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This surge has prompted global research into new biologically active molecules, particularly those focused on combination therapies involving antifungal agents. Synthetic antimicrobial peptides have emerged as promising candidates to address this demand. Therefore, the objective of this study was to assess the synergistic therapeutic effects of the synthetic peptide \u03b3\n                    <jats:sub>31-45<\/jats:sub>\n                    <jats:italic>Pv<\/jats:italic>\n                    D\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>++<\/jats:sup>\n                    combined with amphotericin B (AmB) on\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    and\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    . This study aimed to identify the synergistic concentration that could facilitate advancement in the development of novel drugs. Here, we demonstrated that synergistic combinations of synthetic peptides and amphotericin B (AmB) effectively induce cell death in\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    and\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    . The checkerboard test revealed synergistic concentrations of 0.048 \u00b5M for AmB, 0.39 \u00b5M for the synthetic peptide \u03b3\n                    <jats:sub>31-45<\/jats:sub>\n                    <jats:italic>Pv<\/jats:italic>\n                    D\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>++<\/jats:sup>\n                    for\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    , 0.097 \u00b5M for AmB, and 0.78 \u00b5M for the synthetic peptide \u03b3\n                    <jats:sub>31-45<\/jats:sub>\n                    <jats:italic>Pv<\/jats:italic>\n                    D\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>++<\/jats:sup>\n                    for\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    . The mechanism of action underlying the death of these yeasts when exposed to these synergistic combinations involves several processes, including the loss of cell wall integrity, impairment of mitochondrial functionality, DNA condensation, and damage to cell morphology and ultrastructure. The data presented in this study will contribute significantly to the development of new therapies involving combinations of antifungal molecules.\n                  <\/jats:p>","DOI":"10.1007\/s00284-026-05197-2","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:52:44Z","timestamp":1792587164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Activity and Synergism of Amphotericin B and the Synthetic Bioinspired Peptide \u03b331-45PvD1++ Against Fungal Study Models Candida tropicalis and Saccharomyces cerevisiae"],"prefix":"10.1007","volume":"83","author":[{"given":"Thayn\u00e3 A. M.","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rica","family":"de O. 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