{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:33:30Z","timestamp":1759581210531},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2011,9,11]],"date-time":"2011-09-11T00:00:00Z","timestamp":1315699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1007\/s00292-011-1517-0","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T17:47:55Z","timestamp":1315590475000},"page":"242-254","source":"Crossref","is-referenced-by-count":8,"title":["Pr\u00e4kanzerosen der Cervix uteri"],"prefix":"10.1007","volume":"32","author":[{"given":"L.-C.","family":"Horn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Klostermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,9,11]]},"reference":[{"key":"1517_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0090-8258(89)90001-2","volume":"35","author":"Andersen","year":"1989","unstructured":"Andersen ES, Arffmann E (1989) Adenocarcinoma in situ of the uterine cervix: a clinico-pathologic study of 36 cases. Gynecol Oncol 35(1):1\u20137","journal-title":"Gynecol Oncol"},{"key":"1517_CR2","unstructured":"Arbeitsgemeinschaft Zervixpathologie und Kolposkopie. http:\/\/www.dysplasiezentren.de\/2011"},{"key":"1517_CR3","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.jcv.2004.12.008","volume":"32","author":"Baseman","year":"2005","unstructured":"Baseman JG, Koutsky LA (2005) The epidemiology of human papillomavirus infections. J Clin Virol 32(Suppl 1):S16\u2013S24","journal-title":"J Clin Virol"},{"key":"1517_CR4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9378(87)80338-1","volume":"157","author":"Bertrand","year":"1987","unstructured":"Bertrand M, Lickrish GM, Colgan TJ (1987) The anatomic distribution of cervical adenocarcinoma in situ: implications for treatment. Am J Obstet Gynecol 157(1):21\u201325","journal-title":"Am J Obstet Gynecol"},{"key":"1517_CR5","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1471-0528.1976.tb00770.x","volume":"83","author":"Boddington","year":"1976","unstructured":"Boddington MM, Spriggs AI, Cowdell RH (1976) Adenocarcinoma of the uterine cervix: cytological evidence of a long preclinical evolution. Br J Obstet Gynaecol 83(11):900\u2013903","journal-title":"Br J Obstet Gynaecol"},{"key":"1517_CR6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/1097-0142(19810801)48:3<768::AID-CNCR2820480318>3.0.CO;2-L","volume":"48","author":"Boon","year":"1981","unstructured":"Boon ME, Baak JP, Kurver PJ et al (1981) Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. Cancer 48(3):768\u2013773","journal-title":"Cancer"},{"key":"1517_CR7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/0284186X.2011.555779","volume":"50","author":"Bulten","year":"2011","unstructured":"Bulten J, Horvat R, Jordan J et al (2011) European guidelines for quality assurance in cervical histopathology. Acta Oncol 50(5):611\u2013620 Epub 2011 Feb 11","journal-title":"Acta Oncol"},{"key":"1517_CR8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1365-2559.2002.01465.x","volume":"41","author":"Cameron","year":"2002","unstructured":"Cameron RI, Maxwell P, Jenkins D, McCluggage WG (2002) Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia. Histopathology 41(4):313\u2013321","journal-title":"Histopathology"},{"key":"1517_CR9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/pgp.0b013e31805152ab","volume":"26","author":"Carreon","year":"2007","unstructured":"Carreon JD, Sherman ME, Guill\u00e9n D et al (2007) CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples. Int J Gynecol Pathol 26(4):441\u2013446","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR10","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1086\/315498","volume":"181","author":"Carter","year":"2000","unstructured":"Carter JJ, Koutsky LA, Hughes JP et al (2000) Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection. J Infect Dis 181(6):1911\u20131919","journal-title":"J Infect Dis"},{"key":"1517_CR11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/gyno.1996.4528","volume":"64","author":"Casper","year":"1997","unstructured":"Casper GR, \u00d6st\u00f6r AG, Qiunn MA (1997) A clinicopathologic study of glandular dysplasia of the cervix. Gynecol Oncol 64:166\u2013170","journal-title":"Gynecol Oncol"},{"key":"1517_CR12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/pgp.0b013e31814fb1da","volume":"27","author":"Ceballos","year":"2008","unstructured":"Ceballos KM, Chapman W, Daya D et al (2008) Reproducibility of the histological diagnosis of cervical dysplasia among pathologists from 4 continents. Int J Gynecol Pathol 27(1):101\u2013107","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR13","first-page":"176","volume":"10","author":"Cina","year":"1997","unstructured":"Cina SJ, Richardson MS, Austin RM, Kurman RJ (1997) Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix. Mod Pathol 10(3):176\u2013180","journal-title":"Mod Pathol"},{"key":"1517_CR14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1158\/1055-9965.EPI-04-0812","volume":"14","author":"Clifford","year":"2005","unstructured":"Clifford GM, Rana RK, Franceschi S et al (2005) Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev 14(5):1157\u20131164","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1517_CR15","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0090-8258(90)90182-K","volume":"36","author":"Colgan","year":"1990","unstructured":"Colgan TJ, Lickrish GM (1990) The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. Gynecol Oncol 36(2):246\u2013249","journal-title":"Gynecol Oncol"},{"key":"1517_CR16","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1128\/JVI.00552-07","volume":"81","author":"Day","year":"2007","unstructured":"Day PM, Thompson CD, Buck CB et al (2007) Neutralization of human papillomavirus with monoclonal antibodies reveals different mechanisms of inhibition. J Virol 81(16):8784\u20138792 Epub Jun 6","journal-title":"J Virol"},{"key":"1517_CR17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7326\/0003-4819-148-7-200804010-00004","volume":"148","author":"Datta","year":"2008","unstructured":"Datta SD, Koutsky LA, Ratelle S et al (2008) Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003\u20132005. Ann Intern Med 148(7):493\u2013500","journal-title":"Ann Intern Med"},{"key":"1517_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0029-7844(97)00122-1","volume":"90","author":"Denehy","year":"1997","unstructured":"Denehy TR, Gregori CA, Breen JL (1997) Endocervical curettage, cone margins, and residual adenocarcinoma in situ of the cervix. Obstet Gynecol 90(1):1\u20136","journal-title":"Obstet Gynecol"},{"key":"1517_CR19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/00313020500058607","volume":"37","author":"Dray","year":"2005","unstructured":"Dray M, Russell P, Dalrymple C et al (2005) p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology 37(2):112\u2013124","journal-title":"Pathology"},{"key":"1517_CR20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/pgp.0b013e318038154d","volume":"26","author":"Fadare","year":"2007","unstructured":"Fadare O, Rodriguez R (2007) Squamous dysplasia of the uterine cervix: tissue sampling-related diagnostic considerations in 600 consecutive biopsies. Int J Gynecol Pathol 26(4):469\u2013474","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR21","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/modpathol.3800935","volume":"20","author":"Fadare","year":"2007","unstructured":"Fadare O, Yi X, Liang SX et al (2007) Variations of mitotic index in normal and dysplastic squamous epithelium of the uterine cervix as a function of endometrial maturation. Mod Pathol 20(9):1000\u20131008 Epub Jul 20","journal-title":"Mod Pathol"},{"key":"1517_CR22","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/jnci\/84.13.1030","volume":"84","author":"Friedell","year":"1992","unstructured":"Friedell GH, Tucker TC, McManmon E et al (1992) Incidence of dysplasia and carcinoma of the uterine cervix in an Appalachian population. J Natl Cancer Inst 84:1030\u20131032","journal-title":"J Natl Cancer Inst"},{"key":"1517_CR23","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/1097-0142(19860915)58:6<1272::AID-CNCR2820580616>3.0.CO;2-B","volume":"58","author":"Gloor","year":"1986","unstructured":"Gloor E, Hurlimann J (1986) Cervical intraepithelial glandular neoplasia (adenocarcinoma in situ and glandular dysplasia). A correlative study of 23 cases with histologic grading, histochemical analysis of mucins and immunohistochemical determination of the affinity for four lectins. Cancer 58:1272\u20131280","journal-title":"Cancer"},{"key":"1517_CR24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ajcp\/110.2.200","volume":"110","author":"Goldstein","year":"1998","unstructured":"Goldstein NS, Ahmad E, Hussain M et al (1998) Endocervical glandular atypia does preneoplastic lesion of adenocarcinoma in situ exist? Am J Clin Pathol 110:200\u2013209","journal-title":"Am J Clin Pathol"},{"key":"1517_CR25","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ajcp\/110.2.200","volume":"110","author":"Goldstein","year":"1998","unstructured":"Goldstein NS, Ahmad E, Hussain M et al (1998) Endocervical glandular atypia does preneoplastic lesion of adenocarcinoma in situ exist? Am J Clin Pathol 110:200\u2013209","journal-title":"Am J Clin Pathol"},{"key":"1517_CR26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00004347-199904000-00005","volume":"18","author":"Harnden","year":"1999","unstructured":"Harnden P, Kennedy W, Andrew AC, Southgate J (1999) Immunophenotype of transitional metaplasia of the uterine cervix. Int J Gynecol Pathol 18(2):125\u2013129","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR27","first-page":"78","volume":"30","author":"Hilfrich","year":"2008","unstructured":"Hilfrich R, Hariri J (2008) Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker. Anal Quant Cytol Histol 30(2):78\u201382","journal-title":"Anal Quant Cytol Histol"},{"key":"1517_CR28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jnci\/91.3.252","volume":"91","author":"Holowaty","year":"1999","unstructured":"Holowaty P, Miller AB, Rohan T, To T (1999) Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst 91(3):252\u2013258","journal-title":"J Natl Cancer Inst"},{"key":"1517_CR29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00292-006-0845-y","volume":"28","author":"Horn","year":"2007","unstructured":"Horn LC, Einenkel J, H\u00f6ckel M et al (2007) Pathoanatomical preparation and reporting for dysplasias and cancers of the cervix uteri: cervical biopsy, conization, radical hysterectomy and exenteration. Pathologe 28(4):249\u2013260","journal-title":"Pathologe"},{"key":"1517_CR30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/PAS.0b013e31815ac420","volume":"32","author":"Horn","year":"2008","unstructured":"Horn LC, Reichert A, Oster A et al (2008) Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 32(4):502\u2013512","journal-title":"Am J Surg Pathol"},{"key":"1517_CR31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00004347-200301000-00005","volume":"22","author":"Ioffe","year":"2003","unstructured":"Ioffe OB, Sagae S, Moritani S et al (2003) Symposium part 3: Should pathologists diagnose endocervical preneoplastic lesions \u201eless than\u201c adenocarcinoma in situ?: Point. Int J Gynecol Pathol 22(1):18\u201321","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR32","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/1097-0142(19880315)61:6<1171::AID-CNCR2820610620>3.0.CO;2-X","volume":"61","author":"Jaworski","year":"1988","unstructured":"Jaworski RC, Pacey NF, Greenberg ML, Osborn RA (1988) The histologic diagnosis of adenocarcinoma in situ and related lesions of the cervix uteri. Adenocarcinoma in situ. Cancer 61(6):1171\u20131181","journal-title":"Cancer"},{"key":"1517_CR33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00125480-199803000-00005","volume":"5","author":"Jones","year":"1998","unstructured":"Jones MA (1998) Transitional cell metaplasia and neoplasia in the female genital tract: an update. Adv Anat Pathol 5(2):106\u2013113","journal-title":"Adv Anat Pathol"},{"key":"1517_CR34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00007435-199205000-00009","volume":"19","author":"Kataja","year":"1992","unstructured":"Kataja V, Syrj\u00e4nen S, M\u00e4ntyj\u00e4rvi R et al (1992) Prognostic factors in cervical human papillomavirus infections. Sex Transm Dis 19(3):154\u2013160","journal-title":"Sex Transm Dis"},{"key":"1517_CR35","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.93.9.4350","volume":"93","author":"Khleif","year":"1996","unstructured":"Khleif SN, DeGregori J, Yee CL et al (1996) Inhibition of cyclin D-CDK4\/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A 93(9):4350\u20134354","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1517_CR36","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00000478-200211000-00001","volume":"26","author":"Klaes","year":"2002","unstructured":"Klaes R, Benner A, Friedrich T et al (2002) p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26(11):1389\u20131399","journal-title":"Am J Surg Pathol"},{"key":"1517_CR37","first-page":"6132","volume":"59","author":"Klaes","year":"1999","unstructured":"Klaes R, Woerner SM, Ridder R et al (1999) Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 59(24):6132\u20136136","journal-title":"Cancer Res"},{"key":"1517_CR38","first-page":"125","volume":"48","author":"Kolstad","year":"1976","unstructured":"Kolstad P, Klem V (1976) Long-term followup of 1121 cases of carcinoma in situ. Obstet Gynecol 48(2):125\u2013129","journal-title":"Obstet Gynecol"},{"key":"1517_CR39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0002-9343(97)00177-0","volume":"102","author":"Koutsky","year":"1997","unstructured":"Koutsky L (1997) Epidemiology of genital human papillomavirus infection. Am J Med 102(5A):3\u20138","journal-title":"Am J Med"},{"key":"1517_CR40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jcp.52.2.112","volume":"52","author":"Kurian","year":"1999","unstructured":"Kurian K, al-Nafussi A (1999) Relation of cervical glandular intraepithelial neoplasia to microinvasive and invasive adenocarcinoma of the uterine cervix: a study of 121 cases. J Clin Pathol 52(2):112\u2013117","journal-title":"J Clin Pathol"},{"key":"1517_CR41","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/1097-0142(20000901)89:5<1048::AID-CNCR14>3.0.CO;2-S","volume":"89","author":"Lee","year":"2000","unstructured":"Lee KR, Flynn CE (2000) Early invasive adenocarcinoma of the cervix. Cancer 89(5):1048\u20131055","journal-title":"Cancer"},{"key":"1517_CR42","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1053\/hupa.2000.7644","volume":"31","author":"Lee","year":"2000","unstructured":"Lee KR, Sun D, Crum CP (2000) Endocervical intraepithelial glandular atypia (dysplasia): A histopathologic, human papillomavirus, and MIB-1 analysis of 25 cases. Hum Pathol 31(6):656\u2013664","journal-title":"Hum Pathol"},{"key":"1517_CR43","unstructured":"L\u00f6ning T, Riethdorf l (2011) Die Differenzialdiagnose des Adenokarzinoms der Zervix. Im Druck"},{"key":"1517_CR44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00004347-199904000-00002","volume":"18","author":"Lu","year":"1999","unstructured":"Lu X, Shiozawa T, Nakayama K et al (1999) Abnormal expression of sex steroid receptors and cell cycle-related molecules in adenocarcinoma in situ of the uterine cervix. Int J Gynecol Pathol 18(2):109\u2013114","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/PGP.0b013e318181b41c","volume":"28","author":"Macedo","year":"2009","unstructured":"Macedo FC de, Nicol AF, Scudeler D, Nuovo GJ (2009) The utility of HPV in situ hybridization and the PAS test in improving the specificity of the diagnosis of CIN 1. Int J Gynecol Pathol 28(1):83\u201389","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR46","first-page":"361","volume":"56","author":"Maier","year":"1980","unstructured":"Maier RC, Norris HJ (1980) Coexistence of cervical intraepithelial neoplasia with primary adenocarcinoma of the endocervix. Obstet Gynecol 56(3):361\u2013364","journal-title":"Obstet Gynecol"},{"key":"1517_CR47","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.ygyno.2005.07.040","volume":"99","author":"Malpica","year":"2005","unstructured":"Malpica A, Matisic JP, Niekirk DV et al (2005) Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issues. Gynecol Oncol 99(3 Suppl 1):S38\u2013S52","journal-title":"Gynecol Oncol"},{"key":"1517_CR48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00004347-199701000-00004","volume":"16","author":"McCluggage","year":"1997","unstructured":"McCluggage G, McBride H, Maxwell P, Bharucha H (1997) Immunohistochemical detection of p53 and bcl-2 proteins in neoplastic and non-neoplastic endocervical glandular lesions. Int J Gynecol Pathol 16(1):22\u201327","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/pgp.0b013e31815698e7","volume":"27","author":"McCluggage","year":"2008","unstructured":"McCluggage WG, Shah R, Connolly LE, McBride HA (2008) Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. Int J Gynecol Pathol 27(1):92\u2013100","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1479-828X.2010.01170.x","volume":"50","author":"McCredie","year":"2010","unstructured":"McCredie MR, Paul C, Sharples KJ et al (2010) Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. Aust N Z J Obstet Gynaecol 50(4):363\u2013370","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"1517_CR51","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","volume":"9","author":"McCredie","year":"2008","unstructured":"McCredie MR, Sharples KJ, Paul C et al (2008) Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol 9(5):425\u2013434","journal-title":"Lancet Oncol"},{"key":"1517_CR52","first-page":"451","volume":"64","author":"McIndoe","year":"1984","unstructured":"McIndoe WA, McLean MR, Jones RW, Mullins PR (1984) The invasive potential of carcinoma in situ of the cervix. Obstet Gynecol 64(4):451\u2013458","journal-title":"Obstet Gynecol"},{"key":"1517_CR53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5858\/134.3.393","volume":"34","author":"Medeiros","year":"2010","unstructured":"Medeiros F, Bell DA (2010) Pseudoneoplastic lesions of the female genital tract. Arch Pathol Lab Med 34(3):393\u2013403","journal-title":"Arch Pathol Lab Med"},{"key":"1517_CR54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/LGT.0b013e31817ff940","volume":"13","author":"Miroshnichenko","year":"2009","unstructured":"Miroshnichenko GG, Parva M, Holtz DO et al (2009) Interpretability of excisional biopsies of the cervix: cone biopsy and loop excision. J Low Genit Tract Dis 13(1):10\u201312","journal-title":"J Low Genit Tract Dis"},{"key":"1517_CR55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ygyno.2005.07.108","volume":"100","author":"Molden","year":"2006","unstructured":"Molden T, Kraus I, Karlsen F et al (2006) Human papillomavirus E6\/E7 mRNA expression in women younger than 30\u00a0years of age. Gynecol Oncol 100(1):95\u2013100","journal-title":"Gynecol Oncol"},{"key":"1517_CR56","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1525-1438.2006.00374.x","volume":"16","author":"Moreira","year":"2006","unstructured":"Moreira MA, Longato-Filho A, Taromaru E et al (2006) Investigation of human papillomavirus by hybrid capture II in cervical carcinomas including 113 adenocarcinomas and related lesions. Int J Gynecol Cancer 16(2):586\u2013590","journal-title":"Int J Gynecol Cancer"},{"key":"1517_CR57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00004347-200204000-00004","volume":"21","author":"Moritani","year":"2002","unstructured":"Moritani S, Ioffe OB, Sagae S et al (2002) Mitotic activity and apoptosis in endocervical glandular lesions. Int J Gynecol Pathol 21(2):125\u2013133","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR58","doi-asserted-by":"crossref","first-page":"d641","DOI":"10.2741\/munger","volume":"7","author":"M\u00fcnger","year":"2002","unstructured":"M\u00fcnger K (2002) The role of human papillomaviruses in human cancers. Front Biosci 7:d641\u2013d649","journal-title":"Front Biosci"},{"key":"1517_CR59","first-page":"609","volume":"61","author":"Nasiell","year":"1983","unstructured":"Nasiell K, Nasiell M, Va\u0107lavinkov\u00e1 V (1983) Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 61(5):609\u2013614","journal-title":"Obstet Gynecol"},{"key":"1517_CR60","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00006250-198605000-00012","volume":"67","author":"Nasiell","year":"1986","unstructured":"Nasiell K, Roger V, Nasiell M (1986) Behavior of mild cervical dysplasia during long-term follow-up. Obstet Gynecol 67(5):665\u2013669","journal-title":"Obstet Gynecol"},{"key":"1517_CR61","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/PGP.0b013e31820a79b0","volume":"30","author":"Negri","year":"2011","unstructured":"Negri G, Bellisano G, Carico E et al (2011) Usefulness of p16ink4a, ProEX C, and Ki-67 for the diagnosis of glandular dysplasia and adenocarcinoma of the cervix uteri. Int J Gynecol Pathol 30(4):407\u2013413","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR62","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/PAS.0b013e3181709fbf","volume":"32","author":"Negri","year":"2008","unstructured":"Negri G, Bellisano G, Zannoni GF et al (2008) p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri. Am J Surg Pathol 32(11):1715\u20131720","journal-title":"Am J Surg Pathol"},{"key":"1517_CR63","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/jcp.2005.030726","volume":"59","author":"Negri","year":"2006","unstructured":"Negri G, Moretto G, Menia E et al (2006) Immunocytochemistry of p16INK4a in liquid-based cervicovaginal specimens with modified Papanicolaou counterstaining. J Clin Pathol 59(8):827\u2013830","journal-title":"J Clin Pathol"},{"key":"1517_CR64","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/00000478-199908000-00005","volume":"23","author":"Nucci","year":"1999","unstructured":"Nucci MR, Clement PB, Young RE (1999) Lobular endocervical glandular hyperplasia, not otherwise specified. Am J Surg Pathol 23:886\u2013891","journal-title":"Am J Surg Pathol"},{"key":"1517_CR65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.pap.0000201828.92719.f3","volume":"13","author":"O","year":"2006","unstructured":"O\u2019Neill CJ, McCluggage WG (2006) p16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol 13(1):8\u201315","journal-title":"Adv Anat Pathol"},{"key":"1517_CR66","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00004347-199304000-00018","volume":"12","author":"\u00d6st\u00f6r","year":"1993","unstructured":"\u00d6st\u00f6r AG (1993) Natural history of cervical intraepithelial neoplasia \u2013 a critical review. Int J Gynecol Pathol 12:186\u2013192","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00001703-199602000-00015","volume":"8","author":"\u00d6st\u00f6r","year":"1996","unstructured":"\u00d6st\u00f6r AG, Mulvany N (1996) The pathology of cervical neoplasia. Curr Opin Obstet Gynecol 8:69\u201373","journal-title":"Curr Opin Obstet Gynecol"},{"key":"1517_CR68","doi-asserted-by":"crossref","unstructured":"Papanicolaou GN, Traut HF (1943) Diagnosis of uterine cancer by the vaginal smear. Commonwealth Fund, New York","DOI":"10.1097\/00000441-194312000-00020"},{"key":"1517_CR69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0029-7844(02)02058-6","volume":"100","author":"Parker","year":"2002","unstructured":"Parker MF, Zahn CM, Vogel KM et al (2002) Discrepancy in the interpretation of cervical histology by gynecologic pathologists. Obstet Gynecol 100(2):277\u2013280","journal-title":"Obstet Gynecol"},{"key":"1517_CR70","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ygyno.2009.10.055","volume":"116","author":"Pavlakis","year":"2010","unstructured":"Pavlakis K, Messini I, Yiannou P et al (2010) A pre-tailored panel of antibodies in the study of cervical mesonephric remnants. Gynecol Oncol 116(3):468\u2013472","journal-title":"Gynecol Oncol"},{"key":"1517_CR71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/gyno.1999.5524","volume":"75","author":"Plaxe","year":"1999","unstructured":"Plaxe SC, Saltzstein SL (1999) Estimation of the duration of the preclinical phase of cervical adenocarcinoma suggests that there is ample opportunity for screening. Gynecol Oncol 75(1):55\u201361","journal-title":"Gynecol Oncol"},{"key":"1517_CR72","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ygyno.2010.02.003","volume":"117","author":"Quint","year":"2010","unstructured":"Quint KD, Koning MN de, Doorn LJ van et al (2010) HPV genotyping and HPV16 variant analysis in glandular and squamous neoplastic lesions of the uterine cervix. Gynecol Oncol 117(2):297\u2013301","journal-title":"Gynecol Oncol"},{"key":"1517_CR73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/PAS.0b013e3181c89c98","volume":"34","author":"Rabban","year":"2010","unstructured":"Rabban JT, McAlhany S, Lerwill MF et al (2010) PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. Am J Surg Pathol 34(2):137\u2013146","journal-title":"Am J Surg Pathol"},{"key":"1517_CR74","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1097-0142(195603\/04)9:2<385::AID-CNCR2820090225>3.0.CO;2-I","volume":"9","author":"Reagan","year":"1956","unstructured":"Reagan JW, Harmonic MJ (1956) The cellular pathology in carcinoma in situ: a cytohistopathological correlation. Cancer 9:385","journal-title":"Cancer"},{"key":"1517_CR75","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1749-6632.1962.tb34677.x","volume":"97","author":"Reagan","year":"1962","unstructured":"Reagan JW, Patten SF Jr (1962) Dysplasia: a basic reaction to injury in the uterine cervix. Ann N Y Acad Sci 97:662\u2013682","journal-title":"Ann N Y Acad Sci"},{"key":"1517_CR76","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2559.2007.02652.x","volume":"50","author":"Regauer","year":"2007","unstructured":"Regauer S, Reich O (2007) CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology 50(5):629\u2013635","journal-title":"Histopathology"},{"key":"1517_CR77","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/PGP.0b013e3181fde259","volume":"30","author":"Ribeiro","year":"2011","unstructured":"Ribeiro AA, Figueiredo Alves RR, Costa MC et al (2011) Association between HPV types and species groups and cervical neoplasia from a high-risk area for cervical cancer, Goi\u00e2nia, Brazil. Int J Gynecol Pathol 30(3):288\u2013294","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR78","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/1097-0142(196603)19:3<395::AID-CNCR2820190313>3.0.CO;2-O","volume":"19","author":"Richart","year":"1966","unstructured":"Richart RM (1966) Colpomicroscopic studies of cervical intraepithelial neoplasia. Cancer 19:395","journal-title":"Cancer"},{"key":"1517_CR79","first-page":"301","volume":"8","author":"Richart","year":"1973","unstructured":"Richart RM (1973) Cervical intraepithelial neoplasia. Pathol Annu 8:301\u2013328","journal-title":"Pathol Annu"},{"key":"1517_CR80","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm1598","volume":"13","author":"Roberts","year":"2007","unstructured":"Roberts JN, Buck CB, Thompson CD et al (2007) Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan. Nat Med 13(7):857\u2013861","journal-title":"Nat Med"},{"key":"1517_CR81","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1016\/j.jgyn.2007.11.017","volume":"Reprod","author":"Rouzier","year":"2008","unstructured":"Rouzier R (2008) Management of CIN1. J Gynecol Obstet Biol Reprod (Paris) 37(Suppl 1):S114\u2013S120","journal-title":"J Gynecol Obstet Biol"},{"key":"1517_CR82","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0002-9440(10)65689-1","volume":"153","author":"Sano","year":"1998","unstructured":"Sano T, Oyama T, Kashiwabara K et al (1998) Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153(6):1741\u20131748","journal-title":"Am J Pathol"},{"key":"1517_CR83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004347-199901000-00001","volume":"18","author":"Schlesinger","year":"1999","unstructured":"Schlesinger C, Silverberg SG (1999) Endocervical adenocarcinoma in situ of tubal type and its relation to atypical tubal metaplasia. Int J Gynecol Pathol 18(1):1\u20134","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR84","doi-asserted-by":"crossref","unstructured":"Schmidt D (2011) Der Einsatz von Biomarkern in der zytologischen Diagnostik der pr\u00e4kanzer\u00f6sen Ver\u00e4nderungen der Zervix. Im Druck","DOI":"10.1007\/s00292-011-1478-3"},{"key":"1517_CR85","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/cncr.10886","volume":"96","author":"Schoolland","year":"2002","unstructured":"Schoolland M, Segal A, Allpress S et al (2002) Adenocarcinoma in situ of the cervix. Cancer 96(6):330\u2013337","journal-title":"Cancer"},{"key":"1517_CR86","unstructured":"Schottl\u00e4nder J, Kermauner F (1912) Zur Kenntnis des Uteruskarzinoms; monographische Studie \u00fcber Morphologie, Entwicklung, Wachstum, nebst Beitr\u00e4gen zur Klinik der Erkrankung. Karger, Berlin"},{"key":"1517_CR87","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1447-0756.2008.00834.x","volume":"35","author":"Shin","year":"2009","unstructured":"Shin JW, Rho HS, Park CY (2009) Factors influencing the choice between cold knife conization and loop electrosurgical excisional procedure for the treatment of cervical intraepithelial neoplasia. J Obstet Gynaecol Res 35(1):126\u2013130","journal-title":"J Obstet Gynaecol Res"},{"key":"1517_CR88","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/PGP.0b013e3181cd3175","volume":"29","author":"Smedts","year":"2010","unstructured":"Smedts F, Ramaekers FC, Hopman AH (2010) The two faces of cervical adenocarcinoma in situ. Int J Gynecol Pathol 29(4):378\u2013385","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR89","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.22527","volume":"121","author":"Smith","year":"2007","unstructured":"Smith JS, Lindsay L, Hoots B et al (2007) Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer 121(3):621\u2013632","journal-title":"Int J Cancer"},{"key":"1517_CR90","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.12.951-a","volume":"93","author":"Solomon","year":"2001","unstructured":"Solomon D, Schiffman M, Tarone R, ALTS Study group (2001) Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: Baseline results from a randomized trial. J Natl Cancer Inst 93(4):293\u2013299","journal-title":"J Natl Cancer Inst"},{"key":"1517_CR91","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/ijc.21604","volume":"118","author":"Soutter","year":"2006","unstructured":"Soutter WP, Sasieni P, Panoskaltsis T (2006) Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia. Int J Cancer 118(8):2048\u20132055","journal-title":"Int J Cancer"},{"key":"1517_CR92","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ygyno.2010.01.024","volume":"117","author":"Stanley","year":"2010","unstructured":"Stanley M (2010) Pathology and epidemiology of HPV infection in females. Gynecol Oncol 117(Suppl 2):5\u201310","journal-title":"Gynecol Oncol"},{"key":"1517_CR93","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/00313021003631353","volume":"42","author":"Stewart","year":"2010","unstructured":"Stewart CJ, Little L (2010) Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium. Pathology 42(3):217\u2013223","journal-title":"Pathology"},{"key":"1517_CR94","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02505329","volume":"259","author":"Teshima","year":"1997","unstructured":"Teshima H, Beaudenon S, Koi S et al (1997) Human papillomavirus type 18 sequences in adenocarcinoma and adenosquamous carcinoma of the uterine cervix. Arch Gynecol Obstet 259:169\u2013177","journal-title":"Arch Gynecol Obstet"},{"key":"1517_CR95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00292-005-0763-4","volume":"26","author":"Trunk","year":"2005","unstructured":"Trunk MJ, Wentzensen N, Knebel Doeberitz M von (2005) Molekulare Pathogenese des Zervixkarzinoms und seiner Vorstufen. Pathologe 26(4):283\u2013290","journal-title":"Pathologe"},{"key":"1517_CR96","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ctrv.2008.10.005","volume":"35","author":"Tsoumpou","year":"2009","unstructured":"Tsoumpou I, Arbyn M, Kyrgiou M et al (2009) p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev 35(3):210\u2013220","journal-title":"Cancer Treat Rev"},{"key":"1517_CR97","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/cncr.20474","volume":"102","author":"Aspert-van","year":"2004","unstructured":"Aspert-van Erp AJ van, Smedts FM, Vooijs GP (2004) Severe cervical glandular cell lesions with coexisting squamous cell lesions. Cancer 102(4):218\u2013227","journal-title":"Cancer"},{"key":"1517_CR98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00004347-199701000-00003","volume":"16","author":"Hoeven","year":"1997","unstructured":"Hoeven KH van, Ramondetta L, Kovatich AJ et al (1997) Quantitative image analysis of MIB-1 reactivity in inflammatory, hyperplastic, and neoplastic endocervical lesions. Int J Gynecol Pathol 16(1):15\u201321","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR99","unstructured":"Volante R, Giubilato P, Ronco G (2010) Quality of colposcopy and treatment: data from the national survey of Italian organised cervical screening programmes. 2008 activity. Epidemiol Prev 34(5\u20136 Suppl 4):73\u201380"},{"key":"1517_CR100","unstructured":"Knebel-Doeberitz M von (2011) Pathogenese HPV-assoziierter Neoplasien. Im Druck"},{"key":"1517_CR101","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","volume":"189","author":"Walboomers","year":"1999","unstructured":"Walboomers JM, Jacobs MV, Manos MM et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189(1):12\u201319","journal-title":"J Pathol"},{"key":"1517_CR102","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/cncr.20064","volume":"100","author":"Wang","year":"2004","unstructured":"Wang SS, Sherman ME, Hildesheim A et al (2004) Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976\u20132000. Cancer 100(5):1035\u20131044","journal-title":"Cancer"},{"key":"1517_CR103","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ygyno.2006.03.049","volume":"103","author":"Wang","year":"2006","unstructured":"Wang SS, Sherman ME, Silverberg SG et al (2006) Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study. Gynecol Oncol 103(2):541\u2013546","journal-title":"Gynecol Oncol"},{"key":"1517_CR104","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00000478-199705000-00002","volume":"21","author":"Weir","year":"1997","unstructured":"Weir MM, Bell DA, Young RH (1997) Transitional cell metaplasia of the uterine cervix and vagina: an underrecognized lesion that may be confused with high-grade dysplasia. A report of 59 cases. Am J Surg Pathol 21(5):510\u2013517","journal-title":"Am J Surg Pathol"},{"key":"1517_CR105","unstructured":"Wells M, \u00d6st\u00f6r AG, Crum CP et al (2003) Epithelial tumors of the aauterine cervix. In: Tavassoli FA, Devilee P (eds) Pathology and genetics of tumours of the breast and female genital organs. World Health Organization Classification of Tumours. IARC Press, Lyon, pp 259\u2013279"},{"key":"1517_CR106","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/01.pas.0000173239.24955.a2","volume":"29","author":"Witkiewicz","year":"2005","unstructured":"Witkiewicz A, Lee KR, Brodsky G et al (2005) Superficial (early) endocervical adenocarcinoma in situ: a study of 12 cases and comparison to conventional AIS. Am J Surg Pathol 29(12):1609\u20131614","journal-title":"Am J Surg Pathol"},{"key":"1517_CR107","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(03)12120-4","volume":"361","author":"Woodman","year":"2003","unstructured":"Woodman CB, Collins S, Rollason TP et al (2003) Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia. Lancet 361(9351):40\u201343","journal-title":"Lancet"},{"key":"1517_CR108","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00004347-200210000-00002","volume":"21","author":"Zaino","year":"2002","unstructured":"Zaino RJ (2002) Symposium part I: Adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcinoma of the uterine cervix. Int J Gynecol Pathol 21(4):314\u2013326","journal-title":"Int J Gynecol Pathol"},{"key":"1517_CR109","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","volume":"2","author":"Hausen","year":"2002","unstructured":"Hausen H zur (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2(5):342\u2013350","journal-title":"Nat Rev Cancer"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-011-1517-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-011-1517-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-011-1517-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T03:14:36Z","timestamp":1638587676000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-011-1517-0"}},"subtitle":["Morphologie und Molekularpathologie"],"short-title":[],"issued":{"date-parts":[[2011,9,11]]},"references-count":109,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["1517"],"URL":"https:\/\/doi.org\/10.1007\/s00292-011-1517-0","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,11]]}}}