{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:31:24Z","timestamp":1793345484205,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hangzhou Municipal Natural Science Foundation","award":["2025SZRJJ0718"],"award-info":[{"award-number":["2025SZRJJ0718"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330098"],"award-info":[{"award-number":["82330098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273531"],"award-info":[{"award-number":["82273531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of the Innovation Program of Shanghai Municipal Education Commission","award":["2021-01-07-00-07-E00078"],"award-info":[{"award-number":["2021-01-07-00-07-E00078"]}],"id":[{"id":"https:\/\/ror.org\/05tewj457","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Clinical Research Funding of Shanghai Municipal Health Commission","award":["202440121"],"award-info":[{"award-number":["202440121"]}]},{"name":"Program of Shanghai Academic\/Technology Research Leader","award":["23XD1400400"],"award-info":[{"award-number":["23XD1400400"]}]},{"name":"Clinical Research Plan of Shanghai Shenkang Hospital Development Center","award":["SHDC22022302"],"award-info":[{"award-number":["SHDC22022302"]}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["No. 2023ZZ02018"],"award-info":[{"award-number":["No. 2023ZZ02018"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["No-shslczdzk01002"],"award-info":[{"award-number":["No-shslczdzk01002"]}]},{"name":"Shanghai Municipal Commission of Science and Technology","award":["23Y31920300"],"award-info":[{"award-number":["23Y31920300"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Microbiol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00284-026-05167-8","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:29:46Z","timestamp":1790436586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole Genome Sequencing Reveals Antibiotic Resistance Heterogeneity and Metabolic Signatures of Cutibacterium acnes in Atopic Dermatitis"],"prefix":"10.1007","volume":"83","author":[{"given":"Tianze","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"10478","key":"5167_CR1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0140-6736(24)02519-4","volume":"405","author":"E Guttman-Yassky","year":"2025","unstructured":"Guttman-Yassky E, Renert-Yuval Y (2025) Brunner. Atopic dermatitis[J]. Lancet 405(10478):583\u2013596","journal-title":"Lancet"},{"issue":"12","key":"5167_CR2","doi-asserted-by":"publisher","first-page":"adv00164","DOI":"10.2340\/00015555-3514","volume":"100","author":"SM Edslev","year":"2020","unstructured":"Edslev SM, Agner T, Andersen PS (2020) Skin microbiome in atopic dermatitis[J]. Acta Derm Venereol 100(12):adv00164","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"5167_CR3","doi-asserted-by":"publisher","first-page":"490","DOI":"10.2340\/00015555-2896","volume":"98","author":"W Francuzik","year":"2018","unstructured":"Francuzik W, Franke K, Schumann RR, Heine G, Worm M (2018) Propionibacterium acnes abundance correlates inversely with staphylococcus aureus: Data from atopic dermatitis skin microbiome[J]. Acta Derm Venereol 98(5):490\u2013495","journal-title":"Acta Derm Venereol"},{"key":"5167_CR4","doi-asserted-by":"crossref","unstructured":"Qiu Z, Zhu Z, Liu X, Chen B, Yin H, Gu C et al (2022) A dysregulated sebum-microbial metabolite-il-33 axis initiates skin inflammation in atopic dermatitis[J]. J Exp Med, 219(10):e20212397","DOI":"10.1084\/jem.20212397"},{"issue":"7","key":"5167_CR5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.chom.2024.06.002","volume":"32","author":"T Yu","year":"2024","unstructured":"Yu T, Xu X, Liu Y, Wang X, Wu S, Qiu Z et al (2024) Multi-omics signatures reveal genomic and functional heterogeneity of cutibacterium acnes in normal and diseased skin[J]. Cell Host Microbe 32(7):1129\u20131146e1128","journal-title":"Cell Host Microbe"},{"issue":"Suppl 2","key":"5167_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/jdv.15043","volume":"32","author":"B Dr\u00e9no","year":"2018","unstructured":"Dr\u00e9no B, P\u00e9castaings S, Corvec S, Veraldi S, Khammari A (2018) Roques. Cutibacterium acnes (propionibacterium acnes) and acne vulgaris: A brief look at the latest updates[J]. J Eur Acad Dermatol Venereol 32(Suppl 2):5\u201314","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"5167_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s40257-018-00417-3","volume":"20","author":"H Xu","year":"2019","unstructured":"Xu H, Li H (2019) Acne, the skin microbiome, and antibiotic treatment[J]. Am J Clin Dermatol 20(3):335\u2013344","journal-title":"Am J Clin Dermatol"},{"issue":"6","key":"5167_CR8","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1111\/1346-8138.16757","volume":"50","author":"S Koyanagi","year":"2023","unstructured":"Koyanagi S, Koizumi J, Nakase K, Hayashi N, Horiuchi Y, Watanabe K et al (2023) Increased frequency of clindamycin-resistant cutibacterium acnes strains isolated from japanese patients with acne vulgaris caused by the prevalence of exogenous resistance genes[J]. J Dermatol 50(6):793\u2013799","journal-title":"J Dermatol"},{"issue":"9","key":"5167_CR9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/j.1346-8138.2011.01423.x","volume":"39","author":"K Nakase","year":"2012","unstructured":"Nakase K, Nakaminami H, Noguchi N, Nishijima S, Sasatsu M (2012) First report of high levels of clindamycin-resistant propionibacterium acnes carrying erm(x) in japanese patients with acne vulgaris[J]. J Dermatol 39(9):794\u2013796","journal-title":"J Dermatol"},{"issue":"Suppl 5","key":"5167_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jdv.19125","volume":"37","author":"AL Demessant-Flavigny","year":"2023","unstructured":"Demessant-Flavigny AL, Conn\u00e9table S, Kerob D, Moreau M, Aguilar L, Wollenberg A (2023) Skin microbiome dysbiosis and the role of staphylococcus aureus in atopic dermatitis in adults and children: A narrative review[J]. J Eur Acad Dermatol Venereol 37(Suppl 5):3\u201317","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5167_CR11","doi-asserted-by":"crossref","unstructured":"Partridge SR, Kwong SM, Firth N, Jensen SO (2018) Mobile genetic elements associated with antimicrobial resistance[J]. Clin Microbiol Rev, 31(4):e00088-17","DOI":"10.1128\/CMR.00088-17"},{"issue":"1","key":"5167_CR12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40168-020-00995-7","volume":"9","author":"Z Li","year":"2021","unstructured":"Li Z, Xia J, Jiang L, Tan Y, An Y, Zhu X et al (2021) Characterization of the human skin resistome and identification of two microbiota cutotypes[J]. Microbiome 9(1):47","journal-title":"Microbiome"},{"key":"5167_CR13","doi-asserted-by":"publisher","first-page":"1433783","DOI":"10.3389\/fcimb.2024.1433783","volume":"14","author":"A Podbielski","year":"2024","unstructured":"Podbielski A, K\u00f6ller T, Warnke P, Barrantes I, Kreikemeyer B (2024) Whole genome sequencing distinguishes skin colonizing from infection-associated cutibacterium acnes isolates[J]. Front Cell Infect Microbiol 14:1433783","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"5167_CR14","doi-asserted-by":"publisher","first-page":"e15150","DOI":"10.1111\/exd.15150","volume":"33","author":"CT Cheung","year":"2024","unstructured":"Cheung CT, Lancien U, Corvec S, Mengeaud V, Mias C, V\u00e9ziers J et al (2024) Pro-inflammatory activity of cutibacterium acnes phylotype ia(1) and extracellular vesicles: An in vitro study[J]. Exp Dermatol 33(8):e15150","journal-title":"Exp Dermatol"},{"key":"5167_CR15","unstructured":"CLSI (2018) Methods for antimicrobial susceptibility testing of anaerobic bacteria. 9th ed. CLSI standard M11. Wayne, PA: Clinical and laboratory standards institute"},{"key":"5167_CR16","unstructured":"CLSI (2026) Performance standards for antimicrobial susceptibility testing. 36th ed. CLSI supplement M100. Clinical and Laboratory Standards Institute"},{"issue":"4","key":"5167_CR17","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s13555-019-00320-7","volume":"9","author":"N Zhang","year":"2019","unstructured":"Zhang N, Yuan R, Xin KZ, Lu Z, Ma Y (2019) Antimicrobial susceptibility, biotypes and phylotypes of clinical cutibacterium (formerly propionibacterium) acnes strains isolated from acne patients: An observational study[J]. Dermatol Ther (Heidelb) 9(4):735\u2013746","journal-title":"Dermatol Ther (Heidelb)"},{"key":"5167_CR18","doi-asserted-by":"publisher","first-page":"102169","DOI":"10.1016\/j.anaerobe.2020.102169","volume":"62","author":"J Sutcliffe","year":"2020","unstructured":"Sutcliffe J, Mclaughlin R, Webster G, Read AF, Drlica K, Elliott R et al (2020) Susceptibility of cutibacterium acnes to topical minocycline foam[J]. Anaerobe 62:102169","journal-title":"Anaerobe"},{"issue":"2","key":"5167_CR19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ijantimicag.2015.12.004","volume":"47","author":"LJ Sherrard","year":"2016","unstructured":"Sherrard LJ, Mcgrath SJ, Mcilreavey L, Hatch J, Wolfgang MC, Muhlebach MS et al (2016) Production of extended-spectrum \u03b2-lactamases and the potential indirect pathogenic role of prevotella isolates from the cystic fibrosis respiratory microbiota[J]. Int J Antimicrob Agents 47(2):140\u2013145","journal-title":"Int J Antimicrob Agents"},{"issue":"Pt 2","key":"5167_CR20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1099\/jmm.0.065789-0","volume":"63","author":"M Woegerbauer","year":"2014","unstructured":"Woegerbauer M, Zeinzinger J, Springer B, Hufnagl P, Indra A, Korschineck I et al (2014) Prevalence of the aminoglycoside phosphotransferase genes aph(3\u2019)-iiia and aph(3\u2019)-iia in escherichia coli, enterococcus faecalis, enterococcus faecium, pseudomonas aeruginosa, salmonella enterica subsp. Enterica and staphylococcus aureus isolates in austria[J]. J Med Microbiol 63(Pt 2):210\u2013217","journal-title":"J Med Microbiol"},{"key":"5167_CR21","doi-asserted-by":"crossref","unstructured":"Ousmane S, Diallo BA, Ouedraogo R (2018) Genetic determinants of tetracycline resistance in clinical streptococcus pneumoniae serotype 1 isolates from niger[J]. Antibiot (Basel), 7(1):19","DOI":"10.3390\/antibiotics7010019"},{"issue":"7","key":"5167_CR22","doi-asserted-by":"publisher","first-page":"e41480","DOI":"10.1371\/journal.pone.0041480","volume":"7","author":"A Mcdowell","year":"2012","unstructured":"Mcdowell A, Barnard E, Nagy I, Gao A, Tomida S, Li H et al (2012) An expanded multilocus sequence typing scheme for propionibacterium acnes: Investigation of \u2018pathogenic\u2019, \u2018commensal\u2019 and antibiotic resistant strains[J]. PLoS ONE 7(7):e41480","journal-title":"PLoS ONE"},{"key":"5167_CR23","doi-asserted-by":"publisher","first-page":"1565111","DOI":"10.3389\/fmicb.2025.1565111","volume":"16","author":"C Zhu","year":"2025","unstructured":"Zhu C, Wei B, Li Y, Wang C (2025) Antibiotic resistance rates in cutibacterium acnes isolated from patients with acne vulgaris: A systematic review and meta-analysis[J]. Front Microbiol 16:1565111","journal-title":"Front Microbiol"},{"issue":"4","key":"5167_CR24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11684-016-0480-9","volume":"10","author":"Y Ma","year":"2016","unstructured":"Ma Y, Zhang N, Wu S, Huang H, Cao Y (2016) Antimicrobial activity of topical agents against propionibacterium acnes: An in vitro study of clinical isolates from a hospital in shanghai, china[J]. Front Med 10(4):517\u2013521","journal-title":"Front Med"},{"key":"5167_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.anaerobe.2014.10.007","volume":"31","author":"L Giannopoulos","year":"2015","unstructured":"Giannopoulos L, Papaparaskevas J, Refene E, Daikos G, Stavrianeas N, Tsakris A (2015) Mlst typing of antimicrobial-resistant propionibacterium acnes isolates from patients with moderate to severe acne vulgaris[J]. Anaerobe 31:50\u201354","journal-title":"Anaerobe"},{"issue":"9","key":"5167_CR26","doi-asserted-by":"publisher","first-page":"e70897","DOI":"10.1371\/journal.pone.0070897","volume":"8","author":"A Mcdowell","year":"2013","unstructured":"Mcdowell A, Nagy I, Magyari M, Barnard E, Patrick S (2013) The opportunistic pathogen propionibacterium acnes: Insights into typing, human disease, clonal diversification and camp factor evolution[J]. PLoS ONE 8(9):e70897","journal-title":"PLoS ONE"},{"issue":"1","key":"5167_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1099\/jmm.0.000875","volume":"68","author":"S Aoki","year":"2019","unstructured":"Aoki S, Nakase K, Hayashi N, Noguchi N (2019) Transconjugation of erm(x) conferring high-level resistance of clindamycin for cutibacterium acnes[J]. J Med Microbiol 68(1):26\u201330","journal-title":"J Med Microbiol"},{"key":"5167_CR28","doi-asserted-by":"publisher","first-page":"952081","DOI":"10.3389\/fmicb.2022.952081","volume":"13","author":"A Camargo","year":"2022","unstructured":"Camargo A, Guerrero-Araya E, Casta\u00f1eda S, Vega L, Cardenas-Alvarez MX, Rodr\u00edguez C et al (2022) Intra-species diversity of clostridium perfringens: A diverse genetic repertoire reveals its pathogenic potential[J]. Front Microbiol 13:952081","journal-title":"Front Microbiol"},{"key":"5167_CR29","doi-asserted-by":"crossref","unstructured":"Heidrich CG, Mitova S, Schedlbauer A, Connell SR, Fucini P, Steenbergen JN et al (2016) The novel aminomethylcycline omadacycline has high specificity for the primary tetracycline-binding site on the bacterial ribosome[J]. Antibiot (Basel), 5(4):32","DOI":"10.3390\/antibiotics5040032"},{"issue":"1","key":"5167_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10409238309102789","volume":"14","author":"WV Shaw","year":"1983","unstructured":"Shaw WV (1983) Chloramphenicol acetyltransferase: Enzymology and molecular biology[J]. CRC Crit Rev Biochem 14(1):1\u201346","journal-title":"CRC Crit Rev Biochem"},{"issue":"7","key":"5167_CR31","doi-asserted-by":"publisher","first-page":"E1578","DOI":"10.1073\/pnas.1714645115","volume":"115","author":"YB Su","year":"2018","unstructured":"Su YB, Peng B, Li H, Cheng ZX, Zhang TT, Zhu JX et al (2018) Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria[J]. Proc Natl Acad Sci U S A 115(7):E1578\u2013e1587","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5167_CR32","doi-asserted-by":"publisher","first-page":"577564","DOI":"10.3389\/fmicb.2020.577564","volume":"11","author":"Y Liu","year":"2020","unstructured":"Liu Y, Yang K, Zhang H, Jia Y, Wang Z (2020) Combating antibiotic tolerance through activating bacterial metabolism[J]. Front Microbiol 11:577564","journal-title":"Front Microbiol"},{"issue":"1","key":"5167_CR33","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1038\/s41467-021-22649-4","volume":"12","author":"J Van Gestel","year":"2021","unstructured":"Van Gestel J, Bareia T, Tenennbaum B, Dal Co A, Guler P, Aframian N et al (2021) Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities[J]. Nat Commun 12(1):2324","journal-title":"Nat Commun"},{"issue":"2","key":"5167_CR34","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1093\/nar\/gkab1217","volume":"50","author":"JP Ramsay","year":"2022","unstructured":"Ramsay JP, Bastholm TR, Verdonk CJ, Tambalo DD, Sullivan JT, Harold LK et al (2022) An epigenetic switch activates bacterial quorum sensing and horizontal transfer of an integrative and conjugative element[J]. Nucleic Acids Res 50(2):975\u2013988","journal-title":"Nucleic Acids Res"}],"container-title":["Current Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-05167-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-05167-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00284-026-05167-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:41:25Z","timestamp":1793342485000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00284-026-05167-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["5167"],"URL":"https:\/\/doi.org\/10.1007\/s00284-026-05167-8","relation":{},"ISSN":["0343-8651","1432-0991"],"issn-type":[{"value":"0343-8651","type":"print"},{"value":"1432-0991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"assertion":[{"value":"10 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"573"}}