{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:01:41Z","timestamp":1790096501125,"version":"4.0.1"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["No. 2024A1515012892"],"award-info":[{"award-number":["No. 2024A1515012892"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00284-026-05071-1","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:34:49Z","timestamp":1785155689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of the Oral Microbiome in the Development and Treatment of Periodontal Disease: Functional Meta-Omics Evidence"],"prefix":"10.1007","volume":"83","author":[{"given":"Xiling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"11","key":"5071_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Bernab\u00e9 E, Dahiya M, Bhandari B, Murray CJL, Marcenes W (2014) Global Burden of Severe Periodontitis in 1990\u20132010: A Systematic Review and Meta-regression. J Dent Res 93(11):1045\u20131053. https:\/\/doi.org\/10.1177\/0022034514552491","journal-title":"J Dent Res"},{"issue":"5","key":"5071_CR2","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/jcpe.13769","volume":"50","author":"D Trindade","year":"2023","unstructured":"Trindade D, Carvalho R, Machado V, Chambrone L, Mendes JJ, Botelho J (2023) Prevalence of periodontitis in dentate people between 2011 and 2020: a systematic review and meta-analysis of epidemiological studies. J Clin Periodontol 50(5):604\u2013626. https:\/\/doi.org\/10.1111\/jcpe.13769","journal-title":"J Clin Periodontol"},{"issue":"1","key":"5071_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/srep38993","volume":"6","author":"SM Dabdoub","year":"2016","unstructured":"Dabdoub SM, Ganesan SM, Kumar PS (2016) Comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis. Sci Rep 6(1):38993. https:\/\/doi.org\/10.1038\/srep38993","journal-title":"Sci Rep"},{"issue":"1","key":"5071_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","volume":"86","author":"L Abusleme","year":"2021","unstructured":"Abusleme L, Hoare A, Hong B, Diaz PI (2021) Microbial signatures of health, gingivitis, and periodontitis. Periodontology 2000 86(1):57\u201378. https:\/\/doi.org\/10.1111\/prd.12362","journal-title":"Periodontology 2000"},{"issue":"1","key":"5071_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-311","volume":"15","author":"A Ben\u00edtez-P\u00e1ez","year":"2014","unstructured":"Ben\u00edtez-P\u00e1ez A, Belda-Ferre P, Sim\u00f3n-Soro A, Mira A (2014) Microbiota diversity and gene expression dynamics in human oral biofilms. BMC Genomics 15(1):311. https:\/\/doi.org\/10.1186\/1471-2164-15-311","journal-title":"BMC Genomics"},{"key":"5071_CR6","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3389\/fgene.2019.00904","volume":"10","author":"M Shakya","year":"2019","unstructured":"Shakya M, Lo C-C, Chain PSG (2019) Advances and Challenges in Metatranscriptomic Analysis. Front Genet 10:904. https:\/\/doi.org\/10.3389\/fgene.2019.00904","journal-title":"Front Genet"},{"issue":"1","key":"5071_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0153-3","volume":"7","author":"S Yost","year":"2015","unstructured":"Yost S, Duran-Pinedo AE, Teles R, Krishnan K, Frias-Lopez J (2015) Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. Genome Med 7(1):27. https:\/\/doi.org\/10.1186\/s13073-015-0153-3","journal-title":"Genome Med"},{"key":"5071_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.728585","volume":"12","author":"Y Huang","year":"2021","unstructured":"Huang Y, Zhao X, Cui L, Huang S (2021) Metagenomic and metatranscriptomic insight into oral biofilms in periodontitis and related systemic diseases. Front Microbiol 12:728585. https:\/\/doi.org\/10.3389\/fmicb.2021.728585","journal-title":"Front Microbiol"},{"issue":"2","key":"5071_CR9","doi-asserted-by":"publisher","first-page":"e00575","DOI":"10.1128\/mBio.00575-18","volume":"9","author":"EM Nowicki","year":"2018","unstructured":"Nowicki EM, Shroff R, Singleton JA, Renaud DE, Wallace D, Drury J, Zirnheld J, Colleti B, Ellington AD, Lamont RJ, Scott DA, Whiteley M (2018) Microbiota and Metatranscriptome Changes Accompanying the Onset of Gingivitis. mBio 9(2):e00575\u2013e00518. https:\/\/doi.org\/10.1128\/mBio.00575-18","journal-title":"mBio"},{"issue":"10","key":"5071_CR10","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1128\/JB.00028-10","volume":"192","author":"JK Kajfasz","year":"2010","unstructured":"Kajfasz JK, Rivera-Ramos I, Abranches J, Martinez AR, Rosalen PL, Derr AM, Quivey RG, Lemos JA (2010) Two Spx Proteins Modulate Stress Tolerance, Survival, and Virulence in Streptococcus mutans. J Bacteriol 192(10):2546\u20132556. https:\/\/doi.org\/10.1128\/JB.00028-10","journal-title":"J Bacteriol"},{"issue":"2","key":"5071_CR11","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1365-2958.2004.04395.x","volume":"55","author":"S Nakano","year":"2005","unstructured":"Nakano S, Erwin KN, Ralle M, Zuber P (2005) Redox-sensitive transcriptional control by a thiol\/disulphide switch in the global regulator, Spx. Mol Microbiol 55(2):498\u2013510. https:\/\/doi.org\/10.1111\/j.1365-2958.2004.04395.x","journal-title":"Mol Microbiol"},{"issue":"1","key":"5071_CR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/prd.12296","volume":"83","author":"MA Curtis","year":"2020","unstructured":"Curtis MA, Diaz PI, Van Dyke TE (2020) The role of the microbiota in periodontal disease. Periodontology 2000 83(1):14\u201325. https:\/\/doi.org\/10.1111\/prd.12296","journal-title":"Periodontology 2000"},{"issue":"5171","key":"5071_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1126\/science.7545940","volume":"265","author":"GW Huisman","year":"1994","unstructured":"Huisman GW, Kolter R (1994) Sensing Starvation: a Homoserine Lactone\u2014Dependent Signaling Pathway in Escherichia coli. Science 265(5171):537\u2013539. https:\/\/doi.org\/10.1126\/science.7545940","journal-title":"Science"},{"issue":"1\u20132","key":"5071_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.vetmic.2015.01.027","volume":"179","author":"T Okoko","year":"2015","unstructured":"Okoko T, Blagova EV, Whittingham JL, Dover LG, Wilkinson AJ (2015) Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi. Vet Microbiol 179(1\u20132):42\u201352. https:\/\/doi.org\/10.1016\/j.vetmic.2015.01.027","journal-title":"Vet Microbiol"},{"issue":"7","key":"5071_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ijmm.2015.08.018","volume":"305","author":"P Vielkind","year":"2015","unstructured":"Vielkind P, Jentsch H, Eschrich K, Rodloff AC, Stingu C-S (2015) Prevalence of Actinomyces spp. in patients with chronic periodontitis. Int J Med Microbiol 305(7):682\u2013688. https:\/\/doi.org\/10.1016\/j.ijmm.2015.08.018","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"5071_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12958","volume":"21","author":"K von Bargen","year":"2019","unstructured":"von Bargen K, Scraba M, Kr\u00e4mer I, Ketterer M, Nehls C, Krokowski S, Repnik U, Wittlich M, Maaser A, Zapka P, Bunge M, Schlesinger M, Huth G, Klees A, Hansen P, Jeschke A, Bendas G, Uterm\u00f6hlen O, Griffiths G, Gutsmann T, Wohlmann J, Haas A (2019) Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH\u2010neutralising virulence factor. Cell Microbiol 21(1):e12958. https:\/\/doi.org\/10.1111\/cmi.12958","journal-title":"Cell Microbiol"},{"issue":"8","key":"5071_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072354","volume":"8","author":"MW Julian","year":"2013","unstructured":"Julian MW, Shao G, VanGundy ZC, Papenfuss TL, Crouser ED (2013) Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF\u03b1 release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. PLoS ONE 8(8):e72354. https:\/\/doi.org\/10.1371\/journal.pone.0072354","journal-title":"PLoS ONE"},{"issue":"7","key":"5071_CR18","doi-asserted-by":"publisher","first-page":"e52891","DOI":"10.15252\/embr.202152891","volume":"22","author":"Q Meng","year":"2021","unstructured":"Meng Q, Gao Q, Mehrazarin S, Tangwanichgapong K, Wang Y, Huang Y, Pan Y, Robinson S, Liu Z, Zangiabadi A, Lux R, Papapanou PN, Guo XE, Wang H, Berchowitz LE, Han YW (2021) Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity. EMBO Rep 22(7):e52891. https:\/\/doi.org\/10.15252\/embr.202152891","journal-title":"EMBO Rep"},{"issue":"1","key":"5071_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085280","volume":"9","author":"P Liu","year":"2014","unstructured":"Liu P, Liu Y, Wang J, Guo Y, Zhang Y, Xiao S (2014) Detection of Fusobacterium nucleatum and fadA adhesin gene in patients with orthodontic gingivitis and non-orthodontic periodontal inflammation. PLoS ONE 9(1):e85280. https:\/\/doi.org\/10.1371\/journal.pone.0085280","journal-title":"PLoS ONE"},{"key":"5071_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.815318","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen Y, Huang Z, Tang Z, Huang Y, Huang M, Liu H, Ziebolz D, Schmalz G, Jia B, Zhao J (2022) More than just a periodontal pathogen \u2013the research progress on Fusobacterium nucleatum. Front Cell Infect Microbiol 12:815318. https:\/\/doi.org\/10.3389\/fcimb.2022.815318","journal-title":"Front Cell Infect Microbiol"},{"issue":"34","key":"5071_CR21","doi-asserted-by":"publisher","first-page":"25000","DOI":"10.1074\/jbc.M611567200","volume":"282","author":"M Xu","year":"2007","unstructured":"Xu M, Yamada M, Li M, Liu H, Chen SG, Han YW (2007) FadA from Fusobacterium nucleatum Utilizes both Secreted and Nonsecreted Forms for Functional Oligomerization for Attachment and Invasion of Host Cells. J Biol Chem 282(34):25000\u201325009. https:\/\/doi.org\/10.1074\/jbc.M611567200","journal-title":"J Biol Chem"},{"issue":"2","key":"5071_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1177\/0022034513516346","volume":"93","author":"P Lee","year":"2014","unstructured":"Lee P, Tan KS (2014) Fusobacterium nucleatum activates the immune response through retinoic acid\u2013inducible gene I. J Dent Res 93(2):162\u2013168. https:\/\/doi.org\/10.1177\/0022034513516346","journal-title":"J Dent Res"},{"issue":"1","key":"5071_CR23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41368-022-00213-0","volume":"15","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wang L, Sun T, Shen S, Li Z, Ma X, Gu X, Zhang X, Peng A, Xu X, Feng Q (2023) Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs. Int J Oral Sci 15(1):8. https:\/\/doi.org\/10.1038\/s41368-022-00213-0","journal-title":"Int J Oral Sci"},{"issue":"10","key":"5071_CR24","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/embor.2010.114","volume":"11","author":"B Hoy","year":"2010","unstructured":"Hoy B, L\u00f6wer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schr\u00f6der P, Sewald N, Backert S, Schneider G, Wessler S (2010) Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep 11(10):798\u2013804. https:\/\/doi.org\/10.1038\/embor.2010.114","journal-title":"EMBO Rep"},{"issue":"6","key":"5071_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12845","volume":"20","author":"S Backert","year":"2018","unstructured":"Backert S, Bernegger S, Sk\u00f3rko-Glonek J, Wessler S (2018) Extracellular HtrA serine proteases: an emerging new strategy in bacterial pathogenesis. Cell Microbiol 20(6):e12845. https:\/\/doi.org\/10.1111\/cmi.12845","journal-title":"Cell Microbiol"},{"issue":"2","key":"5071_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/mmi.12377","volume":"90","author":"TM Russell","year":"2013","unstructured":"Russell TM, Delorey MJ, Johnson BJB (2013) B orrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro. Mol Microbiol 90(2):241\u2013251. https:\/\/doi.org\/10.1111\/mmi.12377","journal-title":"Mol Microbiol"},{"issue":"1","key":"5071_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/odi.12128","volume":"20","author":"I Binderman","year":"2014","unstructured":"Binderman I, Gadban N, Yaffe A (2014) Cytoskeletal disease: a role in the etiology of adult periodontitis. Oral Dis 20(1):10\u201316. https:\/\/doi.org\/10.1111\/odi.12128","journal-title":"Oral Dis"},{"key":"5071_CR28","doi-asserted-by":"publisher","DOI":"10.4172\/2376-032X.1000162","author":"NG Evgeny Weinberg","year":"2015","unstructured":"Evgeny Weinberg NG (2015) Strain Reduction of Human Gingival Fibroblasts Induces the ATP Pathway. J Interdiscipl Med Dent Sci. https:\/\/doi.org\/10.4172\/2376-032X.1000162","journal-title":"J Interdiscipl Med Dent Sci"},{"key":"5071_CR29","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.archoralbio.2017.05.002","volume":"81","author":"I Binderman","year":"2017","unstructured":"Binderman I, Gadban N, Yaffe A (2017) Extracellular ATP is a key modulator of alveolar bone loss in periodontitis. Arch Oral Biol 81:131\u2013135. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.05.002","journal-title":"Arch Oral Biol"},{"issue":"12","key":"5071_CR30","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.1182\/blood-2005-07-2994","volume":"107","author":"BJ Gu","year":"2006","unstructured":"Gu BJ, Wiley JS (2006) Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Blood 107(12):4946\u20134953. https:\/\/doi.org\/10.1182\/blood-2005-07-2994","journal-title":"Blood"},{"key":"5071_CR31","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1100\/2011\/212680","volume":"11","author":"M Sahoo","year":"2011","unstructured":"Sahoo M, Ceballos-Olvera I, Del Barrio L, Re F (2011) Role of the inflammasome, IL-1\u03b2, and IL-18 in bacterial infections. ScientificWorldJournal 11:2037\u20132050. https:\/\/doi.org\/10.1100\/2011\/212680","journal-title":"ScientificWorldJournal"},{"key":"5071_CR32","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3389\/fmicb.2020.00482","volume":"11","author":"N Ram-Mohan","year":"2020","unstructured":"Ram-Mohan N, Meyer MM (2020) Comparative Metatranscriptomics of Periodontitis Supports a Common Polymicrobial Shift in Metabolic Function and Identifies Novel Putative Disease-Associated ncRNAs. Front Microbiol 11:482. https:\/\/doi.org\/10.3389\/fmicb.2020.00482","journal-title":"Front Microbiol"},{"issue":"4","key":"5071_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.anaerobe.2010.04.005","volume":"16","author":"L Miao","year":"2010","unstructured":"Miao L, Liu Y, Li Q, Wang Z, Li H, Zhang G (2010) Screening and sequence analysis of the hemolysin gene of Fusobacterium necrophorum. Anaerobe 16(4):402\u2013404. https:\/\/doi.org\/10.1016\/j.anaerobe.2010.04.005","journal-title":"Anaerobe"},{"key":"5071_CR34","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/B978-0-12-801122-5.00020-9","volume":"549","author":"MF Schaffer","year":"2014","unstructured":"Schaffer MF, Choudhary PK, Sigel RKO (2014) The AdoCbl\u2013Riboswitch Interaction Investigated by In-Line Probing and Surface Plasmon Resonance Spectroscopy (SPR). Methods Enzymol 549:467\u2013488. https:\/\/doi.org\/10.1016\/B978-0-12-801122-5.00020-9","journal-title":"Methods Enzymol"},{"issue":"1","key":"5071_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13892","volume":"8","author":"A Chauvier","year":"2017","unstructured":"Chauvier A, Picard-Jean F, Berger-Dancause JC, Bastet L, Naghdi MR, Dub\u00e9 A, Turcotte P, Perreault J, Lafontaine DA (2017) Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation. Nat Commun 8(1):13892. https:\/\/doi.org\/10.1038\/ncomms13892","journal-title":"Nat Commun"},{"issue":"1","key":"5071_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/npjbiofilms.2015.17","volume":"1","author":"SP Szafra\u0144ski","year":"2015","unstructured":"Szafra\u0144ski SP, Deng ZL, Tomasch J, Jarek M, Bhuju S, Meisinger C, K\u00fchnisch J, Sztajer H, Wagner-D\u00f6bler I (2015) Functional biomarkers for chronic periodontitis and insights into the roles of Prevotella nigrescens and Fusobacterium nucleatum; a metatranscriptome analysis. NPJ Biofilms Microbiomes 1(1):15017. https:\/\/doi.org\/10.1038\/npjbiofilms.2015.17","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"5","key":"5071_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000419","volume":"5","author":"H W\u00f3jtowicz","year":"2009","unstructured":"W\u00f3jtowicz H, Guevara T, Tallant C, Olczak M, Sroka A, Potempa J, Sol\u00e0 M, Olczak T, Gomis-R\u00fcth FX (2009) Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis. PLoS Pathog 5(5):e1000419. https:\/\/doi.org\/10.1371\/journal.ppat.1000419","journal-title":"PLoS Pathog"},{"issue":"1","key":"5071_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-134","volume":"10","author":"T Olczak","year":"2010","unstructured":"Olczak T, W\u00f3jtowicz H, Ciuraszkiewicz J, Olczak M (2010) Species specificity, surface exposure, protein expression, immunogenicity, and participation in biofilm formation of Porphyromonas gingivalis HmuY. BMC Microbiol 10(1):134. https:\/\/doi.org\/10.1186\/1471-2180-10-134","journal-title":"BMC Microbiol"},{"issue":"1","key":"5071_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/omi.12149","volume":"32","author":"JW Smalley","year":"2017","unstructured":"Smalley JW, Olczak T (2017) Heme acquisition mechanisms of Porphyromonas gingivalis \u2013 strategies used in a polymicrobial community in a heme-limited host environment. Mol Oral Microbiol 32(1):1\u201323. https:\/\/doi.org\/10.1111\/omi.12149","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"5071_CR40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-0765.2011.01401.x","volume":"47","author":"SC Trindade","year":"2012","unstructured":"Trindade SC, Olczak T, Gomes-Filho IS, Moura-Costa LF, Cerqueira EM, Galdino-Neto M, Alves H, Carvalho-Filho PC, Xavier MT, Meyer R (2012) Induction of interleukin (IL)-1\u03b2, IL\u201010, IL\u20108 and immunoglobulin G by Porphyromonas gingivalis HmuY in humans. J Periodontal Res 47(1):27\u201332. https:\/\/doi.org\/10.1111\/j.1600-0765.2011.01401.x","journal-title":"J Periodontal Res"},{"issue":"11","key":"5071_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114150","volume":"21","author":"P \u015al\u0119zak","year":"2020","unstructured":"\u015al\u0119zak P, \u015amiga M, Smalley JW, Siemi\u0144ska K, Olczak T (2020) Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH\u2014novel heme acquisition strategy in the oral microbiome. Int J Mol Sci 21(11):4150. https:\/\/doi.org\/10.3390\/ijms21114150","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5071_CR42","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1399-302X.2009.00538.x","volume":"24","author":"MT Baer","year":"2009","unstructured":"Baer MT, Huang N, Iii FCG (2009) Scavenger receptor A is expressed by macrophages in response to Porphyromonas gingivalis, and participates in TNF-alpha expression. Oral Microbiol Immunol 24(6):456\u2013463. https:\/\/doi.org\/10.1111\/j.1399-302X.2009.00538.x","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"5071_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100813","volume":"18","author":"R Zhang","year":"2023","unstructured":"Zhang R, Luo S, Zhao T, Wu M, Huang L, Zhang L, Huang Y, Gao H, Sun X, Gong T, Zhang Z (2023) Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury. Asian J Pharm Sci 18(3):100813. https:\/\/doi.org\/10.1016\/j.ajps.2023.100813","journal-title":"Asian J Pharm Sci"},{"key":"5071_CR44","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.anaerobe.2017.10.005","volume":"48","author":"K Okamoto-Shibayama","year":"2017","unstructured":"Okamoto-Shibayama K, Sekino J, Yoshikawa K, Saito A, Ishihara K (2017) Antimicrobial susceptibility profiles of oral Treponema species. Anaerobe 48:242\u2013248. https:\/\/doi.org\/10.1016\/j.anaerobe.2017.10.005","journal-title":"Anaerobe"},{"issue":"8","key":"5071_CR45","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.resmic.2019.06.001","volume":"170","author":"C Orelle","year":"2019","unstructured":"Orelle C, Mathieu K, Jault J-M (2019) Multidrug ABC transporters in bacteria. Res Microbiol 170(8):381\u2013391. https:\/\/doi.org\/10.1016\/j.resmic.2019.06.001","journal-title":"Res Microbiol"},{"issue":"1","key":"5071_CR46","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1021\/acs.chemrev.2c00431","volume":"123","author":"N Aggarwal","year":"2023","unstructured":"Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW (2023) Microbiome and human health: current understanding, engineering, and enabling technologies. Chem Rev 123(1):31\u201372. https:\/\/doi.org\/10.1021\/acs.chemrev.2c00431","journal-title":"Chem Rev"},{"issue":"1","key":"5071_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/prd.12107","volume":"70","author":"SP Barros","year":"2016","unstructured":"Barros SP, Williams R, Offenbacher S, Morelli T (2016) Gingival crevicular fluid as a source of biomarkers for periodontitis. Periodontology 2000 70(1):53\u201364. https:\/\/doi.org\/10.1111\/prd.12107","journal-title":"Periodontology 2000"},{"key":"5071_CR48","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12595","author":"N Buduneli","year":"2024","unstructured":"Buduneli N, B\u0131y\u0131ko\u011flu B, Kinane DF (2024) Utility of gingival crevicular fluid components for periodontal diagnosis. Periodontology 2000. https:\/\/doi.org\/10.1111\/prd.12595","journal-title":"Periodontology 2000"},{"issue":"20","key":"5071_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202000321","volume":"21","author":"X Xiao","year":"2021","unstructured":"Xiao X, Song T, Xiao X, Liu Y, Sun H, Guo Z, Liu X, Shao C, Li Q, Sun W (2021) A qualitative and quantitative analysis of the human gingival crevicular fluid proteome and metaproteome. Proteomics 21(20):2000321. https:\/\/doi.org\/10.1002\/pmic.202000321","journal-title":"Proteomics"},{"issue":"5","key":"5071_CR50","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1021\/pr900941z","volume":"9","author":"N Bostanci","year":"2010","unstructured":"Bostanci N, Heywood W, Mills K, Parkar M, Nibali L, Donos N (2010) Application of Label-Free Absolute Quantitative Proteomics in Human Gingival Crevicular Fluid by LC\/MS E (Gingival Exudatome). J Proteome Res 9(5):2191\u20132199. https:\/\/doi.org\/10.1021\/pr900941z","journal-title":"J Proteome Res"},{"issue":"8","key":"5071_CR51","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/jcpe.12262","volume":"41","author":"LG Carneiro","year":"2014","unstructured":"Carneiro LG, Nouh H, Salih E (2014) Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometry. J Clin Periodontol 41(8):733\u2013747. https:\/\/doi.org\/10.1111\/jcpe.12262","journal-title":"J Clin Periodontol"},{"issue":"1","key":"5071_CR52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1477-5956-9-42","volume":"9","author":"Y-J Choi","year":"2011","unstructured":"Choi Y-J, Heo S-H, Lee J-M, Cho J-Y (2011) Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid. Proteome Sci 9(1):42. https:\/\/doi.org\/10.1186\/1477-5956-9-42","journal-title":"Proteome Sci"},{"issue":"2","key":"5071_CR53","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1021\/pr300761e","volume":"12","author":"N Bostanci","year":"2013","unstructured":"Bostanci N, Ramberg P, Wahlander \u00c5, Grossman J, J\u00f6nsson D, Barnes VM, Papapanou PN (2013) Label-free quantitative proteomics reveals differentially regulated proteins in experimental gingivitis. J Proteome Res 12(2):657\u2013678. https:\/\/doi.org\/10.1021\/pr300761e","journal-title":"J Proteome Res"},{"issue":"9","key":"5071_CR54","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/ismej.2014.32","volume":"8","author":"S Huang","year":"2014","unstructured":"Huang S, Li R, Zeng X, He T, Zhao H, Chang A, Bo C, Chen J, Yang F, Knight R, Liu J, Davis C, Xu J (2014) Predictive modeling of gingivitis severity and susceptibility via oral microbiota. ISME J 8(9):1768\u20131780. https:\/\/doi.org\/10.1038\/ismej.2014.32","journal-title":"ISME J"},{"issue":"3","key":"5071_CR55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.tibs.2005.01.005","volume":"30","author":"J Kim","year":"2005","unstructured":"Kim J, Dang CV (2005) Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 30(3):142\u2013150. https:\/\/doi.org\/10.1016\/j.tibs.2005.01.005","journal-title":"Trends Biochem Sci"},{"key":"5071_CR56","doi-asserted-by":"publisher","first-page":"1275438","DOI":"10.3389\/fpls.2023.1275438","volume":"14","author":"L Heo","year":"2023","unstructured":"Heo L, Han Y, Cho Y, Choi J, Lee J, Han S-W (2023) A putative glucose 6-phosphate isomerase has pleiotropic functions on virulence and other mechanisms in Acidovorax citrulli. Front Plant Sci 14:1275438. https:\/\/doi.org\/10.3389\/fpls.2023.1275438","journal-title":"Front Plant Sci"},{"issue":"1063","key":"5071_CR57","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1098\/rstb.1981.0068","volume":"293","author":"A Achari","year":"1981","unstructured":"Achari A, Marshall SE, Muirhead H, Palmieri RH, Noltmann EA (1981) Glucose\u2009\u2013\u20096 - phosphate isomerase. Phil Trans R Soc Lond B 293(1063):145\u2013157. https:\/\/doi.org\/10.1098\/rstb.1981.0068","journal-title":"Phil Trans R Soc Lond B"},{"issue":"3","key":"5071_CR58","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00284-022-02778-9","volume":"79","author":"AS Letieri","year":"2022","unstructured":"Letieri AS, Freitas-Fernandes LB, Souza IPR, Valente AP, Fidalgo TKS (2022) Metabolomic Signatures of In Vitro Biofilm Maturation of Streptococcus mutans. Curr Microbiol 79(3):86. https:\/\/doi.org\/10.1007\/s00284-022-02778-9","journal-title":"Curr Microbiol"},{"issue":"12","key":"5071_CR59","first-page":"2667","volume":"58","author":"Y Niinaka","year":"1998","unstructured":"Niinaka Y, Paku S, Haga A, Watanabe H, Raz A (1998) Expression and secretion of neuroleukin\/phosphohexose isomerase\/maturation factor as autocrine motility factor by tumor cells. Cancer Res 58(12):2667\u20132674","journal-title":"Cancer Res"},{"issue":"5","key":"5071_CR60","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1006\/bbrc.2001.4912","volume":"284","author":"T Funasaka","year":"2001","unstructured":"Funasaka T, Haga A, Raz A, Nagase H (2001) Tumor Autocrine Motility Factor Is an Angiogenic Factor That Stimulates Endothelial Cell Motility. Biochem Biophysl Res Commun 284(5):1116\u20131125. https:\/\/doi.org\/10.1006\/bbrc.2001.4912","journal-title":"Biochem Biophysl Res Commun"},{"issue":"3","key":"5071_CR61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/ijc.10617","volume":"101","author":"T Funasaka","year":"2002","unstructured":"Funasaka T, Haga A, Raz A, Nagase H (2002) Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells. Int J Cancer 101(3):217\u2013223. https:\/\/doi.org\/10.1002\/ijc.10617","journal-title":"Int J Cancer"},{"issue":"1","key":"5071_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010085","volume":"11","author":"S Niklander","year":"2021","unstructured":"Niklander S, Bordagaray MJ, Fern\u00e1ndez A, Hern\u00e1ndez M (2021) Vascular endothelial growth factor: a translational view in oral non-communicable diseases. Biomolecules 11(1):85. https:\/\/doi.org\/10.3390\/biom11010085","journal-title":"Biomolecules"},{"issue":"2","key":"5071_CR63","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/genetics\/154.2.523","volume":"154","author":"IJ Mehr","year":"2000","unstructured":"Mehr IJ, Long CD, Serkin CD, Seifert HS (2000) A Homologue of the Recombination-Dependent Growth Gene, rdgC, Is Involved in Gonococcal Pilin Antigenic Variation. Genetics 154(2):523\u2013532. https:\/\/doi.org\/10.1093\/genetics\/154.2.523","journal-title":"Genetics"},{"issue":"Pt 11","key":"5071_CR64","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1099\/00221287-148-11-3539","volume":"148","author":"T Morimoto","year":"2002","unstructured":"Morimoto T, Loh PC, Hirai T, Asai K, Kobayashi K, Moriya S, Ogasawara N (2002) Six GTP-binding proteins of the Era\/Obg family are essential for cell growth in Bacillus subtilis. Microbiol (Reading) 148(Pt 11):3539\u20133552. https:\/\/doi.org\/10.1099\/00221287-148-11-3539","journal-title":"Microbiol (Reading)"},{"issue":"11","key":"5071_CR65","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1110\/ps.072900907","volume":"16","author":"HK Lamb","year":"2007","unstructured":"Lamb HK, Thompson P, Elliott C, Charles IG, Richards J, Lockyer M, Watkins N, Nichols C, Stammers DK, Bagshaw CR, Cooper A, Hawkins AR (2007) Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium. Protein Sci 16(11):2391\u20132402. https:\/\/doi.org\/10.1110\/ps.072900907","journal-title":"Protein Sci"},{"issue":"22","key":"5071_CR66","doi-asserted-by":"publisher","first-page":"7992","DOI":"10.1128\/JB.00959-06","volume":"188","author":"A Bharat","year":"2006","unstructured":"Bharat A, Jiang M, Sullivan SM, Maddock JR, Brown ED (2006) Cooperative and Critical Roles for Both G Domains in the GTPase Activity and Cellular Function of Ribosome-Associated Escherichia coli EngA. J Bacteriol 188(22):7992\u20137996. https:\/\/doi.org\/10.1128\/JB.00959-06","journal-title":"J Bacteriol"},{"issue":"2","key":"5071_CR67","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/15476286.2018.1564616","volume":"16","author":"C B\u00e1rria","year":"2019","unstructured":"B\u00e1rria C, Domingues S, Arraiano CM (2019) Pneumococcal RNase R globally impacts protein synthesis by regulating the amount of actively translating ribosomes. RNA Biol 16(2):211\u2013219. https:\/\/doi.org\/10.1080\/15476286.2018.1564616","journal-title":"RNA Biol"},{"key":"5071_CR68","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2023.04.019","volume":"204","author":"JS Reyes","year":"2023","unstructured":"Reyes JS, Fuentes-Lemus E, Romero J, Arenas F, Fierro A, Davies MJ, L\u00f3pez-Alarc\u00f3n C (2023) Peroxyl radicals modify 6-phosphogluconolactonase from Escherichia coli via oxidation of specific amino acids and aggregation which inhibits enzyme activity. Free Radic Biol Med 204:118\u2013127. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.04.019","journal-title":"Free Radic Biol Med"},{"key":"5071_CR69","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","volume":"66","author":"J Lu","year":"2014","unstructured":"Lu J, Holmgren A (2014) The thioredoxin antioxidant system. Free Radic Biol Med 66:75\u201387. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.07.036","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"5071_CR70","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1574-6976.2008.00104.x","volume":"32","author":"H Barreteau","year":"2008","unstructured":"Barreteau H, Kova\u010d A, Boniface A, Sova M, Gobec S, Blanot D (2008) Cytoplasmic steps of peptidoglycan biosynthesis. FEMS Microbiol Rev 32(2):168\u2013207. https:\/\/doi.org\/10.1111\/j.1574-6976.2008.00104.x","journal-title":"FEMS Microbiol Rev"},{"issue":"4","key":"5071_CR71","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3109\/07388551.2010.525498","volume":"31","author":"A Gautam","year":"2011","unstructured":"Gautam A, Vyas R, Tewari R (2011) Peptidoglycan biosynthesis machinery: A rich source of drug targets. Crit Rev Biotechnol 31(4):295\u2013336. https:\/\/doi.org\/10.3109\/07388551.2010.525498","journal-title":"Crit Rev Biotechnol"},{"issue":"50","key":"5071_CR72","doi-asserted-by":"publisher","first-page":"29717","DOI":"10.1074\/jbc.M115.680934","volume":"290","author":"K Hirabayashi","year":"2015","unstructured":"Hirabayashi K, Yuda E, Tanaka N, Katayama S, Iwasaki K, Matsumoto T, Kurisu G, Outten FW, Fukuyama K, Takahashi Y, Wada K (2015) Functional Dynamics Revealed by the Structure of the SufBCD Complex, a Novel ATP-binding Cassette (ABC) Protein That Serves as a Scaffold for Iron-Sulfur Cluster Biogenesis. J Biol Chem 290(50):29717\u201329731. https:\/\/doi.org\/10.1074\/jbc.M115.680934","journal-title":"J Biol Chem"},{"key":"5071_CR73","doi-asserted-by":"publisher","first-page":"102164","DOI":"10.1016\/j.redox.2021.102164","volume":"47","author":"AD Read","year":"2021","unstructured":"Read AD, Bentley REt, Archer SL, Dunham-Snary KJ (2021) Mitochondrial iron\u2013sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol 47:102164. https:\/\/doi.org\/10.1016\/j.redox.2021.102164","journal-title":"Redox Biol"},{"issue":"7","key":"5071_CR74","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1021\/acs.jproteome.3c00143","volume":"22","author":"X Xiao","year":"2023","unstructured":"Xiao X, Xiao X, Liu Y, Sun H, Liu X, Guo Z, Li Q, Sun W (2023) Metaproteomics Characterizes the Human Gingival Crevicular Fluid Microbiome Function in Periodontitis. J Proteome Res 22(7):2411\u20132420. https:\/\/doi.org\/10.1021\/acs.jproteome.3c00143","journal-title":"J Proteome Res"},{"issue":"3","key":"5071_CR75","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1600-051X.2011.01805.x","volume":"39","author":"RC Baliban","year":"2012","unstructured":"Baliban RC, Sakellari D, Li Z, DiMaggio PA, Garcia BA, Floudas CA (2012) Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples. J Clin Periodontol 39(3):203\u2013212. https:\/\/doi.org\/10.1111\/j.1600-051X.2011.01805.x","journal-title":"J Clin Periodontol"},{"issue":"13","key":"5071_CR76","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1002\/pmic.201100655","volume":"12","author":"S Tsuchida","year":"2012","unstructured":"Tsuchida S, Satoh M, Umemura H, Sogawa K, Kawashima Y, Kado S, Sawai S, Nishimura M, Kodera Y, Matsushita K, Nomura F (2012) Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers. Proteomics 12(13):2190\u20132202. https:\/\/doi.org\/10.1002\/pmic.201100655","journal-title":"Proteomics"},{"issue":"1","key":"5071_CR77","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/1873-3468.14247","volume":"596","author":"X Huang","year":"2022","unstructured":"Huang X, Lao W, Zhou Y, Sun Y, Wang Q (2022) Glutamate dehydrogenase enables Salmonella to survive under oxidative stress and escape from clearance in macrophages. FEBS Lett 596(1):81\u201394. https:\/\/doi.org\/10.1002\/1873-3468.14247","journal-title":"FEBS Lett"},{"issue":"27","key":"5071_CR78","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.1021\/bi200497y","volume":"50","author":"G Fibriansah","year":"2011","unstructured":"Fibriansah G, Veetil VP, Poelarends GJ, Thunnissen A-MWH (2011) Structural Basis for the Catalytic Mechanism of Aspartate Ammonia Lyase. Biochemistry 50(27):6053\u20136062. https:\/\/doi.org\/10.1021\/bi200497y","journal-title":"Biochemistry"},{"issue":"1","key":"5071_CR79","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00284-002-3807-5","volume":"46","author":"M Robichaux","year":"2003","unstructured":"Robichaux M, Howell M, Boopathy R (2003) Methanogenic Activity in Human Periodontal Pocket. Curr Microbiol 46(1):53\u201358. https:\/\/doi.org\/10.1007\/s00284-002-3807-5","journal-title":"Curr Microbiol"},{"issue":"4","key":"5071_CR80","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/jre.12031","volume":"48","author":"TE Rams","year":"2013","unstructured":"Rams TE, Degener JE, Van Winkelhoff AJ (2013) Prevalence of \u03b2-lactamase\u2010producing bacteria in human periodontitis. J Periodontal Res 48(4):493\u2013499. https:\/\/doi.org\/10.1111\/jre.12031","journal-title":"J Periodontal Res"},{"issue":"2","key":"5071_CR81","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1590\/1678-775720150469","volume":"24","author":"B Binta","year":"2016","unstructured":"Binta B, Patel M (2016) Detection of cfxA2, cfxA3, and cfxA6 genes in beta-lactamase producing oral anaerobes. J Appl Oral Sci 24(2):142\u2013147. https:\/\/doi.org\/10.1590\/1678-775720150469","journal-title":"J Appl Oral Sci"},{"key":"5071_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2022.102515","volume":"75","author":"N Kalali","year":"2022","unstructured":"Kalali N, Kadkhoda Z, Amid R, Ghourchian S, Douraghi M (2022) Identification of oral anaerobic bacteria and the beta-lactamase resistance genes from Iranian patients with periodontitis. Anaerobe 75:102515. https:\/\/doi.org\/10.1016\/j.anaerobe.2022.102515","journal-title":"Anaerobe"},{"issue":"8","key":"5071_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082222","volume":"19","author":"W Eiamphungporn","year":"2018","unstructured":"Eiamphungporn W, Schaduangrat N, Malik AA, Nantasenamat C (2018) Tackling the antibiotic resistance caused by class A \u03b2-lactamases through the use of \u03b2-lactamase inhibitory protein. Int J Mol Sci 19(8):2222. https:\/\/doi.org\/10.3390\/ijms19082222","journal-title":"Int J Mol Sci"},{"key":"5071_CR84","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1177\/00369330820270S102","volume":"27","author":"R Sutherland","year":"1982","unstructured":"Sutherland R (1982) Classification of \u00df-Lactamase-Producing Bacteria. Scott Med J 27:S3\u2013S9. https:\/\/doi.org\/10.1177\/00369330820270S102","journal-title":"Scott Med J"},{"issue":"2","key":"5071_CR85","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s13167-020-00202-5","volume":"11","author":"J Pei","year":"2020","unstructured":"Pei J, Li F, Xie Y, Liu J, Yu T, Feng X (2020) Microbial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach. EPMA J 11(2):197\u2013215. https:\/\/doi.org\/10.1007\/s13167-020-00202-5","journal-title":"EPMA J"},{"issue":"14","key":"5071_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144895","volume":"21","author":"GL Magrin","year":"2020","unstructured":"Magrin GL, Strauss FJ, Benfatti CAM, Maia LC, Gruber R (2020) Effects of short-chain fatty acids on human oral epithelial cells and the potential impact on periodontal disease: a systematic review of in vitro studies. Int J Mol Sci 21(14):4895. https:\/\/doi.org\/10.3390\/ijms21144895","journal-title":"Int J Mol Sci"},{"key":"5071_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/1796204","volume":"2021","author":"WF Rodrigues","year":"2021","unstructured":"Rodrigues WF, Miguel CB, Agostinho F, da Silva GV, Lazo-Chica JE, Naressi Scapin SM, Napimoga MH, Trindade-da-Silva CA, Krieger JE, Pereira ADC, Oliveira CJF, Soares SC, Ueira-Vieira C (2021) Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults. Mediators Inflamm 2021:1\u20138. https:\/\/doi.org\/10.1155\/2021\/1796204","journal-title":"Mediators Inflamm"},{"issue":"1","key":"5071_CR88","doi-asserted-by":"publisher","first-page":"A0047","DOI":"10.5702\/massspectrometry.A0047","volume":"5","author":"M Ozeki","year":"2016","unstructured":"Ozeki M, Nozaki T, Aoki J, Bamba T, Jensen KR, Murakami S, Toyoda M (2016) Metabolomic analysis of gingival crevicular fluid using gas chromatography\/mass spectrometry. Mass Spectrom 5(1):A0047. https:\/\/doi.org\/10.5702\/massspectrometry.A0047","journal-title":"Mass Spectrom"},{"key":"5071_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.573196","volume":"11","author":"M Shi","year":"2020","unstructured":"Shi M, Wei Y, Nie Y, Wang C, Sun F, Jiang W, Hu W, Wu X (2020) Alterations and correlations in microbial community and metabolome characteristics in generalized aggressive periodontitis. Front Microbiol 11:573196. https:\/\/doi.org\/10.3389\/fmicb.2020.573196","journal-title":"Front Microbiol"},{"issue":"7","key":"5071_CR90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268671","volume":"17","author":"K Hatanaka","year":"2022","unstructured":"Hatanaka K, Shirahase Y, Yoshida T, Kono M, Toya N, Sakasegawa SI, Konishi K, Yamamoto T, Ochiai K, Takashiba S (2022) Enzymatic measurement of short-chain fatty acids and application in periodontal disease diagnosis. PLoS One 17(7):e0268671. https:\/\/doi.org\/10.1371\/journal.pone.0268671","journal-title":"PLoS One"},{"issue":"5","key":"5071_CR91","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/jre.12579","volume":"53","author":"HW Chen","year":"2018","unstructured":"Chen HW, Zhou W, Liao Y, Hu SC, Chen TL, Song ZC (2018) Analysis of metabolic profiles of generalized aggressive periodontitis. J Periodontal Res 53(5):894\u2013901. https:\/\/doi.org\/10.1111\/jre.12579","journal-title":"J Periodontal Res"},{"issue":"9","key":"5071_CR92","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1177\/0022034509341967","volume":"88","author":"VM Barnes","year":"2009","unstructured":"Barnes VM, Teles R, Trivedi HM, Devizio W, Xu T, Mitchell MW, Milburn MV, Guo L (2009) Acceleration of purine degradation by periodontal diseases. J Dent Res 88(9):851\u2013855. https:\/\/doi.org\/10.1177\/0022034509341967","journal-title":"J Dent Res"},{"key":"5071_CR93","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1205829","volume":"13","author":"MT Shaku","year":"2023","unstructured":"Shaku MT, Ocius KL, Apostolos AJ, Pires MM, VanNieuwenhze MS, Dhar N, Kana BD (2023) Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking. Front Cell Infect Microbiol 13:1205829. https:\/\/doi.org\/10.3389\/fcimb.2023.1205829","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"5071_CR94","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/humu.21553","volume":"32","author":"SK Heibel","year":"2011","unstructured":"Heibel SK, Ah Mew N, Caldovic L, Daikhin Y, Yudkoff M, Tuchman M (2011) N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy. Hum Mutat 32(10):1153\u20131160. https:\/\/doi.org\/10.1002\/humu.21553","journal-title":"Hum Mutat"},{"issue":"4","key":"5071_CR95","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.niox.2005.11.009","volume":"14","author":"G Lerzynski","year":"2006","unstructured":"Lerzynski G, Suschek CV, Kolb-Bachofen V (2006) In hepatocytes the regulation of NOS-2 activity at physiological l-arginine levels suggests a close link to the urea cycle. Nitric Oxide 14(4):300\u2013308. https:\/\/doi.org\/10.1016\/j.niox.2005.11.009","journal-title":"Nitric Oxide"},{"issue":"5","key":"5071_CR96","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.3892\/etm.2019.8044","volume":"18","author":"Y Wang","year":"2019","unstructured":"Wang Y, Huang X, He F (2019) Mechanism and role of nitric oxide signaling in periodontitis. Exp Ther Med 18(5):3929\u20133935. https:\/\/doi.org\/10.3892\/etm.2019.8044","journal-title":"Exp Ther Med"},{"issue":"10","key":"5071_CR97","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/0006-2952(91)90581-o","volume":"42","author":"U F\u00f6rstermann","year":"1991","unstructured":"F\u00f6rstermann U, Schmidt HH, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F (1991) Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol 42(10):1849\u20131857. https:\/\/doi.org\/10.1016\/0006-2952(91)90581-o","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"5071_CR98","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1902\/jop.2011.100768","volume":"82","author":"BS Herrera","year":"2011","unstructured":"Herrera BS, Martins-Porto R, Maia-Dantas A, Campi P, Spolidorio LC, Costa SK, Van Dyke TE, Gyurko R, Muscara MN (2011) iNOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature\u2010induced periodontitis in rats. J Periodontol 82(11):1608\u20131615. https:\/\/doi.org\/10.1902\/jop.2011.100768","journal-title":"J Periodontol"},{"issue":"1","key":"5071_CR99","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-11-10","volume":"11","author":"P Gran","year":"2011","unstructured":"Gran P, Cameron-Smith D (2011) The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes. BMC Physiol 11(1):10. https:\/\/doi.org\/10.1186\/1472-6793-11-10","journal-title":"BMC Physiol"},{"key":"5071_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.827461","volume":"13","author":"Q Jiang","year":"2022","unstructured":"Jiang Q, Huang X, Yu W, Huang R, Zhao X, Chen C (2022) MTOR signaling in the regulation of CD4\u2009+\u2009T cell subsets in periodontal diseases. Front Immunol 13:827461. https:\/\/doi.org\/10.3389\/fimmu.2022.827461","journal-title":"Front Immunol"},{"issue":"3","key":"5071_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107836","volume":"35","author":"I Jialal","year":"2021","unstructured":"Jialal I, Patel A, Devaraj S, Adams-Huet B (2021) Metabolites that activate the inflammasome in nascent metabolic syndrome. J Diabetes Complicat 35(3):107836. https:\/\/doi.org\/10.1016\/j.jdiacomp.2020.107836","journal-title":"J Diabetes Complicat"},{"issue":"2","key":"5071_CR102","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.bbrc.2007.05.088","volume":"359","author":"IT Hwang","year":"2007","unstructured":"Hwang IT, Chung YM, Kim JJ, Chung JS, Kim BS, Kim HJ, Kim JS, Yoo YD (2007) Drug resistance to 5-FU linked to reactive oxygen species modulator 1. Biochem Biophys Res Commun 359(2):304\u2013310. https:\/\/doi.org\/10.1016\/j.bbrc.2007.05.088","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"5071_CR103","doi-asserted-by":"publisher","first-page":"7137","DOI":"10.4049\/jimmunol.179.10.7137","volume":"179","author":"E Kakazu","year":"2007","unstructured":"Kakazu E, Kanno N, Ueno Y, Shimosegawa T (2007) Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cells. J Immunol 179(10):7137\u20137146. https:\/\/doi.org\/10.4049\/jimmunol.179.10.7137","journal-title":"J Immunol"},{"issue":"7","key":"5071_CR104","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1902\/jop.2017.160813","volume":"88","author":"B Issaranggun Na Ayuthaya","year":"2017","unstructured":"Issaranggun Na Ayuthaya B, Everts V, Pavasant P (2017) Interleukin-12 induces receptor activator of nuclear factor\u2010kappa B ligand expression by human periodontal ligament cells. J Periodontol 88(7):e109\u2013e119. https:\/\/doi.org\/10.1902\/jop.2017.160813","journal-title":"J Periodontol"},{"issue":"10","key":"5071_CR105","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.4049\/jimmunol.180.10.6816","volume":"180","author":"SM Dann","year":"2008","unstructured":"Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L (2008) IL-6-Dependent Mucosal Protection Prevents Establishment of a Microbial Niche for Attaching\/Effacing Lesion-Forming Enteric Bacterial Pathogens. J Immunol 180(10):6816\u20136826. https:\/\/doi.org\/10.4049\/jimmunol.180.10.6816","journal-title":"J Immunol"},{"issue":"1","key":"5071_CR106","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/00220345970760010801","volume":"76","author":"R Niederman","year":"1997","unstructured":"Niederman R, Buyle-Bodin Y, Lu B-Y, Robinson P, Naleway C (1997) Short-chain carboxylic acid concentration in human gingival crevicular fluid. J Dent Res 76(1):575\u2013579. https:\/\/doi.org\/10.1177\/00220345970760010801","journal-title":"J Dent Res"},{"issue":"1","key":"5071_CR107","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1177\/154405910808700108","volume":"87","author":"T Kurita-Ochiai","year":"2008","unstructured":"Kurita-Ochiai T, Seto S, Suzuki N, Yamamoto M, Otsuka K, Abe K, Ochiai K (2008) Butyric acid induces apoptosis in inflamed fibroblasts. J Dent Res 87(1):51\u201355. https:\/\/doi.org\/10.1177\/154405910808700108","journal-title":"J Dent Res"},{"issue":"5","key":"5071_CR108","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051679","volume":"21","author":"GL Magrin","year":"2020","unstructured":"Magrin GL, Di Summa F, Strauss FJ, Panahipour L, Mildner M, Magalh\u00e3es Benfatti CA, Gruber R (2020) Butyrate decreases ICAM-1 expression in human oral squamous cell carcinoma cells. Int J Mol Sci 21(5):1679. https:\/\/doi.org\/10.3390\/ijms21051679","journal-title":"Int J Mol Sci"},{"issue":"3","key":"5071_CR109","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/07391102.2018.1433554","volume":"37","author":"M Kallubai","year":"2019","unstructured":"Kallubai M, Reddy SP, Dubey S, Ramachary DB, Subramanyam R (2019) Spectroscopic evaluation of synthesized 5\u03b2-dihydrocortisol and 5\u03b2-dihydrocortisol acetate binding mechanism with human serum albumin and their role in anticancer activity. J Biomol Struct Dyn 37(3):623\u2013640. https:\/\/doi.org\/10.1080\/07391102.2018.1433554","journal-title":"J Biomol Struct Dyn"},{"issue":"2","key":"5071_CR110","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.ajpath.2017.10.014","volume":"188","author":"IM Bugueno","year":"2018","unstructured":"Bugueno IM, Batool F, Korah L, Benkirane-Jessel N, Huck O (2018) Porphyromonas gingivalis Differentially Modulates Apoptosome Apoptotic Peptidase Activating Factor 1 in Epithelial Cells and Fibroblasts. Am J Pathol 188(2):404\u2013416. https:\/\/doi.org\/10.1016\/j.ajpath.2017.10.014","journal-title":"Am J Pathol"},{"issue":"18","key":"5071_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184338","volume":"25","author":"M Greabu","year":"2020","unstructured":"Greabu M, Giampieri F, Imre MM, Mohora M, Totan A, Pituru SM, Ionescu E (2020) Autophagy, one of the main steps in periodontitis pathogenesis and evolution. Molecules 25(18):4338. https:\/\/doi.org\/10.3390\/molecules25184338","journal-title":"Molecules"},{"issue":"1","key":"5071_CR112","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21461-4","volume":"12","author":"N Jones","year":"2021","unstructured":"Jones N, Blagih J, Zani F, Rees A, Hill DG, Jenkins BJ, Bull CJ, Moreira D, Bantan AIM, Cronin JG, Avancini D, Jones GW, Finlay DK, Vousden KH, Vincent EE, Thornton CA (2021) Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. Nat Commun 12(1):1209. https:\/\/doi.org\/10.1038\/s41467-021-21461-4","journal-title":"Nat Commun"},{"issue":"2","key":"5071_CR113","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/antiox4020322","volume":"4","author":"A Varela-L\u00f3pez","year":"2015","unstructured":"Varela-L\u00f3pez A, Quiles J, Cordero M, Giampieri F, Bull\u00f3n P (2015) Oxidative stress and dietary fat type in relation to periodontal disease. Antioxidants (Basel) 4(2):322\u2013344. https:\/\/doi.org\/10.3390\/antiox4020322","journal-title":"Antioxidants (Basel)"},{"key":"5071_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174810","volume":"919","author":"YN Cao","year":"2022","unstructured":"Cao YN, Wang Y, Zhang L, Hou Y, Shan J, Li M, Chen C, Zhou Y, Shan E, Wang J (2022) Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. Eur J Pharmacol 919:174810. https:\/\/doi.org\/10.1016\/j.ejphar.2022.174810","journal-title":"Eur J Pharmacol"},{"issue":"6086","key":"5071_CR115","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","volume":"336","author":"JK Nicholson","year":"2012","unstructured":"Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S (2012) Host-Gut Microbiota Metabolic Interactions. Science 336(6086):1262\u20131267. https:\/\/doi.org\/10.1126\/science.1223813","journal-title":"Science"},{"issue":"1","key":"5071_CR116","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01926-14","volume":"6","author":"B Shi","year":"2015","unstructured":"Shi B, Chang M, Martin J, Mitreva M, Lux R, Klokkevold P, Sodergren E, Weinstock GM, Haake SK, Li H (2015) Dynamic changes in the subgingival microbiome and their potential for diagnosis and prognosis of periodontitis. mBio 6(1):e01926-14. https:\/\/doi.org\/10.1128\/mBio.01926-14","journal-title":"mBio"},{"issue":"4","key":"5071_CR117","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00162-21","volume":"6","author":"Y Kang","year":"2021","unstructured":"Kang Y, Sun B, Chen Y, Lou Y, Zheng M, Li Z (2021) Dental plaque microbial resistomes of periodontal health and disease and their changes after scaling and root planing therapy. mSphere 6(4):e00162-21. https:\/\/doi.org\/10.1128\/mSphere.00162-21","journal-title":"mSphere"},{"issue":"1","key":"5071_CR118","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/prd.12358","volume":"85","author":"M Feres","year":"2021","unstructured":"Feres M, Retamal-Valdes B, Gon\u00e7alves C, Cristina Figueiredo L, Teles F (2021) Did Omics change periodontal therapy? Periodontol 2000 85(1):182\u2013209. https:\/\/doi.org\/10.1111\/prd.12358","journal-title":"Periodontol 2000"},{"issue":"3","key":"5071_CR119","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s10096-015-2555-y","volume":"35","author":"FS Martelli","year":"2016","unstructured":"Martelli FS, Fanti E, Rosati C, Martelli M, Bacci G, Martelli ML, Medico E (2016) Long-term efficacy of microbiology-driven periodontal laser-assisted therapy. Eur J Clin Microbiol Infect Dis 35(3):423\u2013431. https:\/\/doi.org\/10.1007\/s10096-015-2555-y","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"5071_CR120","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2174\/1874210601206010255","volume":"6","author":"T Laksmana","year":"2012","unstructured":"Laksmana T, Kittichotirat W, Huang Y, Chen W, Jorgensen M, Bumgarner R, Chen C (2012) Metagenomic analysis of subgingival microbiota following non-surgical periodontal therapy: a pilot study. Open Dent J 6(1):255\u2013261. https:\/\/doi.org\/10.2174\/1874210601206010255","journal-title":"Open Dent J"},{"issue":"11","key":"5071_CR121","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1111\/jcpe.12155","volume":"40","author":"W Teughels","year":"2013","unstructured":"Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC (2013) Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 40(11):1025\u20131035. https:\/\/doi.org\/10.1111\/jcpe.12155","journal-title":"J Clin Periodontol"},{"issue":"6","key":"5071_CR122","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1902\/jop.2015.140612","volume":"86","author":"G \u0130nce","year":"2015","unstructured":"\u0130nce G, G\u00fcrsoy H, \u0130p\u00e7i \u015eD, Cakar G, Emekli-Alturfan E, Y\u0131lmaz S (2015) Clinical and biochemical evaluation of lozenges containing Lactobacillus reuteri as an adjunct to non\u2010surgical periodontal therapy in chronic periodontitis. J Periodontol 86(6):746\u2013754. https:\/\/doi.org\/10.1902\/jop.2015.140612","journal-title":"J Periodontol"},{"issue":"6","key":"5071_CR123","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4103\/jisp.jisp_114_21","volume":"25","author":"GM El-bagoory","year":"2021","unstructured":"El-bagoory GM, El-guindy H, Shoukheba MM, El-zamarany E (2021) The adjunctive effect of probiotics to nonsurgical treatment of chronic periodontitis: A randomized controlled clinical trial. J Indian Soc Periodontol 25(6):525. https:\/\/doi.org\/10.4103\/jisp.jisp_114_21","journal-title":"J Indian Soc Periodontol"},{"issue":"2","key":"5071_CR124","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4103\/2279-042X.179568","volume":"5","author":"S Penala","year":"2016","unstructured":"Penala S, Kalakonda B, Pathakota KR, Jayakumar A, Koppolu P, Lakshmi BV, Pandey R, Mishra A (2016) Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: A randomized controlled trial. J Res Pharm Pract 5(2):86. https:\/\/doi.org\/10.4103\/2279-042X.179568","journal-title":"J Res Pharm Pract"},{"issue":"6","key":"5071_CR125","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1002\/JPER.22-0505","volume":"94","author":"AN Colamarino","year":"2023","unstructured":"Colamarino AN, Johnson TM, Boudreaux DM, Dutner JM, Stancoven BW, Lincicum AR, Akers JA (2023) Influence of Lactobacillus reuteri, Bifidobacterium animalis subsp. lactis, and prebiotic inulin on dysbiotic dental biofilm composition ex vivo. J Periodontol 94(6):793\u2013804. https:\/\/doi.org\/10.1002\/JPER.22-0505","journal-title":"J Periodontol"},{"issue":"1","key":"5071_CR126","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69931-x","volume":"10","author":"BT Rosier","year":"2020","unstructured":"Rosier BT, Buetas E, Moya-Gonzalvez EM, Artacho A, Mira A (2020) Nitrate as a potential prebiotic for the oral microbiome. Sci Rep 10(1):12895. https:\/\/doi.org\/10.1038\/s41598-020-69931-x","journal-title":"Sci Rep"},{"issue":"9","key":"5071_CR127","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/jcpe.12987","volume":"45","author":"YLAS Levi","year":"2018","unstructured":"Levi YLAS, Novais GS, Dias RB, Andraus RAC, Messora MR, Neto HB, Ervolino E, Santinoni CS, Maia LP (2018) Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats. J Clin Periodontol 45(9):1078\u20131089. https:\/\/doi.org\/10.1111\/jcpe.12987","journal-title":"J Clin Periodontol"},{"issue":"9","key":"5071_CR128","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/nu9091016","volume":"9","author":"O De","year":"2017","unstructured":"De O, Silva V, Lobato RV, Andrade EF, Orlando DR, Borges BDB, Zangeronimo MG, de Sousa RV, Pereira LJ (2017) Effects of \u03b2-Glucans Ingestion on Alveolar Bone Loss, Intestinal Morphology, Systemic Inflammatory Profile, and Pancreatic \u03b2-Cell Function in Rats with Periodontitis and Diabetes. Nutrients 9(9):1016. https:\/\/doi.org\/10.3390\/nu9091016","journal-title":"Nutrients"},{"issue":"6","key":"5071_CR129","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.sdentj.2022.06.002","volume":"34","author":"AM Gafar","year":"2022","unstructured":"Gafar AM, Ramadan AM, ElSaid NA, Nurelhuda NM (2022) Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled trial. Saudi Dent J 34(6):494\u2013502. https:\/\/doi.org\/10.1016\/j.sdentj.2022.06.002","journal-title":"Saudi Dent J"},{"issue":"4","key":"5071_CR130","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/jcpe.12700","volume":"44","author":"V Slomka","year":"2017","unstructured":"Slomka V, Hernandez-Sanabria E, Herrero ER, Zaidel L, Bernaerts K, Boon N, Quirynen M, Teughels W (2017) Nutritional stimulation of commensal oral bacteria suppresses pathogens: the prebiotic concept. J Clin Periodontol 44(4):344\u2013352. https:\/\/doi.org\/10.1111\/jcpe.12700","journal-title":"J Clin Periodontol"},{"key":"5071_CR131","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2147\/IDR.S232982","volume":"13","author":"A Barzegari","year":"2020","unstructured":"Barzegari A, Kheyrolahzadeh K, Hosseiniyan Khatibi SM, Sharifi S, Memar MY, Zununi Vahed S (2020) The battle of probiotics and their derivatives against biofilms. Infect Drug Resist 13:659\u2013672. https:\/\/doi.org\/10.2147\/IDR.S232982","journal-title":"Infect Drug Resist"},{"issue":"1","key":"5071_CR132","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1805553","volume":"12","author":"KH Ishikawa","year":"2020","unstructured":"Ishikawa KH, Mita D, Kawamoto D, Nicoli JR, Albuquerque-Souza E, Lorenzetti Simionato MR, Mayer MPA (2020) Probiotics alter biofilm formation and the transcription of Porphyromonas gingivalis virulence-associated genes. J Oral Microbiol 12(1):1805553. https:\/\/doi.org\/10.1080\/20002297.2020.1805553","journal-title":"J Oral Microbiol"},{"key":"5071_CR133","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jdsr.2023.02.001","volume":"59","author":"F Ausenda","year":"2023","unstructured":"Ausenda F, Barbera E, Cotti E, Romeo E, Natto ZS, Valente NA (2023) Clinical, microbiological and immunological short, medium and long-term effects of different strains of probiotics as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Systematic review with meta-analysis. Jpn Dent Sci Rev 59:62\u2013103. https:\/\/doi.org\/10.1016\/j.jdsr.2023.02.001","journal-title":"Jpn Dent Sci Rev"},{"issue":"1","key":"5071_CR134","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/02648725.2023.2183617","volume":"40","author":"K Zhou","year":"2023","unstructured":"Zhou K, Xie J, Su Y, Fang J (2023) Lactobacillus reuteri for chronic periodontitis: focus on underlying mechanisms and future perspectives. Biotechnol Genet Eng Rev 40(1):381\u2013408. https:\/\/doi.org\/10.1080\/02648725.2023.2183617","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"9","key":"5071_CR135","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1038\/ismej.2016.26","volume":"10","author":"SR Lindemann","year":"2016","unstructured":"Lindemann SR, Bernstein HC, Song HS, Fredrickson JK, Fields MW, Shou W, Johnson DR, Beliaev AS (2016) Engineering microbial consortia for controllable outputs. ISME J 10(9):2077\u20132084. https:\/\/doi.org\/10.1038\/ismej.2016.26","journal-title":"ISME J"},{"issue":"6","key":"5071_CR136","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1111\/1462-2920.12343","volume":"16","author":"K De Roy","year":"2014","unstructured":"De Roy K, Marzorati M, Van Den Abbeele P, Van De Wiele T, Boon N (2014) Synthetic microbial ecosystems: an exciting tool to understand and apply microbial communities. Environ Microbiol 16(6):1472\u20131481. https:\/\/doi.org\/10.1111\/1462-2920.12343","journal-title":"Environ Microbiol"},{"issue":"6242","key":"5071_CR137","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1126\/science.aab0946","volume":"348","author":"JK Fredrickson","year":"2015","unstructured":"Fredrickson JK (2015) Ecological communities by design. Science 348(6242):1425\u20131427. https:\/\/doi.org\/10.1126\/science.aab0946","journal-title":"Science"},{"issue":"7","key":"5071_CR138","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1172\/JCI79214","volume":"125","author":"TC Shen","year":"2015","unstructured":"Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD (2015) Engineering the gut microbiota to treat hyperammonemia. J Clin Invest 125(7):2841\u20132850. https:\/\/doi.org\/10.1172\/JCI79214","journal-title":"J Clin Invest"},{"issue":"1","key":"5071_CR139","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1038\/s41467-021-23460-x","volume":"12","author":"D Van der Lelie","year":"2021","unstructured":"Van der Lelie D, Oka A, Taghavi S, Umeno J, Fan TJ, Merrell KE, Watson SD, Ouellette L, Liu B, Awoniyi M, Lai Y, Chi L, Lu K, Henry CS, Sartor RB (2021) Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis. Nat Commun 12(1):3105. https:\/\/doi.org\/10.1038\/s41467-021-23460-x","journal-title":"Nat Commun"},{"key":"5071_CR140","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3389\/fcimb.2019.00246","volume":"9","author":"KN Mendez","year":"2019","unstructured":"Mendez KN, Hoare A, Soto C, Bugue\u00f1o I, Olivera M, Meneses C, P\u00e9rez-Donoso JM, Castro-Nallar E, Bravo D (2019) Variability in Genomic and Virulent Properties of Porphyromonas gingivalis Strains Isolated From Healthy and Severe Chronic Periodontitis Individuals. Front Cell Infect Microbiol 9:246. https:\/\/doi.org\/10.3389\/fcimb.2019.00246","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"5071_CR141","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/srep01843","volume":"3","author":"J Wang","year":"2013","unstructured":"Wang J, Qi J, Zhao H, He S, Zhang Y, Wei S, Zhao F (2013) Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease. Sci Rep 3(1):1843. https:\/\/doi.org\/10.1038\/srep01843","journal-title":"Sci Rep"},{"issue":"7","key":"5071_CR142","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067719","volume":"8","author":"A Gmiterek","year":"2013","unstructured":"Gmiterek A, W\u00f3jtowicz H, Mackiewicz P, Radwan-Oczko M, Kantorowicz M, Chomyszyn-Gajewska M, Fr\u0105szczak M, Bielecki M, Olczak M, Olczak T (2013) The unique hmuY gene sequence as a specific marker of Porphyromonas gingivalis. PLoS One 8(7):e67719. https:\/\/doi.org\/10.1371\/journal.pone.0067719","journal-title":"PLoS One"},{"issue":"3","key":"5071_CR143","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/jre.12846","volume":"56","author":"A Barbour","year":"2021","unstructured":"Barbour A, Glogauer J, Grinfeld L, Ostadsharif Memar R, Fine N, Tenenbaum H, Glogauer M (2021) The role of CRISPR-Cas in advancing precision periodontics. J Periodontal Res 56(3):454\u2013461. https:\/\/doi.org\/10.1111\/jre.12846","journal-title":"J Periodontal Res"},{"key":"5071_CR144","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.757327","volume":"12","author":"A Luo","year":"2022","unstructured":"Luo A, Wang F, Sun D, Liu X, Xin B (2022) Formation, development, and cross-species interactions in biofilms. Front Microbiol 12:757327. https:\/\/doi.org\/10.3389\/fmicb.2021.757327","journal-title":"Front Microbiol"},{"issue":"1","key":"5071_CR145","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1128\/AAC.00919-15","volume":"60","author":"Z Ren","year":"2016","unstructured":"Ren Z, Cui T, Zeng J, Chen L, Zhang W, Xu X, Cheng L, Li M, Li J, Zhou X, Li Y (2016) Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence. Antimicrob Agents Chemother 60(1):126\u2013135. https:\/\/doi.org\/10.1128\/AAC.00919-15","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"5071_CR146","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/omi.12247","volume":"33","author":"T Gong","year":"2018","unstructured":"Gong T, Tang B, Zhou X, Zeng J, Lu M, Guo X, Peng X, Lei L, Gong B, Li Y (2018) Genome editing in Streptococcus mutans through self-targeting CRISPR arrays. Mol Oral Microbiol 33(6):440\u2013449. https:\/\/doi.org\/10.1111\/omi.12247","journal-title":"Mol Oral Microbiol"},{"issue":"9","key":"5071_CR147","doi-asserted-by":"publisher","first-page":"4732","DOI":"10.1021\/pr100446f","volume":"9","author":"MM Grant","year":"2010","unstructured":"Grant MM, Creese AJ, Barr G, Ling MR, Scott AE, Matthews JB, Griffiths HR, Cooper HJ, Chapple IL (2010) Proteomic Analysis of a Noninvasive Human Model of Acute Inflammation and Its Resolution: The Twenty-one Day Gingivitis Model. J Proteome Res 9(9):4732\u20134744. https:\/\/doi.org\/10.1021\/pr100446f","journal-title":"J Proteome Res"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-05071-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-05071-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-05071-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:02:42Z","timestamp":1790092962000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00284-026-05071-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":147,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5071"],"URL":"https:\/\/doi.org\/10.1007\/s00284-026-05071-1","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"14 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. Our manuscript does not contain data from any individual person. All authors consent for publication of this review.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"488"}}