{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:48:09Z","timestamp":1778798889471,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00292-016-0159-7","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T09:21:53Z","timestamp":1461144113000},"page":"253-257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polyglandul\u00e4re autoimmune Syndrome","Polyglandular autoimmune syndromes"],"prefix":"10.1007","volume":"37","author":[{"given":"P.","family":"Komminoth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"159_CR1","first-page":"\u25a0","volume":"\u25a0","author":"S Barkia Beradhi","year":"2015","unstructured":"Barkia Beradhi S, Flesch BK, Hansen MP et\u00a0al (2015) HLA class II differentiates between thyroid and polyglandular autoimmunity. Horm Metab Res : (Epub ahead of print)","journal-title":"Horm Metab Res"},{"key":"159_CR2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MED.0b013e32836313eb","volume":"20","author":"MH Cheng","year":"2013","unstructured":"Cheng MH, Anderson MS (2013) Insights into type 1 diabetes from the autoimmune polyendocrine syndromes. Curr Opin Endocrinol Diabetes Obes 20:271\u2013278","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"159_CR3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.autrev.2013.07.006","volume":"13","author":"M Cutolo","year":"2014","unstructured":"Cutolo M (2014) Autoimmune polyendocrine syndromes. Autoimmun Rev 13:85\u201389","journal-title":"Autoimmun Rev"},{"key":"159_CR4","doi-asserted-by":"crossref","first-page":"E177","DOI":"10.1210\/jc.2013-2852","volume":"99","author":"BK Flesch","year":"2014","unstructured":"Flesch BK, Matheis N, Alt T et\u00a0al (2014) HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III. J\u00a0Clin Endocrinol Metab 99:E177\u2013182","journal-title":"J Clin Endocrinol Metab"},{"key":"159_CR5","doi-asserted-by":"crossref","first-page":"e1720","DOI":"10.1542\/peds.2013-3308","volume":"134","author":"M Geyer","year":"2014","unstructured":"Geyer M, Fairchild J, Moore D et\u00a0al (2014) Recalcitrant hypocalcaemia in autoimmune enteropathy. Pediatrics 134:e1720\u20131726","journal-title":"Pediatrics"},{"key":"159_CR6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-0032-1327355","volume":"138","author":"MP Hansen","year":"2013","unstructured":"Hansen MP, Kahaly GJ (2013) Autoimmune polyglandular syndromes. Dtsch Med Wochenschr 138:319\u2013326 (quiz 327\u2013318)","journal-title":"Dtsch Med Wochenschr"},{"key":"159_CR7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4239\/wjd.v6.i1.67","volume":"6","author":"MP Hansen","year":"2015","unstructured":"Hansen MP, Matheis N, Kahaly GJ (2015) Type 1 diabetes and polyglandular autoimmune syndrome: a review. World J Diabetes 6:67\u201379","journal-title":"World J Diabetes"},{"key":"159_CR8","first-page":"1169","volume-title":"Pathologie der endokrinen Organe II","author":"PU Heitz","year":"1981","unstructured":"Heitz PU, Steiner H (1981) Pluriglandul\u00e4re endokrine Regulationsst\u00f6rungen. C. Autoimmunkrankheiten mit Beteiligung endokriner Dr\u00fcsen: pluriglandul\u00e4re Insuffizienz. In: Doerr W, Seifert G, Uehlinger E (Hrsg) Pathologie der endokrinen Organe II. Springer, Berlin Heidelberg New York, S\u00a01169\u20131203"},{"key":"159_CR9","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1210\/jc.2015-2152","volume":"100","author":"J Honegger","year":"2015","unstructured":"Honegger J, Schlaffer S, Menzel C et\u00a0al (2015) Diagnosis of primary Hypophysitis in Germany. J\u00a0Clin Endocrinol Metab 100:3841\u20133849","journal-title":"J Clin Endocrinol Metab"},{"key":"159_CR10","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1016\/j.lpm.2012.09.011","volume":"41","author":"GJ Kahaly","year":"2012","unstructured":"Kahaly GJ (2012) Polyglandular autoimmune syndrome type II. Presse Med 41:e663\u2013e670","journal-title":"Presse Med"},{"key":"159_CR11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.clim.2015.03.012","volume":"158","author":"N Kluger","year":"2015","unstructured":"Kluger N, Jokinen M, Lintulahti A et al (2015) Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L\u2011amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED. Clin Immunol 158:212\u2013220","journal-title":"Clin Immunol"},{"key":"159_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clim.2011.05.010","volume":"141","author":"I Kobayashi","year":"2011","unstructured":"Kobayashi I, Kubota M, Yamada M et\u00a0al (2011) Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3. Clin Immunol 141:83\u201389","journal-title":"Clin Immunol"},{"issue":"Suppl 2","key":"159_CR13","first-page":"2","volume":"15","author":"HE Lebovitz","year":"2013","unstructured":"Lebovitz HE (2013) Autoimmune polyglandular syndromes: interplay between the immune and the endocrine systems leading to a diverse set of clinical diseases and new insights into immune regulation. Diabetes Technol Ther 15(Suppl 2):2\u201321 (22\u201328)","journal-title":"Diabetes Technol Ther"},{"key":"159_CR14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/bjh.12236","volume":"161","author":"J Li","year":"2013","unstructured":"Li J, Zhou DB (2013) New advances in the diagnosis and treatment of POEMS syndrome. Br J Haematol 161:303\u2013315","journal-title":"Br J Haematol"},{"key":"159_CR15","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/PAS.0000000000000317","volume":"38","author":"R Masia","year":"2014","unstructured":"Masia R, Peyton S, Lauwers GY et\u00a0al (2014) Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases. Am J Surg Pathol 38:1319\u20131329","journal-title":"Am J Surg Pathol"},{"key":"159_CR16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00393-011-0786-6","volume":"70","author":"A Maurer","year":"2011","unstructured":"Maurer A, Schwarting A, Kahaly GJ (2011) Polyglandular autoimmune syndromes. Z Rheumatol 70:752\u2013754 (756\u2013759)","journal-title":"Z Rheumatol"},{"key":"159_CR17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2010.40","volume":"6","author":"AW Michels","year":"2010","unstructured":"Michels AW, Gottlieb PA (2010) Autoimmune polyglandular syndromes. Nat Rev Endocrinol 6:270\u2013277","journal-title":"Nat Rev Endocrinol"},{"key":"159_CR18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MOP.0000000000000107","volume":"26","author":"B Nambam","year":"2014","unstructured":"Nambam B, Winter WE, Schatz DA (2014) IgG4 antibodies in autoimmune polyglandular disease and IgG4-related endocrinopathies: pathophysiology and clinical characteristics. Curr Opin Pediatr 26:493\u2013499","journal-title":"Curr Opin Pediatr"},{"key":"159_CR19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0950-3528(98)90136-1","volume":"12","author":"P Obermayer-Straub","year":"1998","unstructured":"Obermayer-Straub P, Manns MP (1998) Autoimmune polyglandular syndromes. Baillieres Clin Gastroenterol 12:293\u2013315","journal-title":"Baillieres Clin Gastroenterol"},{"key":"159_CR20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/01.mpa.0000220872.18153.72","volume":"32","author":"ES Paiva","year":"2006","unstructured":"Paiva ES, Pereira AE, Lombardi MT et\u00a0al (2006) Insulin autoimmune syndrome (Hirata disease) as differential diagnosis in patients with hyperinsulinemic hypoglycemia. Pancreas 32:431\u2013432","journal-title":"Pancreas"},{"key":"159_CR21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10620-009-0796-2","volume":"55","author":"T Patel","year":"2010","unstructured":"Patel T, Nystrom J, Pyrsopoulos N (2010) Autoimmune hepatitis as a part of polyglandular autoimmune syndrome type II: case report and literature review. Dig Dis Sci 55:861\u2013864","journal-title":"Dig Dis Sci"},{"key":"159_CR22","first-page":"2790","volume":"81","author":"I Pellegrini-Bouiller","year":"1996","unstructured":"Pellegrini-Bouiller I, Belicar P, Barlier A et al (1996) A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency. J Clin Endocrinol Metab 81:2790\u20132796","journal-title":"J Clin Endocrinol Metab"},{"key":"159_CR23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ppul.21520","volume":"47","author":"J Popler","year":"2012","unstructured":"Popler J, Alimohammadi M, Kampe O et\u00a0al (2012) Autoimmune polyendocrine syndrome type 1: Utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab. Pediatr Pulmonol 47:84\u201387","journal-title":"Pediatr Pulmonol"},{"key":"159_CR24","doi-asserted-by":"crossref","first-page":"E292","DOI":"10.1210\/jc.2011-2044","volume":"97","author":"C Posovszky","year":"2012","unstructured":"Posovszky C, Lahr G, Von Schnurbein J et al (2012) Loss of enteroendocrine cells in autoimmune-polyendocrine-candidiasis-ectodermal-dystrophy (APECED) syndrome with gastrointestinal dysfunction. J Clin Endocrinol Metab 97:E292\u2013E300","journal-title":"J Clin Endocrinol Metab"},{"key":"159_CR25","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1016\/j.lpm.2012.10.005","volume":"41","author":"E Proust-Lemoine","year":"2012","unstructured":"Proust-Lemoine E, Saugier-Veber P, Wemeau JL (2012) Polyglandular autoimmune syndrome type I. Presse Med 41:e651\u2013e662","journal-title":"Presse Med"},{"key":"159_CR26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/MOP.0b013e328354ccdf","volume":"24","author":"L Rigoli","year":"2012","unstructured":"Rigoli L, Di Bella C (2012) Wolfram syndrome 1 and Wolfram syndrome 2. Curr Opin Pediatr 24:512\u2013517","journal-title":"Curr Opin Pediatr"},{"key":"159_CR27","first-page":"939","volume":"10","author":"Y Sherer","year":"1997","unstructured":"Sherer Y, Bardayan Y, Shoenfeld Y (1997) Thymoma, thymic hyperplasia, thymectomy and autoimmune diseases (Review). Int J Oncol 10:939\u2013943","journal-title":"Int J Oncol"},{"key":"159_CR28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.clim.2014.12.007","volume":"156","author":"MM Xavier-Da-Silva","year":"2015","unstructured":"Xavier-Da-Silva MM, Moreira-Filho CA, Suzuki E et al (2015) Fetal-onset IPEX: report of two families and review of literature. Clin Immunol 156:131\u2013140","journal-title":"Clin Immunol"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-016-0159-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-016-0159-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-016-0159-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T04:58:18Z","timestamp":1655528298000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-016-0159-7"}},"subtitle":["Ein \u00dcberblick","An overview"],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["159"],"URL":"https:\/\/doi.org\/10.1007\/s00292-016-0159-7","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,20]]}}}