{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:51:44Z","timestamp":1781693504375,"version":"3.54.5"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100012117","name":"Lady Tata Memorial Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["No. 5\/4\/6\/17\/OPH\/2020-NCD-II"],"award-info":[{"award-number":["No. 5\/4\/6\/17\/OPH\/2020-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00284-026-04893-3","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:52:04Z","timestamp":1777787524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunotherapy in Ocular Fungal Infections: Advances and Emerging Strategies"],"prefix":"10.1007","volume":"83","author":[{"given":"Agimanailiu","family":"Khapuinamai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joveeta","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"issue":"3","key":"4893_CR1","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","volume":"21","author":"L Brown","year":"2021","unstructured":"Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW (2021) The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis 21(3):e49\u2013e57. https:\/\/doi.org\/10.1016\/S1473-3099(20)30448-5","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"4893_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-11-39","volume":"11","author":"B Rautaraya","year":"2011","unstructured":"Rautaraya B, Sharma S, Kar S, Das S, Sahu SK (2011) Diagnosis and treatment outcome of mycotic keratitis at a tertiary eye care center in eastern India. BMC Ophthalmol 11(1):39. https:\/\/doi.org\/10.1186\/1471-2415-11-39","journal-title":"BMC Ophthalmol"},{"issue":"3","key":"4893_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3109\/02713683.2010.533810","volume":"36","author":"A Kalkanci","year":"2011","unstructured":"Kalkanci A, Ozdek S (2011) Ocular fungal infections. Curr Eye Res 36(3):179\u2013189. https:\/\/doi.org\/10.3109\/02713683.2010.533810","journal-title":"Curr Eye Res"},{"issue":"3","key":"4893_CR4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1128\/CMR.00113-16","volume":"30","author":"ML Durand","year":"2017","unstructured":"Durand ML (2017) Bacterial and fungal endophthalmitis. Clin Microbiol Rev 30(3):597\u2013613. https:\/\/doi.org\/10.1128\/CMR.00113-16","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"4893_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-023-03536-6","volume":"205","author":"P Reginatto","year":"2023","unstructured":"Reginatto P, Agostinetto GJ, Fuentefria RDN, Marinho DR, Pizzol MD, Fuentefria AM (2023) Eye fungal infections: a mini review. Arch Microbiol 205(6):236. https:\/\/doi.org\/10.1007\/s00203-023-03536-6","journal-title":"Arch Microbiol"},{"issue":"3","key":"4893_CR6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/1469-0691.12126","volume":"19","author":"PA Thomas","year":"2013","unstructured":"Thomas PA, Kaliamurthy J (2013) Mycotic keratitis: epidemiology, diagnosis and management. Clin Microbiol Infect 19(3):210\u2013220. https:\/\/doi.org\/10.1111\/1469-0691.12126","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"4893_CR7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1128\/CMR.13.4.662","volume":"13","author":"SA Klotz","year":"2000","unstructured":"Klotz SA, Penn CC, Negvesky GJ, Butrus SI (2000) Fungal and parasitic infections of the eye. Clin Microbiol Rev 13(4):662\u2013685. https:\/\/doi.org\/10.1128\/CMR.13.4.662","journal-title":"Clin Microbiol Rev"},{"key":"4893_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103802","volume":"138","author":"L Niu","year":"2020","unstructured":"Niu L, Liu X, Ma Z, Yin Y, Sun L, Yang L, Zheng Y (2020) Fungal keratitis: pathogenesis, diagnosis and prevention. Microb Pathog 138:103802. https:\/\/doi.org\/10.1016\/j.micpath.2019.103802","journal-title":"Microb Pathog"},{"issue":"3","key":"4893_CR9","doi-asserted-by":"publisher","first-page":"768","DOI":"10.4103\/ijo.IJO_2329_21","volume":"70","author":"T Das","year":"2022","unstructured":"Das T, Joseph J, Jakati S, Sharma S, Velpandian T, Padhy SK, Das VA, Shivaji S, Nayak S, Behera UC, Mishra DK, Gandhi J, Dave VP, Pathengay A (2022) Understanding the science of fungal endophthalmitis - AIOS 2021 Sengamedu Srinivas Badrinath Endowment Lecture. Indian J Ophthalmol 70(3):768\u2013777. https:\/\/doi.org\/10.4103\/ijo.IJO_2329_21","journal-title":"Indian J Ophthalmol"},{"issue":"9","key":"4893_CR10","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1021\/acsinfecdis.4c00442","volume":"10","author":"H Bihaniya","year":"2024","unstructured":"Bihaniya H, Rudraprasad D, Joseph J (2024) Pathobiology of fungal endophthalmitis: a major review. ACS Infect Dis 10(9):3126\u20133137. https:\/\/doi.org\/10.1021\/acsinfecdis.4c00442","journal-title":"ACS Infect Dis"},{"issue":"4","key":"4893_CR11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.4.44","volume":"65","author":"A Khapuinamai","year":"2024","unstructured":"Khapuinamai A, Rudraprasad D, Pandey S, Gandhi J, Mishra DK, Joseph J (2024) Global transcriptomic profiling of innate and adaptive immunity during Aspergillus flavus endophthalmitis in a murine model. Invest Ophthalmol Vis Sci 65(4):44. https:\/\/doi.org\/10.1167\/iovs.65.4.44","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"40","key":"4893_CR12","doi-asserted-by":"publisher","first-page":"41491","DOI":"10.1021\/acsomega.4c05081","volume":"9","author":"A Khapuinamai","year":"2024","unstructured":"Khapuinamai A, Rudraprasad D, Pandey S, Mishra DK, Joseph J (2024) Unveiling the innate and adaptive immunity interplay: global transcriptomic profiling of the host immune response in Candida albicans endophthalmitis in a murine model. ACS Omega 9(40):41491\u201341503. https:\/\/doi.org\/10.1021\/acsomega.4c05081","journal-title":"ACS Omega"},{"issue":"6","key":"4893_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/jof7060451","volume":"7","author":"G Karavalakis","year":"2021","unstructured":"Karavalakis G, Yannaki E, Papadopoulou A (2021) Reinforcing the immunocompromised host defense against fungi: progress beyond the current state of the art. J Fungi 7(6):451. https:\/\/doi.org\/10.3390\/jof7060451","journal-title":"J Fungi"},{"issue":"10","key":"4893_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/jof8101078","volume":"8","author":"MC Ram\u00edrez-Soto","year":"2022","unstructured":"Ram\u00edrez-Soto MC, Bonifaz A (2022) Ocular fungal infections. J Fungi 8(10):1078. https:\/\/doi.org\/10.3390\/jof8101078","journal-title":"J Fungi"},{"issue":"7","key":"4893_CR15","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/bjo.2007.132886","volume":"92","author":"SM Hariprasad","year":"2008","unstructured":"Hariprasad SM, Mieler WF, Lin TK, Sponsel WE, Graybill JR (2008) Voriconazole in the treatment of fungal eye infections: a review of current literature. Br J Ophthalmol 92(7):871\u2013878. https:\/\/doi.org\/10.1136\/bjo.2007.132886","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"4893_CR16","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1001\/archopht.125.6.789","volume":"125","author":"P Lalitha","year":"2007","unstructured":"Lalitha P, Shapiro BL, Srinivasan M, Prajna NV, Acharya NR, Lietman TM (2007) Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis. Arch Ophthalmol 125(6):789\u2013793. https:\/\/doi.org\/10.1001\/archopht.125.6.789","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"4893_CR17","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/sj.eye.6700557","volume":"17","author":"PA Thomas","year":"2003","unstructured":"Thomas PA (2003) Fungal infections of the cornea. Eye 17(8):852\u2013862. https:\/\/doi.org\/10.1038\/sj.eye.6700557","journal-title":"Eye"},{"issue":"4","key":"4893_CR18","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.ajo.2011.03.023","volume":"152","author":"N Sharma","year":"2011","unstructured":"Sharma N, Chacko J, Velpandian T, Titiyal JS, Sinha R, Satpathy G (2011) Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: a randomized clinical trial. Am J Ophthalmol 152(4):597\u2013602. https:\/\/doi.org\/10.1016\/j.ajo.2011.03.023","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"4893_CR19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cmi.2017.04.010","volume":"23","author":"ML Durand","year":"2017","unstructured":"Durand ML (2017) Endophthalmitis. Clin Microbiol Infect 23(9):497\u2013503. https:\/\/doi.org\/10.1016\/j.cmi.2017.04.010","journal-title":"Clin Microbiol Infect"},{"issue":"9","key":"4893_CR20","doi-asserted-by":"publisher","first-page":"5531","DOI":"10.4049\/jimmunol.1001992","volume":"185","author":"SM Leal Jr","year":"2010","unstructured":"Leal SM Jr, Cowden S, Hsia YC et al (2010) Distinct roles for Dectin-1 and TLR2 in host defense against Candida albicans in the cornea and retina. J Immunol 185(9):5531\u20135538. https:\/\/doi.org\/10.4049\/jimmunol.1001992","journal-title":"J Immunol"},{"issue":"12","key":"4893_CR21","first-page":"7939","volume":"56","author":"SM Leal Jr","year":"2015","unstructured":"Leal SM Jr, Roy S, Vareechon C et al (2015) Targeting IL-1\u03b2 reduces neutrophil recruitment and fungal burden in a mouse model of Candida endophthalmitis. Invest Ophthalmol Vis Sci 56(12):7939\u20137946","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4893_CR22","first-page":"502","volume":"18","author":"T Gao","year":"2012","unstructured":"Gao T, Li Q, Liu Y et al (2012) TLR4-mediated activation of the NF-\u03baB pathway contributes to the inflammatory response in fungal keratitis. Mol Vis 18:502\u2013510","journal-title":"Mol Vis"},{"issue":"9","key":"4893_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7090297","volume":"7","author":"N Gupta","year":"2019","unstructured":"Gupta N, Singh PK, Revankar SG, Chandrasekar PH, Kumar A (2019) Pathobiology of Aspergillus fumigatus endophthalmitis in immunocompetent and immunocompromised mice. Microorganisms 7(9):297. https:\/\/doi.org\/10.3390\/microorganisms7090297","journal-title":"Microorganisms"},{"key":"4893_CR24","doi-asserted-by":"publisher","unstructured":"Leal SM Jr, Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E (2010) Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. PLoS Pathog 6(7):e1000976. https:\/\/doi.org\/10.1371\/journal.ppat.1000976","DOI":"10.1371\/journal.ppat.1000976"},{"issue":"1\u20132","key":"4893_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jneuroim.2004.04.018","volume":"153","author":"MV Kumar","year":"2004","unstructured":"Kumar MV, Nagineni CN, Chin MS, Hooks JJ, Detrick B (2004) Innate immunity in the retina: toll-like receptor (TLR) signaling in human retinal pigment epithelial cells. J Neuroimmunol 153(1\u20132):7\u201315. https:\/\/doi.org\/10.1016\/j.jneuroim.2004.04.018","journal-title":"J Neuroimmunol"},{"issue":"5","key":"4893_CR26","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1177\/1753425916645392","volume":"22","author":"FS Yoshikawa","year":"2016","unstructured":"Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S (2016) Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun 22(5):316\u2013324. https:\/\/doi.org\/10.1177\/1753425916645392","journal-title":"Innate Immun"},{"issue":"8","key":"4893_CR27","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1046\/j.1462-5822.2003.00301.x","volume":"5","author":"A Meier","year":"2003","unstructured":"Meier A, Kirschning CJ, Nikolaus T, Wagner H, Heesemann J, Ebel F (2003) Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 5(8):561\u2013570","journal-title":"Cell Microbiol"},{"issue":"3","key":"4893_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030162","volume":"6","author":"J Gandhi","year":"2020","unstructured":"Gandhi J, Naik P, Kaur I, Kumar A, Joseph J (2020) Microglial response to Aspergillus flavus and Candida albicans: implications in endophthalmitis. J Fungi 6(3):162. https:\/\/doi.org\/10.3390\/jof6030162","journal-title":"J Fungi"},{"issue":"3","key":"4893_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2021.101136","volume":"31","author":"J Gandhi","year":"2021","unstructured":"Gandhi J, Joseph J (2021) Differential inflammatory response to Aspergillus flavus and Candida albicans infection in human retinal pigment epithelial cells: role in treatment of endophthalmitis. J Mycol Med 31(3):101136. https:\/\/doi.org\/10.1016\/j.mycmed.2021.101136","journal-title":"J Mycol Med"},{"issue":"4","key":"4893_CR30","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3980\/j.issn.2222-3959.2015.04.09","volume":"8","author":"CC Zhu","year":"2015","unstructured":"Zhu CC, Zhao GQ, Lin J, Hu LT, Xu Q, Peng XD, Wang X, Qiu S (2015) Dectin-1 agonist curdlan modulates innate immunity to Aspergillus fumigatus in human corneal epithelial cells. Int J Ophthalmol 8(4):690\u2013696. https:\/\/doi.org\/10.3980\/j.issn.2222-3959.2015.04.09","journal-title":"Int J Ophthalmol"},{"issue":"3","key":"4893_CR31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/eye.2017.241","volume":"32","author":"P Yerramothu","year":"2018","unstructured":"Yerramothu P, Vijay AK, Willcox MDP (2018) Inflammasomes, the eye and anti-inflammasome therapy. Eye (Lond) 32(3):491\u2013505. https:\/\/doi.org\/10.1038\/eye.2017.241","journal-title":"Eye (Lond)"},{"issue":"5","key":"4893_CR32","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/ACI.0000000000001004","volume":"24","author":"GS Stinnett","year":"2024","unstructured":"Stinnett GS, Kuo CH, Ono SJ (2024) Impact of inflammasomes on the ocular surface. Curr Opin Allergy Clin Immunol 24(5):368\u2013374. https:\/\/doi.org\/10.1097\/ACI.0000000000001004","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"3","key":"4893_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009358","volume":"17","author":"B Briard","year":"2021","unstructured":"Briard B, Malireddi RKS, Kanneganti TD (2021) Role of inflammasomes\/pyroptosis and PANoptosis during fungal infection. PLoS Pathog 17(3):e1009358. https:\/\/doi.org\/10.1371\/journal.ppat.1009358","journal-title":"PLoS Pathog"},{"key":"4893_CR34","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.mib.2021.07.018","volume":"63","author":"B Ratitong","year":"2021","unstructured":"Ratitong B, Pearlman E (2021) Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections - the role of neutrophils in fungal killing, tissue damage and cytokine production. Curr Opin Microbiol 63:195\u2013203. https:\/\/doi.org\/10.1016\/j.mib.2021.07.018","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"4893_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nri1255","volume":"4","author":"L Romani","year":"2004","unstructured":"Romani L (2004) Immunity to fungal infections. Nat Rev Immunol 4(1):1\u201323. https:\/\/doi.org\/10.1038\/nri1255","journal-title":"Nat Rev Immunol"},{"key":"4893_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101753","volume":"67","author":"S Abbondante","year":"2023","unstructured":"Abbondante S, Leal SM, Clark HL, Ratitong B, Sun Y, Ma LJ, Pearlman E (2023) Immunity to pathogenic fungi in the eye. Semin Immunol 67:101753. https:\/\/doi.org\/10.1016\/j.smim.2023.101753","journal-title":"Semin Immunol"},{"issue":"6","key":"4893_CR37","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1167\/iovs.08-3104","volume":"50","author":"H Zhang","year":"2009","unstructured":"Zhang H, Chen H, Niu J, Wang Y, Xie L (2009) Role of adaptive immunity in the pathogenesis of Candida albicans keratitis. Invest Ophthalmol Vis Sci 50(6):2653\u20132659. https:\/\/doi.org\/10.1167\/iovs.08-3104","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"4893_CR38","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41577-022-00826-w","volume":"23","author":"MS Lionakis","year":"2023","unstructured":"Lionakis MS, Drummond RA, Hohl TM (2023) Immune responses to human fungal pathogens and therapeutic prospects. Nat Rev Immunol 23(7):433\u2013452. https:\/\/doi.org\/10.1038\/s41577-022-00826-w","journal-title":"Nat Rev Immunol"},{"key":"4893_CR39","doi-asserted-by":"publisher","unstructured":"Karthikeyan RS, Leal SM Jr, Prajna NV, Dharmalingam K, Geiser DM, Pearlman E, Lalitha P (2011) Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or Fusarium. J Infect Dis 204(6):942\u2013950. https:\/\/doi.org\/10.1093\/infdis\/jir426","DOI":"10.1093\/infdis\/jir426"},{"key":"4893_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106649","volume":"85","author":"L Peng","year":"2020","unstructured":"Peng L, Zhong J, Xiao Y, Wang B, Li S, Deng Y, He D, Yuan J (2020) Therapeutic effects of an anti-IL-6 antibody in fungal keratitis: macrophage inhibition and T cell subset regulation. Int Immunopharmacol 85:106649. https:\/\/doi.org\/10.1016\/j.intimp.2020.106649","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"4893_CR41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/BOR.0000000000000255","volume":"28","author":"X Liu","year":"2016","unstructured":"Liu X, Jones GW, Choy EH, Jones SA (2016) The biology behind interleukin-6 targeted interventions. Curr Opin Rheumatol 28(2):152\u2013160. https:\/\/doi.org\/10.1097\/BOR.0000000000000255","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"4893_CR42","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/eji.201343604","volume":"44","author":"N Whibley","year":"2014","unstructured":"Whibley N, Maccallum DM, Vickers MA, Zafreen S, Waldmann H, Hori S, Gaffen SL, Gow NA, Barker RN, Hall AM (2014) Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge. Eur J Immunol 44(4):1069\u20131083. https:\/\/doi.org\/10.1002\/eji.201343604","journal-title":"Eur J Immunol"},{"issue":"8","key":"4893_CR43","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1136\/bjophthalmol-2020-316329","volume":"105","author":"I Mohammed","year":"2021","unstructured":"Mohammed I, Mohanty D, Said DG et al (2021) Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. Br J Ophthalmol 105(8):1172\u20131177. https:\/\/doi.org\/10.1136\/bjophthalmol-2020-316329","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"4893_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.835843","volume":"16","author":"DSJ Ting","year":"2022","unstructured":"Ting DSJ, Mohammed I, Lakshminarayanan R, Beuerman RW, Dua HS (2022) Host defense peptides at the ocular surface: roles in health and major diseases, and therapeutic potentials. Front Med (Lausanne) 16(9):835843. https:\/\/doi.org\/10.3389\/fmed.2022.835843","journal-title":"Front Med (Lausanne)"},{"issue":"13","key":"4893_CR45","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1007\/s00018-011-0713-7","volume":"68","author":"SS Kolar","year":"2011","unstructured":"Kolar SS, McDermott AM (2011) Role of host-defence peptides in eye diseases. Cell Mol Life Sci 68(13):2201\u20132213. https:\/\/doi.org\/10.1007\/s00018-011-0713-7","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"4893_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00283","volume":"20","author":"XL Luo","year":"2019","unstructured":"Luo XL, Li JX, Huang HR, Duan JL, Dai RX, Tao RJ, Yang L, Hou JY, Jia XM, Xu JF (2019) LL37 inhibits Aspergillus fumigatus infection via directly binding to the fungus and preventing excessive inflammation. Front Immunol 20(10):283. https:\/\/doi.org\/10.3389\/fimmu.2019.00283","journal-title":"Front Immunol"},{"issue":"7","key":"4893_CR47","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12275-014-3630-2","volume":"52","author":"PW Tsai","year":"2014","unstructured":"Tsai PW, Cheng YL, Hsieh WP, Lan CY (2014) Responses of Candida albicans to the human antimicrobial peptide LL-37. J Microbiol 52(7):581\u2013589. https:\/\/doi.org\/10.1007\/s12275-014-3630-2","journal-title":"J Microbiol"},{"issue":"9","key":"4893_CR48","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1002\/eji.201444490","volume":"44","author":"X Liu","year":"2014","unstructured":"Liu X, Gao N, Dong C et al (2014) Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection. Eur J Immunol 44(9):2667\u20132679. https:\/\/doi.org\/10.1002\/eji.201444490","journal-title":"Eur J Immunol"},{"issue":"13","key":"4893_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fmic.2022.857735","volume":"2","author":"AH Shannon","year":"2022","unstructured":"Shannon AH, Adelman SA, Hisey EA, Potnis SS, Rozo V, Yung MW, Li JY, Murphy CJ, Thomasy SM, Leonard BC (2022) Antimicrobial peptide expression at the ocular surface and their therapeutic use in the treatment of microbial keratitis. Front Microbiol 2(13):857735. https:\/\/doi.org\/10.3389\/fmic.2022.857735","journal-title":"Front Microbiol"},{"issue":"10","key":"4893_CR50","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.18240\/ijo.2023.10.11","volume":"16","author":"JS Wang","year":"2023","unstructured":"Wang JS, Peng X, Zhao Z, Wang C, Xie HT, Zhang MC (2023) Differential expression of antimicrobial peptides in human fungal keratitis. Int J Ophthalmol 16(10):1630\u20131635. https:\/\/doi.org\/10.18240\/ijo.2023.10.11","journal-title":"Int J Ophthalmol"},{"issue":"3","key":"4893_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105701","volume":"300","author":"S Roy","year":"2024","unstructured":"Roy S, Bhogapurapu B, Chandra S, Biswas K, Mishra P, Ghosh A, Bhunia A (2024) Host antimicrobial peptide S100A12 disrupts the fungal membrane by direct binding and inhibits growth and biofilm formation of Fusarium species. J Biol Chem 300(3):105701. https:\/\/doi.org\/10.1016\/j.jbc.2024.105701","journal-title":"J Biol Chem"},{"issue":"8","key":"4893_CR52","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1128\/IAI.00179-13","volume":"81","author":"SS Kolar","year":"2013","unstructured":"Kolar SS, Baidouri H, Hanlon S, McDermott AM (2013) Protective role of murine \u03b2-defensins 3 and 4 and cathelin-related antimicrobial peptide in Fusarium solani keratitis. Infect Immun 81(8):2669\u20132677. https:\/\/doi.org\/10.1128\/IAI.00179-13","journal-title":"Infect Immun"},{"issue":"2","key":"4893_CR53","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.hoc.2018.12.004","volume":"33","author":"AW Silk","year":"2019","unstructured":"Silk AW, Margolin K (2019) Cytokine therapy. Hematol Oncol Clin North Am 33(2):261\u2013274. https:\/\/doi.org\/10.1016\/j.hoc.2018.12.004","journal-title":"Hematol Oncol Clin North Am"},{"key":"4893_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5230716","volume":"2020","author":"Y Qian","year":"2020","unstructured":"Qian Y, Zhang M (2020) The functional roles of IL-33\/ST2 axis in ocular diseases. Mediators Inflamm 2020:5230716. https:\/\/doi.org\/10.1155\/2020\/5230716","journal-title":"Mediators Inflamm"},{"key":"4893_CR55","doi-asserted-by":"publisher","unstructured":"You J, Lin J, Zhou YF, et al. (2019) Role of the IL-33\/ST2\/p38 signaling pathway in the immune response of corneal epithelial cells to Aspergillus fumigatus infection. Int J Ophthalmol. 12(4):549\u2013556. Published 2019 Apr 18. https:\/\/doi.org\/10.18240\/ijo.2019.04.04","DOI":"10.18240\/ijo.2019.04.04"},{"key":"4893_CR56","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00183-25","author":"Z Ahmad","year":"2025","unstructured":"Ahmad Z, Singh S, Rudraprasad D, Joseph J, Singh NK, Kumar A (2025) Proteomic profiling reveals immunomodulatory role of IL-33 in ocular bacterial and fungal infections. Infect Immun. https:\/\/doi.org\/10.1128\/iai.00183-25","journal-title":"Infect Immun"},{"issue":"1","key":"4893_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-166","volume":"14","author":"CE Delsing","year":"2014","unstructured":"Delsing CE, Gresnigt MS, Leentjens J, Preijers F, Frager FA, Kox M, Monneret G, Venet F, Bleeker-Rovers CP, van de Veerdonk FL, Pickkers P, Pachot A, Kullberg BJ, Netea MG (2014) Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series. BMC Infect Dis 14(1):166. https:\/\/doi.org\/10.1186\/1471-2334-14-166","journal-title":"BMC Infect Dis"},{"issue":"1","key":"4893_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01511-0","volume":"9","author":"JH Ko","year":"2023","unstructured":"Ko JH, Kim S, Ryu JS, Song HJ, Oh JY (2023) Interferon-\u03b3 elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells. Cell Death Discov 9(1):209. https:\/\/doi.org\/10.1038\/s41420-023-01511-0","journal-title":"Cell Death Discov"},{"issue":"1","key":"4893_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-025-00461-1","volume":"15","author":"SSEM Shaban","year":"2025","unstructured":"Shaban SSEM, Safwat HM, Abdelmohymen AM, Hassan DA, Mansour MN, Mohammed HS, Seliem N, El Attar S, Amin DR, Khirala SKA, Ghamry AA, Anany MGEDA, Mohammed SF (2025) Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients. J Ophthalmic Inflamm Infect 15(1):12. https:\/\/doi.org\/10.1186\/s12348-025-00461-1","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"4893_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.849990","volume":"9","author":"J Alam","year":"2022","unstructured":"Alam J, Yazdanpanah G, Ratnapriya R, Borcherding N, de Paiva CS, Li D, Guimaraes de Souza R, Yu Z, Pflugfelder SC (2022) IL-17 producing lymphocytes cause dry eye and corneal disease with aging in RXR\u03b1 mutant mouse. Front Med 9:849990. https:\/\/doi.org\/10.3389\/fmed.2022.849990","journal-title":"Front Med"},{"issue":"2","key":"4893_CR61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1620\/tjem.247.87","volume":"247","author":"Y Li","year":"2019","unstructured":"Li Y, Zhou Y (2019) Interleukin-17: the role for pathological angiogenesis in ocular neovascular diseases. Tohoku J Exp Med 247(2):87\u201398. https:\/\/doi.org\/10.1620\/tjem.247.87","journal-title":"Tohoku J Exp Med"},{"issue":"3","key":"4893_CR62","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1080\/15384101.2018.1556059","volume":"18","author":"XH Qin","year":"2019","unstructured":"Qin XH, Ma X, Fang SF, Zhang ZZ, Lu JM (2019) IL-17 produced by Th17 cells alleviates the severity of fungal keratitis by suppressing CX43 expression in corneal peripheral vascular endothelial cells. Cell Cycle 18(3):274\u2013287. https:\/\/doi.org\/10.1080\/15384101.2018.1556059","journal-title":"Cell Cycle"},{"issue":"7","key":"4893_CR63","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.18240\/ijo.2023.07.20","volume":"16","author":"SX Fan","year":"2023","unstructured":"Fan SX, Wang WH, Zeng P, Huang KZ, Hu YX, Wang J, Li YQ, Xiao JH (2023) Ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation. Int J Ophthalmol 16(7):1138\u20131144. https:\/\/doi.org\/10.18240\/ijo.2023.07.20","journal-title":"Int J Ophthalmol"},{"issue":"3","key":"4893_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030173","volume":"6","author":"DE Monta\u00f1o","year":"2020","unstructured":"Monta\u00f1o DE, Voigt K (2020) Host immune defense upon fungal infections with Mucorales: pathogen-immune cell interactions as drivers of inflammatory responses. J Fungi Basel 6(3):173. https:\/\/doi.org\/10.3390\/jof6030173","journal-title":"J Fungi Basel"},{"issue":"Suppl 2","key":"4893_CR65","doi-asserted-by":"publisher","first-page":"S342","DOI":"10.1086\/513857","volume":"179","author":"RK Root","year":"1999","unstructured":"Root RK, Dale DC (1999) Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients. J Infect Dis 179(Suppl 2):S342\u2013S352. https:\/\/doi.org\/10.1086\/513857","journal-title":"J Infect Dis"},{"issue":"8","key":"4893_CR66","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1093\/infdis\/jiw054","volume":"213","author":"S Kasahara","year":"2016","unstructured":"Kasahara S, Jhingran A, Dhingra S, Salem A, Cramer RA, Hohl TM (2016) Role of granulocyte-macrophage colony-stimulating factor signaling in regulating neutrophil antifungal activity and the oxidative burst during respiratory fungal challenge. J Infect Dis 213(8):1289\u20131298. https:\/\/doi.org\/10.1093\/infdis\/jiw054. (Epub 2016 Feb 9. PMID: 26908736; PMCID: PMC4799674.)","journal-title":"J Infect Dis"},{"issue":"3","key":"4893_CR67","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.sjopt.2013.06.007","volume":"27","author":"A Nassar","year":"2013","unstructured":"Nassar A, Tabbara KF, Aljurf M (2013) Ocular manifestations of graft-versus-host disease. Saudi J Ophthalmol 27(3):215\u2013222. https:\/\/doi.org\/10.1016\/j.sjopt.2013.06.007","journal-title":"Saudi J Ophthalmol"},{"issue":"Suppl 3","key":"4893_CR68","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1086\/430000","volume":"41","author":"SG Filler","year":"2005","unstructured":"Filler SG, Yeaman MR, Sheppard DC (2005) Tumor necrosis factor inhibition and invasive fungal infections. Clin Infect Dis 41(Suppl 3):S208\u2013S212. https:\/\/doi.org\/10.1086\/430000","journal-title":"Clin Infect Dis"},{"issue":"12","key":"4893_CR69","doi-asserted-by":"publisher","first-page":"5999","DOI":"10.1128\/IAI.66.12.5999-6003.1998","volume":"66","author":"E Roilides","year":"1998","unstructured":"Roilides E, Dimitriadou-Georgiadou A, Sein T, Kadiltsoglou I, Walsh TJ (1998) Tumor necrosis factor alpha enhances antifungal activities of polymorphonuclear and mononuclear phagocytes against Aspergillus fumigatus. Infect Immun 66(12):5999\u20136003. https:\/\/doi.org\/10.1128\/IAI.66.12.5999-6003.1998","journal-title":"Infect Immun"},{"issue":"3","key":"4893_CR70","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/02713683.2019.1639765","volume":"45","author":"S Shukla","year":"2020","unstructured":"Shukla S, Shanbhag SS, Tavakkoli F, Varma S, Singh V, Basu S (2020) Limbal epithelial and mesenchymal stem cell therapy for corneal regeneration. Curr Eye Res 45(3):265\u2013277. https:\/\/doi.org\/10.1080\/02713683.2019.1639765","journal-title":"Curr Eye Res"},{"key":"4893_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.110027","volume":"247","author":"V Tati","year":"2024","unstructured":"Tati V, Muthukumar VS, Shukla S (2024) Mesenchymal vs. epithelial extracellular vesicles in corneal epithelial repair, apoptosis, and immunomodulation: An in vitro study. Exp Eye Res 247:110027. https:\/\/doi.org\/10.1016\/j.exer.2024.110027","journal-title":"Exp Eye Res"},{"issue":"6","key":"4893_CR72","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/2211-5463.13804","volume":"14","author":"V Tati","year":"2024","unstructured":"Tati V, Mitra S, Basu S, Shukla S (2024) Bone marrow mesenchymal stem cell-derived extracellular vesicles promote corneal epithelial repair and suppress apoptosis via modulation of Caspase-3 in vitro. FEBS Open Bio 14(6):968\u2013982. https:\/\/doi.org\/10.1002\/2211-5463.13804","journal-title":"FEBS Open Bio"},{"key":"4893_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.109863","volume":"242","author":"V Tati","year":"2024","unstructured":"Tati V, Das P, Joseph J, Bagga B, Shukla S (2024) Mesenchymal stem cell-based adjunctive therapy for Pseudomonas aeruginosa-induced keratitis: a proof-of-concept in-vitro study. Exp Eye Res 242:109863. https:\/\/doi.org\/10.1016\/j.exer.2024.109863","journal-title":"Exp Eye Res"},{"issue":"2","key":"4893_CR74","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020558","volume":"19","author":"SW Teh","year":"2018","unstructured":"Teh SW, Mok PL, Abd Rashid M, Bastion MC, Ibrahim N, Higuchi A, Murugan K, Mariappan R, Subbiah SK (2018) Recent updates on treatment of ocular microbial infections by stem cell therapy: a review. Int J Mol Sci 19(2):558. https:\/\/doi.org\/10.3390\/ijms19020558","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4893_CR75","first-page":"3243","volume":"41","author":"SM Whitcup","year":"2000","unstructured":"Whitcup SM (2000) The double-edged ocular immune response: the Cogan lecture. Invest Ophthalmol Vis Sci 41(11):3243\u20133248","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4893_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00037","volume":"7","author":"AW Taylor","year":"2016","unstructured":"Taylor AW (2016) Ocular immune privilege and transplantation. Front Immunol 7:37. https:\/\/doi.org\/10.3389\/fimmu.2016.00037","journal-title":"Front Immunol"},{"issue":"2","key":"4893_CR77","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1189\/jlb.1102574","volume":"74","author":"JW Streilein","year":"2003","unstructured":"Streilein JW (2003) Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukoc Biol 74(2):179\u2013185. https:\/\/doi.org\/10.1189\/jlb.1102574","journal-title":"J Leukoc Biol"},{"issue":"2","key":"4893_CR78","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-023-02516-9","volume":"24","author":"S Ahmed","year":"2023","unstructured":"Ahmed S, Amin MM, Sayed S (2023) Ocular drug delivery: a comprehensive review. AAPS PharmSciTech 24(2):66. https:\/\/doi.org\/10.1208\/s12249-023-02516-9","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"4893_CR79","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1124\/jpet.119.256933","volume":"370","author":"V Gote","year":"2019","unstructured":"Gote V, Sikder S, Sicotte J, Pal D (2019) Ocular drug delivery: present innovations and future challenges. J Pharmacol Exp Ther 370(3):602\u2013624. https:\/\/doi.org\/10.1124\/jpet.119.256933","journal-title":"J Pharmacol Exp Ther"},{"issue":"9","key":"4893_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11090460","volume":"11","author":"EB Souto","year":"2019","unstructured":"Souto EB, Dias-Ferreira J, L\u00f3pez-Machado A, Ettcheto M, Cano A, Camins Espuny A, Espina M, Garcia ML, S\u00e1nchez-L\u00f3pez E (2019) Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents. Pharmaceutics 11(9):460. https:\/\/doi.org\/10.3390\/pharmaceutics11090460","journal-title":"Pharmaceutics"},{"issue":"1","key":"4893_CR81","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/0974-9233.106384","volume":"20","author":"Q Xu","year":"2013","unstructured":"Xu Q, Kambhampati SP, Kannan RM (2013) Nanotechnology approaches for ocular drug delivery. Middle East Afr J Ophthalmol 20(1):26\u201337. https:\/\/doi.org\/10.4103\/0974-9233.106384","journal-title":"Middle East Afr J Ophthalmol"},{"key":"4893_CR82","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00469","volume":"10","author":"M Ademe","year":"2020","unstructured":"Ademe M (2020) Immunomodulation for the treatment of fungal infections: opportunities and challenges. Front Cell Infect Microbiol 10:469. https:\/\/doi.org\/10.3389\/fcimb.2020.00469","journal-title":"Front Cell Infect Microbiol"},{"key":"4893_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01431","volume":"11","author":"A Takeda","year":"2020","unstructured":"Takeda A, Yanai R, Murakami Y, Arima M, Sonoda KH (2020) New insights into immunological therapy for retinal disorders. Front Immunol 11:1431. https:\/\/doi.org\/10.3389\/fimmu.2020.01431","journal-title":"Front Immunol"},{"issue":"1","key":"4893_CR84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/b:verc.0000046743.27552.19","volume":"29","author":"HJ Shao","year":"2005","unstructured":"Shao HJ, Chen L, Su YB (2005) DNA fragment encoding human IL-1beta 163-171 peptide enhances the immune responses elicited in mice by DNA vaccine against foot-and-mouth disease. Vet Res Commun 29(1):35\u201346. https:\/\/doi.org\/10.1023\/b:verc.0000046743.27552.19","journal-title":"Vet Res Commun"},{"issue":"10","key":"4893_CR85","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1182\/blood-2003-03-0748","volume":"102","author":"S Bozza","year":"2003","unstructured":"Bozza S, Perruccio K, Montagnoli C et al (2003) A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102(10):3807\u20133814. https:\/\/doi.org\/10.1182\/blood-2003-03-0748","journal-title":"Blood"},{"issue":"5","key":"4893_CR86","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.chom.2012.04.005","volume":"11","author":"RM Roy","year":"2012","unstructured":"Roy RM, Klein BS (2012) Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe 11(5):436\u2013446. https:\/\/doi.org\/10.1016\/j.chom.2012.04.005","journal-title":"Cell Host Microbe"},{"issue":"6","key":"4893_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/jof9060633","volume":"9","author":"MM In\u00e1cio","year":"2023","unstructured":"In\u00e1cio MM, Moreira ALE, Cruz-Leite VRM et al (2023) Fungal vaccine development: state of the art and perspectives using immunoinformatics. J Fungi 9(6):633. https:\/\/doi.org\/10.3390\/jof9060633","journal-title":"J Fungi"},{"key":"4893_CR88","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.biopha.2018.10.075","volume":"109","author":"S Nami","year":"2019","unstructured":"Nami S, Mohammadi R, Vakili M, Khezripour K, Mirzaei H, Morovati H (2019) Fungal vaccines, mechanism of actions and immunology: a comprehensive review. Biomed Pharmacother 109:333\u2013344. https:\/\/doi.org\/10.1016\/j.biopha.2018.10.075","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"4893_CR89","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1021\/acsinfecdis.4c00245","volume":"10","author":"X Gong","year":"2024","unstructured":"Gong X, Wani MY, Al-Bogami AS, Ahmad A, Robinson K, Khan A (2024) The road ahead: advancing antifungal vaccines and addressing fungal infections in the post-COVID world. ACS Infect Dis 10(10):3475\u20133495. https:\/\/doi.org\/10.1021\/acsinfecdis.4c00245","journal-title":"ACS Infect Dis"},{"issue":"11","key":"4893_CR90","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019711","volume":"4","author":"E Santos","year":"2014","unstructured":"Santos E, Levitz SM (2014) Fungal vaccines and immunotherapeutics. Cold Spring Harb Perspect Med 4(11):a019711. https:\/\/doi.org\/10.1101\/cshperspect.a019711","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4893_CR91","doi-asserted-by":"publisher","unstructured":"Edwards JE Jr, Schwartz MM, Schmidt CS et al (2018) A fungal immunotherapeutic vaccine (NDV-3A) for treatment of recurrent vulvovaginal candidiasis-a phase 2 randomized, double-blind, placebo-controlled trial. Clin Infect Dis 66(12):1928\u20131936. https:\/\/doi.org\/10.1093\/cid\/ciy185","DOI":"10.1093\/cid\/ciy185"},{"key":"4893_CR92","doi-asserted-by":"publisher","unstructured":"Ibrahim AS, Spellberg BJ, Avanesian V, Fu Y, Edwards JE Jr. (2006) The anti-Candida vaccine based on the recombinant n-terminal domain of Als1p is broadly active against disseminated candidiasis. Infect Immun 74(5):3039\u20133041. https:\/\/doi.org\/10.1128\/IAI.74.5.3039-3041.2006","DOI":"10.1128\/IAI.74.5.3039-3041.2006"},{"issue":"52","key":"4893_CR93","doi-asserted-by":"publisher","first-page":"7594","DOI":"10.1016\/j.vaccine.2012.10.038","volume":"30","author":"CS Schmidt","year":"2012","unstructured":"Schmidt CS, White CJ, Ibrahim AS et al (2012) NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults. Vaccine 30(52):7594\u20137600. https:\/\/doi.org\/10.1016\/j.vaccine.2012.10.038","journal-title":"Vaccine"},{"issue":"31","key":"4893_CR94","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1016\/j.vaccine.2022.05.057","volume":"40","author":"M Slarve","year":"2022","unstructured":"Slarve M, Holznecht N, Reza H et al (2022) Recombinant Aspergillus fumigatus antigens Asp f 3 and Asp f 9 in liposomal vaccine protect mice against invasive pulmonary aspergillosis. Vaccine 40(31):4160\u20134168. https:\/\/doi.org\/10.1016\/j.vaccine.2022.05.057","journal-title":"Vaccine"},{"issue":"3","key":"4893_CR95","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1293\/tox.2015-0031","volume":"28","author":"M Suzuki","year":"2015","unstructured":"Suzuki M, Kato C, Kato A (2015) Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies. J Toxicol Pathol 28(3):133\u2013139. https:\/\/doi.org\/10.1293\/tox.2015-0031","journal-title":"J Toxicol Pathol"},{"key":"4893_CR96","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403121","volume":"2013","author":"F Bugli","year":"2013","unstructured":"Bugli F, Cacaci M, Martini C et al (2013) Human monoclonal antibody-based therapy in the treatment of invasive candidiasis. Clin Dev Immunol 2013:403121. https:\/\/doi.org\/10.1155\/2013\/403121","journal-title":"Clin Dev Immunol"},{"issue":"7","key":"4893_CR97","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1128\/AAC.47.7.2208-2216.2003","volume":"47","author":"RC Matthews","year":"2003","unstructured":"Matthews RC, Rigg G, Hodgetts S et al (2003) Preclinical assessment of the efficacy of Mycograb, a human recombinant antibody against fungal HSP90. Antimicrob Agents Chemother 47(7):2208\u20132216. https:\/\/doi.org\/10.1128\/AAC.47.7.2208-2216.2003","journal-title":"Antimicrob Agents Chemother"},{"issue":"24","key":"4893_CR98","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1056\/NEJMoa2000024","volume":"382","author":"M Tsai","year":"2020","unstructured":"Tsai M, Thauland TJ, Huang AY et al (2020) Disseminated coccidioidomycosis treated with Interferon-\u03b3 and Dupilumab. N Engl J Med 382(24):2337\u20132343. https:\/\/doi.org\/10.1056\/NEJMoa2000024","journal-title":"N Engl J Med"},{"key":"4893_CR99","doi-asserted-by":"publisher","unstructured":"Rudkin FM, Raziunaite I, Workman H, et al. (2018) Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis [published correction appears in Nat Commun. 2019 Jan 18;10(1):394. https:\/\/doi.org\/10.1038\/s41467-019-08392-x.]. Nat Commun. 9(1):5288. Published 2018 Dec 11. 10.1038\/s41467\u2013018\u201307738\u20131","DOI":"10.1038\/s41467-019-08392-x"},{"issue":"1","key":"4893_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010031","volume":"6","author":"C Boniche","year":"2020","unstructured":"Boniche C, Rossi SA, Kischkel B et al (2020) Immunotherapy against systemic fungal infections based on monoclonal antibodies. J Fungi 6(1):31. https:\/\/doi.org\/10.3390\/jof6010031","journal-title":"J Fungi"},{"issue":"3","key":"4893_CR101","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1021\/acsmaterialslett.4c02327","volume":"7","author":"L Yang","year":"2025","unstructured":"Yang L, Li J, Zhou B, Wang Y (2025) An injectable copolymer for in situ lubrication effectively relieves dry eye disease. ACS Mater Lett 7(3):884\u2013890. https:\/\/doi.org\/10.1021\/acsmaterialslett.4c02327","journal-title":"ACS Mater Lett"},{"key":"4893_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117408","volume":"279","author":"Y Ye","year":"2025","unstructured":"Ye Y, Lu Y, Su H, Tian Y, Jin S, Li G, Yang Y, Jiang L, Zhou Z, Wei X, Tao TH, Sun L (2025) A hybrid bioelectronic retina-probe interface for object recognition. Biosens Bioelectron 279:117408. https:\/\/doi.org\/10.1016\/j.bios.2025.117408","journal-title":"Biosens Bioelectron"},{"issue":"12","key":"4893_CR103","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17121519","volume":"17","author":"A Harada","year":"2025","unstructured":"Harada A, Tanaka R, Otake H, Yoshimura M, Wada T, Nagahama T, Nagai N (2025) Dermal formulation incorporating Isoconazole Nitrate nanoparticles offers high absorption into skin and antimicrobial effect against Candida albicans. Pharmaceutics 17(12):1519. https:\/\/doi.org\/10.3390\/pharmaceutics17121519","journal-title":"Pharmaceutics"},{"key":"4893_CR104","doi-asserted-by":"publisher","unstructured":"Haixu Liu, Yu Wang, Ruiheng Yang, Weijun Li, Huiyang Xiong, Yu Li, Yongping Fu, Shijun Xiao, Dapeng Bao. bioRxiv. Mating-Type Imputation (MTI) provides an efficient tool for the mating-type inference of tetrapolar fungi. https:\/\/doi.org\/10.1101\/2025.09.01.673225","DOI":"10.1101\/2025.09.01.673225"},{"issue":"4","key":"4893_CR105","first-page":"315","volume":"51","author":"MJ Bharathi","year":"2003","unstructured":"Bharathi MJ, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R (2003) Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study. Indian J Ophthalmol 51(4):315\u2013321","journal-title":"Indian J Ophthalmol"},{"key":"4893_CR106","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6395840","volume":"2019","author":"P Manikandan","year":"2019","unstructured":"Manikandan P, Abdel-Hadi A, Randhir Babu Singh Y, Revathi R, Anita R, Banawas S, Bin Dukhyil AA, Alshehri B, Shobana CS, Panneer Selvam K, Narendran V (2019) Fungal keratitis: epidemiology, rapid detection, and antifungal susceptibilities of Fusarium and Aspergillus isolates from corneal scrapings. BioMed Res Int 6395840. https:\/\/doi.org\/10.1155\/2019\/6395840","journal-title":"BioMed Res Int"},{"key":"4893_CR107","doi-asserted-by":"publisher","unstructured":"Taylor PR, Leal SM Jr, Sun Y, Pearlman E (2014) Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils. J Immunol 192(7):3319\u201327. https:\/\/doi.org\/10.4049\/jimmunol.1302235","DOI":"10.4049\/jimmunol.1302235"},{"issue":"5","key":"4893_CR108","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","volume":"12","author":"S EL Andaloussi","year":"2013","unstructured":"EL Andaloussi S, M\u00e4ger I, Breakefield XO, Wood MJ (2013) Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12(5):347\u201357. https:\/\/doi.org\/10.1038\/nrd3978","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"4893_CR109","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","volume":"2","author":"A Patel","year":"2013","unstructured":"Patel A, Cholkar K, Agrahari V, Mitra AK (2013) Ocular drug delivery systems: an overview. World J Pharmacol 2(2):47\u201364. https:\/\/doi.org\/10.5497\/wjp.v2.i2.47","journal-title":"World J Pharmacol"},{"issue":"6","key":"4893_CR110","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2174\/092986710790416290","volume":"17","author":"L Zhang","year":"2010","unstructured":"Zhang L, Pornpattananangku D, Hu CM, Huang CM (2010) Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem 17(6):585\u2013594. https:\/\/doi.org\/10.2174\/092986710790416290","journal-title":"Curr Med Chem"},{"issue":"6","key":"4893_CR111","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.jaip.2023.04.015","volume":"11","author":"SG Tangye","year":"2023","unstructured":"Tangye SG, Puel A (2023) The Th17\/IL-17 axis and host defense against fungal infections. J Allergy Clin Immunol Pract 11(6):1624\u20131634. https:\/\/doi.org\/10.1016\/j.jaip.2023.04.015","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"4893_CR112","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.10203266","volume":"68","author":"I-A Aziz","year":"2023","unstructured":"Aziz I-A, Al-Maqtoofi MY, Burghal AA (2023) Interleukin-17 and immunity of ocular infections. Acta Microbiol Hell 68(4):2319. https:\/\/doi.org\/10.5281\/zenodo.10203266","journal-title":"Acta Microbiol Hell"},{"issue":"1","key":"4893_CR113","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1080\/21501203.2023.2265664","volume":"15","author":"H Bilal","year":"2023","unstructured":"Bilal H, Khan MN, Khan S, Fang W, Chang W, Yin B, Song NJ, Liu Z, Zhang D, Yao F, Wang X, Wang Q, Cai L, Hou B, Wang J, Mao C, Liu L, Zeng Y (2023) Risk of candidiasis associated with Interleukin-17 inhibitors: implications and management. Mycology 15(1):30\u201344. https:\/\/doi.org\/10.1080\/21501203.2023.2265664","journal-title":"Mycology"},{"issue":"7","key":"4893_CR114","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1136\/bjophthalmol-2021-320814","volume":"107","author":"AA Mumtaz","year":"2023","unstructured":"Mumtaz AA, Fischer A, Lutfi F, Matsumoto LR, Atanackovic D, Kolanci ET, Hankey KG, Hardy NM, Yared JA, Kocoglu MH, Rapoport AP, Dahiya S, Li AS, Sunshine SB (2023) Ocular adverse events associated with chimeric antigen receptor T-cell therapy: a case series and review. Br J Ophthalmol 107(7):901\u2013905. https:\/\/doi.org\/10.1136\/bjophthalmol-2021-320814","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"4893_CR115","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myac064","volume":"60","author":"J Gandhi","year":"2022","unstructured":"Gandhi J, Naik MN, Mishra DK, Joseph J (2022) Proteomic profiling of Aspergillus flavus endophthalmitis derived extracellular vesicles in an in-vivo murine model. Med Mycol 60(9):myac064. https:\/\/doi.org\/10.1093\/mmy\/myac064","journal-title":"Med Mycol"},{"key":"4893_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.905867","volume":"13","author":"J Sharma","year":"2022","unstructured":"Sharma J, Mudalagiriyappa S, Nanjappa SG (2022) T cell responses to control fungal infection in an immunological memory lens. Front Immunol 13:905867. https:\/\/doi.org\/10.3389\/fimmu.2022.905867","journal-title":"Front Immunol"},{"issue":"1","key":"4893_CR117","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/09273948.2025.2573739","volume":"34","author":"J Xie","year":"2026","unstructured":"Xie J, Wang Z, Feng X (2026) Targeting dendritic cells: an emerging agent in dry eye disease management. Ocul Immunol Inflamm 34(1):155\u2013165. https:\/\/doi.org\/10.1080\/09273948.2025.2573739","journal-title":"Ocul Immunol Inflamm"},{"issue":"10","key":"4893_CR118","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13102351","volume":"13","author":"JA Jellmayer","year":"2025","unstructured":"Jellmayer JA, Deus AF, Curti Gon\u00e7alves MR, Souza Ferreira L, Manente FA, Pinho Caetano LS, Piccineli FL, Zamber\u00e7o Dos Reis Genari T, Sa\u00e7aki BDC, Pavicic Catalan de Oliveira Campos T, Portuondo DL, Batista-Duharte A, Carlos IZ (2025) Dendritic cell-based therapeutic immunization induces Th1\/Th17 responses and reduces fungal burden in experimental Sporotrichosis. Microorganisms 13(10):2351. https:\/\/doi.org\/10.3390\/microorganisms13102351","journal-title":"Microorganisms"},{"issue":"1","key":"4893_CR119","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12348-016-0111-2.","volume":"6","author":"AR Fox","year":"2016","unstructured":"Fox AR, Houser KH, Morris WR, Walton RC (2016) Dematiaceous fungal endophthalmitis: report of a case and review of the literature. J Ophthalmic Inflamm Infect 6(1):43. Epub 2016 Nov 8. PMID: 27822745; PMCID: PMC5099294 https:\/\/doi.org\/10.1186\/s12348-016-0111-2","journal-title":"J Ophthalmic Inflamm Infect"},{"issue":"2","key":"4893_CR120","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/jcm14020430","volume":"14","author":"P Toumasis","year":"2025","unstructured":"Toumasis P, Vrioni G, Gardeli I, Michelaki A, Exindari M, Orfanidou M (2025) Macrophomina phaseolina: A Phytopathogen Associated with Human Ocular Infections-A Case Report of Endophthalmitis and Systematic Review of Human Infections. J Clin Med 14(2):430. PMID: 39860436; PMCID: PMC11765806 https:\/\/doi.org\/10.3390\/jcm14020430","journal-title":"J Clin Med"},{"issue":"1","key":"4893_CR121","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3390\/jcm13010286","volume":"13","author":"P Toumasis","year":"2024","unstructured":"Toumasis P, Tsantes AG, Tsiogka A, Samonis G, Vrioni G (2024) From Clinical Suspicion to Diagnosis: A Review of Diagnostic Approaches and Challenges in Fungal Keratitis. J Clin Med 13(1):286. PMID: 38202293; PMCID: PMC10779560 https:\/\/doi.org\/10.3390\/jcm13010286","journal-title":"J Clin Med"},{"key":"4893_CR122","doi-asserted-by":"publisher","unstructured":"Prajna NV, Srinivasan M, Lalitha P, Krishnan T, Rajaraman R, Ravindran M, Mascarenhas J, Oldenburg CE, Ray KJ, McLeod SD, Acharya NR, Lietman TM (2013) Differences in clinical outcomes in keratitis due to fungus and bacteria. JAMA Ophthalmol 131(8):1088\u20131089. PMID: 23929517; PMCID: PMC3845453 https:\/\/doi.org\/10.1001\/jamaophthalmol.2013.1612","DOI":"10.1001\/jamaophthalmol.2013.1612"},{"key":"4893_CR123","doi-asserted-by":"publisher","unstructured":"Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A (2022) COVID-19-associated fungal infections. Nat Microbiol 7(8):1127\u20131140. Epub 2022 Aug 2. PMID: 35918423; PMCID: PMC9362108 https:\/\/doi.org\/10.1038\/s41564-022-01172-2","DOI":"10.1038\/s41564-022-01172-2"},{"key":"4893_CR124","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fimmu.2012.00338.","volume":"3","author":"JV Forrester","year":"2012","unstructured":"Forrester JV, Xu H (2012) Good news-bad news: the Yin and Yang of immune privilege in the eye. Front Immunol 3:338. PMID: 23230433; PMCID: PMC3515883 https:\/\/doi.org\/10.3389\/fimmu.2012.00338","journal-title":"Front Immunol"},{"key":"4893_CR125","doi-asserted-by":"publisher","unstructured":"Calich VL, da Costa TA, Felonato M, Arruda C, Bernardino S, Loures FV, Ribeiro LR C\u00e1ssia Valente-Ferreira R, Pina A. Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia. 2008 Apr-May;165(4-5):223-36. . PMID: 18777631 https:\/\/doi.org\/10.1007\/s11046-007-9048-1","DOI":"10.1007\/s11046-007-9048-1"},{"key":"4893_CR126","doi-asserted-by":"publisher","unstructured":"Romani L (2008) Cell mediated immunity to fungi: a reassessment. Med Mycol. ;46(6):515-29. . PMID: 19180748 https:\/\/doi.org\/10.1080\/13693780801971450","DOI":"10.1080\/13693780801971450"},{"key":"4893_CR127","doi-asserted-by":"publisher","unstructured":"Zhang SX (2013) Enhancing molecular approaches for diagnosis of fungal infections. Future Microbiol. ;8(12):1599-611. . PMID: 24266359 https:\/\/doi.org\/10.2217\/fmb.13.120","DOI":"10.2217\/fmb.13.120"},{"key":"4893_CR128","doi-asserted-by":"publisher","unstructured":"Grigor'eva AE, Tamkovich SN, Eremina AV, Tupikin AE, Kabilov MR, Chernykh VV, Vlassov VV, Laktionov PP, Ryabchikova EI [Characteristics of exosomes and microparticles discovered in human tears]. Biomed Khim. 2016 Jan-Feb;62(1):99 106. Russian. . PMID: 26973197 https:\/\/doi.org\/10.18097\/PBMC20166201099","DOI":"10.18097\/PBMC20166201099"},{"key":"4893_CR129","doi-asserted-by":"publisher","unstructured":"Ciferri MC, Quarto R, Tasso R (2021) Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications. Biology (Basel) 10(5):359. PMID: 33922446; PMCID: PMC8145169 https:\/\/doi.org\/10.3390\/biology10050359","DOI":"10.3390\/biology10050359"},{"key":"4893_CR130","doi-asserted-by":"publisher","unstructured":"Liu J, Hu X. Fungal extracellular vesicle-mediated regulation: from virulence factor to clinical application. Front Microbiol. 2023;14:1205477. Published 2023 Sep 15. doi:10.3389\/fmicb.2023.1205477 https:\/\/doi.org\/10.3389\/fmicb.2023.1205477","DOI":"10.3389\/fmicb.2023.1205477"},{"key":"4893_CR131","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.03.631181","author":"GN Kwaku","year":"2025","unstructured":"Kwaku GN, Jensen KN, Simaku P, et al. Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation. https:\/\/doi.org\/10.1101\/2025.01.03.631181","journal-title":"Preprint bioRxiv"},{"issue":"2","key":"4893_CR132","doi-asserted-by":"publisher","first-page":"836","DOI":"10.3390\/ijms26020836","volume":"26","author":"V Khristov","year":"2025","unstructured":"Khristov V, Weber SR, Caton-Darby M, Campbell G, Sundstrom JM (2025) Diagnostic and Therapeutic Utility of Extracellular Vesicles in Ocular Disease. Int J Mol Sci 26(2):836. PMID: 39859553; PMCID: PMC11765869 https:\/\/doi.org\/10.3390\/ijms26020836","journal-title":"Int J Mol Sci"},{"key":"4893_CR133","doi-asserted-by":"publisher","unstructured":"Gandhi J, Joseph J (2023) Aquaporin 5-in Extracellular Vesicles of Human Vitreous as a Potential Marker for Fungal Endophthalmitis. Curr Eye Res. ;48(8):750 757. . Epub 2023 Apr 20. PMID: 37027237 https:\/\/doi.org\/10.1080\/02713683.2023.2200912","DOI":"10.1080\/02713683.2023.2200912"},{"issue":"1","key":"4893_CR134","first-page":"13","volume":"17","author":"J Zhang","year":"2018","unstructured":"Zhang J, Bai C (2018) The Significance of Serum Interleukin-8 in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Tanaffos 17(1):13\u201321 PMID: 30116274; PMCID: PMC6087525","journal-title":"Tanaffos"},{"key":"4893_CR135","doi-asserted-by":"publisher","unstructured":"Santacruz C, Linares M, Garfias Y, Loustaunau LM, Pavon L, Perez-Tapia SM, Jimenez-Martinez MC (2015) Expression of IL-8, IL-6 and IL-1\u03b2 in tears as a main characteristic of the immune response in human microbial keratitis. Int J Mol Sci 16(3):4850\u20134864. PMID: 25741769; PMCID: PMC4394453 https:\/\/doi.org\/10.3390\/ijms16034850","DOI":"10.3390\/ijms16034850"},{"issue":"10","key":"4893_CR136","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1038\/eye.2008.382.","volume":"23","author":"AW Taylor","year":"2009","unstructured":"Taylor AW (2009) Ocular immune privilege. Eye (Lond) 23(10):1885\u20131889. Epub 2009 Jan 9. PMID: 19136922; PMCID: PMC4698145 https:\/\/doi.org\/10.1038\/eye.2008.382","journal-title":"Eye (Lond)"},{"key":"4893_CR137","doi-asserted-by":"publisher","unstructured":"Fang L, Liu J, Liu Z, Zhou H (2022) Immune modulating nanoparticles for the treatment of ocular diseases. J Nanobiotechnol 20(1):496. PMID: 36424630; PMCID: PMC9694601 https:\/\/doi.org\/10.1186\/s12951-022-01658-5","DOI":"10.1186\/s12951-022-01658-5"},{"issue":"4","key":"4893_CR138","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1128\/CMR.10.4.611","volume":"10","author":"L Romani","year":"1997","unstructured":"Romani L, Puccetti P, Bistoni F (1997) Interleukin-12 in infectious diseases. Clin Microbiol Rev 10(4):611\u2013636. PMID: 9336665; PMCID: PMC172937 https:\/\/doi.org\/10.1128\/CMR.10.4.611","journal-title":"Clin Microbiol Rev"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04893-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-04893-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04893-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:56:36Z","timestamp":1781690196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-026-04893-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,3]]},"references-count":138,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4893"],"URL":"https:\/\/doi.org\/10.1007\/s00284-026-04893-3","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,3]]},"assertion":[{"value":"1 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"347"}}