{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:34:54Z","timestamp":1780385694337,"version":"3.54.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["INTER-COST LUC24099 (COST Action CA21145 EURESTOP)"],"award-info":[{"award-number":["INTER-COST LUC24099 (COST Action CA21145 EURESTOP)"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007594","name":"Univerzita Komensk\u00e9ho v Bratislave","doi-asserted-by":"publisher","award":["UK\/3211\/2024"],"award-info":[{"award-number":["UK\/3211\/2024"]}],"id":[{"id":"10.13039\/100007594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003194","name":"Agent\u00fara Ministerstva \u0160kolstva, Vedy, V\u00fdskumu a \u0160portu SR","doi-asserted-by":"publisher","award":["VEGA 1\/0388\/22"],"award-info":[{"award-number":["VEGA 1\/0388\/22"]}],"id":[{"id":"10.13039\/501100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-19-0094"],"award-info":[{"award-number":["APVV-19-0094"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007594","name":"Comenius University in Bratislava","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007594","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Current antibiotics and chemotherapeutics are becoming ineffective because pathogenic bacteria and tumor cells have developed multiple drug resistance. Therefore, it is necessary to find new substances that can be used in treatment, either alone or as sensitizing molecules in combination with existing drugs. Peptaibols are bioactive, membrane-active peptides of non-ribosomal origin, mainly produced by filamentous fungi such as <jats:italic>Trichoderma<\/jats:italic> spp. This study focused on producing peptaibol-rich extracts from <jats:italic>Trichoderma atroviride<\/jats:italic> O1, cultivated on malt extract agar (MA) under circadian and constant darkness conditions for 13\u00a0days. Peptaibol production was detected by MALDI-TOF mass spectrometry after six days of cultivation. The extracts demonstrated antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> strains, particularly the methicillin-resistant variant, but not against the Gram-negative <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. Quorum sensing interference revealed that a peptaibol-rich extract suppressed <jats:italic>Vibrio campbellii<\/jats:italic> BAA-1119\u2019s AI-2 signaling system to a degree comparable with gentamycin. Beyond antibacterial properties, the extracts exhibited notable antiproliferative activity against human ovarian cancer cells and their adriamycin-resistant subline in both 2D and 3D models. Specifically, MA-derived extracts reduced ovarian cancer cell viability by 70% at 50\u00a0\u03bcg\/mL, especially under light\/dark regime of cultivation. Compared to previously published results for PDA-based extracts, MA cultivation shifted the biological effects of peptaibol-containing extracts toward anticancer potential. These findings support the idea that modifying fungal cultivation parameters, the bioactivity of secondary metabolite mixtures can be tailored for specific therapeutic applications.<\/jats:p>","DOI":"10.1007\/s00284-025-04322-x","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T09:11:27Z","timestamp":1750410687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Agar Composition Modulates Production of Trichoderma Peptaibols, Affecting Antibacterial and Antiproliferative Activity"],"prefix":"10.1007","volume":"82","author":[{"given":"Patrik","family":"Mac\u00e1\u0161ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Kapustov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Viktorov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1n","family":"V\u00edgla\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Olejn\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Grey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Laubertov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-109X","authenticated-orcid":false,"given":"Helena","family":"Gbelcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"issue":"17","key":"4322_CR1","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.3390\/ijms22179451","volume":"22","author":"A Ramos","year":"2021","unstructured":"Ramos A, Sadeghi S, Tabatabaeian H (2021) Battling chemoresistance in cancer: root causes and strategies to uproot them. Int J Mol Sci 22(17):9451. https:\/\/doi.org\/10.3390\/ijms22179451","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4322_CR2","first-page":"5174","volume":"13","author":"FC Yang","year":"2022","unstructured":"Yang FC, Wang C, Zhu J, Gai QJ, Mao M, He J, Qin Y, Yao XX, Wang YX, Lu HM, Cao MF, He MM, Wen XM, Leng P, Cai XW, Yao XH, Bian XW, Wang Y (2022) Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain. Am J Cancer Res 13(11):5174\u20135196","journal-title":"Am J Cancer Res"},{"key":"4322_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100916","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wu X, Ren Z, Li Y, Zou W, Chen J, Wang H (2023) Overcoming cancer chemotherapy resistance by the induction of ferroptosis. Drug Resist Updat. https:\/\/doi.org\/10.1016\/j.drup.2022.100916","journal-title":"Drug Resist Updat"},{"key":"4322_CR4","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1158\/1535-7163.MCT-06-0190","volume":"5","author":"L Smith","year":"2006","unstructured":"Smith L, Watson MB, O\u2019Kane SL, Drew PJ, Lind MJ, Cawkwell L (2006) The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther 5:2115\u20132120","journal-title":"Mol Cancer Ther"},{"key":"4322_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fonc.2018.00267","volume":"8","author":"V Sosa Iglesias","year":"2018","unstructured":"Sosa Iglesias V, Giuranno L, Dubois LJ, Theys J, Vooijs M (2018) Drug resistance in non-small cell lung cancer: a potential for NOTCH targeting? Front Oncol 8:267. https:\/\/doi.org\/10.3389\/fonc.2018.00267","journal-title":"Front Oncol"},{"key":"4322_CR6","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ctrv.2012.02.011","volume":"38","author":"S Murray","year":"2012","unstructured":"Murray S, Briasoulis E, Linardou H, Bafaloukos D, Papadimitriou C (2012) Taxane resistance in breast cancer: mechanisms, predictive biomarkers and circumvention strategies. Cancer Treat Rev 38:890\u2013903. https:\/\/doi.org\/10.1016\/j.ctrv.2012.02.011","journal-title":"Cancer Treat Rev"},{"key":"4322_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1166-3","volume":"38","author":"W-C Huang","year":"2019","unstructured":"Huang W-C, Kuo K-T, Wang C-H, Yeh C-T, Wang Y (2019) Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src\/CD155\/MIF functional pathway. J Exp Clin Cancer Res 38:1\u201317. https:\/\/doi.org\/10.1186\/s13046-019-1166-3","journal-title":"J Exp Clin Cancer Res"},{"key":"4322_CR8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10549-014-3105-5","volume":"147","author":"C Vulsteke","year":"2014","unstructured":"Vulsteke C, Pfeil AM, Schwenkglenks M, Pettengell R, Szucs TD, Lambrechts D, Peeters M, van Dam P, Dieudonn\u00e9 A-S, Hatse S (2014) Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel. Breast Cancer Res Treat 147:557\u2013570. https:\/\/doi.org\/10.1007\/s10549-014-3105-5","journal-title":"Breast Cancer Res Treat"},{"key":"4322_CR9","doi-asserted-by":"publisher","first-page":"2826010","DOI":"10.1155\/2020\/2826010","volume":"2020","author":"B Wang","year":"2020","unstructured":"Wang B, Ma N, Zheng X, Li X, Ma X, Hu J, Cao B (2020) GDF15 repression contributes to 5-fluorouracil resistance in human colon cancer by regulating epithelial-mesenchymal transition and apoptosis. BioMed Res Int 2020:2826010","journal-title":"BioMed Res Int"},{"key":"4322_CR10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00280-001-0412-4","volume":"49","author":"NE Sl\u00e1dek","year":"2002","unstructured":"Sl\u00e1dek NE, Kollander R, Sreerama L, Kiang DT (2002) Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Cancer Chemother Pharmacol 49:309\u2013321. https:\/\/doi.org\/10.1007\/s00280-001-0412-4","journal-title":"Cancer Chemother Pharmacol"},{"key":"4322_CR11","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1111\/jcmm.15055","volume":"24","author":"X Wang","year":"2020","unstructured":"Wang X, Xu Z, Sun J, Lv H, Wang Y, Ni Y, Chen S, Hu C, Wang L, Chen W (2020) Cisplatin resistance in gastric cancer cells is involved with GPR30-mediated epithelial-mesenchymal transition. J Cell Mol Med 24:3625\u20133633. https:\/\/doi.org\/10.1111\/jcmm.15055","journal-title":"J Cell Mol Med"},{"key":"4322_CR12","doi-asserted-by":"publisher","first-page":"e0228331","DOI":"10.1371\/journal.pone.0228331","volume":"15","author":"B Mora-Lagos","year":"2020","unstructured":"Mora-Lagos B, Cartas-Espinel I, Riquelme I, Parker AC, Piccolo SR, Viscarra T, Reyes ME, Zanella L, Buchegger K, Ili C (2020) Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines. PLoS ONE 15:e0228331. https:\/\/doi.org\/10.1371\/journal.pone.0228331","journal-title":"PLoS ONE"},{"key":"4322_CR13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.20517\/cdr.2017.02","volume":"1","author":"\u00c9 Ballestreri","year":"2018","unstructured":"Ballestreri \u00c9, Simon D, de Souza AP, Grott CS, Nabinger DD, Dihl RR, Grivicich I (2018) Resistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line: investigating apoptosis, autophagy, and cytogenetic damage. Cancer Drug Resist 1:72\u201381. https:\/\/doi.org\/10.20517\/cdr.2017.02","journal-title":"Cancer Drug Resist"},{"key":"4322_CR14","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.2147\/OTT.S163774","volume":"11","author":"Y Ru","year":"2018","unstructured":"Ru Y, Chen XJ, Guo WZ, Gao SG, Qi YJ, Chen P, Feng XS, Zhang SJ (2018) Neat1_2\u2013sFPQ axis mediates cisplatin resistance in liver cancer cells in vitro. Onco Targets Ther 11:5695. https:\/\/doi.org\/10.2147\/OTT.S163774","journal-title":"Onco Targets Ther"},{"key":"4322_CR15","doi-asserted-by":"publisher","first-page":"e1257","DOI":"10.1038\/cddis.2013.428","volume":"5","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, Castedo M, Kroemer G (2014) Systems biology of cisplatin resistance: past, present and future. Cell Death Dis 5:e1257. https:\/\/doi.org\/10.1038\/cddis.2013.428","journal-title":"Cell Death Dis"},{"key":"4322_CR16","doi-asserted-by":"publisher","first-page":"104290","DOI":"10.1016\/j.yexmp.2019.104290","volume":"110","author":"X Liu","year":"2019","unstructured":"Liu X, Pan CG, Luo ZQ (2019) High expression of NFAT2 contributes to carboplatin resistance in lung cancer. Exp Mol Pathol 110:104290. https:\/\/doi.org\/10.1016\/j.yexmp.2019.104290","journal-title":"Exp Mol Pathol"},{"key":"4322_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-70913-2","volume":"10","author":"Y Hu","year":"2020","unstructured":"Hu Y, Su Y, Lei X, Zhao H, Wang L, Xu T, Guo J, Yang W, Zhang X (2020) LINC00641\/miR-582-5p mediate oxaliplatin resistance by activating autophagy in gastric adenocarcinoma. Sci Rep 10:1\u201311. https:\/\/doi.org\/10.1038\/s41598-020-70913-2","journal-title":"Sci Rep"},{"key":"4322_CR18","doi-asserted-by":"publisher","first-page":"644956","DOI":"10.3389\/fonc.2021.644956","volume":"11","author":"Q Lin","year":"2021","unstructured":"Lin Q, Luo L, Wang H (2021) A new oxaliplatin resistance-related gene signature with strong predicting ability in colon cancer identified by comprehensive profiling. Front Oncol 11:644956. https:\/\/doi.org\/10.3389\/fonc.2021.644956","journal-title":"Front Oncol"},{"issue":"3","key":"4322_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.prp.2016.01.002","volume":"212","author":"X Zhang","year":"2016","unstructured":"Zhang X, Xu P, Ni W, Fan H, Xu J (2016) Downregulated DYRK2 expression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma. Pathol Res Pract 212(3):162\u2013170. https:\/\/doi.org\/10.1016\/j.prp.2016.01.002","journal-title":"Pathol Res Pract"},{"key":"4322_CR20","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/jcmm.12216","volume":"18","author":"X Li","year":"2014","unstructured":"Li X, Yao R, Yue L, Qiu W, Qi W, Liu S, Yao Y, Liang J (2014) FOXM 1 mediates resistance to docetaxel in gastric cancer via up-regulating stathmin. J Cell Mol Med 18:811\u2013823. https:\/\/doi.org\/10.1111\/jcmm.12216","journal-title":"J Cell Mol Med"},{"key":"4322_CR21","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.3390\/ijms18091926","volume":"18","author":"DL Nielsen","year":"2017","unstructured":"Nielsen DL, Palshof JA, Br\u00fcnner N, Stenvang J, Viuff BM (2017) Implications of ABCG2 expression on irinotecan treatment of colorectal cancer patients: a review. Int J Mol Sci 18:1926. https:\/\/doi.org\/10.3390\/ijms18091926","journal-title":"Int J Mol Sci"},{"key":"4322_CR22","doi-asserted-by":"publisher","first-page":"339","DOI":"10.15171\/apb.2017.041","volume":"7","author":"B Mansoori","year":"2017","unstructured":"Mansoori B, Mohammadi A, Davudian S, Shirjang S, Baradaran B (2017) The different mechanisms of cancer drug resistance: a brief review. Adv Pharm Bull 7:339. https:\/\/doi.org\/10.15171\/apb.2017.041","journal-title":"Adv Pharm Bull"},{"issue":"6494","key":"4322_CR23","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT et al (2020) The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368(6494):973\u2013980. https:\/\/doi.org\/10.1126\/science.aay9189","journal-title":"Science"},{"issue":"10325","key":"4322_CR24","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","unstructured":"Antimicrobial Resistance Collaborators (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet 399(10325):629\u2013655. https:\/\/doi.org\/10.1016\/S0140-6736(21)02724-0","journal-title":"The Lancet"},{"issue":"3","key":"4322_CR25","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3390\/ijms23031241","volume":"23","author":"H Guo","year":"2022","unstructured":"Guo H, Tong Y, Cheng J, Abbas Z, Li Z, Wang J, Zhou Y, Si D, Zhang R (2022) Biofilm and small colony variants\u2014an update on staphylococcus aureus strategies toward drug resistance. Int J Mol Sci 23(3):1241","journal-title":"Int J Mol Sci"},{"key":"4322_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020221","author":"GS Castro","year":"2023","unstructured":"Castro GS, Sousa TF, da Silva DF, Pedroso RCN, Menezers KS, Soares MA, Dias GM, Santos AO, Yamagishi MEB, Faria JV, Jonu\u00e1rio AH, Koolen HHF (2023) Characterization of peptaibols produced by a marine strain of the fungus trichoderma endophyticum via mass spectrometry, genome mining and phylogeny-based prediction. Metabolites. https:\/\/doi.org\/10.3390\/metabo13020221","journal-title":"Metabolites"},{"issue":"5","key":"4322_CR27","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1039\/b618086h","volume":"24","author":"SJF Daniel","year":"2007","unstructured":"Daniel SJF, Filho ER (2007) Peptaibols of Trichoderma. Nat Prod Rep 24(5):1128\u20131141","journal-title":"Nat Prod Rep"},{"issue":"19","key":"4322_CR28","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.3390\/molecules26196025","volume":"26","author":"J V\u00edgla\u0161","year":"2021","unstructured":"V\u00edgla\u0161 J, Dobiasova S, Viktorova J, Ruml T, Repiska V, Olejnikova P et al (2021) Peptaibol-containing extracts of Trichoderma atroviride and the fight against resistant microorganisms and cancer cells. Molecules 26(19):6025. https:\/\/doi.org\/10.3390\/molecules26196025","journal-title":"Molecules"},{"issue":"3","key":"4322_CR29","doi-asserted-by":"publisher","first-page":"100026","DOI":"10.1016\/j.engmic.2022.100026","volume":"2","author":"X Hou","year":"2022","unstructured":"Hou X, Sun R, Feng Y, Zhang R, Zhu T, Che Q, Zhang G, Li D (2022) Peptaibols: diversity, bioactivity, and biosynthesis. Eng Microbiol 2(3):100026. https:\/\/doi.org\/10.1016\/j.engmic.2022.100026","journal-title":"Eng Microbiol"},{"issue":"11","key":"4322_CR30","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/S1875-5364(23)60499-6","volume":"21","author":"P Tang","year":"2023","unstructured":"Tang P, Huang D, Zheng KX, Hu D, Dai P, Li CH, Qin SY, Chen GD, Yao XS, Gao H (2023) Thirteen new peptaibols with antimicrobial activities from Trichoderma sp. Chin J Nat Med 21(11):868\u2013880. https:\/\/doi.org\/10.1016\/S1875-5364(23)60499-6","journal-title":"Chin J Nat Med"},{"key":"4322_CR31","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3390\/fermentation9050422","volume":"9","author":"AE Kuvarina","year":"2023","unstructured":"Kuvarina AE, Sukonnikov MA, Timofeeva AV, Serebryakova MV, Baratova LA, Buzurnyuk MN, Golyshkin AV, Georgieva ML, Sadykova VS (2023) Uncovering the effects of the cultivation condition on different forms of peptaibol\u2019s emericellipsins production from an alkaliphilic fungus. Emericellopsis alkalina. Fermentation 9:422. https:\/\/doi.org\/10.3390\/fermentation9050422","journal-title":"Fermentation"},{"key":"4322_CR32","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.bmcl.2017.01.033","volume":"27","author":"M Gajd\u00e1cs","year":"2017","unstructured":"Gajd\u00e1cs M, Spengler G, Sanmart\u00edn C, Mar\u0107 MA, Handzlik J, Dom\u00ednguez-\u00c1lvarez E (2017) Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: a confirmation study in a colon cancer MDR cell line. Bioorg Med Chem Lett 27:797\u2013802. https:\/\/doi.org\/10.1016\/j.bmcl.2017.01.033","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"4322_CR33","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3390\/antibiotics9080444","volume":"9","author":"J Viktorov\u00e1","year":"2020","unstructured":"Viktorov\u00e1 J, Kumar R, \u0158eho\u0159ov\u00e1 K, Hoang L, Ruml T, Figueroa CR, Valdenegro M, Fuentes L (2020) Antimicrobial activity of extracts of two native fruits of Chile: arrayan (Luma apiculata) and peumo (Cryptocarya alba). Antibiotics 9(8):444. https:\/\/doi.org\/10.3390\/antibiotics9080444","journal-title":"Antibiotics"},{"key":"4322_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s13659-024-00452-0","volume":"14","author":"A Evidente","year":"2024","unstructured":"Evidente A (2024) Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012\u20132023). Nat Prod Bioprospect 14:31. https:\/\/doi.org\/10.1007\/s13659-024-00452-0","journal-title":"Nat Prod Bioprospect"},{"key":"4322_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1021\/np200906s","volume":"75","author":"DJ Newman","year":"2012","unstructured":"Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75:311\u2013335","journal-title":"J Nat Prod"},{"issue":"1","key":"4322_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/2191-0855-3-71","volume":"3","author":"KM Vandermolen","year":"2013","unstructured":"Vandermolen KM, Raja HA, El-Elimat T, Oberlies NH (2013) Evaluation of culture media for the production of secondary metabolites in a natural products screening program. AMB Express 3(1):71. https:\/\/doi.org\/10.1186\/2191-0855-3-71","journal-title":"AMB Express"},{"key":"4322_CR37","doi-asserted-by":"publisher","DOI":"10.1128\/ec.00143-07","author":"M Komon-Zelazowska","year":"2007","unstructured":"Komon-Zelazowska M, Neuhof T, Dieckmann R, von D\u00f6hren H, Herrera-Estrella A, Kubicek CP, Druzhinina IS (2007) Formation of atroviridin by hypocrea atroviridis is conidiation associated and positively regulated by blue light and the G protein GNA3. Eukaryot Cell. https:\/\/doi.org\/10.1128\/ec.00143-07","journal-title":"Eukaryot Cell"},{"issue":"10","key":"4322_CR38","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/jof8101037","volume":"8","author":"P Alfaro-Vargas","year":"2022","unstructured":"Alfaro-Vargas P, Bastos-Salas A, Mu\u00f1oz-Arrieta R, Pereira-Reyes R, Redondo-Solano M, Fern\u00e1ndez J, Mora-Villalobos A, L\u00f3pez-G\u00f3mez JP (2022) Peptaibol production and characterization from Trichoderma asperellum and their action as biofungicide. J Fungi 8(10):1037. https:\/\/doi.org\/10.3390\/jof8101037","journal-title":"J Fungi"},{"key":"4322_CR39","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.4252\/wjsc.v11.i12.1065","volume":"11","author":"N Chaicharoenaudomrung","year":"2019","unstructured":"Chaicharoenaudomrung N, Kunhorm P, Noisa P (2019) Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling. World J Stem Cells 11:1065\u20131083. https:\/\/doi.org\/10.4252\/wjsc.v11.i12.1065","journal-title":"World J Stem Cells"},{"issue":"16","key":"4322_CR40","doi-asserted-by":"publisher","first-page":"8362","DOI":"10.3390\/ijms22168362","volume":"22","author":"N Casagrande","year":"2021","unstructured":"Casagrande N, Borghese C, Gabbatore L, Morbiato L, De Zotti M, Aldinucci D (2021) Analogs of a natural peptaibol exert anticancer activity in both cisplatin- and doxorubicin-resistant cells and in multicellular tumor spheroids. Int J Mol Sci 22(16):8362. https:\/\/doi.org\/10.3390\/ijms22168362","journal-title":"Int J Mol Sci"},{"issue":"7","key":"4322_CR41","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1002\/jcb.25844","volume":"118","author":"MV Buri","year":"2017","unstructured":"Buri MV, Torquato HFV, Barros CC, Ide JS, Miranda A, Paredes-Gamero EJ (2017) Comparison of cytotoxic activity in leukemic lineages reveals important features of \u03b2-hairpin antimicrobial peptides. J Cell Biochem 118(7):1764\u20131773. https:\/\/doi.org\/10.1002\/jcb.25844","journal-title":"J Cell Biochem"},{"issue":"6","key":"4322_CR42","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/cbdv.200790095","volume":"4","author":"B Leitgeb","year":"2007","unstructured":"Leitgeb B, Szekeres A, Manczinger L, V\u00e1gv\u00f6lgyi C, Kredics L (2007) The history of alamethicin: a review of the most extensively studied peptaibol. Chem Biodivers 4(6):1027\u20131051. https:\/\/doi.org\/10.1002\/cbdv.200790095","journal-title":"Chem Biodivers"},{"key":"4322_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/10_2012_138","volume":"131","author":"YC Yong","year":"2013","unstructured":"Yong YC, Zhong JJ (2013) Impacts of quorum sensing on microbial metabolism and human health. Adv Biochem Eng Biotechnol 131:25\u201361. https:\/\/doi.org\/10.1007\/10_2012_138","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"12","key":"4322_CR44","doi-asserted-by":"publisher","first-page":"896","DOI":"10.3390\/antibiotics9120896","volume":"9","author":"N Szemer\u00e9di","year":"2020","unstructured":"Szemer\u00e9di N, Kincses A, Rehorova K, Hoang L, Salard\u00f3n-Jim\u00e9nez N, Sevilla-Hern\u00e1ndez C, Viktorov\u00e1 J, Dom\u00ednguez-\u00c1lvarez E, Spengler G (2020) Ketone- and cyano-selenoesters to overcome efflux pump, quorum-sensing, and biofilm-mediated resistance. Antibiotics 9(12):896. https:\/\/doi.org\/10.3390\/antibiotics9120896","journal-title":"Antibiotics"},{"key":"4322_CR45","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3390\/molecules21081013","volume":"21","author":"OA Pe\u00f1a-Mor\u00e1n","year":"2016","unstructured":"Pe\u00f1a-Mor\u00e1n OA, Villarreal ML, Alvarez L, Meneses-Acosta A, Rodr\u00edguez-L\u00f3pez V (2016) Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from Bursera fagaroides var. fagaroides on breast cancer cell lines. Molecules 21:1013. https:\/\/doi.org\/10.3390\/molecules21081013","journal-title":"Molecules"},{"key":"4322_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1476-4598-9-26","volume":"9","author":"M Shi","year":"2010","unstructured":"Shi M, Wang H-N, Xie S-T, Luo Y, Sun C-Y, Chen X-L, Zhang Y-Z (2010) Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol Cancer 9:26","journal-title":"Mol Cancer"},{"key":"4322_CR47","doi-asserted-by":"publisher","first-page":"45733","DOI":"10.1039\/C7RA09602J","volume":"7","author":"J Rivera-Ch\u00e1vez","year":"2017","unstructured":"Rivera-Ch\u00e1vez J, Raja HA, Graf TN, Gallagher JM, Metri P, Xue D, Pearce CJ, Oberlies NH (2017) Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: validation of their authenticity via in situ chemical analysis. RSC Adv 7:45733\u201345741","journal-title":"RSC Adv"},{"key":"4322_CR48","doi-asserted-by":"publisher","first-page":"127135","DOI":"10.1016\/j.bmcl.2020.127135","volume":"30","author":"I Kavianinia","year":"2020","unstructured":"Kavianinia I, Stubbing LA, Abbattista MR, Harris PW, Smaill JB, Patterson AV, Brimble MA (2020) Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibol. Bioorganic Med Chem Lett 30:127135","journal-title":"Bioorganic Med Chem Lett"},{"key":"4322_CR49","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2478\/acs-2019-0008","volume":"12","author":"J V\u00edgla\u0161","year":"2019","unstructured":"V\u00edgla\u0161 J, Olejn\u00edkov\u00e1 P (2019) Trichoderma atroviride: an isolate from forest environment with secondary metabolites with high antimicrobial potential. Acta Chim Slovaca 12:46\u201355. https:\/\/doi.org\/10.2478\/acs-2019-0008","journal-title":"Acta Chim Slovaca"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04322-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-025-04322-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04322-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T20:53:22Z","timestamp":1757192002000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-025-04322-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4322"],"URL":"https:\/\/doi.org\/10.1007\/s00284-025-04322-x","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"8 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential conflicts of interest was reported by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"342"}}