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Experimental models that reproduce natural routes of exposure and allow integrated analyses of host responses remain limited. In this study, we established and characterized an immersion-based infection model of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    in adult zebrafish (\n                    <jats:italic>Danio rerio<\/jats:italic>\n                    ) to investigate systemic, behavioral, immunological, oxidative, and histopathological outcomes. Adult zebrafish were exposed by immersion to different fungal concentrations (1\u2009\u00d7\u200910\u2076 or 1\u2009\u00d7\u200910\u2078 CFU\/mL) for 10\u201324\u00a0h. Fungal burden, exploratory behavior, antioxidant capacity (ABTS), TNF-\u03b1 levels, and tissue alterations were subsequently assessed. Exposure to 1\u2009\u00d7\u200910\u2078 CFU\/mL for 24\u00a0h resulted in a significant increase in fungal burden without inducing mortality, characterizing a sublethal infection. Infection modulated behavioral parameters, tissue-specific alterations in antioxidant activity and a marked reduction of TNF-\u03b1 levels in the liver and brain were observed, suggesting disruption of immune-redox homeostasis. Histopathological analyses revealed mild inflammatory responses and increased melanomacrophage accumulation, particularly in skin and gills tissues. Overall, this study demonstrates that adult zebrafish immersion constitutes a biologically relevant and translational model for investigating candidiasis, enabling integrated evaluation of host\u2013pathogen interactions and systemic responses under environmentally relevant conditions.\n                  <\/jats:p>","DOI":"10.1007\/s00284-026-05109-4","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:24:39Z","timestamp":1787739879000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immersion-Based Candida albicans Infection in Adult Zebrafish Induces Distinct Behavioral, Immune and Oxidative Responses in a Dose- and Time-Dependent Manner"],"prefix":"10.1007","volume":"83","author":[{"given":"Marcos Ot\u00e1vio","family":"Bueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Cervini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Cataldo","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Tony","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudriana","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Centa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Colombo","family":"Dal-Pont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo","family":"Assolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"5109_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1590\/S1676-24442010000300009","volume":"46","author":"MP Giolo","year":"2010","unstructured":"Giolo MP, Svidzinski TIE (2010) Fisiopatogenia, epidemiologia e diagn\u00f3stico laboratorial da candidemia. 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