{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:59:09Z","timestamp":1787921949697,"version":"build-2784847793"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologe"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00292-020-00756-1","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T15:02:41Z","timestamp":1582210961000},"page":"163-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Die Rolle von Interleukin-11 beim\u00a0Osteosarkom","The role of interleukin-11 in osteosarcoma"],"prefix":"10.1007","volume":"41","author":[{"given":"Juliane","family":"Lokau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Schoeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Garbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"756_CR1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.celrep.2018.09.005","volume":"25","author":"M Agthe","year":"2018","unstructured":"Agthe\u00a0M, Brugge\u00a0J, Garbers\u00a0Y et al (2018) Mutations in craniosynostosis patients cause defective Interleukin-11 receptor maturation and drive craniosynostosis-like disease in mice. Cell Rep 25:10\u201318e5","journal-title":"Cell Rep"},{"key":"756_CR2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-04566-0","volume-title":"Urogenitale und Endokrine Organe, Gelenke und Skelett","author":"K Amann","year":"2016","unstructured":"Amann\u00a0K, Kain\u00a0R, Kl\u00f6ppel\u00a0G (2016) Urogenitale und Endokrine Organe, Gelenke und Skelett. Springer, Berlin Heidelberg"},{"key":"756_CR3","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.ejca.2011.05.030","volume":"47","author":"JK Anninga","year":"2011","unstructured":"Anninga\u00a0JK, Gelderblom\u00a0H, Fiocco\u00a0M et\u00a0al (2011) Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand? Eur J Cancer 47:2431\u20132445","journal-title":"Eur J Cancer"},{"key":"756_CR4","doi-asserted-by":"crossref","first-page":"36197","DOI":"10.1074\/jbc.M004648200","volume":"275","author":"VA Barton","year":"2000","unstructured":"Barton\u00a0VA, Hall\u00a0MA, Hudson\u00a0KR et al (2000) Interleukin-11 signals through the formation of a\u00a0hexameric receptor complex. J\u00a0Biol Chem 275:36197\u201336203","journal-title":"J Biol Chem"},{"key":"756_CR5","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/ncomms2393","volume":"4","author":"J Bockhorn","year":"2013","unstructured":"Bockhorn\u00a0J, Dalton\u00a0R, Nwachukwu\u00a0C et al (2013) MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun 4:1393","journal-title":"Nat Commun"},{"key":"756_CR6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/cge.13409","volume":"94","author":"E Brischoux-Boucher","year":"2018","unstructured":"Brischoux-Boucher\u00a0E, Trimouille\u00a0A, Baujat\u00a0G et al (2018) IL11RA-related Crouzon-like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clin Genet 94:373\u2013380","journal-title":"Clin Genet"},{"key":"756_CR7","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/gut.45.6.895","volume":"45","author":"CC Chen","year":"1999","unstructured":"Chen\u00a0CC, Wang\u00a0SS, Lu\u00a0RH et\u00a0al (1999) Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis. Gut 45:895\u2013899","journal-title":"Gut"},{"key":"756_CR8","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1182\/blood.V86.7.2534.bloodjournal8672534","volume":"86","author":"M Ch\u00e9rel","year":"1995","unstructured":"Ch\u00e9rel\u00a0M, Sorel\u00a0M, Lebeau\u00a0B et al (1995) Molecular cloning of two isoforms of a\u00a0receptor for the human hematopoietic cytokine interleukin-11. Blood 86:2534\u20132540","journal-title":"Blood"},{"key":"756_CR9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ajmg.a.38540","volume":"176","author":"CM Clarke","year":"2018","unstructured":"Clarke\u00a0CM, Fok\u00a0VT, Gustafson\u00a0JA et\u00a0al (2018) Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms. Am J Med Genet\u00a0A 176:290\u2013300","journal-title":"Am J Med Genet A"},{"key":"756_CR10","volume-title":"Bone tumors : general aspects and data on 8,542 cases","author":"DC Dahlin","year":"1986","unstructured":"Dahlin\u00a0DC, Unni\u00a0KK (1986) Bone tumors : general aspects and data on 8,542 cases. Thomas, Springfield"},{"key":"756_CR11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/bjc.1986.110","volume":"53","author":"GJ Draper","year":"1986","unstructured":"Draper\u00a0GJ, Sanders\u00a0BM, Kingston\u00a0JE (1986) Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53:661\u2013671","journal-title":"Br J Cancer"},{"key":"756_CR12","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1182\/blood.V89.11.3897","volume":"89","author":"X Du","year":"1997","unstructured":"Du\u00a0X, Williams\u00a0D (1997) Interleukin-11: review of molecular, cell biology, and clinical use. Blood 89:3897\u20133908","journal-title":"Blood"},{"key":"756_CR13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/endo.136.2.7835281","volume":"136","author":"JA Elias","year":"1995","unstructured":"Elias\u00a0JA, Tang\u00a0W, Horowitz\u00a0MC (1995) Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. Endocrinology 136:489\u2013498","journal-title":"Endocrinology"},{"key":"756_CR14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1748-717X-7-140","volume":"7","author":"MK Farris","year":"2012","unstructured":"Farris\u00a0MK, Chowdhry\u00a0VK, Lemke\u00a0S et\u00a0al (2012) Osteosarcoma following single fraction radiation prophylaxis for heterotopic ossification. Radiat Oncol 7:140","journal-title":"Radiat Oncol"},{"key":"756_CR15","volume-title":"WHO classification of tumours of soft tissue and bone","author":"CDM Fletcher","year":"2013","unstructured":"Fletcher\u00a0CDM, Bridge\u00a0JA, Hogendoorn\u00a0PCW et\u00a0al (2013) WHO classification of tumours of soft tissue and bone. International Agency for Research on Cancer, Lyon"},{"key":"756_CR16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrd.2018.45","volume":"17","author":"C Garbers","year":"2018","unstructured":"Garbers\u00a0C, Heink\u00a0S, Korn\u00a0T et al (2018) Interleukin-6: designing specific therapeutics for a\u00a0complex cytokine. Nat Rev Drug Discov 17:395\u2013412","journal-title":"Nat Rev Drug Discov"},{"key":"756_CR17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","volume":"23","author":"C Garbers","year":"2012","unstructured":"Garbers\u00a0C, Hermanns\u00a0H, Schaper\u00a0F et al (2012) Plasticity and cross-talk of Interleukin 6\u2011type cytokines. Cytokine Growth Factor Rev 23:85\u201397","journal-title":"Cytokine Growth Factor Rev"},{"key":"756_CR18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1515\/hsz-2013-0166","volume":"394","author":"C Garbers","year":"2013","unstructured":"Garbers\u00a0C, Scheller\u00a0J (2013) Interleukin\u20116 and interleukin-11: same same but different. Biol Chem 394:1145\u20131161","journal-title":"Biol Chem"},{"key":"756_CR19","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S0959-8049(02)00037-0","volume":"38","author":"EI Hauben","year":"2002","unstructured":"Hauben\u00a0EI, Weeden\u00a0S, Pringle\u00a0J et al (2002) Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? A study on 570 patients of two consecutive trials of the European Osteosarcoma Intergroup. Eur J Cancer 38:1218\u20131225","journal-title":"Eur J Cancer"},{"key":"756_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","volume":"374","author":"PC Heinrich","year":"2003","unstructured":"Heinrich\u00a0PC, Behrmann\u00a0I, Haan\u00a0S et al (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem\u00a0J 374:1\u201320","journal-title":"Biochem J"},{"key":"756_CR21","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1182\/blood.V94.11.3883","volume":"94","author":"O Hjertner","year":"1999","unstructured":"Hjertner\u00a0O, Torgersen\u00a0ML, Seidel\u00a0C et al (1999) Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a\u00a0possible role for HGF in myeloma-associated osteolytic bone disease. Blood 94:3883\u20133888","journal-title":"Blood"},{"key":"756_CR22","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1210\/endo.139.11.6433","volume":"139","author":"NJ Horwood","year":"1998","unstructured":"Horwood\u00a0NJ, Elliott\u00a0J, Martin\u00a0TJ et\u00a0al (1998) Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 139:4743\u20134746","journal-title":"Endocrinology"},{"key":"756_CR23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/j.gastro.2008.12.003","volume":"136","author":"M Howlett","year":"2009","unstructured":"Howlett\u00a0M, Giraud\u00a0A, Lescesen\u00a0H et al (2009) The interleukin\u20116 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology 136:967\u2013977","journal-title":"Gastroenterology"},{"key":"756_CR24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1158\/0008-5472.CAN-11-2778","volume":"72","author":"G Huang","year":"2012","unstructured":"Huang\u00a0G, Yu\u00a0L, Cooper\u00a0LJ et al (2012) Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases. Cancer Res 72:271\u2013281","journal-title":"Cancer Res"},{"key":"756_CR25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cytogfr.2015.07.015","volume":"26","author":"CN Johnstone","year":"2015","unstructured":"Johnstone\u00a0CN, Chand\u00a0A, Putoczki\u00a0TL et al (2015) Emerging roles for IL-11 signaling in cancer development and progression: focus on breast cancer. Cytokine Growth Factor Rev 26:489\u2013498","journal-title":"Cytokine Growth Factor Rev"},{"key":"756_CR26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-5793(91)80587-S","volume":"283","author":"I Kawashima","year":"1991","unstructured":"Kawashima\u00a0I, Ohsumi\u00a0J, Mita-Honjo\u00a0K et al (1991) Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. Febs Lett 283:199\u2013202","journal-title":"Febs Lett"},{"key":"756_CR27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/mgg3.28","volume":"1","author":"K Keupp","year":"2013","unstructured":"Keupp\u00a0K, Li\u00a0Y, Vargel\u00a0I et al (2013) Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis. Mol Genet Genomic Med 1:223\u2013237","journal-title":"Mol Genet Genomic Med"},{"key":"756_CR28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/ajmg.a.61070","volume":"179","author":"N Korakavi","year":"2019","unstructured":"Korakavi\u00a0N, Prokop\u00a0JW, Seaver\u00a0LH (2019) Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a\u00a0Crouzon-like autosomal recessive syndrome. Am J Med Genet\u00a0A 179:668\u2013673","journal-title":"Am J Med Genet A"},{"key":"756_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","volume":"32","author":"O Kudo","year":"2003","unstructured":"Kudo\u00a0O, Sabokbar\u00a0A, Pocock\u00a0A et al (2003) Interleukin\u20116 and interleukin-11 support human osteoclast formation by a\u00a0RANKL-independent mechanism. Bone 32:1\u20137","journal-title":"Bone"},{"key":"756_CR30","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1158\/0008-5472.CAN-08-4845","volume":"69","author":"V Lewis","year":"2009","unstructured":"Lewis\u00a0V, Ozawa\u00a0M, Deavers\u00a0M et al (2009) The interleukin-11 receptor alpha as a\u00a0candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. Cancer Res 69:1995\u20131999","journal-title":"Cancer Res"},{"key":"756_CR31","doi-asserted-by":"crossref","first-page":"8065","DOI":"10.1073\/pnas.1704173114","volume":"114","author":"VO Lewis","year":"2017","unstructured":"Lewis\u00a0VO, Devarajan\u00a0E, Cardo-Vila\u00a0M et al (2017) BMTP-11 is active in preclinical models of human osteosarcoma and a\u00a0candidate targeted drug for clinical translation. Proc Natl Acad Sci U S\u00a0A 114:8065\u20138070","journal-title":"Proc Natl Acad Sci U S A"},{"key":"756_CR32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41419-019-1594-1","volume":"10","author":"M Liang","year":"2019","unstructured":"Liang\u00a0M, Ma\u00a0Q, Ding\u00a0N et al (2019) IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis. Cell Death Dis 10:353","journal-title":"Cell Death Dis"},{"key":"756_CR33","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s13277-014-2844-6","volume":"36","author":"T Liu","year":"2015","unstructured":"Liu\u00a0T, Ma\u00a0Q, Zhang\u00a0Y et al (2015) Interleukin-11 receptor alpha is overexpressed in human osteosarcoma, and near-infrared-labeled IL-11Ralpha imaging agent could detect osteosarcoma in mouse tumor xenografts. Tumour Biol 36:2369\u20132375","journal-title":"Tumour Biol"},{"key":"756_CR34","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.bbamcr.2017.06.008","volume":"1864","author":"J Lokau","year":"2017","unstructured":"Lokau\u00a0J, Agthe\u00a0M, Flynn\u00a0CM et al (2017) Proteolytic control of Interleukin-11 and Interleukin\u20116 biology. Biochim Biophys Acta 1864:2105\u20132117","journal-title":"Biochim Biophys Acta"},{"key":"756_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1785021","author":"J Lokau","year":"2016","unstructured":"Lokau\u00a0J, Agthe\u00a0M, Garbers\u00a0C (2016) Generation of soluble Interleukin-11 and Interleukin\u20116 receptors: a crucial function for proteases during inflammation. Mediators Inflamm. https:\/\/doi.org\/10.1155\/2016\/1785021","journal-title":"Mediators Inflamm"},{"key":"756_CR36","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.1978757","volume":"250","author":"D Malkin","year":"1990","unstructured":"Malkin\u00a0D, Li\u00a0FP, Strong\u00a0LC et\u00a0al (1990) Germ line p53 mutations in a\u00a0familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233\u20131238","journal-title":"Science"},{"key":"756_CR37","first-page":"825","volume":"30","author":"T Nakayama","year":"2007","unstructured":"Nakayama\u00a0T, Yoshizaki\u00a0A, Izumida\u00a0S et al (2007) Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. Int J Oncol 30:825\u2013833","journal-title":"Int J Oncol"},{"key":"756_CR38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cytogfr.2016.06.002","volume":"32","author":"M Negahdaripour","year":"2016","unstructured":"Negahdaripour\u00a0M, Nezafat\u00a0N, Ghasemi\u00a0Y (2016) A panoramic review and in silico analysis of IL-11 structure and function. Cytokine Growth Factor Rev 32:41\u201361","journal-title":"Cytokine Growth Factor Rev"},{"key":"756_CR39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ajhg.2011.05.024","volume":"89","author":"P Nieminen","year":"2011","unstructured":"Nieminen\u00a0P, Morgan\u00a0N, Fenwick\u00a0A et\u00a0al (2011) Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Am J Hum Genet 89:67\u201381","journal-title":"Am J Hum Genet"},{"key":"756_CR40","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.2002056","volume":"5","author":"T Nishina","year":"2012","unstructured":"Nishina\u00a0T, Komazawa-Sakon\u00a0S, Yanaka\u00a0S et al (2012) Interleukin-11 links oxidative stress and compensatory proliferation. Sci Signal 5:ra5","journal-title":"Sci Signal"},{"key":"756_CR41","volume-title":"Knochentumoren mit Kiefertumoren","author":"H Ostertag","year":"2010","unstructured":"Ostertag\u00a0H, Jundt\u00a0G (2010) Knochentumoren mit Kiefertumoren, 3.\u00a0Aufl.","edition":"3"},{"key":"756_CR42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4419-0284-9_1","volume":"152","author":"G Ottaviani","year":"2009","unstructured":"Ottaviani\u00a0G, Jaffe\u00a0N (2009) The epidemiology of osteosarcoma. Cancer Treat Res 152:3\u201313","journal-title":"Cancer Treat Res"},{"key":"756_CR43","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1073\/pnas.87.19.7512","volume":"87","author":"SR Paul","year":"1990","unstructured":"Paul\u00a0SR, Bennett\u00a0F, Calvetti\u00a0JA et al (1990) Molecular cloning of a\u00a0cDNA encoding interleukin 11, a\u00a0stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S\u00a0A 87:7512\u20137516","journal-title":"Proc Natl Acad Sci U S A"},{"key":"756_CR44","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1189\/jlb.0410226","volume":"88","author":"T Putoczki","year":"2010","unstructured":"Putoczki\u00a0T, Ernst\u00a0M (2010) More than a\u00a0sidekick: the IL\u20116 family cytokine IL-11 links inflammation to cancer. J\u00a0Leukoc Biol 88:1109\u20131117","journal-title":"J Leukoc Biol"},{"key":"756_CR45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2013.06.017","volume":"24","author":"T Putoczki","year":"2013","unstructured":"Putoczki\u00a0T, Thiem\u00a0S, Loving\u00a0A et al (2013) Interleukin-11 is the dominant IL\u20116 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 24:257\u2013271","journal-title":"Cancer Cell"},{"key":"756_CR46","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s12032-013-0634-4","volume":"30","author":"L Ren","year":"2013","unstructured":"Ren\u00a0L, Wang\u00a0X, Dong\u00a0Z et al (2013) Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130\/STAT3 pathway. Med Oncol 30:634","journal-title":"Med Oncol"},{"key":"756_CR47","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1084\/jem.183.6.2581","volume":"183","author":"E Romas","year":"1996","unstructured":"Romas\u00a0E, Udagawa\u00a0N, Zhou\u00a0H et al (1996) The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J\u00a0Exp Med 183:2581\u20132591","journal-title":"J Exp Med"},{"key":"756_CR48","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.4049\/jimmunol.148.12.4066","volume":"148","author":"M Saito","year":"1992","unstructured":"Saito\u00a0M, Yoshida\u00a0K, Hibi\u00a0M et al (1992) Molecular cloning of a\u00a0murine IL\u20116 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J\u00a0Immunol 148:4066\u20134071","journal-title":"J Immunol"},{"key":"756_CR49","doi-asserted-by":"crossref","first-page":"548151","DOI":"10.1155\/2011\/548151","volume":"2011","author":"SA Savage","year":"2011","unstructured":"Savage\u00a0SA, Mirabello\u00a0L (2011) Using epidemiology and genomics to understand osteosarcoma etiology. Sarcoma 2011:548151","journal-title":"Sarcoma"},{"key":"756_CR50","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","volume":"552","author":"S Schafer","year":"2017","unstructured":"Schafer\u00a0S, Viswanathan\u00a0S, Widjaja\u00a0AA et\u00a0al (2017) IL11 is a\u00a0crucial determinant of cardiovascular fibrosis. Nature 552:110\u2013115","journal-title":"Nature"},{"key":"756_CR51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ejhg.2008.154","volume":"17","author":"HA Siitonen","year":"2009","unstructured":"Siitonen\u00a0HA, Sotkasiira\u00a0J, Biervliet\u00a0M et\u00a0al (2009) The mutation spectrum in RECQL4 diseases. Eur J Hum Genet 17:151\u2013158","journal-title":"Eur J Hum Genet"},{"key":"756_CR52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biocel.2016.08.003","volume":"79","author":"NA Sims","year":"2016","unstructured":"Sims\u00a0NA (2016) Cell-specific paracrine actions of IL\u20116 family cytokines from bone, marrow and muscle that control bone formation and resorption. Int J Biochem Cell Biol 79:14\u201323","journal-title":"Int J Biochem Cell Biol"},{"key":"756_CR53","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1359\/JBMR.050209","volume":"20","author":"NA Sims","year":"2005","unstructured":"Sims\u00a0NA, Jenkins\u00a0BJ, Nakamura\u00a0A et al (2005) Interleukin-11 receptor signaling is required for normal bone remodeling. J\u00a0Bone Miner Res 20:1093\u20131102","journal-title":"J Bone Miner Res"},{"key":"756_CR54","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1182\/blood.V84.12.4125.bloodjournal84124125","volume":"84","author":"Y Suen","year":"1994","unstructured":"Suen\u00a0Y, Chang\u00a0M, Lee\u00a0SM et al (1994) Regulation of interleukin-11 protein and mRNA expression in neonatal and adult fibroblasts and endothelial cells. Blood 84:4125\u20134134","journal-title":"Blood"},{"key":"756_CR55","doi-asserted-by":"crossref","first-page":"eaal3321","DOI":"10.1126\/science.aal3321","volume":"356","author":"PJ Thul","year":"2017","unstructured":"Thul\u00a0PJ, Akesson\u00a0L, Wiking\u00a0M et\u00a0al (2017) A subcellular map of the human proteome. Science 356:eaal3321","journal-title":"Science"},{"key":"756_CR56","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0009-9120(98)00062-9","volume":"31","author":"P Trontzas","year":"1998","unstructured":"Trontzas\u00a0P, Kamper\u00a0EF, Potamianou\u00a0A et al (1998) Comparative study of serum and synovial fluid interleukin-11 levels in patients with various arthritides. Clin Biochem 31:673\u2013679","journal-title":"Clin Biochem"},{"key":"756_CR57","doi-asserted-by":"crossref","DOI":"10.55418\/188104193X","volume-title":"Tumors of the bones and joints","author":"KK Unni","year":"2005","unstructured":"Unni\u00a0KK, Inwards\u00a0CY, Bridge\u00a0JA et\u00a0al (2005) Tumors of the bones and joints. Armed Forces Institute of Pathology : American Registry of Pathology, Armed Forces Institute of Pathology, Washington, D.C."},{"key":"756_CR58","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/sj.leu.2400846","volume":"11","author":"JC Wang","year":"1997","unstructured":"Wang\u00a0JC, Chen\u00a0C, Lou\u00a0LH et al (1997) Blood thrombopoietin, IL\u20116 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia 11:1827\u20131832","journal-title":"Leukemia"},{"key":"756_CR59","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1158\/1535-7163.MCT-15-0677","volume":"15","author":"AL Winship","year":"2016","unstructured":"Winship\u00a0AL, Van Sinderen\u00a0M, Donoghue\u00a0J et al (2016) Targeting Interleukin-11 Receptor\u2011\u03b1 Impairs Human Endometrial Cancer Cell Proliferation and Invasion in vitro and Reduces Tumour Growth and Metastasis in vivo. Mol Cancer Ther 15:720\u2013730","journal-title":"Mol Cancer Ther"}],"container-title":["Der Pathologe"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-020-00756-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00292-020-00756-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-020-00756-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:54:30Z","timestamp":1695801270000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00292-020-00756-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,20]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["756"],"URL":"https:\/\/doi.org\/10.1007\/s00292-020-00756-1","relation":{},"ISSN":["0172-8113","1432-1963"],"issn-type":[{"value":"0172-8113","type":"print"},{"value":"1432-1963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,20]]},"assertion":[{"value":"20 February 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"C.\u00a0Garbers hat einen \u201eresearch grant\u201c der Firma Corvidia Therapeutics (Waltham, MA, USA) erhalten. J.\u00a0Lokau und V.\u00a0Schoeder und geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}