{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:43:02Z","timestamp":1790991782335,"version":"4.1.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00284-025-04091-7","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T13:38:36Z","timestamp":1738762716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Harnessing Cyclic di-GMP Signaling: A Strategic Approach to Combat Bacterial Biofilm-Associated Chronic Infections"],"prefix":"10.1007","volume":"82","author":[{"given":"P.","family":"Snega Priya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramu","family":"Meenatchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Pasupuleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-1905","authenticated-orcid":false,"given":"S. Karthick Raja","family":"Namasivayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"4091_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nature.2014.15135","author":"S Reardon","year":"2014","unstructured":"Reardon S (2014) WHO warns against \u201cpost-antibiotic\u201d era. Nature. https:\/\/doi.org\/10.1038\/nature.2014.15135","journal-title":"Nature"},{"key":"4091_CR2","unstructured":"O\u2019Neill J (2018) Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev Antimicrob Resist. 2014"},{"key":"4091_CR3","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJ Murray","year":"2022","unstructured":"Murray CJ, Ikuta KS, Sharara F et al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399:629\u2013655. https:\/\/doi.org\/10.1016\/S0140-6736(21)02724-0","journal-title":"Lancet"},{"key":"4091_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.15698\/mic2023.11.807","volume":"10","author":"S Yang","year":"2023","unstructured":"Yang S, Li X, Cang W et al (2023) Biofilm tolerance, resistance and infections increasing threat of public health. Microb Cell 10:233\u2013247. https:\/\/doi.org\/10.15698\/mic2023.11.807","journal-title":"Microb Cell"},{"key":"4091_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2024.100231","author":"L Kadirvelu","year":"2024","unstructured":"Kadirvelu L, Sivaramalingam SS, Jothivel D et al (2024) A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants. Curr Res Microb Sci. https:\/\/doi.org\/10.1016\/j.crmicr.2024.100231","journal-title":"Curr Res Microb Sci"},{"key":"4091_CR6","doi-asserted-by":"publisher","first-page":"106387","DOI":"10.1016\/j.micpath.2023.106387","volume":"184","author":"S Boopathi","year":"2023","unstructured":"Boopathi S, Priya PS, Kesavan D et al (2023) Unveiling nanotubes-mediated communication: Enterococcus faecalis countering Salmonella ser. Typhi\u2014in vitro and in vivo insights. Microb Pathog 184:106387. https:\/\/doi.org\/10.1016\/j.micpath.2023.106387","journal-title":"Microb Pathog"},{"key":"4091_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00043-12","volume":"77","author":"U R\u00f6mling","year":"2013","unstructured":"R\u00f6mling U, Galperin MY, Gomelsky M (2013) Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol Mol Biol Rev 77:1\u201352","journal-title":"Microbiol Mol Biol Rev"},{"key":"4091_CR8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.mib.2006.02.010","volume":"9","author":"U R\u00f6mling","year":"2006","unstructured":"R\u00f6mling U, Amikam D (2006) Cyclic di-GMP as a second messenger. Curr Opin Microbiol 9:218\u2013228","journal-title":"Curr Opin Microbiol"},{"key":"4091_CR9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/325279a0","volume":"325","author":"P Ross","year":"1987","unstructured":"Ross P, Weinhouse H, Aloni Y et al (1987) Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid. Nature 325:279\u2013281","journal-title":"Nature"},{"key":"4091_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/1040841X.2022.2154140","volume":"50","author":"Q Feng","year":"2024","unstructured":"Feng Q, Zhou J, Zhang L et al (2024) Insights into the molecular basis of c-di-GMP signaling in Pseudomonas aeruginosa. Crit Rev Microbiol 50:20\u201338. https:\/\/doi.org\/10.1080\/1040841X.2022.2154140","journal-title":"Crit Rev Microbiol"},{"key":"4091_CR11","doi-asserted-by":"publisher","first-page":"10738","DOI":"10.1038\/s41598-018-29121-2","volume":"8","author":"D Fleming","year":"2018","unstructured":"Fleming D, Rumbaugh K (2018) The consequences of biofilm dispersal on the host. Sci Rep 8:10738. https:\/\/doi.org\/10.1038\/s41598-018-29121-2","journal-title":"Sci Rep"},{"key":"4091_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01454","author":"R Garc\u00eda-Contreras","year":"2016","unstructured":"Garc\u00eda-Contreras R (2016) Is quorum sensing interference a viable alternative to treat pseudomonas aeruginosa infections? Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2016.01454","journal-title":"Front Microbiol"},{"key":"4091_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s12275-024-00103-6","volume":"62","author":"SPRR Nayak","year":"2024","unstructured":"Nayak SPRR, Basty C, Boopathi S et al (2024) Furan-based chalcone annihilates the multi-drug-resistant Pseudomonas aeruginosa and protects zebra fish against its infection. J Microbiol 62:75\u201389. https:\/\/doi.org\/10.1007\/s12275-024-00103-6","journal-title":"J Microbiol"},{"key":"4091_CR14","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.2147\/IDR.S403441","volume":"16","author":"SM Ghanem","year":"2023","unstructured":"Ghanem SM, Abd El-Baky RM, Abourehab MA et al (2023) Prevalence of quorum sensing and virulence factor genes among pseudomonas aeruginosa isolated from patients suffering from different infections and their association with antimicrobial resistance. Infect Drug Resist 16:2371\u20132385. https:\/\/doi.org\/10.2147\/IDR.S403441","journal-title":"Infect Drug Resist"},{"key":"4091_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12088-015-0558-0","volume":"56","author":"S Koul","year":"2016","unstructured":"Koul S, Prakash J, Mishra A, Kalia VC (2016) Potential emergence of multi-quorum sensing inhibitor resistant (MQSIR) bacteria. Indian J Microbiol 56:1\u201318. https:\/\/doi.org\/10.1007\/s12088-015-0558-0","journal-title":"Indian J Microbiol"},{"key":"4091_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/tqem.22270","author":"L Fa","year":"2024","unstructured":"Fa L, Namasivayam SKR (2024) Combatting microbial biofouling network associated with Chembarambakkam Lake water using Acalypha indica derived metabolites. Environ Qual Manag. https:\/\/doi.org\/10.1002\/tqem.22270","journal-title":"Environ Qual Manag"},{"key":"4091_CR17","doi-asserted-by":"publisher","first-page":"112856","DOI":"10.1016\/j.intimp.2024.112856","volume":"140","author":"K Kandaswamy","year":"2024","unstructured":"Kandaswamy K, Prasad Panda S, Subramanian R et al (2024) Synergistic berberine chloride and curcumin-loaded nanofiber therapies against methicillin-resistant Staphylococcus aureus infection: augmented immune and inflammatory responses in zebrafish wound healing. Int Immunopharmacol 140:112856. https:\/\/doi.org\/10.1016\/j.intimp.2024.112856","journal-title":"Int Immunopharmacol"},{"key":"4091_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3390\/life13010172","volume":"13","author":"S Mishra","year":"2023","unstructured":"Mishra S, Gupta A, Upadhye V et al (2023) Therapeutic Strategies against Biofilm Infections. Life 13:172. https:\/\/doi.org\/10.3390\/life13010172","journal-title":"Life"},{"key":"4091_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00043-12","volume":"77","author":"U R\u00f6mling","year":"2013","unstructured":"R\u00f6mling U, Galperin MY, Gomelsky M (2013) The Anabaena sp. strain PCC 7120 gene all2874 encodes a diguanylate cyclase and is required for normal heterocyst development under high-light growth conditions. Microbiol Mol Biol Rev 77:1\u201352","journal-title":"Microbiol Mol Biol Rev"},{"key":"4091_CR20","doi-asserted-by":"publisher","first-page":"100129","DOI":"10.1016\/j.bioflm.2023.100129","volume":"5","author":"M Fern\u00e1ndez-Bill\u00f3n","year":"2023","unstructured":"Fern\u00e1ndez-Bill\u00f3n M, Llamb\u00edas-Cabot AE, Jordana-Lluch E et al (2023) Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms. Biofilm 5:100129. https:\/\/doi.org\/10.1016\/j.bioflm.2023.100129","journal-title":"Biofilm"},{"key":"4091_CR21","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1038\/s41467-024-46149-3","volume":"15","author":"X Zhan","year":"2024","unstructured":"Zhan X, Zhang K, Wang C et al (2024) A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun 15:1860. https:\/\/doi.org\/10.1038\/s41467-024-46149-3","journal-title":"Nat Commun"},{"key":"4091_CR22","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1080\/1040841X.2022.2062219","volume":"49","author":"RC Costa","year":"2023","unstructured":"Costa RC, Bertolini M, Costa Oliveira BE et al (2023) Polymicrobial biofilms related to dental implant diseases: unravelling the critical role of extracellular biofilm matrix. Crit Rev Microbiol 49:370\u2013390. https:\/\/doi.org\/10.1080\/1040841X.2022.2062219","journal-title":"Crit Rev Microbiol"},{"key":"4091_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4161\/viru.23987","volume":"4","author":"SS Grant","year":"2013","unstructured":"Grant SS, Hung DT (2013) Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence 4:273\u2013283. https:\/\/doi.org\/10.4161\/viru.23987","journal-title":"Virulence"},{"key":"4091_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.7150\/jbji.28508","volume":"3","author":"A Sousa","year":"2018","unstructured":"Sousa A, Carvalho A, Pereira C et al (2018) Economic impact of prosthetic joint infection\u2014an evaluation within the Portuguese national health system. J Bone Jt Infect 3:197\u2013202. https:\/\/doi.org\/10.7150\/jbji.28508","journal-title":"J Bone Jt Infect"},{"key":"4091_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/14787210.2018.1417036","volume":"16","author":"JL Del Pozo","year":"2018","unstructured":"Del Pozo JL (2018) Biofilm-related disease. Expert Rev Anti Infect Ther 16:51\u201365. https:\/\/doi.org\/10.1080\/14787210.2018.1417036","journal-title":"Expert Rev Anti Infect Ther"},{"key":"4091_CR26","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1574-695X.2010.00714.x","volume":"59","author":"M Burm\u00f8lle","year":"2010","unstructured":"Burm\u00f8lle M, Thomsen TR, Fazli M et al (2010) Biofilms in chronic infections\u2014a matter of opportunity\u2014monospecies biofilms in multispecies infections. FEMS Immunol Med Microbiol 59:324\u2013336. https:\/\/doi.org\/10.1111\/j.1574-695X.2010.00714.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"4091_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.641920","author":"J Qu","year":"2021","unstructured":"Qu J, Cai Z, Liu Y et al (2021) Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2021.641920","journal-title":"Front Cell Infect Microbiol"},{"key":"4091_CR28","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1136\/thoraxjnl-2021-217576","volume":"77","author":"M Kolpen","year":"2022","unstructured":"Kolpen M, Kragh KN, Enciso JB et al (2022) Bacterial biofilms predominate in both acute and chronic human lung infections. Thorax 77:1015\u20131022. https:\/\/doi.org\/10.1136\/thoraxjnl-2021-217576","journal-title":"Thorax"},{"key":"4091_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/mmi.15113","volume":"120","author":"F Liu","year":"2023","unstructured":"Liu F, Wang F, Yuan Y et al (2023) Quorum sensing signal synthases enhance Vibrio parahaemolyticus swarming motility. Mol Microbiol 120:241\u2013257. https:\/\/doi.org\/10.1111\/mmi.15113","journal-title":"Mol Microbiol"},{"key":"4091_CR30","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1111\/raq.12774","volume":"15","author":"PS Priya","year":"2023","unstructured":"Priya PS, Boopathi S, Murugan R et al (2023) Quorum sensing signals: Aquaculture risk factor. Rev Aquac 15:1294\u20131310. https:\/\/doi.org\/10.1111\/raq.12774","journal-title":"Rev Aquac"},{"key":"4091_CR31","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1369-5274(99)00025-9","volume":"2","author":"BL Bassler","year":"1999","unstructured":"Bassler BL (1999) How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol 2:582\u2013587","journal-title":"Curr Opin Microbiol"},{"key":"4091_CR32","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41579-021-00557-0","volume":"19","author":"KL Visick","year":"2021","unstructured":"Visick KL, Stabb EV, Ruby EG (2021) A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host. Nat Rev Microbiol 19:654\u2013665. https:\/\/doi.org\/10.1038\/s41579-021-00557-0","journal-title":"Nat Rev Microbiol"},{"key":"4091_CR33","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1073\/pnas.81.13.4154","volume":"81","author":"J Engebrecht","year":"1984","unstructured":"Engebrecht J, Silverman M (1984) Identification of genes and gene products necessary for bacterial bioluminescence. Proc Natl Acad Sci 81:4154\u20134158","journal-title":"Proc Natl Acad Sci"},{"key":"4091_CR34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","volume":"21","author":"CM Waters","year":"2005","unstructured":"Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21:319\u2013346","journal-title":"Annu Rev Cell Dev Biol"},{"key":"4091_CR35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/MMBR.00046-12","volume":"77","author":"B LaSarre","year":"2013","unstructured":"LaSarre B, Federle MJ (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77:73\u2013111","journal-title":"Microbiol Mol Biol Rev"},{"key":"4091_CR36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","volume":"55","author":"MB Miller","year":"2001","unstructured":"Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55:165\u2013199","journal-title":"Annu Rev Microbiol"},{"key":"4091_CR37","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/genes11101209","volume":"11","author":"E Piattelli","year":"2020","unstructured":"Piattelli E, Peltier J, Soutourina O (2020) Interplay between regulatory RNAs and signal transduction systems during bacterial infection. Genes 11:1209. https:\/\/doi.org\/10.3390\/genes11101209","journal-title":"Genes"},{"key":"4091_CR38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/B978-0-12-817193-6.00002-9","volume-title":"RNA-based regulation in human health and disease","author":"SC Lakhotia","year":"2020","unstructured":"Lakhotia SC, Mallick B, Roy J (2020) Non-coding RNAs: ever-expanding diversity of types and functions. RNA-based regulation in human health and disease. Elsevier, pp 5\u201357"},{"key":"4091_CR39","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3390\/antibiotics11091243","volume":"11","author":"N Giarimoglou","year":"2022","unstructured":"Giarimoglou N, Kouvela A, Maniatis A et al (2022) A riboswitch-driven era of new antibacterials. Antibiotics 11:1243. https:\/\/doi.org\/10.3390\/antibiotics11091243","journal-title":"Antibiotics"},{"key":"4091_CR40","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1128\/JB.01253-09","volume":"192","author":"F Tao","year":"2010","unstructured":"Tao F, He Y-W, Wu D-H et al (2010) The cyclic nucleotide monophosphate domain of Xanthomonas campestris global regulator Clp defines a new class of cyclic di-GMP effectors. J Bacteriol 192:1020\u20131029","journal-title":"J Bacteriol"},{"key":"4091_CR41","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1128\/jb.179.17.5574-5581.1997","volume":"179","author":"SK Arora","year":"1997","unstructured":"Arora SK, Ritchings BW, Almira EC et al (1997) A transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner. J Bacteriol 179:5574\u20135581","journal-title":"J Bacteriol"},{"key":"4091_CR42","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00300-18","author":"MW Orr","year":"2018","unstructured":"Orr MW, Weiss CA, Severin GB et al (2018) A subset of exoribonucleases serve as degradative enzymes for pGpG in c-di-GMP signaling. J Bacteriol. https:\/\/doi.org\/10.1128\/JB.00300-18","journal-title":"J Bacteriol"},{"key":"4091_CR43","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/mmi.15119","volume":"120","author":"U R\u00f6mling","year":"2023","unstructured":"R\u00f6mling U (2023) Cyclic di-GMP signaling\u2014where did you come from and where will you go? Mol Microbiol 120:564\u2013574. https:\/\/doi.org\/10.1111\/mmi.15119","journal-title":"Mol Microbiol"},{"key":"4091_CR44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/978-3-030-33308-9_29","volume-title":"Microbial cyclic di-nucleotide signaling","author":"N Zlatkov","year":"2020","unstructured":"Zlatkov N, Uhlin BE (2020) Unconventional cyclic di-GMP signaling in Escherichia coli. Microbial cyclic di-nucleotide signaling. Springer International Publishing, Cham, pp 487\u2013517"},{"key":"4091_CR45","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/2211-5463.13389","volume":"13","author":"M Condinho","year":"2023","unstructured":"Condinho M, Carvalho B, Cruz A et al (2023) The role of RNA regulators, quorum sensing and c-di-GMP in bacterial biofilm formation. FEBS Open Bio 13:975\u2013991. https:\/\/doi.org\/10.1002\/2211-5463.13389","journal-title":"FEBS Open Bio"},{"key":"4091_CR46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-micro-020518-115555","volume":"73","author":"M Valentini","year":"2019","unstructured":"Valentini M, Filloux A (2019) Multiple roles of c-di-GMP signaling in bacterial pathogenesis. Annu Rev Microbiol 73:387\u2013406","journal-title":"Annu Rev Microbiol"},{"key":"4091_CR47","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/j.1462-2920.2011.02499.x","volume":"13","author":"MA Matilla","year":"2011","unstructured":"Matilla MA, Travieso ML, Ramos JL, Ramos-Gonz\u00e1lez MI (2011) Cyclic diguanylate turnover mediated by the sole GGDEF\/EAL response regulator in Pseudomonas putida: its role in the rhizosphere and an analysis of its target processes. Environ Microbiol 13:1745\u20131766","journal-title":"Environ Microbiol"},{"key":"4091_CR48","first-page":"2","volume":"3","author":"D-G Ha","year":"2015","unstructured":"Ha D-G, O\u2019Toole GA (2015) c-di-GMP and its effects on biofilm formation and dispersion: a Pseudomonas aeruginosa review. Microbiol Spectr 3:2\u20133","journal-title":"Microbiol Spectr"},{"key":"4091_CR49","doi-asserted-by":"crossref","first-page":"e1454","DOI":"10.1002\/wrna.1454","volume":"9","author":"CL Hall","year":"2018","unstructured":"Hall CL, Lee VT (2018) Cyclic-di-GMP regulation of virulence in bacterial pathogens. Wiley Interdiscip Rev RNA 9:e1454","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"4091_CR50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/JB.00520-15","volume":"198","author":"TL Povolotsky","year":"2016","unstructured":"Povolotsky TL, Hengge R (2016) Genome-based comparison of cyclic di-GMP signaling in pathogenic and commensal Escherichia coli strains. J Bacteriol 198:111\u2013126","journal-title":"J Bacteriol"},{"key":"4091_CR51","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MMBR.00078-15","volume":"80","author":"MK Paczosa","year":"2016","unstructured":"Paczosa MK, Mecsas J (2016) Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev 80:629\u2013661","journal-title":"Microbiol Mol Biol Rev"},{"key":"4091_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-12-1","volume":"12","author":"DP Cruz","year":"2012","unstructured":"Cruz DP, Huertas MG, Lozano M et al (2012) Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae. BMC Microbiol 12:1\u20139","journal-title":"BMC Microbiol"},{"key":"4091_CR53","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1534-5807(03)00295-8","volume":"5","author":"J Zhu","year":"2003","unstructured":"Zhu J, Mekalanos JJ (2003) Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Dev Cell 5:647\u2013656","journal-title":"Dev Cell"},{"key":"4091_CR54","doi-asserted-by":"crossref","first-page":"12860","DOI":"10.1074\/jbc.M611593200","volume":"282","author":"JT Pratt","year":"2007","unstructured":"Pratt JT, Tamayo R, Tischler AD, Camilli A (2007) PilZ domain proteins bind cyclic diguanylate and regulate diverse processes in Vibrio cholerae. J Biol Chem 282:12860\u201312870","journal-title":"J Biol Chem"},{"key":"4091_CR55","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/mmi.12066","volume":"86","author":"IS Pultz","year":"2012","unstructured":"Pultz IS, Christen M, Kulasekara HD et al (2012) The response threshold of S almonella PilZ domain proteins is determined by their binding affinities for c-di-GMP. Mol Microbiol 86:1424\u20131440","journal-title":"Mol Microbiol"},{"key":"4091_CR56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.anaerobe.2015.10.009","volume":"37","author":"C Janoir","year":"2016","unstructured":"Janoir C (2016) Virulence factors of Clostridium difficile and their role during infection. Anaerobe 37:13\u201324","journal-title":"Anaerobe"},{"key":"4091_CR57","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fcimb.2014.00056","volume":"4","author":"EA Novak","year":"2014","unstructured":"Novak EA, Sultan SZ, Motaleb MA (2014) The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burdorferi. Front Cell Infect Microbiol 4:56","journal-title":"Front Cell Infect Microbiol"},{"key":"4091_CR58","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3389\/fmicb.2018.00764","volume":"9","author":"G Xiao","year":"2018","unstructured":"Xiao G, Kong L, Che R et al (2018) Identification and characterization of c-di-GMP metabolic enzymes of Leptospira interrogans and c-di-GMP fluctuations after thermal shift and infection. Front Microbiol 9:764","journal-title":"Front Microbiol"},{"key":"4091_CR59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJM200101043440110","volume":"344","author":"GL Archer","year":"2001","unstructured":"Archer GL, Climo MW (2001) Staphylococcus aureus bacteremia\u2014consider the source. N Engl J Med 344:55\u201356","journal-title":"N Engl J Med"},{"key":"4091_CR60","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/IAI.01405-08","volume":"77","author":"F Shang","year":"2009","unstructured":"Shang F, Xue T, Sun H et al (2009) The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849\u20132856","journal-title":"Infect Immun"},{"key":"4091_CR61","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/jph.12366","volume":"163","author":"X Wang","year":"2015","unstructured":"Wang X, Bi T, Li X et al (2015) First report of corn whorl rot caused by Serratia marcescens in China. J Phytopathol 163:1059\u20131063","journal-title":"J Phytopathol"},{"key":"4091_CR62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/bioinformatics\/bti739","volume":"22","author":"D Amikam","year":"2006","unstructured":"Amikam D, Galperin MY (2006) PilZ domain is part of the bacterial c-di-GMP binding protein. Bioinformatics 22:3\u20136","journal-title":"Bioinformatics"},{"key":"4091_CR63","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1073\/pnas.0607738104","volume":"104","author":"M Christen","year":"2007","unstructured":"Christen M, Christen B, Allan MG et al (2007) DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus. Proc Natl Acad Sci 104:4112\u20134117","journal-title":"Proc Natl Acad Sci"},{"key":"4091_CR64","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1365-2958.2008.06281.x","volume":"69","author":"JW Hickman","year":"2008","unstructured":"Hickman JW, Harwood CS (2008) Identification of FleQ from Pseudomonas aeruginosa as ac-di-GMP-responsive transcription factor. Mol Microbiol 69:376\u2013389","journal-title":"Mol Microbiol"},{"key":"4091_CR65","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1365-2958.2007.05879.x","volume":"65","author":"VT Lee","year":"2007","unstructured":"Lee VT, Matewish JM, Kessler JL et al (2007) A cyclic-di-GMP receptor required for bacterial exopolysaccharide production. Mol Microbiol 65:1474\u20131484","journal-title":"Mol Microbiol"},{"key":"4091_CR66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1101\/gad.502409","volume":"23","author":"A Duerig","year":"2009","unstructured":"Duerig A, Abel S, Folcher M et al (2009) Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression. Genes Dev 23:93\u2013104","journal-title":"Genes Dev"},{"key":"4091_CR67","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1038\/sj.emboj.7601918","volume":"26","author":"J Benach","year":"2007","unstructured":"Benach J, Swaminathan SS, Tamayo R et al (2007) The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J 26:5153\u20135166","journal-title":"EMBO J"},{"key":"4091_CR68","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/0022034509359403","volume":"89","author":"JB Kaplan","year":"2010","unstructured":"Kaplan JB (2010) Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses. J Dent Res 89:205\u2013218. https:\/\/doi.org\/10.1177\/0022034509359403","journal-title":"J Dent Res"},{"key":"4091_CR69","doi-asserted-by":"publisher","first-page":"7312","DOI":"10.1128\/JB.186.21.7312-7326.2004","volume":"186","author":"K Sauer","year":"2004","unstructured":"Sauer K, Cullen MC, Rickard AH et al (2004) Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm. J Bacteriol 186:7312\u20137326. https:\/\/doi.org\/10.1128\/JB.186.21.7312-7326.2004","journal-title":"J Bacteriol"},{"key":"4091_CR70","doi-asserted-by":"publisher","first-page":"22684","DOI":"10.1021\/acsomega.0c02294","volume":"5","author":"Y Li","year":"2020","unstructured":"Li Y, Xiao P, Wang Y, Hao Y (2020) Mechanisms and control measures of mature biofilm resistance to antimicrobial agents in the clinical context. ACS Omega 5:22684\u201322690. https:\/\/doi.org\/10.1021\/acsomega.0c02294","journal-title":"ACS Omega"},{"key":"4091_CR71","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.bioflm.2021.100059","volume":"3","author":"S Park","year":"2021","unstructured":"Park S, Sauer K (2021) SagS and its unorthodox contributions to Pseudomonas aeruginosa biofilm development. Biofilm 3:100059. https:\/\/doi.org\/10.1016\/j.bioflm.2021.100059","journal-title":"Biofilm"},{"key":"4091_CR72","doi-asserted-by":"crossref","first-page":"12547","DOI":"10.1074\/jbc.R115.711507","volume":"291","author":"M Valentini","year":"2016","unstructured":"Valentini M, Filloux A (2016) Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria. J Biol Chem 291:12547\u201312555","journal-title":"J Biol Chem"},{"key":"4091_CR73","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1128\/JB.00732-13","volume":"195","author":"K Gupta","year":"2013","unstructured":"Gupta K, Marques CNH, Petrova OE, Sauer K (2013) Antimicrobial tolerance of pseudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two-component hybrid SagS. J Bacteriol 195:4975\u20134987. https:\/\/doi.org\/10.1128\/JB.00732-13","journal-title":"J Bacteriol"},{"key":"4091_CR74","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00242-13","author":"V Huangyutitham","year":"2013","unstructured":"Huangyutitham V, G\u00fcvener ZT, Harwood CS (2013) Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity. MBio. https:\/\/doi.org\/10.1128\/mBio.00242-13","journal-title":"MBio"},{"key":"4091_CR75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-031-08491-1_3","volume-title":"Pseudomonas aeruginosa: biology, pathogenesis and control strategies","author":"S Park","year":"2022","unstructured":"Park S, Sauer K (2022) Controlling biofilm development through cyclic di-GMP signaling. Pseudomonas aeruginosa: biology, pathogenesis and control strategies. Springer, Cham, pp 69\u201394"},{"key":"4091_CR76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2117633119","author":"L O\u2019Neal","year":"2022","unstructured":"O\u2019Neal L, Baraquet C, Suo Z et al (2022) The Wsp system of Pseudomonas aeruginosa links surface sensing and cell envelope stress. Proc Natl Acad Sci. https:\/\/doi.org\/10.1073\/pnas.2117633119","journal-title":"Proc Natl Acad Sci"},{"key":"4091_CR77","doi-asserted-by":"publisher","first-page":"e1004480","DOI":"10.1371\/journal.ppat.1004480","volume":"10","author":"AI Chen","year":"2014","unstructured":"Chen AI, Dolben EF, Okegbe C et al (2014) Candida albicans Ethanol Stimulates Pseudomonas aeruginosa WspR-controlled biofilm formation as part of a cyclic relationship involving Phenazines. PLoS Pathog 10:e1004480. https:\/\/doi.org\/10.1371\/journal.ppat.1004480","journal-title":"PLoS Pathog"},{"key":"4091_CR78","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/antibiotics12010124","volume":"12","author":"L Soldevila-Boixader","year":"2023","unstructured":"Soldevila-Boixader L, Fern\u00e1ndez AP, Laguna JM, U\u00e7kay I (2023) Local antibiotics in the treatment of diabetic foot infections: a narrative review. Antibiotics 12:124. https:\/\/doi.org\/10.3390\/antibiotics12010124","journal-title":"Antibiotics"},{"key":"4091_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00419","author":"P Krzyszczyk","year":"2018","unstructured":"Krzyszczyk P, Schloss R, Palmer A, Berthiaume F (2018) The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2018.00419","journal-title":"Front Physiol"},{"key":"4091_CR80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216321","author":"S Nirenjen","year":"2023","unstructured":"Nirenjen S, Narayanan J, Tamilanban T et al (2023) Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2023.1216321","journal-title":"Front Immunol"},{"key":"4091_CR81","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.3390\/ijms22063128","volume":"22","author":"I Jurado-Mart\u00edn","year":"2021","unstructured":"Jurado-Mart\u00edn I, Sainz-Mej\u00edas M, McClean S (2021) Pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors. Int J Mol Sci 22:3128. https:\/\/doi.org\/10.3390\/ijms22063128","journal-title":"Int J Mol Sci"},{"key":"4091_CR82","doi-asserted-by":"publisher","first-page":"137","DOI":"10.5114\/ms.2017.68709","volume":"2","author":"M Cie\u015bluk","year":"2017","unstructured":"Cie\u015bluk M, Piktel E, W\u0105tek M et al (2017) Neutrophil extracellular traps as the main source of eDNA. Med Stud 2:137\u2013145. https:\/\/doi.org\/10.5114\/ms.2017.68709","journal-title":"Med Stud"},{"key":"4091_CR83","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13756-019-0533-3","volume":"8","author":"D Sharma","year":"2019","unstructured":"Sharma D, Misba L, Khan AU (2019) Antibiotics versus biofilm: an emerging battleground in microbial communities. Antimicrob Resist Infect Control 8:76. https:\/\/doi.org\/10.1186\/s13756-019-0533-3","journal-title":"Antimicrob Resist Infect Control"},{"key":"4091_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.550505","author":"T Grainha","year":"2020","unstructured":"Grainha T, Jorge P, Alves D et al (2020) Unraveling Pseudomonas aeruginosa and Candida albicans communication in coinfection scenarios: insights through network analysis. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2020.550505","journal-title":"Front Cell Infect Microbiol"},{"key":"4091_CR85","first-page":"3261","volume":"11","author":"Q Wei","year":"2019","unstructured":"Wei Q, Zhang Z, Luo J et al (2019) Insulin treatment enhances pseudomonas aeruginosa biofilm formation by increasing intracellular cyclic di-GMP levels, leading to chronic wound infection and delayed wound healing. Am J Transl Res 11:3261","journal-title":"Am J Transl Res"},{"key":"4091_CR86","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1136\/thx.53.3.213","volume":"53","author":"R Wilson","year":"1998","unstructured":"Wilson R, Dowling RB (1998) Pseudomonas aeruginosa and other related species. Thorax 53:213\u2013219. https:\/\/doi.org\/10.1136\/thx.53.3.213","journal-title":"Thorax"},{"key":"4091_CR87","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1042\/BST20220845","volume":"51","author":"S Anantharaman","year":"2023","unstructured":"Anantharaman S, Guercio D, Mendoza AG et al (2023) Negative regulation of biofilm formation by nitric oxide sensing proteins. Biochem Soc Trans 51:1447\u20131458. https:\/\/doi.org\/10.1042\/BST20220845","journal-title":"Biochem Soc Trans"},{"key":"4091_CR88","doi-asserted-by":"publisher","first-page":"105659","DOI":"10.1016\/j.jbc.2024.105659","volume":"300","author":"K Eilers","year":"2024","unstructured":"Eilers K, Hoong Yam JK, Liu X et al (2024) The dual GGDEF\/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture. J Biol Chem 300:105659. https:\/\/doi.org\/10.1016\/j.jbc.2024.105659","journal-title":"J Biol Chem"},{"key":"4091_CR89","doi-asserted-by":"publisher","first-page":"7344","DOI":"10.1128\/JB.00779-06","volume":"188","author":"N Barraud","year":"2006","unstructured":"Barraud N, Hassett DJ, Hwang S-H et al (2006) Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J Bacteriol 188:7344\u20137353. https:\/\/doi.org\/10.1128\/JB.00779-06","journal-title":"J Bacteriol"},{"key":"4091_CR90","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/oxfordjournals.pcp.a029351","volume":"39","author":"P Ohana","year":"1998","unstructured":"Ohana P, Delmer DP, Carlson RW et al (1998) Identification of a novel triterpenoid saponin from Pisum sativum as a specific inhibitor of the diguanylate cyclase of Acetobacter xylinum. Plant Cell Physiol 39:144\u2013152","journal-title":"Plant Cell Physiol"},{"key":"4091_CR91","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/08927014.2013.832224","volume":"30","author":"K Sambanthamoorthy","year":"2014","unstructured":"Sambanthamoorthy K, Luo C, Pattabiraman N et al (2014) Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30:17\u201328","journal-title":"Biofouling"},{"key":"4091_CR92","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1039\/C6SC02103D","volume":"7","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Tsuji G, Opoku-Temeng C, Sintim HO (2016) Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative. Chem Sci 7:6238\u20136244","journal-title":"Chem Sci"},{"key":"4091_CR93","first-page":"1","volume":"8","author":"B Kim","year":"2018","unstructured":"Kim B, Park J-S, Choi H-Y et al (2018) Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP. Sci Rep 8:1\u201313","journal-title":"Sci Rep"},{"key":"4091_CR94","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1007\/s00253-013-4875-0","volume":"97","author":"D Antoniani","year":"2013","unstructured":"Antoniani D, Rossi E, Rinaldo S et al (2013) The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability. Appl Microbiol Biotechnol 97:7325\u20137336","journal-title":"Appl Microbiol Biotechnol"},{"key":"4091_CR95","doi-asserted-by":"publisher","first-page":"162180","DOI":"10.1016\/j.scitotenv.2023.162180","volume":"872","author":"H-S Kim","year":"2023","unstructured":"Kim H-S, Ham S-Y, Ryoo H-S et al (2023) Inhibiting bacterial biofilm formation by stimulating c-di-GMP regulation using citrus peel extract from Jeju Island. Sci Total Environ 872:162180. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.162180","journal-title":"Sci Total Environ"},{"key":"4091_CR96","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/mlf2.12087","volume":"2","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Bhasme P, Reddy DS et al (2023) Dual functions: a coumarin\u2013chalcone conjugate inhibits cyclic-di-GMP and quorum-sensing signaling to reduce biofilm formation and virulence of pathogens. mLife 2:283\u2013294. https:\/\/doi.org\/10.1002\/mlf2.12087","journal-title":"mLife"},{"key":"4091_CR97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/cb400485k","volume":"9","author":"OJ Lieberman","year":"2014","unstructured":"Lieberman OJ, Orr MW, Wang Y, Lee VT (2014) High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. ACS Chem Biol 9:183\u2013192","journal-title":"ACS Chem Biol"},{"key":"4091_CR98","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00003-23","author":"S Park","year":"2023","unstructured":"Park S, Dingemans J, Sauer K (2023) Manganese acts as an environmental inhibitor of pseudomonas aeruginosa biofilm development by inducing dispersion and modulating c-di-GMP and exopolysaccharide production via RbdA. J Bacteriol. https:\/\/doi.org\/10.1128\/jb.00003-23","journal-title":"J Bacteriol"},{"key":"4091_CR99","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00117-20","author":"LJ Kahl","year":"2020","unstructured":"Kahl LJ, Price-Whelan A, Dietrich LEP (2020) Light-mediated decreases in cyclic di-GMP levels inhibit structure formation in pseudomonas aeruginosa biofilms. J Bacteriol. https:\/\/doi.org\/10.1128\/JB.00117-20","journal-title":"J Bacteriol"},{"key":"4091_CR100","doi-asserted-by":"publisher","first-page":"114154","DOI":"10.1016\/j.celrep.2024.114154","volume":"43","author":"C Kennelly","year":"2024","unstructured":"Kennelly C, Tran P, Prindle A (2024) Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism. Cell Rep 43:114154. https:\/\/doi.org\/10.1016\/j.celrep.2024.114154","journal-title":"Cell Rep"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04091-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-025-04091-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04091-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T10:50:08Z","timestamp":1739616608000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-025-04091-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["4091"],"URL":"https:\/\/doi.org\/10.1007\/s00284-025-04091-7","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"28 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"118"}}