{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:46:15Z","timestamp":1780958775682,"version":"3.54.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["No.3\/1\/2\/273\/2021-Nut."],"award-info":[{"award-number":["No.3\/1\/2\/273\/2021-Nut."]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00284-025-04411-x","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T15:43:09Z","timestamp":1754322189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lactiplantibacillus plantarum MTCC 25433 and Quercetin Blend Ameliorate Benzo[a]pyrene-Induced Gut Dysregulation in a Murine Model"],"prefix":"10.1007","volume":"82","author":[{"given":"Shivani Popli","family":"Goyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri A.","family":"Chandratre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanthi Kiran","family":"Kondepudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prarabdh C.","family":"Badgujar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-3763","authenticated-orcid":false,"given":"Chakkaravarthi","family":"Saravanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"4411_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.chemosphere.2018.03.100","volume":"202","author":"L Singh","year":"2018","unstructured":"Singh L, Agarwal T (2018) PAHs in Indian diet: assessing the cancer risk. Chemosphere 202:366\u2013376. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.03.100","journal-title":"Chemosphere"},{"key":"4411_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/10406638.2017.1349679","volume":"40","author":"S Chawda","year":"2020","unstructured":"Chawda S, Tarafdar A, Sinha A, Mishra BK (2020) Profiling and health risk assessment of PAHs content in Tandoori and Tawa Bread from India. Polycycl Aromat Compd 40:21\u201332. https:\/\/doi.org\/10.1080\/10406638.2017.1349679","journal-title":"Polycycl Aromat Compd"},{"key":"4411_CR3","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1016\/j.chemosphere.2015.11.019","volume":"144","author":"X Duan","year":"2016","unstructured":"Duan X, Shen G, Yang H et al (2016) Dietary intake polycyclic aromatic hydrocarbons (PAHs) and associated cancer risk in a cohort of Chinese urban adults: Inter- and intra-individual variability. Chemosphere 144:2469\u20132475. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.11.019","journal-title":"Chemosphere"},{"key":"4411_CR4","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1093\/CARCIN\/23.11.1839","volume":"23","author":"C Sachse","year":"2002","unstructured":"Sachse C, Smith G, Wilkie MJV et al (2002) A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis 23:1839\u20131850. https:\/\/doi.org\/10.1093\/CARCIN\/23.11.1839","journal-title":"Carcinogenesis"},{"key":"4411_CR5","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/J.1742-4658.2006.05159.X","volume":"273","author":"P Irigaray","year":"2006","unstructured":"Irigaray P, Ogier V, Jacquenet S et al (2006) Benzo[a]pyrene impairs beta-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant. FEBS J 273:1362\u20131372. https:\/\/doi.org\/10.1111\/J.1742-4658.2006.05159.X","journal-title":"FEBS J"},{"key":"4411_CR6","doi-asserted-by":"publisher","first-page":"28947","DOI":"10.18632\/ONCOTARGET.7901","volume":"7","author":"KL Harris","year":"2016","unstructured":"Harris KL, Pulliam SR, Okoro E et al (2016) Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget 7:28947\u201328960. https:\/\/doi.org\/10.18632\/ONCOTARGET.7901","journal-title":"Oncotarget"},{"key":"4411_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.112775","volume":"209","author":"MA Mallah","year":"2022","unstructured":"Mallah MA, Changxing L, Mallah MA et al (2022) Association of urinary polycyclic aromatic hydrocarbon metabolites and cardiovascular disease among US population: a cross-sectional study. Environ Res 209:112775. https:\/\/doi.org\/10.1016\/j.envres.2022.112775","journal-title":"Environ Res"},{"key":"4411_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/J.CRTOX.2024.100162","volume":"6","author":"KL Harris","year":"2024","unstructured":"Harris KL, Harris KJ, Banks LD et al (2024) Acceleration of benzo(a)pyrene-induced colon carcinogenesis by Western diet in a rat model of colon cancer. Curr Res Toxicol 6:100162. https:\/\/doi.org\/10.1016\/J.CRTOX.2024.100162","journal-title":"Curr Res Toxicol"},{"key":"4411_CR9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.fct.2016.06.019","volume":"95","author":"BO Ajayi","year":"2016","unstructured":"Ajayi BO, Adedara IA, Farombi EO (2016) Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt\/beta-catenin signaling in colons of BALB\/c mice. Food Chem Toxicol 95:42\u201351. https:\/\/doi.org\/10.1016\/j.fct.2016.06.019","journal-title":"Food Chem Toxicol"},{"key":"4411_CR10","doi-asserted-by":"publisher","first-page":"31027","DOI":"10.1038\/srep31027","volume":"6","author":"C Ribi\u00e8re","year":"2016","unstructured":"Ribi\u00e8re C, Peyret P, Parisot N et al (2016) Oral exposure to environmental pollutant benzo[a]pyrene impacts the intestinal epithelium and induces gut microbial shifts in murine model. Sci Rep 6:31027. https:\/\/doi.org\/10.1038\/srep31027","journal-title":"Sci Rep"},{"key":"4411_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.01562","volume":"8","author":"C Defois","year":"2017","unstructured":"Defois C, Ratel J, Denis S et al (2017) Environmental pollutant Benzo[a]Pyrene impacts the volatile metabolome and transcriptome of the human gut microbiota. Front Microbiol 8:1\u201312. https:\/\/doi.org\/10.3389\/fmicb.2017.01562","journal-title":"Front Microbiol"},{"key":"4411_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/J.FOODRES.2019.108599","author":"S He","year":"2019","unstructured":"He S, Li X, Li C et al (2019) Isoorientin attenuates benzo[a]pyrene-induced colonic injury and gut microbiota disorders in mice. Food Res Int. https:\/\/doi.org\/10.1016\/J.FOODRES.2019.108599","journal-title":"Food Res Int"},{"key":"4411_CR13","doi-asserted-by":"publisher","DOI":"10.3346\/JKMS.2022.37.E235","author":"Z Zheng","year":"2022","unstructured":"Zheng Z, Park JK, Kwon OW et al (2022) The risk of gastrointestinal cancer on daily intake of low-dose BaP in C57BL\/6 for 60 days. J Korean Med Sci. https:\/\/doi.org\/10.3346\/JKMS.2022.37.E235","journal-title":"J Korean Med Sci"},{"key":"4411_CR14","doi-asserted-by":"publisher","first-page":"140891","DOI":"10.1016\/J.CHEMOSPHERE.2023.140891","volume":"349","author":"SP Goyal","year":"2024","unstructured":"Goyal SP, Maurya R, Mishra V et al (2024) Ameliorative potential of synbiotic combination of Lactobacillus sp. and polyphenols against Benzo[a]pyrene-induced toxicity in Caco-2 cell line. Chemosphere 349:140891. https:\/\/doi.org\/10.1016\/J.CHEMOSPHERE.2023.140891","journal-title":"Chemosphere"},{"key":"4411_CR15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/S10637-018-0622-9","volume":"37","author":"AC Huderson","year":"2019","unstructured":"Huderson AC, Rekha Devi PV, Niaz MS et al (2019) Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin\/+ mouse model of colon carcinogenesis. Invest New Drugs 37:238. https:\/\/doi.org\/10.1007\/S10637-018-0622-9","journal-title":"Invest New Drugs"},{"key":"4411_CR16","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.3390\/ijms20225533","volume":"20","author":"KS Kim","year":"2019","unstructured":"Kim KS, Kim NY, Son JY et al (2019) Curcumin ameliorates Benzo[a]pyrene-induced DNA damages in stomach tissues of sprague-dawley rats. Int J Mol Sci 20:5533. https:\/\/doi.org\/10.3390\/ijms20225533","journal-title":"Int J Mol Sci"},{"key":"4411_CR17","doi-asserted-by":"publisher","first-page":"326S","DOI":"10.1093\/AJCN\/81.1.326S","volume":"81","author":"LI Mennen","year":"2005","unstructured":"Mennen LI, Walker R, Bennetau-Pelissero C, Scalbert A (2005) Risks and safety of polyphenol consumption. Am J Clin Nutr 81:326S-329S. https:\/\/doi.org\/10.1093\/AJCN\/81.1.326S","journal-title":"Am J Clin Nutr"},{"key":"4411_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.736129","author":"L Yu","year":"2021","unstructured":"Yu L, Zhang L, Duan H et al (2021) The protection of Lactiplantibacillus plantarum CCFM8661 against benzopyrene-induced toxicity via regulation of the gut microbiota. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.736129","journal-title":"Front Immunol"},{"key":"4411_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202001149","author":"J Liu","year":"2021","unstructured":"Liu J, He H, Xu M et al (2021) Detoxification of oral exposure to Benzo(a)pyrene by Lactobacillus plantarum CICC 23121 in Mice. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.202001149","journal-title":"Mol Nutr Food Res"},{"key":"4411_CR20","doi-asserted-by":"publisher","first-page":"4906","DOI":"10.3390\/ijms22094906","volume":"22","author":"I Benito","year":"2021","unstructured":"Benito I, Enc\u00edo IJ, Milagro FI et al (2021) Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in combination with quercetin inhibit colorectal cancer development in ApcMin\/+ Mice. Int J Mol Sci 22:4906. https:\/\/doi.org\/10.3390\/ijms22094906","journal-title":"Int J Mol Sci"},{"key":"4411_CR21","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.3390\/antiox10122001","volume":"10","author":"M Ju\u00e1rez-Fern\u00e1ndez","year":"2021","unstructured":"Ju\u00e1rez-Fern\u00e1ndez M, Porras D, Petrov P et al (2021) The synbiotic combination of Akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants 10:2001. https:\/\/doi.org\/10.3390\/antiox10122001","journal-title":"Antioxidants"},{"key":"4411_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/J.METOP.2021.100093","volume":"10","author":"A Pegah","year":"2021","unstructured":"Pegah A, Abbasi-Oshaghi E, Khodadadi I et al (2021) Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats. Metabol Open 10:100093. https:\/\/doi.org\/10.1016\/J.METOP.2021.100093","journal-title":"Metabol Open"},{"key":"4411_CR23","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9863845","author":"Y Fei","year":"2022","unstructured":"Fei Y, Zhang S, Han S et al (2022) The role of dihydroresveratrol in enhancing the synergistic effect of Ligilactobacillus salivarius Li01 and resveratrol in ameliorating colitis in mice. Research. https:\/\/doi.org\/10.34133\/2022\/9863845","journal-title":"Research"},{"key":"4411_CR24","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1002\/FSN3.3839","volume":"12","author":"F Mohammadi","year":"2023","unstructured":"Mohammadi F, Mohsenpour MA, Sohrabi Z et al (2023) The effects of powdered drinks enriched with curcumin and probiotics on lipid profile and atherogenic indices in patients with metabolic syndrome: a randomized, double-blinded, placebo-controlled clinical trial. Food Sci Nutr 12:1257. https:\/\/doi.org\/10.1002\/FSN3.3839","journal-title":"Food Sci Nutr"},{"key":"4411_CR25","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3390\/MICROORGANISMS12071443","volume":"12","author":"ML Giancola","year":"2024","unstructured":"Giancola ML, Fontana A, Panebianco C et al (2024) Efficacy of a multistrain synbiotic treatment in acute and post-acute COVID-19 patients: a double-blind. Placebo-Controlled Randomized Trial Microorganisms 12:1443. https:\/\/doi.org\/10.3390\/MICROORGANISMS12071443","journal-title":"Placebo-Controlled Randomized Trial Microorganisms"},{"key":"4411_CR26","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3390\/FOODS14060986\/S1","volume":"14","author":"JMA Brasil","year":"2025","unstructured":"Brasil JMA, Melo NC, de Osampaio KB et al (2025) Impact of a Limosilactobacillus fermentum, quercetin, and resveratrol nutraceutical on fecal microbiota composition and metabolic activity in healthy and hypertensive subjects. Foods 14:986. https:\/\/doi.org\/10.3390\/FOODS14060986\/S1","journal-title":"Foods"},{"key":"4411_CR27","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114525000923","author":"MA Mohsenpour","year":"2025","unstructured":"Mohsenpour MA, Mohammadi F, Sohrabi Z et al (2025) Mental health and health-related quality of life response to curcumin-probiotic drink powder co-supplementation in adults with overweight\/obesity and metabolic syndrome: a four-arm randomised, double-blind, placebo-controlled, clinical trial. British J Nutr. https:\/\/doi.org\/10.1017\/S0007114525000923","journal-title":"British J Nutr"},{"key":"4411_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.CBI.2019.04.026","volume":"307","author":"BO Ajayi","year":"2019","unstructured":"Ajayi BO, Adedara IA, Farombi EO (2019) 6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB\/c mice. Chem Biol Interact 307:1\u20137. https:\/\/doi.org\/10.1016\/J.CBI.2019.04.026","journal-title":"Chem Biol Interact"},{"key":"4411_CR29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3390\/antiox10050787","volume":"10","author":"M Kim","year":"2021","unstructured":"Kim M, Jee S-C, Kim K-S et al (2021) Quercetin and isorhamnetin attenuate Benzo[a]pyrene-induced toxicity by modulating detoxification enzymes through the AhR and NRF2 signaling pathways. Antioxidants 10:787. https:\/\/doi.org\/10.3390\/antiox10050787","journal-title":"Antioxidants"},{"key":"4411_CR30","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1248\/BPB.30.2268","volume":"30","author":"S Kamaraj","year":"2007","unstructured":"Kamaraj S, Vinodhkumar R, Anandakumar P et al (2007) The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol Pharm Bull 30:2268\u20132273. https:\/\/doi.org\/10.1248\/BPB.30.2268","journal-title":"Biol Pharm Bull"},{"key":"4411_CR31","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1093\/JN\/138.9.1615","volume":"138","author":"S Egert","year":"2008","unstructured":"Egert S, Wolffram S, Bosy-Westphal A et al (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138:1615\u20131621. https:\/\/doi.org\/10.1093\/JN\/138.9.1615","journal-title":"J Nutr"},{"key":"4411_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/AJI.13644","author":"S Vaez","year":"2023","unstructured":"Vaez S, Parivr K, Amidi F et al (2023) Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: a randomized clinical trial. Am J Reprod Immunol. https:\/\/doi.org\/10.1111\/AJI.13644","journal-title":"Am J Reprod Immunol"},{"key":"4411_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/J.EBIOM.2023.104481","volume":"90","author":"A Nambiar","year":"2023","unstructured":"Nambiar A, Kellogg D, Justice J et al (2023) Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine 90:104481. https:\/\/doi.org\/10.1016\/J.EBIOM.2023.104481","journal-title":"EBioMedicine"},{"key":"4411_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2024.07.013","author":"NC Li","year":"2024","unstructured":"Li NC, Cui C, Xu J et al (2024) Quercetin intervention reduced hepatic fat deposition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled crossover clinical trial. Am J Clin Nutr. https:\/\/doi.org\/10.1016\/j.ajcnut.2024.07.013","journal-title":"Am J Clin Nutr"},{"key":"4411_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-75702-5","volume":"10","author":"S Singh","year":"2020","unstructured":"Singh S, Bhatia R, Khare P et al (2020) Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep 10:1\u201314. https:\/\/doi.org\/10.1038\/s41598-020-75702-5","journal-title":"Sci Rep"},{"key":"4411_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/FNUT.2022.839364\/BIBTEX","volume":"9","author":"C Wang","year":"2022","unstructured":"Wang C, Zhao F, Bai Y et al (2022) Proteomic analysis of the protective effect of eriodictyol on Benzo(a)pyrene-induced caco-2 cytotoxicity. Front Nutr 9:319. https:\/\/doi.org\/10.3389\/FNUT.2022.839364\/BIBTEX","journal-title":"Front Nutr"},{"key":"4411_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/J.FCT.2019.05.029","volume":"130","author":"HJ Koo","year":"2019","unstructured":"Koo HJ, Lee KR, Kim HS, Lee BM (2019) Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Food Chem Toxicol 130:99\u2013108. https:\/\/doi.org\/10.1016\/J.FCT.2019.05.029","journal-title":"Food Chem Toxicol"},{"key":"4411_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.fct.2013.05.040","volume":"59","author":"H Zhao","year":"2013","unstructured":"Zhao H, Zhou F, Qi Y et al (2013) Screening of Lactobacillus strains for their ability to bind Benzo(a)pyrene and the mechanism of the process. Food Chem Toxicol 59:67\u201371. https:\/\/doi.org\/10.1016\/j.fct.2013.05.040","journal-title":"Food Chem Toxicol"},{"key":"4411_CR39","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jchromb.2019.03.024","volume":"1114\u20131115","author":"S Shoukat","year":"2019","unstructured":"Shoukat S, Liu Y, Rehman A, Zhang B (2019) Screening of Bifidobacterium strains with assignment of functional groups to bind with benzo[a]pyrene under food stress factors. J Chromatogr B 1114\u20131115:100\u2013109. https:\/\/doi.org\/10.1016\/j.jchromb.2019.03.024","journal-title":"J Chromatogr B"},{"key":"4411_CR40","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S1383-5718(97)00092-2","volume":"393","author":"HY Chen","year":"1997","unstructured":"Chen HY, Yen GC (1997) Possible mechanisms of antimutagens by various teas as judged by their effects on mutagenesis by 2-amino-3-methylimidazo[4,5-f]quinoline and benzo[a]pyrene. Mutat Res 393:115\u2013122. https:\/\/doi.org\/10.1016\/S1383-5718(97)00092-2","journal-title":"Mutat Res"},{"key":"4411_CR41","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/JN.108.100867","volume":"139","author":"T Suzuki","year":"2009","unstructured":"Suzuki T, Hara H (2009) Quercetin enhances intestinal barrier function through the assembly of zonnula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in caco-2 cells. J Nutr 139:965\u2013974. https:\/\/doi.org\/10.3945\/JN.108.100867","journal-title":"J Nutr"},{"key":"4411_CR42","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/1471-2180-10-316","volume":"10","author":"RC Anderson","year":"2010","unstructured":"Anderson RC, Cookson AL, McNabb WC et al (2010) Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiol 10:316. https:\/\/doi.org\/10.1186\/1471-2180-10-316","journal-title":"BMC Microbiol"},{"key":"4411_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-022-01627-9","author":"W Lou","year":"2022","unstructured":"Lou W, di Zhang M, Chen Q et al (2022) Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor. Lipids Health Dis. https:\/\/doi.org\/10.1186\/S12944-022-01627-9","journal-title":"Lipids Health Dis"},{"key":"4411_CR44","doi-asserted-by":"publisher","first-page":"12629","DOI":"10.1021\/ACS.JAFC.2C04526\/ASSET\/IMAGES\/MEDIUM\/JF2C04526_0009.GIF","volume":"70","author":"Z Wang","year":"2022","unstructured":"Wang Z, Shi L, Li H et al (2022) Selenium-enriched black soybean protein prevents Benzo(a)pyrene-induced pyroptotic colon damage and gut dysbacteriosis. J Agric Food Chem 70:12629\u201312640. https:\/\/doi.org\/10.1021\/ACS.JAFC.2C04526\/ASSET\/IMAGES\/MEDIUM\/JF2C04526_0009.GIF","journal-title":"J Agric Food Chem"},{"key":"4411_CR45","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/JLB.3RU0220-111","volume":"109","author":"H Ma","year":"2021","unstructured":"Ma H, Qiu Y, Yang H (2021) Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity. J Leukoc Biol 109:339. https:\/\/doi.org\/10.1002\/JLB.3RU0220-111","journal-title":"J Leukoc Biol"},{"key":"4411_CR46","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1084\/JEM.20011793","volume":"195","author":"P Poussier","year":"2002","unstructured":"Poussier P, Ning T, Banerjee D, Julius M (2002) A unique subset of self-specific intraintestinal T cells maintains gut integrity. J Exp Med 195:1491. https:\/\/doi.org\/10.1084\/JEM.20011793","journal-title":"J Exp Med"},{"key":"4411_CR47","doi-asserted-by":"publisher","first-page":"292","DOI":"10.4161\/GMIC.24706","volume":"4","author":"SM Alaish","year":"2013","unstructured":"Alaish SM, Smith AD, Timmons J et al (2013) Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. Gut Microbes 4:292. https:\/\/doi.org\/10.4161\/GMIC.24706","journal-title":"Gut Microbes"},{"key":"4411_CR48","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/SJI.12159","volume":"79","author":"SG Kiige","year":"2014","unstructured":"Kiige SG, Mutiso JM, Laban LT et al (2014) F1 cross-breed between susceptible BALB\/c and resistant swiss mice infected with leishmania major exhibit an intermediate phenotype for lesion sizes and type 1 cytokines but show low level of total IgG antibodies. Scand J Immunol 79:283\u2013291. https:\/\/doi.org\/10.1111\/SJI.12159","journal-title":"Scand J Immunol"},{"key":"4411_CR49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000509716","volume":"13","author":"T Bleul","year":"2021","unstructured":"Bleul T, Zhuang X, Hildebrand A et al (2021) Different innate immune responses in BALB\/c and C57BL\/6 strains following corneal transplantation. J Innate Immun 13:49\u201359. https:\/\/doi.org\/10.1159\/000509716","journal-title":"J Innate Immun"},{"key":"4411_CR50","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/modpathol.3800301","volume":"18","author":"MB Resnick","year":"2005","unstructured":"Resnick MB, Konkin T, Routhier J et al (2005) (2004) Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Modern Pathol 18:511\u2013518. https:\/\/doi.org\/10.1038\/modpathol.3800301","journal-title":"Modern Pathol"},{"key":"4411_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2018.01942\/BIBTEX","volume":"10","author":"AA Bhat","year":"2019","unstructured":"Bhat AA, Uppada S, Achkar IW et al (2019) Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk. Front Physiol 10:383629. https:\/\/doi.org\/10.3389\/FPHYS.2018.01942\/BIBTEX","journal-title":"Front Physiol"},{"key":"4411_CR52","doi-asserted-by":"publisher","first-page":"188579","DOI":"10.1016\/J.BBCAN.2021.188579","volume":"1876","author":"R Gundamaraju","year":"2021","unstructured":"Gundamaraju R, Chong WC (2021) Consequence of distinctive expression of MUC2 in colorectal cancers: how much is actually bad? Biochimica et Biophysica Acta (BBA) 1876:188579. https:\/\/doi.org\/10.1016\/J.BBCAN.2021.188579","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"4411_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/CELLS10020367","volume":"10","author":"M Zerfaoui","year":"2021","unstructured":"Zerfaoui M, Dokunmu TM, Toraih EA et al (2021) New insights into the link between melanoma and thyroid cancer: role of nucleocytoplasmic trafficking. Cells 10:1\u201313. https:\/\/doi.org\/10.3390\/CELLS10020367","journal-title":"Cells"},{"key":"4411_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS11091502\/S1","author":"HA Bakshi","year":"2022","unstructured":"Bakshi HA, Quinn GA, Nasef MM et al (2022) Crocin inhibits angiogenesis and metastasis in colon cancer via TNF-\u03b1\/NF-kB\/VEGF pathways. Cells. https:\/\/doi.org\/10.3390\/CELLS11091502\/S1","journal-title":"Cells"},{"key":"4411_CR55","doi-asserted-by":"publisher","first-page":"306","DOI":"10.18502\/IJPH.V52I2.11883","volume":"52","author":"X Zeng","year":"2023","unstructured":"Zeng X, Yang X, Parhatsayim S et al (2023) Forkhead box A2 promotes colorectal cancer progression and targets BCL2-associated X (BAX) protein. Iran J Public Health 52:306. https:\/\/doi.org\/10.18502\/IJPH.V52I2.11883","journal-title":"Iran J Public Health"},{"key":"4411_CR56","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/J.JNUTBIO.2012.03.005","volume":"23","author":"EE Vomhof-DeKrey","year":"2012","unstructured":"Vomhof-DeKrey EE, Picklo MJ (2012) The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. J Nutr Biochem 23:1201\u20131206. https:\/\/doi.org\/10.1016\/J.JNUTBIO.2012.03.005","journal-title":"J Nutr Biochem"},{"key":"4411_CR57","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1467-789X.2010.00797.x","volume":"12","author":"M Diamant","year":"2011","unstructured":"Diamant M, Blaak EE, de Vos WM (2011) Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obes Rev 12:272\u2013281. https:\/\/doi.org\/10.1111\/j.1467-789X.2010.00797.x","journal-title":"Obes Rev"},{"key":"4411_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/FCIMB.2021.606490\/FULL","volume":"11","author":"YK Zhang","year":"2021","unstructured":"Zhang YK, Zhang Q, Wang YL et al (2021) A comparison study of age and colorectal cancer-related gut bacteria. Front Cell Infect Microbiol 11:1. https:\/\/doi.org\/10.3389\/FCIMB.2021.606490\/FULL","journal-title":"Front Cell Infect Microbiol"},{"key":"4411_CR59","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/J.FREERADBIOMED.2016.11.037","volume":"102","author":"D Porras","year":"2017","unstructured":"Porras D, Nistal E, Mart\u00ednez-Fl\u00f3rez S et al (2017) Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radic Biol Med 102:188\u2013202. https:\/\/doi.org\/10.1016\/J.FREERADBIOMED.2016.11.037","journal-title":"Free Radic Biol Med"},{"key":"4411_CR60","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3748\/WJG.V27.I1.107","volume":"27","author":"ES Rahayu","year":"2021","unstructured":"Rahayu ES, Mariyatun M, Manurung NEP et al (2021) Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults. World J Gastroenterol 27:107\u2013128. https:\/\/doi.org\/10.3748\/WJG.V27.I1.107","journal-title":"World J Gastroenterol"},{"key":"4411_CR61","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.1002\/JSFA.12538","volume":"103","author":"H Chen","year":"2023","unstructured":"Chen H, Zhao H, Qi X et al (2023) Lactobacillus plantarum HF02 alleviates lipid accumulation and intestinal microbiota dysbiosis in high-fat diet-induced obese mice. J Sci Food Agric 103:4625\u20134637. https:\/\/doi.org\/10.1002\/JSFA.12538","journal-title":"J Sci Food Agric"},{"key":"4411_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2024.1362464","author":"B Li","year":"2024","unstructured":"Li B, Yan Y, Zhang T et al (2024) Quercetin reshapes gut microbiota homeostasis and modulates brain metabolic profile to regulate depression-like behaviors induced by CUMS in rats. Front Pharmacol. https:\/\/doi.org\/10.3389\/FPHAR.2024.1362464","journal-title":"Front Pharmacol"},{"key":"4411_CR63","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.chom.2023.01.013","volume":"31","author":"X Zhang","year":"2023","unstructured":"Zhang X, Yu D, Wu D et al (2023) Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance. Cell Host Microbe 31:418-432.e8. https:\/\/doi.org\/10.1016\/j.chom.2023.01.013","journal-title":"Cell Host Microbe"},{"key":"4411_CR64","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1021\/PR4009783","volume":"13","author":"JL Nugent","year":"2014","unstructured":"Nugent JL, McCoy AN, Addamo CJ et al (2014) Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas. J Proteome Res 13:1921. https:\/\/doi.org\/10.1021\/PR4009783","journal-title":"J Proteome Res"},{"key":"4411_CR65","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.3748\/WJG.V21.I29.8787","volume":"21","author":"SM Jandhyala","year":"2015","unstructured":"Jandhyala SM, Talukdar R, Subramanyam C et al (2015) Role of the normal gut microbiota. World J Gastroenterol: WJG 21:8787. https:\/\/doi.org\/10.3748\/WJG.V21.I29.8787","journal-title":"World J Gastroenterol: WJG"},{"key":"4411_CR66","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/S12967-023-04119-1","volume":"21","author":"J Liu","year":"2023","unstructured":"Liu J, Huang X, Chen C et al (2023) Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction. J Transl Med 21:373. https:\/\/doi.org\/10.1186\/S12967-023-04119-1","journal-title":"J Transl Med"},{"key":"4411_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.155084","volume":"832","author":"S Popli","year":"2022","unstructured":"Popli S, Badgujar PC, Agarwal T et al (2022) Persistent organic pollutants in foods, their interplay with gut microbiota and resultant toxicity. Sci Total Environ 832:155084. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.155084","journal-title":"Sci Total Environ"},{"key":"4411_CR68","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2021.697408\/BIBTEX","volume":"11","author":"S Rodr\u00edguez-Enr\u00edquez","year":"2021","unstructured":"Rodr\u00edguez-Enr\u00edquez S, Robledo-Cadena DX, Gallardo-P\u00e9rez JC et al (2021) Acetate promotes a differential energy metabolic response in human HCT 116 and COLO 205 colon cancer cells impacting cancer cell growth and invasiveness. Front Oncol 11:697408. https:\/\/doi.org\/10.3389\/FONC.2021.697408\/BIBTEX","journal-title":"Front Oncol"},{"key":"4411_CR69","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.3390\/ANTIOX10081251\/S1","volume":"10","author":"Y Tan","year":"2021","unstructured":"Tan Y, Tam CC, Rolston M et al (2021) Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high-fat diets. Antioxidants 10:1251. https:\/\/doi.org\/10.3390\/ANTIOX10081251\/S1","journal-title":"Antioxidants"},{"key":"4411_CR70","doi-asserted-by":"publisher","first-page":"14732","DOI":"10.1021\/ACS.JAFC.2C06212\/ASSET\/IMAGES\/LARGE\/JF2C06212_0008.JPEG","volume":"70","author":"Z Shi","year":"2022","unstructured":"Shi Z, Zhang C, Lei H et al (2022) Structural insights into amelioration effects of quercetin and its glycoside derivatives on NAFLD in mice by modulating the gut microbiota and host metabolism. J Agric Food Chem 70:14732\u201314743. https:\/\/doi.org\/10.1021\/ACS.JAFC.2C06212\/ASSET\/IMAGES\/LARGE\/JF2C06212_0008.JPEG","journal-title":"J Agric Food Chem"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04411-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-025-04411-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-025-04411-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T04:44:51Z","timestamp":1756442691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-025-04411-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4411"],"URL":"https:\/\/doi.org\/10.1007\/s00284-025-04411-x","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"15 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments received approval from the Ethical Committee of the National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, (Approval number I\/N\/IAEC\/2023-24\/01\/01) and adhered strictly to the guidelines outlined by the ARRIVE and Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), as mandated by the Government of India.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"434"}}