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Hierzu geh\u00f6ren bei der autoimmunen Hepatitis (AIH) das Bild einer chronischen Hepatitis mit plasmazellreicher dominierender Grenzfl\u00e4chenaktivit\u00e4t, Rosettierung der Hepatozyten und Emperipolese, bei der prim\u00e4ren bili\u00e4ren Cholangitis (PBC) chronische, nichteitrige, destruierende Gallengangsl\u00e4sionen, bei der prim\u00e4ren sklerosierenden Cholangitis (PSC) die zwiebelschalenartige periduktale Fibrose bis zur ver\u00f6denden Gangsklerose. Histopathologische Schnittmengenbefunde dieser Entit\u00e4ten untereinander kennzeichnen Varianten der AIH bzw. Overlapsyndrome. Die Diagnose autoimmuner Lebererkrankungen beruht auf der Gesamtkonstellation klinischer, enzymserologischer, immunserologischer und bildgebender Befunde, zu denen fakultativ oder obligat die Leberbiopsie hinzugezogen wird. Der Leberbiopsie kommt eine gewichtige Rolle zu bei der Diagnose der AIH und ihrer Varianten, der Small-Duct-PSC, der AMA-negativen PBC, der IgG4-assoziierten Entz\u00fcndungen und der Abgrenzung gegen\u00fcber konkurrierenden Lebererkrankungen insbesondere der medikament\u00f6s-toxischen Lebersch\u00e4digung. Damit leistet die histologisch gest\u00fctzte Diagnose einen gewichtigen Beitrag zu einer differenzierten Therapie autoimmun-entz\u00fcndlicher Lebererkrankungen.<\/jats:p>","DOI":"10.1007\/s00292-020-00807-7","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T12:02:36Z","timestamp":1596542556000},"page":"444-456","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autoimmune Lebererkrankungen","Autoimmune liver diseases"],"prefix":"10.1007","volume":"41","author":[{"given":"Hans-Peter","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Goltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"807_CR1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00795-014-0082-z","volume":"47","author":"K Abe","year":"2014","unstructured":"Abe\u00a0K, Takahashi\u00a0A, Nozawa\u00a0Y et\u00a0al (2014) The utility of IgG, IgM, and CD138 immunohistochemistry in the evaluation of autoimmune liver disease. 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