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Chitosan is studied because of its appealing properties and diverse applications. The purpose of this work is to synthesize chitosan nanoparticles (CSNPs) by ionic gelation method at various pH levels and test them against Mucor and other filamentous fungus. Field Emission Scanning Electron Microscope, Zeta sizer, Zeta potential, and Fourier Transformed Infrared Spectroscopy were used to characterize CSNPs. Hydrodynamic size increased considerably with increasing pH. Our CSNPs were tested against fungal isolates of <jats:italic>Aspergillus Flavus RCMB 02783, Aspergillus Fumigatus RCMB 02564<\/jats:italic>, and <jats:italic>Aspergillus Niger RCMB 02588, Penicillium Notatum (NCPF 2881)<\/jats:italic> and \u00a0 (<jats:italic>M. circinelloides<\/jats:italic> CNRMA 03.894)\u00a0<jats:italic>causing mucromycosis<\/jats:italic>. Antifungal activity was investigated using Minimum inhibitory concentration (MIC), Minimum Fungicidal concentration\u00a0(MFC), Disc diffusion assay,\u00a0and Antifungal inhibitory percentages methods. The best antifungal efficacy results were obtained through CSNPs prepared at pH\u2009=\u20094.4 at very low concentration for MIC (1.03 or 2.75\u00a0\u03bcg\/mL) with 100% <jats:italic>M. circinelloides<\/jats:italic>\u00a0inhibition followed by pH\u2009=\u20094.6 with MIC (73 or 208\u00a0\u03bcg\/mL) and 93% \u00a0<jats:italic>M. cirecinelloides<\/jats:italic> inhibition %. Future usage of these materials in masks or wound dressing to avoid fungal infections, including mucormycosis following COVID-19, penicillium, and aspergillosis toxicity and infections.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00284-023-03555-y","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T19:02:03Z","timestamp":1703271723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Antifungal Activity of Chitosan Polymeric Nanoparticles and Correlation with Their pH Against Mucor circinelloides Causing Mucormycosis, Along with Penicillium notatum and Aspergillus Species"],"prefix":"10.1007","volume":"81","author":[{"given":"Fatma I.","family":"Abo El-Ela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid Hamdy","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa M.","family":"Amer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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