{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:37:37Z","timestamp":1792247857244,"version":"4.4.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:00:00Z","timestamp":1470268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00292-016-0196-2","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T11:33:35Z","timestamp":1470310415000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mediastinale Keimzelltumoren","Mediastinal germ cell tumors"],"prefix":"10.1007","volume":"37","author":[{"given":"F.","family":"Bremmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Str\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,4]]},"reference":[{"issue":"4","key":"196_CR1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1200\/JCO.2000.18.4.832","volume":"18","author":"DT Schneider","year":"2000","unstructured":"Schneider DT et\u00a0al (2000) Primary mediastinal germ cell tumors in children and adolescents: Results of the German cooperative protocols MAKEI 83\/86, 89, and 96. J\u00a0Clin Oncol 18(4):832\u2013839","journal-title":"J Clin Oncol"},{"issue":"1","key":"196_CR2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/PAS.0b013e3181379edf","volume":"32","author":"MT Sung","year":"2008","unstructured":"Sung MT et\u00a0al (2008) Primary mediastinal seminoma: A\u00a0comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases. Am J Surg Pathol 32(1):146\u2013155","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"196_CR3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jso.10231","volume":"83","author":"S Takeda","year":"2003","unstructured":"Takeda S et\u00a0al (2003) Clinical spectrum of primary mediastinal tumors: A\u00a0omparison of adult and pediatric populations at a single Japanese institution. J\u00a0Surg Oncol 83(1):24\u201330","journal-title":"J Surg Oncol"},{"issue":"7","key":"196_CR4","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/1097-0142(20010401)91:7<1394::AID-CNCR1144>3.0.CO;2-Y","volume":"91","author":"C Bokemeyer","year":"2001","unstructured":"Bokemeyer C et\u00a0al (2001) Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. Cancer 91(7):1394\u20131401","journal-title":"Cancer"},{"issue":"2","key":"196_CR5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.athoracsur.2007.09.020","volume":"85","author":"KA Kesler","year":"2008","unstructured":"Kesler KA et al (2008) A 25-year single institution experience with surgery for primary mediastinal nonseminomatous germ cell tumors. Ann Thorac Surg 85(2):371\u2013378","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"196_CR6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/PAP.0b013e318248b725","volume":"19","author":"A Weissferdt","year":"2012","unstructured":"Weissferdt A, Suster S, Moran CA (2012) Primary mediastinal \u201cthymic\u201d seminomas. Adv Anat Pathol 19(2):75\u201380","journal-title":"Adv Anat Pathol"},{"issue":"4","key":"196_CR7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/(SICI)1097-0142(19970815)80:4<691::AID-CNCR7>3.0.CO;2-Q","volume":"80","author":"CA Moran","year":"1997","unstructured":"Moran CA et\u00a0al (1997) Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas \u2013 a\u00a0clinicopathologic and immunohistochemical study of 120 cases. Cancer 80(4):691\u2013698","journal-title":"Cancer"},{"issue":"2","key":"196_CR8","first-page":"463","volume":"146","author":"U Latza","year":"1995","unstructured":"Latza U et\u00a0al (1995) CD30 antigen in embryonal carcinoma and embryogenesis and release of the soluble molecule. Am J Pathol 146(2):463\u2013471","journal-title":"Am J Pathol"},{"issue":"4","key":"196_CR9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mtc.2003.407","volume":"125","author":"KA Kesler","year":"2003","unstructured":"Kesler KA et al (2003) Mediastinal metastases from testicular nonseminomatous germ cell tumors: Patterns of dissemination and predictors of long-term survival with surgery. J Thorac Cardiovasc Surg 125(4):913\u2013923","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"196_CR10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.canep.2013.04.003","volume":"37","author":"C Rusner","year":"2013","unstructured":"Rusner C et\u00a0al (2013) Incidence patterns and trends of malignant gonadal and extragonadal germ cell tumors in Germany, 1998\u20132008. Cancer Epidemiol 37(4):370\u2013373","journal-title":"Cancer Epidemiol"},{"issue":"1","key":"196_CR11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gcc.10053","volume":"34","author":"DT Schneider","year":"2002","unstructured":"Schneider DT et\u00a0al (2002) Genetic analysis of mediastinal nonseminomatous germ cell tumors in children and adolescents. Genes Chromosomes Cancer 34(1):115\u2013125","journal-title":"Genes Chromosomes Cancer"},{"issue":"20","key":"196_CR12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJM199005173222004","volume":"322","author":"CR Nichols","year":"1990","unstructured":"Nichols CR et al (1990) Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med 322(20):1425\u20131429","journal-title":"N Engl J Med"},{"issue":"6","key":"196_CR13","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.urolonc.2010.08.005","volume":"30","author":"AJ Rodney","year":"2012","unstructured":"Rodney AJ et al (2012) Survival outcomes for men with mediastinal germ-cell tumors: The University of Texas M. D. Anderson Cancer Center experience. Urol Oncol 30(6):879\u2013885","journal-title":"Urol Oncol"},{"issue":"6","key":"196_CR14","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/1097-0142(19930915)72:6<1894::AID-CNCR2820720617>3.0.CO;2-6","volume":"72","author":"EM Dulmet","year":"1993","unstructured":"Dulmet EM et al (1993) Germ cell tumors of the mediastinum. A\u00a030-year experience. Cancer 72(6):1894\u20131901","journal-title":"Cancer"},{"issue":"4","key":"196_CR15","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/1097-0142(197404)33:4<1196::AID-CNCR2820330445>3.0.CO;2-0","volume":"33","author":"EA Sickles","year":"1974","unstructured":"Sickles EA, Belliveau RE, Wiernik PH (1974) Primary mediastinal choriocarcinoma in the male. Cancer 33(4):1196\u20131203","journal-title":"Cancer"},{"issue":"2","key":"196_CR16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1272\/jnms.75.116","volume":"75","author":"K Yokoi","year":"2008","unstructured":"Yokoi K et\u00a0al (2008) Male choriocarcinoma with metastasis to the jejunum: A case report and review of the literature. J\u00a0Nippon Med Sch 75(2):116\u2013121","journal-title":"J Nippon Med Sch"},{"issue":"6","key":"196_CR17","first-page":"781","volume":"42","author":"T Ertugrul","year":"2001","unstructured":"Ertugrul T et\u00a0al (2001) An intrapericardial teratoma with endocrine function. J\u00a0Cardiovasc Surg (Torino) 42(6):781\u2013783","journal-title":"J Cardiovasc Surg (Torino)"},{"issue":"5","key":"196_CR18","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1378\/chest.102.5.1477","volume":"102","author":"E Lemarie","year":"1992","unstructured":"Lemarie E et\u00a0al (1992) Primary mediastinal germ cell tumors. Results of a\u00a0French retrospective study. Chest 102(5):1477\u20131483","journal-title":"Chest"},{"issue":"1","key":"196_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gcc.2870120103","volume":"12","author":"J Echten van","year":"1995","unstructured":"van Echten J et\u00a0al (1995) Definition of a\u00a0new entity of malignant extragonadal germ cell tumors. Genes Chromosomes Cancer 12(1):8\u201315","journal-title":"Genes Chromosomes Cancer"},{"issue":"10","key":"196_CR20","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/jcp.37.10.1105","volume":"37","author":"PJ Dunn","year":"1984","unstructured":"Dunn PJ (1984) Pancreatic endocrine tissue in benign mediastinal teratoma. J\u00a0Clin Pathol 37(10):1105\u20131109","journal-title":"J Clin Pathol"},{"issue":"5\u202fC","key":"196_CR21","first-page":"3723","volume":"20","author":"A Iyoda","year":"2000","unstructured":"Iyoda A et\u00a0al (2000) The primary mediastinal growing teratoma syndrome. Anticancer Res 20(5\u202fC):3723\u20133726","journal-title":"Anticancer Res"},{"issue":"7","key":"196_CR22","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1200\/JCO.2002.07.062","volume":"20","author":"C Bokemeyer","year":"2002","unstructured":"Bokemeyer C et\u00a0al (2002) Extragonadal germ cell tumors of the mediastinum and retroperitoneum: Results from an international analysis. J\u00a0Clin Oncol 20(7):1864\u20131873","journal-title":"J Clin Oncol"},{"issue":"9","key":"196_CR23","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/1097-0142(19841101)54:9<1824::AID-CNCR2820540910>3.0.CO;2-J","volume":"54","author":"TM Ulbright","year":"1984","unstructured":"Ulbright TM et al (1984) The development of non-germ cell malignancies within germ cell tumors. A\u00a0clinicopathologic study of 11 cases. Cancer 54(9):1824\u20131833","journal-title":"Cancer"},{"issue":"1","key":"196_CR24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-5347(01)64035-7","volume":"159","author":"RJ Motzer","year":"1998","unstructured":"Motzer RJ et\u00a0al (1998) Teratoma with malignant transformation: Diverse malignant histologies arising in men with germ cell tumors. J\u00a0Urol 159(1):133\u2013138","journal-title":"J Urol"},{"issue":"1","key":"196_CR25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/jnci\/92.1.54","volume":"92","author":"JT Hartmann","year":"2000","unstructured":"Hartmann JT et\u00a0al (2000) Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors. J\u00a0Natl Cancer Inst 92(1):54\u201361","journal-title":"J Natl Cancer Inst"},{"issue":"1B","key":"196_CR26","first-page":"527","volume":"20","author":"M Ohtsuka","year":"2000","unstructured":"Ohtsuka M et\u00a0al (2000) Disseminated metastasis of neuroblastomatous component in immature mediastinal teratoma: A\u00a0case report. Anticancer Res 20(1B):527\u2013530","journal-title":"Anticancer Res"},{"issue":"5","key":"196_CR27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00428-013-1476-3","volume":"463","author":"IM Schaefer","year":"2013","unstructured":"Schaefer IM et al (2013) Neuroendocrine carcinoma in a mediastinal teratoma as a\u00a0rare variant of somatic-type malignancy. Virchows Arch 463(5):731\u2013735","journal-title":"Virchows Arch"},{"issue":"3","key":"196_CR28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jnci\/82.3.221","volume":"82","author":"M Ladanyi","year":"1990","unstructured":"Ladanyi M et\u00a0al (1990) Cytogenetic and immunohistochemical evidence for the germ cell origin of a\u00a0subset of acute leukemias associated with mediastinal germ cell tumors. J\u00a0Natl Cancer Inst 82(3):221\u2013227","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"196_CR29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-4608(94)90224-0","volume":"77","author":"F Sole","year":"1994","unstructured":"Sole F et al (1994) Refractory anemia with excess of blasts and isochromosome 12p in a\u00a0patient with primary mediastinal germ-cell tumor. Cancer Genet Cytogenet 77(2):111\u2013113","journal-title":"Cancer Genet Cytogenet"},{"issue":"5","key":"196_CR30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0046-8177(88)80209-0","volume":"19","author":"M Ladanyi","year":"1988","unstructured":"Ladanyi M, Roy I (1988) Mediastinal germ cell tumors and histiocytosis. Hum Pathol 19(5):586\u2013590","journal-title":"Hum Pathol"},{"issue":"10","key":"196_CR31","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1200\/JCO.1998.16.10.3386","volume":"16","author":"C Kollmannsberger","year":"1998","unstructured":"Kollmannsberger C et\u00a0al (1998) Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumors. J\u00a0Clin Oncol 16(10):3386\u20133391","journal-title":"J Clin Oncol"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-016-0196-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-016-0196-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-016-0196-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:57:50Z","timestamp":1498319870000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-016-0196-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,4]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["196"],"URL":"https:\/\/doi.org\/10.1007\/s00292-016-0196-2","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,4]]}}}