{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:49:08Z","timestamp":1775022548030,"version":"3.50.1"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00284-025-04336-5","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T23:12:15Z","timestamp":1751843535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Shared miRNA-mRNA Signature Network Between Helicobacter pylori Infection and Gastric Cancer: A Comparative Study"],"prefix":"10.1007","volume":"82","author":[{"given":"Amal","family":"Fahma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Subair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnapriya","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyas","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"issue":"1","key":"4336_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.5230\/jgc.2023.23.e10","volume":"23","author":"J Yoon","year":"2023","unstructured":"Yoon J, Kim TY, Oh DY (2023) Recent progress in immunotherapy for gastric cancer. J Gastric Cancer 23(1):207\u2013223. https:\/\/doi.org\/10.5230\/jgc.2023.23.e10","journal-title":"J Gastric Cancer"},{"key":"4336_CR2","doi-asserted-by":"publisher","first-page":"1327055","DOI":"10.3389\/fonc.2024.1327055","volume":"14","author":"H Li","year":"2024","unstructured":"Li H, Shen M, Wang S (2024) Current therapies and progress in the treatment of advanced gastric cancer. Front Oncol 14:1327055. https:\/\/doi.org\/10.3389\/fonc.2024.1327055","journal-title":"Front Oncol"},{"key":"4336_CR3","doi-asserted-by":"publisher","unstructured":"Riihimaki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K (2016) Metastatic spread in patients with gastric cancer. Oncotarget 7(32):52307\u201352316. https:\/\/doi.org\/10.18632\/oncotarget.10740","DOI":"10.18632\/oncotarget.10740"},{"key":"4336_CR4","doi-asserted-by":"publisher","unstructured":"Palrasu M, Zaika E, El-Rifai W, Que J, Zaika AI (2021) Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis. Cancers (Basel) 13(8). https:\/\/doi.org\/10.3390\/cancers13081878","DOI":"10.3390\/cancers13081878"},{"issue":"16","key":"4336_CR5","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","volume":"29","author":"WJ Yang","year":"2023","unstructured":"Yang WJ, Zhao HP, Yu Y, Wang JH, Guo L, Liu JY, Pu J, Lv J (2023) Updates on global epidemiology, risk and prognostic factors of gastric cancer. World J Gastroenterol 29(16):2452\u20132468. https:\/\/doi.org\/10.3748\/wjg.v29.i16.2452","journal-title":"World J Gastroenterol"},{"issue":"11","key":"4336_CR6","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","volume":"345","author":"N Uemura","year":"2001","unstructured":"Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345(11):784\u2013789. https:\/\/doi.org\/10.1056\/NEJMoa001999","journal-title":"N Engl J Med"},{"key":"4336_CR7","doi-asserted-by":"publisher","unstructured":"Shin WS, Xie F, Chen B, Yu J, Lo KW, Tse GMK, To KF, Kang W (2023) Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus. Cancers (Basel) 15(20). https:\/\/doi.org\/10.3390\/cancers15204993","DOI":"10.3390\/cancers15204993"},{"issue":"3","key":"4336_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1128\/CMR.00054-05","volume":"19","author":"JG Kusters","year":"2006","unstructured":"Kusters JG, van Vliet AH, Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19(3):449\u2013490. https:\/\/doi.org\/10.1128\/CMR.00054-05","journal-title":"Clin Microbiol Rev"},{"key":"4336_CR9","doi-asserted-by":"publisher","unstructured":"Parsonnet J (1995) Bacterial infection as a cause of cancer. Environ Health Perspect 103 Suppl 8(Suppl 8):263\u2013268. https:\/\/doi.org\/10.1289\/ehp.95103s8263","DOI":"10.1289\/ehp.95103s8263"},{"key":"4336_CR10","doi-asserted-by":"publisher","unstructured":"Kayali S, Manfredi M, Gaiani F, Bianchi L, Bizzarri B, Leandro G, Di Mario F, De' Angelis GL (2018) Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Biomed 89(8-S):72\u201376. https:\/\/doi.org\/10.23750\/abm.v89i8-S.7947","DOI":"10.23750\/abm.v89i8-S.7947"},{"issue":"Suppl","key":"4336_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/hel.12413","volume":"22","author":"M Venerito","year":"2017","unstructured":"Venerito M, Vasapolli R, Rokkas T, Delchier JC, Malfertheiner P (2017) Helicobacter pylori, gastric cancer and other gastrointestinal malignancies. Helicobacter 22(Suppl):1. https:\/\/doi.org\/10.1111\/hel.12413","journal-title":"Helicobacter"},{"issue":"5","key":"4336_CR12","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1128\/jcm.26.5.831-836.1988","volume":"26","author":"HL Mobley","year":"1988","unstructured":"Mobley HL, Cortesia MJ, Rosenthal LE, Jones BD (1988) Characterization of urease from Campylobacter pylori. J Clin Microbiol 26(5):831\u2013836. https:\/\/doi.org\/10.1128\/jcm.26.5.831-836.1988","journal-title":"J Clin Microbiol"},{"issue":"7","key":"4336_CR13","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1128\/iai.59.7.2470-2475.1991","volume":"59","author":"KA Eaton","year":"1991","unstructured":"Eaton KA, Brooks CL, Morgan DR, Krakowka S (1991) Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 59(7):2470\u20132475. https:\/\/doi.org\/10.1128\/iai.59.7.2470-2475.1991","journal-title":"Infect Immun"},{"issue":"1","key":"4336_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/s1286-4579(00)00285-9","volume":"2","author":"H Yoshiyama","year":"2000","unstructured":"Yoshiyama H, Nakazawa T (2000) Unique mechanism of Helicobacter pylori for colonizing the gastric mucus. Microbes Infect 2(1):55\u201360. https:\/\/doi.org\/10.1016\/s1286-4579(00)00285-9","journal-title":"Microbes Infect"},{"issue":"1","key":"4336_CR15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bj.2015.06.002","volume":"39","author":"CY Kao","year":"2016","unstructured":"Kao CY, Sheu BS, Wu JJ (2016) Helicobacter pylori infection: an overview of bacterial virulence factors and pathogenesis. Biomed J 39(1):14\u201323. https:\/\/doi.org\/10.1016\/j.bj.2015.06.002","journal-title":"Biomed J"},{"issue":"4","key":"4336_CR16","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1053\/j.gastro.2010.06.018","volume":"139","author":"J Wei","year":"2010","unstructured":"Wei J, Nagy TA, Vilgelm A, Zaika E, Ogden SR, Romero-Gallo J, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A (2010) Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology 139(4):1333\u20131343. https:\/\/doi.org\/10.1053\/j.gastro.2010.06.018","journal-title":"Gastroenterology"},{"key":"4336_CR17","doi-asserted-by":"publisher","unstructured":"Li N, Xie C, Lu NH (2016) p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis? Oncotarget 7(40):66276\u201366286. https:\/\/doi.org\/10.18632\/oncotarget.11414","DOI":"10.18632\/oncotarget.11414"},{"issue":"6","key":"4336_CR18","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrmicro3016","volume":"11","author":"NR Salama","year":"2013","unstructured":"Salama NR, Hartung ML, Muller A (2013) Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 11(6):385\u2013399. https:\/\/doi.org\/10.1038\/nrmicro3016","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"4336_CR19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.2183\/pjab.93.013","volume":"93","author":"M Hatakeyama","year":"2017","unstructured":"Hatakeyama M (2017) Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci 93(4):196\u2013219. https:\/\/doi.org\/10.2183\/pjab.93.013","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"4336_CR20","doi-asserted-by":"publisher","unstructured":"Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL (2016) An overview of Helicobacter pylori VacA Toxin Biology. Toxins (Basel) 8(6). https:\/\/doi.org\/10.3390\/toxins8060173","DOI":"10.3390\/toxins8060173"},{"key":"4336_CR21","doi-asserted-by":"publisher","unstructured":"Ito N, Tsujimoto H, Ueno H, Xie Q, Shinomiya N (2020) Helicobacter pylori-Mediated Immunity and Signaling Transduction in Gastric Cancer. J Clin Med 9(11). https:\/\/doi.org\/10.3390\/jcm9113699","DOI":"10.3390\/jcm9113699"},{"key":"4336_CR22","doi-asserted-by":"publisher","unstructured":"Smolarz B, Durczynski A, Romanowicz H, Szyllo K, Hogendorf P (2022) miRNAs in cancer (review of literature). Int J Mol Sci 23(5). https:\/\/doi.org\/10.3390\/ijms23052805","DOI":"10.3390\/ijms23052805"},{"key":"4336_CR23","doi-asserted-by":"publisher","unstructured":"Chiarella E, Aloisio A, Scicchitano S, Bond HM, Mesuraca M (2021) Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers. Int J Mol Sci 22(16). https:\/\/doi.org\/10.3390\/ijms22168461","DOI":"10.3390\/ijms22168461"},{"issue":"1","key":"4336_CR24","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41598-020-57834-w","volume":"10","author":"G Qin","year":"2020","unstructured":"Qin G, Mallik S, Mitra R, Li A, Jia P, Eischen CM, Zhao Z (2020) MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors. Sci Rep 10(1):852. https:\/\/doi.org\/10.1038\/s41598-020-57834-w","journal-title":"Sci Rep"},{"issue":"1","key":"4336_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12941","volume":"28","author":"P Ramesh","year":"2023","unstructured":"Ramesh P, Babu S, Ammankallu S, Codi JAK, Prasad TSK, Raju R (2023) Helicobacter pylori regulated microRNA map of human gastric cells. Helicobacter 28(1):e12941. https:\/\/doi.org\/10.1111\/hel.12941","journal-title":"Helicobacter"},{"key":"4336_CR26","doi-asserted-by":"publisher","unstructured":"Ouyang J, Xie Z, Lei X, Tang G, Gan R, Yang X (2021) Clinical crosstalk between microRNAs and gastric cancer (Review). Int J Oncol 58(4). https:\/\/doi.org\/10.3892\/ijo.2021.5187","DOI":"10.3892\/ijo.2021.5187"},{"issue":"7","key":"4336_CR27","doi-asserted-by":"publisher","first-page":"537","DOI":"10.2174\/138920210793175895","volume":"11","author":"LA Macfarlane","year":"2010","unstructured":"Macfarlane LA, Murphy PR (2010) MicroRNA: biogenesis, function and role in cancer. Curr Genomics 11(7):537\u2013561. https:\/\/doi.org\/10.2174\/138920210793175895","journal-title":"Curr Genomics"},{"issue":"1","key":"4336_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12885-016-3042-2","volume":"17","author":"A Salim","year":"2017","unstructured":"Salim A, Amjesh R, Chandra SS (2017) An approach to forecast human cancer by profiling microRNA expressions from NGS data. BMC Cancer 17(1):77. https:\/\/doi.org\/10.1186\/s12885-016-3042-2","journal-title":"BMC Cancer"},{"key":"4336_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107216","volume":"205","author":"H Xu","year":"2024","unstructured":"Xu H, Huang K, Shi M, Gong H, Han M, Tian W, Wang X, Zhang D (2024) MicroRNAs in Helicobacter pylori-infected gastric cancer: function and clinical application. Pharmacol Res 205:107216. https:\/\/doi.org\/10.1016\/j.phrs.2024.107216","journal-title":"Pharmacol Res"},{"key":"4336_CR30","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.3389\/fimmu.2017.01182","volume":"8","author":"RE Drury","year":"2017","unstructured":"Drury RE, O\u2019Connor D, Pollard AJ (2017) The clinical application of MicroRNAs in infectious disease. Front Immunol 8:1182. https:\/\/doi.org\/10.3389\/fimmu.2017.01182","journal-title":"Front Immunol"},{"key":"4336_CR31","doi-asserted-by":"publisher","unstructured":"Sasaran MO, Melit LE, Dobru ED (2021) MicroRNA modulation of host immune response and inflammation triggered by Helicobacter pylori. Int J Mol Sci 22(3). https:\/\/doi.org\/10.3390\/ijms22031406","DOI":"10.3390\/ijms22031406"},{"key":"4336_CR32","doi-asserted-by":"publisher","unstructured":"Zabaleta J (2012) MicroRNA: a bridge from H. pylori infection to gastritis and gastric cancer development. Front Genet 3:294. https:\/\/doi.org\/10.3389\/fgene.2012.00294","DOI":"10.3389\/fgene.2012.00294"},{"issue":"20","key":"4336_CR33","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.3748\/wjg.v19.i20.2985","volume":"19","author":"J Raisch","year":"2013","unstructured":"Raisch J, Darfeuille-Michaud A, Nguyen HT (2013) Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol 19(20):2985\u20132996. https:\/\/doi.org\/10.3748\/wjg.v19.i20.2985","journal-title":"World J Gastroenterol"},{"key":"4336_CR34","doi-asserted-by":"publisher","unstructured":"Na HK, Woo JH (2014) Helicobacter pylori induces hypermethylation of CpG islands through upregulation of DNA methyltransferase: possible involvement of reactive oxygen\/nitrogen species. J Cancer Prev 19(4):259\u2013264. https:\/\/doi.org\/10.15430\/JCP.2014.19.4.259","DOI":"10.15430\/JCP.2014.19.4.259"},{"issue":"1","key":"4336_CR35","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41419-017-0020-9","volume":"9","author":"F Yang","year":"2018","unstructured":"Yang F, Xu Y, Liu C, Ma C, Zou S, Xu X, Jia J, Liu Z (2018) NF-kappaB\/miR-223-3p\/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression. Cell Death Dis 9(1):12. https:\/\/doi.org\/10.1038\/s41419-017-0020-9","journal-title":"Cell Death Dis"},{"key":"4336_CR36","doi-asserted-by":"publisher","unstructured":"Sun F, Ni Y, Zhu H, Fang J, Wang H, Xia J, Ding F, Shen H, Shao S (2018) microRNA-29a-3p, Up-regulated in human gastric cells and tissues with H. Pylori infection, promotes the migration of GES-1 cells via A20-mediated EMT pathway. Cell Physiol Biochem 51(3):1250\u20131263. https:\/\/doi.org\/10.1159\/000495502","DOI":"10.1159\/000495502"},{"key":"4336_CR37","doi-asserted-by":"publisher","unstructured":"Song Y, Guo D, Liu JF, Ge LN, Liu P, Qu YM, Cong HY, Li T, Chang X, Wang YR, Shao LY, Du ZJ, Wang MY (2023) Downregulation of miR\u20117 and miR\u2011153 is involved in Helicobacter\u00a0pylori CagA induced gastric carcinogenesis and progression. Int J Oncol 63(1):79. https:\/\/doi.org\/10.3892\/ijo.2023.5527","DOI":"10.3892\/ijo.2023.5527"},{"key":"4336_CR38","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.1038\/sigtrans.2015.4","volume":"1","author":"Y Peng","year":"2016","unstructured":"Peng Y, Croce CM (2016) The role of MicroRNAs in human cancer. Signal Transduct Target Ther 1:15004. https:\/\/doi.org\/10.1038\/sigtrans.2015.4","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"4336_CR39","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1089\/omi.2024.0071","volume":"28","author":"K Ramakrishnan","year":"2024","unstructured":"Ramakrishnan K, Vishwakarma R, Dev RR, Raju R, Rehman N (2024) Etiologically significant microRNAs in Hepatitis B virus-induced hepatocellular carcinoma. OMICS 28(6):280\u2013290. https:\/\/doi.org\/10.1089\/omi.2024.0071","journal-title":"OMICS"},{"issue":"1","key":"4336_CR40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4068\/cmj.2024.60.1.21","volume":"60","author":"A Alizamir","year":"2024","unstructured":"Alizamir A, Amini MA, Karbasi A, Beyrami M (2024) MiR-4492, a new potential MicroRNA for cancer diagnosis and treatment: a mini review. Chonnam Med J 60(1):21\u201326. https:\/\/doi.org\/10.4068\/cmj.2024.60.1.21","journal-title":"Chonnam Med J"},{"issue":"1","key":"4336_CR41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE (2002) Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30(1):207\u2013210. https:\/\/doi.org\/10.1093\/nar\/30.1.207","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4336_CR42","doi-asserted-by":"publisher","first-page":"D155","DOI":"10.1093\/nar\/gky1141","volume":"47","author":"A Kozomara","year":"2019","unstructured":"Kozomara A, Birgaoanu M, Griffiths-Jones S (2019) miRBase: from microRNA sequences to function. Nucleic Acids Res 47(D1):D155\u2013D162. https:\/\/doi.org\/10.1093\/nar\/gky1141","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4336_CR43","doi-asserted-by":"publisher","first-page":"D148","DOI":"10.1093\/nar\/gkz896","volume":"48","author":"HY Huang","year":"2020","unstructured":"Huang HY, Lin YC, Li J, Huang KY, Shrestha S, Hong HC, Tang Y, Chen YG, Jin CN, Yu Y, Xu JT, Li YM, Cai XX, Zhou ZY, Chen XH, Pei YY, Hu L, Su JJ, Cui SD, Wang F, Xie YY, Ding SY, Luo MF, Chou CH, Chang NW, Chen KW, Cheng YH, Wan XH, Hsu WL, Lee TY, Wei FX, Huang HD (2020) miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database. Nucleic Acids Res 48(D1):D148\u2013D154. https:\/\/doi.org\/10.1093\/nar\/gkz896","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4336_CR44","doi-asserted-by":"publisher","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","volume":"46","author":"D Karagkouni","year":"2018","unstructured":"Karagkouni D, Paraskevopoulou MD, Chatzopoulos S, Vlachos IS, Tastsoglou S, Kanellos I, Papadimitriou D, Kavakiotis I, Maniou S, Skoufos G, Vergoulis T, Dalamagas T, Hatzigeorgiou AG (2018) DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA-gene interactions. Nucleic Acids Res 46(D1):D239\u2013D245. https:\/\/doi.org\/10.1093\/nar\/gkx1141","journal-title":"Nucleic Acids Res"},{"key":"4336_CR45","doi-asserted-by":"publisher","unstructured":"Tong Z, Cui Q, Wang J, Zhou Y (2019) TransmiR v2.0: an updated transcription factor-microRNA regulation database. Nucleic Acids Res 47(D1):D253\u2013D258. https:\/\/doi.org\/10.1093\/nar\/gky1023","DOI":"10.1093\/nar\/gky1023"},{"issue":"11","key":"4336_CR46","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"issue":"8","key":"4336_CR47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1507","volume":"44","author":"A Colaprico","year":"2016","unstructured":"Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, Ceccarelli M, Bontempi G, Noushmehr H (2016) TCGAbiolinks: an R\/bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res 44(8):e71. https:\/\/doi.org\/10.1093\/nar\/gkv1507","journal-title":"Nucleic Acids Res"},{"key":"4336_CR48","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3389\/fimmu.2017.01288","volume":"8","author":"M Pagliari","year":"2017","unstructured":"Pagliari M, Munari F, Toffoletto M, Lonardi S, Chemello F, Codolo G, Millino C, Della Bella C, Pacchioni B, Vermi W, Fassan M, de Bernard M, Cagnin S (2017) Helicobacter pylori affects the antigen presentation activity of macrophages modulating the expression of the immune receptor CD300E through miR-4270. Front Immunol 8:1288. https:\/\/doi.org\/10.3389\/fimmu.2017.01288","journal-title":"Front Immunol"},{"key":"4336_CR49","unstructured":"Zhang Y-M, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Jr., Smolka AJ (2014) Helicobacter pylori-induced changes in miRNA expression in human gastric epithelial cells"},{"issue":"4","key":"4336_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035147","volume":"7","author":"Y Zhu","year":"2012","unstructured":"Zhu Y, Jiang Q, Lou X, Ji X, Wen Z, Wu J, Tao H, Jiang T, He W, Wang C, Du Q, Zheng S, Mao J, Huang J (2012) MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells. PLoS ONE 7(4):e35147. https:\/\/doi.org\/10.1371\/journal.pone.0035147","journal-title":"PLoS ONE"},{"issue":"2","key":"4336_CR51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/cas.13462","volume":"109","author":"G Teng","year":"2018","unstructured":"Teng G, Dai Y, Chu Y, Li J, Zhang H, Wu T, Shuai X, Wang W (2018) Helicobacter pylori induces caudal-type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells. Cancer Sci 109(2):297\u2013307. https:\/\/doi.org\/10.1111\/cas.13462","journal-title":"Cancer Sci"},{"issue":"2","key":"4336_CR52","doi-asserted-by":"publisher","first-page":"262","DOI":"10.4149\/neo_2020_200806N823","volume":"68","author":"J Liu","year":"2021","unstructured":"Liu J, Wang L, Li J, Xu Y (2021) Upregulation of microRNA-650 by PBX1 is correlated with the development of Helicobacter pylori-associated gastric carcinoma. Neoplasma 68(2):262\u2013272. https:\/\/doi.org\/10.4149\/neo_2020_200806N823","journal-title":"Neoplasma"},{"issue":"1\u20132","key":"4336_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2023.105236","volume":"26","author":"J Li","year":"2024","unstructured":"Li J, Li X, Zhang Z, Wang S, Huang X, Min L, Li P (2024) Helicobacter pylori promotes gastric fibroblast proliferation and migration by expulsing exosomal miR-124-3p. Microbes Infect 26(1\u20132):105236. https:\/\/doi.org\/10.1016\/j.micinf.2023.105236","journal-title":"Microbes Infect"},{"issue":"3","key":"4336_CR54","doi-asserted-by":"publisher","first-page":"392","DOI":"10.5009\/gnl16265","volume":"11","author":"JW Chung","year":"2017","unstructured":"Chung JW, Jeong SH, Lee SM, Pak JH, Lee GH, Jeong JY, Kim JH (2017) Expression of MicroRNA in host cells infected with Helicobacter pylori. Gut Liver 11(3):392\u2013400. https:\/\/doi.org\/10.5009\/gnl16265","journal-title":"Gut Liver"},{"issue":"5","key":"4336_CR55","doi-asserted-by":"publisher","first-page":"571","DOI":"10.5009\/gnl19299","volume":"14","author":"JM Choi","year":"2020","unstructured":"Choi JM, Kim SG, Yang HJ, Lim JH, Cho NY, Kim WH, Kim JS, Jung HC (2020) Helicobacter pylori eradication can reverse the methylation-associated regulation of miR-200a\/b in gastric carcinogenesis. Gut Liver 14(5):571\u2013580. https:\/\/doi.org\/10.5009\/gnl19299","journal-title":"Gut Liver"},{"issue":"11","key":"4336_CR56","doi-asserted-by":"publisher","first-page":"G786","DOI":"10.1152\/ajpgi.00279.2013","volume":"305","author":"JM Noto","year":"2013","unstructured":"Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM Jr (2013) Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol 305(11):G786-796. https:\/\/doi.org\/10.1152\/ajpgi.00279.2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4336_CR57","doi-asserted-by":"publisher","unstructured":"Zhou X, Xu G, Yin C, Jin W, Zhang G (2014) Down-regulation of miR-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK. Oncotarget 5(22):11631\u201311640. https:\/\/doi.org\/10.18632\/oncotarget.2600","DOI":"10.18632\/oncotarget.2600"},{"issue":"1","key":"4336_CR58","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4161\/15384047.2014.987523","volume":"16","author":"X Zhou","year":"2015","unstructured":"Zhou X, Xia Y, Li L, Zhang G (2015) MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2. Cancer Biol Ther 16(1):160\u2013169. https:\/\/doi.org\/10.4161\/15384047.2014.987523","journal-title":"Cancer Biol Ther"},{"issue":"9","key":"4336_CR59","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1158\/1078-0432.CCR-10-3152","volume":"17","author":"HK Oh","year":"2011","unstructured":"Oh HK, Tan AL, Das K, Ooi CH, Deng NT, Tan IB, Beillard E, Lee J, Ramnarayanan K, Rha SY, Palanisamy N, Voorhoeve PM, Tan P (2011) Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. Clin Cancer Res 17(9):2657\u20132667. https:\/\/doi.org\/10.1158\/1078-0432.CCR-10-3152","journal-title":"Clin Cancer Res"},{"issue":"41","key":"4336_CR60","doi-asserted-by":"publisher","first-page":"7078","DOI":"10.3748\/wjg.v19.i41.7078","volume":"19","author":"JY Lim","year":"2013","unstructured":"Lim JY, Yoon SO, Seol SY, Hong SW, Kim JW, Choi SH, Lee JS, Cho JY (2013) Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype. World J Gastroenterol 19(41):7078\u20137088. https:\/\/doi.org\/10.3748\/wjg.v19.i41.7078","journal-title":"World J Gastroenterol"},{"issue":"1","key":"4336_CR61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/path.4032","volume":"228","author":"J Carvalho","year":"2012","unstructured":"Carvalho J, van Grieken NC, Pereira PM, Sousa S, Tijssen M, Buffart TE, Diosdado B, Grabsch H, Santos MA, Meijer G, Seruca R, Carvalho B, Oliveira C (2012) Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer. J Pathol 228(1):31\u201344. https:\/\/doi.org\/10.1002\/path.4032","journal-title":"J Pathol"},{"issue":"2","key":"4336_CR62","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5009\/gnl13371","volume":"9","author":"H Chang","year":"2015","unstructured":"Chang H, Kim N, Park JH, Nam RH, Choi YJ, Lee HS, Yoon H, Shin CM, Park YS, Kim JM, Lee DH (2015) Different microRNA expression levels in gastric cancer depending on Helicobacter pylori infection. Gut Liver 9(2):188\u2013196. https:\/\/doi.org\/10.5009\/gnl13371","journal-title":"Gut Liver"},{"issue":"2","key":"4336_CR63","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/bjc.2017.190","volume":"117","author":"M Sierzega","year":"2017","unstructured":"Sierzega M, Kaczor M, Kolodziejczyk P, Kulig J, Sanak M, Richter P (2017) Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. Br J Cancer 117(2):266\u2013273. https:\/\/doi.org\/10.1038\/bjc.2017.190","journal-title":"Br J Cancer"},{"issue":"1","key":"4336_CR64","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41467-017-00304-1","volume":"8","author":"YX Song","year":"2017","unstructured":"Song YX, Sun JX, Zhao JH, Yang YC, Shi JX, Wu ZH, Chen XW, Gao P, Miao ZF, Wang ZN (2017) Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. Nat Commun 8(1):289. https:\/\/doi.org\/10.1038\/s41467-017-00304-1","journal-title":"Nat Commun"},{"key":"4336_CR65","doi-asserted-by":"publisher","first-page":"1136096","DOI":"10.3389\/fcell.2023.1136096","volume":"11","author":"H Li","year":"2023","unstructured":"Li H, Lin J, Cheng S, Chi J, Luo J, Tang Y, Zhao W, Shu Y, Liu X, Xu C (2023) Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection. Front Cell Dev Biol 11:1136096. https:\/\/doi.org\/10.3389\/fcell.2023.1136096","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"4336_CR66","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.celrep.2015.05.030","volume":"11","author":"M Koeppel","year":"2015","unstructured":"Koeppel M, Garcia-Alcalde F, Glowinski F, Schlaermann P, Meyer TF (2015) Helicobacter pylori infection causes characteristic DNA damage patterns in human cells. Cell Rep 11(11):1703\u20131713. https:\/\/doi.org\/10.1016\/j.celrep.2015.05.030","journal-title":"Cell Rep"},{"key":"4336_CR67","doi-asserted-by":"publisher","unstructured":"Kontizas E, Tastsoglou S, Karamitros T, Karayiannis Y, Kollia P, Hatzigeorgiou AG, Sgouras DN (2020) Impact of Helicobacter pylori infection and its major virulence factor CagA on DNA damage repair. Microorganisms 8(12). https:\/\/doi.org\/10.3390\/microorganisms8122007","DOI":"10.3390\/microorganisms8122007"},{"issue":"3","key":"4336_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2022.100032","volume":"1","author":"I Sharafutdinov","year":"2022","unstructured":"Sharafutdinov I, Ekici A, Vieth M, Backert S, Linz B (2022) Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacter pylori. Cell Insight 1(3):100032. https:\/\/doi.org\/10.1016\/j.cellin.2022.100032","journal-title":"Cell Insight"},{"issue":"11","key":"4336_CR69","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/infdis\/jiw031","volume":"213","author":"AM Costa","year":"2016","unstructured":"Costa AM, Ferreira RM, Pinto-Ribeiro I, Sougleri IS, Oliveira MJ, Carreto L, Santos MA, Sgouras DN, Carneiro F, Leite M, Figueiredo C (2016) Helicobacter pylori activates matrix metalloproteinase 10 in gastric epithelial cells via EGFR and ERK-mediated pathways. J Infect Dis 213(11):1767\u20131776. https:\/\/doi.org\/10.1093\/infdis\/jiw031","journal-title":"J Infect Dis"},{"key":"4336_CR70","unstructured":"Glowinski F, Okonechnikov K, Garcia-Alcalde F, Meyer TF (2015) Transcriptome analysis of AGS cells infected with Helicobacter pylori P12"},{"issue":"37","key":"4336_CR71","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.3748\/wjg.v23.i37.6817","volume":"23","author":"MT Cairns","year":"2017","unstructured":"Cairns MT, Gupta A, Naughton JA, Kane M, Clyne M, Joshi L (2017) Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori. World J Gastroenterol 23(37):6817\u20136832. https:\/\/doi.org\/10.3748\/wjg.v23.i37.6817","journal-title":"World J Gastroenterol"},{"key":"4336_CR72","unstructured":"Yue GX, Tian W, Zhu P, Liu Y, Wu J, Chen W, Wang P, Xu J, Liu S, L\u00fc M, Yang S, Liu T, Cheng P, Mao F, Teng Y, Luo S, Zhang J, Peng L, Zou Q, Liao Y, Yang S, Zhao Y, Zhou H, Chen W, You N, Xie R, Zhuang Y (2024) Expression data from AGS cells with Helicobacter pylori infection"},{"issue":"3","key":"4336_CR73","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10120-019-01029-4","volume":"23","author":"SK Kim","year":"2020","unstructured":"Kim SK, Kim HJ, Park JL, Heo H, Kim SY, Lee SI, Song KS, Kim WH, Kim YS (2020) Identification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer. Gastric Cancer 23(3):473\u2013482. https:\/\/doi.org\/10.1007\/s10120-019-01029-4","journal-title":"Gastric Cancer"},{"key":"4336_CR74","unstructured":"Zhu M, Zn, Ma J (2023) Next generation sequencing of expression and differentially expression of miRNAs, lncRNAs and circRNAs in gastric adenocarcinoma"},{"issue":"3","key":"4336_CR75","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ejca.2008.10.032","volume":"45","author":"M D'Errico","year":"2009","unstructured":"D\u2019Errico M, de Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, Palombo F, Giuliani A, Dogliotti E (2009) Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur J Cancer 45(3):461\u2013469. https:\/\/doi.org\/10.1016\/j.ejca.2008.10.032","journal-title":"Eur J Cancer"},{"issue":"1","key":"4336_CR76","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/cam4.311","volume":"4","author":"A Ema","year":"2015","unstructured":"Ema A, Waraya M, Yamashita K, Kokubo K, Kobayashi H, Hoshi K, Shinkai Y, Kawamata H, Nakamura K, Nishimiya H, Katada N, Watanabe M (2015) Identification of EGFR expression status association with metastatic lymph node density (ND) by expression microarray analysis of advanced gastric cancer. Cancer Med 4(1):90\u2013100. https:\/\/doi.org\/10.1002\/cam4.311","journal-title":"Cancer Med"},{"key":"4336_CR77","unstructured":"Humans IWGotEoCRt (2012) Biological agents. IARC Monogr Eval Carcinog Risks Hum 100(Pt B):1\u2013441"},{"issue":"4","key":"4336_CR78","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/bies.200800212","volume":"31","author":"NJ Martinez","year":"2009","unstructured":"Martinez NJ, Walhout AJ (2009) The interplay between transcription factors and microRNAs in genome-scale regulatory networks. BioEssays 31(4):435\u2013445. https:\/\/doi.org\/10.1002\/bies.200800212","journal-title":"BioEssays"},{"issue":"12","key":"4336_CR79","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1089\/omi.2023.0171","volume":"27","author":"K Ramakrishnan","year":"2023","unstructured":"Ramakrishnan K, Babu S, Shaji V, Soman S, Leelamma A, Rehman N, Raju R (2023) Hepatitis B virus modulated transcriptional regulatory map of hepatic cellular MicroRNAs. OMICS 27(12):581\u2013597. https:\/\/doi.org\/10.1089\/omi.2023.0171","journal-title":"OMICS"},{"issue":"4","key":"4336_CR80","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrm2868","volume":"11","author":"M Inui","year":"2010","unstructured":"Inui M, Martello G, Piccolo S (2010) MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11(4):252\u2013263. https:\/\/doi.org\/10.1038\/nrm2868","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"4336_CR81","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg2843","volume":"11","author":"J Krol","year":"2010","unstructured":"Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 11(9):597\u2013610. https:\/\/doi.org\/10.1038\/nrg2843","journal-title":"Nat Rev Genet"},{"key":"4336_CR82","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1752-0509-6-18","volume":"6","author":"CC Lin","year":"2012","unstructured":"Lin CC, Chen YJ, Chen CY, Oyang YJ, Juan HF, Huang HC (2012) Crosstalk between transcription factors and microRNAs in human protein interaction network. BMC Syst Biol 6:18. https:\/\/doi.org\/10.1186\/1752-0509-6-18","journal-title":"BMC Syst Biol"},{"key":"4336_CR83","doi-asserted-by":"publisher","unstructured":"Cheng S, Ray D, Lee RTH, Naripogu KB, Yusoff P, Goh PBL, Liu Y, Suzuki Y, Das K, Chan HS, Wong WK, Chan WH, Chow PK, Ong HS, Raj P, Soo KC, Tan P, Epstein DM, Rozen SG (2020) A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors. NAR Genom Bioinform 2(2):lqaa013. https:\/\/doi.org\/10.1093\/nargab\/lqaa013","DOI":"10.1093\/nargab\/lqaa013"},{"key":"4336_CR84","doi-asserted-by":"publisher","unstructured":"Shen C, Song YH, Xie Y, Wang X, Wang Y, Wang C, Liu S, Xue SL, Li Y, Liu B, Tang Z, Chen W, Song J, Amin HM, Zhou J (2017) Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. Oncotarget 8(44):76279\u201376289. https:\/\/doi.org\/10.18632\/oncotarget.19348","DOI":"10.18632\/oncotarget.19348"},{"key":"4336_CR85","doi-asserted-by":"publisher","first-page":"153303382093547","DOI":"10.1177\/1533033820935477","volume":"19","author":"RE Sexton","year":"2020","unstructured":"Sexton RE, Hallak MNA, Uddin MH, Diab M, Azmi AS (2020) Gastric cancer heterogeneity and clinical outcomes. Technol Cancer Res Treat 19:1533033820935477. https:\/\/doi.org\/10.1177\/1533033820935477","journal-title":"Technol Cancer Res Treat"},{"issue":"Suppl 1","key":"4336_CR86","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1111\/j.1523-5378.1997.06b03.x","volume":"2","author":"D Palli","year":"1997","unstructured":"Palli D (1997) Gastric cancer and Helicobacter pylori: a critical evaluation of the epidemiological evidence. Helicobacter 2(Suppl 1):S50-55. https:\/\/doi.org\/10.1111\/j.1523-5378.1997.06b03.x","journal-title":"Helicobacter"},{"issue":"3","key":"4336_CR87","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.cgh.2019.07.045","volume":"18","author":"AP Thrift","year":"2020","unstructured":"Thrift AP, El-Serag HB (2020) Burden of gastric cancer. Clin Gastroenterol Hepatol 18(3):534\u2013542. https:\/\/doi.org\/10.1016\/j.cgh.2019.07.045","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"4336_CR88","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1158\/1078-0432.CCR-17-2376","volume":"24","author":"X Chen","year":"2018","unstructured":"Chen X, Chen Z, Yu S, Nie F, Yan S, Ma P, Chen Q, Wei C, Fu H, Xu T, Ren S, Sun M, Wang Z (2018) Long noncoding RNA LINC01234 functions as a competing endogenous RNA to regulate CBFB Expression by sponging miR-204-5p in gastric cancer. Clin Cancer Res 24(8):2002\u20132014. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-2376","journal-title":"Clin Cancer Res"},{"issue":"32","key":"4336_CR89","doi-asserted-by":"publisher","first-page":"11755","DOI":"10.1073\/pnas.0404432101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupo S, Dono M, Dell\u2019Aquila ML, Alder H, Rassenti L, Kipps TJ, Bullrich F, Negrini M, Croce CM (2004) MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 101(32):11755\u201311760. https:\/\/doi.org\/10.1073\/pnas.0404432101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4336_CR90","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12935-024-03386-2","volume":"24","author":"V Hazari","year":"2024","unstructured":"Hazari V, Samali SA, Izadpanahi P, Mollaei H, Sadri F, Rezaei Z (2024) MicroRNA-98: the multifaceted regulator in human cancer progression and therapy. Cancer Cell Int 24(1):209. https:\/\/doi.org\/10.1186\/s12935-024-03386-2","journal-title":"Cancer Cell Int"},{"key":"4336_CR91","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.2147\/OTT.S163771","volume":"11","author":"Y Jiang","year":"2018","unstructured":"Jiang Y, Zhang M, Guo T, Yang C, Zhang C, Hao J (2018) MicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7. Onco Targets Ther 11:4901\u20134911. https:\/\/doi.org\/10.2147\/OTT.S163771","journal-title":"Onco Targets Ther"},{"issue":"7","key":"4336_CR92","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1073\/pnas.0510565103","volume":"103","author":"S Volinia","year":"2006","unstructured":"Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103(7):2257\u20132261. https:\/\/doi.org\/10.1073\/pnas.0510565103","journal-title":"Proc Natl Acad Sci USA"},{"key":"4336_CR93","doi-asserted-by":"publisher","unstructured":"Ma Y, Shen N, Wicha MS, Luo M (2021) The roles of the Let-7 family of MicroRNAs in the regulation of cancer stemness. Cells 10(9). https:\/\/doi.org\/10.3390\/cells10092415","DOI":"10.3390\/cells10092415"},{"key":"4336_CR94","doi-asserted-by":"publisher","first-page":"10539","DOI":"10.2147\/CMAR.S221585","volume":"11","author":"X Sun","year":"2019","unstructured":"Sun X, Xue H, Xiong Y, Yu R, Gao X, Qian M, Wang S, Wang H, Xu J, Chen Z, Deng L, Li G (2019) GALE promotes the proliferation and migration of glioblastoma cells and is regulated by miR-let-7i-5p. Cancer Manag Res 11:10539\u201310554. https:\/\/doi.org\/10.2147\/CMAR.S221585","journal-title":"Cancer Manag Res"},{"issue":"1","key":"4336_CR95","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12894-021-00820-9","volume":"21","author":"Y Liu","year":"2021","unstructured":"Liu Y, Hu X, Hu L, Xu C, Liang X (2021) Let-7i-5p enhances cell proliferation, migration and invasion of ccRCC by targeting HABP4. BMC Urol 21(1):49. https:\/\/doi.org\/10.1186\/s12894-021-00820-9","journal-title":"BMC Urol"},{"issue":"1","key":"4336_CR96","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12935-023-02871-4","volume":"23","author":"H Wang","year":"2023","unstructured":"Wang H, Yuan H, Guo Q, Zeng X, Liu M, Ji R, Chen Z, Guan Q, Zheng Y, Wang Y, Zhou Y (2023) A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression. Cancer Cell Int 23(1):35. https:\/\/doi.org\/10.1186\/s12935-023-02871-4","journal-title":"Cancer Cell Int"},{"key":"4336_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110517","volume":"101","author":"J Deng","year":"2023","unstructured":"Deng J, Wang H, Liang Y, Zhao L, Li Y, Yan Y, Zhao H, Zhang X, Zou F (2023) miR-15a-5p enhances the malignant phenotypes of colorectal cancer cells through the STAT3\/TWIST1 and PTEN\/AKT signaling pathways by targeting SIRT4. Cell Signal 101:110517. https:\/\/doi.org\/10.1016\/j.cellsig.2022.110517","journal-title":"Cell Signal"},{"key":"4336_CR98","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.2147\/CMAR.S262245","volume":"12","author":"HC Rao","year":"2020","unstructured":"Rao HC, Wu ZK, Wei SD, Jiang Y, Guo QX, Wang JW, Chen CX, Yang HY (2020) MiR-25-3p serves as an oncogenic MicroRNA by downregulating the expression of merlin in osteosarcoma. Cancer Manag Res 12:8989\u20139001. https:\/\/doi.org\/10.2147\/CMAR.S262245","journal-title":"Cancer Manag Res"},{"issue":"1","key":"4336_CR99","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/21655979.2019.1710924","volume":"11","author":"L Ning","year":"2020","unstructured":"Ning L, Zhang M, Zhu Q, Hao F, Shen W, Chen D (2020) miR-25-3p inhibition impairs tumorigenesis and invasion in gastric cancer cells in vitro and in vivo. Bioengineered 11(1):81\u201390. https:\/\/doi.org\/10.1080\/21655979.2019.1710924","journal-title":"Bioengineered"},{"issue":"3","key":"4336_CR100","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1002\/cam4.5077","volume":"12","author":"F Yang","year":"2023","unstructured":"Yang F, Bian Z, Xu P, Sun S, Huang Z (2023) MicroRNA-204-5p: a pivotal tumor suppressor. Cancer Med 12(3):3185\u20133200. https:\/\/doi.org\/10.1002\/cam4.5077","journal-title":"Cancer Med"},{"issue":"5","key":"4336_CR101","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5306\/wjco.v6.i5.111","volume":"6","author":"D Libanio","year":"2015","unstructured":"Libanio D, Dinis-Ribeiro M, Pimentel-Nunes P (2015) Helicobacter pylori and microRNAs: relation with innate immunity and progression of preneoplastic conditions. World J Clin Oncol 6(5):111\u2013132. https:\/\/doi.org\/10.5306\/wjco.v6.i5.111","journal-title":"World J Clin Oncol"},{"issue":"2","key":"4336_CR102","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/ijc.25348","volume":"128","author":"K Matsushima","year":"2011","unstructured":"Matsushima K, Isomoto H, Inoue N, Nakayama T, Hayashi T, Nakayama M, Nakao K, Hirayama T, Kohno S (2011) MicroRNA signatures in Helicobacter pylori-infected gastric mucosa. Int J Cancer 128(2):361\u2013370. https:\/\/doi.org\/10.1002\/ijc.25348","journal-title":"Int J Cancer"},{"issue":"3","key":"4336_CR103","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1006\/bbrc.1996.0961","volume":"223","author":"PJ Vredendaal","year":"1996","unstructured":"Vredendaal PJ, van den Berg IE, Malingre HE, Stroobants AK, Olde Weghuis DE, Berger R (1996) Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence. Biochem Biophys Res Commun 223(3):718\u2013723. https:\/\/doi.org\/10.1006\/bbrc.1996.0961","journal-title":"Biochem Biophys Res Commun"},{"issue":"43","key":"4336_CR104","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1038\/s41388-023-02838-9","volume":"42","author":"R Advani","year":"2023","unstructured":"Advani R, Luzzi S, Scott E, Dalgliesh C, Weischenfeldt J, Munkley J, Elliott DJ (2023) Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer. Oncogene 42(43):3161\u20133168. https:\/\/doi.org\/10.1038\/s41388-023-02838-9","journal-title":"Oncogene"},{"issue":"4","key":"4336_CR105","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1093\/bib\/bby018","volume":"20","author":"J Yang","year":"2019","unstructured":"Yang J, Song H, Cao K, Song J, Zhou J (2019) Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network. Brief Bioinform 20(4):1492\u20131501. https:\/\/doi.org\/10.1093\/bib\/bby018","journal-title":"Brief Bioinform"},{"issue":"3","key":"4336_CR106","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3892\/ol.2022.13209","volume":"23","author":"P Zhao","year":"2022","unstructured":"Zhao P, Ma X, Cheng J, Chen H, Li L (2022) Identification of the hub genes and transcription factor-miRNA axes involved in Helicobacter pylori-associated gastric cancer. Oncol Lett 23(3):89. https:\/\/doi.org\/10.3892\/ol.2022.13209","journal-title":"Oncol Lett"},{"key":"4336_CR107","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.2147\/CMAR.S232388","volume":"12","author":"Y Wang","year":"2020","unstructured":"Wang Y, Zeng G, Jiang Y (2020) The emerging roles of miR-125b in cancers. Cancer Manag Res 12:1079\u20131088. https:\/\/doi.org\/10.2147\/CMAR.S232388","journal-title":"Cancer Manag Res"},{"issue":"5","key":"4336_CR108","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1002\/hep.26514","volume":"58","author":"K Song","year":"2013","unstructured":"Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, Wu T (2013) Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells. Hepatology 58(5):1681\u20131692. https:\/\/doi.org\/10.1002\/hep.26514","journal-title":"Hepatology"},{"issue":"1","key":"4336_CR109","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3892\/etm.2017.4548","volume":"14","author":"M Sui","year":"2017","unstructured":"Sui M, Jiao A, Zhai H, Wang Y, Wang Y, Sun D, Li P (2017) Upregulation of miR-125b is associated with poor prognosis and trastuzumab resistance in HER2-positive gastric cancer. Exp Ther Med 14(1):657\u2013663. https:\/\/doi.org\/10.3892\/etm.2017.4548","journal-title":"Exp Ther Med"},{"issue":"6","key":"4336_CR110","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.stemcr.2016.05.007","volume":"6","author":"D Djeghloul","year":"2016","unstructured":"Djeghloul D, Kuranda K, Kuzniak I, Barbieri D, Naguibneva I, Choisy C, Bories JC, Dosquet C, Pla M, Vanneaux V, Socie G, Porteu F, Garrick D, Goodhardt M (2016) Age-associated decrease of the histone methyltransferase SUV39H1 in HSC perturbs heterochromatin and B lymphoid differentiation. Stem Cell Reports 6(6):970\u2013984. https:\/\/doi.org\/10.1016\/j.stemcr.2016.05.007","journal-title":"Stem Cell Reports"},{"issue":"5","key":"4336_CR111","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/15384047.2018.1423925","volume":"19","author":"X Xu","year":"2018","unstructured":"Xu X, Gao F, Wang J, Tao L, Ye J, Ding L, Ji W, Chen X (2018) MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4. Cancer Biol Ther 19(5):427\u2013435. https:\/\/doi.org\/10.1080\/15384047.2018.1423925","journal-title":"Cancer Biol Ther"},{"issue":"Suppl1","key":"4336_CR112","first-page":"S1","volume":"14","author":"N Amiri-Dashatan","year":"2021","unstructured":"Amiri-Dashatan N, Koushki M, Naghi-Zadeh M, Razzaghi MR, Mohaghegh Shalmani H (2021) Prognostic value of microRNA-125a\/b family in patients with gastric cancer: a meta-analysis. Gastroenterol Hepatol Bed Bench 14(Suppl1):S1\u2013S9","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"4","key":"4336_CR113","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.3892\/ol.2019.10024","volume":"17","author":"M Dai","year":"2019","unstructured":"Dai M, Li L, Qin X (2019) Clinical value of miRNA-122 in the diagnosis and prognosis of various types of cancer. Oncol Lett 17(4):3919\u20133929. https:\/\/doi.org\/10.3892\/ol.2019.10024","journal-title":"Oncol Lett"},{"issue":"9","key":"4336_CR114","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41575-021-00449-x","volume":"18","author":"E Tshibangu-Kabamba","year":"2021","unstructured":"Tshibangu-Kabamba E, Yamaoka Y (2021) Helicobacter pylori infection and antibiotic resistance\u2014from biology to clinical implications. Nat Rev Gastroenterol Hepatol 18(9):613\u2013629. https:\/\/doi.org\/10.1038\/s41575-021-00449-x","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04336-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-025-04336-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04336-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T03:51:06Z","timestamp":1752810666000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-025-04336-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":114,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4336"],"URL":"https:\/\/doi.org\/10.1007\/s00284-025-04336-5","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"11 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"366"}}