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However, their effects on marine microbial communities remain poorly understood. Recent theoretical models suggest that high energy inputs can disrupt microbial networks that have evolved under energy-limited conditions. The aim of our study was to determine the community-level effects of two alcohols (ethanol and methanol) and two organic acids (acetate and succinate) using a marine microcosm time-series experiment. We tested three sediment types: one impacted by sewage, one by aquaculture, and one unimpacted. The tested concentrations were 0.05% and 0.5%. At 0.5%, we identified 469 sequence variants (determined from 16\u00a0S rRNA gene sequencing) with more than a twofold increase during the experiment, grouped into two enrichment cascades. At 0.05%, 576 sequence variants responded, forming three cascades. Late-appearing sequence variants showed greater inferred functional diversity than early responders. The stronger effects observed at lower concentrations support the theory that energy conservation drives microbial diversification, indicating that even low-level pollution can cause significant ecological changes. These findings highlight the importance of considering microbial community responses in environmental impact assessments of organic pollution in marine ecosystems.<\/jats:p>","DOI":"10.1007\/s00284-025-04581-8","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:49:58Z","timestamp":1763016598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cascade Responses of Microbial Communities To Alcohols and Organic Acids in a Marine Microcosm Experiment"],"prefix":"10.1007","volume":"83","author":[{"given":"Ewelina Blanka","family":"Grad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Rudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga Leena","family":"Angell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny Helene Mary","family":"Storvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"7","key":"4581_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/0043-1354(78)90149-5","volume":"12","author":"N Narkis","year":"1978","unstructured":"Narkis N, Henfeld-Furie S (1978) Direct analytical procedure for determination of volatile organic acids in raw municipal wastewater. 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