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The aims of this study were to ascertain the prevalence of biofilm-forming bacteria responsible for causing clinical mastitis in dairy herds and to assess the effectiveness of bacteriocins, produced by <jats:italic>Bacillus subtilis<\/jats:italic>, in controlling the growth of these bacteria in the milk of animals. A total of 150 milk samples were collected from cows and buffalos suffering from mastitis and the etiological agents were isolated and identified by the VITEK-2-COMPACT-SYSTEM\u00ae. Additionally, the capability of the bacterial isolates to produce biofilms was determined. RT-PCR was used to detect enterotoxin-producing genes (<jats:italic>sed<\/jats:italic> and <jats:italic>seb<\/jats:italic>), resistance genes (<jats:italic>mecA<\/jats:italic> and <jats:italic>blaZ<\/jats:italic>), and biofilm-associated genes (<jats:italic>icaA<\/jats:italic> and <jats:italic>fnbA<\/jats:italic>) in the isolated bacteria. The susceptibility patterns of the bacterial isolates to bacteriocins were assessed using an agar well-diffusion assay. <jats:italic>S. aureus<\/jats:italic> was significantly more capable of producing biofilms than coagulase-negative <jats:italic>Staphylococcus<\/jats:italic> isolates. <jats:italic>S. ubris<\/jats:italic> was the strongest biofilm producer among the <jats:italic>Streptococcus<\/jats:italic> species. The sensitivity profiles of the <jats:italic>Staphylococcus<\/jats:italic> spp. (<jats:italic>S. aureus<\/jats:italic> and coagulase-negative <jats:italic>Staphylococcus<\/jats:italic>) and their biofilm producers to bacteriocins were significantly higher (100% and 90%, respectively) at the same concentration. Bacteriocins had a lethal effect on <jats:italic>Staphylococci<\/jats:italic>, <jats:italic>Streptococci<\/jats:italic>, and biofilm development at a dose of 250\u00a0\u00b5g\/mL. In dairy farms, bacteriocins are a viable alternative treatment for the prevention and control of bovine clinical mastitis.<\/jats:p>","DOI":"10.1007\/s00284-023-03324-x","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T07:02:27Z","timestamp":1685516547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Efficacy of Bacteriocins Against Biofilm-Producing Bacteria Causing Bovine Clinical Mastitis in Dairy Farms: A New Strategy"],"prefix":"10.1007","volume":"80","author":[{"given":"Ismail","family":"Raheel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa N.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Abdrabo","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"3324_CR1","doi-asserted-by":"publisher","first-page":"10381","DOI":"10.3168\/jds.2017-13023","volume":"100","author":"PL Ruegg","year":"2017","unstructured":"Ruegg PL (2017) A 100-year review: mastitis detection, management, and prevention. 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