{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:28:15Z","timestamp":1789964895225,"version":"4.0.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000857","name":"Loughborough University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000857","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Math. Biol."],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00285-019-01371-2","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:47:01Z","timestamp":1560437221000},"page":"595-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mathematical modelling of contact dermatitis from nickel and chromium"],"prefix":"10.1007","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-2725","authenticated-orcid":false,"given":"J. P.","family":"Ward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Tindall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"issue":"11","key":"1371_CR1","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1182\/blood.V80.11.2920.2920","volume":"80","author":"M Brach","year":"1992","unstructured":"Brach M, deVos S, Gruss H, Herrmann F (1992) Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony stimulating factor is caused by inhibition of programmed cell death. Blood 80(11):2920\u20132924","journal-title":"Blood"},{"key":"1371_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1034\/j.1398-9995.2000.00107.x","volume":"55","author":"L Budinger","year":"2000","unstructured":"Budinger L, Hertl M (2000) Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview. Allergy 55:108\u2013115","journal-title":"Allergy"},{"key":"1371_CR3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1074-7613(00)80125-9","volume":"11","author":"R Callard","year":"1999","unstructured":"Callard R, George A, Stark J (1999) Cytokines, chaos, and complexity. Immunity 11:507\u2013513","journal-title":"Immunity"},{"issue":"6","key":"1371_CR4","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1046\/j.1365-2133.2000.03537.x","volume":"142","author":"N Cherry","year":"2000","unstructured":"Cherry N, Meyer J, Adisesh A, Brooke R, Owen-Smith V, Swales C, Beck M (2000) Surveillance of occupational skin disease: EPIDERM and OPRA. Brit J Derm 142(6):1128\u20131134","journal-title":"Brit J Derm"},{"issue":"5","key":"1371_CR5","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.tiv.2007.01.026","volume":"21","author":"A Curtis","year":"2007","unstructured":"Curtis A, Morton J, Balafa C, MacNeil S, Gawkrodger D, Warrem N, Evans G (2007) The effects of nickel and chromium on human keratinocytes: differences in viability, cell associated metal and IL-1alpha release. Toxicol In Vitro 21(5):809\u2013819","journal-title":"Toxicol In Vitro"},{"key":"1371_CR6","unstructured":"De\u00a0Craeker W, Roskams N, de\u00a0Beeck R (2008) Occupational skin diseases and dermal exposure in the european union (eu-25): policy and practice overview. European Agency for Safety and Health at Work"},{"key":"1371_CR7","doi-asserted-by":"crossref","unstructured":"Dominguez-H\u00fcttinger E, Christodoulides P, Miyauchi K, Irvine A, Okada-Hatakeyama M, Kubo M, Tanaka R (2017) Mathematical modeling of atopic dermatitis reveals \u201cdouble switch\u201d mechanisms underlying four common disease phenotypes. J Allergy Clin Immunol (in press)","DOI":"10.1016\/j.jaci.2016.10.026"},{"issue":"2","key":"1371_CR8","doi-asserted-by":"publisher","first-page":"20120090","DOI":"10.1098\/rsfs.2012.0090","volume":"3","author":"E Dominguez-H\u00fcttinger","year":"2013","unstructured":"Dominguez-H\u00fcttinger E, Ono M, Barahona M, Tanaka R (2013) Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasis. Interface Focus 3(2):20120090","journal-title":"Interface Focus"},{"key":"1371_CR9","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.tvjl.2012.06.047","volume":"193","author":"D D\u00f6pfer","year":"2012","unstructured":"D\u00f6pfer D, Holzhauer M, van Boven M (2012) The dynamics of digital dermatitis in populations of dairy cattle: model-based estimates of transition rates and implications for control. Vet J 193:648\u2013653","journal-title":"Vet J"},{"issue":"6","key":"1371_CR10","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1034\/j.1398-9995.1999.00882.x","volume":"54","author":"E Enrique","year":"1999","unstructured":"Enrique E, Garcia-Ortega P, Sotorra O, Graig P, Richart C (1999) Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis. Allergy 54(6):602\u2013606","journal-title":"Allergy"},{"issue":"4","key":"1371_CR11","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.tiv.2008.01.018","volume":"22","author":"S Franks","year":"2008","unstructured":"Franks S, Ward J, Tindall M, King J, Curtis A, Evans G (2008) A mathematical model to predict differences in keratinocyte responses to chromium and nickel. Toxicol In Vitro 22(4):1088\u20131093","journal-title":"Toxicol In Vitro"},{"issue":"1\u20132","key":"1371_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jim.2005.01.011","volume":"298","author":"V Ganusov","year":"2005","unstructured":"Ganusov V, Pilyugin S, de Boer R, Murali-Krishna K, Ahmed R, Antia R (2005) Quantifying cell turnover using CFSE data. J Immun Meth 298(1\u20132):183\u2013200","journal-title":"J Immun Meth"},{"key":"1371_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9435-9","volume-title":"Biochemistry of nickel","author":"R Hausinger","year":"1993","unstructured":"Hausinger R (1993) Biochemistry of nickel. Plenum Press, New York"},{"key":"1371_CR14","unstructured":"Health and Safety Executive (2017) Work-related skin disease in great Britain. HSE report \n                    www.hse.gov.uk\/statistics\/causdis\/dermatitis\/skin.pdf"},{"issue":"2","key":"1371_CR15","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.addr.2012.04.003","volume":"65","author":"O Jepps","year":"2013","unstructured":"Jepps O, Dancik Y, Anissimov Y, Roberts M (2013) Modeling the human skin barrier\u2014towards a better understanding of dermal absorption. Adv Drug Deliv Rev 65(2):152\u2013168","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"1371_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1053\/ajcd.2000.7186","volume":"11","author":"L Kanerva","year":"2000","unstructured":"Kanerva L, Jolanki R, Estlander T, Alanko K, Savlea A (2000) Incidence rates of occupational allergic contact dermatitis caused by metals. Am J Contact Dermat 11(3):155\u2013160","journal-title":"Am J Contact Dermat"},{"issue":"34","key":"1371_CR17","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1016\/j.vaccine.2007.05.046","volume":"25","author":"A Laurent","year":"2007","unstructured":"Laurent A, Mistretta F, Bottigioli D, Dahel K, Goujon C, Nicolas J, Hennino A, Laurent P (2007) Echographic measurement of skin thickness in adults by high frequency ultrasound to assess the appropriate microneedle length for intradermal delivery of vaccines. Vaccine 25(34):6423\u20136430","journal-title":"Vaccine"},{"key":"1371_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fcimb.2014.00177","volume":"4","author":"D Le","year":"2015","unstructured":"Le D, Miller J, Ganusov V (2015) Mathematical modeling provides kinetic details of the human immune response to vaccination. Front Cell Infect Microbiol 4:177","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"1371_CR19","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.bbrc.2004.05.029","volume":"319","author":"F Lin","year":"2004","unstructured":"Lin F, Nguyen C, Wang S, Saadi W, Gross S, Jeon N (2004) Effective neutrophil chemotaxis is strongly influenced by mean IL-8 concentration. Biochem Biophys Res Comm 319(2):576\u2013581","journal-title":"Biochem Biophys Res Comm"},{"issue":"2","key":"1371_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/imm.12500","volume":"146","author":"T Lorenzi","year":"2015","unstructured":"Lorenzi T, Chisholm R, Melensi M, Lorz A, Delitala M (2015) Mathematical model reveals how regulating the three phases of T-cell response could counteract immune evasion. Immunology 146(2):271\u2013280","journal-title":"Immunology"},{"key":"1371_CR21","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/ni1275","volume":"6","author":"A Luster","year":"2005","unstructured":"Luster A, Alon R, von Andrian U (2005) Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 6:1182\u20131190","journal-title":"Nat Immunol"},{"key":"1371_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.tiv.2013.10.013","volume":"28","author":"G Maxwell","year":"2014","unstructured":"Maxwell G, MacKay C, Cubberley R, Davies M, Gellatly N, Glavin S, Gouin T, Jacquoilleot S, Moore C, Pendlington R, Saib O, Sheffield D, Stark R, Summerfield V (2014) Applying the skin sensitisation adverse outcome pathway (aop) to quantitative risk assessment. Toxicol in Vitro 28:8\u201312","journal-title":"Toxicol in Vitro"},{"issue":"6670","key":"1371_CR23","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nature02238","volume":"427","author":"T Mempel","year":"2004","unstructured":"Mempel T, Henrickson S, von Andrian U (2004) T-cell priming by dendriticcells in lymph nodes occurs in three distinct phases. Nature 427(6670):154\u2013159","journal-title":"Nature"},{"issue":"6","key":"1371_CR24","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s11538-007-9197-x","volume":"69","author":"T Mollee","year":"2007","unstructured":"Mollee T, Bracken A (2007) A model of solute transport through stratum corneum using solute capture and release. Bull Math Biol 69(6):1887\u20131907","journal-title":"Bull Math Biol"},{"key":"1371_CR25","volume-title":"Perspectives in mammalian cell death","author":"J Moore","year":"1987","unstructured":"Moore J (1987) Death of cells and necrosis in tumour. In: Potten CS (ed) Perspectives in mammalian cell death. Oxford University Press, Oxford"},{"issue":"2","key":"1371_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.addr.2012.10.009","volume":"65","author":"A Naegel","year":"2013","unstructured":"Naegel A, Heisig M, Wittum G (2013) Detailed modelling of skin penetration\u2014an overview. Adv Drug Deliv Rev 65(2):191\u2013207","journal-title":"Adv Drug Deliv Rev"},{"key":"1371_CR27","doi-asserted-by":"publisher","first-page":"4739","DOI":"10.1093\/hmg\/ddv190","volume":"24","author":"E Ng","year":"2015","unstructured":"Ng E, Lind P, Lindgren C, Ingelsson E, Mahajan A, Morris A, Lind L (2015) Genome-wide association study of toxic metals and trace elements reveals novel associations. Hum Mol Genet 24:4739\u20134745","journal-title":"Hum Mol Genet"},{"issue":"1","key":"1371_CR28","first-page":"238","volume":"44","author":"L Nugent","year":"1984","unstructured":"Nugent L, Jain R (1984) Extravascular diffusion in normal and neoplastic tissues. Cancer Res 44(1):238\u2013244","journal-title":"Cancer Res"},{"key":"1371_CR29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1752-0509-7-95","volume":"7","author":"S Palsson","year":"2013","unstructured":"Palsson S, Hickling T, Bradshaw-Pierce E, Zager M, Jooss K, O\u2019Brien P, Spilker M, Palsson B, Vicini P (2013) The development of a fully-integrated immune response model (firm) simulator of the immune response through integration of multiple subset models. BMC Syst Biol 7:95","journal-title":"BMC Syst Biol"},{"issue":"6","key":"1371_CR30","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00542-002-0188-4","volume":"8","author":"L Pan","year":"2002","unstructured":"Pan L, Yuan P, Lin L (2002) 3D electroplated microstructures fabricated by a novel height control method. Microsyst Technol 8(6):391\u2013394","journal-title":"Microsyst Technol"},{"key":"1371_CR31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-0536.1979.tb05531.x","volume":"5","author":"L Peltonen","year":"1979","unstructured":"Peltonen L (1979) Nickel sensitivity in the general population. Contact Dermatol 5:27\u201332","journal-title":"Contact Dermatol"},{"issue":"7","key":"1371_CR32","first-page":"653","volume":"13","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Goebeler M (2015) Immunology of metal allergies. J Ger Soc Dermatol 13(7):653\u2013659","journal-title":"J Ger Soc Dermatol"},{"key":"1371_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-695X.2002.tb00596.x","volume":"34","author":"R Shrivastava","year":"2002","unstructured":"Shrivastava R, Upreti R, Seth P, Chaturvedi U (2002) Effects of chromium on the immune system. FEMS Immunol Med Microbiol 34:1\u20137","journal-title":"FEMS Immunol Med Microbiol"},{"key":"1371_CR34","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1046\/j.1523-1747.2003.12042.x","volume":"120","author":"P Stoitzner","year":"2003","unstructured":"Stoitzner P, Holzmann S, McLellan A, Ivarsson L, Stossel H, Kapp M, Kammerer U, Douillard P, Kampgen E, Koch F, Saeland S, Romani N (2003) Visualization and characterization of migratory langerhans cells in murine skin and lymph nodes by antibodies against langerin\/cd207. J Invest Dermatol 120:266\u2013274","journal-title":"J Invest Dermatol"},{"issue":"6","key":"1371_CR35","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/jid.2013.69","volume":"133","author":"R Tanaka","year":"2013","unstructured":"Tanaka R, Ono R (2013) Skin disease modeling from a mathematical perspective. J Invest Dermatol 133(6):1472\u20131478","journal-title":"J Invest Dermatol"},{"issue":"14","key":"1371_CR36","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.1021\/es0342704","volume":"38","author":"N Tantemsapya","year":"2004","unstructured":"Tantemsapya N, Meegoda J (2004) Estimation of diffusion coefficient of chromium in colloidal silica using digital photography. Environ Sci Technol 38(14):3950\u20133957","journal-title":"Environ Sci Technol"},{"issue":"18","key":"1371_CR37","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/0024-3205(96)00042-2","volume":"58","author":"I Williams","year":"1996","unstructured":"Williams I, Kupper T (1996) Immunity at the surface: homeostatic mechanisms of the skin immune system. Life Sci 58(18):1485\u20131507","journal-title":"Life Sci"},{"issue":"103","key":"1371_CR38","doi-asserted-by":"publisher","first-page":"UNSP 20141071","DOI":"10.1098\/rsif.2014.1071","volume":"12","author":"H Zhang","year":"2015","unstructured":"Zhang H, Hou W, Henrot L, Schnebert S, Dumas M, Heus\u00e8le C, Yang J (2015) Modelling epidermis homoeostasis and psoriasis pathogenesis. J R Soc Interface 12(103):UNSP 20141071","journal-title":"J R Soc Interface"}],"container-title":["Journal of Mathematical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00285-019-01371-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00285-019-01371-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00285-019-01371-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T23:11:00Z","timestamp":1591917060000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00285-019-01371-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["1371"],"URL":"https:\/\/doi.org\/10.1007\/s00285-019-01371-2","relation":{},"ISSN":["0303-6812","1432-1416"],"issn-type":[{"value":"0303-6812","type":"print"},{"value":"1432-1416","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"15 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}