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Paroxetine (PRX), a selective serotonin reuptake inhibitor, has demonstrated antibiofilm activity against both\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . However, studies evaluating PRX\u2019s activity against polymicrobial biofilms remain scarce. Consequently, we investigated the activity of PRX against mixed biofilms of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , as well as its potential to prevent the formation of such biofilms on peripheral venous catheters. Our findings revealed that PRX not only prevented biofilm formation but also significantly reduced both the viability and biomass of these structures, possibly by disrupting the polysaccharide matrix. When impregnated in peripheral venous catheters, PRX also inhibited the excessive growth of microbial communities, making it a potentially effective agent to modulate the structure and susceptibility of multispecies biofilms, expanding its spectrum of action to more complex clinical scenarios associated with medical devices.\n                  <\/jats:p>","DOI":"10.1007\/s00284-026-05088-6","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:42:37Z","timestamp":1790844157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive Activity of Paroxetine Against the Formation of Mixed Biofilms of Candida albicans and Staphylococcus aureus on Peripheral Venous Catheters"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-2782","authenticated-orcid":false,"given":"L\u00edvia Gurgel do","family":"Amaral Valente S\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-1747","authenticated-orcid":false,"given":"\u00c9rica Rayanne Mota da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-5671","authenticated-orcid":false,"given":"Maria Janielly Castelo Branco","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-7200","authenticated-orcid":false,"given":"Vit\u00f3ria Pessoa de","family":"Farias Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Santos","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4545-9442","authenticated-orcid":false,"given":"Leilson Carvalho de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0971-1311","authenticated-orcid":false,"given":"Thais Lima","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-8243","authenticated-orcid":false,"given":"Daniel Sampaio","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-1258","authenticated-orcid":false,"given":"Lara Elloyse Almeida","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3934-8825","authenticated-orcid":false,"given":"Vit\u00f3ria Monteiro","family":"Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6803-2789","authenticated-orcid":false,"given":"Vit\u00f3ria Gir\u00e3o dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-3012","authenticated-orcid":false,"given":"Jo\u00e3o Batista de","family":"Andrade Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-5882","authenticated-orcid":false,"given":"H\u00e9lio Vitoriano Nobre","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-351X","authenticated-orcid":false,"given":"Cec\u00edlia Rocha da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"5088_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2449085","author":"N Kaku","year":"2025","unstructured":"Kaku N, Ishige M, Yasutake G, Sasaki D, Ota K, Mitsumoto-Kaseida F et al (2025) Long-term impact of molecular epidemiology shifts of methicillin-resistant Staphylococcus aureus on severity and mortality of bloodstream infection. 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