{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:33:56Z","timestamp":1757702036790},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Aufgrund verschiedener Muster molekularer Ver\u00e4nderungen wird heute von einem dualistischen Modell der ser\u00f6sen Tumoren ausgegangen, wobei ser\u00f6se Borderlinetumoren (SBT) und ser\u00f6se Low-grade-Karzinome (LGSC) auf der einen Seite von ser\u00f6sen High-grade-Karzinomen (HGSC) auf der anderen Seite unterschieden werden. Der klinische Verlauf und die Art der Therapie von SBT und LGSC h\u00e4ngen entscheidend davon, ob sie mit extraovariellen Manifestationen einhergehen. Sogenannte invasive Implants von SBT entsprechen morphologisch dem Bild eines LGSC. F\u00fcr die Unterscheidung von LGSC und HGSC hat sich das M.D.-Anderson-Gradingsystem etabliert. HGSC weisen ein breites Spektrum an Wachstumsmustern auf, zu dem auch ein transitionalepithel\u00e4hnlicher Typ geh\u00f6rt. Karzinosarkome sind ebenfalls als HGSC-Variante zu interpretieren. Die neue Theorie, nach der sich alle ser\u00f6sen Neoplasien des Ovars, Peritoneums und der Tube von den Tubenfimbrien ableiten, l\u00e4sst die Bezeichnung \u201eOvarialkarzinom\u201c als nicht mehr angemessen erscheinen.<\/jats:p>","DOI":"10.1007\/s00292-014-1906-2","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T07:32:58Z","timestamp":1402471978000},"page":"314-321","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ser\u00f6se Tumoren des Ovars"],"prefix":"10.1007","volume":"35","author":[{"given":"J.","family":"Diebold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"1906_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/PGP.0b013e31827630eb","volume":"32","author":"Ali","year":"2013","unstructured":"Ali RH, Kalloger SE, Santos JL et al (2013) Stage II to IV low-grade serous carcinoma of the ovary is associated with a poor prognosis: a clinicopathologic study of 32 patients from a population-based tumor registry. 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