{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:36:35Z","timestamp":1776749795480,"version":"3.51.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Jilin Province's Training Program of Innovation and Entrepreneurship for Undergraduates","award":["no.202410201105"],"award-info":[{"award-number":["no.202410201105"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00284-026-04778-5","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:43:05Z","timestamp":1771407785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of a KL239-OCL6-ST63 Carbapenem-Resistant Acinetobacter pittii Strain, Co-carrying blaNDM-1 and blaOXA-500"],"prefix":"10.1007","volume":"83","author":[{"given":"Di","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinlong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"issue":"1","key":"4778_CR1","doi-asserted-by":"publisher","DOI":"10.1128\/mra.01038-23","volume":"13","author":"E Bello-L\u00f3pez","year":"2024","unstructured":"Bello-L\u00f3pez E et al (2024) Genome sequence of an Acinetobacter pittii strain obtained from a red-lored parrot with pneumonia. Microbiol Resour Announc 13(1):e0103823","journal-title":"Microbiol Resour Announc"},{"key":"4778_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2025.105845","volume":"135","author":"MS Rana","year":"2025","unstructured":"Rana MS, Lee JC, Kim S (2025) Chromosomal co-carriage of bla(OXA-23) and bla(OXA-500) in a carbapenem-resistant Acinetobacter pittii isolate. Infect Genet Evol 135:105845","journal-title":"Infect Genet Evol"},{"key":"4778_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.meegid.2016.05.011","volume":"43","author":"B Bedeni\u0107","year":"2016","unstructured":"Bedeni\u0107 B et al (2016) Molecular characterization of class b carbapenemases in advanced stage of dissemination and emergence of class d carbapenemases in Enterobacteriaceae from Croatia. Infect Genet Evol 43:74\u201382","journal-title":"Infect Genet Evol"},{"key":"4778_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00559","volume":"10","author":"R D'Souza","year":"2019","unstructured":"D\u2019Souza R et al (2019) Phenotypic and genotypic characterization of Acinetobacter spp. panel strains: a cornerstone to facilitate antimicrobial development. Front Microbiol 10:559","journal-title":"Front Microbiol"},{"key":"4778_CR5","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.2147\/IDR.S426182","volume":"16","author":"C Tian","year":"2023","unstructured":"Tian C et al (2023) Emergence of a ST248(Pasteur)-ST1068(Oxford) carbapenem resistance Acinetobacter pittii clinical isolate in China, co-harboring OXA-58 and OXA-500 carbapenemases. Infect Drug Resist 16:5681\u20135684","journal-title":"Infect Drug Resist"},{"key":"4778_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14101037","author":"W Liu","year":"2025","unstructured":"Liu W et al (2025) Genomic characterization of a carbapenem-resistant Acinetobacter pittii strain harboring chromosome-borne bla(NDM-1) from China. Pathogens. https:\/\/doi.org\/10.3390\/pathogens14101037","journal-title":"Pathogens"},{"issue":"6","key":"4778_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2025.107594","volume":"66","author":"S Liu","year":"2025","unstructured":"Liu S et al (2025) Emergence of a novel transferable megaplasmid driving bla(VIM-24) and tmexCD3-toprJ3 dissemination in clinical Pseudomonas fulva isolates. Int J Antimicrob Agents 66(6):107594","journal-title":"Int J Antimicrob Agents"},{"key":"4778_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105979","volume":"121","author":"H Ye","year":"2025","unstructured":"Ye H et al (2025) Unravelling tandem repeat-mediated mutagenesis drive rapid diversification of KPC enzymes: emergence of bla(KPC-263) and enhanced resistance to ceftazidime-avibactam. EBioMedicine 121:105979","journal-title":"EBioMedicine"},{"issue":"5","key":"4778_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112369","volume":"28","author":"Y Liu","year":"2025","unstructured":"Liu Y et al (2025) First characterization of four repeat regions with the bla (NDM-1) carried on an IncFII plasmid in Enterobacter hormaechei. iScience 28(5):112369","journal-title":"iScience"},{"key":"4778_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1666215","volume":"16","author":"D Zhang","year":"2025","unstructured":"Zhang D et al (2025) Emergence of NDM-1 on IncR-IncFIA (HI1) plasmid in carbapenem-resistant Kluyvera ascorbata from China. Front Microbiol 16:1666215","journal-title":"Front Microbiol"},{"issue":"1","key":"4778_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-025-11493-1","volume":"26","author":"Y Yang","year":"2025","unstructured":"Yang Y et al (2025) Genomic insights and epidemiology of mcr-1-carrying Escherichia albertii isolated from agricultural soil in China. BMC Genomics 26(1):344","journal-title":"BMC Genomics"},{"issue":"9","key":"4778_CR12","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00496-24","volume":"12","author":"X Liu","year":"2024","unstructured":"Liu X et al (2024) Emergence of plasmid-borne tet(X4) resistance gene in clinical isolate of eravacycline- and omadacycline-resistant Klebsiella pneumoniae ST485. Microbiol Spectr 12(9):e0049624","journal-title":"Microbiol Spectr"},{"issue":"1","key":"4778_CR13","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2317915","volume":"13","author":"Q Luo","year":"2024","unstructured":"Luo Q et al (2024) ESKAPE in China: epidemiology and characteristics of antibiotic resistance. Emerg Microbes Infect 13(1):2317915","journal-title":"Emerg Microbes Infect"},{"issue":"8","key":"4778_CR14","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/j.1600-0463.2007.apm_630.x","volume":"115","author":"S Stepanovi\u0107","year":"2007","unstructured":"Stepanovi\u0107 S et al (2007) Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci. APMIS 115(8):891\u2013899","journal-title":"APMIS"},{"issue":"10","key":"4778_CR15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/AAC.00649-18","volume":"62","author":"B Chavda","year":"2018","unstructured":"Chavda B, Lv J, Hou M, Chavda KD, Kreiswirth BN, FengY, Chen L, Yu F. Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacaeIsolate from China. Antimicrobial Agents and Chemotherapy. 2018; 62(10): e00649-18. https:\/\/doi.org\/10.1128\/AAC.00649-18.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"4778_CR16","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1080\/21505594.2018.1486140","volume":"9","author":"J Mao","year":"2018","unstructured":"Mao J et al (2018) Antibiotic exposure elicits the emergence of colistin- and carbapenem-resistant Escherichia coli coharboring MCR-1 and NDM-5 in a patient. Virulence 9(1):1001\u20131007","journal-title":"Virulence"},{"issue":"1","key":"4778_CR17","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2026.2614739","volume":"15","author":"L Zeng","year":"2026","unstructured":"Zeng L, Feng Y, Wang M (2026) Can we escape from top-priority ESKAPE pathogens? Emerg Microbes Infect 15(1):2614739","journal-title":"Emerg Microbes Infect"},{"key":"4778_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2026.108307","volume":"212","author":"IV Rocha","year":"2026","unstructured":"Rocha IV et al (2026) Post-pandemic molecular epidemiology of \u03b2-lactam resistance and biofilm formation in multidrug-resistant Acinetobacter baumannii from a Brazilian tertiary hospital. Microb Pathog 212:108307","journal-title":"Microb Pathog"},{"issue":"12","key":"4778_CR19","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00707-25","volume":"69","author":"CS Nodari","year":"2025","unstructured":"Nodari CS et al (2025) ISAba1-mediated bla(ADC) disruption restores third-generation cephalosporin susceptibility in a clinical Acinetobacter baumannii isolate. Antimicrob Agents Chemother 69(12):e0070725","journal-title":"Antimicrob Agents Chemother"},{"key":"4778_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2025.108279","volume":"163","author":"YR Wang","year":"2026","unstructured":"Wang YR et al (2026) Susceptibilities of cefiderocol, meropenem-xeruborbactam, cefepime-taniborbactam, aztreonam-avibactam, and sulbactam-durlobactam against imipenem-non-susceptible Gram-negative bacilli in Taiwan. Int J Infect Dis 163:108279","journal-title":"Int J Infect Dis"},{"key":"4778_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-026-05415-6","author":"G Mellon","year":"2026","unstructured":"Mellon G et al (2026) An unusual cross-transmission of carbapenem-resistant Acinetobacter baumannii: when the endoscope isn\u2019t the only culprit. Eur J Clin Microbiol Infect Dis. https:\/\/doi.org\/10.1007\/s10096-026-05415-6","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"23","key":"4778_CR22","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/j.scib.2023.10.038","volume":"68","author":"L Liu","year":"2023","unstructured":"Liu L et al (2023) Chasing the landscape for intrahospital transmission and evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae. Sci Bull (Beijing) 68(23):3027\u20133047","journal-title":"Sci Bull (Beijing)"},{"issue":"4","key":"4778_CR23","first-page":"1240","volume":"41","author":"X Yan","year":"2025","unstructured":"Yan X et al (2025) Multidrug resistance of Helicobacter pylori and its impact on the diagnosis and treatment of gastrointestinal diseases and countermeasures. Sheng Wu Gong Cheng Xue Bao 41(4):1240\u20131251","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"issue":"12","key":"4778_CR24","doi-asserted-by":"publisher","DOI":"10.1128\/mra.00863-25","volume":"14","author":"MSI Sujan","year":"2025","unstructured":"Sujan MSI et al (2025) Draft genome sequence of Acinetobacter pittii carrying the ISAba43 mobile genetic element isolated from a urinary tract infection sample in Dhaka, Bangladesh. Microbiol Resour Announc 14(12):e0086325","journal-title":"Microbiol Resour Announc"},{"issue":"7","key":"4778_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012376","volume":"20","author":"H Huang","year":"2024","unstructured":"Huang H et al (2024) An inhibitory mechanism of AasS, an exogenous fatty acid scavenger: implications for re-sensitization of FAS II antimicrobials. PLoS Pathog 20(7):e1012376","journal-title":"PLoS Pathog"},{"issue":"1","key":"4778_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011110","volume":"19","author":"Y Shi","year":"2023","unstructured":"Shi Y et al (2023) The opportunistic pathogen Pseudomonas aeruginosa exploits bacterial biotin synthesis pathway to benefit its infectivity. PLoS Pathog 19(1):e1011110","journal-title":"PLoS Pathog"},{"issue":"3","key":"4778_CR27","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02688-21","volume":"10","author":"Q Chen","year":"2022","unstructured":"Chen Q et al (2022) A small KPC-2-producing plasmid in Klebsiella pneumoniae: implications for diversified vehicles of carbapenem resistance. Microbiol Spectr 10(3):e0268821","journal-title":"Microbiol Spectr"},{"key":"4778_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1608526","volume":"15","author":"N Zhang","year":"2025","unstructured":"Zhang N et al (2025) Identification and functional characterization of a novel Acinetobacter pittii bacteriophage-encoded depolymerase. Front Cell Infect Microbiol 15:1608526","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"4778_CR29","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1080\/21505594.2020.1867468","volume":"12","author":"P Li","year":"2021","unstructured":"Li P et al (2021) Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: an epidemiological, genomic and functional study. Virulence 12(1):377\u2013388","journal-title":"Virulence"},{"key":"4778_CR30","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaz1529","author":"Q Cao","year":"2020","unstructured":"Cao Q et al (2020) Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.aaz1529","journal-title":"Sci Signal"},{"key":"4778_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7100461","author":"M Elbediwi","year":"2019","unstructured":"Elbediwi M et al (2019) Global burden of colistin-resistant bacteria: mobilized colistin resistance genes study (1980-2018). Microorganisms. https:\/\/doi.org\/10.3390\/microorganisms7100461","journal-title":"Microorganisms"},{"key":"4778_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2025.111540","volume":"446","author":"H Cai","year":"2026","unstructured":"Cai H et al (2026) Co-occurrence of mcr-1.1, mcr-3.40, and tmexCD1-toprJ1 on a hybrid IncFIB\/IncHI1B plasmid in Klebsiella pneumoniae from pork in Hainan, China. Int J Food Microbiol 446:111540","journal-title":"Int J Food Microbiol"},{"key":"4778_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1622352","volume":"16","author":"D Zhang","year":"2025","unstructured":"Zhang D et al (2025) Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers. Front Microbiol 16:1622352","journal-title":"Front Microbiol"},{"key":"4778_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1619621","volume":"16","author":"S Li","year":"2025","unstructured":"Li S et al (2025) Genomic epidemiology and anti-biofilm mechanisms of Lactobacillus in ST11 carbapenem-resistant Klebsiella pneumoniae in China. Front Microbiol 16:1619621","journal-title":"Front Microbiol"},{"issue":"20","key":"4778_CR35","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.scib.2019.08.024","volume":"64","author":"Y Xu","year":"2019","unstructured":"Xu Y et al (2019) Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme. Sci Bull (Beijing) 64(20):1478\u20131481","journal-title":"Sci Bull (Beijing)"},{"key":"4778_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2025.111578","volume":"449","author":"Y Qiu","year":"2026","unstructured":"Qiu Y et al (2026) Phylogenetic and genomic characterisation of the rare global Salmonella enterica serovar Wandsworth ST1498. Int J Food Microbiol 449:111578","journal-title":"Int J Food Microbiol"},{"issue":"1","key":"4778_CR37","doi-asserted-by":"publisher","first-page":"2576588","DOI":"10.1080\/22221751.2025.2576588","volume":"14","author":"K Chen","year":"2025","unstructured":"Chen K et al (2025) Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid. Emerg Microbes Infect 14(1):2576588","journal-title":"Emerg Microbes Infect"},{"key":"4778_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262311518","author":"EK Idrees","year":"2025","unstructured":"Idrees EK et al (2025) Genomic characterization and resistance mechanisms of carbapenem-resistant Klebsiella pneumoniae ST101 isolates from Saudi Arabia. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms262311518","journal-title":"Int J Mol Sci"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04778-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-04778-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04778-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:42:08Z","timestamp":1776746528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-026-04778-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4778"],"URL":"https:\/\/doi.org\/10.1007\/s00284-026-04778-5","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"7 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was retrospective in nature, so informed consent was waived. The patient treatment information has been de-identified and is in compliance with the Helsinki Declaration. All experiments strictly followed relevant guidelines and regulations, and the ethical protocol was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang University (Approval No: IIT20230479B).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"181"}}