{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:33:24Z","timestamp":1792683204669,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["150679\/2021-1"],"award-info":[{"award-number":["150679\/2021-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02067-22"],"award-info":[{"award-number":["APQ-02067-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00284-025-04117-0","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:07:49Z","timestamp":1740150469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determining the Antimycobacterial Action of Rottlerin Against Mycobacterium Species and Toxicity, Antioxidant Properties, and Therapeutic Target Affinity of Rottlerin"],"prefix":"10.1007","volume":"82","author":[{"given":"Jaqueline Lopes","family":"Damasceno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Brentini","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralciane de Paula","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e1bata Rodrigues","family":"Esperandim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Duarte","family":"Ozelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Vit\u00f3ria Franco da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel Rodrigues","family":"Landaeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Crispim","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Carlos Scalon","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00edsa Am\u00e1lia Vieira","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Alves de Melo","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-6878","authenticated-orcid":false,"given":"Carlos Henrique Gomes","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"issue":"3","key":"4117_CR1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3978\/j.issn.2072-1439.2013.12.24","volume":"6","author":"MM Johnson","year":"2014","unstructured":"Johnson MM, Odell JA (2014) Nontuberculous mycobacterial pulmonary infections. J Thorac Dis 6(3):210\u2013220. https:\/\/doi.org\/10.3978\/j.issn.2072-1439.2013.12.24","journal-title":"J Thorac Dis"},{"key":"4117_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00667-6","author":"R Gopalaswamy","year":"2020","unstructured":"Gopalaswamy R, Shanmugam S, Mondal R, Subbian S (2020) Of tuberculosis and non-tuberculous mycobacterial infections\u2014a comparative analysis of epidemiology, diagnosis and treatment. J Biomed Sci. https:\/\/doi.org\/10.1186\/s12929-020-00667-6","journal-title":"J Biomed Sci"},{"issue":"6","key":"4117_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.tim.2018.02.012","volume":"26","author":"A Koch","year":"2018","unstructured":"Koch A, Mizrahi V (2018) Mycobacterium tuberculosis. Trends Microbiol 26(6):555\u2013556. https:\/\/doi.org\/10.1016\/j.tim.2018.02.012","journal-title":"Trends Microbiol"},{"issue":"11","key":"4117_CR4","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1099\/jmm.0.000171","volume":"64","author":"AL Banuls","year":"2015","unstructured":"Banuls AL, Sanou A, Van Anh NT, Godreuil S (2015) Mycobacterium tuberculosis: ecology and evolution of a human bacterium. J Med Microbiol 64(11):1261\u20131269. https:\/\/doi.org\/10.1099\/jmm.0.000171","journal-title":"J Med Microbiol"},{"issue":"12","key":"4117_CR5","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1007\/s10096-017-3082-9","volume":"36","author":"HC Lin","year":"2017","unstructured":"Lin HC, Perng CL, Lai YW, Lin FG, Chiang CJ, Lin HA, Jou R, Chiueh TS (2017) Molecular screening of multidrug-resistance tuberculosis by a designated public health laboratory in Taiwan. Eur J Clin Microbiol Infect Dis 36(12):2431\u20132439. https:\/\/doi.org\/10.1007\/s10096-017-3082-9","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4117_CR6","unstructured":"PAHO\/WHO Tuberculosis deaths and disease increase during the COVID-19 pandemic. https:\/\/www.paho.org\/en\/news\/27-10-2022-tuberculosis-deaths-and-disease-increase-during-covid-19-pandemic. Accessed 23 Aug, 2023"},{"issue":"6","key":"4117_CR7","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1183\/09031936.00149212","volume":"42","author":"W Hoefsloot","year":"2013","unstructured":"Hoefsloot W, van Ingen J, Andrejak C et al (2013) The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study. Eur Respir J 42(6):1604\u20131613. https:\/\/doi.org\/10.1183\/09031936.00149212","journal-title":"Eur Respir J"},{"issue":"8","key":"4117_CR8","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1016\/j.bmcl.2012.02.053","volume":"22","author":"S Sureram","year":"2012","unstructured":"Sureram S, Senadeera SP, Hongmanee P, Mahidol C, Ruchirawat S, Kittakoop P (2012) Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. Bioorg Med Chem Lett 22(8):2902\u20132905. https:\/\/doi.org\/10.1016\/j.bmcl.2012.02.053","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"4117_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/adt.2015.673","volume":"14","author":"SI Farah","year":"2016","unstructured":"Farah SI, Abdelrahman AA, North EJ, Chauhan H (2016) Opportunities and challenges for natural products as novel antituberculosis agents. Assay Drug Dev Technol 14(1):29\u201338. https:\/\/doi.org\/10.1089\/adt.2015.673","journal-title":"Assay Drug Dev Technol"},{"key":"4117_CR10","doi-asserted-by":"publisher","first-page":"279451","DOI":"10.1155\/2014\/279451","volume":"2014","author":"M Gangwar","year":"2014","unstructured":"Gangwar M, Gautam MK, Sharma AK, Tripathi YB, Goel RK, Nath G (2014) Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. Scientific World J 2014:279451. https:\/\/doi.org\/10.1155\/2014\/279451","journal-title":"Scientific World J"},{"issue":"1","key":"4117_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jep.2008.06.034","volume":"119","author":"A Hussain","year":"2008","unstructured":"Hussain A, Khan MN, Iqbal Z, Sajid MS (2008) An account of the botanical anthelmintics used in traditional veterinary practices in Sahiwal district of Punjab Pakistan. J Ethnopharmacol 119(1):185\u2013190. https:\/\/doi.org\/10.1016\/j.jep.2008.06.034","journal-title":"J Ethnopharmacol"},{"key":"4117_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/213973","author":"M Gangwar","year":"2014","unstructured":"Gangwar M, Goel RK, Nath G (2014) Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review. Biomed Res Int. https:\/\/doi.org\/10.1155\/2014\/213973","journal-title":"Biomed Res Int"},{"key":"4117_CR13","doi-asserted-by":"publisher","first-page":"742936","DOI":"10.1155\/2009\/742936","volume":"2009","author":"E Maioli","year":"2009","unstructured":"Maioli E, Greci L, Soucek K, Hyzdalova M, Pecorelli A, Fortino V, Valacchi G (2009) Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. J Biomed Biotechnol 2009:742936. https:\/\/doi.org\/10.1155\/2009\/742936","journal-title":"J Biomed Biotechnol"},{"issue":"3","key":"4117_CR14","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.3892\/mmr.2018.9293","volume":"18","author":"J Song","year":"2018","unstructured":"Song J, Zhou Y, Gong Y, Liu H, Tang L (2018) Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines. Mol Med Rep 18(3):2905\u20132913. https:\/\/doi.org\/10.3892\/mmr.2018.9293","journal-title":"Mol Med Rep"},{"issue":"4","key":"4117_CR15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1248\/bpb.32.631","volume":"32","author":"SF Zaidi","year":"2009","unstructured":"Zaidi SF, Yoshida I, Butt F, Yusuf MA, Usmanghani K, Kadowaki M, Sugiyama T (2009) Potent bactericidal constituents from Mallotus philippinensis against clarithromycin and metronidazole resistant strains of Japanese and Pakistani Helicobacter pylori. Biol Pharm Bull 32(4):631\u2013636. https:\/\/doi.org\/10.1248\/bpb.32.631","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"4117_CR16","first-page":"211","volume":"5","author":"Q Hong","year":"2010","unstructured":"Hong Q, Minter DE, Franzblau SG, Arfan M, Amin H, Reinecke MG (2010) Anti-tuberculosis compounds from Mallotus philippinensis. Nat Prod Commun 5(2):211\u2013217","journal-title":"Nat Prod Commun"},{"issue":"8","key":"4117_CR17","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1128\/AAC.46.8.2720-2722.2002","volume":"46","author":"JC Palomino","year":"2002","unstructured":"Palomino JC, Martin A, Camacho M, Guerra H, Swings J, Portaels F (2002) Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 46(8):2720\u20132722. https:\/\/doi.org\/10.1128\/AAC.46.8.2720-2722.2002","journal-title":"Antimicrob Agents Chemother"},{"key":"4117_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2217\/fmb-2019-0050","volume":"15","author":"NCS Santos","year":"2020","unstructured":"Santos NCS, Scodro RBL, Leal DC et al (2020) Determination of minimum bactericidal concentration, in single or combination drugs, against Mycobacterium tuberculosis. Future Microbiol 15:107\u2013114. https:\/\/doi.org\/10.2217\/fmb-2019-0050","journal-title":"Future Microbiol"},{"key":"4117_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700149","author":"MH Soares","year":"2017","unstructured":"Soares MH, Dias HJ, Vieira TM et al (2017) Chemical composition, antibacterial, schistosomicidal, and cytotoxic activities of the essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae). Chem Biodivers. https:\/\/doi.org\/10.1002\/cbdv.201700149","journal-title":"Chem Biodivers"},{"key":"4117_CR20","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1590\/S0100-40422007000200021","volume":"30","author":"CMDM Sousa","year":"2007","unstructured":"Sousa CMDM, Silva HR, Vieira GM et al (2007) Fen\u00f3is totais e atividade antioxidante de cinco plantas medicinais. Quim Nova 30:351\u2013355","journal-title":"Quim Nova"},{"issue":"1","key":"4117_CR21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (2000) The protein data bank. Nucleic Acids Res 28(1):235\u2013242. https:\/\/doi.org\/10.1093\/nar\/28.1.235","journal-title":"Nucleic Acids Res"},{"issue":"7873","key":"4117_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A et al (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596(7873):583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2","journal-title":"Nature"},{"issue":"D1","key":"4117_CR23","doi-asserted-by":"publisher","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","volume":"51","author":"C UniProt","year":"2023","unstructured":"UniProt C (2023) UniProt: the universal protein knowledgebase in 2023. Nucleic Acids Res 51(D1):D523\u2013D531. https:\/\/doi.org\/10.1093\/nar\/gkac1052","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4117_CR24","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","volume":"51","author":"S Kim","year":"2023","unstructured":"Kim S, Chen J, Cheng T et al (2023) PubChem 2023 update. Nucleic Acids Res 51(D1):D1373\u2013D1380. https:\/\/doi.org\/10.1093\/nar\/gkac956","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"4117_CR25","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"G Jones","year":"1997","unstructured":"Jones G, Willett P, Glen RC, Leach AR, Taylor R (1997) Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267(3):727\u2013748. https:\/\/doi.org\/10.1006\/jmbi.1996.0897","journal-title":"J Mol Biol"},{"issue":"1","key":"4117_CR26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1021\/ci800298z","volume":"49","author":"O Korb","year":"2009","unstructured":"Korb O, Stutzle T, Exner TE (2009) Empirical scoring functions for advanced protein-ligand docking with PLANTS. J Chem Inf Model 49(1):84\u201396. https:\/\/doi.org\/10.1021\/ci800298z","journal-title":"J Chem Inf Model"},{"issue":"3","key":"4117_CR27","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1109\/mcse.2007.55","volume":"9","author":"JD Hunter","year":"2007","unstructured":"Hunter JD (2007) Matplotlib: A 2D graphics environment. Comput Sci Eng 9(3):90\u201395. https:\/\/doi.org\/10.1109\/mcse.2007.55","journal-title":"Comput Sci Eng"},{"key":"4117_CR28","doi-asserted-by":"publisher","unstructured":"McKinney W (2010) Data structures for statistical computing in python. In proceedings of the 9th python in science conference: 51\u201356. https:\/\/doi.org\/10.25080\/Majora-92bf1922-00a.","DOI":"10.25080\/Majora-92bf1922-00a"},{"key":"4117_CR29","unstructured":"BIOVIA, Dassault Syst\u00e8mes, Discovery Studio 2021, v. 21.1.0.20298, San Diego: Dassault Syst\u00e8mes, 2021."},{"issue":"7","key":"4117_CR30","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1016\/S1473-3099(18)30110-5","volume":"18","author":"S Tiberi","year":"2018","unstructured":"Tiberi S, du Plessis N, Walzl G et al (2018) Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies. Lancet Infect Dis 18(7):e183\u2013e198. https:\/\/doi.org\/10.1016\/S1473-3099(18)30110-5","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"4117_CR31","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/cid\/ciaa1125","volume":"71","author":"CL Daley","year":"2020","unstructured":"Daley CL, Iaccarino JM, Lange C et al (2020) Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline. Clin Infect Dis 71(4):905\u2013913. https:\/\/doi.org\/10.1093\/cid\/ciaa1125","journal-title":"Clin Infect Dis"},{"issue":"17","key":"4117_CR32","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.4155\/fmc-2018-0281","volume":"12","author":"CT Pires","year":"2020","unstructured":"Pires CT, Scodro RB, Cortez DA et al (2020) Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis. Future Med Chem 12(17):1533\u20131546. https:\/\/doi.org\/10.4155\/fmc-2018-0281","journal-title":"Future Med Chem"},{"issue":"43","key":"4117_CR33","doi-asserted-by":"publisher","first-page":"10423","DOI":"10.1002\/chem.201701812","volume":"23","author":"SA Villaume","year":"2017","unstructured":"Villaume SA, Fu J, N\u2019Go I, Liang H, Lou H, Kremer L, Pan W, Vincent SP (2017) Natural and synthetic flavonoids as potent Mycobacterium tuberculosis UGM inhibitors. Chemistry 23(43):10423\u201310429. https:\/\/doi.org\/10.1002\/chem.201701812","journal-title":"Chemistry"},{"issue":"5","key":"4117_CR34","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1080\/14786419.2020.1868461","volume":"36","author":"CCM Jesus","year":"2022","unstructured":"Jesus CCM, Araujo MH, Simao T, Lasunskaia EB, Barth T, Muzitano MF, Pinto SC (2022) Natural products from Vitex polygama and their antimycobacterial and anti-inflammatory activity. Nat Prod Res 36(5):1337\u20131341. https:\/\/doi.org\/10.1080\/14786419.2020.1868461","journal-title":"Nat Prod Res"},{"issue":"6","key":"4117_CR35","doi-asserted-by":"publisher","first-page":"e0267222","DOI":"10.1128\/spectrum.02672-22","volume":"10","author":"JR Sullivan","year":"2022","unstructured":"Sullivan JR, Yao J, Courtine C, Lupien A, Herrmann J, Muller R, Behr MA (2022) Natural products Lysobactin and Sorangicin A show in vitro activity against Mycobacterium abscessus Complex. Microbiol Spectr 10(6):e0267222. https:\/\/doi.org\/10.1128\/spectrum.02672-22","journal-title":"Microbiol Spectr"},{"issue":"1","key":"4117_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1472-765X.2010.02963.x","volume":"52","author":"VK Gupta","year":"2011","unstructured":"Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL (2011) Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay. Lett Appl Microbiol 52(1):33\u201340. https:\/\/doi.org\/10.1111\/j.1472-765X.2010.02963.x","journal-title":"Lett Appl Microbiol"},{"issue":"2\u20133","key":"4117_CR37","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jep.2004.07.011","volume":"95","author":"F Tosun","year":"2004","unstructured":"Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P (2004) Antimycobacterial screening of some Turkish plants. J Ethnopharmacol 95(2\u20133):273\u2013275. https:\/\/doi.org\/10.1016\/j.jep.2004.07.011","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"4117_CR38","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s13562-011-0045-6","volume":"20","author":"V Sharma","year":"2011","unstructured":"Sharma V (2011) A polyphenolic compound rottlerin demonstrates significant in vitro cytotoxicity against human cancer cell lines: isolation and characterization from the fruits of Mallotus philippinensis. J Plant Biochem Biotechnol 20(2):190\u2013195. https:\/\/doi.org\/10.1007\/s13562-011-0045-6","journal-title":"J Plant Biochem Biotechnol"},{"issue":"1","key":"4117_CR39","doi-asserted-by":"publisher","first-page":"11132","DOI":"10.1038\/s41598-024-61179-z","volume":"14","author":"NBS Silva","year":"2024","unstructured":"Silva NBS, Menezes RP, Goncalves DS et al (2024) Exploring the antifungal, antibiofilm and antienzymatic potential of Rottlerin in an in vitro and in vivo approach. Sci Rep 14(1):11132. https:\/\/doi.org\/10.1038\/s41598-024-61179-z","journal-title":"Sci Rep"},{"issue":"31","key":"4117_CR40","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.2174\/1381612826666200707131500","volume":"26","author":"OH Goncalves","year":"2020","unstructured":"Goncalves OH, Moreira TFM, de Oliveira A, Bracht L, Ineu RP, Leimann FV (2020) Antioxidant activity of encapsulated extracts and bioactives from natural sources. Curr Pharm Des 26(31):3847\u20133861. https:\/\/doi.org\/10.2174\/1381612826666200707131500","journal-title":"Curr Pharm Des"},{"key":"4117_CR41","first-page":"211","volume":"26","author":"P Molyneux","year":"2004","unstructured":"Molyneux P (2004) The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J Sci Technol 26:211\u2013219","journal-title":"Songklanakarin J Sci Technol"},{"issue":"3","key":"4117_CR42","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1745-4522.2007.00086.x","volume":"14","author":"M Arfan","year":"2007","unstructured":"Arfan M, Amin H, Karama\u0106 M, Kosi\u0143Ska A, Shahidi F, Wiczkowski W, Amarowicz R (2007) Antioxidant activity of extracts of Mallotus philippinensis fruit and bark. J Food Lipids 14(3):280\u2013297. https:\/\/doi.org\/10.1111\/j.1745-4522.2007.00086.x","journal-title":"J Food Lipids"},{"issue":"2","key":"4117_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.17221\/1056-cjfs","volume":"27","author":"M Arfan","year":"2009","unstructured":"Arfan M, Amin H, Karama\u0106 M, Kosi\u0143Ska A, Wiczkowski W, Amarowicz R (2009) Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract. Czech J Food Sci 27(2):109\u2013117. https:\/\/doi.org\/10.17221\/1056-cjfs","journal-title":"Czech J Food Sci"},{"issue":"9","key":"4117_CR44","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s10495-008-0244-3","volume":"13","author":"JM Longpre","year":"2008","unstructured":"Longpre JM, Loo G (2008) Protection of human colon epithelial cells against deoxycholate by rottlerin. Apoptosis 13(9):1162\u20131171. https:\/\/doi.org\/10.1007\/s10495-008-0244-3","journal-title":"Apoptosis"},{"key":"4117_CR45","doi-asserted-by":"publisher","first-page":"025","DOI":"10.17348\/era.3.0.25-36","volume":"3","author":"KA Reynertson","year":"2005","unstructured":"Reynertson KA, Basile MJ, Kennelly EJ (2005) Antioxidant potential of seven Myrtaceous fruits. Ethnobot Res Appl 3:025\u2013036","journal-title":"Ethnobot Res Appl"},{"key":"4117_CR46","doi-asserted-by":"publisher","first-page":"5099312","DOI":"10.1155\/2022\/5099312","volume":"2022","author":"J Mi","year":"2022","unstructured":"Mi J, Gong W, Wu X (2022) Advances in key drug target identification and new drug development for tuberculosis. Biomed Res Int 2022:5099312. https:\/\/doi.org\/10.1155\/2022\/5099312","journal-title":"Biomed Res Int"},{"key":"4117_CR47","doi-asserted-by":"publisher","first-page":"125022","DOI":"10.1016\/j.ijbiomac.2023.125022","volume":"243","author":"S Sreelatha","year":"2023","unstructured":"Sreelatha S, Nagarajan U, Natarajan S (2023) Protein targets in Mycobacterium tuberculosis and their inhibitors for therapeutic implications: a narrative review. Int J Biol Macromol 243:125022. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.125022","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"4117_CR48","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbrc.2016.08.014","volume":"478","author":"S Pandey","year":"2016","unstructured":"Pandey S, Chatterjee A, Jaiswal S, Kumar S, Ramachandran R, Srivastava KK (2016) Protein kinase C-delta inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. Biochem Biophys Res Commun 478(2):721\u2013726. https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.014","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4117_CR49","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1038\/s41467-023-39706-9","volume":"14","author":"Z Li","year":"2023","unstructured":"Li Z, Zhang L, Xu K et al (2023) Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. Nat Commun 14(1):4001. https:\/\/doi.org\/10.1038\/s41467-023-39706-9","journal-title":"Nat Commun"},{"issue":"3","key":"4117_CR50","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jsb.2015.04.008","volume":"190","author":"A Chollet","year":"2015","unstructured":"Chollet A, Mourey L, Lherbet C et al (2015) Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. J Struct Biol 190(3):328\u2013337. https:\/\/doi.org\/10.1016\/j.jsb.2015.04.008","journal-title":"J Struct Biol"},{"key":"4117_CR51","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ymben.2016.04.001","volume":"37","author":"M Jia","year":"2016","unstructured":"Jia M, Potter KC, Peters RJ (2016) Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis. Metab Eng 37:24\u201334. https:\/\/doi.org\/10.1016\/j.ymben.2016.04.001","journal-title":"Metab Eng"},{"issue":"3","key":"4117_CR52","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbapap.2017.11.013","volume":"1866","author":"K Eniyan","year":"2018","unstructured":"Eniyan K, Dharavath S, Vijayan R, Bajpai U, Gourinath S (2018) Crystal structure of UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) from Mycobacterium tuberculosis. Biochim Biophys Acta Proteins Proteom 1866(3):397\u2013406. https:\/\/doi.org\/10.1016\/j.bbapap.2017.11.013","journal-title":"Biochim Biophys Acta Proteins Proteom"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04117-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-025-04117-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04117-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:52:41Z","timestamp":1742363561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-025-04117-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4117"],"URL":"https:\/\/doi.org\/10.1007\/s00284-025-04117-0","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"20 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"147"}}