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Math. Biol."],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer\u2019s disease progression. \n<\/jats:p>","DOI":"10.1007\/s00285-024-02179-5","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T08:09:33Z","timestamp":1738397373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A network aggregation model for amyloid-$$\\beta $$ dynamics and treatment of Alzheimer\u2019s diseases at the brain scale"],"prefix":"10.1007","volume":"90","author":[{"given":"Georgia S.","family":"Brennan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-8483","authenticated-orcid":false,"given":"Alain","family":"Goriely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"issue":"6\u20137","key":"2179_CR1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00285-012-0591-0","volume":"67","author":"Y Achdou","year":"2013","unstructured":"Achdou Y, Franchi B, Marcello N, Tesi MC (2013) A qualitative model for aggregation and diffusion of $$\\beta $$-amyloid in Alzheimer\u2019s disease. 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