{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T06:19:41Z","timestamp":1648793981414},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"S3","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00292-019-00694-7","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T15:06:44Z","timestamp":1573225604000},"page":"265-270","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphomolekulare Charakterisierung kolorektaler Neoplasien"],"prefix":"10.1007","volume":"40","author":[{"given":"M.","family":"Jesinghaus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"694_CR1","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1200\/JCO.2007.14.7116","volume":"26","author":"RG Amado","year":"2008","unstructured":"Amado\u00a0RG, Wolf\u00a0M, Peeters\u00a0M et al (2008) Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J\u00a0Clin Oncol 26:1626\u20131634","journal-title":"J Clin Oncol"},{"key":"694_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1056\/NEJMoa1305275","volume":"369","author":"JY Douillard","year":"2013","unstructured":"Douillard\u00a0JY, Oliner\u00a0KS, Siena\u00a0S et al (2013) Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 369:1023\u20131034","journal-title":"N. Engl. J. Med."},{"key":"694_CR3","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev-pathol-011110-130235","volume":"6","author":"ER Fearon","year":"2011","unstructured":"Fearon\u00a0ER (2011) Molecular genetics of colorectal cancer. Annu Rev Pathol 6:479\u2013507","journal-title":"Annu Rev Pathol"},{"key":"694_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1053\/j.gastro.2014.11.024","volume":"148","author":"ER Fearon","year":"2015","unstructured":"Fearon\u00a0ER, Carethers\u00a0JM (2015) Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome. Gastroenterology 148:10\u201313","journal-title":"Gastroenterology"},{"key":"694_CR5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","volume":"61","author":"ER Fearon","year":"1990","unstructured":"Fearon\u00a0ER, Vogelstein\u00a0B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759\u2013767","journal-title":"Cell"},{"key":"694_CR6","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1097\/PAS.0000000000000423","volume":"39","author":"M Jesinghaus","year":"2015","unstructured":"Jesinghaus\u00a0M, Wolf\u00a0T, Pfarr\u00a0N et al (2015) Distinctive spatiotemporal stability of somatic mutations in metastasized microsatellite-stable colorectal cancer. Am J Surg Pathol 39:1140\u20131147","journal-title":"Am J Surg Pathol"},{"key":"694_CR7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/gcc.22352","volume":"55","author":"M Jesinghaus","year":"2016","unstructured":"Jesinghaus\u00a0M, Pfarr\u00a0N, Endris\u00a0V et\u00a0al (2016a) Genotyping of colorectal cancer for cancer precision medicine: results from the IPH Center for Molecular Pathology. Genes Chromosomes Cancer 55:505\u2013521","journal-title":"Genes Chromosomes Cancer"},{"key":"694_CR8","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/gcc.22330","volume":"55","author":"M Jesinghaus","year":"2016","unstructured":"Jesinghaus\u00a0M, Pfarr\u00a0N, Kloor\u00a0M et\u00a0al (2016b) Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies. Genes Chromosomes Cancer 55:268\u2013277","journal-title":"Genes Chromosomes Cancer"},{"key":"694_CR9","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/modpathol.2016.220","volume":"30","author":"M Jesinghaus","year":"2017","unstructured":"Jesinghaus\u00a0M, Konukiewitz\u00a0B, Keller\u00a0G et\u00a0al (2017) Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas. Mod Pathol 30:610\u2013619","journal-title":"Mod Pathol"},{"key":"694_CR10","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/modpathol.2017.184","volume":"31","author":"M Jesinghaus","year":"2018","unstructured":"Jesinghaus\u00a0M, Konukiewitz\u00a0B, Foersch\u00a0S et al (2018) Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. Mod Pathol 31:829\u2013839","journal-title":"Mod Pathol"},{"key":"694_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature11252","volume":"487","author":"The Cancer Genome Atlas Network","year":"2012","unstructured":"The Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330\u2013337","journal-title":"Nature"},{"key":"694_CR12","volume-title":"WHO classification of tumours of the digestive system","author":"WHO Editorial Board","year":"2019","unstructured":"WHO Editorial Board (2019) WHO classification of tumours of the digestive system, 5.\u00a0Aufl.","edition":"5"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-019-00694-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-019-00694-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-019-00694-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T01:04:23Z","timestamp":1604711063000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-019-00694-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":12,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["694"],"URL":"https:\/\/doi.org\/10.1007\/s00292-019-00694-7","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"assertion":[{"value":"8 November 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"M.\u00a0Jesinghaus gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"The supplement containing this article is not sponsored by industry.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}