{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:51:48Z","timestamp":1781693508059,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002531","name":"Kyungpook National University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002531","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00284-026-04920-3","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:59:13Z","timestamp":1777053553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS-Mediated Apoptosis-Like Death Induced by Genistein in Candida albicans"],"prefix":"10.1007","volume":"83","author":[{"given":"Min Seok","family":"Kwun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Gun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"2","key":"4920_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/antibiotics9020045","volume":"9","author":"MS Al Aboody","year":"2020","unstructured":"Al Aboody MS, Mickymaray S (2020) Anti-fungal efficacy and mechanisms of flavonoids. Antibiotics 9(2):45. https:\/\/doi.org\/10.3390\/antibiotics9020045","journal-title":"Antibiotics"},{"issue":"8","key":"4920_CR2","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.3390\/molecules29081712","volume":"29","author":"M Liccardo","year":"2024","unstructured":"Liccardo M et al (2024) Genistein prevents apoptosis and oxidative stress induced by methylglyoxal in endothelial cells. Molecules 29(8):1712. https:\/\/doi.org\/10.3390\/molecules29081712","journal-title":"Molecules"},{"issue":"1","key":"4920_CR3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/plants14010120","volume":"14","author":"F Li","year":"2025","unstructured":"Li F et al (2025) Antifungal activity of genistein against phytopathogenic fungi Valsa mali through ROS-mediated lipid peroxidation. Plants 14(1):120. https:\/\/doi.org\/10.3390\/plants14010120","journal-title":"Plants"},{"key":"4920_CR4","doi-asserted-by":"publisher","unstructured":"Zhang L et al (2025) Genistein: A promising botanical fungicide candidate for enhancing tomato yield and quality by controlling Alternaria solani. Pestic Biochem Physiol 106588. https:\/\/doi.org\/10.1016\/j.pestbp.2025.106588","DOI":"10.1016\/j.pestbp.2025.106588"},{"issue":"2","key":"4920_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jof7020079","volume":"7","author":"J Talapko","year":"2021","unstructured":"Talapko J et al (2021) Candida albicans\u2014the virulence factors and clinical manifestations of infection. J fungi 7(2):79. https:\/\/doi.org\/10.3390\/jof7020079","journal-title":"J fungi"},{"key":"4920_CR6","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.3389\/fmicb.2016.02173","volume":"7","author":"SG Whaley","year":"2017","unstructured":"Whaley SG et al (2017) Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species. Front Microbiol 7:2173. https:\/\/doi.org\/10.3389\/fmicb.2016.02173","journal-title":"Front Microbiol"},{"key":"4920_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fonc.2012.00097","volume":"2","author":"N Shlezinger","year":"2012","unstructured":"Shlezinger N, Goldfinger N, Sharon A (2012) Apoptotic-like programed cell death in fungi: the benefits in filamentous species. Front Oncol 2:97. https:\/\/doi.org\/10.3389\/fonc.2012.00097","journal-title":"Front Oncol"},{"issue":"5","key":"4920_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/cdd.2009.219","volume":"17","author":"D Carmona-Gutierrez","year":"2010","unstructured":"Carmona-Gutierrez D et al (2010) Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ 17(5):763\u2013773. https:\/\/doi.org\/10.1038\/cdd.2009.219","journal-title":"Cell Death Differ"},{"issue":"1\u20132","key":"4920_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mrfmmm.2003.08.019","volume":"532","author":"WC Burhans","year":"2003","unstructured":"Burhans WC et al (2003) Apoptosis-like yeast cell death in response to DNA damage and replication defects. Mutat Research\/Fundamental Mol Mech Mutagen 532(1\u20132):227\u2013243. https:\/\/doi.org\/10.1016\/j.mrfmmm.2003.08.019","journal-title":"Mutat Research\/Fundamental Mol Mech Mutagen"},{"key":"4920_CR10","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fcimb.2018.00445","volume":"8","author":"C Jia","year":"2019","unstructured":"Jia C et al (2019) Antifungal activity of coumarin against Candida albicans is related to apoptosis. Front Cell Infect Microbiol 8:445. https:\/\/doi.org\/10.3389\/fcimb.2018.00445","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"4920_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/jof10020090","volume":"10","author":"A-L Bienvenu","year":"2024","unstructured":"Bienvenu A-L, Ballut L, Picot S (2024) Specifically targeting metacaspases of Candida: a new therapeutic opportunity. J Fungi 10(2):90. https:\/\/doi.org\/10.3390\/jof10020090","journal-title":"J Fungi"},{"issue":"6","key":"4920_CR12","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.3390\/ijms24065445","volume":"24","author":"W Ye","year":"2023","unstructured":"Ye W et al (2023) Potential anti-Candida albicans mechanism of Trichoderma acid from Trichoderma spirale. Int J Mol Sci 24(6):5445. https:\/\/doi.org\/10.3390\/ijms24065445","journal-title":"Int J Mol Sci"},{"issue":"15","key":"4920_CR13","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1016\/j.febslet.2009.07.004","volume":"583","author":"AM Aerts","year":"2009","unstructured":"Aerts AM et al (2009) The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans. FEBS Lett 583(15):2513\u20132516. https:\/\/doi.org\/10.1016\/j.febslet.2009.07.004","journal-title":"FEBS Lett"},{"issue":"7","key":"4920_CR14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21(7):363\u2013383. https:\/\/doi.org\/10.1038\/s41580-020-0230-3","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4920_CR15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.fct.2014.02.004","volume":"67","author":"W Chen","year":"2014","unstructured":"Chen W et al (2014) High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species. Food Chem Toxicol 67:72\u201379. https:\/\/doi.org\/10.1016\/j.fct.2014.02.004","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"4920_CR16","doi-asserted-by":"publisher","first-page":"e86032","DOI":"10.1371\/journal.pone.0086032","volume":"8","author":"PW-K Tsang","year":"2013","unstructured":"Tsang PW-K et al (2013) Purpurin triggers caspase-independent apoptosis in Candida dubliniensis biofilms. PLoS ONE 8(12):e86032. https:\/\/doi.org\/10.1371\/journal.pone.0086032","journal-title":"PLoS ONE"},{"key":"4920_CR17","doi-asserted-by":"publisher","unstructured":"Ramsdale M (2006) Programmed cell death and apoptosis in fungi. Fungal genomics. Springer, pp 113\u2013146. https:\/\/doi.org\/10.1007\/3-540-30809-1","DOI":"10.1007\/3-540-30809-1"},{"issue":"3","key":"4920_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.tcb.2020.11.005","volume":"31","author":"G Camilli","year":"2021","unstructured":"Camilli G et al (2021) Programmed cell death: central player in fungal infections. Trends Cell Biol 31(3):179\u2013196. https:\/\/doi.org\/10.1016\/j.tcb.2020.11.005","journal-title":"Trends Cell Biol"},{"key":"4920_CR19","doi-asserted-by":"publisher","unstructured":"Averill-Bates DA (2023) The antioxidant glutathione. Vitamins and hormones. Elsevier, pp 109\u2013141. https:\/\/doi.org\/10.1016\/bs.vh.2022.09.002","DOI":"10.1016\/bs.vh.2022.09.002"},{"issue":"3","key":"4920_CR20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.119.3.493","volume":"119","author":"Y Gavrieli","year":"1992","unstructured":"Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119(3):493\u2013501. https:\/\/doi.org\/10.1083\/jcb.119.3.493","journal-title":"J Cell Biol"},{"key":"4920_CR21","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fphar.2014.00196","volume":"5","author":"K Aquilano","year":"2014","unstructured":"Aquilano K, Baldelli S, Ciriolo MR (2014) Glutathione: new roles in redox signaling for an old antioxidant. Front Pharmacol 5:196. https:\/\/doi.org\/10.3389\/fphar.2014.00196","journal-title":"Front Pharmacol"},{"issue":"3","key":"4920_CR22","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/S0008-6363(99)00384-3","volume":"45","author":"A Saraste","year":"2000","unstructured":"Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovascular Res 45(3):528\u2013537. https:\/\/doi.org\/10.1016\/S0008-6363(99)00384-3","journal-title":"Cardiovascular Res"},{"issue":"3","key":"4920_CR23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1742-4658.2010.07975.x","volume":"278","author":"I Kitazumi","year":"2011","unstructured":"Kitazumi I, Tsukahara M (2011) Regulation of DNA fragmentation: the role of caspases and phosphorylation. FEBS J 278(3):427\u2013441. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07975.x","journal-title":"FEBS J"},{"key":"4920_CR24","doi-asserted-by":"publisher","first-page":"970688","DOI":"10.3389\/fcimb.2022.970688","volume":"12","author":"S Sasidharan","year":"2022","unstructured":"Sasidharan S, Nishanth KS, Nair HJ (2022) Ethanolic extract of Caesalpinia bonduc seeds triggers yeast metacaspase-dependent apoptotic pathway mediated by mitochondrial dysfunction through enhanced production of calcium and reactive oxygen species (ROS) in Candida albicans. Front Cell Infect Microbiol 12:970688. https:\/\/doi.org\/10.3389\/fcimb.2022.970688","journal-title":"Front Cell Infect Microbiol"},{"issue":"1\u20132","key":"4920_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-5793(00)01707-5","volume":"477","author":"VE Kagan","year":"2000","unstructured":"Kagan VE et al (2000) Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis. FEBS Lett 477(1\u20132):1\u20137. https:\/\/doi.org\/10.1016\/S0014-5793(00)01707-5","journal-title":"FEBS Lett"},{"issue":"6","key":"4920_CR26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1080\/10715760701297354","volume":"41","author":"HM Peshavariya","year":"2007","unstructured":"Peshavariya HM, Dusting GJ, Selemidis S (2007) Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase. Free Radic Res 41(6):699\u2013712. https:\/\/doi.org\/10.1080\/10715760701297354","journal-title":"Free Radic Res"},{"issue":"1","key":"4920_CR27","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1128\/aac.01366-12","volume":"57","author":"B Hao","year":"2013","unstructured":"Hao B et al (2013) Caspofungin kills Candida albicans by causing both cellular apoptosis and necrosis. Antimicrob Agents Chemother 57(1):326\u2013332. https:\/\/doi.org\/10.1128\/aac.01366-12","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04920-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-04920-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-04920-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:57:19Z","timestamp":1781690239000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-026-04920-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4920"],"URL":"https:\/\/doi.org\/10.1007\/s00284-026-04920-3","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"23 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"332"}}