","author":"Y Iba","year":"2004","unstructured":"Iba Y, Harada T, Horie S, Deura I, Iwabe T, Terakawa N (2004) Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression. Fertil Steril 82(Suppl 3):1036\u20131042","journal-title":"Fertil Steril"},{"key":"1077_CR181","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12631","author":"Y Azuma","year":"2017","unstructured":"Azuma Y, Taniguchi F, Nakamura K, Nagira K, Khine YM, Kiyama T, Uegaki T, Izawa M, Harada T (2017) Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway. Am J Reprod Immunol. https:\/\/doi.org\/10.1111\/aji.12631","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR182","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/humupd\/4.4.360","volume":"4","author":"H Ota","year":"1998","unstructured":"Ota H, Igarashi S, Hatazawa J, Tanaka T (1998) Is adenomyosis an immune disease? Hum Reprod Update 4:360\u2013367","journal-title":"Hum Reprod Update"},{"key":"1077_CR183","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.fertnstert.2008.02.164","volume":"91","author":"F Wang","year":"2009","unstructured":"Wang F, Li H, Yang Z, Du X, Cui M, Wen Z (2009) Expression of interleukin-10 in patients with adenomyosis. Fertil Steril 91:1681\u20131685","journal-title":"Fertil Steril"},{"key":"1077_CR184","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.biopha.2017.07.089","volume":"94","author":"T Feng","year":"2017","unstructured":"Feng T, Wei S, Wang Y, Fu X, Shi L, Qu L, Fan X (2017) Rhein ameliorates adenomyosis by inhibiting NF-\u03baB and \u03b2-Catenin signaling pathway. Biomed Pharmacother 94:231\u2013237","journal-title":"Biomed Pharmacother"},{"key":"1077_CR185","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.fertnstert.2013.04.028","volume":"100","author":"B Li","year":"2013","unstructured":"Li B, Chen M, Liu X, Guo S-W (2013) Constitutive and tumor necrosis factor-\u03b1-induced activation of nuclear factor-\u03baB in adenomyosis and its inhibition by andrographolide. Fertil Steril 100:568\u2013577","journal-title":"Fertil Steril"},{"key":"1077_CR186","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1016\/j.fertnstert.2008.05.017","volume":"91","author":"V Veillat","year":"2009","unstructured":"Veillat V, Lavoie CH, Metz CN, Roger T, Labelle Y, Akoum A (2009) Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells. Fertil Steril 91:2148\u20132156","journal-title":"Fertil Steril"},{"key":"1077_CR187","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5468\/ogs.2016.59.2.123","volume":"59","author":"H Park","year":"2016","unstructured":"Park H, Kim S-H, Cho YM, Ihm HJ, Oh YS, Hong SH, Chae HD, Kim C-H, Kang BM (2016) Increased expression of nuclear factor kappa-B p65 subunit in adenomyosis. Obstet Gynecol Sci 59:123\u2013129","journal-title":"Obstet Gynecol Sci"},{"key":"1077_CR188","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1093\/humrep\/dez252","volume":"35","author":"Q Lu","year":"2020","unstructured":"Lu Q, Huang Y, Wu J, Guan Y, Du M, Wang F, Liu Z, Zhu Y, Gong G, Hou H, Zhang M, Zhang JY, Ning F, Chen L, Wang L, Lash GE (2020) T-cadherin inhibits invasion and migration of endometrial stromal cells in endometriosis. Hum Reprod 35:145\u2013156","journal-title":"Hum Reprod"},{"key":"1077_CR189","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3109\/09513590903366988","volume":"26","author":"H Zhang","year":"2010","unstructured":"Zhang H, Li M, Wang F, Liu S, Li J, Wen Z, Zhao X (2010) Endometriotic epithelial cells induce MMPs expression in endometrial stromal cells via an NFkappaB-dependent pathway. Gynecol Endocrinol 26:456\u2013467","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR190","first-page":"227","volume":"22","author":"N Nasiri","year":"2021","unstructured":"Nasiri N, Babaei S, Moini A, Eftekhari-Yazdi P (2021) Controlling semi-invasive activity of human endometrial stromal cells by inhibiting NF-kB signaling pathway using Aloe-emodin and Aspirin. J Reprod Infertil 22:227\u2013240","journal-title":"J Reprod Infertil"},{"key":"1077_CR191","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jri.2016.08.011","volume":"118","author":"TH Lai","year":"2016","unstructured":"Lai TH, Wu PH, Wu WB (2016) Involvement of NADPH oxidase and NF-\u03baB activation in CXCL1 induction by vascular endothelial growth factor in human endometrial epithelial cells of patients with adenomyosis. J Reprod Immunol 118:61\u201369","journal-title":"J Reprod Immunol"},{"key":"1077_CR192","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3892\/ijmm.2020.4620","volume":"46","author":"X Wang","year":"2020","unstructured":"Wang X, Ren R, Shao M, Lan J (2020) MicroRNA\u201316 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor\u2013\u03baB kinase subunit \u03b2\/nuclear factor\u2013\u03baB pathway. Int J Mol Med 46:740\u2013750","journal-title":"Int J Mol Med"},{"key":"1077_CR193","doi-asserted-by":"publisher","first-page":"104213","DOI":"10.1016\/j.jri.2024.104213","volume":"162","author":"M An","year":"2024","unstructured":"An M, Fu X, Meng X, Liu H, Ma Y, Li Y, Li Q, Chen J (2024) PI3K\/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis. J Reprod Immunol 162:104213","journal-title":"J Reprod Immunol"},{"key":"1077_CR194","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103515","author":"J Zhou","year":"2020","unstructured":"Zhou J, Chern BSM, Barton-Smith P, Phoon JWL, Tan TY, Viardot-Foucault V, Ku CW, Tan HH, Chan JKY, Lee YH (2020) Peritoneal fluid cytokines reveal new insights of endometriosis subphenotypes. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21103515","journal-title":"Int J Mol Sci"},{"key":"1077_CR195","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1093\/molehr\/gaw042","volume":"22","author":"Y Jiang","year":"2016","unstructured":"Jiang Y, Jiang R, Cheng X, Zhang Q, Hu Y, Zhang H, Cao Y, Zhang M, Wang J, Ding L, Diao Z, Sun H, Yan G (2016) Decreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization. Mol Hum Reprod 22:655\u2013668","journal-title":"Mol Hum Reprod"},{"key":"1077_CR196","doi-asserted-by":"publisher","first-page":"103795","DOI":"10.1016\/j.jri.2023.103795","volume":"156","author":"N Samartzis","year":"2023","unstructured":"Samartzis N, Kalaitzopoulos DR, Noske A, Ihnenfeld I, Hutmacher J, Imesch P, Samartzis EP (2023) The immunohistochemical expression of GPER and classical sex hormone receptors differs in adenomyosis and eutopic endometrium. J Reprod Immunol 156:103795","journal-title":"J Reprod Immunol"},{"key":"1077_CR197","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.1523-1747.2003.12617.x","volume":"121","author":"N Kanda","year":"2003","unstructured":"Kanda N, Watanabe S (2003) 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. J Invest Dermatol 121:1500\u20131509","journal-title":"J Invest Dermatol"},{"key":"1077_CR198","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13058-015-0579-y","volume":"17","author":"J Yuan","year":"2015","unstructured":"Yuan J, Liu M, Yang L, Tu G, Zhu Q, Chen M, Cheng H, Luo H, Fu W, Li Z, Yang G (2015) Acquisition of epithelial-mesenchymal transition phenotype in the Tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating Tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and \u03b21-integrin signaling pathway in tumor cells. Breast Cancer Res 17:69","journal-title":"Breast Cancer Res"},{"key":"1077_CR199","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/bcr3458","volume":"15","author":"EM De Francesco","year":"2013","unstructured":"De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A, Maggiolini M (2013) HIF-1\u03b1\/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs). Breast Cancer Res 15:R64","journal-title":"Breast Cancer Res"},{"key":"1077_CR200","doi-asserted-by":"publisher","first-page":"34158","DOI":"10.18632\/oncotarget.5779","volume":"6","author":"DC Rigiracciolo","year":"2015","unstructured":"Rigiracciolo DC, Scarpelli A, Lappano R, Pisano A, Santolla MF, De Marco P, Cirillo F, Cappello AR, Dolce V, Belfiore A, Maggiolini M, De Francesco EM (2015) Copper activates HIF-1\u03b1\/GPER\/VEGF signalling in cancer cells. Oncotarget 6:34158\u201334177","journal-title":"Oncotarget"},{"key":"1077_CR201","first-page":"2218","volume":"22","author":"XY Xu","year":"2018","unstructured":"Xu XY, Zhang J, Qi YH, Kong M, Liu SA, Hu JJ (2018) Linc-ROR promotes endometrial cell proliferation by activating the PI3K-Akt pathway. Eur Rev Med Pharmacol Sci 22:2218\u20132225","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1077_CR202","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1016\/j.bbagen.2014.03.007","volume":"1840","author":"L Nissinen","year":"2014","unstructured":"Nissinen L, K\u00e4h\u00e4ri V-M (2014) Matrix metalloproteinases in inflammation. Biochim et Biophys Acta (BBA) - Gen Subj 1840:2571\u20132580","journal-title":"Biochim et Biophys Acta (BBA) - Gen Subj"},{"key":"1077_CR203","doi-asserted-by":"publisher","first-page":"14","DOI":"10.17116\/patol20188006114","volume":"80","author":"OV Zayratyants","year":"2018","unstructured":"Zayratyants OV, Adamyan LV, Manukyan LM, Kalinin DV, Arslanyan KN (2018) [The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis]. Arkh Patol 80:14\u201321","journal-title":"Arkh Patol"},{"key":"1077_CR204","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000094426","volume":"62","author":"T Li","year":"2006","unstructured":"Li T, Li YG, Pu DM (2006) Matrix metalloproteinase-2 and \u2013\u20099 expression correlated with angiogenesis in human adenomyosis. Gynecol Obstet Invest 62:229\u2013235","journal-title":"Gynecol Obstet Invest"},{"key":"1077_CR205","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0015-0282(16)55437-5","volume":"58","author":"MDEH Spuijbroek","year":"1992","unstructured":"Spuijbroek MDEH, Dunselman GAJ, Menheere PPCA, Evers JLH (1992) Early endometriosis invades the extracellular matrix. Fertil Steril 58:929\u2013933","journal-title":"Fertil Steril"},{"key":"1077_CR206","first-page":"280","volume":"25","author":"XW Zhao","year":"2008","unstructured":"Zhao XW, Li Y, Wang N, Zhao J, Li XL, Liu Q, Jia JH, Yang ZF, Kang S (2008) [Study on the association of SNPs of MMP-2 and TIMP-2 genes with the risk of endometriosis and adenomyosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:280\u20133","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"1077_CR207","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1042\/bj3051027","volume":"305","author":"E Marbaix","year":"1995","unstructured":"Marbaix E, Kokorine I, Henriet P, Donnez J, Courtoy PJ, Eeckhout Y (1995) The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation. Biochem J 305:1027\u20131030","journal-title":"Biochem J"},{"key":"1077_CR208","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.fertnstert.2014.12.124","volume":"103","author":"KW Yi","year":"2015","unstructured":"Yi KW, Kim SH, Ihm HJ, Oh YS, Chae HD, Kim CH, Kang BM (2015) Increased expression of p21-activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase-2 and \u2212\u20099 in endometrial cells. Fertil Steril 103:1089\u201397.e2","journal-title":"Fertil Steril"},{"key":"1077_CR209","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12958-015-0090-4","volume":"13","author":"M Yang","year":"2015","unstructured":"Yang M, Jiang C, Chen H, Nian Y, Bai Z, Ha C (2015) The involvement of osteopontin and matrix metalloproteinase- 9 in the migration of endometrial epithelial cells in patients with endometriosis. Reprod Biol Endocrinol 13:95","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR210","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166704","volume":"1869","author":"A Ullah","year":"2023","unstructured":"Ullah A, Wang MJ, Wang YX, Shen B (2023) CXC chemokines influence immune surveillance in immunological disorders: polycystic ovary syndrome and endometriosis. Biochim Biophys Acta Mol Basis Dis 1869:166704","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1077_CR211","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1177\/1933719118776797","volume":"26","author":"Y Peng","year":"2019","unstructured":"Peng Y, Ma J, Lin J (2019) Activation of the CXCL16\/CXCR6 axis by TNF-\u03b1 contributes to ectopic endometrial stromal cells migration and invasion. Reprod Sci 26:420\u2013427","journal-title":"Reprod Sci"},{"key":"1077_CR212","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1477-7827-5-18","volume":"5","author":"AL Chand","year":"2007","unstructured":"Chand AL, Murray AS, Jones RL, Hannan NJ, Salamonsen LA, Rombauts L (2007) Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis. Reprod Biol Endocrinol 5:18","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR213","doi-asserted-by":"publisher","first-page":"101971","DOI":"10.1016\/j.jogoh.2020.101971","volume":"50","author":"T Aksak","year":"2021","unstructured":"Aksak T, G\u00fcm\u00fcrd\u00fcl\u00fc D, \u00c7etin MT, Polat S (2021) Expression of monocyte chemotactic protein 2 and tumor necrosis factor alpha in human normal endometrium and endometriotic tissues. J Gynecol Obstet Hum Reprod 50:101971","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"1077_CR214","first-page":"754","volume":"55","author":"S Wang","year":"2020","unstructured":"Wang S, Duan H, Li BH, Wang YY, Huang JH, Guo ZC (2020) [Expression and significance of chemokine CXCL12 and receptor CXCR4 in adenomyosis]. Zhonghua fu chan ke za zhi 55:754\u2013759","journal-title":"Zhonghua fu chan ke za zhi"},{"key":"1077_CR215","first-page":"1153","volume":"29","author":"H Xu","year":"2014","unstructured":"Xu H, Yang Y, Zhou C, Huang X, Lin J, Zhang X (2014) Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis. Histol Histopathol 29:1153\u20131160","journal-title":"Histol Histopathol"},{"key":"1077_CR216","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.3892\/ol.2017.5762","volume":"13","author":"J Li","year":"2017","unstructured":"Li J, Yin G, Chen M, Yang S, Wu A, Liang J, Yuan Z (2017) Expression of CXCL12 and its receptor CXCR4 in patients with adenomyosis. Oncol Lett 13:2731\u20132736","journal-title":"Oncol Lett"},{"key":"1077_CR217","doi-asserted-by":"publisher","first-page":"102645","DOI":"10.1016\/j.jogoh.2023.102645","volume":"52","author":"A Ikebuchi","year":"2023","unstructured":"Ikebuchi A, Osaki M, Wada I, Nagata H, Nagira K, Azuma Y, Okada F, Harada T, Taniguchi F (2023) Increased chemokine ligand 26 expression and its involvement in epithelial-mesenchymal transition in the endometrium with adenomyosis. J Gynecol Obstet Hum Reprod 52:102645","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"1077_CR218","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1007\/s43032-019-00127-z","volume":"27","author":"H Qu","year":"2020","unstructured":"Qu H, Li L, Wang TL, Seckin T, Segars J, Shih IM (2020) Epithelial cells in endometriosis and adenomyosis upregulate STING expression. Reprod Sci 27:1276\u20131284","journal-title":"Reprod Sci"},{"key":"1077_CR219","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41374-021-00544-2","volume":"101","author":"X Wang","year":"2021","unstructured":"Wang X, Wei Z, Tang Z, Xue C, Yu H, Zhang D, Li Y, Liu X, Shi Y, Zhang L, Chen G, Zhou H, Wang J, Wang X (2021) IL-37b\u03941\u201345 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1\/NF-\u03baB\/MMP2 signal pathway. Lab Invest 101:760\u201374","journal-title":"Lab Invest"},{"key":"1077_CR220","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/molehr\/gaaa014","volume":"26","author":"Y He","year":"2020","unstructured":"He Y, Xiong T, Guo F, Du Z, Fan Y, Sun H, Feng Z, Zhang G (2020) Interleukin-37b inhibits the growth of murine endometriosis-like lesions by regulating proliferation, invasion, angiogenesis and inflammation. Mol Hum Reprod 26:240\u2013255","journal-title":"Mol Hum Reprod"},{"key":"1077_CR221","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/09513590.2017.1354367","volume":"34","author":"JF Jiang","year":"2018","unstructured":"Jiang JF, Xiao SS, Xue M (2018) Decreased expression of interleukin-37 in the ectopic and eutopic endometria of patients with adenomyosis. Gynecol Endocrinol 34:83\u201386","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR222","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1210\/jc.2017-01199","volume":"103","author":"SE Nematian","year":"2018","unstructured":"Nematian SE, Mamillapalli R, Kadakia TS, Majidi Zolbin M, Moustafa S, Taylor HS (2018) Systemic inflammation induced by microRNAs: endometriosis-derived alterations in circulating microRNA 125b-5p and Let-7b-5p regulate macrophage cytokine production. J Clin Endocrinol Metab 103:64\u201374","journal-title":"J Clin Endocrinol Metab"},{"key":"1077_CR223","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s11626-023-00760-8","volume":"59","author":"L Li","year":"2023","unstructured":"Li L, Ye K, Wang D (2023) Upregulation of HTRA1 mediated by the lncRNA NEAT1\/miR-141-3p axis contributes to endometriosis development through activating NLRP3 inflammasome-mediated pyroptotic cell death and cellular inflammation. In Vitro Cell Dev Biol Anim 59:166\u2013178","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"1077_CR224","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13362","volume":"85","author":"NXH Le","year":"2021","unstructured":"Le NXH, Loret de Mola JR, Bremer P, Groesch K, Wilson T, Diaz-Sylvester P, Braundmeier-Fleming AG (2021) Alteration of systemic and uterine endometrial immune populations in patients with endometriosis. Am J Reprod Immunol 85:e13362","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR225","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/REP-18-0618","volume":"158","author":"H Malvezzi","year":"2019","unstructured":"Malvezzi H, Hernandes C, Piccinato CA, Podgaec S (2019) Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis. Reproduction 158:1\u201312","journal-title":"Reproduction"},{"key":"1077_CR226","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052295","author":"I Kokot","year":"2021","unstructured":"Kokot I, Piwowar A, J\u0119dryka M, So\u0142kiewicz K, Kratz EM (2021) Diagnostic significance of selected serum inflammatory markers in women with advanced endometriosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22052295","journal-title":"Int J Mol Sci"},{"key":"1077_CR227","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cyto.2015.08.007","volume":"76","author":"J Sikora","year":"2015","unstructured":"Sikora J, Mielczarek-Palacz A, Kondera-Anasz Z, Strzelczyk J (2015) Peripheral blood proinflammatory response in women during menstrual cycle and endometriosis. Cytokine 76:117\u2013122","journal-title":"Cytokine"},{"key":"1077_CR228","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/aje\/kwx272","volume":"187","author":"F Mu","year":"2018","unstructured":"Mu F, Harris HR, Rich-Edwards JW, Hankinson SE, Rimm EB, Spiegelman D, Missmer SA (2018) A prospective study of inflammatory markers and risk of endometriosis. Am J Epidemiol 187:515\u2013522","journal-title":"Am J Epidemiol"},{"key":"1077_CR229","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1159\/000496607","volume":"84","author":"P Bellelis","year":"2019","unstructured":"Bellelis P, Frediani Barbeiro D, Gueuvoghlanian-Silva BY, Kalil J, Abr\u00e3o MS, Podgaec S (2019) Interleukin-15 and Interleukin-7 are the major cytokines to maintain endometriosis. Gynecol Obstet Invest 84:435\u201344","journal-title":"Gynecol Obstet Invest"},{"key":"1077_CR230","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043762","author":"H Kobayashi","year":"2023","unstructured":"Kobayashi H (2023) Endometrial inflammation and impaired spontaneous decidualization: insights into the pathogenesis of adenomyosis. Int J Environ Res Public Health. https:\/\/doi.org\/10.3390\/ijerph20043762","journal-title":"Int J Environ Res Public Health"},{"key":"1077_CR231","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.2147\/IJN.S354314","volume":"17","author":"L Zhang","year":"2022","unstructured":"Zhang L, Yu Z, Qu Q, Li X, Lu X, Zhang H (2022) Exosomal lncRNA HOTAIR promotes the progression and angiogenesis of endometriosis via the miR-761\/HDAC1 axis and activation of STAT3-mediated inflammation. Int J Nanomed 17:1155\u20131170","journal-title":"Int J Nanomed"},{"key":"1077_CR232","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jri.2010.11.004","volume":"88","author":"M Berbic","year":"2011","unstructured":"Berbic M, Fraser IS (2011) Regulatory T cells and other leukocytes in the pathogenesis of endometriosis. J Reprod Immunol 88:149\u2013155","journal-title":"J Reprod Immunol"},{"key":"1077_CR233","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaab036","author":"K Kusama","year":"2021","unstructured":"Kusama K, Fukushima Y, Yoshida K, Sakakibara H, Tsubata N, Yoshie M, Kojima J, Nishi H, Tamura K (2021) Endometrial epithelial-mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia. Mol Hum Reprod. https:\/\/doi.org\/10.1093\/molehr\/gaab036","journal-title":"Mol Hum Reprod"},{"key":"1077_CR234","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13298","volume":"84","author":"E Bj\u00f6rk","year":"2020","unstructured":"Bj\u00f6rk E, Vinnars MT, Nagaev I, Nagaeva O, Lundin E, Ottander U, Mincheva-Nilsson L (2020) Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity. Am J Reprod Immunol 84:e13298","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR235","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1080\/0962935031000134842","volume":"12","author":"K Szyllo","year":"2003","unstructured":"Szyllo K, Tchorzewski H, Banasik M, Glowacka E, Lewkowicz P, Kamer-Bartosinska A (2003) The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis. Mediators Inflamm 12:131\u2013138","journal-title":"Mediators Inflamm"},{"key":"1077_CR236","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13578-021-00562-z","volume":"11","author":"Z Liu","year":"2021","unstructured":"Liu Z, Sun Z, Liu H, Niu W, Wang X, Liang N, Wang X, Wang Y, Shi Y, Xu L, Shi W (2021) Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis. Cell Biosci 11:51","journal-title":"Cell Biosci"},{"key":"1077_CR237","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1016\/j.ajpath.2015.04.012","volume":"185","author":"E Greaves","year":"2015","unstructured":"Greaves E, Temp J, Esnal-Zufiurre A, Mechsner S, Horne AW, Saunders PT (2015) Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis. Am J Pathol 185:2286\u20132297","journal-title":"Am J Pathol"},{"key":"1077_CR238","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12958-018-0441-z","volume":"16","author":"Y Liang","year":"2018","unstructured":"Liang Y, Xie H, Wu J, Liu D, Yao S (2018) Villainous role of estrogen in macrophage-nerve interaction in endometriosis. Reprod Biol Endocrinol 16:122","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR239","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.fertnstert.2006.11.200","volume":"90","author":"P Montagna","year":"2008","unstructured":"Montagna P, Capellino S, Villaggio B, Remorgida V, Ragni N, Cutolo M, Ferrero S (2008) Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation. Fertil Steril 90:156\u2013164","journal-title":"Fertil Steril"},{"key":"1077_CR240","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/humrep\/dez019","volume":"34","author":"Y Gou","year":"2019","unstructured":"Gou Y, Li X, Li P, Zhang H, Xu T, Wang H, Wang B, Ma X, Jiang X, Zhang Z (2019) Estrogen receptor \u03b2 upregulates CCL2 via NF-\u03baB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis. Hum Reprod 34:646\u2013658","journal-title":"Hum Reprod"},{"key":"1077_CR241","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103090","volume":"138","author":"L-c Weng","year":"2020","unstructured":"Weng L-c, Hou S-h, Lei S-t, Peng H-y, Li M-q, Zhao D (2020) Estrogen-regulated CD200 inhibits macrophage phagocytosis in endometriosis. J Reprod Immunol 138:103090","journal-title":"J Reprod Immunol"},{"key":"1077_CR242","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.961599","volume":"13","author":"A McCallion","year":"2022","unstructured":"McCallion A, Nasirzadeh Y, Lingegowda H, Miller JE, Khalaj K, Ahn S, Monsanto SP, Bidarimath M, Sisnett DJ, Craig AW, Young SL, Lessey BA, Koti M, Tayade C (2022) Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology. Front Immunol 13:961599","journal-title":"Front Immunol"},{"key":"1077_CR243","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1177\/1933719114561559","volume":"22","author":"Y Li","year":"2015","unstructured":"Li Y, Zou S, Xia X, Zhang S (2015) Human adenomyosis endometrium stromal cells secreting more nerve growth factor: impact and effect. Reprod Sci 22:1073\u20131082","journal-title":"Reprod Sci"},{"key":"1077_CR244","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.4049\/jimmunol.162.7.4271","volume":"162","author":"JS Marshall","year":"1999","unstructured":"Marshall JS, Gomi K, Blennerhassett MG, Bienenstock J (1999) Nerve growth factor modifies the expression of inflammatory cytokines by mast cells via a prostanoid-dependent mechanism. J Immunol 162:4271\u20134276","journal-title":"J Immunol"},{"key":"1077_CR245","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1106771","volume":"14","author":"X Xu","year":"2023","unstructured":"Xu X, Wang J, Guo X, Chen Y, Ding S, Zou G, Zhu L, Li T, Zhang X (2023) GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2. Front Immunol 14:1106771","journal-title":"Front Immunol"},{"key":"1077_CR246","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1530\/REP-17-0457","volume":"155","author":"TH Zhu","year":"2018","unstructured":"Zhu TH, Ding SJ, Li TT, Zhu LB, Huang XF, Zhang XM (2018) Estrogen is an important mediator of mast cell activation in ovarian endometriomas. Reprod 155:73\u201383","journal-title":"Reprod"},{"key":"1077_CR247","doi-asserted-by":"publisher","first-page":"749979","DOI":"10.3389\/fimmu.2021.749979","volume":"12","author":"X Guo","year":"2021","unstructured":"Guo X, Xu X, Li T, Yu Q, Wang J, Chen Y, Ding S, Zhu L, Zou G, Zhang X (2021) NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis. Front Immunol 12:749979","journal-title":"Front Immunol"},{"key":"1077_CR248","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.7150\/ijbs.68224","volume":"18","author":"YY Li","year":"2022","unstructured":"Li YY, Lin YK, Li Y, Liu XH, Li DJ, Wang XL, Wang L, Zhu YZ, Yu M, Du MR (2022) SCM-198 alleviates endometriosis by suppressing Estrogen-ER\u03b1 mediated differentiation and function of CD4(+)CD25(+) regulatory T cells. Int J Biol Sci 18:1961\u20131973","journal-title":"Int J Biol Sci"},{"key":"1077_CR249","first-page":"431","volume":"6","author":"J Mei","year":"2013","unstructured":"Mei J, Li MQ, Ding D, Li DJ, Jin LP, Hu WG, Zhu XY (2013) Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway. Int J Clin Exp Pathol 6:431\u2013444","journal-title":"Int J Clin Exp Pathol"},{"key":"1077_CR250","doi-asserted-by":"publisher","first-page":"e2489","DOI":"10.1038\/cddis.2016.375","volume":"7","author":"C Wei","year":"2016","unstructured":"Wei C, Mei J, Tang L, Liu Y, Li D, Li M, Zhu X (2016) 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis. Cell Death Dis 7:e2489","journal-title":"Cell Death Dis"},{"key":"1077_CR251","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s40618-016-0435-7","volume":"39","author":"H Yang","year":"2016","unstructured":"Yang H, Yin J, Ficarrotta K, Hsu SH, Zhang W, Cheng C (2016) Aberrant expression and hormonal regulation of Galectin-3 in endometriosis women with infertility. J Endocrinol Invest 39:785\u2013791","journal-title":"J Endocrinol Invest"},{"key":"1077_CR252","doi-asserted-by":"publisher","first-page":"e13533","DOI":"10.1111\/aji.13533","volume":"87","author":"S Yamashita","year":"2022","unstructured":"Yamashita S, Hashimoto K, Sawada I, Ogawa M, Nakatsuka E, Kawano M, Kinose Y, Kodama M, Sawada K, Kimura T (2022) Endometrial galectin-3 causes endometriosis by supporting eutopic endometrial cell survival and engraftment in the peritoneal cavity. Am J Reprod Immunol 87:e13533","journal-title":"Am J Reprod Immunol"},{"key":"1077_CR253","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020230","author":"BV Hisrich","year":"2020","unstructured":"Hisrich BV, Young RB, Sansone AM, Bowens Z, Green LJ, Lessey BA, Blenda AV (2020) Role of human galectins in inflammation and cancers associated with endometriosis. Biomolecules. https:\/\/doi.org\/10.3390\/biom10020230","journal-title":"Biomolecules"},{"key":"1077_CR254","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3109\/09513590.2014.943728","volume":"30","author":"D Caserta","year":"2014","unstructured":"Caserta D, Di Benedetto L, Bordi G, D\u2019Ambrosio A, Moscarini M (2014) Levels of Galectin-3 and Stimulation Expressed Gene 2 in the peritoneal fluid of women with endometriosis: a pilot study. Gynecol Endocrinol 30:877\u2013880","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR255","doi-asserted-by":"publisher","DOI":"10.4110\/in.2023.23.e14","volume":"23","author":"YJ Kang","year":"2023","unstructured":"Kang YJ, Cho HJ, Lee Y, Park A, Kim MJ, Jeung IC, Jung YW, Jung H, Choi I, Lee HG, Yoon SR (2023) IL-17A and Th17 cells contribute to endometrial cell survival by inhibiting apoptosis and NK cell mediated cytotoxicity of endometrial cells via ERK1\/2 pathway. Immune Netw 23:e14","journal-title":"Immune Netw"},{"key":"1077_CR256","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.4049\/jimmunol.1501138","volume":"195","author":"SH Ahn","year":"2015","unstructured":"Ahn SH, Edwards AK, Singh SS, Young SL, Lessey BA, Tayade C (2015) IL-17A contributes to the pathogenesis of endometriosis by triggering proinflammatory cytokines and angiogenic growth factors. J Immunol 195:2591\u20132600","journal-title":"J Immunol"},{"key":"1077_CR257","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1210\/en.2007-0749","volume":"149","author":"T Hirata","year":"2008","unstructured":"Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y (2008) Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells. Endocrinology 149:1260\u20131267","journal-title":"Endocrinology"},{"key":"1077_CR258","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/molehr\/gah233","volume":"11","author":"M Roberts","year":"2005","unstructured":"Roberts M, Luo X, Chegini N (2005) Differential regulation of interleukins IL-13 and IL-15 by ovarian steroids, TNF-alpha and TGF-beta in human endometrial epithelial and stromal cells. Mol Hum Reprod 11:751\u2013760","journal-title":"Mol Hum Reprod"},{"key":"1077_CR259","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1530\/REP-16-0089","volume":"152","author":"JJ Yu","year":"2016","unstructured":"Yu JJ, Sun HT, Zhang ZF, Shi RX, Liu LB, Shang WQ, Wei CY, Chang KK, Shao J, Wang MY, Li MQ (2016) IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis. Reproduction 152:151\u2013160","journal-title":"Reproduction"},{"key":"1077_CR260","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1093\/humrep\/den195","volume":"23","author":"KN Khan","year":"2008","unstructured":"Khan KN, Kitajima M, Imamura T, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H (2008) Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70. Hum Reprod 23:2210\u20132219","journal-title":"Hum Reprod"},{"key":"1077_CR261","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1093\/humrep\/det280","volume":"28","author":"KN Khan","year":"2013","unstructured":"Khan KN, Kitajima M, Inoue T, Tateishi S, Fujishita A, Nakashima M, Masuzaki H (2013) Additive effects of inflammation and stress reaction on Toll-like receptor 4-mediated growth of endometriotic stromal cells. Hum Reprod 28:2794\u20132803","journal-title":"Hum Reprod"},{"key":"1077_CR262","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148165","volume":"11","author":"BH Yun","year":"2016","unstructured":"Yun BH, Chon SJ, Choi YS, Cho S, Lee BS, Seo SK (2016) Pathophysiology of endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 developing inflammation in endometrium. PLoS One 11:e0148165","journal-title":"PLoS One"},{"key":"1077_CR263","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1177\/1933719114556487","volume":"22","author":"KN Khan","year":"2015","unstructured":"Khan KN, Kitajima M, Inoue T, Fujishita A, Nakashima M, Masuzaki H (2015) 17\u03b2-estradiol and lipopolysaccharide additively promote pelvic inflammation and growth of endometriosis. Reprod Sci 22:585\u2013594","journal-title":"Reprod Sci"},{"key":"1077_CR264","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s43032-024-01766-7","volume":"32","author":"MD Dantzler","year":"2025","unstructured":"Dantzler MD, Miller TA, Dougherty MW, Quevedo A (2025) The microbiome landscape of adenomyosis: a systematic review. Reprod Sci 32:251\u2013260","journal-title":"Reprod Sci"},{"key":"1077_CR265","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/nyas.12411","volume":"1317","author":"S Ferrero","year":"2014","unstructured":"Ferrero S, Remorgida V, Maganza C, Venturini PL, Salvatore S, Papaleo E, Candiani M, Leone Roberti Maggiore U (2014) Aromatase and endometriosis: estrogens play a role. Ann N Y Acad Sci 1317:17\u201323","journal-title":"Ann N Y Acad Sci"},{"key":"1077_CR266","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0165-0378(01)00132-2","volume":"55","author":"SE Bulun","year":"2002","unstructured":"Bulun SE, Gurates B, Fang Z, Tamura M, Sebastian S, Zhou J, Amin S, Yang S (2002) Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol 55:21\u201333","journal-title":"J Reprod Immunol"},{"key":"1077_CR267","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/09513590802627647","volume":"25","author":"H Maia Jr.","year":"2009","unstructured":"Maia H Jr., Casoy J, Valente Filho J (2009) Is aromatase expression in the endometrium the cause of endometriosis and related infertility? Gynecol Endocrinol 25:253\u20137","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR268","doi-asserted-by":"publisher","first-page":"5765","DOI":"10.1210\/jcem.86.12.8082","volume":"86","author":"SJ Tsai","year":"2001","unstructured":"Tsai SJ, Wu MH, Lin CC, Sun HS, Chen HM (2001) Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 86:5765\u20135773","journal-title":"J Clin Endocrinol Metab"},{"key":"1077_CR269","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3109\/09513590.2011.588753","volume":"28","author":"K Sacco","year":"2012","unstructured":"Sacco K, Portelli M, Pollacco J, Schembri-Wismayer P, Calleja-Agius J (2012) The role of prostaglandin E2 in endometriosis. Gynecol Endocrinol 28:134\u20138","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR270","first-page":"189","volume":"68","author":"FD De Leon","year":"1986","unstructured":"De Leon FD, Vijayakumar R, Brown M, Rao CV, Yussman MA, Schultz G (1986) Peritoneal fluid volume, estrogen, progesterone, prostaglandin, and epidermal growth factor concentrations in patients with and without endometriosis. Obstet Gynecol 68:189\u2013194","journal-title":"Obstet Gynecol"},{"key":"1077_CR271","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1210\/jc.2012-3475","volume":"98","author":"Y Urata","year":"2013","unstructured":"Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S (2013) Interleukin-4 and prostaglandin E2 synergistically up-regulate 3\u03b2-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells. J Clin Endocrinol Metab 98:1583\u20131590","journal-title":"J Clin Endocrinol Metab"},{"key":"1077_CR272","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mce.2009.11.009","volume":"317","author":"H Zhang","year":"2010","unstructured":"Zhang H, Zhao X, Liu S, Li J, Wen Z, Li M (2010) 17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaB-dependent pathway. Mol Cell Endocrinol 317:31\u201343","journal-title":"Mol Cell Endocrinol"},{"key":"1077_CR273","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1093\/humupd\/dmt010","volume":"19","author":"FM Reis","year":"2013","unstructured":"Reis FM, Petraglia F, Taylor RN (2013) Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update 19:406\u2013418","journal-title":"Hum Reprod Update"},{"key":"1077_CR274","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57997-6","volume":"10","author":"Q Qi","year":"2020","unstructured":"Qi Q, Liu X, Zhang Q, Guo SW (2020) Platelets induce increased estrogen production through NF-\u03baB and TGF-\u03b21 signaling pathways in endometriotic stromal cells. Sci Rep 10:1281","journal-title":"Sci Rep"},{"key":"1077_CR275","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jog.12957","volume":"42","author":"P Chen","year":"2016","unstructured":"Chen P, Wang DB, Liang YM (2016) Evaluation of estrogen in endometriosis patients: regulation of GATA-3 in endometrial cells and effects on Th2 cytokines. J Obstet Gynaecol Res 42:669\u2013677","journal-title":"J Obstet Gynaecol Res"},{"key":"1077_CR276","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5455\/aim.2016.24.103-106","volume":"24","author":"A Sofic","year":"2016","unstructured":"Sofic A, Husic-Selimovic A, Carovac A, Jahic E, Smailbegovic V, Kupusovic J (2016) The significance of MRI evaluation of the uterine junctional zone in the early diagnosis of adenomyosis. Acta Inf Med 24:103\u2013106","journal-title":"Acta Inf Med"},{"key":"1077_CR277","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1080\/17425255.2020.1789591","volume":"16","author":"L Della Corte","year":"2020","unstructured":"Della Corte L, Barra F, Mercorio A, Evangelisti G, Rapisarda AMC, Ferrero S, Bifulco G, Giampaolino P (2020) Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis. Expert Opin Drug Metab Toxicol 16:759\u201368","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"1077_CR278","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0015-0282(00)00690-7","volume":"74","author":"HR Franke","year":"2000","unstructured":"Franke HR, van de Weijer PH, Pennings TM, van der Mooren MJ (2000) Gonadotropin-releasing hormone agonist plus \u201cadd-back\u201d hormone replacement therapy for treatment of endometriosis: a prospective, randomized, placebo-controlled, double-blind trial. Fertil Steril 74:534\u20139","journal-title":"Fertil Steril"},{"key":"1077_CR279","first-page":"403","volume":"69","author":"KA Steingold","year":"1987","unstructured":"Steingold KA, Cedars M, Lu JK, Randle D, Judd HL, Meldrum DR (1987) Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. Obstet Gynecol 69:403\u2013411","journal-title":"Obstet Gynecol"},{"key":"1077_CR280","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/humrep\/dep437","volume":"25","author":"KN Khan","year":"2010","unstructured":"Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H (2010) Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy. Hum Reprod 25:642\u2013653","journal-title":"Hum Reprod"},{"key":"1077_CR281","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1056\/NEJMoa1700089","volume":"377","author":"HS Taylor","year":"2017","unstructured":"Taylor HS, Giudice LC, Lessey BA, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K (2017) Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist. N Engl J Med 377:28\u201340","journal-title":"N Engl J Med"},{"key":"1077_CR282","first-page":"338","volume":"2","author":"O Muneyyirci-Delale","year":"2021","unstructured":"Muneyyirci-Delale O, Archer DF, Owens CD, Barnhart KT, Bradley LD, Feinberg E, Gillispie V, Hurtado S, Kim JH, Wang A, Wang H, Stewart EA (2021) Efficacy and safety of elagolix with add-back therapy in women with uterine fibroids and coexisting adenomyosis. F S Rep 2:338\u201346","journal-title":"F S Rep"},{"key":"1077_CR283","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1080\/13543784.2021.1957830","volume":"30","author":"S Dababou","year":"2021","unstructured":"Dababou S, Garzon S, Lagan\u00e0 AS, Ferrero S, Evangelisti G, Noventa M, D\u2019Alterio MN, Palomba S, Uccella S, Franchi M, Barra F (2021) Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas. Expert Opin Investig Drugs 30:903\u2013911","journal-title":"Expert Opin Investig Drugs"},{"key":"1077_CR284","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.fertnstert.2023.07.012","volume":"120","author":"J Donnez","year":"2023","unstructured":"Donnez J, Donnez O, Dolmans MM (2023) Evolution of uterine adenomyosis volume during and after GnRH antagonist (linzagolix) treatment: lessons for further clinical trials. Fertil Steril 120:1071\u20131073","journal-title":"Fertil Steril"},{"key":"1077_CR285","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.rbmo.2021.09.019","volume":"44","author":"J Donnez","year":"2022","unstructured":"Donnez J, Donnez O, Brethous M, Bestel E, Garner E, Charpentier S, Humberstone A, Loumaye E (2022) Treatment of symptomatic uterine adenomyosis with linzagolix, an oral gonadotrophin-releasing hormone antagonist: a pilot study. Reprod Biomed Online 44:200\u2013203","journal-title":"Reprod Biomed Online"},{"key":"1077_CR286","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1600-0412.2012.01350.x","volume":"91","author":"AM Badawy","year":"2012","unstructured":"Badawy AM, Elnashar AM, Mosbah AA (2012) Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: a randomized controlled trial. Acta Obstet Gynecol Scand 91:489\u2013495","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1077_CR287","doi-asserted-by":"publisher","first-page":"1468e.e9","DOI":"10.1016\/j.fertnstert.2006.09.010","volume":"87","author":"F Kimura","year":"2007","unstructured":"Kimura F, Takahashi K, Takebayashi K, Fujiwara M, Kita N, Noda Y, Harada N (2007) Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist. Fertil Steril 87:1468e.e9\u201312","journal-title":"Fertil Steril"},{"key":"1077_CR288","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1477-7827-9-88","volume":"9","author":"S Ferrero","year":"2011","unstructured":"Ferrero S, Venturini PL, Gillott DJ, Remorgida V (2011) Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial. Reprod Biol Endocrinol 9:88","journal-title":"Reprod Biol Endocrinol"},{"key":"1077_CR289","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01347-9","volume":"21","author":"P Aci\u00e9n","year":"2021","unstructured":"Aci\u00e9n P, Velasco I, Aci\u00e9n M (2021) Anastrozole and levonorgrestrel-releasing intrauterine device in the treatment of endometriosis: a randomized clinical trial. BMC Womens Health 21:211","journal-title":"BMC Womens Health"},{"key":"1077_CR290","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1530\/REP-19-0502","volume":"159","author":"DE Machado","year":"2020","unstructured":"Machado DE, Alessandra-Perini J, Menezes de Mendon\u00e7a E, Claudino MC, Nasciutti LE, Sola-Penna M, Zancan P, Alessandra Perini J (2020) Clotrimazole reduces endometriosis and the estrogen concentration by downregulating aromatase. Reproduction 159:779\u201386","journal-title":"Reproduction"},{"key":"1077_CR291","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214878","author":"CA Stratopoulou","year":"2021","unstructured":"Stratopoulou CA, Donnez J, Dolmans MM (2021) Conservative management of uterine adenomyosis: medical vs. surgical approach. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10214878","journal-title":"J Clin Med"},{"key":"1077_CR292","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3109\/09513590.2014.926882","volume":"30","author":"T Hirata","year":"2014","unstructured":"Hirata T, Izumi G, Takamura M, Saito A, Nakazawa A, Harada M, Hirota Y, Koga K, Fujii T, Osuga Y (2014) Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study. Gynecol Endocrinol 30:726\u2013729","journal-title":"Gynecol Endocrinol"},{"key":"1077_CR293","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1111\/jog.13406","volume":"43","author":"Y Osuga","year":"2017","unstructured":"Osuga Y, Watanabe M, Hagino A (2017) Long-term use of dienogest in the treatment of painful symptoms in adenomyosis. J Obstet Gynaecol Res 43:1441\u20131448","journal-title":"J Obstet Gynaecol Res"},{"key":"1077_CR294","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/jog.14209","volume":"46","author":"Y Osuga","year":"2020","unstructured":"Osuga Y, Hayashi K, Kanda S (2020) Long-term use of dienogest for the treatment of primary and secondary dysmenorrhea. J Obstet Gynaecol Res 46:606\u2013617","journal-title":"J Obstet Gynaecol Res"},{"key":"1077_CR295","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1093\/humrep\/15.5.1092","volume":"15","author":"P Stratton","year":"2000","unstructured":"Stratton P, Hartog B, Hajizadeh N, Piquion J, Sutherland D, Merino M, Lee YJ, Nieman LK (2000) A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Hum Reprod 15:1092\u20131099","journal-title":"Hum Reprod"},{"key":"1077_CR296","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.jmig.2018.04.002","volume":"25","author":"M Gracia","year":"2018","unstructured":"Gracia M, Alcal\u00e0 M, Ferreri J, Rius M, Ros C, Saco MA, Mart\u00ednez-Zamora M, Carmona F (2018) Ulipristal Acetate improves clinical symptoms in women with adenomyosis and uterine myomas. J Minim Invasive Gynecol 25:1274\u20131280","journal-title":"J Minim Invasive Gynecol"},{"key":"1077_CR297","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101978","volume":"50","author":"P Capmas","year":"2021","unstructured":"Capmas P, Brun JL, Legendre G, Koskas M, Merviel P, Fernandez H (2021) Ulipristal acetate use in adenomyosis: a randomized controlled trial. J Gynecol Obstet Hum Reprod 50:101978","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"1077_CR298","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/humupd\/dmv039","volume":"21","author":"S Iacovides","year":"2015","unstructured":"Iacovides S, Avidon I, Baker FC (2015) What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update 21:762\u2013778","journal-title":"Hum Reprod Update"},{"key":"1077_CR299","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.fertnstert.2005.05.056","volume":"84","author":"IM Spitz","year":"2005","unstructured":"Spitz IM, Grunberg SM, Chabbert-Buffet N, Lindenberg T, Gelber H, Sitruk-Ware R (2005) Management of patients receiving long-term treatment with mifepristone. Fertil Steril 84:1719\u20131726","journal-title":"Fertil Steril"},{"key":"1077_CR300","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.contraception.2007.03.005","volume":"76","author":"A Li","year":"2007","unstructured":"Li A, Felix JC, Yang W, Xiong DW, Minoo P, Jain JK (2007) Effect of mifepristone on endometrial matrix metalloproteinase expression and leukocyte abundance in new medroxyprogesterone acetate users. Contraception 76:57\u201365","journal-title":"Contraception"},{"key":"1077_CR301","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.17860","volume":"6","author":"X Che","year":"2023","unstructured":"Che X, Wang J, Sun W, He J, Wang Q, Zhu D, Zhu W, Zhang J, Dong J, Xu J, Zheng F, Zhou J, Zhao W, Lin Q, Ye L, Zhao X, Xu Z, Chen Y, Wang J, Wu W, Zhai L, Zhou Y, Zheng J, Zhang X (2023) Effect of Mifepristone vs placebo for treatment of adenomyosis with pain symptoms: a randomized clinical trial. JAMA Netw Open 6:e2317860","journal-title":"JAMA Netw Open"},{"key":"1077_CR302","doi-asserted-by":"publisher","first-page":"154","DOI":"10.12891\/ceog15872014","volume":"41","author":"Y Wang","year":"2014","unstructured":"Wang Y, Jiang X, Wang S (2014) The influence of mifepristone to caspase 3 expression in adenomyosis. Clin Exp Obstet Gynecol 41:154\u2013157","journal-title":"Clin Exp Obstet Gynecol"},{"key":"1077_CR303","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/S0002-9378(99)70120-1","volume":"181","author":"R Rivera","year":"1999","unstructured":"Rivera R, Yacobson I, Grimes D (1999) The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol 181:1263\u20131269","journal-title":"Am J Obstet Gynecol"},{"key":"1077_CR304","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2147\/IJWH.S45093","volume":"5","author":"H Maia Jr.","year":"2013","unstructured":"Maia H Jr., Haddad C, Pinheiro N, Casoy J (2013) The effect of oral contraceptives on aromatase and Cox-2 expression in the endometrium of patients with idiopathic menorrhagia or adenomyosis. Int J Womens Health 5:293\u20139","journal-title":"Int J Womens Health"},{"key":"1077_CR305","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.contraception.2015.05.015","volume":"92","author":"OM Shaaban","year":"2015","unstructured":"Shaaban OM, Ali MK, Sabra AM, Abd El Aal DE (2015) Levonorgestrel-releasing intrauterine system versus a low-dose combined oral contraceptive for treatment of adenomyotic uteri: a randomized clinical trial. Contraception 92:301\u2013307","journal-title":"Contraception"},{"key":"1077_CR306","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/ijgo.13600","volume":"154","author":"AI Hassanin","year":"2021","unstructured":"Hassanin AI, Youssef AA, Yousef AM, Ali MK (2021) Comparison of dienogest versus combined oral contraceptive pills in the treatment of women with adenomyosis: a randomized clinical trial. Int J Gynaecol Obstet 154:263\u2013269","journal-title":"Int J Gynaecol Obstet"},{"key":"1077_CR307","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2147\/DDDT.S228721","volume":"14","author":"L Du","year":"2020","unstructured":"Du L, Du DH, Chen B, Ding Y, Zhang T, Xiao W (2020) Anti-inflammatory activity of Sanjie Zhentong Capsule assessed by network pharmacology analysis of adenomyosis treatment. Drug Des Devel Ther 14:697\u2013713","journal-title":"Drug Des Devel Ther"},{"key":"1077_CR308","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/1471-0528.13785","volume":"123","author":"SY Kim","year":"2016","unstructured":"Kim SY, Koo BN, Shin CS, Ban M, Han K, Kim MD (2016) The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: a randomised controlled study. BJOG 123:580\u2013587","journal-title":"BJOG"},{"key":"1077_CR309","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00404-022-06438-y","volume":"306","author":"B Zhu","year":"2022","unstructured":"Zhu B, Chen Y, Guo M, Zhang C, Huang L, Pan Q, Lin T, Lu Y, Shen X, Zhang H (2022) Berberine attenuates hyperalgesia in mice with adenomyosis. Arch Gynecol Obstet 306:115\u2013125","journal-title":"Arch Gynecol Obstet"},{"key":"1077_CR310","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914601","author":"M Cirillo","year":"2023","unstructured":"Cirillo M, Argento FR, Becatti M, Fiorillo C, Coccia ME, Fatini C (2023) Mediterranean diet and oxidative stress: a relationship with pain perception in endometriosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241914601","journal-title":"Int J Mol Sci"},{"key":"1077_CR311","doi-asserted-by":"crossref","unstructured":"Hough B, Drever N, Manger S (2026) What is the Evidence on Lifestyle Interventions for the Symptom Management of Pelvic Pain in Women With Endometriosis or Adenomyosis? A Scoping Review. Am J Lifestyle Med : 15598276261419770","DOI":"10.1177\/15598276261419770"}],"container-title":["Seminars in Immunopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-026-01077-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00281-026-01077-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00281-026-01077-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:02:43Z","timestamp":1780934563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00281-026-01077-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":311,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1077"],"URL":"https:\/\/doi.org\/10.1007\/s00281-026-01077-w","relation":{},"ISSN":["1863-2300"],"issn-type":[{"value":"1863-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}