{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:20Z","timestamp":1787161580845,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00292-017-0370-1","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T07:41:04Z","timestamp":1507102864000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Morphologische Ver\u00e4nderungen des Knochengewebes bei\u00a0Osteopetrose","Morphological characteristics of osteopetrosis"],"prefix":"10.1007","volume":"39","author":[{"given":"J.","family":"Zustin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Crazzolara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Butscheidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Oheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"370_CR1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"DM Anderson","year":"1997","unstructured":"Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L (1997) A homologue of the TNF receptor and its ligand enhance T\u2011cell growth and dendritic-cell function. Nature 390:175\u2013179","journal-title":"Nature"},{"key":"370_CR2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jbmr.2100","volume":"29","author":"F Barvencik","year":"2014","unstructured":"Barvencik F, Kurth I, Koehne T, Stauber T, Zustin J, Tsiakas K, Ludwig CF, Beil FT, Pestka JM, Hahn M, Santer R, Supanchart C, Kornak U, Del Fattore A, Jentsch TJ, Teti A, Schulz A, Schinke T, Amling M (2014) Clcn7 and Tcirg1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals. J\u00a0Bone Miner Res 29:982\u2013991","journal-title":"J Bone Miner Res"},{"key":"370_CR3","doi-asserted-by":"publisher","first-page":"372156","DOI":"10.1155\/2015\/372156","volume":"2015","author":"AE Coudert","year":"2015","unstructured":"Coudert AE, de Vernejoul MC, Muraca M, Del Fattore A (2015) Osteopetrosis and its relevance for the discovery of new functions associated with the skeleton. Int J Endocrinol 2015:372156. https:\/\/doi.org\/10.1155\/2015\/372156","journal-title":"Int J Endocrinol"},{"key":"370_CR4","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","volume":"13","author":"WC Dougall","year":"1999","unstructured":"Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J (1999) Rank is essential for osteoclast and lymph node development. Genes Dev 13:2412\u20132424","journal-title":"Genes Dev"},{"key":"370_CR5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(00)00103-3","volume":"103","author":"JE Fata","year":"2000","unstructured":"Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM (2000) The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103:41\u201350","journal-title":"Cell"},{"key":"370_CR6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1084\/jem.188.5.997","volume":"188","author":"K Fuller","year":"1998","unstructured":"Fuller K, Wong B, Fox S, Choi Y, Chambers TJ (1998) Trance is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J\u00a0Exp Med 188:997\u20131001","journal-title":"J Exp Med"},{"key":"370_CR7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00109-011-0749-z","volume":"89","author":"R Hanada","year":"2011","unstructured":"Hanada R, Hanada T, Sigl V, Schramek D, Penninger JM (2011) Rankl\/Rank-beyond bones. J\u00a0Mol Med 89:647\u2013656","journal-title":"J Mol Med"},{"key":"370_CR8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature08596","volume":"462","author":"R Hanada","year":"2009","unstructured":"Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, von Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl S, Narumiya S, Penninger JM (2009) Central control of fever and female body temperature by Rankl\/Rank. Nature 462:505\u2013509","journal-title":"Nature"},{"key":"370_CR9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nature04524","volume":"440","author":"DH Jones","year":"2006","unstructured":"Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, Khokha R, Wada T, Penninger JM (2006) Regulation of cancer cell migration and bone metastasis by RANKL. Nature 440:692\u2013696","journal-title":"Nature"},{"key":"370_CR10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10875-008-9226-z","volume":"29","author":"SS Kilic","year":"2009","unstructured":"Kilic SS, Etzioni A (2009) The clinical spectrum of leukocyte adhesion deficiency (LAD) III due to defective Caldag-Gef1. J\u00a0Clin Immunol 29:117\u2013122","journal-title":"J Clin Immunol"},{"key":"370_CR11","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1073\/pnas.200294797","volume":"97","author":"N Kim","year":"2000","unstructured":"Kim N, Odgren PR, Kim DK, Marks SC Jr., Choi Y (2000) Diverse roles of the tumor necrosis factor family member trance in skeletal physiology revealed by trance deficiency and partial rescue by a\u00a0lymphocyte-expressed trance transgene. Proc Natl Acad Sci USA 97:10905\u201310910","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"370_CR12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999) Opgl is a\u00a0key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315\u2013323","journal-title":"Nature"},{"key":"370_CR13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","volume":"104","author":"U Kornak","year":"2001","unstructured":"Kornak U, Kasper D, Bosl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ (2001) Loss of the CLC-7 chloride channel leads to osteopetrosis in mice and man. Cell 104:205\u2013215","journal-title":"Cell"},{"key":"370_CR14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00198-014-2965-1","volume":"26","author":"M Krause","year":"2015","unstructured":"Krause M, Keller J, Beil B, van Driel I, Zustin J, Barvencik F, Schinke T, Amling M (2015) Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int 26:987\u2013995","journal-title":"Osteoporos Int"},{"key":"370_CR15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0002-9440(10)64556-7","volume":"157","author":"DL Lacey","year":"2000","unstructured":"Lacey DL, Tan HL, Lu J, Kaufman S, Van G, Qiu W, Rattan A, Scully S, Fletcher F, Juan T, Kelley M, Burgess TL, Boyle WJ, Polverino AJ (2000) Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 157:435\u2013448","journal-title":"Am J Pathol"},{"key":"370_CR16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a\u00a0cytokine that regulates osteoclast differentiation and activation. Cell 93:165\u2013176","journal-title":"Cell"},{"key":"370_CR17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature04535","volume":"440","author":"PF Lange","year":"2006","unstructured":"Lange PF, Wartosch L, Jentsch TJ, Fuhrmann JC (2006) Clc-7 Requires Ostm1 as a\u00a0beta-subunit to support bone resorption and lysosomal function. Nature 440:220\u2013223","journal-title":"Nature"},{"key":"370_CR18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/978-0-387-89520-8_9","volume":"647","author":"A Leibbrandt","year":"2009","unstructured":"Leibbrandt A, Penninger JM (2009) RANK(L) as a\u00a0key target for controlling bone loss. Adv Exp Med Biol 647:130\u2013145","journal-title":"Adv. Exp. Med. Biol."},{"key":"370_CR19","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","volume":"97","author":"J Li","year":"2000","unstructured":"Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ (2000) Rank is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 97:1566\u20131571","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"370_CR20","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1182\/blood-2009-08-238709","volume":"115","author":"A McDowall","year":"2010","unstructured":"McDowall A, Svensson S, Stanley P, Patzak I, Chakravarty P, Howarth K, Sabnis H, Briones H, Hogg N (2010) Two mutations in the Kindlin3 gene of a\u00a0new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro. Blood 115:4834\u20134842","journal-title":"Blood"},{"key":"370_CR21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nm.1921","volume":"15","author":"M Moser","year":"2009","unstructured":"Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt S, Wang HV, Sperandio M, Fassler R (2009) Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med 15:300\u2013305","journal-title":"Nat Med"},{"key":"370_CR22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nm1722","volume":"14","author":"M Moser","year":"2008","unstructured":"Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R (2008) Kindlin-3 Is essential for integrin activation and platelet aggregation. Nat Med 14:325\u2013330","journal-title":"Nat Med"},{"key":"370_CR23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1084\/jem.20062497","volume":"204","author":"SW Rossi","year":"2007","unstructured":"Rossi SW, Kim MY, Leibbrandt A, Parnell SM, Jenkinson WE, Glanville SH, McConnell FM, Scott HS, Penninger JM, Jenkinson EJ, Lane PJ, Anderson G (2007) Rank signals from Cd4(+)3(\u2212) inducer cells regulate development of aire-expressing epithelial cells in the thymic medulla. J\u00a0Exp Med 204:1267\u20131272","journal-title":"J Exp Med"},{"key":"370_CR24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/pbc.22386","volume":"55","author":"H Sabnis","year":"2010","unstructured":"Sabnis H, Kirpalani H, Horan J, McDowall A, Svensson L, Cooley A, Merck T, Jobe S, Hogg N, Briones M (2010) Leukocyte adhesion deficiency-III in an african-american patient. Pediatr Blood Cancer 55:180\u2013182","journal-title":"Pediatr Blood Cancer"},{"key":"370_CR25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nm.1963","volume":"15","author":"T Schinke","year":"2009","unstructured":"Schinke T, Schilling AF, Baranowsky A, Seitz S, Marshall RP, Linn T, Blaeker M, Huebner AK, Schulz A, Simon R, Gebauer M, Priemel M, Kornak U, Perkovic S, Barvencik F, Beil FT, Del Fattore A, Frattini A, Streichert T, Pueschel K, Villa A, Debatin KM, Rueger JM, Teti A, Zustin J, Sauter G, Amling M (2009) Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med 15:674\u2013681","journal-title":"Nat Med"},{"key":"370_CR26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm.1931","volume":"15","author":"L Svensson","year":"2009","unstructured":"Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N (2009) Leukocyte adhesion deficiency-III is caused by mutations in Kindlin3 affecting integrin activation. Nat Med 15:306\u2013312","journal-title":"Nat Med"},{"key":"370_CR27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","volume":"7","author":"H Takayanagi","year":"2007","unstructured":"Takayanagi H (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7:292\u2013304","journal-title":"Nat Rev Immunol"},{"key":"370_CR28","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1126\/science.1188072","volume":"328","author":"S Weinert","year":"2010","unstructured":"Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U, Jentsch TJ (2010) Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl-accumulation. Science 328:1401\u20131403","journal-title":"Science"},{"key":"370_CR29","doi-asserted-by":"crossref","first-page":"25190","DOI":"10.1074\/jbc.272.40.25190","volume":"272","author":"BR Wong","year":"1997","unstructured":"Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS 3rd, Frankel WN, Lee SY, Choi Y (1997) Trance is a\u00a0novel ligand of the tumor necrosis factor receptor family that activates C\u2011jun N\u2011terminal kinase in T cells. J\u00a0Biol Chem 272:25190\u201325194","journal-title":"J Biol Chem"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-017-0370-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-017-0370-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-017-0370-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T14:23:09Z","timestamp":1603030989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-017-0370-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["370"],"URL":"https:\/\/doi.org\/10.1007\/s00292-017-0370-1","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,4]]}}}