{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:48:21Z","timestamp":1762325301723,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00284-022-02880-y","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T10:03:59Z","timestamp":1652436239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Helicobacter pylori Infection Mediates Inflammation and Tumorigenesis-Associated Genes Through miR-155-5p: An Integrative Omics and Bioinformatics-Based Investigation"],"prefix":"10.1007","volume":"79","author":[{"given":"Ramina","family":"Mahbobi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Fallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Behmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Yadegar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojdeh","family":"Hakemi-Vala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Jafar","family":"Ehsanzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-5735","authenticated-orcid":false,"given":"Roshanak","family":"Shams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"issue":"6","key":"2880_CR1","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1086\/605443","volume":"200","author":"B Xiao","year":"2009","unstructured":"Xiao B, Liu Z, Li B-S, Tang B, Li W, Guo G et al (2009) Induction of microRNA-155 during helicobacter pylori infection and its negative regulatory role in the inflammatory response. J Infect Dis 200(6):916\u2013925","journal-title":"J Infect Dis"},{"issue":"12","key":"2880_CR2","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1002\/ijc.21731","volume":"118","author":"DM Parkin","year":"2006","unstructured":"Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118(12):3030\u20133044","journal-title":"Int J Cancer"},{"issue":"3","key":"2880_CR3","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/jcb.24389","volume":"114","author":"A Lamb","year":"2013","unstructured":"Lamb A, Chen LF (2013) Role of the Helicobacter pylori-induced inflammatory response in the development of gastric cancer. J Cell Biochem 114(3):491\u2013497","journal-title":"J Cell Biochem"},{"issue":"1","key":"2880_CR4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1053\/j.gastro.2007.05.008","volume":"133","author":"KT Wilson","year":"2007","unstructured":"Wilson KT, Crabtree JE (2007) Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133(1):288\u2013308","journal-title":"Gastroenterology"},{"key":"2880_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/481972","volume":"2015","author":"ACT Cadamuro","year":"2015","unstructured":"Cadamuro ACT, Rossi AFT, Matos Biselli-P\u00e9rico J, Fucuta Pereira P, Do Vale EPBM, Acayaba R et al (2015) Effect of Helicobacter pylori eradication on TLR2 and TLR4 expression in patients with gastric lesions. Mediators Inflammation. 2015:1\u20139","journal-title":"Mediators Inflammation."},{"key":"2880_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fimmu.2013.00109","volume":"4","author":"M Matsuura","year":"2013","unstructured":"Matsuura M (2013) Structural modifications of bacterial lipopolysaccharide that facilitate gram-negative bacteria evasion of host innate immunity. Front Immunol 4:109","journal-title":"Front Immunol"},{"key":"2880_CR7","doi-asserted-by":"publisher","DOI":"10.22631\/ajhms.2017.43225","author":"H Ghasiyari","year":"2017","unstructured":"Ghasiyari H, Rostami Nejad M, Amani D, Chaleshi V, Aghamohammadi E, Taleghani M et al (2017) Designing of specific primer pairs for quantitative analysis of TLRs (Toll-Like Receptors) genes in patients with celiac disease by polymerase chain reaction technique. Arvand J Health Med Sci. https:\/\/doi.org\/10.22631\/ajhms.2017.43225","journal-title":"Arvand J Health Med Sci"},{"issue":"2","key":"2880_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.semcancer.2008.01.005","volume":"18","author":"E Sonkoly","year":"2008","unstructured":"Sonkoly E, St\u00e5hle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Sem Cancer Biol. 18(2):131\u2013140","journal-title":"Sem Cancer Biol."},{"issue":"2","key":"2880_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S1470-2045(09)70343-2","volume":"11","author":"T Ueda","year":"2010","unstructured":"Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S et al (2010) Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol 11(2):136\u2013146","journal-title":"Lancet Oncol"},{"issue":"30","key":"2880_CR10","doi-asserted-by":"publisher","first-page":"10432","DOI":"10.3748\/wjg.v20.i30.10432","volume":"20","author":"VY Shin","year":"2014","unstructured":"Shin VY, Chu K-M (2014) MiRNA as potential biomarkers and therapeutic targets for gastric cancer. World J Gastroenterol: WJG 20(30):10432","journal-title":"World J Gastroenterol: WJG"},{"issue":"4","key":"2880_CR11","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3892\/ol.2011.313","volume":"2","author":"S Osawa","year":"2011","unstructured":"Osawa S, Shimada Y, Sekine S, Okumura T, Nagata T, Fukuoka J et al (2011) MicroRNA profiling of gastric cancer patients from formalin-fixed paraffin-embedded samples. Oncol Lett 2(4):613\u2013619","journal-title":"Oncol Lett"},{"issue":"10","key":"2880_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.14715\/cmb\/2017.63.10.16","volume":"63","author":"R Shamsi","year":"2017","unstructured":"Shamsi R, Seifi-Alan M, Behmanesh A, Omrani M, Mirfakhraie R, Ghafouri-Fard S (2017) A bioinformatics approach for identification of miR-100 targets implicated in breast cancer. Cell Mol Biol 63(10):99\u2013105","journal-title":"Cell Mol Biol"},{"key":"2880_CR13","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.2147\/CMAR.S245872","volume":"12","author":"R Shams","year":"2020","unstructured":"Shams R, Aghdaei HA, Behmanesh A, Sadeghi A, Zali M, Salari S et al (2020) MicroRNAs targeting MYC expression: trace of hope for pancreatic cancer therapy: a systematic review. Cancer Manage Res 12:2393","journal-title":"Cancer Manage Res"},{"issue":"8","key":"2880_CR14","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.febslet.2010.02.063","volume":"584","author":"B Tang","year":"2010","unstructured":"Tang B, Xiao B, Liu Z, Li N, Zhu E-D, Li B-S et al (2010) Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett 584(8):1481\u20131486","journal-title":"FEBS Lett"},{"issue":"4","key":"2880_CR15","first-page":"607","volume":"19","author":"S Cheng","year":"2015","unstructured":"Cheng S, Li L, Wang L (2015) miR-155 and miR-146b negatively regulates IL6 in Helicobacter pylori (cagA+) infected gastroduodenal ulcer. Eur Rev Med Pharmacol Sci 19(4):607\u2013613","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"11","key":"2880_CR16","doi-asserted-by":"publisher","first-page":"e47396","DOI":"10.1371\/journal.pone.0047396","volume":"7","author":"Y Saito","year":"2012","unstructured":"Saito Y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, Hirata K et al (2012) Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. PLoS ONE 7(11):e47396","journal-title":"PLoS ONE"},{"key":"2880_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-1-4939-3578-9_5","volume-title":"Statistical genomics","author":"E Clough","year":"2016","unstructured":"Clough E, Barrett T (2016) The gene expression omnibus database. In: Math\u00e9 E, Davis S (eds) Statistical genomics. Springer, NY, pp 93\u2013110"},{"issue":"10","key":"2880_CR18","doi-asserted-by":"publisher","first-page":"e0206239","DOI":"10.1371\/journal.pone.0206239","volume":"13","author":"C Sticht","year":"2018","unstructured":"Sticht C, De La Torre C, Parveen A, Gretz N (2018) miRWalk: An online resource for prediction of microRNA binding sites. PLoS ONE 13(10):e0206239","journal-title":"PLoS ONE"},{"issue":"9","key":"2880_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2003-4-9-r60","volume":"4","author":"G Dennis","year":"2003","unstructured":"Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC et al (2003) DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4(9):1\u201311","journal-title":"Genome Biol"},{"issue":"W1","key":"2880_CR20","doi-asserted-by":"publisher","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","volume":"48","author":"L Chang","year":"2020","unstructured":"Chang L, Zhou G, Soufan O, Xia J (2020) miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology. Nucleic Acids Res 48(W1):W244\u2013W251","journal-title":"Nucleic Acids Res"},{"key":"2880_CR21","first-page":"401","volume":"5","author":"M Goldman","year":"2018","unstructured":"Goldman M, Craft B, Brooks A, Zhu J, Haussler D (2018) The UCSC Xena Platform for cancer genomics data visualization and interpretation. BioRxiv. 5:401","journal-title":"BioRxiv."},{"key":"2880_CR22","first-page":"337","volume":"4","author":"W-J Ni","year":"2015","unstructured":"Ni W-J, Leng X-M (2015) Dynamic miRNA\u2013mRNA paradigms: New faces of miRNAs. Biochem Biophys Rep 4:337\u2013341","journal-title":"Biochem Biophys Rep"},{"key":"2880_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01197","author":"L Tribolet","year":"2020","unstructured":"Tribolet L, Kerr E, Cowled C, Bean AG, Stewart CR, Dearnley M et al (2020) MicroRNA biomarkers for infectious diseases: from basic research to biosensing. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2020.01197","journal-title":"Front Microbiol"},{"issue":"5","key":"2880_CR24","first-page":"4545","volume":"8","author":"Y Yao","year":"2015","unstructured":"Yao Y, Li G, Wu J, Zhang X, Wang J (2015) Inflammatory response of macrophages cultured with Helicobacter pylori strains was regulated by miR-155. Int J Clin Exp Pathol 8(5):4545","journal-title":"Int J Clin Exp Pathol"},{"issue":"10","key":"2880_CR25","doi-asserted-by":"publisher","first-page":"894","DOI":"10.18632\/oncotarget.27520","volume":"11","author":"C Prinz","year":"2020","unstructured":"Prinz C, Weber D (2020) MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric inflammation and cancer development: critical importance of miR-155. Oncotarget 11(10):894","journal-title":"Oncotarget"},{"issue":"2","key":"2880_CR26","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1038\/emm.2013.28","volume":"45","author":"MA Anwar","year":"2013","unstructured":"Anwar MA, Basith S, Choi S (2013) Negative regulatory approaches to the attenuation of Toll-like receptor signaling. Exp Mol Med 45(2):e11\u2013e11","journal-title":"Exp Mol Med"},{"issue":"6","key":"2880_CR27","first-page":"1960","volume":"27","author":"C-L Li","year":"2012","unstructured":"Li C-L, Nie H, Wang M, Su L-P, Li J-F, Yu Y-Y et al (2012) microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep 27(6):1960\u20131966","journal-title":"Oncol Rep"},{"issue":"6","key":"2880_CR28","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s00432-016-2139-y","volume":"142","author":"Z Ma","year":"2016","unstructured":"Ma Z, Ma Y, Xia Q, Li Y, Li R, Chang W et al (2016) MicroRNA-155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1. J Cancer Res Clin Oncol 142(6):1201\u20131212","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"2880_CR29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","volume":"3","author":"SF Moss","year":"2017","unstructured":"Moss SF (2017) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183\u2013191","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2880_CR30","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.3389\/fimmu.2018.02316","volume":"9","author":"C Brosseau","year":"2018","unstructured":"Brosseau C, Colas L, Magnan A, Brouard S (2018) CD9 tetraspanin: a new pathway for the regulation of inflammation? Front Immunol 9:2316","journal-title":"Front Immunol"},{"issue":"5","key":"2880_CR31","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.4049\/jimmunol.175.5.2925","volume":"175","author":"A Cariappa","year":"2005","unstructured":"Cariappa A, Shoham T, Liu H, Levy S, Boucheix C, Pillai S (2005) The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity. J Immunol 175(5):2925\u20132930","journal-title":"J Immunol"},{"issue":"2","key":"2880_CR32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1042\/BST0390547","volume":"39","author":"H-X Wang","year":"2011","unstructured":"Wang H-X, Li Q, Sharma C, Knoblich K, Hemler ME (2011) Tetraspanin protein contributions to cancer. Biochem Soc Trans 39(2):547\u2013552","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"2880_CR33","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1128\/IAI.01354-10","volume":"79","author":"LR Green","year":"2011","unstructured":"Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR, Read RC (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells. Infect Immun 79(6):2241\u20132249","journal-title":"Infect Immun"},{"issue":"2","key":"2880_CR34","first-page":"1999","volume":"15","author":"N Erin","year":"2018","unstructured":"Erin N, T\u00fcrker S, Elpek \u00d6, Yildirim B (2018) ADAM proteases involved in inflammation are differentially altered in patients with gastritis or ulcer. Exp Ther Med 15(2):1999\u20132005","journal-title":"Exp Ther Med"},{"issue":"2","key":"2880_CR35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.biochi.2007.08.008","volume":"90","author":"N Rocks","year":"2008","unstructured":"Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gu\u00e9ders M et al (2008) Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie 90(2):369\u2013379","journal-title":"Biochimie"},{"issue":"9","key":"2880_CR36","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1084\/jem.20151095","volume":"213","author":"L Atapattu","year":"2016","unstructured":"Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME et al (2016) An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth targeted inhibition of active ADAM10 in tumors. J Exp Med 213(9):1741\u20131757","journal-title":"J Exp Med"},{"issue":"9","key":"2880_CR37","doi-asserted-by":"publisher","first-page":"e258","DOI":"10.1038\/emm.2016.79","volume":"48","author":"D Chanda","year":"2016","unstructured":"Chanda D, Li J, Oligschlaeger Y, Jeurissen ML, Houben T, Walenbergh SM et al (2016) MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Exp Mol medicine. 48(9):e258","journal-title":"Exp Mol medicine."},{"issue":"6","key":"2880_CR38","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1046\/j.1365-3083.2002.01177.x","volume":"56","author":"MH Wang","year":"2002","unstructured":"Wang MH, Zhou YQ, Chen YQ (2002) Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities. Scand J Immunol 56(6):545\u2013553","journal-title":"Scand J Immunol"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-022-02880-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-022-02880-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-022-02880-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T10:07:55Z","timestamp":1656324475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-022-02880-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["2880"],"URL":"https:\/\/doi.org\/10.1007\/s00284-022-02880-y","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"type":"print","value":"0343-8651"},{"type":"electronic","value":"1432-0991"}],"subject":[],"published":{"date-parts":[[2022,5,13]]},"assertion":[{"value":"14 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not associated.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"NA.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"NA.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publication"}}],"article-number":"192"}}